Bacterial toxins rewire the trans-Golgi network to activate the inflammatory response

IF 27.6 1区 医学 Q1 IMMUNOLOGY
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引用次数: 0

Abstract

Cholesterol-dependent cytolysins produced by diverse bacterial pathogens are internalized by host cells and translocate to the trans-Golgi network (TGN). They remodel the TGN into a platform for assembly of the NLRP3 inflammasome, a crucial innate immune signaling pathway in host defense and pro-inflammatory diseases.

Abstract Image

Abstract Image

细菌毒素重新连接反式高尔基网络以激活炎症反应
多种细菌病原体产生的胆固醇依赖性细胞溶解素被宿主细胞内化并转运到反式高尔基网络(TGN)。他们将TGN重塑为NLRP3炎性小体的组装平台,NLRP3炎性小体是宿主防御和促炎疾病中至关重要的先天免疫信号通路。
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来源期刊
Nature Immunology
Nature Immunology 医学-免疫学
CiteScore
40.00
自引率
2.30%
发文量
248
审稿时长
4-8 weeks
期刊介绍: Nature Immunology is a monthly journal that publishes the highest quality research in all areas of immunology. The editorial decisions are made by a team of full-time professional editors. The journal prioritizes work that provides translational and/or fundamental insight into the workings of the immune system. It covers a wide range of topics including innate immunity and inflammation, development, immune receptors, signaling and apoptosis, antigen presentation, gene regulation and recombination, cellular and systemic immunity, vaccines, immune tolerance, autoimmunity, tumor immunology, and microbial immunopathology. In addition to publishing significant original research, Nature Immunology also includes comments, News and Views, research highlights, matters arising from readers, and reviews of the literature. The journal serves as a major conduit of top-quality information for the immunology community.
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