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Redefining respiratory sinus arrhythmia as respiratory heart rate variability: an international Expert Recommendation for terminological clarity. 将呼吸性窦性心律失常重新定义为呼吸性心率变异性：术语清晰度的国际专家建议。
IF 49.6 1区 医学
Nature Reviews Cardiology Pub Date : 2025-05-06 DOI: 10.1038/s41569-025-01160-z
Clément Menuet,Alona Ben-Tal,Ambre Linossier,Andrew M Allen,Benedito H Machado,Davi J A Moraes,David G S Farmer,David J Paterson,David Mendelowitz,Edward G Lakatta,Edwin W Taylor,Gareth L Ackland,Irving H Zucker,James P Fisher,James S Schwaber,Julia Shanks,Julian F R Paton,Julie Buron,K Michael Spyer,Kalyanam Shivkumar,Mathias Dutschmann,Michael J Joyner,Neil Herring,Paul Grossman,Robin M McAllen,Rohit Ramchandra,Song T Yao,Thomas Ritz,Alexander V Gourine
{"title":"Redefining respiratory sinus arrhythmia as respiratory heart rate variability: an international Expert Recommendation for terminological clarity.","authors":"Clément Menuet,Alona Ben-Tal,Ambre Linossier,Andrew M Allen,Benedito H Machado,Davi J A Moraes,David G S Farmer,David J Paterson,David Mendelowitz,Edward G Lakatta,Edwin W Taylor,Gareth L Ackland,Irving H Zucker,James P Fisher,James S Schwaber,Julia Shanks,Julian F R Paton,Julie Buron,K Michael Spyer,Kalyanam Shivkumar,Mathias Dutschmann,Michael J Joyner,Neil Herring,Paul Grossman,Robin M McAllen,Rohit Ramchandra,Song T Yao,Thomas Ritz,Alexander V Gourine","doi":"10.1038/s41569-025-01160-z","DOIUrl":"https://doi.org/10.1038/s41569-025-01160-z","url":null,"abstract":"The variation of heart rate in phase with breathing, known as 'respiratory sinus arrhythmia' (RSA), is a physiological phenomenon present in all air-breathing vertebrates. RSA arises from the interaction of several physiological mechanisms but is primarily mediated by rhythmic changes in cardiac parasympathetic (vagal) activity, increasing heart rate during inspiration and decreasing heart rate during expiration. RSA amplitude is an indicator of autonomic and cardiac health; RSA is diminished or absent in common pathological conditions such as chronic heart failure and hypertension. In this Expert Recommendation, we argue that the term 'RSA', although historically important, is semantically inaccurate and carries misleading pathological connotations, contributing to misunderstanding and misinterpretation of the origin and the physiological importance of the phenomenon. We propose replacing 'RSA' with the term 'respiratory heart rate variability' (RespHRV), which avoids pathological connotations and emphasizes the specific respiratory contribution to heart rate variability. We clarify that RespHRV encompasses respiratory-related heart rate variations in both the low-frequency and high-frequency bands traditionally defined in heart rate variability analysis, and that its amplitude should not be misconstrued as a measure of vagal tone. Adopting the proposed term 'RespHRV' is expected to unify understanding and stimulate further experimental and clinical research into the physiological mechanisms and functional importance of this phenomenon.","PeriodicalId":18976,"journal":{"name":"Nature Reviews Cardiology","volume":"51 1","pages":""},"PeriodicalIF":49.6,"publicationDate":"2025-05-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143915152","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Decongestion in heart failure: medical and device therapies 心力衰竭的去充血：医疗和器械疗法
IF 49.6 1区 医学
Nature Reviews Cardiology Pub Date : 2025-04-28 DOI: 10.1038/s41569-025-01152-z
Zachary L. Cox, Kevin Damman, Jeffrey M. Testani
{"title":"Decongestion in heart failure: medical and device therapies","authors":"Zachary L. Cox, Kevin Damman, Jeffrey M. Testani","doi":"10.1038/s41569-025-01152-z","DOIUrl":"https://doi.org/10.1038/s41569-025-01152-z","url":null,"abstract":"<p>Heart failure is a leading cause of hospitalization worldwide, and congestion is the predominant cause of heart failure symptoms and hospitalization. The primary therapy used to treat and prevent congestion has historically been loop diuretics. However, many patients are discharged from hospital with residual congestion, which is associated with persistent heart failure symptoms, adverse outcomes and hospital readmission. Multiple medical strategies and devices have been and are being investigated with the aim of improving decongestion and subsequent heart failure outcomes. Numerous questions exist about the design of clinical trials to test emerging medical and device therapies, including the magnitude of benefit on congestive, kidney and post-discharge outcomes relative to conventional decongestion practices, and how best to implement novel therapies. In this Review, we discuss emerging medical and device strategies targeting congestion in patients with heart failure.</p>","PeriodicalId":18976,"journal":{"name":"Nature Reviews Cardiology","volume":"32 1","pages":""},"PeriodicalIF":49.6,"publicationDate":"2025-04-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143880706","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Sotatercept as add-on therapy for advanced PAH 索替赛普作为晚期多环芳烃的附加治疗
IF 49.6 1区 医学
Nature Reviews Cardiology Pub Date : 2025-04-22 DOI: 10.1038/s41569-025-01161-y
Xiulin Köhler
{"title":"Sotatercept as add-on therapy for advanced PAH","authors":"Xiulin Köhler","doi":"10.1038/s41569-025-01161-y","DOIUrl":"https://doi.org/10.1038/s41569-025-01161-y","url":null,"abstract":"Sotatercept, an activin-signalling inhibitor, is a promising add-on treatment for patients with advanced pulmonary arterial hypertension and a high risk of death, according to data from the ZENITH trial.","PeriodicalId":18976,"journal":{"name":"Nature Reviews Cardiology","volume":"108 1","pages":""},"PeriodicalIF":49.6,"publicationDate":"2025-04-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143857762","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Pulsed field ablation non-inferior to cryoablation for paroxysmal AF 脉冲场消融治疗阵发性房颤优于冷冻消融
IF 49.6 1区 医学
Nature Reviews Cardiology Pub Date : 2025-04-16 DOI: 10.1038/s41569-025-01159-6
Irene Fernández-Ruiz
{"title":"Pulsed field ablation non-inferior to cryoablation for paroxysmal AF","authors":"Irene Fernández-Ruiz","doi":"10.1038/s41569-025-01159-6","DOIUrl":"https://doi.org/10.1038/s41569-025-01159-6","url":null,"abstract":"In patients with symptomatic paroxysmal atrial fibrillation, pulsed field ablation is non-inferior to cryoballoon ablation for preventing the recurrence of atrial tachyarrhythmia, according to findings from the SINGLE SHOT CHAMPION trial.","PeriodicalId":18976,"journal":{"name":"Nature Reviews Cardiology","volume":"7 1","pages":""},"PeriodicalIF":49.6,"publicationDate":"2025-04-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143836689","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Expanding cardiovascular indications for semaglutide: results from the SOUL and STRIDE trials 扩大塞马鲁肽的心血管适应症：SOUL 和 STRIDE 试验的结果
IF 49.6 1区 医学
Nature Reviews Cardiology Pub Date : 2025-04-14 DOI: 10.1038/s41569-025-01158-7
Karina Huynh
{"title":"Expanding cardiovascular indications for semaglutide: results from the SOUL and STRIDE trials","authors":"Karina Huynh","doi":"10.1038/s41569-025-01158-7","DOIUrl":"https://doi.org/10.1038/s41569-025-01158-7","url":null,"abstract":"Two clinical trials presented at the ACC.25 describe the expanding indications for the glucagon-like peptide 1 receptor agonist semaglutide in patients with type 2 diabetes mellitus.","PeriodicalId":18976,"journal":{"name":"Nature Reviews Cardiology","volume":"49 1","pages":""},"PeriodicalIF":49.6,"publicationDate":"2025-04-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143831797","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Post-translational acylation of proteins in cardiac hypertrophy 心肌肥厚中蛋白质的翻译后酰化
IF 49.6 1区 医学
Nature Reviews Cardiology Pub Date : 2025-04-14 DOI: 10.1038/s41569-025-01150-1
Ying-Qi Liu, Qin Yang, Guo-Wei He
{"title":"Post-translational acylation of proteins in cardiac hypertrophy","authors":"Ying-Qi Liu, Qin Yang, Guo-Wei He","doi":"10.1038/s41569-025-01150-1","DOIUrl":"https://doi.org/10.1038/s41569-025-01150-1","url":null,"abstract":"<p>Acylations are post-translational modifications in which functional groups are attached to amino acids on proteins. Most acylations (acetylation, butyrylation, crotonylation, lactylation, malonylation, propionylation and succinylation) involve lysine but cysteine (palmitoylation) and glycine (myristoylation) residues can also be altered. Acylations have important roles in physiological and pathophysiological processes, including cardiac hypertrophy and related cardiovascular diseases. These post-translational modifications influence chromatin architecture, transcriptional regulation and metabolic pathways, thereby affecting cardiomyocyte function and pathology. The dynamic interaction between these acylations and their regulatory enzymes, such as histone acetyltransferases, histone deacetylases and sirtuins, underscores the complexity of cellular homeostasis and pathological processes. Emerging evidence highlights the therapeutic potential of targeting acylations to modulate enzyme activity and metabolite levels, offering promising avenues for novel treatments. In this Review, we explore the diverse mechanisms through which acylations contribute to cardiac hypertrophy, highlighting the complexity and potential therapeutic targets in this regulatory network.</p>","PeriodicalId":18976,"journal":{"name":"Nature Reviews Cardiology","volume":"183 1","pages":""},"PeriodicalIF":49.6,"publicationDate":"2025-04-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143827315","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
No effect of cerebral embolic protection devices on stroke risk after TAVI 脑栓塞保护装置对TAVI术后卒中风险无影响
IF 49.6 1区 医学
Nature Reviews Cardiology Pub Date : 2025-04-10 DOI: 10.1038/s41569-025-01156-9
Irene Fernández-Ruiz
{"title":"No effect of cerebral embolic protection devices on stroke risk after TAVI","authors":"Irene Fernández-Ruiz","doi":"10.1038/s41569-025-01156-9","DOIUrl":"https://doi.org/10.1038/s41569-025-01156-9","url":null,"abstract":"Findings from the BHF PROTECT-TAVI trial indicate that the routine use of cerebral embolic protection devices during transcatheter aortic valve implantation does not decrease the incidence of stroke within 72 h after the intervention.","PeriodicalId":18976,"journal":{"name":"Nature Reviews Cardiology","volume":"60 1","pages":""},"PeriodicalIF":49.6,"publicationDate":"2025-04-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143819332","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Development of a miniature, bioresorbable, light-activated pacemaker 微型，生物可吸收，光激活起搏器的开发
IF 49.6 1区 医学
Nature Reviews Cardiology Pub Date : 2025-04-10 DOI: 10.1038/s41569-025-01157-8
Gregory B. Lim
{"title":"Development of a miniature, bioresorbable, light-activated pacemaker","authors":"Gregory B. Lim","doi":"10.1038/s41569-025-01157-8","DOIUrl":"https://doi.org/10.1038/s41569-025-01157-8","url":null,"abstract":"Researchers have engineered a millimetre-scale, bioresorbable, optoelectronic system that can be minimally invasively implanted into the heart and wirelessly controlled by a light source on the surface of the skin to provide temporary cardiac pacing.","PeriodicalId":18976,"journal":{"name":"Nature Reviews Cardiology","volume":"12 1","pages":""},"PeriodicalIF":49.6,"publicationDate":"2025-04-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143819246","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Apolipoprotein B100 revisited 载脂蛋白B100重测
IF 49.6 1区 医学
Nature Reviews Cardiology Pub Date : 2025-04-10 DOI: 10.1038/s41569-025-01155-w
Mia S. Manojlovic, Melaku Taye Amogne
{"title":"Apolipoprotein B100 revisited","authors":"Mia S. Manojlovic, Melaku Taye Amogne","doi":"10.1038/s41569-025-01155-w","DOIUrl":"https://doi.org/10.1038/s41569-025-01155-w","url":null,"abstract":"Mia Manojlovic and Melaku Taye Amogne highlight the 1986 study that unravelled the primary structure of apolipoprotein B100 and laid a foundation for subsequent studies on the role of this apolipoprotein.","PeriodicalId":18976,"journal":{"name":"Nature Reviews Cardiology","volume":"4 1","pages":""},"PeriodicalIF":49.6,"publicationDate":"2025-04-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143813465","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Primordial prevention of cardiovascular disease 从根本上预防心血管疾病
IF 49.6 1区 医学
Nature Reviews Cardiology Pub Date : 2025-04-08 DOI: 10.1038/s41569-025-01153-y
Hooi Min Lim
{"title":"Primordial prevention of cardiovascular disease","authors":"Hooi Min Lim","doi":"10.1038/s41569-025-01153-y","DOIUrl":"https://doi.org/10.1038/s41569-025-01153-y","url":null,"abstract":"Hooi Min Lim describes how the Bogalusa Heart Study emphasized the importance of primordial prevention of cardiovascular disease and profoundly influenced subsequent cardiovascular research on children and adolescents.","PeriodicalId":18976,"journal":{"name":"Nature Reviews Cardiology","volume":"34 1","pages":""},"PeriodicalIF":49.6,"publicationDate":"2025-04-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143797662","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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