Nature Reviews Cardiology最新文献_第10页

Artificially transplanted mitochondria in endothelial cells promote mitophagy 内皮细胞中人工移植的线粒体可促进有丝分裂。

IF 49.6 1区医学

Nature Reviews Cardiology Pub Date : 2024-05-21 DOI: 10.1038/s41569-024-01041-x

Karina Huynh

引用次数: 0

Bile acid receptor protects against diabetic cardiomyopathy 胆汁酸受体可预防糖尿病心肌病

IF 49.6 1区医学

Nature Reviews Cardiology Pub Date : 2024-05-20 DOI: 10.1038/s41569-024-01040-y

Irene Fernández-Ruiz

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Efferocytosis in atherosclerosis 动脉粥样硬化中的吞噬作用

IF 41.7 1区医学

Nature Reviews Cardiology Pub Date : 2024-05-15 DOI: 10.1038/s41569-024-01037-7

Shaunak S. Adkar, Nicholas J. Leeper

{"title":"Efferocytosis in atherosclerosis","authors":"Shaunak S. Adkar, Nicholas J. Leeper","doi":"10.1038/s41569-024-01037-7","DOIUrl":"10.1038/s41569-024-01037-7","url":null,"abstract":"Cardiovascular disease is the leading cause of death worldwide, and it commonly results from atherosclerotic plaque progression. One of the increasingly recognized drivers of atherosclerosis is dysfunctional efferocytosis, a homeostatic mechanism responsible for the clearance of dead cells and the resolution of inflammation. In atherosclerosis, the capacity of phagocytes to participate in efferocytosis is hampered, leading to the accumulation of apoptotic and necrotic tissue within the plaque, which results in enlargement of the necrotic core, increased luminal stenosis and plaque inflammation, and predisposition to plaque rupture or erosion. In this Review, we describe the different forms of programmed cell death that can occur in the atherosclerotic plaque and highlight the efferocytic machinery that is normally implicated in cardiovascular physiology. We then discuss the mechanisms by which efferocytosis fails in atherosclerosis and other cardiovascular and cardiometabolic diseases, including myocardial infarction and diabetes mellitus, and discuss therapeutic approaches that might reverse this pathological process. In this Review, Adkar and Leeper describe the mechanisms of programmed cell death and efferocytosis, discuss how efferocytosis becomes impaired in atherosclerosis and other cardiometabolic diseases, and suggest potential strategies to target these pathways for the treatment of atherosclerotic cardiovascular disease.","PeriodicalId":18976,"journal":{"name":"Nature Reviews Cardiology","volume":"21 11","pages":"762-779"},"PeriodicalIF":41.7,"publicationDate":"2024-05-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.nature.com/articles/s41569-024-01037-7.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140925028","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Illusion of revascularization: does anyone achieve optimal revascularization during percutaneous coronary intervention? 血管再通的假象：是否有人在经皮冠状动脉介入治疗过程中实现了最佳血管再通？

IF 41.7 1区医学

Nature Reviews Cardiology Pub Date : 2024-05-07 DOI: 10.1038/s41569-024-01014-0

Simone Fezzi, Daixin Ding, Felix Mahfoud, Jiayue Huang, Alexandra J. Lansky, Shengxian Tu, William Wijns

{"title":"Illusion of revascularization: does anyone achieve optimal revascularization during percutaneous coronary intervention?","authors":"Simone Fezzi, Daixin Ding, Felix Mahfoud, Jiayue Huang, Alexandra J. Lansky, Shengxian Tu, William Wijns","doi":"10.1038/s41569-024-01014-0","DOIUrl":"10.1038/s41569-024-01014-0","url":null,"abstract":"This Perspective article is a form of ‘pastiche’, inspired by the 1993 review by Lincoff and Topol entitled ‘Illusion of reperfusion’, and explores how their concept continues to apply to percutaneous revascularization in patients with coronary artery disease and ischaemia. Just as Lincoff and Topol argued that reperfusion of acute myocardial infarction was facing unresolved obstacles that hampered clinical success in 1993, we propose that challenging issues are similarly jeopardizing the potential benefits of stent-based angioplasty today. By analysing the appropriateness and efficacy of percutaneous coronary intervention (PCI), we emphasize the limitations of relying solely on visual angiographic guidance, which frequently leads to inappropriate stenting and overtreatment in up to one-third of patients and the associated increased risk of periprocedural myocardial infarction. The lack of optimal revascularization observed in half of patients undergoing PCI confers risks such as suboptimal physiology after PCI, residual angina and long-term stent-related events, leaving an estimated 76% of patients with an ‘illusion of revascularization’. These outcomes highlight the need to refine our diagnostic tools by integrating physiological assessments with targeted intracoronary imaging and emerging strategies, such as co-registration systems and angiography-based computational methods enhanced by artificial intelligence, to achieve optimal revascularization outcomes. In 1993, Lincoff and Topol claimed that the thrombolytic treatment of ST-segment elevation myocardial infarction was suboptimal in many patients and gave an ‘illusion of reperfusion’. In this Perspective article, the authors propose that a similar illusion of revascularization exists for contemporary percutaneous revascularization in patients with coronary artery disease and ischaemia, and identify how outcomes might be improved.","PeriodicalId":18976,"journal":{"name":"Nature Reviews Cardiology","volume":"21 9","pages":"652-662"},"PeriodicalIF":41.7,"publicationDate":"2024-05-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140845335","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

No benefit of apoA-I infusion after myocardial infarction 心肌梗死后输注载脂蛋白 A-I 无益

IF 49.6 1区医学

Nature Reviews Cardiology Pub Date : 2024-05-03 DOI: 10.1038/s41569-024-01031-z

Gregory B. Lim

引用次数: 0

Stress and cardiovascular disease: an update 压力与心血管疾病：最新进展

IF 41.7 1区医学

Nature Reviews Cardiology Pub Date : 2024-05-02 DOI: 10.1038/s41569-024-01024-y

Viola Vaccarino, J. Douglas Bremner

{"title":"Stress and cardiovascular disease: an update","authors":"Viola Vaccarino, J. Douglas Bremner","doi":"10.1038/s41569-024-01024-y","DOIUrl":"10.1038/s41569-024-01024-y","url":null,"abstract":"Psychological stress is generally accepted to be associated with an increased risk of cardiovascular disease (CVD), but results have varied in terms of how stress is measured and the strength of the association. Additionally, the mechanisms and potential causal links have remained speculative despite decades of research. The physiological responses to stress are well characterized, but their contribution to the development and progression of CVD has received little attention in empirical studies. Evidence suggests that physiological responses to stress have a fundamental role in the risk of CVD and that haemodynamic, vascular and immune perturbations triggered by stress are especially implicated. Stress response physiology is regulated by the corticolimbic regions of the brain, which have outputs to the autonomic nervous system. Variation in these regulatory pathways might explain interindividual differences in vulnerability to stress. Dynamic perturbations in autonomic, immune and vascular functions are probably also implicated as CVD risk mechanisms of chronic, recurring and cumulative stressful exposures, but more data are needed from prospective studies and from assessments in real-life situations. Psychological assessment remains insufficiently recognized in clinical care and prevention. Although stress-reduction interventions might mitigate perceived stress levels and potentially reduce cardiovascular risk, more data from randomized trials are needed. Physiological responses to stress are thought to increase the risk of cardiovascular disease via haemodynamic, vascular and immune perturbations. In this Review, Vaccarino and Bremner focus on issues with the measurement of psychological stress and the underlying pathobiology connecting stress to the risk of cardiovascular disease.","PeriodicalId":18976,"journal":{"name":"Nature Reviews Cardiology","volume":"21 9","pages":"603-616"},"PeriodicalIF":41.7,"publicationDate":"2024-05-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140819523","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Screening for Helicobacter pylori infection in patients with cardiovascular and gastrointestinal disease 筛查心血管和胃肠道疾病患者的幽门螺旋杆菌感染。

IF 41.7 1区医学

Nature Reviews Cardiology Pub Date : 2024-05-02 DOI: 10.1038/s41569-024-01028-8

Jonatan Wärme, Martin O. Sundqvist, Stefan James, Robin Hofmann

引用次数: 0

Reply to ‘Screening for Helicobacter pylori infection in patients with cardiovascular and gastrointestinal disease’ 对 "心血管和胃肠道疾病患者幽门螺杆菌感染筛查 "的答复

IF 41.7 1区医学

Nature Reviews Cardiology Pub Date : 2024-05-02 DOI: 10.1038/s41569-024-01029-7

Azita H. Talasaz, Behnood Bikdeli

引用次数: 0

Periodontal treatment reduces AF recurrence 牙周治疗可减少房颤复发

IF 49.6 1区医学

Nature Reviews Cardiology Pub Date : 2024-04-25 DOI: 10.1038/s41569-024-01036-8

Gregory B. Lim

引用次数: 0

Targeting immune cell recruitment in atherosclerosis 以动脉粥样硬化中的免疫细胞招募为目标

IF 41.7 1区医学

Nature Reviews Cardiology Pub Date : 2024-04-25 DOI: 10.1038/s41569-024-01023-z

Yvonne Döring, Emiel P. C. van der Vorst, Christian Weber

{"title":"Targeting immune cell recruitment in atherosclerosis","authors":"Yvonne Döring, Emiel P. C. van der Vorst, Christian Weber","doi":"10.1038/s41569-024-01023-z","DOIUrl":"10.1038/s41569-024-01023-z","url":null,"abstract":"Atherosclerosis is the primary underlying cause of myocardial infarction and stroke. Atherosclerotic cardiovascular disease is characterized by a chronic inflammatory reaction in medium-to-large-sized arteries, with its onset and perpetuation driven by leukocytes infiltrating the subendothelial space. Activation of endothelial cells triggered by hyperlipidaemia and lipoprotein retention in the arterial intima initiates the accumulation of pro-inflammatory leukocytes in the arterial wall, fostering the progression of atherosclerosis. This inflammatory response is coordinated by an array of soluble mediators, namely cytokines and chemokines, that amplify inflammation both locally and systemically and are complemented by tissue-specific molecules that regulate the homing, adhesion and transmigration of leukocytes. Despite abundant evidence from mouse models, only a few therapies targeting leukocytes in atherosclerosis have been assessed in humans. The major challenges for the clinical translation of these therapies include the lack of tissue specificity and insufficient selectivity of inhibition strategies. In this Review, we discuss the latest research on receptor–ligand pairs and interactors that regulate leukocyte influx into the inflamed artery wall, primarily focusing on studies that used pharmacological interventions. We also discuss mechanisms that promote the resolution of inflammation and highlight how major findings from these research areas hold promise as potential therapeutic strategies for atherosclerotic cardiovascular disease. In this Review, the authors discuss the receptors, ligands and interactors that regulate immune cell recruitment in atherosclerosis, describe mechanisms that promote the resolution of inflammation in atherosclerotic lesions, and highlight potential strategies to target these pathways for the treatment of atherosclerotic cardiovascular disease.","PeriodicalId":18976,"journal":{"name":"Nature Reviews Cardiology","volume":"21 11","pages":"824-840"},"PeriodicalIF":41.7,"publicationDate":"2024-04-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.nature.com/articles/s41569-024-01023-z.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140648752","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0