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Nature Reviews Cardiology最新文献

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Duration of antibiotic treatment for infective endocarditis: should we move towards tailored therapy? 抗生素治疗感染性心内膜炎的持续时间：我们是否应该转向量身定制的治疗？
IF 50.2 1区 医学
Nature Reviews Cardiology Pub Date : 2026-10-15 DOI: 10.1038/s41569-026-01360-1
Mary Philip, Gilbert Habib
{"title":"Duration of antibiotic treatment for infective endocarditis: should we move towards tailored therapy?","authors":"Mary Philip, Gilbert Habib","doi":"10.1038/s41569-026-01360-1","DOIUrl":"https://doi.org/10.1038/s41569-026-01360-1","url":null,"abstract":"","PeriodicalId":18976,"journal":{"name":"Nature Reviews Cardiology","volume":" ","pages":""},"PeriodicalIF":50.2,"publicationDate":"2026-10-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149194653","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Heart-specific T cell responses: from antigens to disease mechanisms. 心脏特异性T细胞反应：从抗原到疾病机制。
IF 50.2 1区 医学
Nature Reviews Cardiology Pub Date : 2026-10-12 DOI: 10.1038/s41569-026-01356-x
Gustavo Campos Ramos
{"title":"Heart-specific T cell responses: from antigens to disease mechanisms.","authors":"Gustavo Campos Ramos","doi":"10.1038/s41569-026-01356-x","DOIUrl":"https://doi.org/10.1038/s41569-026-01356-x","url":null,"abstract":"<p><p>The field of immunology has transformed our understanding of myocardial cell biology and paved the way for new pathophysiological concepts in cardiology. Researchers have sought to elucidate the contributions of nonspecific inflammatory mechanisms to cardiac diseases, and an increasing number of clinical trials have explored anti-inflammatory approaches in cardiovascular disease. Moreover, adaptive immune mechanisms directed to cardiac proteins released by dying cardiomyocytes have been reported across a broad spectrum of conditions, including acute myocarditis, myocardial infarction and heart failure, and have gained increasing attention. This concept of antigen-specific cardio-immune crosstalk could pave the way for a deeper understanding of tissue-specific disease mechanisms and facilitate the development of targeted interventions. However, only a small number of cardiac antigens have been identified so far, and an immunological definition of heart specificity remains elusive. This Review revisits the molecular composition of the heart from the perspective of T cells to describe the most relevant cardiac antigens identified to date, thus defining a framework for identifying novel T cell reactivities in the injured heart. Going forward, these insights might pave the way for the development of new tools to track specific T cells across various cardiac diseases, in contexts ranging from model organisms to patients.</p>","PeriodicalId":18976,"journal":{"name":"Nature Reviews Cardiology","volume":" ","pages":""},"PeriodicalIF":50.2,"publicationDate":"2026-10-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149170176","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Beyond glucose lowering and ketogenesis: unveiling new cardioprotective mechanisms of SGLT2 inhibitors 超越降糖和生酮：揭示SGLT2抑制剂的新的心脏保护机制
IF 49.6 1区 医学
Nature Reviews Cardiology Pub Date : 2026-10-02 DOI: 10.1038/s41569-026-01357-w
Alessia Riccio,Gaetano Santulli
{"title":"Beyond glucose lowering and ketogenesis: unveiling new cardioprotective mechanisms of SGLT2 inhibitors","authors":"Alessia Riccio,Gaetano Santulli","doi":"10.1038/s41569-026-01357-w","DOIUrl":"https://doi.org/10.1038/s41569-026-01357-w","url":null,"abstract":"","PeriodicalId":18976,"journal":{"name":"Nature Reviews Cardiology","volume":"36 1","pages":""},"PeriodicalIF":49.6,"publicationDate":"2026-10-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149087951","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Global burden of venous thromboembolism: incidence and outcome estimates of deep-vein thrombosis and pulmonary embolism 静脉血栓栓塞的全球负担：深静脉血栓形成和肺栓塞的发生率和结局估计
IF 49.6 1区 医学
Nature Reviews Cardiology Pub Date : 2026-09-27 DOI: 10.1038/s41569-026-01334-3
Behnood Bikdeli,Sina Rashedi,Mariana Pfeferman,Christopher Amalan,Hannah Leyva,Darsiya Krishnathasan,Syed Bukhari,Burton H. Shen,Eric A. Secemsky,Zhenguo Zhai,Yugo Yamashita,Mitsuaki Sawano,Pantep Angchaisuksiri,David Jimenez,Manuel Monreal,Parham Sadeghipour,Marco Zuin,Laurent Bertoletti,Eduardo Ramacciotti,Frederikus A. Klok,Faizan Khan,Harry Gibbs,Stefano Barco,Jean Jacques Noubiap,Samuel Z. Goldhaber,Alexander T. Cohen,Gregory Y. H. Lip,Jean M. Connors,Jeffrey I. Weitz,Lisa K. Moores,Andrei Kindzelski,George A. Mensah,Mary Cushman,Harlan M. Krumholz,Gregory Piazza
{"title":"Global burden of venous thromboembolism: incidence and outcome estimates of deep-vein thrombosis and pulmonary embolism","authors":"Behnood Bikdeli,Sina Rashedi,Mariana Pfeferman,Christopher Amalan,Hannah Leyva,Darsiya Krishnathasan,Syed Bukhari,Burton H. Shen,Eric A. Secemsky,Zhenguo Zhai,Yugo Yamashita,Mitsuaki Sawano,Pantep Angchaisuksiri,David Jimenez,Manuel Monreal,Parham Sadeghipour,Marco Zuin,Laurent Bertoletti,Eduardo Ramacciotti,Frederikus A. Klok,Faizan Khan,Harry Gibbs,Stefano Barco,Jean Jacques Noubiap,Samuel Z. Goldhaber,Alexander T. Cohen,Gregory Y. H. Lip,Jean M. Connors,Jeffrey I. Weitz,Lisa K. Moores,Andrei Kindzelski,George A. Mensah,Mary Cushman,Harlan M. Krumholz,Gregory Piazza","doi":"10.1038/s41569-026-01334-3","DOIUrl":"https://doi.org/10.1038/s41569-026-01334-3","url":null,"abstract":"","PeriodicalId":18976,"journal":{"name":"Nature Reviews Cardiology","volume":"101 1","pages":""},"PeriodicalIF":49.6,"publicationDate":"2026-09-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149048900","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Beating the odds: bringing the human heart into a dish. 克服困难：将人类心脏放入培养皿。
IF 50.2 1区 医学
Nature Reviews Cardiology Pub Date : 2026-09-17 DOI: 10.1038/s41569-026-01355-y
Marcos Castro-Guarda, Jolanda van der Velden
{"title":"Beating the odds: bringing the human heart into a dish.","authors":"Marcos Castro-Guarda, Jolanda van der Velden","doi":"10.1038/s41569-026-01355-y","DOIUrl":"https://doi.org/10.1038/s41569-026-01355-y","url":null,"abstract":"","PeriodicalId":18976,"journal":{"name":"Nature Reviews Cardiology","volume":" ","pages":""},"PeriodicalIF":50.2,"publicationDate":"2026-09-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148990567","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Benefit of aficamten in non-obstructive hypertrophic cardiomyopathy 阿菲坎坦治疗非阻塞性肥厚性心肌病的疗效。
IF 50.2 1区 医学
Nature Reviews Cardiology Pub Date : 2026-09-16 DOI: 10.1038/s41569-026-01353-0
Gregory B. Lim
{"title":"Benefit of aficamten in non-obstructive hypertrophic cardiomyopathy","authors":"Gregory B. Lim","doi":"10.1038/s41569-026-01353-0","DOIUrl":"10.1038/s41569-026-01353-0","url":null,"abstract":"Data from the ACACIA-HCM trial show that treatment with the myosin inhibitor aficamten improves exercise capacity and patient-reported health status compared with placebo in patients with non-obstructive hypertrophic cardiomyopathy.","PeriodicalId":18976,"journal":{"name":"Nature Reviews Cardiology","volume":"23 11","pages":"760-760"},"PeriodicalIF":50.2,"publicationDate":"2026-09-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148983114","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
High-altitude hypoxia and congenital heart defects. 高原缺氧和先天性心脏缺陷。
IF 50.2 1区 医学
Nature Reviews Cardiology Pub Date : 2026-09-15 DOI: 10.1038/s41569-026-01352-1
J Pierre Zila-Velasque
{"title":"High-altitude hypoxia and congenital heart defects.","authors":"J Pierre Zila-Velasque","doi":"10.1038/s41569-026-01352-1","DOIUrl":"https://doi.org/10.1038/s41569-026-01352-1","url":null,"abstract":"","PeriodicalId":18976,"journal":{"name":"Nature Reviews Cardiology","volume":" ","pages":""},"PeriodicalIF":50.2,"publicationDate":"2026-09-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148977258","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Pulmonary artery denervation shows promising results for heart failure-related pulmonary hypertension 肺动脉去神经支配治疗心力衰竭相关性肺动脉高压的效果令人鼓舞。
IF 50.2 1区 医学
Nature Reviews Cardiology Pub Date : 2026-09-15 DOI: 10.1038/s41569-026-01350-3
Irene Fernández-Ruiz
{"title":"Pulmonary artery denervation shows promising results for heart failure-related pulmonary hypertension","authors":"Irene Fernández-Ruiz","doi":"10.1038/s41569-026-01350-3","DOIUrl":"10.1038/s41569-026-01350-3","url":null,"abstract":"Pulmonary artery denervation lowers the risk of clinical worsening in patients with pulmonary hypertension caused by left-sided heart disease and associated with heart failure who remain symptomatic despite treatment with guideline-directed medical therapy, according to findings from the PADN-HF-PH trial.","PeriodicalId":18976,"journal":{"name":"Nature Reviews Cardiology","volume":"23 11","pages":"761-761"},"PeriodicalIF":50.2,"publicationDate":"2026-09-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148977305","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Tricuspid valve repair reduces death and HF hospitalization 三尖瓣修复可减少死亡和心衰住院。
IF 50.2 1区 医学
Nature Reviews Cardiology Pub Date : 2026-09-15 DOI: 10.1038/s41569-026-01351-2
Karina Huynh
{"title":"Tricuspid valve repair reduces death and HF hospitalization","authors":"Karina Huynh","doi":"10.1038/s41569-026-01351-2","DOIUrl":"10.1038/s41569-026-01351-2","url":null,"abstract":"In patients with symptomatic severe tricuspid regurgitation, transcatheter tricuspid repair in addition to medical therapy not only improves quality of life compared with medical therapy alone, but also significantly reduces the risk of all-cause death and hospitalization for heart failure, according to the results from the investigator-initiated TRIC-I-HF-DZHK24 trial.","PeriodicalId":18976,"journal":{"name":"Nature Reviews Cardiology","volume":"23 11","pages":"762-762"},"PeriodicalIF":50.2,"publicationDate":"2026-09-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148977323","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Genetic cardiomyopathy-associated myocarditis. 遗传性心肌病相关心肌炎。
IF 50.2 1区 医学
Nature Reviews Cardiology Pub Date : 2026-09-08 DOI: 10.1038/s41569-026-01349-w
Tobias Lerchner, Stephane S R Heymans
{"title":"Genetic cardiomyopathy-associated myocarditis.","authors":"Tobias Lerchner, Stephane S R Heymans","doi":"10.1038/s41569-026-01349-w","DOIUrl":"https://doi.org/10.1038/s41569-026-01349-w","url":null,"abstract":"","PeriodicalId":18976,"journal":{"name":"Nature Reviews Cardiology","volume":" ","pages":""},"PeriodicalIF":50.2,"publicationDate":"2026-09-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148912050","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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