Molecular Plant最新文献_第4页

From DNA to RNA to protein: pQTL mapping and Proteome-Wide Association Study reveal protein-level drivers of soybean traits 从DNA到RNA再到蛋白质：pQTL定位和蛋白质组关联研究揭示了大豆性状的蛋白质水平驱动因素

IF 27.5 1区生物学

Molecular Plant Pub Date : 2026-09-22 DOI: 10.1016/j.molp.2026.09.011

Delin Li,Zhan Li,Shiyu Guo,Qi Wang,Xinkang Feng,Hao Zhang,James C. Schnable,Ying-Hui Li,Li-Juan Qiu

引用次数: 0

Nanocarrier-mediated transient reprogramming as a promising strategy for enhancing crop stress resilience 纳米载体介导的瞬时重编程是提高作物抗逆性的一种有前景的策略

IF 27.5 1区生物学

Molecular Plant Pub Date : 2026-09-22 DOI: 10.1016/j.molp.2026.09.008

Wangshan Lu,Yule Ye,Chao Wang,Gan Ai,Daolong Dou

引用次数: 0

OASIS, a self-evolving AI scientist that integrates omics data and literature knowledge for plant stress research OASIS是一个自我进化的人工智能科学家，将组学数据和文献知识整合到植物胁迫研究中

IF 27.5 1区生物学

Molecular Plant Pub Date : 2026-09-18 DOI: 10.1016/j.molp.2026.09.005

Yang Han,Hua Wei,Xianmeng Wang,Yilin Li,Zhipeng Zhang,Bingzhu Liu,Shuwen Wen,Nan Pan,Huiying He,Qian Qian,Lianguang Shang

{"title":"OASIS, a self-evolving AI scientist that integrates omics data and literature knowledge for plant stress research","authors":"Yang Han,Hua Wei,Xianmeng Wang,Yilin Li,Zhipeng Zhang,Bingzhu Liu,Shuwen Wen,Nan Pan,Huiying He,Qian Qian,Lianguang Shang","doi":"10.1016/j.molp.2026.09.005","DOIUrl":"https://doi.org/10.1016/j.molp.2026.09.005","url":null,"abstract":"Abiotic stresses constrain plant growth and crop productivity, yet converting rapidly expanding literature and heterogeneous biological data into testable hypotheses remains difficult. Here we present OASIS, a self-evolving omics-guided AI scientist that links literature-derived mechanistic evidence with omics and other structured data in a traceable workflow for plant stress research. OASIS coordinates six specialized agents for planning, hybrid retrieval, evidence distillation, data interrogation, review, and synthesis. Its knowledge base spans six plant species and four major stress categories and automatically incorporates newly published studies, while the Self-Evolving Experience Learning (SEEL) module distills historical trajectories into reusable procedural rules for experience-based self-evolution. On PlantStressQA, a 200-question expert-curated benchmark, OASIS achieved 84.0/100, exceeding baseline LLMs by 33.9-50.2 points, and showed its largest gains on tasks requiring multi-step integration of literature and data-level evidence. In a rice salt-tolerance case study, OASIS combined Arabidopsis regulatory evidence, orthology, and genetic loci to prioritize five candidates. Loss of OsPP2a function produced salt-response phenotypes accompanied by altered Na+/K+ homeostasis. OASIS is publicly accessible at https://www.oasis.ac.cn.","PeriodicalId":19012,"journal":{"name":"Molecular Plant","volume":"22 1","pages":""},"PeriodicalIF":27.5,"publicationDate":"2026-09-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148993804","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A cis-regulatory allele of ZmNPR1I spatially uncouples flowering from stalk-rot resistance in maize ZmNPR1I的顺式调控等位基因在空间上解除玉米茎秆腐病抗性开花

IF 27.5 1区生物学

Molecular Plant Pub Date : 2026-09-15 DOI: 10.1016/j.molp.2026.09.006

Feili Du,Chenyu Guo,Chenwu Xu,Saihua Chen,Mingliang Xu

{"title":"A cis-regulatory allele of ZmNPR1I spatially uncouples flowering from stalk-rot resistance in maize","authors":"Feili Du,Chenyu Guo,Chenwu Xu,Saihua Chen,Mingliang Xu","doi":"10.1016/j.molp.2026.09.006","DOIUrl":"https://doi.org/10.1016/j.molp.2026.09.006","url":null,"abstract":"Pleiotropic effects of adaptive genes frequently constrain crop improvement by coupling beneficial traits with unfavorable trade-offs. In maize, ZmCCT10 confers strong stalk-rot resistance but causes delayed flowering under long-day conditions, limiting its deployment in temperate breeding. Here, we identify qPss3 as a cis-regulatory locus that governs its downstream target gene, ZmNPR1I. The ZmNPR1I protein represses ZmCCT10 transcription and, together with ZmNPR1-3, facilitates ZmCCT10 protein degradation. The favorable qPss3A5 allele reduces ZmNPR1I expression in leaves, relieving repression of ZmCCT10, ZmSPL32, and ID1, which collectively enhance ZCN8 expression to accelerate flowering. In roots, however, pathogen-induced activation of the resistant ZmCCT10H5 allele largely bypasses qPss3 regulation, thereby preserving stalk-rot resistance. Introgression of qPss3A5 into ZmCCT10H5-containing maize germplasm restores flowering adaptation without compromising disease resistance, improving yield stability under disease pressure. Our work reveals a tissue-specific qPss3A5-ZmNPR1I regulatory module that uncouples the developmental and immune functions of a pleiotropic adaptive gene, providing a general strategy for optimizing beneficial alleles in crop breeding.","PeriodicalId":19012,"journal":{"name":"Molecular Plant","volume":"28 1","pages":""},"PeriodicalIF":27.5,"publicationDate":"2026-09-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148964342","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

HAIant (智然体): A human-centered AI framework for secure, personalized intelligence augmentation in biological research 海蚁（HAIant）：一个以人为中心的AI框架，用于生物研究中安全、个性化的智能增强

IF 27.5 1区生物学

Molecular Plant Pub Date : 2026-09-09 DOI: 10.1016/j.molp.2026.08.011

Yunlong Zhang,Yunming Wang,Zhilong Zheng,Hao Wu,Xiangfeng Zeng,Qishuai Huang,Wendi Wei,Youkun Fan,Jiachen Du,Jinpeng Liu,Tao Zhou,Guanzhen Zhu,Rui Han,Ruozhuo Zheng,Hongwei Zhang,Chuang Zhang,Yi Wang,Xiangguo Liu,Weifu Li,Zaiwen Feng,Lin Li

{"title":"HAIant (智然体): A human-centered AI framework for secure, personalized intelligence augmentation in biological research","authors":"Yunlong Zhang,Yunming Wang,Zhilong Zheng,Hao Wu,Xiangfeng Zeng,Qishuai Huang,Wendi Wei,Youkun Fan,Jiachen Du,Jinpeng Liu,Tao Zhou,Guanzhen Zhu,Rui Han,Ruozhuo Zheng,Hongwei Zhang,Chuang Zhang,Yi Wang,Xiangguo Liu,Weifu Li,Zaiwen Feng,Lin Li","doi":"10.1016/j.molp.2026.08.011","DOIUrl":"https://doi.org/10.1016/j.molp.2026.08.011","url":null,"abstract":"Artificial intelligence (AI) has achieved human-level capabilities across multiple domains; however, concerns regarding data security, privacy, and domain-specific capability enhancement remain. Here, we present human + AI + ant (HAIant), a human-centered framework for secure and personalized intelligence augmentation based on locally deployed AI. HAIant integrates locally deployed large language models with personal data, individual reasoning processes, and domain-specific tools, enabling user-controlled AI systems while preserving data privacy. Within this framework, HAIant establishes a unified AI-assisted biological research workflow through personal biological knowledge base construction, multi-user communication, and bioinformatics tool invocation. To support domain-specific applications, a bioinformatics skill-execution module named BioSkills, consisting of 84 analytical tools and two domain knowledge bases, is integrated into HAIant. As a proof of concept, we show that the Biological HAIant can support experimental record management, bioinformatics analysis, and automated manuscript generation from experimental data. Collectively, out work demonstrates that HAIant and BioSkills provide a scalable architecture for secure, human-oriented AI systems that advance intelligent scientific workflows.","PeriodicalId":19012,"journal":{"name":"Molecular Plant","volume":"10 1","pages":""},"PeriodicalIF":27.5,"publicationDate":"2026-09-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148908747","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Sucrose-associated SnRK1a1-mediated phosphorylation of Opaque2 modulates endosperm filling in maize 蔗糖相关snrk1a1介导的不透明蛋白2磷酸化调节玉米胚乳填充

IF 27.5 1区生物学

Molecular Plant Pub Date : 2026-09-08 DOI: 10.1016/j.molp.2026.08.022

Tao Yang,Yunqin Huang,Longyu Liao,Shanshan Wang,Haoyu Zhang,Jingying Pan,Yongcai Huang,Xiaoling Li,Di Chen,Tao Liu,Xiaoduo Lu,Yongrui Wu

引用次数: 0

The TANG cluster comprising ten nitrate transporter genes controls fruit sweetness and size in tomato 由十个硝酸盐转运基因组成的TANG基因簇控制着番茄果实的甜度和大小

IF 27.5 1区生物学

Molecular Plant Pub Date : 2026-09-08 DOI: 10.1016/j.molp.2026.09.004

Fangman Li,Xingyu Zhang,Haobo Xu,Xietian Song,Pingfei Ge,Junshen Lin,Pengyu Zhu,Yang Yang,Ziyuan Wang,Genzhong Liu,Sanwen Huang,Zhibiao Ye,Yuyang Zhang

{"title":"The TANG cluster comprising ten nitrate transporter genes controls fruit sweetness and size in tomato","authors":"Fangman Li,Xingyu Zhang,Haobo Xu,Xietian Song,Pingfei Ge,Junshen Lin,Pengyu Zhu,Yang Yang,Ziyuan Wang,Genzhong Liu,Sanwen Huang,Zhibiao Ye,Yuyang Zhang","doi":"10.1016/j.molp.2026.09.004","DOIUrl":"https://doi.org/10.1016/j.molp.2026.09.004","url":null,"abstract":"Sucrose is a major transport form of photoassimilated carbon in tomato, Arabidopsis, and many other plant species, and plays a critical regulatory role in plant growth, development, and fruit quality. Plant vacuoles function as storage organelles, accumulating substantial quantities of metabolically inactive nitrates as a nitrogen reserve and soluble sugars as a carbon reserve. Consequently, the balance between nitrate and sucrose accumulation determines plant growth dynamics and fruit taste. In this study, we identified a gene cluster designated TANG (Total soluble solidsAccumulation viaNitrate transporterGene cluster), comprising ten nitrate transporter genes that are significantly associated with sucrose accumulation in tomato. This gene cluster mediates the transport of nitrate between the cytoplasm and vacuole, thereby influencing its storage. Functional disruption of TANG8, a member of the gene cluster, results in either enhanced sugar accumulation or increased fruit size. Selective disruption of multiple TANG cluster members yields fruits with elevated sweetness and increased fruit size in S. pimpinellifolium. The interaction between the TANG members and a tonoplast localized Sucrose Transporter 4 provides insight into the competitive accumulation of nitrate and sugar. The multiplex editing of a gene cluster provides a successful example of engineering crops with high quality and yield.","PeriodicalId":19012,"journal":{"name":"Molecular Plant","volume":"142 1","pages":""},"PeriodicalIF":27.5,"publicationDate":"2026-09-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148902439","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Molecular mimicry enables engineering of NLR immune receptors with multi-recognition. 分子模拟使NLR免疫受体的多识别工程成为可能。

IF 32.7 1区生物学

Molecular Plant Pub Date : 2026-09-07 Epub Date: 2026-07-13 DOI: 10.1016/j.molp.2026.07.008

Mengyu Qu, Ya Li, Fujia Yang, Guo-Liang Wang, Songbiao Chen

引用次数: 0

Dynamic shading of chloroplasts for enhanced photosynthetic efficiency. 叶绿体动态遮光以提高光合效率。

IF 32.7 1区生物学

Molecular Plant Pub Date : 2026-09-07 Epub Date: 2026-07-18 DOI: 10.1016/j.molp.2026.07.011

Xin-Guang Zhu, Elizabeth A Ainsworth

引用次数: 0

Dual repression of OsSnRK1β1A by the deubiquitinase OsOTUB1 orchestrates energy metabolism and grain yield in rice. 去泛素酶OsOTUB1对OsSnRK1β1A的双重抑制调控了水稻的能量代谢和产量。

IF 32.7 1区生物学

Molecular Plant Pub Date : 2026-09-07 Epub Date: 2026-06-23 DOI: 10.1016/j.molp.2026.06.007

Ludan Zhang, Pengfei Wang, Yue Li, Shuang Yang, Yan Chen, Zhiying Ma, Jing Pan, Xiaoyu Wang, Chenyan Wang, Haoyuan An, Yuqing Xu, Yifei Xiao, Shen Shen, Kun Wu, Zhaosheng Kong, Xiangdong Fu, Shuansuo Wang

{"title":"Dual repression of OsSnRK1β1A by the deubiquitinase OsOTUB1 orchestrates energy metabolism and grain yield in rice.","authors":"Ludan Zhang, Pengfei Wang, Yue Li, Shuang Yang, Yan Chen, Zhiying Ma, Jing Pan, Xiaoyu Wang, Chenyan Wang, Haoyuan An, Yuqing Xu, Yifei Xiao, Shen Shen, Kun Wu, Zhaosheng Kong, Xiangdong Fu, Shuansuo Wang","doi":"10.1016/j.molp.2026.06.007","DOIUrl":"10.1016/j.molp.2026.06.007","url":null,"abstract":"<p><p>Rice grain yield is largely determined by grain number per panicle; however, the molecular basis of this key trait remains largely unclear, particularly regarding how energy metabolism is coordinated with panicle development. To elucidate this, we performed ethylmethanesulfonate (EMS) mutagenesis in the OsOTUB1 loss-of-function mutant npt1 and isolated npt-s1, a suppressor reverting the high-grain-number phenotype of npt1. Map-based cloning identified that NPT-S1 encodes OsSnRK1β1A, a regulatory subunit of the sucrose non-fermenting 1-related protein kinase 1 (SnRK1) energy-sensing complex. Functional analyses showed that OsSnRK1β1A promotes grain number by suppressing energy catabolism. Mechanistically, OsSnRK1β1A binds OsSnRK1α1 and, through N-terminal myristoylation, restricts its nuclear localization, thereby linking energy status to developmental outputs. Furthermore, we discovered that OsOTUB1 directly interacts with OsSnRK1β1A, exerting both competitive inhibition and K63-linked deubiquitination, the latter of which triggers 26S proteasome-mediated degradation. Genetic and transcriptomic analyses suggested that this module determines grain number by reshaping global carbon, nitrogen, and lipid metabolism to prioritize reproductive allocation. Crucially, we demonstrated that engineered upregulation of OsSnRK1β1A via CRISPR/Cas9-mediated promoter editing of CAREOSREP1 and CCAAT box consistently increases grain yield without compromising plant architecture. Together, our findings reveal a layered signaling pathway refined by post-translational modification, in which the OsOTUB1-OsSnRK1β1A module couples energy status to panicle development, providing both a mechanistic framework and actionable targets for breeding high-yield rice.</p>","PeriodicalId":19012,"journal":{"name":"Molecular Plant","volume":" ","pages":"1819-1836"},"PeriodicalIF":32.7,"publicationDate":"2026-09-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148308884","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0