Nature Microbiology最新文献_第6页

IF 19.4 1区生物学

Nature Microbiology Pub Date : 2026-03-27 DOI: 10.1038/s41564-026-02308-4

Yen-Ping Hsueh

引用次数: 0

An emerging human eye disease is associated with aquatic virus zoonotic infection 一种新出现的人眼疾病与水生病毒人畜共患感染有关。

IF 19.4 1区生物学

Nature Microbiology Pub Date : 2026-03-26 DOI: 10.1038/s41564-026-02266-x

Shuang Liu, Die Hu, Tingting Xu, Jia Yin, Xinmiao Shan, Jitao Xia, Zhaoxi Wang, Ruidong Xu, Chong Wang, Danielle E. Anderson, Peipei Wu, Qianwen Bu, Xiuzhen Liu, Yingjie Liu, Wenjie Tan, Ting Wang, Can Zhao, Hai Zhu, Lin-Fa Wang, Lixin Xie, Xiaojing Pan, Qingli Zhang

{"title":"An emerging human eye disease is associated with aquatic virus zoonotic infection","authors":"Shuang Liu, Die Hu, Tingting Xu, Jia Yin, Xinmiao Shan, Jitao Xia, Zhaoxi Wang, Ruidong Xu, Chong Wang, Danielle E. Anderson, Peipei Wu, Qianwen Bu, Xiuzhen Liu, Yingjie Liu, Wenjie Tan, Ting Wang, Can Zhao, Hai Zhu, Lin-Fa Wang, Lixin Xie, Xiaojing Pan, Qingli Zhang","doi":"10.1038/s41564-026-02266-x","DOIUrl":"10.1038/s41564-026-02266-x","url":null,"abstract":"Climate change and human activities have increased the risk of virus spillover from wildlife, posing a threat to human health. A human ocular disease called persistent ocular hypertensive viral anterior uveitis (POH-VAU) has recently emerged; however, the cause is unclear. Here we report that POH-VAU is associated with covert mortality nodavirus (CMNV) of aquatic origin. CMNV is prevalent in farmed and wild aquatic animals worldwide. We confirmed CMNV infection in ocular tissues and seroconversion in 70 patients with POH-VAU. An exposure survey and analysis of logistic regression models revealed that CMNV exposure frequency, number of severe exposures and exposure severity were associated with an increased risk of POH-VAU. Epidemiological data indicate that frequent unprotected processing of aquatic animals and consumption of raw aquatic animals were commonly reported exposure events, collectively accounting for 71.4% of investigated cases. Challenge tests revealed that CMNV can cause elevated intraocular pressure and pathological damage to ocular tissues in mice and can infect mammalian cells in vitro. This study reveals that an aquatic animal virus is associated with an emerging human disease. Covert mortality nodavirus, a pathogen previously known to cause important losses in shrimp aquaculture, is identified as being a potential causative agent of an emerging and severe ocular disease in humans, specifically presenting as persistent ocular hypertensive viral anterior uveitis.","PeriodicalId":18992,"journal":{"name":"Nature Microbiology","volume":"11 4","pages":"892-906"},"PeriodicalIF":19.4,"publicationDate":"2026-03-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147518430","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A global-scale assessment of zoonotic virus diversity and spillover potential in urban-adapted mammal species. 城市适应哺乳动物物种中人畜共患病毒多样性和溢出潜力的全球范围评估。

IF 28.3 1区生物学

Nature Microbiology Pub Date : 2026-03-26 DOI: 10.1038/s41564-026-02311-9

Xuemin Wei,Hongfeng Li,Zheng Y X Huang,Shuo Li,Yuhao Wang,Jie Lan,Li Hu,Yang Li,Daniel J Becker,Fuwen Wei,Yifei Xu

{"title":"A global-scale assessment of zoonotic virus diversity and spillover potential in urban-adapted mammal species.","authors":"Xuemin Wei,Hongfeng Li,Zheng Y X Huang,Shuo Li,Yuhao Wang,Jie Lan,Li Hu,Yang Li,Daniel J Becker,Fuwen Wei,Yifei Xu","doi":"10.1038/s41564-026-02311-9","DOIUrl":"https://doi.org/10.1038/s41564-026-02311-9","url":null,"abstract":"The repeated emergence of pandemic viruses underscores the linkages between land-use change and wildlife disease, and urban-adapted wildlife are of special interest due to their close proximity to humans. However, viral diversity within urban-adapted species and their zoonotic potential remain largely unexplored. Here we compiled a dataset of documented records spanning from 1574 to 2023 on red foxes, raccoons, raccoon dogs, masked palm civets, European hedgehogs, European shrews, wild boars and their viruses, covering 116 countries. These urban-adapted mammals host 286 virus species spanning 24 orders and 38 families, 14 of which are potentially high risk for human infection. Raccoon dogs had increased viral positivity in urban habitats compared to raccoons, wild boars and red foxes. Many viruses in urban-adapted species were phylogenetically related to those found in humans, and our data suggest possible viral spillback. These results highlight zoonotic risks associated with urban-adapted species and suggest enhanced surveillance to mitigate future outbreaks.","PeriodicalId":18992,"journal":{"name":"Nature Microbiology","volume":"103 1","pages":""},"PeriodicalIF":28.3,"publicationDate":"2026-03-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147518431","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Severe fever with thrombocytopenia syndrome virus infection of the male reproductive tract induces pathology and inflammation 发热伴血小板减少综合征病毒感染男性生殖道引起病理和炎症

IF 28.3 1区生物学

Nature Microbiology Pub Date : 2026-03-25 DOI: 10.1038/s41564-026-02298-3

Yunfa Zhang, Lingyu Zhang, Huan Xu, Xiaohong Yin, Xiaojie Zheng, Ning Cui, Hongdi Lv, Xiaoai Zhang, Liqun Fang, Leike Zhang, Hongbo Chen, Wei Liu, Hao Li

{"title":"Severe fever with thrombocytopenia syndrome virus infection of the male reproductive tract induces pathology and inflammation","authors":"Yunfa Zhang, Lingyu Zhang, Huan Xu, Xiaohong Yin, Xiaojie Zheng, Ning Cui, Hongdi Lv, Xiaoai Zhang, Liqun Fang, Leike Zhang, Hongbo Chen, Wei Liu, Hao Li","doi":"10.1038/s41564-026-02298-3","DOIUrl":"https://doi.org/10.1038/s41564-026-02298-3","url":null,"abstract":"Severe fever with thrombocytopenia syndrome virus (SFTSV) is an emerging bunyavirus causing severe systemic infection with high mortality rates. Previously, SFTSV RNA was reported in the semen of infected patients, but whether SFTSV infects the male reproductive tract remains unclear. Here we demonstrate that SFTSV exhibits broad tropism for male reproductive organs in mice, resulting in low sperm count and local inflammation. SFTSV infects Leydig cells in the testis, triggering apoptosis, pyroptosis and inflammation, thereby disrupting testosterone production. Single-cell RNA sequencing identified infiltration of CCR2+ and SPP1+ macrophages expressing S100A4, a key driver of epididymal hyperinflammation and fibrosis. An S100A4 inhibitor reduced pathology and mortality in infected mice. Potential male-to-female sexual transmission risk was observed in mice. In infected patients, viral shedding in semen correlated with disease severity and spermatogenic dysfunction, with viral persistence lasting nearly 3 months after symptom onset. These findings suggest a potential risk of sexual transmission and adverse effects on male reproductive health.","PeriodicalId":18992,"journal":{"name":"Nature Microbiology","volume":"17 1","pages":""},"PeriodicalIF":28.3,"publicationDate":"2026-03-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147506130","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Identification of transporter-dependent capsular loci associated with the invasive potential of Escherichia coli 与大肠杆菌侵袭潜能相关的转运蛋白依赖性荚膜位点的鉴定

IF 28.3 1区生物学

Nature Microbiology Pub Date : 2026-03-25 DOI: 10.1038/s41564-026-02283-w

Rebecca A. Gladstone, Maiju Pesonen, Anna K. Pöntinen, Tommi Mäklin, Neil MacAlasdair, Harry Thorpe, Yan Shao, Sudaraka Mallawaarachchi, Sergio Arredondo-Alonso, Benjamin J. Parcell, Jake David Turnbull, Gerry Tonkin-hill, Pål J. Johnsen, Ørjan Samuelsen, Nicholas R. Thomson, Trevor Lawley, Jukka Corander

{"title":"Identification of transporter-dependent capsular loci associated with the invasive potential of Escherichia coli","authors":"Rebecca A. Gladstone, Maiju Pesonen, Anna K. Pöntinen, Tommi Mäklin, Neil MacAlasdair, Harry Thorpe, Yan Shao, Sudaraka Mallawaarachchi, Sergio Arredondo-Alonso, Benjamin J. Parcell, Jake David Turnbull, Gerry Tonkin-hill, Pål J. Johnsen, Ørjan Samuelsen, Nicholas R. Thomson, Trevor Lawley, Jukka Corander","doi":"10.1038/s41564-026-02283-w","DOIUrl":"https://doi.org/10.1038/s41564-026-02283-w","url":null,"abstract":"Bacterial polysaccharide capsules contribute to antigenic diversity and immune evasion. Escherichia coli infections, including those caused by extraintestinal pathogenic E. coli (ExPEC), cause substantial antimicrobial resistance-associated morbidity and mortality. However, much-needed genotypic methods for E. coli capsule typing to aid epidemiological analysis and therapeutic design are lacking. Here we describe the curation of an in silico typing database for group 2 and 3 ATP-binding cassette transporter-dependent capsule (K) loci from 18,185 kps-positive E. coli genomes from all continents and its application to carriage and ExPEC disease cohorts. Capsules K1, K5 and K2 were the most common types in European BSIs, and together with K100 and K52 they were responsible for 58% of multidrug resistance, with differing associations with invasiveness. Homologous recombination, insertion sequences and plasmids were associated with capsular gene exchange. These findings improve understanding of capsule epidemiology and evolution to inform future diagnostic and therapeutic strategies to combat ExPEC infections.","PeriodicalId":18992,"journal":{"name":"Nature Microbiology","volume":"19 1","pages":""},"PeriodicalIF":28.3,"publicationDate":"2026-03-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147506129","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Climate change propels antibiotic resistance from soils into hospitals 气候变化促使土壤中的抗生素耐药性进入医院。

IF 19.4 1区生物学

Nature Microbiology Pub Date : 2026-03-23 DOI: 10.1038/s41564-026-02284-9

Timothy M. Ghaly

引用次数: 0

Drought drives elevated antibiotic resistance across soils 干旱导致土壤中抗生素耐药性升高

IF 19.4 1区生物学

Nature Microbiology Pub Date : 2026-03-23 DOI: 10.1038/s41564-026-02274-x

Xiaoyu Shan, Karen Cao, Hannah Jeckel, Reinaldo E. Alcalde, Inês B. Trindade, Jarek V. Kwiecinski, Dianne K. Newman

{"title":"Drought drives elevated antibiotic resistance across soils","authors":"Xiaoyu Shan, Karen Cao, Hannah Jeckel, Reinaldo E. Alcalde, Inês B. Trindade, Jarek V. Kwiecinski, Dianne K. Newman","doi":"10.1038/s41564-026-02274-x","DOIUrl":"10.1038/s41564-026-02274-x","url":null,"abstract":"Antibiotic resistance is a growing threat to human health and is often attributed to excessive clinical usage that selects for resistance. Although many antibiotics are derived from soil microorganisms, how environmental changes to soil ecosystems might promote resistance is poorly understood. Here we establish drought as a driving force of antibiotic resistance in the soil, with potentially far-reaching public health consequences. Across various geographic regions and soil types, we consistently observe metagenomic signatures of enrichment for antibiotic producers under drought conditions. Experimentally, we demonstrate that drought-induced lowering of water content concentrates natural antibiotics, thereby intensifying selection against sensitive strains and favouring antibiotic-resistant bacteria. Using clinical surveillance data from 116 countries, we show that the average frequency of hospital antibiotic resistance is strongly correlated with the local aridity index, even after controlling for regional income differences. Together, our findings reveal an underrecognized link between climate factors and antibiotic resistance. Drought conditions in soil systems lead to elevated concentrations of natural antibiotics, as well as the enrichment of antibiotic-resistant microorganisms, highlighting a link between climate and the spread of antimicrobial resistance.","PeriodicalId":18992,"journal":{"name":"Nature Microbiology","volume":"11 4","pages":"867-876"},"PeriodicalIF":19.4,"publicationDate":"2026-03-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147496839","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Science diplomacy, research and global health 科学外交、研究和全球卫生。

IF 19.4 1区生物学

Nature Microbiology Pub Date : 2026-03-23 DOI: 10.1038/s41564-026-02296-5

Delfina Fernandes Hlashwayo

引用次数: 0

LRP8 is a functional receptor for yellow fever virus LRP8是黄热病病毒的功能性受体。

IF 19.4 1区生物学

Nature Microbiology Pub Date : 2026-03-19 DOI: 10.1038/s41564-026-02278-7

Miao Mei, Yang Yang, Zihan Zhang, Yue Yin, Jiali Tan, Chao Jiang, Yu Gao, Zhaoyang Wang, Donghong Wang, Yajing Li, Yingyi Cong, Zhiyuan Zhang, Yousong Peng, Wenjie Tan, Jiandong Li, Li Li, Hanxuan Wang, Ren Lang, Qiang He, Zihou Deng, Xiaojie Huang, Bin Luo, Chao Shan, Yonghong Zhang, Lin Mei, Gong Cheng, Xu Tan

{"title":"LRP8 is a functional receptor for yellow fever virus","authors":"Miao Mei, Yang Yang, Zihan Zhang, Yue Yin, Jiali Tan, Chao Jiang, Yu Gao, Zhaoyang Wang, Donghong Wang, Yajing Li, Yingyi Cong, Zhiyuan Zhang, Yousong Peng, Wenjie Tan, Jiandong Li, Li Li, Hanxuan Wang, Ren Lang, Qiang He, Zihou Deng, Xiaojie Huang, Bin Luo, Chao Shan, Yonghong Zhang, Lin Mei, Gong Cheng, Xu Tan","doi":"10.1038/s41564-026-02278-7","DOIUrl":"10.1038/s41564-026-02278-7","url":null,"abstract":"Yellow fever virus (YFV) is an arbovirus causing substantial human morbidity and mortality. The live-attenuated 17D strain serves as vaccine and is one of the most successful vaccines so far. Receptor usage between attenuated and pathogenic YFV strains remains unclear. Here we performed a barcoded, genome-wide human open-reading frame library screen and identified LRP8 (also named APOER2) as a receptor for YFV. We show that LRP8 expression increases YFV infection (17D and two clinical strains, BJ01 and Asibi) in cell lines by promoting entry. Adeno-associated virus-mediated expression of human LRP8 in mouse liver aggravates infection and pathology of the clinical strain BJ01. LRP8 knockdown decreases YFV infection in brain cells, primary human hepatocytes and mosquitoes. LRP8 directly interacts with YFV 17D particles via the viral envelope protein. A soluble LRP8 decoy protein can block YFV 17D and BJ01 infection. Our findings provide insights for understanding YFV entry, tropism and pathogenesis. The human LRP8 protein is a receptor for yellow fever viruses (YFVs). Knockdown of the mosquito orthologue reduces YFV infection in mosquitoes, whereas overexpression of human LRP8 aggravates YFV infection in mice. Purified LRP8 protein blocks YFV infection.","PeriodicalId":18992,"journal":{"name":"Nature Microbiology","volume":"11 4","pages":"1022-1036"},"PeriodicalIF":19.4,"publicationDate":"2026-03-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147483661","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Metagenomic surveillance of zoonotic yellow fever and spillover dynamics at a forest–urban interface 人畜共患黄热病的宏基因组监测和森林-城市界面的溢出动态。

IF 19.4 1区生物学

Nature Microbiology Pub Date : 2026-03-19 DOI: 10.1038/s41564-026-02305-7

引用次数: 0