Nature Microbiology最新文献_第6页

Microplastic research must consider microbes 微塑料研究必须考虑微生物

IF 20.5 1区生物学

Nature Microbiology Pub Date : 2025-03-05 DOI: 10.1038/s41564-025-01960-6

引用次数: 0

The sweet side of IL-22 IL-22的好处

IF 20.5 1区生物学

Nature Microbiology Pub Date : 2025-03-03 DOI: 10.1038/s41564-025-01945-5

Jochem H. Bernink

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Dietary fibre counters the oncogenic potential of colibactin-producing Escherichia coli in colorectal cancer 膳食纤维对抗结肠直肠癌中产生大肠杆菌素的大肠杆菌的致癌潜力

IF 20.5 1区生物学

Nature Microbiology Pub Date : 2025-03-03 DOI: 10.1038/s41564-025-01938-4

Bhupesh Kumar Thakur, Yann Malaise, Saurav Roy Choudhury, Anna Neustaeter, Williams Turpin, Catherine Streutker, Julia Copeland, Erin O. Y. Wong, William W. Navarre, David S. Guttman, Christian Jobin, Kenneth Croitoru, Alberto Martin

{"title":"Dietary fibre counters the oncogenic potential of colibactin-producing Escherichia coli in colorectal cancer","authors":"Bhupesh Kumar Thakur, Yann Malaise, Saurav Roy Choudhury, Anna Neustaeter, Williams Turpin, Catherine Streutker, Julia Copeland, Erin O. Y. Wong, William W. Navarre, David S. Guttman, Christian Jobin, Kenneth Croitoru, Alberto Martin","doi":"10.1038/s41564-025-01938-4","DOIUrl":"10.1038/s41564-025-01938-4","url":null,"abstract":"Diet, microbiome, inflammation and host genetics have been linked to colorectal cancer development; however, it is not clear whether and how these factors interact to promote carcinogenesis. Here we used Il10−/− mice colonized with bacteria previously associated with colorectal cancer: enterotoxigenic Bacteroides fragilis, Helicobacter hepaticus or colibactin-producing (polyketide synthase-positive (pks+)) Escherichia coli and fed either a low-carbohydrate (LC) diet deficient in soluble fibre, a high-fat and high-sugar diet, or a normal chow diet. Colonic polyposis was increased in mice colonized with pks+ E. coli and fed the LC diet. Mechanistically, mucosal inflammation was increased in the LC-diet-fed mice, leading to diminished colonic PPAR-γ signalling and increased luminal nitrate levels. This promoted both pks+ E. coli growth and colibactin-induced DNA damage. PPAR-γ agonists or supplementation with dietary soluble fibre in the form of inulin reverted inflammatory and polyposis phenotypes. The pks+ E. coli also induced more polyps in mismatch-repair-deficient mice by inducing a senescence-associated secretory phenotype. Moreover, oncogenic effects were further potentiated by inflammatory triggers in the mismatch-repair-deficient model. These data reveal that diet and host genetics influence the oncogenic potential of a common bacterium. Reduced dietary fibre together with mutations in the host mismatch repair machinery promote colon carcinogenesis by increasing inflammation, nitrate-fuelled growth of colibactin-producing Escherichia coli and colibactin-dependent genotoxic tissue damage.","PeriodicalId":18992,"journal":{"name":"Nature Microbiology","volume":"10 4","pages":"855-870"},"PeriodicalIF":20.5,"publicationDate":"2025-03-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143532410","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Climate change will amplify the impacts of harmful microorganisms in aquatic ecosystems 气候变化将放大有害微生物对水生生态系统的影响

IF 20.5 1区生物学

Nature Microbiology Pub Date : 2025-02-28 DOI: 10.1038/s41564-025-01948-2

Justin R. Seymour, Sandra L. McLellan

{"title":"Climate change will amplify the impacts of harmful microorganisms in aquatic ecosystems","authors":"Justin R. Seymour, Sandra L. McLellan","doi":"10.1038/s41564-025-01948-2","DOIUrl":"10.1038/s41564-025-01948-2","url":null,"abstract":"More than 70% of the human population lives within five kilometres of a natural water feature. These aquatic ecosystems are heavily used for resource provision and recreation, and represent the interface between human populations and aquatic microbiomes, which can sometimes negatively impact human health. Diverse species of endemic aquatic microorganisms, including toxic microalgae and pathogenic bacteria, can be harmful to humans. Aquatic ecosystems are also subject to intrusions of allochthonous pathogenic microorganisms through pollution and runoff. Notably, environmental processes that amplify the abundance and impact of harmful aquatic microorganisms are occurring with increasing frequency owing to climate change. For instance, increases in water temperature stimulate outbreaks of pathogenic and toxic species, whereas more intense precipitation events escalate microbial contamination from stormwater discharge. In this Perspective we discuss the influence of aquatic microbiomes on the health and economies of human populations and examine how climate change is increasing these impacts. Here the authors discuss the influence of aquatic microbiomes on the health and economies of human populations and examine how climate changes might impact these dynamics.","PeriodicalId":18992,"journal":{"name":"Nature Microbiology","volume":"10 3","pages":"615-626"},"PeriodicalIF":20.5,"publicationDate":"2025-02-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143518141","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Rethinking concepts of virulence with Neisseria gonorrhoeae 重新思考淋病奈瑟菌的毒力概念

IF 20.5 1区生物学

Nature Microbiology Pub Date : 2025-02-27 DOI: 10.1038/s41564-025-01946-4

Alison K. Criss

引用次数: 0

One-carbon fixation via the synthetic reductive glycine pathway exceeds yield of the Calvin cycle 通过合成还原甘氨酸途径进行的单碳固定超过了卡尔文循环的产率

IF 20.5 1区生物学

Nature Microbiology Pub Date : 2025-02-27 DOI: 10.1038/s41564-025-01941-9

Beau Dronsella, Enrico Orsi, Helena Schulz-Mirbach, Sara Benito-Vaquerizo, Suzan Yilmaz, Timo Glatter, Arren Bar-Even, Tobias J. Erb, Nico J. Claassens

引用次数: 0

Surpassing natural limits in one-carbon assimilation 单碳同化超过自然极限的

IF 20.5 1区生物学

Nature Microbiology Pub Date : 2025-02-27 DOI: 10.1038/s41564-025-01943-7

Arslan Sarwar, Eun Yeol Lee

引用次数: 0

CRISPRi-ART enables functional genomics of diverse bacteriophages using RNA-binding dCas13d crispr - art利用rna结合dCas13d实现多种噬菌体的功能基因组学

IF 20.5 1区生物学

Nature Microbiology Pub Date : 2025-02-26 DOI: 10.1038/s41564-025-01935-7

Benjamin A. Adler, Muntathar J. Al-Shimary, Jaymin R. Patel, Emily G. Armbruster, David Colognori, Emeric J. Charles, Kate V. Miller, Arushi Lahiri, Michael L. Cui, Agnès Oromí-Bosch, Angela Voelker, Marena Trinidad, Jina Lee, Sebastien Beurnier, Ron Boger, Jason Nomburg, Rodolphe Barrangou, Vivek K. Mutalik, Joseph S. Schoeniger, Joseph A. Pogliano, David F. Savage, Jennifer A. Doudna, Brady F. Cress

{"title":"CRISPRi-ART enables functional genomics of diverse bacteriophages using RNA-binding dCas13d","authors":"Benjamin A. Adler, Muntathar J. Al-Shimary, Jaymin R. Patel, Emily G. Armbruster, David Colognori, Emeric J. Charles, Kate V. Miller, Arushi Lahiri, Michael L. Cui, Agnès Oromí-Bosch, Angela Voelker, Marena Trinidad, Jina Lee, Sebastien Beurnier, Ron Boger, Jason Nomburg, Rodolphe Barrangou, Vivek K. Mutalik, Joseph S. Schoeniger, Joseph A. Pogliano, David F. Savage, Jennifer A. Doudna, Brady F. Cress","doi":"10.1038/s41564-025-01935-7","DOIUrl":"10.1038/s41564-025-01935-7","url":null,"abstract":"Bacteriophages constitute one of the largest reservoirs of genes of unknown function in the biosphere. Even in well-characterized phages, the functions of most genes remain unknown. Experimental approaches to study phage gene fitness and function at genome scale are lacking, partly because phages subvert many modern functional genomics tools. Here we leverage RNA-targeting dCas13d to selectively interfere with protein translation and to measure phage gene fitness at a transcriptome-wide scale. We find CRISPR Interference through Antisense RNA-Targeting (CRISPRi-ART) to be effective across phage phylogeny, from model ssRNA, ssDNA and dsDNA phages to nucleus-forming jumbo phages. Using CRISPRi-ART, we determine a conserved role of diverse rII homologues in subverting phage Lambda RexAB-mediated immunity to superinfection and identify genes critical for phage fitness. CRISPRi-ART establishes a broad-spectrum phage functional genomics platform, revealing more than 90 previously unknown genes important for phage fitness. Leveraging RNA-targeting dCas13d enables selective interference with phage protein translation and facilitates measurement of phage gene fitness at a transcriptome-wide scale.","PeriodicalId":18992,"journal":{"name":"Nature Microbiology","volume":"10 3","pages":"694-709"},"PeriodicalIF":20.5,"publicationDate":"2025-02-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.nature.com/articles/s41564-025-01935-7.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143495273","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Publisher Correction: Design and regulation of engineered bacteria for environmental release 出版者更正：环境释放工程细菌的设计和调节

IF 20.5 1区生物学

Nature Microbiology Pub Date : 2025-02-24 DOI: 10.1038/s41564-025-01956-2

Yonatan Chemla, Connor J. Sweeney, Christopher A. Wozniak, Christopher A. Voigt

引用次数: 0

Planning and describing a microbiome data analysis 规划和描述微生物组数据分析

IF 20.5 1区生物学

Nature Microbiology Pub Date : 2025-02-21 DOI: 10.1038/s41564-025-01944-6

Amy D. Willis, David S. Clausen

引用次数: 0