Nature Reviews Cardiology最新文献

{"title":"Home-based care improves blood pressure control","authors":"Irene Fernández-Ruiz","doi":"10.1038/s41569-025-01214-2","DOIUrl":"10.1038/s41569-025-01214-2","url":null,"abstract":"A home-based model of hypertension care can lower blood pressure in patients with hypertension compared with standard care in the clinic, according to the IMPACT-BP trial, which was performed in a rural setting in South Africa and presented at the ESC Congress 2025.","PeriodicalId":18976,"journal":{"name":"Nature Reviews Cardiology","volume":"22 11","pages":"841-841"},"PeriodicalIF":44.2,"publicationDate":"2025-09-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145025434","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Role of Helicobacter pylori screening after myocardial infarction","authors":"Irene Fernández-Ruiz","doi":"10.1038/s41569-025-01215-1","DOIUrl":"10.1038/s41569-025-01215-1","url":null,"abstract":"Routine screening for Helicobacter pylori infection during hospitalization for myocardial infarction does not reduce the risk of upper gastrointestinal bleeding, according to findings from the HELP-MI SWEDEHEART trial, although secondary and subgroup analyses suggest potential clinically meaningful benefits.","PeriodicalId":18976,"journal":{"name":"Nature Reviews Cardiology","volume":"22 11","pages":"841-841"},"PeriodicalIF":44.2,"publicationDate":"2025-09-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145026022","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Description of the cardiomyocyte sarcolemma by Ramón y Cajal","authors":"Jorge Peña Peña","doi":"10.1038/s41569-025-01213-3","DOIUrl":"10.1038/s41569-025-01213-3","url":null,"abstract":"Jorge Peña Peña highlights the 1888 publication from Santiago Ramón y Cajal that provided the first description of the cardiomyocyte sarcolemma.","PeriodicalId":18976,"journal":{"name":"Nature Reviews Cardiology","volume":"22 12","pages":"919-919"},"PeriodicalIF":44.2,"publicationDate":"2025-09-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145017618","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Transcriptional regulation in heart development, disease and regeneration: reassessing the fetal gene hypothesis","authors":"Enzo R. Porrello, Chang Jie Mick Lee, Roger S. Y. Foo, David A. Elliott","doi":"10.1038/s41569-025-01205-3","DOIUrl":"10.1038/s41569-025-01205-3","url":null,"abstract":"A central paradigm in cardiac biology is the reactivation of the fetal gene programme in the adult heart in response to stress. This so-called ‘fetal gene hypothesis’ was first proposed almost 40 years ago following the observation that certain fetal contractile protein isoforms were re-expressed in hypertrophied ventricles in the rodent heart in response to haemodynamic overload. Consequently, this concept was broadly adopted, and activation of the fetal gene programme became synonymous in the literature with the cardiac stress response. Transcriptomic and epigenomic profiling studies from the past 20 years have revealed the extent to which the diseased heart redeploys fetal gene programmes in response to stress. In this Review, we describe the historical origins of the fetal gene hypothesis and re-evaluate the general principles of fetal gene regulation in heart development, disease and regeneration. In this Review, Porrello and colleagues describe the origins of the fetal gene hypothesis and discuss the evolution of this hypothesis by considering more recent evidence from genome-wide sequencing studies.","PeriodicalId":18976,"journal":{"name":"Nature Reviews Cardiology","volume":"23 3","pages":"183-196"},"PeriodicalIF":44.2,"publicationDate":"2025-09-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144995331","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Building the Australian Cardiovascular disease Data Commons","authors":"Corey Giles, Peter J. Meikle","doi":"10.1038/s41569-025-01208-0","DOIUrl":"10.1038/s41569-025-01208-0","url":null,"abstract":"In this Tools of the Trade article, Giles and Meikle describe the development of the the Australian Cardiovascular disease Data Commons, which provides a comprehensive, secure, scalable and internationally integrated database containing pooled data from approximately 400,000 individuals in Australia.","PeriodicalId":18976,"journal":{"name":"Nature Reviews Cardiology","volume":"22 11","pages":"837-837"},"PeriodicalIF":44.2,"publicationDate":"2025-09-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144928250","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Synthetic ion channel modulator reverses sodium channel dysfunction linked to cardiac arrhythmias","authors":"Karina Huynh","doi":"10.1038/s41569-025-01207-1","DOIUrl":"10.1038/s41569-025-01207-1","url":null,"abstract":"Investigators of a new study published in Cell have engineered a new peptide modulator that binds to sodium channels to inhibit the late sodium current, which was shown to reverse the effects of sodium channel dysfunction associated with cardiac arrhythmias and epilepsy.","PeriodicalId":18976,"journal":{"name":"Nature Reviews Cardiology","volume":"22 11","pages":"839-839"},"PeriodicalIF":44.2,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144923936","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Creating an atlas of variant effects to resolve variants of uncertain significance and guide cardiovascular medicine","authors":"Andrew M. Glazer, Daniel R. Tabet, Victoria N. Parikh, Brett M. Kroncke, Atina G. Cote, Yuta Yamamoto, Qianru Wang, Ayesha Muhammad, Megan C. Lancaster, Matthew J. O’Neill, Jochen Weile, Tao Yang, Calum A. Macrae, Euan A. Ashley, Frederick P. Roth, Dan M. Roden","doi":"10.1038/s41569-025-01201-7","DOIUrl":"10.1038/s41569-025-01201-7","url":null,"abstract":"Cardiovascular diseases are leading global causes of death and disability, often presenting as interrelated phenotypes of atherosclerotic vascular disease, heart failure and arrhythmias. Cardiovascular diseases arise from interactions between environmental factors and predisposing genotypes and include common Mendelian lipid disorders, cardiomyopathies and arrhythmia syndromes. The identification of a pathogenic variant through genetic testing can inform disease diagnosis, risk prediction, treatment and family screening. However, a major roadblock in genomic medicine is that for many variants, especially missense variants, we lack sufficient evidence to enable a definitive classification, and therefore these variants are deemed as ‘variants of uncertain significance’. In this Review, we describe how multiplexed assays of variant effects can enable the functional assessment of nearly all coding variants in a target sequence, potentially offering a proactive approach to identifying the functional significance of gene variants that are observed later in a patient. We discuss validation, including the role of in silico variant effect predictors, and how multiplexed experimental methods are informing cardiovascular disease biology and ultimately resolving the problem of variants of uncertain significance at scale. In this Review, Roden and co-workers describe how multiplexed assays of variant effects can be used for high-throughput functional assessment of nearly all coding variants in a target sequence to improve variant annotation for cardiovascular-related genes and to resolve the problem of classification as variants of uncertain significance. They also discuss how variant effect predictors can be integrated with multiplexed methods to inform cardiovascular genomic medicine.","PeriodicalId":18976,"journal":{"name":"Nature Reviews Cardiology","volume":"23 3","pages":"149-163"},"PeriodicalIF":44.2,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144928599","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A deepening digital divide in cardiovascular disease management","authors":"Lu Yang, Abha Shrestha","doi":"10.1038/s41569-025-01206-2","DOIUrl":"10.1038/s41569-025-01206-2","url":null,"abstract":"Lu Yang and Abha Shrestha revisit the first large-scale trial to investigate the effects of telemonitoring on heart failure outcomes and link the lessons learned from the trial to current digital health strategies and challenges.","PeriodicalId":18976,"journal":{"name":"Nature Reviews Cardiology","volume":"22 12","pages":"918-918"},"PeriodicalIF":44.2,"publicationDate":"2025-08-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144899201","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Overcoming difficulties with resilience","authors":"Julia Grapsa","doi":"10.1038/s41569-025-01202-6","DOIUrl":"10.1038/s41569-025-01202-6","url":null,"abstract":"Difficulties, whether arising from work, academic or family environments, are a part of our life. A crucial part of our lives is our response to crisis and how we achieve resilience. In this sense, it is very important to try to turn negative experiences into positive — or at least constructive — experiences. In this Comment, I discuss how to achieve resilience in difficult times.","PeriodicalId":18976,"journal":{"name":"Nature Reviews Cardiology","volume":"22 11","pages":"833-834"},"PeriodicalIF":44.2,"publicationDate":"2025-08-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144851389","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Emerging AI tools for geospatially resolved cardiovascular risk","authors":"Zhuo Chen, Jean Eudes Dazard, Salil Deo, Sadeer Al-Kindi, Sanjay Rajagopalan","doi":"10.1038/s41569-025-01204-4","DOIUrl":"10.1038/s41569-025-01204-4","url":null,"abstract":"Artificial intelligence (AI) technologies are revolutionizing cardiovascular health by analysing environmental factors at an unprecedented scale. Geospatial AI integrates vast datasets — from satellite imagery down to street-level views — to identify complex risk patterns, which enables personalized predictions and guides precision interventions to mitigate the environmental burden of disease.","PeriodicalId":18976,"journal":{"name":"Nature Reviews Cardiology","volume":"22 10","pages":"697-699"},"PeriodicalIF":44.2,"publicationDate":"2025-08-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144850847","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}