Nature Reviews Cardiology最新文献

{"title":"Atheroprotection mediated by hepatic PPARα is linked to its anti-inflammatory, but not lipid-lowering, properties","authors":"Karina Huynh","doi":"10.1038/s41569-025-01182-7","DOIUrl":"https://doi.org/10.1038/s41569-025-01182-7","url":null,"abstract":"A new study in science Translational Medicine demonstrates that the atheroprotective effects of PPARα agonists are associated with their anti-inflammatory properties rather than their lipid-lowering activity, highlighting the importance of targeting inflammation in managing the residual risk of cardiovascular disease","PeriodicalId":18976,"journal":{"name":"Nature Reviews Cardiology","volume":"20 1","pages":""},"PeriodicalIF":49.6,"publicationDate":"2025-06-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144268539","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Leadless and extravascular cardiac resynchronization therapy: the future for CRT?","authors":"Steven Niederer, Henry Chubb, Kenneth C. Bilchick, Christopher Aldo Rinaldi","doi":"10.1038/s41569-025-01178-3","DOIUrl":"https://doi.org/10.1038/s41569-025-01178-3","url":null,"abstract":"Cardiac resynchronization therapy is used to treat dyssynchronous heart failure. Lead-related complications and anatomical constraints can limit pacing lead placement, but leadless systems are now becoming available. These new systems overcome lead-related issues, offering a new option for patients with complex disease (such as congenital heart disease) by eliminating intravascular hardware.","PeriodicalId":18976,"journal":{"name":"Nature Reviews Cardiology","volume":"2 1","pages":""},"PeriodicalIF":49.6,"publicationDate":"2025-06-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144237229","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cardiovascular involvement in glycogen storage diseases","authors":"Tomàs Pinós, Richard M. Cubbon, Alfredo Santalla, Carmen Fiuza-Luces, Alejandro Santos-Lozano, Miguel A. Martín, Joaquín Arenas, Joachim Nielsen, Niels Ørtenblad, Alejandro Lucia","doi":"10.1038/s41569-025-01171-w","DOIUrl":"https://doi.org/10.1038/s41569-025-01171-w","url":null,"abstract":"<p>Glycogen storage diseases are rare conditions affecting both sexes that are caused by inherited deficiencies of enzymes involved either in glycogen synthesis or breakdown, or in glycolysis. The liver and skeletal muscle are usually the most affected tissues. However, because glycogen has an important role in cardiac development and function, several glycogen storage diseases are associated, at least indirectly, with cardiac disorders, some of which have severe consequences from the first months of life. Early identification of these conditions is, therefore, an important issue, and implementation of strategies to prevent fatal outcomes due to cardiovascular disease is vital. In this Review, we discuss the pathophysiological mechanisms and the preclinical, clinical and epidemiological evidence for cardiovascular involvement in various glycogen storage diseases. We also describe interventions that can help preserve heart function, including changes in nutrition and exercise, as well as the few available molecular therapies to address the underlying metabolic anomalies.</p>","PeriodicalId":18976,"journal":{"name":"Nature Reviews Cardiology","volume":"17 1","pages":""},"PeriodicalIF":49.6,"publicationDate":"2025-06-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144218799","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Think Aorta: aortic dissection awareness and perspectives from the patient","authors":"Gareth Owens","doi":"10.1038/s41569-025-01177-4","DOIUrl":"https://doi.org/10.1038/s41569-025-01177-4","url":null,"abstract":"Aortic dissection has long been considered a rare, unpreventable and inevitably fatal disease. However, recent advances now prove otherwise. The patient-led Think Aorta campaign is challenging old thinking, improving diagnosis and advocating for better care, such as family screening. Patient advocacy and recent international guidelines classifying the aorta as an organ are catalysts for further improvements in patient care.","PeriodicalId":18976,"journal":{"name":"Nature Reviews Cardiology","volume":"29 1","pages":""},"PeriodicalIF":49.6,"publicationDate":"2025-06-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144201638","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Networking effectively with cardiovascular societies: strategies for meaningful engagement and career advancement","authors":"Purvi Parwani, F. Aaysha Cader","doi":"10.1038/s41569-025-01174-7","DOIUrl":"https://doi.org/10.1038/s41569-025-01174-7","url":null,"abstract":"Effective engagement with cardiovascular societies enhances professional development, academic growth and leadership opportunities. We describe practical strategies for cardiovascular professionals to connect with their peers, seek mentorship, advance professionally and contribute as active members of the cardiovascular society, to develop an impactful career and advance the field of cardiac medicine.","PeriodicalId":18976,"journal":{"name":"Nature Reviews Cardiology","volume":"10 1","pages":""},"PeriodicalIF":49.6,"publicationDate":"2025-05-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144164849","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Reply to ‘Neuroendocrine regulatory effects of sex hormones on salt sensitivity of blood pressure’","authors":"Sepiso K. Masenga, Annet Kirabo","doi":"10.1038/s41569-025-01176-5","DOIUrl":"https://doi.org/10.1038/s41569-025-01176-5","url":null,"abstract":"<p>We appreciate the opportunity to reply to the points raised by M. Zhou et al. (Neuroendocrine regulatory effects of sex hormones on salt sensitivity of blood pressure. <i>Nat. Rev. Cardiol</i><i>.</i> https://doi.org/10.1338/10.1038/s41569-025-01175-6 2025)¹ on our Review (Masenga, S. K. et al. Salt sensitivity of blood pressure: mechanisms and sex-specific differences. <i>Nat. Rev. Cardiol</i><i>.</i> https://doi.org/10.1038/s41569-025-01135-0 2025)².</p><p>Transient receptor potential vanilloid 4 (TRPV4) is a Ca²⁺-permeable channel expressed in endothelium and neurons. Evidence indicates that endothelial TRPV4 activation causes vasodilatation by increasing intracellular Ca²⁺ concentration, which triggers nitric oxide (NO), prostacyclin and endothelium-derived hyperpolarizing factor pathways³. However, under certain conditions (such as strong agonism or in specific vascular beds), TRPV4 activation can paradoxically evoke vasoconstriction³. Therefore, reports of a ‘dual’ role are context dependent: mild TRPV4 activation produces net vasodilatation, whereas very high TRPV4 activity or TRPV4 activation in specific vessels can cause vasoconstriction. Importantly, TRPV4 activation (with 4α-phorbol 12,13-didecanoate (4α-PDD)) has been shown to acutely lower blood pressure in rats, and a high-salt diet augments this hypotensive effect⁴. In the latter study, rats receiving a high-salt diet expressed more TRPV4 and had a larger drop in blood pressure in response to TRPV4 agonism, suggesting that TRPV4 provides a compensatory vasodilatory response to salt loading⁴.</p>","PeriodicalId":18976,"journal":{"name":"Nature Reviews Cardiology","volume":"35 1","pages":""},"PeriodicalIF":49.6,"publicationDate":"2025-05-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144153483","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Neuroendocrine regulatory effects of sex hormones on salt sensitivity of blood pressure","authors":"Mi Zhou, Bing-hua Wang, Yu-chan Wang, Wen-jun Zhang, Li-xue Yin","doi":"10.1038/s41569-025-01175-6","DOIUrl":"https://doi.org/10.1038/s41569-025-01175-6","url":null,"abstract":"<p>We read with great interest the Review by S. K. Masenga et al. (Salt sensitivity of blood pressure: mechanisms and sex-specific differences. <i>Nat. Rev. Cardiol.</i> https://doi.org/10.1038/s41569-025-01135-0 2025)¹. The authors summarized the interactions between sex hormones, the renin–angiotensin–aldosterone system and the epithelial Na⁺ channel in the development of salt-sensitive hypertension¹. Oestrogen is protective against salt-sensitive hypertension in women (especially premenopausal women) through its activation of the mitogen-activated protein kinase signalling pathway and downstream protein phosphorylation to increase nitric oxide production in endothelial cells, while inhibiting oxidative stress and inflammation by reducing the synthesis and activity of NADPH oxidases and suppressing nuclear factor of activated T cells (NFAT) transcription factors¹. The Review further mentioned the potential role of sex-specific differences in renin–angiotensin–aldosterone system activation and expression of the epithelial Na⁺ channel in salt-sensitive hypertension¹. We believe that some other crucial information should be taken into account to fully understand the complex mechanisms regulating the salt sensitivity of blood pressure based on sex hormones.</p><p>First, the Review mentioned that nitric oxide production in female and male rats was regulated by transient receptor potential vanilloid 4 (TRPV4) and transient receptor potential canonical 3 (TRPC3), respectively¹. Although some studies have shown that activation of TRPV4-dependent Ca²⁺ influx has an important role in endothelium-dependent vasodilatation, other studies have found that TRPV4 mediates vasoconstriction and high-salt-induced hypertension^2,3. In addition, TRPV4 is also involved in the perception of variation in blood osmotic pressure by osmotic pressure receptor neurons in the supraoptic nucleus and paraventricular nucleus of the hypothalamus and the regulation of antidiuretic hormone (also known as vasopressin)⁴. <i>Trpv4</i>-knockout mice have impaired osmoregulation under hypertonic stress, leading to elevated systemic osmotic pressure⁵. Therefore, further research on the effects of TRPV4 on the vascular endothelium and blood pressure and the underlying mechanisms is essential.</p>","PeriodicalId":18976,"journal":{"name":"Nature Reviews Cardiology","volume":"43 1","pages":""},"PeriodicalIF":49.6,"publicationDate":"2025-05-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144153577","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Gene therapy for cardiac arrhythmias","authors":"Sahej Bains, John R. Giudicessi, Katja E. Odening, Michael J. Ackerman","doi":"10.1038/s41569-025-01168-5","DOIUrl":"https://doi.org/10.1038/s41569-025-01168-5","url":null,"abstract":"<p>Cardiovascular diseases are the leading cause of death globally, with cardiac arrhythmias contributing substantially to this burden. Gene therapy, which directly targets the underlying disease pathobiology, offers an appealing treatment strategy for cardiac arrhythmias owing to its potential as a one-time, curative solution. Over the past two decades, substantial efforts have been made to develop new gene therapy approaches that overcome the limitations of conventional treatments. In this Review, we describe the rationale for gene therapy to treat cardiac arrhythmias; discuss advantages and disadvantages of gene silencing, gene replacement, gene suppression-and-replacement and gene editing technologies; summarize vector modalities and delivery approaches used in the field; present examples of gene therapy strategies used for atrial and ventricular arrhythmias; and highlight the current challenges and limitations in the gene therapy field.</p>","PeriodicalId":18976,"journal":{"name":"Nature Reviews Cardiology","volume":"55 1","pages":""},"PeriodicalIF":49.6,"publicationDate":"2025-05-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144130677","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"LDL-cholesterol lowering with obicetrapib","authors":"Gregory B. Lim","doi":"10.1038/s41569-025-01173-8","DOIUrl":"https://doi.org/10.1038/s41569-025-01173-8","url":null,"abstract":"In the TANDEM and BROADWAY clinical trials, treatment with the CETP inhibitor obicetrapib in addition to background lipid-lowering therapy significantly reduced plasma LDL-cholesterol levels.","PeriodicalId":18976,"journal":{"name":"Nature Reviews Cardiology","volume":"19 1","pages":""},"PeriodicalIF":49.6,"publicationDate":"2025-05-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144113340","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"From data to impact: why conference presentation skills are essential for cardiovascular research dissemination","authors":"Marta Catarina Almeida, Ricardo Fontes-Carvalho","doi":"10.1038/s41569-025-01170-x","DOIUrl":"https://doi.org/10.1038/s41569-025-01170-x","url":null,"abstract":"Conference presentation skills are a crucial, yet often overlooked, element in the dissemination of cardiovascular research. In an era of information overload and digital communication, the ability to clearly and engagingly present scientific data is essential, to ensure that the findings are understood, shared and implemented into clinical practice.","PeriodicalId":18976,"journal":{"name":"Nature Reviews Cardiology","volume":"9 1","pages":""},"PeriodicalIF":49.6,"publicationDate":"2025-05-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144096868","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}