Nature Immunology最新文献_第5页

Innate immune cells link dietary cues to normal and abnormal metabolic regulation 先天免疫细胞将饮食线索与正常和异常的代谢调节联系起来

IF 27.7 1区医学

Nature Immunology Pub Date : 2025-01-02 DOI: 10.1038/s41590-024-02037-y

Peng Zhang, Kosuke Watari, Michael Karin

{"title":"Innate immune cells link dietary cues to normal and abnormal metabolic regulation","authors":"Peng Zhang, Kosuke Watari, Michael Karin","doi":"10.1038/s41590-024-02037-y","DOIUrl":"10.1038/s41590-024-02037-y","url":null,"abstract":"A slew of common metabolic disorders, including type 2 diabetes, metabolic dysfunction-associated steatotic liver disease and steatohepatitis, are exponentially increasing in our sedentary and overfed society. While macronutrients directly impact metabolism and bioenergetics, new evidence implicates immune cells as critical sensors of nutritional cues and important regulators of metabolic homeostasis. A deeper interrogation of the intricate and multipartite interactions between dietary components, immune cells and metabolically active tissues is needed for a better understanding of metabolic regulation and development of new treatments for common metabolic diseases. Responding to macronutrients and micronutrients, immune cells play pivotal roles in interorgan communication between the microbiota, small intestine, metabolically active cells including hepatocytes and adipocytes, and the brain, which controls feeding behavior and energy expenditure. This Review focuses on the response of myeloid cells and innate lymphocytes to dietary cues, their cross-regulatory interactions and roles in normal and aberrant metabolic control. Karin and colleagues review the response of myeloid cells and innate lymphocytes to dietary cues, their cross-regulatory interactions and roles in normal and aberrant metabolic control.","PeriodicalId":19032,"journal":{"name":"Nature Immunology","volume":"26 1","pages":"29-41"},"PeriodicalIF":27.7,"publicationDate":"2025-01-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142913073","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Platelet partnerships and lasting memories 血小板的伙伴关系和持久的记忆

IF 27.7 1区医学

Nature Immunology Pub Date : 2025-01-02 DOI: 10.1038/s41590-024-02040-3

Petter Brodin

引用次数: 0

Latent HIV-1 induction 潜伏HIV-1诱导

IF 27.7 1区医学

Nature Immunology Pub Date : 2025-01-02 DOI: 10.1038/s41590-024-02055-w

Paula Jauregui

引用次数: 0

Antigen experience history directs distinct functional states of CD8+ CAR T cells during the antileukemia response 抗原经历史指导CD8+ CAR - T细胞在抗白血病反应中的不同功能状态

IF 27.7 1区医学

Nature Immunology Pub Date : 2025-01-02 DOI: 10.1038/s41590-024-02034-1

Kole R. DeGolier, Etienne Danis, Marc D’Antonio, Jennifer Cimons, Michael Yarnell, Ross M. Kedl, M. Eric Kohler, James P. Scott-Browne, Terry J. Fry

{"title":"Antigen experience history directs distinct functional states of CD8+ CAR T cells during the antileukemia response","authors":"Kole R. DeGolier, Etienne Danis, Marc D’Antonio, Jennifer Cimons, Michael Yarnell, Ross M. Kedl, M. Eric Kohler, James P. Scott-Browne, Terry J. Fry","doi":"10.1038/s41590-024-02034-1","DOIUrl":"10.1038/s41590-024-02034-1","url":null,"abstract":"Although chimeric antigen receptor (CAR) T cells are effective against B-lineage malignancies, post-CAR relapse is common, and efficacy in other tumors is limited. These challenges may be addressed through rational manipulations to control CAR T cell function. Here we examine the impact of cognate T cell antigen experience on subsequent CD8+ CAR T cell activity. Prior antigen encounter resulted in superior effector function against leukemia expressing low target antigen density at the expense of reduced proliferative capacity and susceptibility to dysfunction at limiting CAR doses. Distinctive temporal transcriptomic and epigenetic profiles in naive-derived and memory-derived CAR T cells identified RUNX family transcription factors as potential targets to augment the function of naive-derived CD8+ CAR T cells. RUNX2 overexpression enhanced antitumor efficacy of mouse CAR T cells, dependent on prior cell state, and heightened human CAR T cell functions. Our data demonstrate that prior antigen experience of CAR T cells determines functional attributes and amenability to transcription factor-mediated functional enhancement. Here, Fry and colleagues examine the impact of antigen experience on subsequent CD8+ CAR T cell activity during the antileukemia response and show that RUNX2 overexpression enhances antitumor activity of these cells.","PeriodicalId":19032,"journal":{"name":"Nature Immunology","volume":"26 1","pages":"68-81"},"PeriodicalIF":27.7,"publicationDate":"2025-01-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.nature.com/articles/s41590-024-02034-1.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142913075","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The Creation Game: of AI and human creativity 创造游戏：人工智能和人类的创造力

IF 27.7 1区医学

Nature Immunology Pub Date : 2025-01-02 DOI: 10.1038/s41590-024-02026-1

Bali Pulendran

引用次数: 0

Past interactions of T cells with antigens shape CAR T cell responses 过去T细胞与抗原的相互作用形成CAR - T细胞反应

IF 27.7 1区医学

Nature Immunology Pub Date : 2025-01-02 DOI: 10.1038/s41590-024-02048-9

引用次数: 0

KEAP1 maintains stemness KEAP1保持干性

IF 27.7 1区医学

Nature Immunology Pub Date : 2025-01-02 DOI: 10.1038/s41590-024-02054-x

Ioana Staicu

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Sex differences in demyelination 脱髓鞘的性别差异

IF 27.7 1区医学

Nature Immunology Pub Date : 2025-01-02 DOI: 10.1038/s41590-024-02057-8

Stephanie Houston

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The heterogeneity of neutrophils in cancer and its implication for therapeutic targeting 肿瘤中性粒细胞的异质性及其对治疗靶向的意义

IF 27.7 1区医学

Nature Immunology Pub Date : 2025-01-02 DOI: 10.1038/s41590-024-02029-y

Evgeniy Eruslanov, Yulia Nefedova, Dmitry I. Gabrilovich

{"title":"The heterogeneity of neutrophils in cancer and its implication for therapeutic targeting","authors":"Evgeniy Eruslanov, Yulia Nefedova, Dmitry I. Gabrilovich","doi":"10.1038/s41590-024-02029-y","DOIUrl":"10.1038/s41590-024-02029-y","url":null,"abstract":"Neutrophils have a pivotal role in safeguarding the host against pathogens and facilitating tissue remodeling. They possess a large array of tools essential for executing these functions. Neutrophils have a critical role in cancer, where they are largely associated with negative clinical outcome and resistance to therapy. However, the specific role of neutrophils in cancer is complex and controversial, owing to their high functional diversity and acute sensitivity to the microenvironment. In this Perspective, we discuss the accumulated evidence that suggests that the functional diversity of neutrophils can be ascribed to two principal functional states, each with distinct characteristics: classically activated neutrophils and pathologically activated immunosuppressive myeloid-derived suppressor cells. We discuss how the antimicrobial factors in neutrophils can contribute to tumor progression and the fundamental mechanisms that govern the pathologically activated myeloid-derived suppressor cells. These functional states play divergent roles in cancer and thus require separate consideration in therapeutic targeting. Gabrilovich and colleagues discuss how the functional diversity of neutrophils in cancer can be ascribed to two functional states: classically activated neutrophils and pathologically activated myeloid-derived suppressor cells.","PeriodicalId":19032,"journal":{"name":"Nature Immunology","volume":"26 1","pages":"17-28"},"PeriodicalIF":27.7,"publicationDate":"2025-01-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142913060","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

IGF2 drives CAF evasion IGF2驱动CAF规避

IF 27.7 1区医学

Nature Immunology Pub Date : 2025-01-02 DOI: 10.1038/s41590-024-02056-9

Laurie A. Dempsey

引用次数: 0