发布求助
文献互助 智能选刊 最新文献

Nature Immunology最新文献

筛选
英文 中文
The epigenetic landscape of fate decisions in T cells T细胞命运决定的表观遗传景观
IF 27.7 1区 医学
Nature Immunology Pub Date : 2025-03-19 DOI: 10.1038/s41590-025-02113-x
Atishay Jay, Carlos M. Pondevida, Golnaz Vahedi
{"title":"The epigenetic landscape of fate decisions in T cells","authors":"Atishay Jay, Carlos M. Pondevida, Golnaz Vahedi","doi":"10.1038/s41590-025-02113-x","DOIUrl":"10.1038/s41590-025-02113-x","url":null,"abstract":"Specialized T cell subsets mediate adaptive immunity in response to cytokine signaling and specific transcription factor activity. The epigenetic landscape of T cells has an important role in facilitating and establishing T cell fate decisions. Here, we review the interplay between transcription factors, histone modifications, DNA methylation and three-dimensional chromatin organization to define key elements of the epigenetic landscape in T cells. We introduce key technologies in the areas of sequencing, microscopy and proteomics that have enabled the multi-scale profiling of the epigenetic landscape. We highlight the dramatic changes of the epigenetic landscape as multipotent progenitor cells commit to the T cell lineage during development and discuss the epigenetic changes that favor the emergence of CD4+ and CD8+ T cells. Finally, we discuss the inheritance of epigenetic marks and its potential effects on immune responses as well as therapeutic strategies with potential for epigenetic regulation. Vahedi and colleagues review the mechanisms shaping the epigenetic landscape of CD4+ and CD8+ T cells during development and differentiation.","PeriodicalId":19032,"journal":{"name":"Nature Immunology","volume":"26 4","pages":"544-556"},"PeriodicalIF":27.7,"publicationDate":"2025-03-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143653840","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Recycling dead bacteria to fuel macrophage immunometabolism 循环利用死细菌为巨噬细胞免疫代谢提供燃料
IF 27.7 1区 医学
Nature Immunology Pub Date : 2025-03-19 DOI: 10.1038/s41590-025-02117-7
Shane M. O’Carroll, Luke A. J. O’Neill
{"title":"Recycling dead bacteria to fuel macrophage immunometabolism","authors":"Shane M. O’Carroll, Luke A. J. O’Neill","doi":"10.1038/s41590-025-02117-7","DOIUrl":"10.1038/s41590-025-02117-7","url":null,"abstract":"Macrophages can recycle nutrients and metabolites from bacteria that they phagocytose. New work is showing how this process can differ between dead and viable bacteria and the effect this distinction has on regulating immune responses and the immunometabolism of the macrophage.","PeriodicalId":19032,"journal":{"name":"Nature Immunology","volume":"26 4","pages":"529-530"},"PeriodicalIF":27.7,"publicationDate":"2025-03-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143653842","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Multiplex targeting of immune-modulating genes in cancer 免疫调节基因在癌症中的多重靶向作用
IF 27.7 1区 医学
Nature Immunology Pub Date : 2025-03-19 DOI: 10.1038/s41590-025-02115-9
Erica L. Braverman, Dario A. A. Vignali, Creg J. Workman
{"title":"Multiplex targeting of immune-modulating genes in cancer","authors":"Erica L. Braverman, Dario A. A. Vignali, Creg J. Workman","doi":"10.1038/s41590-025-02115-9","DOIUrl":"10.1038/s41590-025-02115-9","url":null,"abstract":"A combinatorial therapeutic strategy that modulates several gene targets within the tumor microenvironment through a CRISPR–Cas13d system leads to a significant boost in anti-tumor immunity and ultimately tumor clearance.","PeriodicalId":19032,"journal":{"name":"Nature Immunology","volume":"26 4","pages":"531-533"},"PeriodicalIF":27.7,"publicationDate":"2025-03-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143653843","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The brain’s regulators 大脑的调节器
IF 27.7 1区 医学
Nature Immunology Pub Date : 2025-03-19 DOI: 10.1038/s41590-025-02116-8
Gustavo Gastão Davanzo, Jonathan Kipnis
{"title":"The brain’s regulators","authors":"Gustavo Gastão Davanzo, Jonathan Kipnis","doi":"10.1038/s41590-025-02116-8","DOIUrl":"10.1038/s41590-025-02116-8","url":null,"abstract":"Once seen as a passive barrier, the dura mater is now recognized as an active immune site. A study now suggests that regulatory T cells within the dura mater modulate immune responses by restricting the production of IFNγ and controlling immune cell infiltration in the central nervous system (CNS) parenchyma.","PeriodicalId":19032,"journal":{"name":"Nature Immunology","volume":"26 4","pages":"534-535"},"PeriodicalIF":27.7,"publicationDate":"2025-03-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143653844","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Navigating the path forward for evidence-based management of long COVID 引导循证管理长期COVID的前进道路
IF 27.7 1区 医学
Nature Immunology Pub Date : 2025-03-19 DOI: 10.1038/s41590-025-02118-6
Joseph J. Breen, Robert W. Eisinger, Sarah W. Read, John Beigel, Tara N. Palmore, H. Clifford Lane, Joseph P. Menetski, Stacey J. Adam, Elizabeth Geerling, Emma Roy, Julie Gerberding, Jeanne M. Marrazzo
{"title":"Navigating the path forward for evidence-based management of long COVID","authors":"Joseph J. Breen, Robert W. Eisinger, Sarah W. Read, John Beigel, Tara N. Palmore, H. Clifford Lane, Joseph P. Menetski, Stacey J. Adam, Elizabeth Geerling, Emma Roy, Julie Gerberding, Jeanne M. Marrazzo","doi":"10.1038/s41590-025-02118-6","DOIUrl":"10.1038/s41590-025-02118-6","url":null,"abstract":"The US National Institute of Allergy and Infectious Diseases (NIAID) and the Foundation for the National Institutes of Health (FNIH) held a three-day workshop to assess the landscape of long COVID clinical studies and develop plans for the RECOVER-TLC clinical trials program.","PeriodicalId":19032,"journal":{"name":"Nature Immunology","volume":"26 4","pages":"536-539"},"PeriodicalIF":27.7,"publicationDate":"2025-03-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.nature.com/articles/s41590-025-02118-6.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143653736","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Tuft cell IL-17RB restrains IL-25 bioavailability and reveals context-dependent ILC2 hypoproliferation 簇状细胞IL-17RB抑制IL-25的生物利用度，揭示了环境依赖性ILC2的低增殖
IF 27.7 1区 医学
Nature Immunology Pub Date : 2025-03-12 DOI: 10.1038/s41590-025-02104-y
Xiaogang Feng, Tilde Andersson, Pascal Flüchter, Julia Gschwend, Ivan Berest, Julian L. Muff, Antonie Lechner, Aurelia Gondrand, Patrick Westermann, Nina Brander, Daniele Carchidi, Jeshua C. De Tenorio, Tianlang Pan, Ulrich Boehm, Christoph S. N. Klose, David Artis, Christoph B. Messner, Trese Leinders-Zufall, Frank Zufall, Christoph Schneider
{"title":"Tuft cell IL-17RB restrains IL-25 bioavailability and reveals context-dependent ILC2 hypoproliferation","authors":"Xiaogang Feng, Tilde Andersson, Pascal Flüchter, Julia Gschwend, Ivan Berest, Julian L. Muff, Antonie Lechner, Aurelia Gondrand, Patrick Westermann, Nina Brander, Daniele Carchidi, Jeshua C. De Tenorio, Tianlang Pan, Ulrich Boehm, Christoph S. N. Klose, David Artis, Christoph B. Messner, Trese Leinders-Zufall, Frank Zufall, Christoph Schneider","doi":"10.1038/s41590-025-02104-y","DOIUrl":"10.1038/s41590-025-02104-y","url":null,"abstract":"The tuft cell–group 2 innate lymphoid cell (ILC2) circuit orchestrates rapid type 2 responses upon detecting microbially derived succinate and luminal helminths. Our findings delineate key mechanistic steps involving IP3R2 engagement and Ca2+ flux, governing interleukin-25 (IL-25) production by tuft cells triggered by succinate detection. While IL-17RB has a pivotal intrinsic role in ILC2 activation, it exerts a regulatory function in tuft cells. Tuft cells exhibit constitutive Il25 expression, placing them in an anticipatory state that facilitates rapid production of IL-25 protein for ILC2 activation. Tuft cell IL-17RB is crucial for restraining IL-25 bioavailability, preventing excessive tonic ILC2 stimulation due to basal Il25 expression. Supraoptimal ILC2 stimulation by IL-25 resulting from tuft cell Il17rb deficiency or prolonged succinate exposure induces a state of hypoproliferation in ILC2s, also observed in chronic helminth infection. Our study offers critical insights into the regulatory dynamics of IL-25 in this circuit, highlighting the delicate tuning required for responses to diverse luminal states. Tuft cells constitutively express IL-25 to sustain ILC2 homeostasis in the intestine, but mechanisms driving IL-25 secretion have been unclear. Here, Feng et al. find that tuft cells express IL-17RB, which is required to regulate the bioavailability of IL-25 and to restrain the activation of ILC2s during homeostasis.","PeriodicalId":19032,"journal":{"name":"Nature Immunology","volume":"26 4","pages":"567-581"},"PeriodicalIF":27.7,"publicationDate":"2025-03-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.nature.com/articles/s41590-025-02104-y.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143598835","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Stored mRNA enables rapid cytokine production in tissue-resident memory T cells 储存的mRNA使组织驻留记忆T细胞快速产生细胞因子
IF 27.7 1区 医学
Nature Immunology Pub Date : 2025-03-11 DOI: 10.1038/s41590-025-02111-z
{"title":"Stored mRNA enables rapid cytokine production in tissue-resident memory T cells","authors":"","doi":"10.1038/s41590-025-02111-z","DOIUrl":"10.1038/s41590-025-02111-z","url":null,"abstract":"Using single-cell RNA sequencing and mRNA translation analysis, we identified CD4+ tissue-resident memory T cells as a primary T cell subset that stores cytokine mRNA that can subsequently be translated upon T cell activation to rapidly produce cytokine proteins.","PeriodicalId":19032,"journal":{"name":"Nature Immunology","volume":"26 4","pages":"542-543"},"PeriodicalIF":27.7,"publicationDate":"2025-03-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143589616","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Author Correction: The lactate receptor HCAR1 drives the recruitment of immunosuppressive PMN-MDSCs in colorectal cancer 作者更正：在结直肠癌中，乳酸受体HCAR1驱动免疫抑制PMN-MDSCs的募集
IF 27.7 1区 医学
Nature Immunology Pub Date : 2025-03-10 DOI: 10.1038/s41590-025-02121-x
Jiacheng He, Xiaolei Chai, Qiansen Zhang, Yang Wang, Yijie Wang, Xinyu Yang, Jingbo Wu, Bo Feng, Jing Sun, Weiwei Rui, Shuyin Ze, Yuanyuan Fu, Yumiao Zhao, Ying Zhang, Yao Zhang, Meizhen Liu, Chuang Liu, Meifu She, Xiangfei Hu, Xueyun Ma, Huaiyu Yang, Dawei Li, Senlin Zhao, Guichao Li, Zhen Zhang, Zhonghui Tian, Yanlin Ma, Lingyan Cao, Bo Yi, Dali Li, Ruth Nussinov, Charis Eng, Timothy A. Chan, Eytan Ruppin, J. Silvio Gutkind, Feixiong Cheng, Mingyao Liu, Weiqiang Lu
{"title":"Author Correction: The lactate receptor HCAR1 drives the recruitment of immunosuppressive PMN-MDSCs in colorectal cancer","authors":"Jiacheng He, Xiaolei Chai, Qiansen Zhang, Yang Wang, Yijie Wang, Xinyu Yang, Jingbo Wu, Bo Feng, Jing Sun, Weiwei Rui, Shuyin Ze, Yuanyuan Fu, Yumiao Zhao, Ying Zhang, Yao Zhang, Meizhen Liu, Chuang Liu, Meifu She, Xiangfei Hu, Xueyun Ma, Huaiyu Yang, Dawei Li, Senlin Zhao, Guichao Li, Zhen Zhang, Zhonghui Tian, Yanlin Ma, Lingyan Cao, Bo Yi, Dali Li, Ruth Nussinov, Charis Eng, Timothy A. Chan, Eytan Ruppin, J. Silvio Gutkind, Feixiong Cheng, Mingyao Liu, Weiqiang Lu","doi":"10.1038/s41590-025-02121-x","DOIUrl":"10.1038/s41590-025-02121-x","url":null,"abstract":"","PeriodicalId":19032,"journal":{"name":"Nature Immunology","volume":"26 4","pages":"635-635"},"PeriodicalIF":27.7,"publicationDate":"2025-03-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.nature.com/articles/s41590-025-02121-x.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143582972","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Eva Klein (1925–2025) 伊娃·克莱因（1925-2025）
IF 27.7 1区 医学
Nature Immunology Pub Date : 2025-03-07 DOI: 10.1038/s41590-025-02114-w
Maria G. Masucci, Ingemar Ernberg
{"title":"Eva Klein (1925–2025)","authors":"Maria G. Masucci, Ingemar Ernberg","doi":"10.1038/s41590-025-02114-w","DOIUrl":"10.1038/s41590-025-02114-w","url":null,"abstract":"","PeriodicalId":19032,"journal":{"name":"Nature Immunology","volume":"26 4","pages":"527-527"},"PeriodicalIF":27.7,"publicationDate":"2025-03-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143569640","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The integrated stress response pathway controls cytokine production in tissue-resident memory CD4+ T cells 综合应激反应途径控制组织驻留记忆CD4+ T细胞中细胞因子的产生
IF 27.7 1区 医学
Nature Immunology Pub Date : 2025-03-06 DOI: 10.1038/s41590-025-02105-x
Nariaki Asada, Pauline Ginsberg, Hans-Joachim Paust, Ning Song, Jan-Hendrik Riedel, Jan-Eric Turner, Anett Peters, Anna Kaffke, Jonas Engesser, Huiying Wang, Yu Zhao, Robin Khatri, Philipp Gild, Roland Dahlem, Björn-Philipp Diercks, Sarada Das, Zoya Ignatova, Tobias B. Huber, Immo Prinz, Nicola Gagliani, Hans-Willi Mittrücker, Christian F. Krebs, Ulf Panzer
{"title":"The integrated stress response pathway controls cytokine production in tissue-resident memory CD4+ T cells","authors":"Nariaki Asada, Pauline Ginsberg, Hans-Joachim Paust, Ning Song, Jan-Hendrik Riedel, Jan-Eric Turner, Anett Peters, Anna Kaffke, Jonas Engesser, Huiying Wang, Yu Zhao, Robin Khatri, Philipp Gild, Roland Dahlem, Björn-Philipp Diercks, Sarada Das, Zoya Ignatova, Tobias B. Huber, Immo Prinz, Nicola Gagliani, Hans-Willi Mittrücker, Christian F. Krebs, Ulf Panzer","doi":"10.1038/s41590-025-02105-x","DOIUrl":"10.1038/s41590-025-02105-x","url":null,"abstract":"Tissue-resident memory T (TRM) cells are a specialized T cell population that reside in tissues and provide a rapid protective response upon activation. Here, we showed that human and mouse CD4+ TRM cells existed in a poised state and stored messenger RNAs encoding proinflammatory cytokines without protein production. At steady state, cytokine mRNA translation in TRM cells was suppressed by the integrated stress response (ISR) pathway. Upon activation, the central ISR regulator, eIF2α, was dephosphorylated and stored cytokine mRNA was translated for immediate cytokine production. Genetic or pharmacological activation of the ISR–eIF2α pathway reduced cytokine production and ameliorated autoimmune kidney disease in mice. Consistent with these results, the ISR pathway in CD4+ TRM cells was downregulated in patients with immune-mediated diseases of the kidney and the intestine compared to healthy controls. Our results indicated that stored cytokine mRNA and translational regulation in CD4+ TRM cells facilitate rapid cytokine production during local immune response. Panzer and colleagues show that the integrated stress response pathway regulates cytokine translation in CD4+ TRM cells during homeostasis and inflammation.","PeriodicalId":19032,"journal":{"name":"Nature Immunology","volume":"26 4","pages":"557-566"},"PeriodicalIF":27.7,"publicationDate":"2025-03-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.nature.com/articles/s41590-025-02105-x.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143560764","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
首页 上一页 下一页 尾页
0
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
提示
您的信息不完整，为了账户安全，请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
现在去查看 取消
×
提示
确定
请完成安全验证×
相关产品
×
本文献相关产品
联系我们：info@booksci.cn Book学术提供免费学术资源搜索服务，方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。 Copyright © 2023 布克学术 All rights reserved.
京ICP备2023020795号-1
ghs 京公网安备 11010802042870号
Book学术文献互助
Book学术文献互助群
群 号：481959085
Book学术官方微信