植物免疫系统依赖于激活和抑制之间精确平衡的相互作用,以有效地对抗病原体而不引起自我伤害。水杨酸(SA)信号通路是该系统的基石,目前正在经历研究复兴。具有里程碑意义的研究最近阐明了从choris酸盐和苯丙氨酸合成SA的完整酶促途径(Liu et al., 2025; Wang et al., 2025; Zhu et al., 2025),而结构生物学的进展已经解决了关键信号成分的原子水平结构(Kumar et al., 2022)。这个网络的核心是由致病相关基因的非表达者编码的NPR蛋白。在这个家族中,NPR1是防御基因的主要转录共激活因子。相反,其类似物NPR3和NPR4作为转录共抑制因子,可减弱应答,防止异常免疫激活和相关资源分配(Ding et al., 2018)。这些调节蛋白的动态周转是免疫稳态的基础,但控制抑制物降解的专用机制仍然部分难以捉摸。
期刊介绍:
Molecular Plant is dedicated to serving the plant science community by publishing novel and exciting findings with high significance in plant biology. The journal focuses broadly on cellular biology, physiology, biochemistry, molecular biology, genetics, development, plant-microbe interaction, genomics, bioinformatics, and molecular evolution.
Molecular Plant publishes original research articles, reviews, Correspondence, and Spotlights on the most important developments in plant biology.