{"title":"糖尿病前期和2型糖尿病患者循环Gremlin 2与β-细胞功能的关系","authors":"Mengshan Ni, Yanru Chen, Weiqiong Gu, Yifei Zhang, Min Xu, Yanyun Gu, Yufei Chen, Yinmeng Zhu, Xiao Wang, Yaogan Luo, Yu Xu, Xu Lin, Yi Arial Zeng, Ruixin Liu, Jiqiu Wang","doi":"10.1111/1753-0407.70090","DOIUrl":null,"url":null,"abstract":"<div>\n \n \n <section>\n \n <h3> Aim</h3>\n \n <p>Circulating Gremlin 2 (Grem2) has recently been linked to human obesity, but its role in type 2 diabetes (T2D) remains unclear. This study aims to explore the association of circulating Grem2 with β-cell function.</p>\n </section>\n \n <section>\n \n <h3> Methods</h3>\n \n <p>A post hoc analysis was conducted using data from three clinical trials, in which all participants underwent the oral glucose tolerance test (OGTT). Circulating Grem2 levels were measured at 0, 1, and 2 h during the OGTT. In Trial 1, Grem2 levels were compared between participants with T2D (<i>n</i> = 59) and without T2D (<i>n</i> = 119). We further examined changes in Grem2 levels in response to oral antidiabetic drugs in participants with T2D in Trial 2 (<i>n</i> = 67) and calorie restriction in participants with prediabetes in Trial 3 (<i>n</i> = 231). The relationship between Grem2 levels and β-cell function was analyzed across all trials.</p>\n </section>\n \n <section>\n \n <h3> Results</h3>\n \n <p>Fasting and 1-h Grem2 levels were lower in participants with T2D compared with those without T2D (728 ± 25 vs. 649 ± 31 pg/mL, <i>p</i> = 0.020; 631 ± 26 vs. 537 ± 31 pg/mL, <i>p</i> = 0.007). Fasting Grem2 levels were restored after antidiabetic treatment (550 ± 12 vs. 575 ± 12 pg/mL, <i>p</i> = 0.019), and 1-h Grem2 levels increased following calorie restriction (1118 ± 89 vs. 1144 ± 90 vs. 1253 ± 89 pg/mL, <i>p</i> for trend = 0.002). The 1-h Grem2 levels were positively associated with β-cell function assessed by the oral disposition index and HOMA-β.</p>\n </section>\n \n <section>\n \n <h3> Conclusion</h3>\n \n <p>Reduced circulating Grem2 levels are associated with impaired β-cell function in T2D, and could be restored through antidiabetic interventions.</p>\n \n <p><b>Trial Registration:</b> ClinicalTrials.gov: NCT01959984, NCT01758471, NCT03856762</p>\n </section>\n </div>","PeriodicalId":189,"journal":{"name":"Journal of Diabetes","volume":"17 4","pages":""},"PeriodicalIF":3.7000,"publicationDate":"2025-04-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/1753-0407.70090","citationCount":"0","resultStr":"{\"title\":\"Association Between Circulating Gremlin 2 and β-Cell Function Among Participants With Prediabetes and Type 2 Diabetes\",\"authors\":\"Mengshan Ni, Yanru Chen, Weiqiong Gu, Yifei Zhang, Min Xu, Yanyun Gu, Yufei Chen, Yinmeng Zhu, Xiao Wang, Yaogan Luo, Yu Xu, Xu Lin, Yi Arial Zeng, Ruixin Liu, Jiqiu Wang\",\"doi\":\"10.1111/1753-0407.70090\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div>\\n \\n \\n <section>\\n \\n <h3> Aim</h3>\\n \\n <p>Circulating Gremlin 2 (Grem2) has recently been linked to human obesity, but its role in type 2 diabetes (T2D) remains unclear. This study aims to explore the association of circulating Grem2 with β-cell function.</p>\\n </section>\\n \\n <section>\\n \\n <h3> Methods</h3>\\n \\n <p>A post hoc analysis was conducted using data from three clinical trials, in which all participants underwent the oral glucose tolerance test (OGTT). Circulating Grem2 levels were measured at 0, 1, and 2 h during the OGTT. In Trial 1, Grem2 levels were compared between participants with T2D (<i>n</i> = 59) and without T2D (<i>n</i> = 119). We further examined changes in Grem2 levels in response to oral antidiabetic drugs in participants with T2D in Trial 2 (<i>n</i> = 67) and calorie restriction in participants with prediabetes in Trial 3 (<i>n</i> = 231). The relationship between Grem2 levels and β-cell function was analyzed across all trials.</p>\\n </section>\\n \\n <section>\\n \\n <h3> Results</h3>\\n \\n <p>Fasting and 1-h Grem2 levels were lower in participants with T2D compared with those without T2D (728 ± 25 vs. 649 ± 31 pg/mL, <i>p</i> = 0.020; 631 ± 26 vs. 537 ± 31 pg/mL, <i>p</i> = 0.007). Fasting Grem2 levels were restored after antidiabetic treatment (550 ± 12 vs. 575 ± 12 pg/mL, <i>p</i> = 0.019), and 1-h Grem2 levels increased following calorie restriction (1118 ± 89 vs. 1144 ± 90 vs. 1253 ± 89 pg/mL, <i>p</i> for trend = 0.002). The 1-h Grem2 levels were positively associated with β-cell function assessed by the oral disposition index and HOMA-β.</p>\\n </section>\\n \\n <section>\\n \\n <h3> Conclusion</h3>\\n \\n <p>Reduced circulating Grem2 levels are associated with impaired β-cell function in T2D, and could be restored through antidiabetic interventions.</p>\\n \\n <p><b>Trial Registration:</b> ClinicalTrials.gov: NCT01959984, NCT01758471, NCT03856762</p>\\n </section>\\n </div>\",\"PeriodicalId\":189,\"journal\":{\"name\":\"Journal of Diabetes\",\"volume\":\"17 4\",\"pages\":\"\"},\"PeriodicalIF\":3.7000,\"publicationDate\":\"2025-04-24\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://onlinelibrary.wiley.com/doi/epdf/10.1111/1753-0407.70090\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Journal of Diabetes\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://onlinelibrary.wiley.com/doi/10.1111/1753-0407.70090\",\"RegionNum\":2,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q2\",\"JCRName\":\"ENDOCRINOLOGY & METABOLISM\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of Diabetes","FirstCategoryId":"3","ListUrlMain":"https://onlinelibrary.wiley.com/doi/10.1111/1753-0407.70090","RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"ENDOCRINOLOGY & METABOLISM","Score":null,"Total":0}
引用次数: 0
摘要
循环Gremlin 2 （Grem2）最近与人类肥胖有关，但其在2型糖尿病（T2D）中的作用尚不清楚。本研究旨在探讨循环Grem2与β细胞功能的关系。方法采用三个临床试验的数据进行事后分析，所有参与者都进行了口服葡萄糖耐量试验（OGTT）。在OGTT期间的0、1和2小时测量循环Grem2水平。在试验1中，比较了T2D患者（n = 59）和非T2D患者（n = 119）之间的Grem2水平。我们进一步研究了试验2中T2D患者口服降糖药后Grem2水平的变化（n = 67）和试验3中糖尿病前期患者卡路里限制后Grem2水平的变化（n = 231）。在所有试验中分析Grem2水平与β细胞功能之间的关系。结果T2D患者的空腹和1 h Grem2水平低于无T2D患者(728±25∶649±31 pg/mL, p = 0.020；631±26比537±31 pg/mL， p = 0.007)。抗糖尿病治疗后，空腹Grem2水平恢复（550±12比575±12 pg/mL， p = 0.019），卡路里限制后1小时Grem2水平升高（1118±89比1144±90比1253±89 pg/mL， p趋势= 0.002）。通过口腔处置指数和HOMA-β评估，1 h Grem2水平与β细胞功能呈正相关。结论t2dm患者外周血Grem2水平降低与β细胞功能受损有关，可通过抗糖尿病干预恢复。试验注册：ClinicalTrials.gov: NCT01959984, NCT01758471, NCT03856762
Association Between Circulating Gremlin 2 and β-Cell Function Among Participants With Prediabetes and Type 2 Diabetes
Aim
Circulating Gremlin 2 (Grem2) has recently been linked to human obesity, but its role in type 2 diabetes (T2D) remains unclear. This study aims to explore the association of circulating Grem2 with β-cell function.
Methods
A post hoc analysis was conducted using data from three clinical trials, in which all participants underwent the oral glucose tolerance test (OGTT). Circulating Grem2 levels were measured at 0, 1, and 2 h during the OGTT. In Trial 1, Grem2 levels were compared between participants with T2D (n = 59) and without T2D (n = 119). We further examined changes in Grem2 levels in response to oral antidiabetic drugs in participants with T2D in Trial 2 (n = 67) and calorie restriction in participants with prediabetes in Trial 3 (n = 231). The relationship between Grem2 levels and β-cell function was analyzed across all trials.
Results
Fasting and 1-h Grem2 levels were lower in participants with T2D compared with those without T2D (728 ± 25 vs. 649 ± 31 pg/mL, p = 0.020; 631 ± 26 vs. 537 ± 31 pg/mL, p = 0.007). Fasting Grem2 levels were restored after antidiabetic treatment (550 ± 12 vs. 575 ± 12 pg/mL, p = 0.019), and 1-h Grem2 levels increased following calorie restriction (1118 ± 89 vs. 1144 ± 90 vs. 1253 ± 89 pg/mL, p for trend = 0.002). The 1-h Grem2 levels were positively associated with β-cell function assessed by the oral disposition index and HOMA-β.
Conclusion
Reduced circulating Grem2 levels are associated with impaired β-cell function in T2D, and could be restored through antidiabetic interventions.
期刊介绍：
Journal of Diabetes (JDB) devotes itself to diabetes research, therapeutics, and education. It aims to involve researchers and practitioners in a dialogue between East and West via all aspects of epidemiology, etiology, pathogenesis, management, complications and prevention of diabetes, including the molecular, biochemical, and physiological aspects of diabetes. The Editorial team is international with a unique mix of Asian and Western participation.
The Editors welcome submissions in form of original research articles, images, novel case reports and correspondence, and will solicit reviews, point-counterpoint, commentaries, editorials, news highlights, and educational content.
求助内容：
应助结果提醒方式：
京公网安备 11010802042870号
