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Pulsed field ablation non-inferior to cryoablation for paroxysmal AF
IF 49.6 1区 医学
Nature Reviews Cardiology Pub Date : 2025-04-16 DOI: 10.1038/s41569-025-01159-6
Irene Fernández-Ruiz
{"title":"Pulsed field ablation non-inferior to cryoablation for paroxysmal AF","authors":"Irene Fernández-Ruiz","doi":"10.1038/s41569-025-01159-6","DOIUrl":"https://doi.org/10.1038/s41569-025-01159-6","url":null,"abstract":"In patients with symptomatic paroxysmal atrial fibrillation, pulsed field ablation is non-inferior to cryoballoon ablation for preventing the recurrence of atrial tachyarrhythmia, according to findings from the SINGLE SHOT CHAMPION trial.","PeriodicalId":18976,"journal":{"name":"Nature Reviews Cardiology","volume":"7 1","pages":""},"PeriodicalIF":49.6,"publicationDate":"2025-04-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143836689","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Expanding cardiovascular indications for semaglutide: results from the SOUL and STRIDE trials 扩大塞马鲁肽的心血管适应症：SOUL 和 STRIDE 试验的结果
IF 49.6 1区 医学
Nature Reviews Cardiology Pub Date : 2025-04-14 DOI: 10.1038/s41569-025-01158-7
Karina Huynh
{"title":"Expanding cardiovascular indications for semaglutide: results from the SOUL and STRIDE trials","authors":"Karina Huynh","doi":"10.1038/s41569-025-01158-7","DOIUrl":"https://doi.org/10.1038/s41569-025-01158-7","url":null,"abstract":"Two clinical trials presented at the ACC.25 describe the expanding indications for the glucagon-like peptide 1 receptor agonist semaglutide in patients with type 2 diabetes mellitus.","PeriodicalId":18976,"journal":{"name":"Nature Reviews Cardiology","volume":"49 1","pages":""},"PeriodicalIF":49.6,"publicationDate":"2025-04-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143831797","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Post-translational acylation of proteins in cardiac hypertrophy
IF 49.6 1区 医学
Nature Reviews Cardiology Pub Date : 2025-04-14 DOI: 10.1038/s41569-025-01150-1
Ying-Qi Liu, Qin Yang, Guo-Wei He
{"title":"Post-translational acylation of proteins in cardiac hypertrophy","authors":"Ying-Qi Liu, Qin Yang, Guo-Wei He","doi":"10.1038/s41569-025-01150-1","DOIUrl":"https://doi.org/10.1038/s41569-025-01150-1","url":null,"abstract":"<p>Acylations are post-translational modifications in which functional groups are attached to amino acids on proteins. Most acylations (acetylation, butyrylation, crotonylation, lactylation, malonylation, propionylation and succinylation) involve lysine but cysteine (palmitoylation) and glycine (myristoylation) residues can also be altered. Acylations have important roles in physiological and pathophysiological processes, including cardiac hypertrophy and related cardiovascular diseases. These post-translational modifications influence chromatin architecture, transcriptional regulation and metabolic pathways, thereby affecting cardiomyocyte function and pathology. The dynamic interaction between these acylations and their regulatory enzymes, such as histone acetyltransferases, histone deacetylases and sirtuins, underscores the complexity of cellular homeostasis and pathological processes. Emerging evidence highlights the therapeutic potential of targeting acylations to modulate enzyme activity and metabolite levels, offering promising avenues for novel treatments. In this Review, we explore the diverse mechanisms through which acylations contribute to cardiac hypertrophy, highlighting the complexity and potential therapeutic targets in this regulatory network.</p>","PeriodicalId":18976,"journal":{"name":"Nature Reviews Cardiology","volume":"183 1","pages":""},"PeriodicalIF":49.6,"publicationDate":"2025-04-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143827315","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
No effect of cerebral embolic protection devices on stroke risk after TAVI
IF 49.6 1区 医学
Nature Reviews Cardiology Pub Date : 2025-04-10 DOI: 10.1038/s41569-025-01156-9
Irene Fernández-Ruiz
{"title":"No effect of cerebral embolic protection devices on stroke risk after TAVI","authors":"Irene Fernández-Ruiz","doi":"10.1038/s41569-025-01156-9","DOIUrl":"https://doi.org/10.1038/s41569-025-01156-9","url":null,"abstract":"Findings from the BHF PROTECT-TAVI trial indicate that the routine use of cerebral embolic protection devices during transcatheter aortic valve implantation does not decrease the incidence of stroke within 72 h after the intervention.","PeriodicalId":18976,"journal":{"name":"Nature Reviews Cardiology","volume":"60 1","pages":""},"PeriodicalIF":49.6,"publicationDate":"2025-04-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143819332","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Development of a miniature, bioresorbable, light-activated pacemaker
IF 49.6 1区 医学
Nature Reviews Cardiology Pub Date : 2025-04-10 DOI: 10.1038/s41569-025-01157-8
Gregory B. Lim
{"title":"Development of a miniature, bioresorbable, light-activated pacemaker","authors":"Gregory B. Lim","doi":"10.1038/s41569-025-01157-8","DOIUrl":"https://doi.org/10.1038/s41569-025-01157-8","url":null,"abstract":"Researchers have engineered a millimetre-scale, bioresorbable, optoelectronic system that can be minimally invasively implanted into the heart and wirelessly controlled by a light source on the surface of the skin to provide temporary cardiac pacing.","PeriodicalId":18976,"journal":{"name":"Nature Reviews Cardiology","volume":"12 1","pages":""},"PeriodicalIF":49.6,"publicationDate":"2025-04-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143819246","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Apolipoprotein B100 revisited
IF 49.6 1区 医学
Nature Reviews Cardiology Pub Date : 2025-04-10 DOI: 10.1038/s41569-025-01155-w
Mia S. Manojlovic, Melaku Taye Amogne
{"title":"Apolipoprotein B100 revisited","authors":"Mia S. Manojlovic, Melaku Taye Amogne","doi":"10.1038/s41569-025-01155-w","DOIUrl":"https://doi.org/10.1038/s41569-025-01155-w","url":null,"abstract":"Mia Manojlovic and Melaku Taye Amogne highlight the 1986 study that unravelled the primary structure of apolipoprotein B100 and laid a foundation for subsequent studies on the role of this apolipoprotein.","PeriodicalId":18976,"journal":{"name":"Nature Reviews Cardiology","volume":"4 1","pages":""},"PeriodicalIF":49.6,"publicationDate":"2025-04-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143813465","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Primordial prevention of cardiovascular disease
IF 49.6 1区 医学
Nature Reviews Cardiology Pub Date : 2025-04-08 DOI: 10.1038/s41569-025-01153-y
Hooi Min Lim
{"title":"Primordial prevention of cardiovascular disease","authors":"Hooi Min Lim","doi":"10.1038/s41569-025-01153-y","DOIUrl":"https://doi.org/10.1038/s41569-025-01153-y","url":null,"abstract":"Hooi Min Lim describes how the Bogalusa Heart Study emphasized the importance of primordial prevention of cardiovascular disease and profoundly influenced subsequent cardiovascular research on children and adolescents.","PeriodicalId":18976,"journal":{"name":"Nature Reviews Cardiology","volume":"34 1","pages":""},"PeriodicalIF":49.6,"publicationDate":"2025-04-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143797662","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Molecular gatekeepers of endogenous adult mammalian cardiomyocyte proliferation
IF 49.6 1区 医学
Nature Reviews Cardiology Pub Date : 2025-04-07 DOI: 10.1038/s41569-025-01145-y
Tim Koopmans, Eva van Rooij
{"title":"Molecular gatekeepers of endogenous adult mammalian cardiomyocyte proliferation","authors":"Tim Koopmans, Eva van Rooij","doi":"10.1038/s41569-025-01145-y","DOIUrl":"https://doi.org/10.1038/s41569-025-01145-y","url":null,"abstract":"<p>Irreversible cardiac fibrosis, cardiomyocyte death and chronic cardiac dysfunction after myocardial infarction pose a substantial global health-care challenge, with no curative treatments available. To regenerate the injured heart, cardiomyocytes must proliferate to replace lost myocardial tissue — a capability that adult mammals have largely forfeited to adapt to the demanding conditions of life. Using various preclinical models, our understanding of cardiomyocyte proliferation has progressed remarkably, leading to the successful reactivation of cell cycle induction in adult animals, with functional recovery after cardiac injury. Central to this success is the targeting of key pathways and structures that drive cardiomyocyte maturation after birth — nucleation and ploidy, sarcomere structure, developmental signalling, chromatin and epigenetic regulation, the microenvironment and metabolic maturation — forming a complex regulatory framework that allows efficient cellular contraction but restricts cardiomyocyte proliferation. In this Review, we explore the molecular pathways underlying these core mechanisms and how their manipulation can reactivate the cell cycle in cardiomyocytes, potentially contributing to cardiac repair.</p>","PeriodicalId":18976,"journal":{"name":"Nature Reviews Cardiology","volume":"16 1","pages":""},"PeriodicalIF":49.6,"publicationDate":"2025-04-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143789852","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
A turning point in cardiac remodelling in obesity
IF 49.6 1区 医学
Nature Reviews Cardiology Pub Date : 2025-04-07 DOI: 10.1038/s41569-025-01154-x
Mariella R. Huaman, Carlos J. Toro-Huamanchumo
{"title":"A turning point in cardiac remodelling in obesity","authors":"Mariella R. Huaman, Carlos J. Toro-Huamanchumo","doi":"10.1038/s41569-025-01154-x","DOIUrl":"https://doi.org/10.1038/s41569-025-01154-x","url":null,"abstract":"Mariella Huaman and Carlos Toro-Huamanchumo discuss the 2013 study that provided crucial insights into the cardiac structural changes associated with obesity and challenged previously established paradigms.","PeriodicalId":18976,"journal":{"name":"Nature Reviews Cardiology","volume":"39 1","pages":""},"PeriodicalIF":49.6,"publicationDate":"2025-04-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143789851","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Preserving the future of heart transplantation
IF 49.6 1区 医学
Nature Reviews Cardiology Pub Date : 2025-04-04 DOI: 10.1038/s41569-025-01146-x
David M. Kaye, David C. McGiffin
{"title":"Preserving the future of heart transplantation","authors":"David M. Kaye, David C. McGiffin","doi":"10.1038/s41569-025-01146-x","DOIUrl":"https://doi.org/10.1038/s41569-025-01146-x","url":null,"abstract":"Heart transplantation remains the optimal long-term treatment for appropriate patients with advanced heart failure. However, the donor heart shortage is a limiting factor, and the risk profile of transplant candidates is worsening. In this landscape, the utility of conventional cold static storage for donor hearts is increasingly limited. In this Clinical Outlook, we discuss new methods of donor heart preservation that are transforming the future of heart transplantation.","PeriodicalId":18976,"journal":{"name":"Nature Reviews Cardiology","volume":"33 1","pages":""},"PeriodicalIF":49.6,"publicationDate":"2025-04-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143775567","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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