Nature Reviews Cardiology最新文献

CD8⁺ T cells in atherosclerosis and coronary artery disease. CD8+ T细胞在动脉粥样硬化和冠状动脉疾病中的作用。

IF 44.2 1区医学

Nature Reviews Cardiology Pub Date : 2026-05-05 DOI: 10.1038/s41569-026-01295-7

Ishita Tandon, Mohamed Yosri, Hadeer Soliman, Alaa M Khalifa, Klaus Ley, Hossam A Abdelsamed

{"title":"CD8+ T cells in atherosclerosis and coronary artery disease.","authors":"Ishita Tandon, Mohamed Yosri, Hadeer Soliman, Alaa M Khalifa, Klaus Ley, Hossam A Abdelsamed","doi":"10.1038/s41569-026-01295-7","DOIUrl":"https://doi.org/10.1038/s41569-026-01295-7","url":null,"abstract":"Cardiovascular diseases remain a global health challenge, with >600 million cases reported annually. Atherosclerosis is a common pathology that underlies various cardiovascular diseases, such as myocardial infarction and stroke. Both the innate and adaptive immune systems have crucial roles in the progression of atherosclerosis. CD8+ T cells are the most clonally expanded adaptive immune cells in human atherosclerotic plaques, but whether these cells are pro-atherogenic or atheroprotective during the different stages of atherosclerosis development and progression is unclear. In this Review, we summarize the latest knowledge on the role of CD8+ T cells in atherosclerosis. We discuss the phenotypic, functional and transcriptional features of CD8+ T cells in atherosclerosis and shed light on their involvement in comorbidities to understand the landscape of CD8+ T cells during the progression of atherosclerosis. We also highlight key research gaps and questions that need to be addressed to improve our understanding of the functions of CD8+ T cells in atherosclerosis. Targeting CD8+ T cells could provide potential therapeutic avenues to prevent and mitigate adverse cardiovascular events in patients with atherosclerosis and coronary heart disease.","PeriodicalId":18976,"journal":{"name":"Nature Reviews Cardiology","volume":" ","pages":""},"PeriodicalIF":44.2,"publicationDate":"2026-05-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147840316","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Digital screening and decision-support tools in equitable preventive cardiology. 公平预防心脏病学中的数字筛查和决策支持工具。

IF 44.2 1区医学

Nature Reviews Cardiology Pub Date : 2026-04-30 DOI: 10.1038/s41569-026-01299-3

Dang Nguyen, Tuan Vinh

引用次数: 0

Base editing and silencing of PCSK9 shows clinical promise in humans. PCSK9的碱基编辑和沉默在人类中显示出临床前景。

IF 49.6 1区医学

Nature Reviews Cardiology Pub Date : 2026-04-27 DOI: 10.1038/s41569-026-01297-5

Archna Bajaj,Daniel J Rader

引用次数: 0

Local calcium dynamics and signalling in cardiomyocytes. 心肌细胞局部钙动力学和信号传导。

IF 49.6 1区医学

Nature Reviews Cardiology Pub Date : 2026-04-22 DOI: 10.1038/s41569-026-01286-8

Jean-Pierre Benitah,Laetitia Pereira,Romain Perrier,Jean-Jacques Mercadier,Jessica Sabourin,Ana María Gómez

{"title":"Local calcium dynamics and signalling in cardiomyocytes.","authors":"Jean-Pierre Benitah,Laetitia Pereira,Romain Perrier,Jean-Jacques Mercadier,Jessica Sabourin,Ana María Gómez","doi":"10.1038/s41569-026-01286-8","DOIUrl":"https://doi.org/10.1038/s41569-026-01286-8","url":null,"abstract":"Calcium (Ca²⁺) signalling is essential for cardiomyocyte function, regulating excitation-contraction coupling and excitation-transcription coupling, and contributing to mitochondrial energy production (excitation-bioenergetics coupling). In this Review, we explore the role of Ca²⁺ microdomains, which compartmentalize Ca²⁺ signalling to ensure efficient cardiac function. We first describe the organization of these microdomains, followed by their functional importance, pathological alterations in heart failure and potential therapeutic strategies targeting key Ca²⁺-signalling mechanisms. The dyad, a crucial excitation-contraction coupling microdomain, brings L-type Ca²⁺ channels and ryanodine receptor Ca²⁺-release channels (RYR2) into close proximity, facilitating Ca²⁺-induced Ca²⁺ release for cardiomyocyte contraction. In heart failure, dyadic remodelling and altered Ca²⁺ handling contribute to cardiac contractile dysfunction and arrhythmogenesis. Emerging research shows that dyads are dynamic, rapidly adapting to modulators such as β-adrenergic signalling, offering new therapeutic targets. Under stress conditions, dyadic proteins can translocate to the nucleus to regulate gene expression. In addition to excitation-contraction coupling, which operates on a beat-to-beat basis, Ca²⁺ has additional roles in cardiomyocytes. Nuclear Ca²⁺ regulates the expression of genes related to hypertrophy, including those encoding Ca²⁺ channels and transporters. Disruptions in these microdomains drive pathological remodelling in heart failure and arrhythmias. Understanding Ca²⁺ microdomains is crucial for developing targeted interventions to restore cardiac function while minimizing pro-arrhythmic risks.","PeriodicalId":18976,"journal":{"name":"Nature Reviews Cardiology","volume":"23 1","pages":""},"PeriodicalIF":49.6,"publicationDate":"2026-04-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147733967","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Stenting for post-thrombotic syndrome. 血栓形成后综合征的支架植入。

IF 44.2 1区医学

Nature Reviews Cardiology Pub Date : 2026-04-21 DOI: 10.1038/s41569-026-01298-4

Gregory B Lim

引用次数: 0

Beyond GLP1: modulating multiple nutrient-stimulated hormone pathways to reduce cardiovascular risk. 超越GLP1：调节多种营养刺激激素通路以降低心血管风险。

IF 49.6 1区医学

Nature Reviews Cardiology Pub Date : 2026-04-20 DOI: 10.1038/s41569-026-01296-6

Yu Mi Kang,Josephine Harrington,Vanita R Aroda,Darren K McGuire

引用次数: 0

Soft robotic devices for cardiovascular medicine. 用于心血管医学的软体机器人装置。

IF 49.6 1区医学

Nature Reviews Cardiology Pub Date : 2026-04-17 DOI: 10.1038/s41569-026-01287-7

Xing-Yu Ji,Jia-Qi Zhu,Ke Wu,Liu Wang,Tian-Yuan Xiong,Li Zhang,Mao Chen

{"title":"Soft robotic devices for cardiovascular medicine.","authors":"Xing-Yu Ji,Jia-Qi Zhu,Ke Wu,Liu Wang,Tian-Yuan Xiong,Li Zhang,Mao Chen","doi":"10.1038/s41569-026-01287-7","DOIUrl":"https://doi.org/10.1038/s41569-026-01287-7","url":null,"abstract":"Conventional, rigid simulators and therapeutic devices for cardiovascular disease have several fundamental limitations, such as poor biomimetic fidelity, substantial surgical invasiveness and mismatch at the tissue-device interface. Soft robotic devices, with tissue-like materials, structures and functions, are emerging as promising alternatives. In this Review, by matching clinical demands to technological breakthroughs, we identify three emerging complementary frontiers in which soft robotic devices are redefining cardiovascular medicine - soft robotic simulators, such as in vitro ventricular simulators and in vivo assistive simulators; soft robotic interventional instruments, such as percutaneous instruments, endovascular continuum instruments and untethered mini-scale robots; and soft robotic implants for vascular disease, arrhythmia and heart failure. We describe the unique advantages of soft robotic devices as well as their applicable scope and technical implementation. Finally, we highlight promising technological opportunities for next-generation soft cardiac devices, evaluate the clinical maturity of existing devices and propose a translational roadmap for the coming decade. With this Review, we aim to foster further integration of soft robotics into cardiovascular medicine by identifying device solutions with translational potential to address unmet clinical needs.","PeriodicalId":18976,"journal":{"name":"Nature Reviews Cardiology","volume":"14 1","pages":""},"PeriodicalIF":49.6,"publicationDate":"2026-04-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147702128","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Fibrosis-targeted, immunosuppressive dendritic cells mitigate cardiac adverse remodelling. 纤维化靶向，免疫抑制树突状细胞减轻心脏不良重构。

IF 49.6 1区医学

Nature Reviews Cardiology Pub Date : 2026-04-16 DOI: 10.1038/s41569-026-01294-8

Irene Fernández-Ruiz

引用次数: 0

Medics for Rare Disease: advocating for rare disease training. 罕见病医生：倡导罕见病培训。

IF 49.6 1区医学

Nature Reviews Cardiology Pub Date : 2026-04-15 DOI: 10.1038/s41569-026-01291-x

Emma Huskinson,Helen Maginnis,Lucy McKay

引用次数: 0

Caution needed with microaxial flow pumps during high-risk PCI. 高危PCI手术中使用微轴流泵需谨慎。