Molecular Plant最新文献

Decoding gibberellin-strigolactone interaction networks in cereal crops toward a next-generation Green Revolution. 解码谷物作物中赤霉素-独角麦内酯相互作用网络，迈向下一代绿色革命。

IF 24.1 1区生物学

Molecular Plant Pub Date : 2026-05-04 Epub Date: 2026-03-10 DOI: 10.1016/j.molp.2026.03.006

Jie Hu, Yunzhe Wu, Shuang Zhang, Qiaoling Zhang, Zhe Chai, Dan Li, Danlin Zhao, Binghui Wu, Xiuhua Gao, Xueying Liu, Kun Wu, Xiangdong Fu

{"title":"Decoding gibberellin-strigolactone interaction networks in cereal crops toward a next-generation Green Revolution.","authors":"Jie Hu, Yunzhe Wu, Shuang Zhang, Qiaoling Zhang, Zhe Chai, Dan Li, Danlin Zhao, Binghui Wu, Xiuhua Gao, Xueying Liu, Kun Wu, Xiangdong Fu","doi":"10.1016/j.molp.2026.03.006","DOIUrl":"10.1016/j.molp.2026.03.006","url":null,"abstract":"The agricultural Green Revolution (GR) of the 1950s and 1960s drove unprecedented increases in crop yields through widespread adoption of semi-dwarf cereal varieties with mutations affecting gibberellin (GA) biosynthesis or signaling pathways. Although semi-dwarf plants exhibited strong lodging resistance, their low nitrogen-use efficiency (NUE) demanded excessive inorganic fertilizer inputs, leading to severe and widespread environmental degradation. To boost sustainable agriculture, the \"next-generation GR (NGR)\" approach has emerged as a promising solution to limit chemical fertilizer use in high-yield crops. Nevertheless, inherent trade-offs between grain yield and NUE remain a major challenge to achieving agricultural sustainability. Strigolactones (SLs), a class of phytohormone discovered in 2008, play multifaceted roles comparable to those of GAs and have demonstrated significant promise for both conventional and modern crop improvement. Recent advances in artificial intelligence (AI)-driven protein engineering suggest that precision pyramiding of favorable alleles from GA and SL biosynthesis and signaling pathways holds a strong potential to revolutionize NGR through optimized phytohormone regulation. This review analyzes the fundamental drivers of GR success, synthesizes current understanding of GA-SL crosstalk in modulating nitrogen-responsive control of plant architecture and branching patterns, and elucidates the coordination between plant growth and metabolism in regulating NUE and grain yield. This knowledge will establish a framework for leveraging beneficial traits while mitigating pleiotropic trade-offs in current cultivars, thereby enabling rapid progress in the NGR breeding programs.","PeriodicalId":19012,"journal":{"name":"Molecular Plant","volume":" ","pages":"949-963"},"PeriodicalIF":24.1,"publicationDate":"2026-05-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147434380","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Histone deacetylases and cell-cycle regulators orchestrate cell-identity transitions during Arabidopsis root regeneration. 组蛋白去乙酰化酶和细胞周期调节剂协调拟南芥根再生过程中细胞身份的转变。

IF 24.1 1区生物学

Molecular Plant Pub Date : 2026-05-04 Epub Date: 2026-03-25 DOI: 10.1016/j.molp.2026.03.013

Ramin Rahni, Laura R Lee, Graeme Vissers, Indie Suresh, Brandon M Gorodokin, Pui-Leng Ip, Bruno Guillotin, Kenneth D Birnbaum

{"title":"Histone deacetylases and cell-cycle regulators orchestrate cell-identity transitions during Arabidopsis root regeneration.","authors":"Ramin Rahni, Laura R Lee, Graeme Vissers, Indie Suresh, Brandon M Gorodokin, Pui-Leng Ip, Bruno Guillotin, Kenneth D Birnbaum","doi":"10.1016/j.molp.2026.03.013","DOIUrl":"10.1016/j.molp.2026.03.013","url":null,"abstract":"The widespread regenerative capacity of plants is mediated by the ability of specialized cells to reprogram their fate, but the sequential cellular states of regenerating plant cells remain an open question. Here, we characterize the trajectory of cellular reprogramming during Arabidopsis root regeneration using single-cell RNA sequencing, ATAC sequencing, imaging, and mutant analysis. The earliest events during regeneration are dependent on repressive chromatin modification, where Multiome and genetic analysis showed that class I histone deacetylases (HDACs) HDA9 and HDA19 play a role in shutting down old identities and to prevent a runaway stress response. Cell division mediates a second step needed for the acquisition of many new identity markers, where division rates were tuned by the DOF transcription factor OBP1 that accelerates and SMR5, SMR7, and SMR10 that decelerate division rates hours later. Collectively, our study provides mechanistic insights into how plants actively mediate the loss of remnant identities within hours of injury and then tune cell-division rates to rapidly reprogram cells to new identities.","PeriodicalId":19012,"journal":{"name":"Molecular Plant","volume":" ","pages":"1036-1058"},"PeriodicalIF":24.1,"publicationDate":"2026-05-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147521361","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Single-nucleotide editing of a strigolactone receptor confers virus resistance in rice. 单核苷酸编辑的独角曲内酯受体赋予水稻病毒抗性。

IF 24.1 1区生物学

Molecular Plant Pub Date : 2026-05-04 Epub Date: 2026-03-06 DOI: 10.1016/j.molp.2026.03.001

Qinglin Pi, Yule Liu

引用次数: 0

WIND1 controls cell fate transition through coordinately integrating histone acetylation and deacetylation-mediated transcriptional reprogramming during somatic embryogenesis. 在体细胞胚胎发生过程中，WIND1通过协调整合组蛋白乙酰化和去乙酰化介导的转录重编程来控制细胞命运的转变。

IF 24.1 1区生物学

Molecular Plant Pub Date : 2026-05-04 Epub Date: 2026-03-10 DOI: 10.1016/j.molp.2026.03.005

Akira Iwase, Arika Takebayashi, Fu-Yu Hung, Ayako Kawamura, Yetkin Çaka Ince, Yasuhiro Kadota, Soichi Inagaki, Takamasa Suzuki, Ken Shirasu, Keiko Sugimoto

{"title":"WIND1 controls cell fate transition through coordinately integrating histone acetylation and deacetylation-mediated transcriptional reprogramming during somatic embryogenesis.","authors":"Akira Iwase, Arika Takebayashi, Fu-Yu Hung, Ayako Kawamura, Yetkin Çaka Ince, Yasuhiro Kadota, Soichi Inagaki, Takamasa Suzuki, Ken Shirasu, Keiko Sugimoto","doi":"10.1016/j.molp.2026.03.005","DOIUrl":"10.1016/j.molp.2026.03.005","url":null,"abstract":"Regeneration involves large-scale transcriptional reprogramming to drive cell identity transitions. These transcriptional changes are tightly coupled with chromatin remodeling, but the molecular mechanisms that coordinate these changes remain unclear. Here, we show that WOUND INDUCED DEDIFFERENTIATION 1 (WIND1) transcription factor promotes somatic embryogenesis by repressing pre-existing cell fate and activating new cell identity programs. WIND1 interacts with histone deacetylase HISTONE DEACETYLASE 9 and histone acetyltransferase complex component HOMOLOG OF YEAST ADA1 2a via a conserved N-terminal domain. These interactions enable WIND1 to mediate both H3K27 deacetylation and acetylation at distinct target loci, leading to repression of organ-primordium/procambium development genes such as AINTEGUMENTA and activation of embryogenesis regulators, including LEAFY COTYLEDON 2. Our study identifies WIND1 as a bifunctional chromatin regulator that integrates opposing histone acetylation dynamics to coordinate transcriptional reprogramming, providing a molecular framework for how a transcription factor directs complex cell fate transitions during regeneration.","PeriodicalId":19012,"journal":{"name":"Molecular Plant","volume":" ","pages":"1019-1035"},"PeriodicalIF":24.1,"publicationDate":"2026-05-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147434337","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

PlantScience.ai: An LLM-powered virtual scientist for plant science. PlantScience。ai：一个基于llm的植物科学虚拟科学家。

IF 24.1 1区生物学

Molecular Plant Pub Date : 2026-05-04 Epub Date: 2026-03-20 DOI: 10.1016/j.molp.2026.03.010

Haopeng Yu, Shasha Zhou, Mingyu Huang, Ling Ding, Yuxuan Chen, Yinru Wang, Yingyu Ren, Nuo Cheng, Xinya Wang, Jie Liang, Huakun Zhang, Yiliang Ding, Ke Li

{"title":"PlantScience.ai: An LLM-powered virtual scientist for plant science.","authors":"Haopeng Yu, Shasha Zhou, Mingyu Huang, Ling Ding, Yuxuan Chen, Yinru Wang, Yingyu Ren, Nuo Cheng, Xinya Wang, Jie Liang, Huakun Zhang, Yiliang Ding, Ke Li","doi":"10.1016/j.molp.2026.03.010","DOIUrl":"10.1016/j.molp.2026.03.010","url":null,"abstract":"The accelerating growth of plant science knowledge presents a major challenge to extracting accurate, up-to-date knowledge from an increasingly fragmented and domain-specific corpus. General-purpose large language models, while powerful, often misinterpret plant science terminology and lack mechanisms for source traceability. We created PlantScience.ai, a virtual plant biology scientist powered by an automated scientific knowledge graph construction pipeline. PlantScience.ai exhibits expert-level reasoning in plant biology and maintains scholarly rigor inciting the literature. Through continuous learning, it integrates the latest research to ensure that its knowledge base remains current and scientifically robust. Apart from providing the answers to scientific questions, PlantScience.ai can interact with human scientists, follow instructions, and retrieve information with citation awareness, grounding each response in primary sources to ensure accuracy and verifiability. PlantScience.ai marks a pivotal advance toward a collaborative scientific paradigm in which virtual and human plant scientists work synergistically to accelerate discovery while preserving the unique value of human insight. PlantScience.ai is available at https://plantscience.ai.","PeriodicalId":19012,"journal":{"name":"Molecular Plant","volume":" ","pages":"1117-1123"},"PeriodicalIF":24.1,"publicationDate":"2026-05-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147494150","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Dephosphorylation and polyubiquitination of the histone variant H2AX act coordinately to terminate DNA damage signaling in Arabidopsis. 组蛋白变体H2AX的去磷酸化和多泛素化协同终止拟南芥DNA损伤信号。

IF 24.1 1区生物学

Molecular Plant Pub Date : 2026-05-04 Epub Date: 2025-12-29 DOI: 10.1016/j.molp.2025.12.029

Xuerui Lu, Xiaodan Yu, Zhiping Deng, Zhichao Wang, Lvwen Zhang, Shixi Shi, Lili Wang, Shunping Yan

{"title":"Dephosphorylation and polyubiquitination of the histone variant H2AX act coordinately to terminate DNA damage signaling in Arabidopsis.","authors":"Xuerui Lu, Xiaodan Yu, Zhiping Deng, Zhichao Wang, Lvwen Zhang, Shixi Shi, Lili Wang, Shunping Yan","doi":"10.1016/j.molp.2025.12.029","DOIUrl":"10.1016/j.molp.2025.12.029","url":null,"abstract":"Both activation and termination of the DNA damage response (DDR) are essential for maintaining genome stability. It is well established that the histone variant H2AX is rapidly phosphorylated to initiate the DDR in eukaryotes; however, how H2AX signaling is terminated remains poorly understood, particularly in plants. Through forward genetic screening in Arabidopsis, we identify the DNA damage response mutant 5 (ddrm5), which is hypersensitive to DNA damage-inducing agents. Gene mapping and genetic complementation analyses reveal that DDRM5 encodes the plant-specific phosphatase MAIL3, whose phosphatase domain is both necessary and sufficient for its function in the DDR. Biochemically, MAIL3 physically interacts with and dephosphorylates H2AX, thereby promoting its polyubiquitination at Lys103 and Lys127 by the E3 ubiquitin ligase SCFAFB1 and leading to proteasome-mediated degradation of H2AX. Genetically, loss of H2AX or overexpression of AFB1 suppresses the DDR defects of the mail3 mutant. Taken together, this study identifies MAIL3 and SCFAFB1 as the first phosphatase and the first E3 ubiquitin ligase, respectively, that regulate H2AX in plants, highlighting the critical role of H2AX dephosphorylation and polyubiquitination in DDR termination.","PeriodicalId":19012,"journal":{"name":"Molecular Plant","volume":" ","pages":"987-1002"},"PeriodicalIF":24.1,"publicationDate":"2026-05-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145863869","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Population epigenomics reveals epigenetic drivers of replicated evolution and missing heritability in soybean. 群体表观基因组学揭示了大豆重复进化和遗传缺失的表观遗传驱动因素。

IF 24.1 1区生物学

Molecular Plant Pub Date : 2026-05-04 Epub Date: 2026-02-27 DOI: 10.1016/j.molp.2026.02.013

Xinyu Jiang, Mengzhu Zhang, Xiaobo Yuan, Longfei Wang, Wu Jiao, Junrong Mao, Wenxue Ye, Deyue Yu, Zhixi Tian, Qingxin Song

{"title":"Population epigenomics reveals epigenetic drivers of replicated evolution and missing heritability in soybean.","authors":"Xinyu Jiang, Mengzhu Zhang, Xiaobo Yuan, Longfei Wang, Wu Jiao, Junrong Mao, Wenxue Ye, Deyue Yu, Zhixi Tian, Qingxin Song","doi":"10.1016/j.molp.2026.02.013","DOIUrl":"10.1016/j.molp.2026.02.013","url":null,"abstract":"Heritable epimutations can lead to transmissible phenotypic variation. However, the contribution of epigenetic variations to phenotypic diversity in plant evolution and crop domestication remains elusive. In this study, we constructed a comprehensive DNA methylation atlas of 1102 soybean accessions, including wild soybeans, landraces, and improved cultivars. Integrated analysis of the methylome, variome, and transcriptome revealed that de novo epimutations contributed to increased epigenetic diversity following the domestication bottleneck and modulated gene expression during soybean evolution. An epigenome-wide association study and targeted DNA methylation editing validated an epiallele governing the expression of GmFT5a, which contributed to the replicated evolution of earlier flowering during high-latitude adaptation in both wild and cultivated soybeans. Notably, integrating genetic and epigenetic variants substantially increased the proportion of phenotypic variance explained, capturing a larger fraction of the heritability of these agronomic traits. This study emphasizes the considerable potential of epialleles for crop improvement and may pave the way for epigenetics-driven breeding.","PeriodicalId":19012,"journal":{"name":"Molecular Plant","volume":" ","pages":"1100-1116"},"PeriodicalIF":24.1,"publicationDate":"2026-05-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147321868","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

FT florigen proteins in photoperiodic signaling: Conservation and diversity in their regulation, structure, and function. 光周期信号中的FT成花蛋白：调控、结构和功能的保守性和多样性。

IF 24.1 1区生物学

Molecular Plant Pub Date : 2026-05-04 Epub Date: 2026-03-20 DOI: 10.1016/j.molp.2026.03.002

He Gao, Na Ding, Yuang Wu, George Coupland

{"title":"FT florigen proteins in photoperiodic signaling: Conservation and diversity in their regulation, structure, and function.","authors":"He Gao, Na Ding, Yuang Wu, George Coupland","doi":"10.1016/j.molp.2026.03.002","DOIUrl":"10.1016/j.molp.2026.03.002","url":null,"abstract":"Seasonal changes in day length regulate plant growth and development. FLOWERING LOCUS T (FT) proteins are widely conserved effectors of photoperiod-induced flowering and also promote tuberization in potato and bud growth in trees. We integrate data from several model and crop species to illustrate the major features of FT function and regulation. The day lengths that induce developmental responses differ among species, and diverse examples are selected to show how this is conferred by photoperiod-dependent FT transcription in leaf vasculature. FT protein movement into the phloem sieve elements and to the shoot apical meristem is then described. The functionally important domains of FT and how they contribute to a transcriptional complex with bZIP transcription factors and 14-3-3 proteins are outlined. Functional FT is contrasted with diverged FT paralogs and related TERMINAL FLOWER 1 proteins that act as negative regulators of FT activity to modulate developmental responses. A relay mechanism in which FT genes or closely related paralogs are transcriptionally induced at the shoot apex after the arrival of FT protein is described in cereals, tomato, and Arabidopsis and in the stolon of potato We argue that this mechanism plays a role in sustaining photoperiod-induced developmental transitions. Finally, we discuss unresolved questions in FT signaling and how these might be addressed.","PeriodicalId":19012,"journal":{"name":"Molecular Plant","volume":" ","pages":"964-986"},"PeriodicalIF":24.1,"publicationDate":"2026-05-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147494061","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

High-density cultivation of synthetic apomictic hybrid rice achieves near-complete diploidization and parental-equivalent yield in field trials. 在田间试验中，高密度栽培的合成无杂交水稻实现了近完全二倍体化和亲本当量产量。

IF 24.1 1区生物学

Molecular Plant Pub Date : 2026-05-04 Epub Date: 2026-03-20 DOI: 10.1016/j.molp.2026.03.012

Mengqiu Song, Shengnan Li, Zuan Wang, Guojun Dong, Tao Wang, Jingxi Sun, Siqi Xia, Zeyuan Yang, Weizhe Liu, Youlin Peng, Longjiang Fan, Jian Sun, Yong Zhang, Kejian Wang, Xiaoming Zheng, Qian Qian

引用次数: 0

Green Revolution-associated DELLA accumulation enhances salt tolerance in cereals by disrupting INDETERMINATE SPIKELET1 biomolecular condensates. 绿色革命相关的DELLA积累通过破坏INDETERMINATE SPIKELET1生物分子凝聚物增强了谷物的耐盐性。

IF 24.1 1区生物学

Molecular Plant Pub Date : 2026-05-04 Epub Date: 2026-04-15 DOI: 10.1016/j.molp.2026.03.008

Xiliu Cheng, Haoran Wang, Mingjie Lyu, Meiting Gao, Guogen Zhang, Yanjia Gong, Yanqing Chen, Xianjun Sun, Xiaoding Ma, Weihua Qiao, Fan Zhang, Jun Liu, Jie Liu

{"title":"Green Revolution-associated DELLA accumulation enhances salt tolerance in cereals by disrupting INDETERMINATE SPIKELET1 biomolecular condensates.","authors":"Xiliu Cheng, Haoran Wang, Mingjie Lyu, Meiting Gao, Guogen Zhang, Yanjia Gong, Yanqing Chen, Xianjun Sun, Xiaoding Ma, Weihua Qiao, Fan Zhang, Jun Liu, Jie Liu","doi":"10.1016/j.molp.2026.03.008","DOIUrl":"10.1016/j.molp.2026.03.008","url":null,"abstract":"The semi-dwarf cereal varieties bred during the Green Revolution revolutionized global agriculture under optimal growing conditions, but their performance in stressful environments-, particularly under soil salinity, has remained an unresolved paradox. Here, we show that Green Revolution varieties (GRVs) of rice and wheat exhibit significantly enhanced salt tolerance compared with their pre-Green Revolution cultivated counterparts (non-GRVs), mediated by stress-induced accumulation of DELLA proteins. Through integrated metabolomic and transcriptomic analyses, we demonstrate that DELLAs maintain \"growth-stress\" balance by rewiring sugar-amino acid metabolic networks. At the molecular level, DELLAs antagonize INDETERMINATE SPIKELET1 (IDS1), a growth-promoting transcription factor that impairs salt tolerance through biomolecular condensation. Structural and functional analyses demonstrate that DELLAs physically dissolve IDS1 condensates, thereby reprogramming transcriptional networks. Remarkably, expression of a dominant-negative OsIDS1 variant (OsIDS1EARm), which attenuates condensation and transcriptional repression, confers both semi-dwarf architecture and enhanced salt tolerance in non-GRVs, outperforming conventional Green Revolution alleles by producing a 35% yield gain (∼170 kg ha⁻¹) in saline fields. Collectively, our work resolves the mechanistic basis of stress adaptation in semi-dwarf crops and establishes a novel paradigm for the development of stress-resilient crops through targeted manipulation of transcriptional condensates.","PeriodicalId":19012,"journal":{"name":"Molecular Plant","volume":" ","pages":"1059-1079"},"PeriodicalIF":24.1,"publicationDate":"2026-05-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147699054","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0