Journal of Diabetes最新文献

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The combined effect of triglyceride–glucose index and high-sensitivity C-reactive protein on cardiovascular outcomes in patients with chronic coronary syndrome: A multicenter cohort study 甘油三酯-葡萄糖指数和高敏 C 反应蛋白对慢性冠状动脉综合征患者心血管预后的联合影响:一项多中心队列研究。
IF 3 2区 医学
Journal of Diabetes Pub Date : 2024-08-13 DOI: 10.1111/1753-0407.13589
Qinxue Li, Ying Song, Zheng Zhang, Jingjing Xu, Zhenyu Liu, Xiaofang Tang, Xiaozeng Wang, Yan Chen, Yongzhen Zhang, Pei Zhu, Xiaogang Guo, Lin Jiang, Zhifang Wang, Ru Liu, Qingsheng Wang, Yi Yao, Yingqing Feng, Yaling Han, Jinqing Yuan
{"title":"The combined effect of triglyceride–glucose index and high-sensitivity C-reactive protein on cardiovascular outcomes in patients with chronic coronary syndrome: A multicenter cohort study","authors":"Qinxue Li,&nbsp;Ying Song,&nbsp;Zheng Zhang,&nbsp;Jingjing Xu,&nbsp;Zhenyu Liu,&nbsp;Xiaofang Tang,&nbsp;Xiaozeng Wang,&nbsp;Yan Chen,&nbsp;Yongzhen Zhang,&nbsp;Pei Zhu,&nbsp;Xiaogang Guo,&nbsp;Lin Jiang,&nbsp;Zhifang Wang,&nbsp;Ru Liu,&nbsp;Qingsheng Wang,&nbsp;Yi Yao,&nbsp;Yingqing Feng,&nbsp;Yaling Han,&nbsp;Jinqing Yuan","doi":"10.1111/1753-0407.13589","DOIUrl":"10.1111/1753-0407.13589","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Background</h3>\u0000 \u0000 <p>The triglyceride–glucose (TyG) index and high-sensitivity C-reactive protein (hsCRP) are the commonly used biomarkers for insulin resistance and systemic inflammation, respectively. We aimed to investigate the combined association of TyG and hsCRP with the major adverse cardiovascular events (MACE) in patients with chronic coronary syndrome (CCS).</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>A total of 9421 patients with CCS were included in this study. The primary endpoint was defined as a composite of MACE covering all-cause death, nonfatal myocardial infarction, and revascularization.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>During the 2-year follow-up period, 660 (7.0%) cases of MACE were recorded. Participants were divided equally into three groups according to TyG levels. Compared with the TyG T1 group, the risk of MACE was significantly higher in the TyG T3 group. It is noteworthy that among patients in the highest tertile of TyG, hsCRP &gt;3 mg/L was significantly associated with an increased risk of MACE, whereas the results were not significant in the medium to low TyG groups. When patients were divided into six groups according to hsCRP and TyG, the Cox regression analysis showed that patients in the TyG T3 and hsCRP &gt;3 mg/L group had a significantly higher risk of MACE than those in the TyG T1 and hsCRP ≤3 mg/L group. However, no significant interaction was found between TyG and hsCRP on the risk of MACE.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>Our study suggests that the concurrent assessment of TyG and hsCRP may be valuable in identifying high-risk populations and guiding management strategies among CCS patients.</p>\u0000 \u0000 <div>\u0000 <figure>\u0000 <div><picture>\u0000 <source></source></picture><p></p>\u0000 </div>\u0000 </figure>\u0000 </div>\u0000 </section>\u0000 </div>","PeriodicalId":189,"journal":{"name":"Journal of Diabetes","volume":"16 8","pages":""},"PeriodicalIF":3.0,"publicationDate":"2024-08-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/1753-0407.13589","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141970227","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The efficacy of interventions to prevent type 2 diabetes among women with recent gestational diabetes mellitus—A living systematic review and meta-analysis 对近期妊娠糖尿病妇女采取干预措施预防 2 型糖尿病的效果--活体系统综述和荟萃分析。
IF 3 2区 医学
Journal of Diabetes Pub Date : 2024-08-13 DOI: 10.1111/1753-0407.13590
Vivian Y. Lee, Mohammad R. Monjur, Joseph Alvin Santos, Anushka Patel, Rong Liu, Gian Luca Di Tanna, Yashdeep Gupta, Alpesh Goyal, Saumiyah Ajanthan, Devarsetty Praveen, J. K. Lakshmi, H. Asita de Silva, Nikhil Tandon
{"title":"The efficacy of interventions to prevent type 2 diabetes among women with recent gestational diabetes mellitus—A living systematic review and meta-analysis","authors":"Vivian Y. Lee,&nbsp;Mohammad R. Monjur,&nbsp;Joseph Alvin Santos,&nbsp;Anushka Patel,&nbsp;Rong Liu,&nbsp;Gian Luca Di Tanna,&nbsp;Yashdeep Gupta,&nbsp;Alpesh Goyal,&nbsp;Saumiyah Ajanthan,&nbsp;Devarsetty Praveen,&nbsp;J. K. Lakshmi,&nbsp;H. Asita de Silva,&nbsp;Nikhil Tandon","doi":"10.1111/1753-0407.13590","DOIUrl":"10.1111/1753-0407.13590","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Background</h3>\u0000 \u0000 <p>While previously considered a transient condition, with no lasting adverse impact, gestational diabetes mellitus (GDM) is now a well-established risk factor for developing type 2 diabetes mellitus (T2DM). The risk of developing T2DM appears to be particularly high in the first few years after childbirth, providing a compelling case for early intervention. This review provides an up-to-date systematic review and meta-analysis to assess the effectiveness of interventions to reduce incidence of T2DM in women with a recent history of GDM.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>The search was conducted on October 20, 2023 with an annual surveillance planned for the next 5 years to maintain a living systematic review. The inclusion criteria were randomized controlled trials of any type in women within 5 years of GDM-complicated pregnancy that reported outcomes of T2DM diagnosis or measures of dysglycemia with a follow-up of at least 12 months.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Seventeen studies met our inclusion criteria and have been included in this review. There were 3 pharmacological and 14 lifestyle interventions. Intervention was not associated with significant reduction in the primary outcome of T2DM (risk ratio, 0.78; 95% confidence interval [CI]: 0.43–1.41; <i>p</i> = 0.41; <i>I</i><sup>2</sup> = 79%) compared with the control group (placebo or usual care). However, meta-analysis of the four studies reporting hazard ratios suggested a reduction in diabetes incidence (hazard ratio, 0.68; 95% CI: 0.48–0.97; <i>p</i> = 0.03; <i>I</i><sup>2</sup> = 31%).</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>This review provides equivocal evidence about the efficacy of interventions to reduce the risk of T2DM in women within 5 years of GDM-complicated pregnancy and highlights the need for further studies, including pharmacotherapy.</p>\u0000 \u0000 <div>\u0000 <figure>\u0000 <div><picture>\u0000 <source></source></picture><p></p>\u0000 </div>\u0000 </figure>\u0000 </div>\u0000 </section>\u0000 </div>","PeriodicalId":189,"journal":{"name":"Journal of Diabetes","volume":"16 8","pages":""},"PeriodicalIF":3.0,"publicationDate":"2024-08-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/1753-0407.13590","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141970228","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Association between estimated glucose disposal rate control level and stroke incidence in middle-aged and elderly adults 中老年人估计葡萄糖处置率控制水平与中风发病率之间的关系。
IF 3 2区 医学
Journal of Diabetes Pub Date : 2024-08-13 DOI: 10.1111/1753-0407.13595
Jiangnan Yao, Feng Zhou, Lingzhi Ruan, Yiling Liang, Qianrong Zheng, Jiaxin Shao, Fuman Cai, Jianghua Zhou, Hao Zhou
{"title":"Association between estimated glucose disposal rate control level and stroke incidence in middle-aged and elderly adults","authors":"Jiangnan Yao,&nbsp;Feng Zhou,&nbsp;Lingzhi Ruan,&nbsp;Yiling Liang,&nbsp;Qianrong Zheng,&nbsp;Jiaxin Shao,&nbsp;Fuman Cai,&nbsp;Jianghua Zhou,&nbsp;Hao Zhou","doi":"10.1111/1753-0407.13595","DOIUrl":"10.1111/1753-0407.13595","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Background</h3>\u0000 \u0000 <p>To estimate glucose disposal rate (eGDR) as a newly validated surrogate marker of insulin resistance. Few studies have explored the association between changes in eGDR levels and stroke incidence. This study aims to explore the effect of the level of eGDR control on stroke and events.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>Data were obtained from the China Longitudinal Study on Health and Retirement (CHARLS). The eGDR control level was classified using K-means cluster analysis. Logistic regression analysis was used to explore the association between different eGDR control levels and incident stroke. Restrictive cubic spline regression was used to test the potential nonlinear association between cumulative eGDR and stroke incidence.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Of the 4790 participants, 304 (6.3%) had a stroke within 3 years. The odds ratio (OR) was 2.34 (95% confidence interval [CI], 1.42–3.86) for the poorly controlled class 4 and 2.56 (95% CI, 1.53–4.30) for the worst controlled class 5 compared with class 1 with the best controlled eGDR. The OR for well-controlled class 2 was 1.28 (95% CI, 0.79–2.05), and the OR for moderately controlled class 3 was 1.95 (95% CI, 1.14–3.32). In restrictive cubic spline regression analysis, eGDR changes are linearly correlated with stroke occurrence. Weighted quartile and regression analysis identified waist circumference and hypertension as key variables of eGDR for predicting incident stroke.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>Poorly controlled eGDR level is associated with an increased risk of stroke in middle-aged and elderly people. Monitoring changes in eGDR may help identify individuals at high risk of stroke early.</p>\u0000 \u0000 <div>\u0000 <figure>\u0000 <div><picture>\u0000 <source></source></picture><p></p>\u0000 </div>\u0000 </figure>\u0000 </div>\u0000 </section>\u0000 </div>","PeriodicalId":189,"journal":{"name":"Journal of Diabetes","volume":"16 8","pages":""},"PeriodicalIF":3.0,"publicationDate":"2024-08-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/1753-0407.13595","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141970222","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Clinical characteristics and complication risks in data-driven clusters among Chinese community diabetes populations 中国社区糖尿病人群数据驱动集群的临床特征和并发症风险。
IF 3 2区 医学
Journal of Diabetes Pub Date : 2024-08-13 DOI: 10.1111/1753-0407.13596
Binqi Li, Zizhong Yang, Yang Liu, Xin Zhou, Weiqing Wang, Zhengnan Gao, Li Yan, Guijun Qin, Xulei Tang, Qin Wan, Lulu Chen, Zuojie Luo, Guang Ning, Weijun Gu, Yiming Mu
{"title":"Clinical characteristics and complication risks in data-driven clusters among Chinese community diabetes populations","authors":"Binqi Li,&nbsp;Zizhong Yang,&nbsp;Yang Liu,&nbsp;Xin Zhou,&nbsp;Weiqing Wang,&nbsp;Zhengnan Gao,&nbsp;Li Yan,&nbsp;Guijun Qin,&nbsp;Xulei Tang,&nbsp;Qin Wan,&nbsp;Lulu Chen,&nbsp;Zuojie Luo,&nbsp;Guang Ning,&nbsp;Weijun Gu,&nbsp;Yiming Mu","doi":"10.1111/1753-0407.13596","DOIUrl":"10.1111/1753-0407.13596","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Background</h3>\u0000 \u0000 <p>Novel diabetes phenotypes were proposed by the Europeans through cluster analysis, but Chinese community diabetes populations might exhibit different characteristics. This study aims to explore the clinical characteristics of novel diabetes subgroups under data-driven analysis in Chinese community diabetes populations.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>We used K-means cluster analysis in 6369 newly diagnosed diabetic patients from eight centers of the REACTION (Risk Evaluation of cAncers in Chinese diabeTic Individuals) study. The cluster analysis was performed based on age, body mass index, glycosylated hemoglobin, homeostatic modeled insulin resistance index, and homeostatic modeled pancreatic β-cell functionality index. The clinical features were evaluated with the analysis of variance (ANOVA) and chi-square test. Logistic regression analysis was done to compare chronic kidney disease and cardiovascular disease risks between subgroups.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Overall, 2063 (32.39%), 658 (10.33%), 1769 (27.78%), and 1879 (29.50%) populations were assigned to severe obesity-related and insulin-resistant diabetes (SOIRD), severe insulin-deficient diabetes (SIDD), mild age-associated diabetes mellitus (MARD), and mild insulin-deficient diabetes (MIDD) subgroups, respectively. Individuals in the MIDD subgroup had a low risk burden equivalent to prediabetes, but with reduced insulin secretion. Individuals in the SOIRD subgroup were obese, had insulin resistance, and a high prevalence of fatty liver, tumors, family history of diabetes, and tumors. Individuals in the SIDD subgroup had severe insulin deficiency, the poorest glycemic control, and the highest prevalence of dyslipidemia and diabetic nephropathy. Individuals in MARD subgroup were the oldest, had moderate metabolic dysregulation and the highest risk of cardiovascular disease.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>The data-driven approach to differentiating the status of new-onset diabetes in the Chinese community was feasible. Patients in different clusters presented different characteristics and risks of complications.</p>\u0000 \u0000 <div>\u0000 <figure>\u0000 <div><picture>\u0000 <source></source></picture><p></p>\u0000 </div>\u0000 </figure>\u0000 </div>\u0000 </section>\u0000 </div>","PeriodicalId":189,"journal":{"name":"Journal of Diabetes","volume":"16 8","pages":""},"PeriodicalIF":3.0,"publicationDate":"2024-08-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/1753-0407.13596","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141970223","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Probiotic treatment with viable α-galactosylceramide-producing Bacteroides fragilis reduces diabetes incidence in female nonobese diabetic mice 用能产生α-半乳糖酰胺的脆弱拟杆菌进行益生菌治疗可降低雌性非肥胖糖尿病小鼠的糖尿病发病率。
IF 3 2区 医学
Journal of Diabetes Pub Date : 2024-08-13 DOI: 10.1111/1753-0407.13593
Camilla H. F. Hansen, Danica Jozipovic, Line F. Zachariassen, Dennis S. Nielsen, Axel K. Hansen, Karsten Buschard
{"title":"Probiotic treatment with viable α-galactosylceramide-producing Bacteroides fragilis reduces diabetes incidence in female nonobese diabetic mice","authors":"Camilla H. F. Hansen,&nbsp;Danica Jozipovic,&nbsp;Line F. Zachariassen,&nbsp;Dennis S. Nielsen,&nbsp;Axel K. Hansen,&nbsp;Karsten Buschard","doi":"10.1111/1753-0407.13593","DOIUrl":"10.1111/1753-0407.13593","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Background</h3>\u0000 \u0000 <p>We aimed to investigate whether alpha-galactosylceramide (α-GalCer)-producing <i>Bacteroides fragilis</i> could induce natural killer T (NKT) cells in nonobese diabetic (NOD) mice and reduce their diabetes incidence.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>Five-week-old female NOD mice were treated orally with <i>B. fragilis</i>, and islet pathology and diabetes onset were monitored. Immune responses were analyzed by flow cytometry and multiplex technology. Effects of ultraviolet (UV)-killed α-GalCer-producing <i>B. fragilis</i> and their culture medium on invariant NKT (iNKT) cells were tested ex vivo on murine splenocytes, and the immunosuppressive capacity of splenocytes from <i>B. fragilis</i>-treated NOD mice were tested by adoptive transfer to nonobese diabetic/severe combined immunodeficiency (NOD/SCID) mice.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p><i>B. fragilis</i> reduced the diabetes incidence from 69% to 33% and the percent of islets with insulitis from 40% to 7%, which doubled the serum insulin level compared with the vehicle-treated control mice. Furthermore, the early treatment reduced proinflammatory mediators in the serum, whereas the proportion of CD4<sup>+</sup> NKT cell population was increased by 33%. <i>B. fragilis</i> growth media stimulated iNKT cells and anti-inflammatory M2 macrophages ex vivo in contrast to UV-killed bacteria, which had no effect, strongly indicating an α-GalCer-mediated effect. Adoptive transfer of splenocytes from <i>B. fragilis</i>-treated NOD mice induced a similar diabetes incidence as splenocytes from untreated NOD mice.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p><i>B. fragilis</i> induced iNKT cells and M2 macrophages and reduced type 1 diabetes in NOD mice. The protective effect seemed to be more centered on gut–pancreas interactions rather than a systemic immunosuppression. <i>B. fragilis</i> should be considered for probiotic use in individuals at risk of developing type 1 diabetes.</p>\u0000 \u0000 <div>\u0000 <figure>\u0000 <div><picture>\u0000 <source></source></picture><p></p>\u0000 </div>\u0000 </figure>\u0000 </div>\u0000 </section>\u0000 </div>","PeriodicalId":189,"journal":{"name":"Journal of Diabetes","volume":"16 8","pages":""},"PeriodicalIF":3.0,"publicationDate":"2024-08-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/1753-0407.13593","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141970225","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Remnant cholesterol is more positively related to diabetes, prediabetes, and insulin resistance than conventional lipid parameters and lipid ratios: A multicenter, large sample survey 残余胆固醇与糖尿病、糖尿病前期和胰岛素抵抗的正相关性高于常规血脂参数和血脂比率:一项多中心、大样本调查。
IF 3 2区 医学
Journal of Diabetes Pub Date : 2024-08-13 DOI: 10.1111/1753-0407.13592
Binqi Li, Yang Liu, Xin Zhou, Lulu Chen, Li Yan, Xulei Tang, Zhengnan Gao, Qin Wan, Zuojie Luo, Guijun Qin, Guang Ning, Weijun Gu, Yiming Mu
{"title":"Remnant cholesterol is more positively related to diabetes, prediabetes, and insulin resistance than conventional lipid parameters and lipid ratios: A multicenter, large sample survey","authors":"Binqi Li,&nbsp;Yang Liu,&nbsp;Xin Zhou,&nbsp;Lulu Chen,&nbsp;Li Yan,&nbsp;Xulei Tang,&nbsp;Zhengnan Gao,&nbsp;Qin Wan,&nbsp;Zuojie Luo,&nbsp;Guijun Qin,&nbsp;Guang Ning,&nbsp;Weijun Gu,&nbsp;Yiming Mu","doi":"10.1111/1753-0407.13592","DOIUrl":"10.1111/1753-0407.13592","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Background</h3>\u0000 \u0000 <p>Not many large-sample investigations are available that compare the potency of the relationship of remnant cholesterol (RC) and other lipid parameters with diabetes and prediabetes. The goals of our study are to discover the relationship between RC and prediabetes, diabetes, and insulin resistance (IR) and to investigate RC, high-density lipoprotein cholesterol (HDL-C), non-HDL-C, triglycerides (TG), low-density lipoprotein cholesterol (LDL-C), total cholesterol (TC), TC/HDL-C, LDL-C/HDL-C, and TG/HDL-C, which are the lipid parameters that are most positively related to diabetes, prediabetes, and IR.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>This research enrolled 36 684 subjects from China's eight provinces. We employed multiple logistic regression analysis for testing the relationship between lipid parameters and diabetes, prediabetes, and IR.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>After adjusting for potential confounders, and comparing the results with other lipid parameters, the positive relationship between RC and diabetes (odds ratio [OR] 1.417, 95% confidence interval [CI]: 1.345–1.492), prediabetes (OR 1.555, 95% CI: 1.438–1.628), and IR (OR 1.488, 95% CI: 1.404–1.577) was highest. RC was still related to diabetes, prediabetes, and IR even when TG &lt;2.3 mmol/L (diabetes: OR 1.256, 95% CI: 1.135–1.390; prediabetes: OR 1.503, 95% CI: 1.342–1.684; and IR: OR 1.278, 95% CI: 1.140–1.433), LDL-C &lt;2.6 mmol/L (diabetes: OR 1.306, 95% CI: 1.203–1.418; prediabetes: OR 1.597, 95% CI: 1.418–1.798; and IR: OR 1.552, 95% CI: 1.416–1.701), or HDL-C ≥1 mmol/L (diabetes: OR 1.456, 95% CI: 1.366–1.550; prediabetes: OR 1.553, 95% CI: 1.421–1.697; and IR: OR 1.490, 95% CI: 1.389–1.598).</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>RC is more positively related to diabetes, prediabetes, and IR than conventional lipids and lipid ratios in the general population, the relationships between RC and diabetes, prediabetes, and IR are stable, even if HDL-C, LDL-C, or TG are at appropriate levels.</p>\u0000 \u0000 <div>\u0000 <figure>\u0000 <div><picture>\u0000 <source></source></picture><p></p>\u0000 </div>\u0000 </figure>\u0000 </div>\u0000 </section>\u0000 </div>","PeriodicalId":189,"journal":{"name":"Journal of Diabetes","volume":"16 8","pages":""},"PeriodicalIF":3.0,"publicationDate":"2024-08-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/1753-0407.13592","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141970226","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Trends in diabetic ketoacidosis- and hyperosmolar hyperglycemic state-related mortality during the COVID-19 pandemic in the United States: A population-based study 美国 COVID-19 大流行期间与糖尿病酮症酸中毒和高渗性高血糖状态相关的死亡率趋势:基于人群的研究。
IF 3 2区 医学
Journal of Diabetes Pub Date : 2024-08-13 DOI: 10.1111/1753-0407.13591
Xinyuan He, Amy Huaishiuan Huang, Fan Lv, Xu Gao, Yuxin Guo, Yishan Liu, Xiaoqin Hu, Jingyi Xie, Ning Gao, Yang Jiao, Yuan Wang, Jian Zu, Lei Zhang, Fanpu Ji, Yee Hui Yeo
{"title":"Trends in diabetic ketoacidosis- and hyperosmolar hyperglycemic state-related mortality during the COVID-19 pandemic in the United States: A population-based study","authors":"Xinyuan He,&nbsp;Amy Huaishiuan Huang,&nbsp;Fan Lv,&nbsp;Xu Gao,&nbsp;Yuxin Guo,&nbsp;Yishan Liu,&nbsp;Xiaoqin Hu,&nbsp;Jingyi Xie,&nbsp;Ning Gao,&nbsp;Yang Jiao,&nbsp;Yuan Wang,&nbsp;Jian Zu,&nbsp;Lei Zhang,&nbsp;Fanpu Ji,&nbsp;Yee Hui Yeo","doi":"10.1111/1753-0407.13591","DOIUrl":"10.1111/1753-0407.13591","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Background</h3>\u0000 \u0000 <p>During the pandemic, a notable increase in diabetic ketoacidosis (DKA) and hyperosmolar hyperglycemic state (HHS), conditions that warrant emergent management, was reported. We aimed to investigate the trend of DKA- and HHS-related mortality and excess deaths during the pandemic.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>Annual age-standardized mortality rates related to DKA and HHS between 2006 and 2021 were estimated using a nationwide database. Forecast analyses based on prepandemic data were conducted to predict the mortality rates during the pandemic. Excess mortality rates were calculated by comparing the observed versus predicted mortality rates. Subgroup analyses of demographic factors were performed.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>There were 71 575 DKA-related deaths and 8618 HHS-related deaths documented during 2006–2021. DKA, which showed a steady increase before the pandemic, demonstrated a pronounced excess mortality during the pandemic (36.91% in 2020 and 46.58% in 2021) with an annual percentage change (APC) of 29.4% (95% CI: 16.0%–44.0%). Although HHS incurred a downward trend during 2006–2019, the excess deaths in 2020 (40.60%) and 2021 (56.64%) were profound. Pediatric decedents exhibited the highest excess mortality. More than half of the excess deaths due to DKA were coronavirus disease 2019 (COVID-19) related (51.3% in 2020 and 63.4% in 2021), whereas only less than a quarter of excess deaths due to HHS were COVID-19 related. A widened racial/ethnic disparity was observed, and females exhibited higher excess mortality than males.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>The DKA- and HHS-related excess mortality during the pandemic and relevant disparities emphasize the urgent need for targeted strategies to mitigate the escalated risk in these populations during public health crises.</p>\u0000 \u0000 <div>\u0000 <figure>\u0000 <div><picture>\u0000 <source></source></picture><p></p>\u0000 </div>\u0000 </figure>\u0000 </div>\u0000 </section>\u0000 </div>","PeriodicalId":189,"journal":{"name":"Journal of Diabetes","volume":"16 8","pages":""},"PeriodicalIF":3.0,"publicationDate":"2024-08-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/1753-0407.13591","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141970229","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Imelda Lee—A memorial note 伊梅尔达-李-纪念笔记
IF 3 2区 医学
Journal of Diabetes Pub Date : 2024-07-29 DOI: 10.1111/1753-0407.13606
Zachary Bloomgarden
{"title":"Imelda Lee—A memorial note","authors":"Zachary Bloomgarden","doi":"10.1111/1753-0407.13606","DOIUrl":"10.1111/1753-0407.13606","url":null,"abstract":"<p>Imelda Lee was one of the most important members of the <i>Journal of Diabetes</i> team—our founding administrator. Imelda started the <i>Journal of Diabetes</i> group with all of us more than 15 years ago. We pay attention to the scientists and physicians who nominally “run” the Journal, but it would be wrong to overlook those crucial to the daily operations “behind-the-scenes.”</p><p>Imelda grew up in Hong Kong in the early 1950s, and her sisters Lee and Frances remembered her to us as a fierce protector of all her family throughout her youth. After her secondary education, she worked in Hong Kong, then moved to the United States, and while working with her family at their business in Indiana, she was also able to attend and graduate from Purdue University, much to the admiration of those who knew her. She returned to China and moved to Shanghai, where she became an administrator at Rui Jin Hospital. She was recruited to manage the <i>Journal of Diabetes</i> as it was being started, when one of us (Z.B.) had the pleasure of meeting her. The same fierce spirit that led to her defending her siblings in Hong Kong and to her both working and going to college at night in the United States, led to her wonderful work at the new Journal. The impact of her administrative work was felt by all of us and by the editorial group; being both in China and in the United States, she was able to literally keep us going “24 × 7.” She challenged all of us to work harder, to learn the quirks of the Journal's complex computer system, and to reach out to the world of diabetes research to help develop the Journal in its formative period. She was quiet unless there was an issue, but then she would be fierce in helping all of us to accomplish more.</p><p>The Biblical term <i>Eshet Chayil</i> is usually translated as “Woman of Valor,” but has multiple meanings, referring as well to capacity and power, and Imelda was indeed a woman of true inner strength who exemplified wisdom and industry in her professional endeavors. Above all, she was guided by a strong moral compass, following a basic set of principles, accepting our efforts and uplifting and empowering us, and leaving us better for being her colleagues. Her active and optimistic attitude toward difficulties also greatly influenced us, with her readiness to help others a model for all to emulate. Imelda's deep faith was always an inspiring example to us but never more so than when she became ill several years ago. We did not hear words of unhappiness or despair; rather, she exemplified courage in the face of adversity.</p><p>We remember her, and we deeply miss her. As much as any of us, Imelda truly was a founder of the Journal, and we hope that the concept of the <i>Journal of Diabetes</i> in supporting a dialog between East and West in all aspects of the understanding of diabetes will continue as a memorial to her efforts.</p>","PeriodicalId":189,"journal":{"name":"Journal of Diabetes","volume":"16 7","pages":""},"PeriodicalIF":3.0,"publicationDate":"2024-07-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11284314/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141786631","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The relationships between biological novel biomarkers Lp-PLA2 and CTRP-3 and CVD in patients with type 2 diabetes mellitus 新型生物标记物 Lp-PLA2 和 CTRP-3 与 2 型糖尿病患者心血管疾病之间的关系。
IF 3 2区 医学
Journal of Diabetes Pub Date : 2024-06-26 DOI: 10.1111/1753-0407.13574
Yanhong Chen, Shixin Wang, Jian Li, Yu Fu, Pengsheng Chen, Xuekui Liu, Jiao Zhang, Li Sun, Rui Zhang, Xiaoli Li, Lingling Liu
{"title":"The relationships between biological novel biomarkers Lp-PLA2 and CTRP-3 and CVD in patients with type 2 diabetes mellitus","authors":"Yanhong Chen,&nbsp;Shixin Wang,&nbsp;Jian Li,&nbsp;Yu Fu,&nbsp;Pengsheng Chen,&nbsp;Xuekui Liu,&nbsp;Jiao Zhang,&nbsp;Li Sun,&nbsp;Rui Zhang,&nbsp;Xiaoli Li,&nbsp;Lingling Liu","doi":"10.1111/1753-0407.13574","DOIUrl":"10.1111/1753-0407.13574","url":null,"abstract":"&lt;div&gt;\u0000 \u0000 \u0000 &lt;section&gt;\u0000 \u0000 &lt;h3&gt; Background&lt;/h3&gt;\u0000 \u0000 &lt;p&gt;Cardiovascular disease (CVD) is recognized as a primary and severe comorbidity in patients with type 2 diabetes mellitus (T2DM) and is also identified as a leading cause of mortality within this population. Consequently, the identification of novel biomarkers for the risk stratification and progression of CVD in individuals with T2DM is of critical importance.&lt;/p&gt;\u0000 &lt;/section&gt;\u0000 \u0000 &lt;section&gt;\u0000 \u0000 &lt;h3&gt; Methods&lt;/h3&gt;\u0000 \u0000 &lt;p&gt;This retrospective cohort study encompassed 979 patients diagnosed with T2DM, of whom 116 experienced CVD events during the follow-up period. Clinical assessments and comprehensive blood laboratory analyses were conducted. Age- and sex-adjusted Cox proportional hazard regression analysis was utilized to evaluate the association between lipoprotein-associated phospholipase A&lt;sub&gt;2&lt;/sub&gt; (Lp-PLA&lt;sub&gt;2&lt;/sub&gt;), C1q/tumor necrosis factor-related protein 3 (CTRP-3), and the incidence of CVD in T2DM. The diagnostic performance of these biomarkers was assessed through receiver operating characteristic (ROC) curve analysis and the computation of the area under the curve (AUC).&lt;/p&gt;\u0000 &lt;/section&gt;\u0000 \u0000 &lt;section&gt;\u0000 \u0000 &lt;h3&gt; Results&lt;/h3&gt;\u0000 \u0000 &lt;p&gt;Over a median follow-up of 84 months (interquartile range: 42 [32–54] months), both novel inflammatory markers, Lp-PLA&lt;sub&gt;2&lt;/sub&gt; and CTRP-3, and traditional lipid indices, such as low-density lipoprotein cholesterol and apolipoprotein B, exhibited aberrant expression in the CVD-afflicted subset of the T2DM cohort. Age- and sex-adjusted Cox regression analysis delineated that Lp-PLA&lt;sub&gt;2&lt;/sub&gt; (hazard ratio [HR] = 1.007 [95% confidence interval {CI}: 1.005–1.009], &lt;i&gt;p&lt;/i&gt; &lt; 0.001) and CTRP-3 (HR = 0.943 [95% CI: 0.935–0.954], &lt;i&gt;p&lt;/i&gt; &lt; 0.001) were independently associated with the manifestation of CVD in T2DM. ROC curve analysis indicated a substantial predictive capacity for Lp-PLA&lt;sub&gt;2&lt;/sub&gt; (AUC = 0.81 [95% CI: 0.77–0.85], &lt;i&gt;p&lt;/i&gt; &lt; 0.001) and CTRP-3 (AUC = 0.91 [95% CI: 0.89–0.93], &lt;i&gt;p&lt;/i&gt; &lt; 0.001) in forecasting CVD occurrence in T2DM. The combined biomarker approach yielded an AUC of 0.94 (95% CI: 0.93–0.96), &lt;i&gt;p&lt;/i&gt; &lt; 0.001, indicating enhanced diagnostic accuracy.&lt;/p&gt;\u0000 &lt;/section&gt;\u0000 \u0000 &lt;section&gt;\u0000 \u0000 &lt;h3&gt; Conclusions&lt;/h3&gt;\u0000 \u0000 &lt;p&gt;The findings suggest that the biomarkers Lp-PLA&lt;sub&gt;2&lt;/sub&gt; and CTRP-3 are dysregulated in patients with T2DM who develop CVD and that each biomarker is independently associated with the occurrence of CVD. The combined assessment of Lp-PLA&lt;sub&gt;2&lt;/sub&gt; and CTRP-3 may significantly augment the diagnostic precision for CVD in the T2DM demographic.&lt;/p&gt;\u0000 ","PeriodicalId":189,"journal":{"name":"Journal of Diabetes","volume":"16 7","pages":""},"PeriodicalIF":3.0,"publicationDate":"2024-06-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11199973/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141454187","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Are sodium-glucose cotransporter-2 inhibitors safe adjunctive drugs during insulin therapy in young children with type 1 diabetes? The first case of type 1 diabetes with SLC5A2 mutation 钠-葡萄糖共转运体-2 抑制剂是 1 型糖尿病幼儿胰岛素治疗期间的安全辅助药物吗?首例 SLC5A2 基因突变的 1 型糖尿病患者。
IF 3 2区 医学
Journal of Diabetes Pub Date : 2024-06-26 DOI: 10.1111/1753-0407.13570
Mohamad Ahangar Davoodi, Mohammad Ali Daneshmand, Taraneh Rezaei
{"title":"Are sodium-glucose cotransporter-2 inhibitors safe adjunctive drugs during insulin therapy in young children with type 1 diabetes? The first case of type 1 diabetes with SLC5A2 mutation","authors":"Mohamad Ahangar Davoodi,&nbsp;Mohammad Ali Daneshmand,&nbsp;Taraneh Rezaei","doi":"10.1111/1753-0407.13570","DOIUrl":"10.1111/1753-0407.13570","url":null,"abstract":"<p><b>Highlights</b></p><p>\u0000 </p>","PeriodicalId":189,"journal":{"name":"Journal of Diabetes","volume":"16 7","pages":""},"PeriodicalIF":3.0,"publicationDate":"2024-06-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11200015/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141454184","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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