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Targeting macrophage–fibroblast interactions in the failing heart 针对衰竭心脏中巨噬细胞与成纤维细胞的相互作用
IF 49.6 1区 医学
Nature Reviews Cardiology Pub Date : 2024-12-16 DOI: 10.1038/s41569-024-01112-z
Nikolaos G. Frangogiannis
{"title":"Targeting macrophage–fibroblast interactions in the failing heart","authors":"Nikolaos G. Frangogiannis","doi":"10.1038/s41569-024-01112-z","DOIUrl":"https://doi.org/10.1038/s41569-024-01112-z","url":null,"abstract":"Macrophage–fibroblast interactions have a central role in cardiac fibrosis. In response to left ventricular pressure overload, CCR2+ cardiac macrophages acquire a fibrogenic phenotype, secreting IL-1β and promoting the activation of a FAP+ POSTN+ fibroblast subpopulation through the transcription factor MEOX1. Macrophage-derived fibroblast-activating cytokines (such as IL-1β), growth factors and matricellular proteins contribute to the pathogenesis of heart failure.","PeriodicalId":18976,"journal":{"name":"Nature Reviews Cardiology","volume":"12 1","pages":""},"PeriodicalIF":49.6,"publicationDate":"2024-12-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142831959","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Left atrial appendage closure after ablation: the best OPTION for patients with AF?
IF 49.6 1区 医学
Nature Reviews Cardiology Pub Date : 2024-12-11 DOI: 10.1038/s41569-024-01113-y
Karina Huynh
{"title":"Left atrial appendage closure after ablation: the best OPTION for patients with AF?","authors":"Karina Huynh","doi":"10.1038/s41569-024-01113-y","DOIUrl":"https://doi.org/10.1038/s41569-024-01113-y","url":null,"abstract":"Two studies presented at AHA 2024 Scientific Sessions describe the efficacy and safety of left atrial appendage closure after catheter ablation for atrial fibrillation and the 5-year outcomes of the largest randomized left atrial appendage closure trial to date comparing the safety and efficacy of two devices.","PeriodicalId":18976,"journal":{"name":"Nature Reviews Cardiology","volume":"62 1","pages":""},"PeriodicalIF":49.6,"publicationDate":"2024-12-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142809728","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Pro-arrhythmic potential of proton-pump inhibitors
IF 49.6 1区 医学
Nature Reviews Cardiology Pub Date : 2024-12-09 DOI: 10.1038/s41569-024-01107-w
Pietro Enea Lazzerini, Riccardo Accioli, Pier Leopoldo Capecchi, Maurizio Acampa
{"title":"Pro-arrhythmic potential of proton-pump inhibitors","authors":"Pietro Enea Lazzerini, Riccardo Accioli, Pier Leopoldo Capecchi, Maurizio Acampa","doi":"10.1038/s41569-024-01107-w","DOIUrl":"https://doi.org/10.1038/s41569-024-01107-w","url":null,"abstract":"Population studies have reported that proton-pump inhibitors (PPIs) increase cardiovascular mortality, at least in part owing to an increased propensity for life-threatening arrhythmias, but these findings have largely been ignored. We propose a series of recommendations for prescribers of PPIs to ensure a balance of the benefits against the potential arrhythmic risks.","PeriodicalId":18976,"journal":{"name":"Nature Reviews Cardiology","volume":"93 1","pages":""},"PeriodicalIF":49.6,"publicationDate":"2024-12-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142797040","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Unlocking excellence in health care: the power of inclusive and sensitive language in medicine 开启卓越的医疗保健：包容性和敏感性语言在医学中的力量
IF 49.6 1区 医学
Nature Reviews Cardiology Pub Date : 2024-11-20 DOI: 10.1038/s41569-024-01101-2
Sarah M. Birkhoelzer, Sonia S. Anand
{"title":"Unlocking excellence in health care: the power of inclusive and sensitive language in medicine","authors":"Sarah M. Birkhoelzer, Sonia S. Anand","doi":"10.1038/s41569-024-01101-2","DOIUrl":"https://doi.org/10.1038/s41569-024-01101-2","url":null,"abstract":"This call to action aims to increase awareness of inclusive language in medicine to enhance the experiences of patients and staff and improve health outcomes. Recognizing that terms change, we urge all health-care professionals to advocate for their colleagues and patients. This responsibility to educate the community should not fall exclusively onto marginalized communities.","PeriodicalId":18976,"journal":{"name":"Nature Reviews Cardiology","volume":"69 1","pages":""},"PeriodicalIF":49.6,"publicationDate":"2024-11-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142673280","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Charting the future of cardiology with large language model artificial intelligence 用大语言模型人工智能描绘心脏病学的未来
IF 49.6 1区 医学
Nature Reviews Cardiology Pub Date : 2024-11-19 DOI: 10.1038/s41569-024-01105-y
Ramsey M. Wehbe
{"title":"Charting the future of cardiology with large language model artificial intelligence","authors":"Ramsey M. Wehbe","doi":"10.1038/s41569-024-01105-y","DOIUrl":"https://doi.org/10.1038/s41569-024-01105-y","url":null,"abstract":"Large language models represent a transformative leap in artificial intelligence and natural language processing, offering exciting potential across cardiology, from clinical care to education and research. However, several crucial challenges limit the practical implementation of large language models in cardiology. Interdisciplinary research is imperative to overcome these barriers.","PeriodicalId":18976,"journal":{"name":"Nature Reviews Cardiology","volume":"22 1","pages":""},"PeriodicalIF":49.6,"publicationDate":"2024-11-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142670677","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Cholesterol crystals in the pathogenesis of atherosclerosis. 动脉粥样硬化发病机制中的胆固醇结晶。
IF 41.7 1区 医学
Nature Reviews Cardiology Pub Date : 2024-11-18 DOI: 10.1038/s41569-024-01100-3
Yvonne Baumer, Jason Irei, William A Boisvert
{"title":"Cholesterol crystals in the pathogenesis of atherosclerosis.","authors":"Yvonne Baumer, Jason Irei, William A Boisvert","doi":"10.1038/s41569-024-01100-3","DOIUrl":"10.1038/s41569-024-01100-3","url":null,"abstract":"<p><p>The presence of cholesterol crystals (CCs) in tissues was first described more than 100 years ago. CCs have a pathogenic role in various cardiovascular diseases, including myocardial infarction, aortic aneurysm and, most prominently, atherosclerosis. Although the underlying mechanisms and signalling pathways involved in CC formation are incompletely understood, numerous studies have highlighted the existence of CCs at various stages of atheroma progression. In this Review, we summarize the mechanisms underlying CC formation and the role of CCs in cardiovascular disease. In particular, we explore the established links between lipid metabolism across various cell types and the formation of CCs, with a focus on CC occurrence in the vasculature. We also discuss CC-induced inflammation as one of the pathogenic features of CCs in the atheroma. Finally, we summarize the therapeutic strategies aimed at reducing CC-mediated atherosclerotic burden, including approaches to inhibit CC formation in the vasculature or to mitigate the inflammatory response triggered by CCs. Addressing CC formation might emerge as a crucial component in our broader efforts to combat cardiovascular disease.</p>","PeriodicalId":18976,"journal":{"name":"Nature Reviews Cardiology","volume":" ","pages":""},"PeriodicalIF":41.7,"publicationDate":"2024-11-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142668251","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Trials and tribulations of cell therapy for heart failure: an update on ongoing trials. 细胞疗法治疗心力衰竭的考验与磨难：正在进行的试验的最新情况。
IF 41.7 1区 医学
Nature Reviews Cardiology Pub Date : 2024-11-15 DOI: 10.1038/s41569-024-01098-8
Jianyi Jay Zhang, Steven M Pogwizd, Keiichi Fukuda, Wolfram-Hubertus Zimmermann, Chengming Fan, Joshua M Hare, Roberto Bolli, Philippe Menasché
{"title":"Trials and tribulations of cell therapy for heart failure: an update on ongoing trials.","authors":"Jianyi Jay Zhang, Steven M Pogwizd, Keiichi Fukuda, Wolfram-Hubertus Zimmermann, Chengming Fan, Joshua M Hare, Roberto Bolli, Philippe Menasché","doi":"10.1038/s41569-024-01098-8","DOIUrl":"https://doi.org/10.1038/s41569-024-01098-8","url":null,"abstract":"<p><p>Heart failure (HF) remains a leading cause of mortality, responsible for 13% of all deaths worldwide. The prognosis for patients with HF is poor, with only a 50% survival rate within 5 years. A major challenge of ischaemia-driven HF is the loss of cardiomyocytes, compounded by the minimal regenerative capacity of the adult heart. To date, replacement of irreversibly damaged heart muscle can only be achieved by complete heart transplantation. In the past 20 years, cell therapy has emerged and evolved as a promising avenue for cardiac repair and regeneration. During this time, cell therapy for HF has encountered substantial barriers in both preclinical studies and clinical trials but the field continues to progress and evolve from lessons learned from such research. In this Review, we provide an overview of ongoing trials of cell-based and cell product-based therapies for the treatment of HF. Findings from these trials will facilitate the clinical translation of cardiac regenerative and reparative therapies not only by evaluating the safety and efficacy of specific cell-based therapeutics but also by establishing the feasibility of novel or underexplored treatment protocols such as repeated intravenous dosing, personalized patient selection based on pharmacogenomics, systemic versus intramural cell delivery, and epicardial engraftment of engineered tissue products.</p>","PeriodicalId":18976,"journal":{"name":"Nature Reviews Cardiology","volume":" ","pages":""},"PeriodicalIF":41.7,"publicationDate":"2024-11-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142639368","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Trade-offs between vessel-based and substrate-based nomenclatures for coronary heart diseases. 基于血管和基于基质的冠心病命名法之间的权衡。
IF 41.7 1区 医学
Nature Reviews Cardiology Pub Date : 2024-11-14 DOI: 10.1038/s41569-024-01099-7
Robert A Byrne, Adnan Kastrati
{"title":"Trade-offs between vessel-based and substrate-based nomenclatures for coronary heart diseases.","authors":"Robert A Byrne, Adnan Kastrati","doi":"10.1038/s41569-024-01099-7","DOIUrl":"10.1038/s41569-024-01099-7","url":null,"abstract":"","PeriodicalId":18976,"journal":{"name":"Nature Reviews Cardiology","volume":" ","pages":""},"PeriodicalIF":41.7,"publicationDate":"2024-11-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142624329","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Improving English proficiency for scientific communication by non-fluent speakers. 提高非流利语言使用者的科学交流英语水平。
IF 41.7 1区 医学
Nature Reviews Cardiology Pub Date : 2024-11-14 DOI: 10.1038/s41569-024-01102-1
Dong Zhao, Maria Rubini
{"title":"Improving English proficiency for scientific communication by non-fluent speakers.","authors":"Dong Zhao, Maria Rubini","doi":"10.1038/s41569-024-01102-1","DOIUrl":"10.1038/s41569-024-01102-1","url":null,"abstract":"","PeriodicalId":18976,"journal":{"name":"Nature Reviews Cardiology","volume":" ","pages":""},"PeriodicalIF":41.7,"publicationDate":"2024-11-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142624279","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Monocytes migrate to the brain after MI to promote deep sleep to aid cardiac healing 心肌梗死后，单核细胞会迁移到大脑，以促进深度睡眠，帮助心脏愈合。
IF 41.7 1区 医学
Nature Reviews Cardiology Pub Date : 2024-11-14 DOI: 10.1038/s41569-024-01106-x
Irene Fernández-Ruiz
{"title":"Monocytes migrate to the brain after MI to promote deep sleep to aid cardiac healing","authors":"Irene Fernández-Ruiz","doi":"10.1038/s41569-024-01106-x","DOIUrl":"10.1038/s41569-024-01106-x","url":null,"abstract":"After myocardial infarction, monocytes are actively recruited to the brain to augment sleep power and abundance, which in turn helps to limit cardiac inflammation and promotes recovery.","PeriodicalId":18976,"journal":{"name":"Nature Reviews Cardiology","volume":"22 1","pages":"4-4"},"PeriodicalIF":41.7,"publicationDate":"2024-11-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142624324","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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