预测性心脏组学：将单细胞多组学转化为个性化医疗的工具

IF 44.2 1区医学 Q1 CARDIAC & CARDIOVASCULAR SYSTEMS

Nature Reviews Cardiology Pub Date : 2025-02-03 DOI:10.1038/s41569-025-01132-3

Kami Pekayvaz, Matthias Heinig, Konstantin Stark

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引用次数: 0

摘要

在这篇《临床展望》中，我们描述了心血管医学中现有的多组学研究，讨论了多组学技术在心脏病学临床翻译中的优势和潜力，并强调了三个有前景的方面：生成前所未有的细胞图谱，从综合多组学特征中鉴定出复合诊断和预后生物标志物，以及从无偏倚的综合数据集和分析中分离出潜在的治疗靶点。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

Predictive cardio-omics: translating single-cell multiomics into tools for personalized medicine

查看原文本刊更多论文

Predictive cardio-omics: translating single-cell multiomics into tools for personalized medicine

In this Clinical Outlook, we describe available multiomic studies in cardiovascular medicine, discuss the advantages and potential of multiomic techniques for clinical translation in cardiology, and highlight three promising aspects: the generation of unprecedented cellular atlases, the identification of composite diagnostic and prognostic biomarkers derived from integrative multiomic signatures, and the isolation of potential therapeutic targets from unbiased comprehensive datasets and analyses.

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来源期刊

Nature Reviews Cardiology 医学-心血管系统

CiteScore

53.10

自引率

0.60%

发文量

143

审稿时长

6-12 weeks

期刊介绍： Nature Reviews Cardiology aims to be the go-to source for reviews and commentaries in the scientific and clinical communities it serves. Focused on providing authoritative and accessible articles enriched with clear figures and tables, the journal strives to offer unparalleled service to authors, referees, and readers, maximizing the usefulness and impact of each publication. It covers a broad range of content types, including Research Highlights, Comments, News & Views, Reviews, Consensus Statements, and Perspectives, catering to practising cardiologists and cardiovascular research scientists. Authored by renowned clinicians, academics, and researchers, the content targets readers in the biological and medical sciences, ensuring accessibility across various disciplines. In-depth Reviews offer up-to-date information, while Consensus Statements provide evidence-based recommendations. Perspectives and News & Views present topical discussions and opinions, and the Research Highlights section filters primary research from cardiovascular and general medical journals. As part of the Nature Reviews portfolio, Nature Reviews Cardiology maintains high standards and a wide reach.