Nature Reviews Cardiology最新文献

Cardiovascular disease prevention in China: challenges and opportunities in the artificial intelligence-enabled digital health era. 中国心血管疾病预防：人工智能数字健康时代的挑战与机遇

IF 49.6 1区医学

Nature Reviews Cardiology Pub Date : 2025-10-16 DOI: 10.1038/s41569-025-01222-2

Dong Zhao,Yun Zhang,Jiguang Wang,Liu He,Yihua He,Changsheng Ma

引用次数: 0

Resolutions from the Women As One RISE 2025 conference for women in cardiology. 女性作为一个上升2025年会议的决议，妇女心脏病学。

IF 49.6 1区医学

Nature Reviews Cardiology Pub Date : 2025-10-14 DOI: 10.1038/s41569-025-01225-z

Roxana Mehran,Karoline Bowman,Valeria Raona,Maria Rubini Giménez,Liesl Zühlke

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AQUATIC findings sink antiplatelet therapy for patients with chronic coronary syndrome requiring oral anticoagulants. 水生研究结果表明抗血小板治疗对慢性冠状动脉综合征患者需要口服抗凝剂。

IF 49.6 1区医学

Nature Reviews Cardiology Pub Date : 2025-10-13 DOI: 10.1038/s41569-025-01224-0

William A E Parker,Robert F Storey

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LOX1 blockade does not modify atherosclerosis progression in patients with MI. LOX1阻断剂不能改变心肌梗死患者的动脉粥样硬化进展。

IF 49.6 1区医学

Nature Reviews Cardiology Pub Date : 2025-10-10 DOI: 10.1038/s41569-025-01226-y

Irene Fernández-Ruiz

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The global cardiovascular-liver-metabolic syndemic: epidemiology, trends and challenges. 全球心血管-肝脏-代谢综合征：流行病学、趋势和挑战。

IF 49.6 1区医学

Nature Reviews Cardiology Pub Date : 2025-10-06 DOI: 10.1038/s41569-025-01220-4

Nicholas W S Chew,Anurag Mehta,Rachel Goh,Jaycie Koh,Yiming Chen,Bryan Chong,Mark Y Chan,Muhammad Shahzeb Khan,Mark D Muthiah,Javed Butler,Arun J Sanyal,Laurence S Sperling

{"title":"The global cardiovascular-liver-metabolic syndemic: epidemiology, trends and challenges.","authors":"Nicholas W S Chew,Anurag Mehta,Rachel Goh,Jaycie Koh,Yiming Chen,Bryan Chong,Mark Y Chan,Muhammad Shahzeb Khan,Mark D Muthiah,Javed Butler,Arun J Sanyal,Laurence S Sperling","doi":"10.1038/s41569-025-01220-4","DOIUrl":"https://doi.org/10.1038/s41569-025-01220-4","url":null,"abstract":"The growing epidemics of metabolic-dysfunction-associated steatotic liver disease, type 2 diabetes mellitus, obesity and cardiovascular disease are inextricably linked. Cardiovascular-liver-metabolic (CLM) diseases coexist and interact to constitute a synergy of epidemics (a syndemic), with shared mechanisms and socioeconomic influences. The goal of this Review is to construct this complex public-health issue into a unified framework, using epidemiological data to illustrate the current burden of disease and the trends in the CLM syndemic and to make projections for the future. We also discuss the challenges of promoting CLM health and the need for shared solutions. The proposed micro-meso-macro framework integrates strategies to improve risk prediction and precision prevention and to disentangle the competing risks within the CLM construct (micro), while keeping communities at the heart of CLM health promotion by ensuring access to healthy foods, healthy environments and metabolic interventions (meso). In addition, we propose interventions to eliminate inequities in the social and commercial determinants of health, from communities to healthcare systems (macro). Thus, multisystem interventions could address the trajectories of the CLM disease epidemics simultaneously.","PeriodicalId":18976,"journal":{"name":"Nature Reviews Cardiology","volume":"33 1","pages":""},"PeriodicalIF":49.6,"publicationDate":"2025-10-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145235756","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Takotsubo syndrome: pathophysiological insights and innovations in patient care. Takotsubo综合征：病理生理学的见解和患者护理的创新。

IF 49.6 1区医学

Nature Reviews Cardiology Pub Date : 2025-10-02 DOI: 10.1038/s41569-025-01211-5

Elmir Omerovic,Björn Redfors

{"title":"Takotsubo syndrome: pathophysiological insights and innovations in patient care.","authors":"Elmir Omerovic,Björn Redfors","doi":"10.1038/s41569-025-01211-5","DOIUrl":"https://doi.org/10.1038/s41569-025-01211-5","url":null,"abstract":"Takotsubo syndrome, also known as broken heart syndrome, was first described in Japan in the 1990s and presents as acute heart failure caused by transient contractile dysfunction that mimics acute coronary syndrome but is not caused by acute coronary obstruction. Takotsubo syndrome accounts for as much as 2-3% of suspected coronary syndromes and is considerably more common in women than in men. In this Review, we discuss the historical background and clinical features of Takotsubo syndrome and our evolving understanding of its pathophysiology. The hallmark feature of Takotsubo syndrome is transient left ventricular dysfunction linked to emotional or physical stressors. Despite advances in our understanding of the clinical presentation and possible pathophysiological mechanisms of Takotsubo syndrome, this condition continues to challenge our fundamental understanding of human anatomy and physiology, particularly regarding how acute emotional and physical stressors can trigger such profound cardiovascular dysfunction. Although the definitive mechanisms remain elusive, current hypotheses largely centre on catecholamine surges and sympathetic nervous system hyperactivation. Diagnostic criteria have been developed by the Mayo Clinic and European Society of Cardiology working groups but, in the absence of randomized controlled clinical trials, no specific treatments for Takotsubo syndrome are available. In this Review, we highlight the complex pathophysiology of Takotsubo syndrome, with an emphasis on the interplay between emotional stress and cardiac health, and call for the development of evidence-based management protocols.","PeriodicalId":18976,"journal":{"name":"Nature Reviews Cardiology","volume":"1 1","pages":""},"PeriodicalIF":49.6,"publicationDate":"2025-10-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145209087","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Multimodal, device-based therapeutic targeting of the cardiovascular autonomic nervous system. 多模式、基于装置的心血管自主神经系统靶向治疗。

IF 49.6 1区医学

Nature Reviews Cardiology Pub Date : 2025-10-01 DOI: 10.1038/s41569-025-01212-4

Julian F R Paton,Tymoteusz Żera,Rajanikanth Vadigepalli,Neil Herring,David J Paterson

{"title":"Multimodal, device-based therapeutic targeting of the cardiovascular autonomic nervous system.","authors":"Julian F R Paton,Tymoteusz Żera,Rajanikanth Vadigepalli,Neil Herring,David J Paterson","doi":"10.1038/s41569-025-01212-4","DOIUrl":"https://doi.org/10.1038/s41569-025-01212-4","url":null,"abstract":"The miniaturization of implantable sensors and actuators, combined with advances in interactive modelling and high-resolution imaging, is propelling the use of medical devices for counteracting impaired neural control of the cardiovascular system. In this Review, we discuss the current effectiveness of this technology for modulating autonomic activity in numerous cardiovascular conditions, including high blood pressure, heart failure and cardiac arrhythmias. We advocate for smarter closed-loop bionic devices fitted with feedback from multiple sensors to allow adaptive, state-dependent control, and discuss how the adoption of artificial intelligence technology would facilitate auto-personalization to meet the needs of patients. We also describe how transcriptomics of autonomic circuits can guide device-based approaches. Finally, the use of stem cell therapies to target sympathetic circuits more precisely will help to optimize the therapeutic effects of autonomic modulation for the treatment of arrhythmia. For bioelectronic medicine to achieve clinical utility in neurocardiology, these innovations must demonstrate improved efficacy beyond that offered by contemporary interventions.","PeriodicalId":18976,"journal":{"name":"Nature Reviews Cardiology","volume":"76 1","pages":""},"PeriodicalIF":49.6,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145203620","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Resistin-like molecule-γ promotes arrhythmia and cell death after MI. 抵抗素样分子-γ促进心肌梗死后心律失常和细胞死亡。

IF 49.6 1区医学

Nature Reviews Cardiology Pub Date : 2025-09-23 DOI: 10.1038/s41569-025-01221-3

Karina Huynh

引用次数: 0

Influenza vaccination reduces hospitalization and improves heart failure outcomes 流感疫苗可减少住院治疗并改善心力衰竭的结果。

IF 44.2 1区医学

Nature Reviews Cardiology Pub Date : 2025-09-18 DOI: 10.1038/s41569-025-01219-x

Gregory B. Lim

引用次数: 0

Sleep and circadian rhythms in cardiovascular resilience: mechanisms, implications, and a Roadmap for research and interventions. 心血管恢复力中的睡眠和昼夜节律：机制、含义和研究和干预的路线图。

IF 49.6 1区医学

Nature Reviews Cardiology Pub Date : 2025-09-18 DOI: 10.1038/s41569-025-01188-1

Brooke Aggarwal,Yunling Gao,Alfonso Alfini,Ali Azarbarzin,Ron C Anafi,Kelly Glazer Baron,Victoria L Bautch,Nicole Bowles,Josiane L Broussard,Marishka Brown,Philip Cheng,Stephanie H Cook,Rene Cortese,Fabian-Xosé Fernandez,Zorina Galis,Dayna A Johnson,Sanja Jelic,Jonathan O Lipton,Pamela L Lutsey,Qing Miao,Jose M Ordovas,Aric A Prather,Filip K Swirski,Esra Tasali,Ivan Vargas,Michael A Grandner,Donald Lloyd-Jones

{"title":"Sleep and circadian rhythms in cardiovascular resilience: mechanisms, implications, and a Roadmap for research and interventions.","authors":"Brooke Aggarwal,Yunling Gao,Alfonso Alfini,Ali Azarbarzin,Ron C Anafi,Kelly Glazer Baron,Victoria L Bautch,Nicole Bowles,Josiane L Broussard,Marishka Brown,Philip Cheng,Stephanie H Cook,Rene Cortese,Fabian-Xosé Fernandez,Zorina Galis,Dayna A Johnson,Sanja Jelic,Jonathan O Lipton,Pamela L Lutsey,Qing Miao,Jose M Ordovas,Aric A Prather,Filip K Swirski,Esra Tasali,Ivan Vargas,Michael A Grandner,Donald Lloyd-Jones","doi":"10.1038/s41569-025-01188-1","DOIUrl":"https://doi.org/10.1038/s41569-025-01188-1","url":null,"abstract":"The interaction between sleep, circadian rhythms and cardiovascular resilience is a crucial yet underexplored research area with important public health implications. Disruptions in sleep and circadian rhythms exacerbate hypertension, diabetes mellitus and obesity, conditions that are increasingly prevalent globally and increase the risk of cardiovascular disease. A National Heart, Lung, and Blood Institute workshop examined these connections, as well as the emerging concept of cardiovascular resilience as a dynamic and multifaceted concept spanning molecular, cellular and systemic levels across an individual's lifespan. The workshop emphasized the need to expand the focus from solely understanding whether and how sleep and circadian rhythm disturbances contribute to disease, to also exploring how healthy sleep and aligned circadian rhythms can increase cardiovascular resilience. To develop a Roadmap towards this goal, workshop participants identified key knowledge gaps and research opportunities, including the need to integrate biological, behavioural, environmental and societal factors in sleep and circadian health with cardiovascular research to identify therapeutic targets. Proposed interventions encompass behavioural therapies, chronotherapy, lifestyle changes, organizational policies and public health initiatives aimed at improving sleep and circadian health for better cardiovascular outcomes. Future cross-disciplinary research and translation of discoveries into public health strategies and clinical practices could improve cardiovascular resilience across the lifespan in all populations.","PeriodicalId":18976,"journal":{"name":"Nature Reviews Cardiology","volume":"63 1","pages":""},"PeriodicalIF":49.6,"publicationDate":"2025-09-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145083526","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0