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Nature Reviews Cardiology最新文献

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Predictive cardio-omics: translating single-cell multiomics into tools for personalized medicine
IF 49.6 1区 医学
Nature Reviews Cardiology Pub Date : 2025-02-03 DOI: 10.1038/s41569-025-01132-3
Kami Pekayvaz, Matthias Heinig, Konstantin Stark
{"title":"Predictive cardio-omics: translating single-cell multiomics into tools for personalized medicine","authors":"Kami Pekayvaz, Matthias Heinig, Konstantin Stark","doi":"10.1038/s41569-025-01132-3","DOIUrl":"https://doi.org/10.1038/s41569-025-01132-3","url":null,"abstract":"In this Clinical Outlook, we describe available multiomic studies in cardiovascular medicine, discuss the advantages and potential of multiomic techniques for clinical translation in cardiology, and highlight three promising aspects: the generation of unprecedented cellular atlases, the identification of composite diagnostic and prognostic biomarkers derived from integrative multiomic signatures, and the isolation of potential therapeutic targets from unbiased comprehensive datasets and analyses.","PeriodicalId":18976,"journal":{"name":"Nature Reviews Cardiology","volume":"8 1","pages":""},"PeriodicalIF":49.6,"publicationDate":"2025-02-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143076932","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Obesity alters cholesterol homeostasis in regulatory T cells of visceral adipose tissue
IF 49.6 1区 医学
Nature Reviews Cardiology Pub Date : 2025-01-28 DOI: 10.1038/s41569-025-01129-y
Irene Fernández-Ruiz
{"title":"Obesity alters cholesterol homeostasis in regulatory T cells of visceral adipose tissue","authors":"Irene Fernández-Ruiz","doi":"10.1038/s41569-025-01129-y","DOIUrl":"https://doi.org/10.1038/s41569-025-01129-y","url":null,"abstract":"A new study shows how obesity can disrupt a cholesterol metabolism in a particular subset of metabolically protective regulatory T cells in visceral adipose tissue.","PeriodicalId":18976,"journal":{"name":"Nature Reviews Cardiology","volume":"7 1","pages":""},"PeriodicalIF":49.6,"publicationDate":"2025-01-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143050044","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The molecular structure of LDL has finally been elucidated
IF 49.6 1区 医学
Nature Reviews Cardiology Pub Date : 2025-01-28 DOI: 10.1038/s41569-025-01128-z
Gilles C. Lambert, Simon G. Pfisterer
{"title":"The molecular structure of LDL has finally been elucidated","authors":"Gilles C. Lambert, Simon G. Pfisterer","doi":"10.1038/s41569-025-01128-z","DOIUrl":"https://doi.org/10.1038/s41569-025-01128-z","url":null,"abstract":"Two studies published in Nature report the structure of apolipoprotein B100 on LDL using high-resolution, artificial intelligence-assisted cryo-electron microscopy and uncover its precise molecular interfaces with the LDL receptor. Dimers of LDL particles connected by a pair of receptors are also visualized for the first time. These studies provide key structural insights into the molecular defects linked to familial hypercholesterolaemia and open exciting avenues for translational research and drug development.","PeriodicalId":18976,"journal":{"name":"Nature Reviews Cardiology","volume":"47 1","pages":""},"PeriodicalIF":49.6,"publicationDate":"2025-01-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143050046","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Colchicine in acute coronary syndromes: the present and the possible future
IF 49.6 1区 医学
Nature Reviews Cardiology Pub Date : 2025-01-28 DOI: 10.1038/s41569-025-01124-3
Massimo Imazio, Federico Ballacci, Federica Giordano
{"title":"Colchicine in acute coronary syndromes: the present and the possible future","authors":"Massimo Imazio, Federico Ballacci, Federica Giordano","doi":"10.1038/s41569-025-01124-3","DOIUrl":"https://doi.org/10.1038/s41569-025-01124-3","url":null,"abstract":"Inflammation is a new therapeutic target for the prevention of cardiovascular disease. Colchicine is a potential cheap option to target inflammation and prevent atherosclerotic plaque destabilization. We discuss major clinical trials and guidelines on the use of colchicine in patients with coronary syndromes, especially acute coronary syndromes, in whom results have been conflicting.","PeriodicalId":18976,"journal":{"name":"Nature Reviews Cardiology","volume":"40 1","pages":""},"PeriodicalIF":49.6,"publicationDate":"2025-01-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143050043","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Anthracycline-induced cardiomyopathy: risk prediction, prevention and treatment
IF 49.6 1区 医学
Nature Reviews Cardiology Pub Date : 2025-01-28 DOI: 10.1038/s41569-025-01126-1
Iacopo Fabiani, Michela Chianca, Carlo Maria Cipolla, Daniela Maria Cardinale
{"title":"Anthracycline-induced cardiomyopathy: risk prediction, prevention and treatment","authors":"Iacopo Fabiani, Michela Chianca, Carlo Maria Cipolla, Daniela Maria Cardinale","doi":"10.1038/s41569-025-01126-1","DOIUrl":"https://doi.org/10.1038/s41569-025-01126-1","url":null,"abstract":"<p>Anthracyclines are the cornerstone of treatment for many malignancies. However, anthracycline cardiotoxicity is a considerable concern given that it can compromise the clinical effectiveness of the treatment and patient survival despite early discontinuation of therapy or dose reduction. Patients with cancer receiving anthracycline treatment can have a reduction in their quality of life and likelihood of survival due to cardiotoxicity, irrespective of their oncological prognosis. Increasing knowledge about anthracycline cardiotoxicity has enabled the identification of patients who are candidates for anthracycline regimens and those who might develop anthracycline-induced cardiomyopathy. Anthracycline cardiotoxicity is a unique and evolving phenomenon that begins with myocardial cell damage, progresses to reduced left ventricular ejection fraction, and culminates in symptomatic heart failure if it is not promptly detected and treated. Early risk stratification can be guided by imaging or biomarkers. In this Review, we present a comprehensive and clinically useful approach to cardiomyopathy related to anthracycline therapy, encompassing its epidemiology, definition, mechanisms, novel classifications, risk factors and patient risk stratification, diagnostic approaches (including imaging and biomarkers), treatment guidelines algorithms, and the role of new cardioprotective drugs that are used for the treatment of heart failure.</p>","PeriodicalId":18976,"journal":{"name":"Nature Reviews Cardiology","volume":"22 1","pages":""},"PeriodicalIF":49.6,"publicationDate":"2025-01-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143050047","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The relationship between cannabis and cardiovascular disease: clearing the haze 大麻与心血管疾病的关系：清雾
IF 49.6 1区 医学
Nature Reviews Cardiology Pub Date : 2025-01-23 DOI: 10.1038/s41569-025-01121-6
Mark Chandy, Nerea Jimenez-Tellez, Joseph C. Wu
{"title":"The relationship between cannabis and cardiovascular disease: clearing the haze","authors":"Mark Chandy, Nerea Jimenez-Tellez, Joseph C. Wu","doi":"10.1038/s41569-025-01121-6","DOIUrl":"https://doi.org/10.1038/s41569-025-01121-6","url":null,"abstract":"<p>Cannabis has been consumed for centuries, but global regulatory changes over the past three decades have increased the availability and consumption of cannabis. Cannabinoids are touted to have therapeutic potential for many diseases and could be a replacement for opioids for analgesia and sedation. However, cannabinoids can cause substantial adverse cardiovascular events that would mitigate any potential benefit. The endocannabinoid system regulates mood, satiety and memory, and modulates the cardiovascular system. The link between cannabinoids and cardiovascular disease, which used to be limited to evidence from preclinical studies, case reports and case series, is now evident in epidemiological studies. Cannabinoids adversely affect the cardiovascular system, causing myocardial infarction, cerebrovascular accidents, arrhythmia and heart failure. The effects of novel cannabinoids are unknown, and synthetic cannabinoids have the potential to cause even more substantial harm than traditional cannabinoids. Therefore, with the increasing availability and use of cannabis, the acute and chronic effects of this drug are becoming apparent.</p>","PeriodicalId":18976,"journal":{"name":"Nature Reviews Cardiology","volume":"74 1","pages":""},"PeriodicalIF":49.6,"publicationDate":"2025-01-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143019989","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Traction force microscopy of cardiomyocytes 心肌细胞的牵引力显微镜观察
IF 49.6 1区 医学
Nature Reviews Cardiology Pub Date : 2025-01-21 DOI: 10.1038/s41569-025-01123-4
Maia Lyall
{"title":"Traction force microscopy of cardiomyocytes","authors":"Maia Lyall","doi":"10.1038/s41569-025-01123-4","DOIUrl":"https://doi.org/10.1038/s41569-025-01123-4","url":null,"abstract":"In this Tools of the Trade article, Lyall discusses the use of traction force microscopy to assess the contractile function of individual cardiomyocytes.","PeriodicalId":18976,"journal":{"name":"Nature Reviews Cardiology","volume":"46 1","pages":""},"PeriodicalIF":49.6,"publicationDate":"2025-01-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142990885","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
AI-driven evolution of precision population cardiovascular health in cities 人工智能驱动的城市精准人群心血管健康进化
IF 49.6 1区 医学
Nature Reviews Cardiology Pub Date : 2025-01-21 DOI: 10.1038/s41569-025-01125-2
Ann Aerts, Michelle A. Williams
{"title":"AI-driven evolution of precision population cardiovascular health in cities","authors":"Ann Aerts, Michelle A. Williams","doi":"10.1038/s41569-025-01125-2","DOIUrl":"https://doi.org/10.1038/s41569-025-01125-2","url":null,"abstract":"New research shows how the social determinants of cardiovascular health vary locally within cities. Artificial intelligence makes it possible to quantify the relative importance of these social determinants at a hyper-local level, which can inform interventions. To realize these opportunities, new partnership models are needed that pay special attention to data quality and governance.","PeriodicalId":18976,"journal":{"name":"Nature Reviews Cardiology","volume":"32 1","pages":""},"PeriodicalIF":49.6,"publicationDate":"2025-01-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142992068","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Interventions for adult congenital heart disease 成人先天性心脏病的干预措施
IF 49.6 1区 医学
Nature Reviews Cardiology Pub Date : 2025-01-20 DOI: 10.1038/s41569-025-01118-1
Pedro Cepas-Guillén, Eduardo Flores-Umanzor, Eric Horlick, Jamil Aboulhosn, Lee Benson, Xavier Freixa, Christine Houde, Josep Rodés-Cabau
{"title":"Interventions for adult congenital heart disease","authors":"Pedro Cepas-Guillén, Eduardo Flores-Umanzor, Eric Horlick, Jamil Aboulhosn, Lee Benson, Xavier Freixa, Christine Houde, Josep Rodés-Cabau","doi":"10.1038/s41569-025-01118-1","DOIUrl":"https://doi.org/10.1038/s41569-025-01118-1","url":null,"abstract":"<p>Advances in imaging diagnostics, surgical techniques and transcatheter interventions for paediatric patients with severe congenital heart disease (CHD) have substantially reduced mortality, thereby extending the lifespan of these individuals and increasing the number of adults with complex CHD. Transcatheter interventions have emerged as an alternative to traditional open-heart surgery to mitigate congenital defects. The evolution of techniques, the introduction of new devices and the growing experience of operators have enabled the treatment of patients with progressively more complex conditions. The general cardiology community might be less aware of contemporary interventions for adult CHD, their clinical indications and associated outcomes than interventional cardiologists and congenital heart specialists. In this Review, we provide a comprehensive evaluation of the available transcatheter interventions for adult patients with CHD.</p>","PeriodicalId":18976,"journal":{"name":"Nature Reviews Cardiology","volume":"5 1","pages":""},"PeriodicalIF":49.6,"publicationDate":"2025-01-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142990887","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Mind the gap: sex-related differences in cardiovascular disease 注意差距：心血管疾病中与性别有关的差异
IF 49.6 1区 医学
Nature Reviews Cardiology Pub Date : 2025-01-14 DOI: 10.1038/s41569-025-01120-7
Anju Loveridge
{"title":"Mind the gap: sex-related differences in cardiovascular disease","authors":"Anju Loveridge","doi":"10.1038/s41569-025-01120-7","DOIUrl":"https://doi.org/10.1038/s41569-025-01120-7","url":null,"abstract":"Anju Loveridge discusses the Framingham Heart Study report that described the link between diabetes mellitus and cardiovascular disease as well as sex-related differences in cardiovascular disease.","PeriodicalId":18976,"journal":{"name":"Nature Reviews Cardiology","volume":"28 1","pages":""},"PeriodicalIF":49.6,"publicationDate":"2025-01-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142981339","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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