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Cardiac memory: a phenomenon with important clinical implications. 心脏记忆：一种具有重要临床意义的现象。
IF 49.6 1区 医学
Nature Reviews Cardiology Pub Date : 2024-03-07 DOI: 10.1038/s41569-024-01008-y
Rebecca J Gilchrist
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引用次数: 0
Metabolic product of excess niacin is linked to increased risk of cardiovascular events 过量烟酸的代谢产物与心血管事件风险增加有关
IF 49.6 1区 医学
Nature Reviews Cardiology Pub Date : 2024-03-04 DOI: 10.1038/s41569-024-01005-1
Gregory B. Lim
{"title":"Metabolic product of excess niacin is linked to increased risk of cardiovascular events","authors":"Gregory B. Lim","doi":"10.1038/s41569-024-01005-1","DOIUrl":"https://doi.org/10.1038/s41569-024-01005-1","url":null,"abstract":"A metabolic product of excess niacin promotes vascular inflammation in preclinical models and is associated with increased rates of major adverse cardiovascular events in humans.","PeriodicalId":18976,"journal":{"name":"Nature Reviews Cardiology","volume":null,"pages":null},"PeriodicalIF":49.6,"publicationDate":"2024-03-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140026523","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Novel drug therapies for atrial fibrillation 治疗心房颤动的新型药物疗法
IF 49.6 1区 医学
Nature Reviews Cardiology Pub Date : 2024-02-28 DOI: 10.1038/s41569-024-01004-2
Felix Wiedmann, Constanze Schmidt
{"title":"Novel drug therapies for atrial fibrillation","authors":"Felix Wiedmann, Constanze Schmidt","doi":"10.1038/s41569-024-01004-2","DOIUrl":"https://doi.org/10.1038/s41569-024-01004-2","url":null,"abstract":"Atrial fibrillation is the most common sustained arrhythmia and imposes a substantial burden on patients and health-care providers. Clinical evidence suggests that antiarrhythmic therapy to restore and maintain sinus rhythm (rhythm control) can reduce adverse cardiovascular outcomes in patients with new-onset atrial fibrillation. As a result, a paradigm shift towards rhythm control over rate control therapy is emerging, increasing the clinical need for effective and safe antiarrhythmic drugs.","PeriodicalId":18976,"journal":{"name":"Nature Reviews Cardiology","volume":null,"pages":null},"PeriodicalIF":49.6,"publicationDate":"2024-02-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139987519","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Pulmonary vascular compliance predicts response to VAD support 肺血管顺应性可预测对 VAD 支持的反应。
IF 49.6 1区 医学
Nature Reviews Cardiology Pub Date : 2024-02-22 DOI: 10.1038/s41569-024-01002-4
Karina Huynh
{"title":"Pulmonary vascular compliance predicts response to VAD support","authors":"Karina Huynh","doi":"10.1038/s41569-024-01002-4","DOIUrl":"10.1038/s41569-024-01002-4","url":null,"abstract":"Using a porcine model of cardiogenic shock, Lamberti and colleagues develop a clinically accessible, patient-validated metric to assess pulmonary vascular compliance that can predict tolerance to left-sided ventricular assist device support.","PeriodicalId":18976,"journal":{"name":"Nature Reviews Cardiology","volume":null,"pages":null},"PeriodicalIF":49.6,"publicationDate":"2024-02-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139932128","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Heartbeat-induced pressure pulsations in cerebral arteries modulate neuronal activity 心跳引起的脑动脉压力搏动调节神经元活动
IF 49.6 1区 医学
Nature Reviews Cardiology Pub Date : 2024-02-19 DOI: 10.1038/s41569-024-00999-y
Karina Huynh
{"title":"Heartbeat-induced pressure pulsations in cerebral arteries modulate neuronal activity","authors":"Karina Huynh","doi":"10.1038/s41569-024-00999-y","DOIUrl":"10.1038/s41569-024-00999-y","url":null,"abstract":"Heartbeat-induced pressure pulsations within arterial vessels in the brain can directly stimulate central neuronal activity by activating mechanosensitive channels in subsets of neurons, according to a study published in Science.","PeriodicalId":18976,"journal":{"name":"Nature Reviews Cardiology","volume":null,"pages":null},"PeriodicalIF":49.6,"publicationDate":"2024-02-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139901736","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Weight loss from surgery or drug therapy reduces blood pressure 通过手术或药物治疗减轻体重可降低血压
IF 49.6 1区 医学
Nature Reviews Cardiology Pub Date : 2024-02-19 DOI: 10.1038/s41569-024-01000-6
Gregory B. Lim
{"title":"Weight loss from surgery or drug therapy reduces blood pressure","authors":"Gregory B. Lim","doi":"10.1038/s41569-024-01000-6","DOIUrl":"10.1038/s41569-024-01000-6","url":null,"abstract":"Two studies indicate that a reduction in body mass index as a result of either bariatric surgery or pharmacological therapy is associated with a blood pressure-lowering effect.","PeriodicalId":18976,"journal":{"name":"Nature Reviews Cardiology","volume":null,"pages":null},"PeriodicalIF":49.6,"publicationDate":"2024-02-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139901765","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
DYRK1A gene linked to heart defects in Down syndrome DYRK1A 基因与唐氏综合征的心脏缺陷有关。
IF 49.6 1区 医学
Nature Reviews Cardiology Pub Date : 2024-02-07 DOI: 10.1038/s41569-024-00995-2
Irene Fernández-Ruiz
{"title":"DYRK1A gene linked to heart defects in Down syndrome","authors":"Irene Fernández-Ruiz","doi":"10.1038/s41569-024-00995-2","DOIUrl":"10.1038/s41569-024-00995-2","url":null,"abstract":"A study shows that congenital heart defects in Down syndrome are in part caused by increased dosage of the DYRK1A gene, which lies on chromosome 21, leading to reduced proliferation and mitochondrial dysfunction in cardiomyocytes.","PeriodicalId":18976,"journal":{"name":"Nature Reviews Cardiology","volume":null,"pages":null},"PeriodicalIF":49.6,"publicationDate":"2024-02-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139702993","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Iron deficiency and supplementation in heart failure 心力衰竭患者缺铁和补充铁剂。
IF 49.6 1区 医学
Nature Reviews Cardiology Pub Date : 2024-02-07 DOI: 10.1038/s41569-024-00988-1
Samira Lakhal-Littleton, John G. F. Cleland
{"title":"Iron deficiency and supplementation in heart failure","authors":"Samira Lakhal-Littleton, John G. F. Cleland","doi":"10.1038/s41569-024-00988-1","DOIUrl":"10.1038/s41569-024-00988-1","url":null,"abstract":"Non-anaemic iron deficiency (NAID) is a strategic target in cardiovascular medicine because of its association with a range of adverse effects in various conditions. Endeavours to tackle NAID in heart failure have yielded mixed results, exposing knowledge gaps in how best to define ‘iron deficiency’ and the handling of iron therapies by the body. To address these gaps, we harness the latest understanding of the mechanisms of iron homeostasis outside the erythron and integrate clinical and preclinical lines of evidence. The emerging picture is that current definitions of iron deficiency do not assimilate the multiple influences at play in patients with heart failure and, consequently, fail to identify those with a truly unmet need for iron. Additionally, current iron supplementation therapies benefit only certain patients with heart failure, reflecting differences in the nature of the unmet need for iron and the modifying effects of anaemia and inflammation on the handling of iron therapies by the body. Building on these insights, we identify untapped opportunities in the management of NAID, including the refinement of current approaches and the development of novel strategies. Lessons learned from NAID in cardiovascular disease could ultimately translate into benefits for patients with other chronic conditions such as chronic kidney disease, chronic obstructive pulmonary disease and cancer. In this Review, Lakhal-Littleton and Cleland use the latest understanding of iron homeostasis to evaluate existing and emerging markers of iron status, describe the reciprocal relationship between iron status and heart failure, and mechanistically examine the benefits of oral and intravenous iron replacement therapies.","PeriodicalId":18976,"journal":{"name":"Nature Reviews Cardiology","volume":null,"pages":null},"PeriodicalIF":49.6,"publicationDate":"2024-02-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139702994","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Ultra-processed foods and cardiovascular disease 超加工食品与心血管疾病。
IF 49.6 1区 医学
Nature Reviews Cardiology Pub Date : 2024-01-30 DOI: 10.1038/s41569-024-00990-7
Fernanda Rauber, Renata Bertazzi Levy
{"title":"Ultra-processed foods and cardiovascular disease","authors":"Fernanda Rauber, Renata Bertazzi Levy","doi":"10.1038/s41569-024-00990-7","DOIUrl":"10.1038/s41569-024-00990-7","url":null,"abstract":"In this Comment, we critically examine the association between the increasing consumption of ultra-processed foods and their negative effect on cardiovascular health. We explore the historical evolution of food processing, the Nova food classification and the epidemiological evidence, and highlight the need for urgent public health interventions.","PeriodicalId":18976,"journal":{"name":"Nature Reviews Cardiology","volume":null,"pages":null},"PeriodicalIF":49.6,"publicationDate":"2024-01-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139642639","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Graded exercise therapy should not be recommended for patients with post-exertional malaise 对于运动后不适的患者，不建议采用分级运动疗法。
IF 49.6 1区 医学
Nature Reviews Cardiology Pub Date : 2024-01-26 DOI: 10.1038/s41569-024-00992-5
Femke Christina Ching-Chuan van Rhijn-Brouwer, Merel Hellemons, Michael Stingl, Kathryn Hoffmann, Joanne VanDerNagel, Todd E. Davenport, Eva Untersmayr, Carmen Scheibenbogen, David Putrino
{"title":"Graded exercise therapy should not be recommended for patients with post-exertional malaise","authors":"Femke Christina Ching-Chuan van Rhijn-Brouwer, Merel Hellemons, Michael Stingl, Kathryn Hoffmann, Joanne VanDerNagel, Todd E. Davenport, Eva Untersmayr, Carmen Scheibenbogen, David Putrino","doi":"10.1038/s41569-024-00992-5","DOIUrl":"10.1038/s41569-024-00992-5","url":null,"abstract":"","PeriodicalId":18976,"journal":{"name":"Nature Reviews Cardiology","volume":null,"pages":null},"PeriodicalIF":49.6,"publicationDate":"2024-01-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.nature.com/articles/s41569-024-00992-5.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139567386","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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