Nature Reviews Cardiology最新文献_第9页

Engineering extracellular vesicles for therapeutic delivery in ischaemic stroke 细胞外囊泡工程用于缺血性中风的治疗传递

IF 41.7 1区医学

Nature Reviews Cardiology Pub Date : 2025-01-14 DOI: 10.1038/s41569-025-01122-5

Lara Anne Birch

引用次数: 0

Atherosclerosis in diabetes mellitus: novel mechanisms and mechanism-based therapeutic approaches 糖尿病动脉粥样硬化：新的机制和基于机制的治疗方法

IF 49.6 1区医学

Nature Reviews Cardiology Pub Date : 2025-01-13 DOI: 10.1038/s41569-024-01115-w

Abdul Waheed Khan, Karin A. M. Jandeleit-Dahm

引用次数: 0

Cardiac optogenetics: controlling the heart with light 心脏光遗传学：用光控制心脏

IF 49.6 1区医学

Nature Reviews Cardiology Pub Date : 2025-01-13 DOI: 10.1038/s41569-025-01119-0

Sasha B. Forbes

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The rapid delayed-rectifier potassium current: a biophysical basis for cardiac repolarization and arrhythmia 快速延迟整流钾电流：心脏复极和心律失常的生物物理基础

IF 41.7 1区医学

Nature Reviews Cardiology Pub Date : 2025-01-10 DOI: 10.1038/s41569-025-01116-3

Joseph E. Carr

引用次数: 0

Phenotyping atherosclerotic plaque and perivascular adipose tissue: signalling pathways and clinical biomarkers in atherosclerosis 动脉粥样硬化斑块和血管周围脂肪组织的表型：动脉粥样硬化的信号通路和临床生物标志物

IF 49.6 1区医学

Nature Reviews Cardiology Pub Date : 2025-01-02 DOI: 10.1038/s41569-024-01110-1

Kajetan Grodecki, Jolien Geers, Jacek Kwiecinski, Andrew Lin, Leandro Slipczuk, Piotr J. Slomka, Marc R. Dweck, Nitesh Nerlekar, Michelle C. Williams, Daniel Berman, Thomas Marwick, David E. Newby, Damini Dey

{"title":"Phenotyping atherosclerotic plaque and perivascular adipose tissue: signalling pathways and clinical biomarkers in atherosclerosis","authors":"Kajetan Grodecki, Jolien Geers, Jacek Kwiecinski, Andrew Lin, Leandro Slipczuk, Piotr J. Slomka, Marc R. Dweck, Nitesh Nerlekar, Michelle C. Williams, Daniel Berman, Thomas Marwick, David E. Newby, Damini Dey","doi":"10.1038/s41569-024-01110-1","DOIUrl":"https://doi.org/10.1038/s41569-024-01110-1","url":null,"abstract":"Computed tomography coronary angiography provides a non-invasive evaluation of coronary artery disease that includes phenotyping of atherosclerotic plaques and the surrounding perivascular adipose tissue (PVAT). Image analysis techniques have been developed to quantify atherosclerotic plaque burden and morphology as well as the associated PVAT attenuation, and emerging radiomic approaches can add further contextual information. PVAT attenuation might provide a novel measure of vascular health that could be indicative of the pathogenetic processes implicated in atherosclerosis such as inflammation, fibrosis or increased vascularity. Bidirectional signalling between the coronary artery and adjacent PVAT has been hypothesized to contribute to coronary artery disease progression and provide a potential novel measure of the risk of future cardiovascular events. However, despite the development of more advanced radiomic and artificial intelligence-based algorithms, studies involving large datasets suggest that the measurement of PVAT attenuation contributes only modest additional predictive discrimination to standard cardiovascular risk scores. In this Review, we explore the pathobiology of coronary atherosclerotic plaques and PVAT, describe their phenotyping with computed tomography coronary angiography, and discuss potential future applications in clinical risk prediction and patient management.","PeriodicalId":18976,"journal":{"name":"Nature Reviews Cardiology","volume":"26 1","pages":""},"PeriodicalIF":49.6,"publicationDate":"2025-01-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142911509","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Apolipoprotein B-containing lipoproteins in atherogenesis 含载脂蛋白b的脂蛋白在动脉粥样硬化中的作用

IF 49.6 1区医学

Nature Reviews Cardiology Pub Date : 2025-01-02 DOI: 10.1038/s41569-024-01111-0

Jan Borén, Chris J. Packard, Christoph J. Binder

{"title":"Apolipoprotein B-containing lipoproteins in atherogenesis","authors":"Jan Borén, Chris J. Packard, Christoph J. Binder","doi":"10.1038/s41569-024-01111-0","DOIUrl":"https://doi.org/10.1038/s41569-024-01111-0","url":null,"abstract":"Apolipoprotein B (apoB) is the main structural protein of LDLs, triglyceride-rich lipoproteins and lipoprotein(a), and is crucial for their formation, metabolism and atherogenic properties. In this Review, we present insights into the role of apoB-containing lipoproteins in atherogenesis, with an emphasis on the mechanisms leading to plaque initiation and growth. LDL, the most abundant cholesterol-rich lipoprotein in plasma, is causally linked to atherosclerosis. LDL enters the artery wall by transcytosis and, in vulnerable regions, is retained in the subendothelial space by binding to proteoglycans via specific sites on apoB. A maladaptive response ensues. This response involves modification of LDL particles, which promotes LDL retention and the release of bioactive lipid products that trigger inflammatory responses in vascular cells, as well as adaptive immune responses. Resident and recruited macrophages take up modified LDL, leading to foam cell formation and ultimately cell death due to inadequate cellular lipid handling. Accumulation of dead cells and cholesterol crystallization are hallmarks of the necrotic core of atherosclerotic plaques. Other apoB-containing lipoproteins, although less abundant, have substantially greater atherogenicity per particle than LDL. These lipoproteins probably contribute to atherogenesis in a similar way to LDL but might also induce additional pathogenic mechanisms. Several targets for intervention to reduce the rate of atherosclerotic lesion initiation and progression have now been identified, including lowering plasma lipoprotein levels and modulating the maladaptive responses in the artery wall.","PeriodicalId":18976,"journal":{"name":"Nature Reviews Cardiology","volume":"34 1","pages":""},"PeriodicalIF":49.6,"publicationDate":"2025-01-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142911511","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Functional diversity of cardiac macrophages in health and disease 心脏巨噬细胞在健康和疾病中的功能多样性

IF 49.6 1区医学

Nature Reviews Cardiology Pub Date : 2025-01-02 DOI: 10.1038/s41569-024-01109-8

Steven Yang, Vinay Penna, Kory J. Lavine

{"title":"Functional diversity of cardiac macrophages in health and disease","authors":"Steven Yang, Vinay Penna, Kory J. Lavine","doi":"10.1038/s41569-024-01109-8","DOIUrl":"https://doi.org/10.1038/s41569-024-01109-8","url":null,"abstract":"Macrophages make up a substantial portion of the stromal compartment of the heart in health and disease. In the past decade, the origins of these cardiac macrophages have been established as two broad populations derived from either embryonic or definitive haematopoiesis and that can be distinguished by the expression of CC-motif chemokine receptor 2 (CCR2). These cardiac macrophage populations are transcriptionally distinct and have differing cell surface markers and divergent roles in cardiac homeostasis and disease. Embryonic-derived CCR2− macrophages are a tissue-resident population that participates in tissue development, repair and maintenance, whereas CCR2+ macrophages are derived from definitive haematopoiesis and contribute to inflammation and tissue damage. Studies from the past 5 years have leveraged single-cell RNA sequencing technologies to expand our understanding of cardiac macrophage diversity, particularly of the monocyte-derived macrophage populations that reside in the injured and diseased heart. Emerging technologies in spatial transcriptomics have enabled the identification of distinct disease-associated cellular neighbourhoods consisting of macrophages, other immune cells and fibroblasts, highlighting the involvement of macrophages in cell–cell communication. Together, these discoveries lend new insights into the role of specific macrophage populations in the pathogenesis of cardiac disease, which can pave the way for the identification of new therapeutic targets and the development of diagnostic tools. In this Review, we discuss the developmental origin of cardiac macrophages and describe newly identified cell states and associated cellular neighbourhoods in the steady state and injury settings. We also discuss various contributions and effector functions of cardiac macrophages in homeostasis and disease.","PeriodicalId":18976,"journal":{"name":"Nature Reviews Cardiology","volume":"29 1","pages":""},"PeriodicalIF":49.6,"publicationDate":"2025-01-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142911514","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Renal denervation for hypertension 高血压的肾去神经治疗

IF 49.6 1区医学

Nature Reviews Cardiology Pub Date : 2025-01-02 DOI: 10.1038/s41569-024-01104-z

Naomi D. L. Fisher, Ajay J. Kirtane

{"title":"Renal denervation for hypertension","authors":"Naomi D. L. Fisher, Ajay J. Kirtane","doi":"10.1038/s41569-024-01104-z","DOIUrl":"https://doi.org/10.1038/s41569-024-01104-z","url":null,"abstract":"Innovative therapies for hypertension are desperately needed given the rising prevalence and falling rates of control of hypertension despite an abundance of available medical therapies. Procedural interventions lower blood pressure without depending on adherence to medications, and endovascular renal denervation (RDN) is the interventional procedure with the best evidence base for the treatment of hypertension. After nearly two decades of study, with major refinements to devices, technique and trial design, two different systems for RDN received approval from the FDA in late 2023 for the treatment of hypertension. These decisions were based on a portfolio of sham-controlled clinical trials demonstrating efficacy and safety of both radiofrequency and ultrasound RDN in treating patients across the spectrum of hypertension, including patients with mild disease taking no or one medication as well as those with moderate and truly resistant hypertension. In this Review, we begin by summarizing the background and scope of the global problem of hypertension control and explore the evolution and mechanism of RDN. We then detail early studies and randomized clinical trials demonstrating the efficacy and safety of RDN procedures, review international statements, and provide practical guidance on patient selection and implementation of RDN, including the crucial aspects of building a hypertension team and of involving patients in shared decision-making.","PeriodicalId":18976,"journal":{"name":"Nature Reviews Cardiology","volume":"1 1","pages":""},"PeriodicalIF":49.6,"publicationDate":"2025-01-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142911510","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The spleen in ischaemic heart disease 缺血性心脏病的脾脏

IF 49.6 1区医学

Nature Reviews Cardiology Pub Date : 2025-01-02 DOI: 10.1038/s41569-024-01114-x

Gerd Heusch, Petra Kleinbongard

{"title":"The spleen in ischaemic heart disease","authors":"Gerd Heusch, Petra Kleinbongard","doi":"10.1038/s41569-024-01114-x","DOIUrl":"https://doi.org/10.1038/s41569-024-01114-x","url":null,"abstract":"Ischaemic heart disease is a consequence of coronary atherosclerosis, and atherosclerosis is a systemic inflammatory disease. The spleen releases various immune cells in temporally distinct patterns. Neutrophils, monocytes, macrophages, B cells and T cells execute innate and adaptive immune processes in the coronary atherosclerotic plaque and in the ischaemic myocardium. Prolonged inflammation contributes to ischaemic heart failure. The spleen is also a target of neuromodulation through vagal, sympathetic and sensory nerve activation. Efferent vagal activation and subsequent activation of the noradrenergic splenic nerve activate β2-adrenergic receptors on splenic T cells, which release acetylcholine that ultimately results in attenuation of cytokine secretion from splenic macrophages. Coeliac vagal nerve activation increases splenic sympathetic nerve activity and drives the release of T cells, a process that depends on placental growth factor. Activation of the vagosplenic axis protects acutely from ischaemia–reperfusion injury during auricular tragus vagal stimulation and remote ischaemic conditioning. Splenectomy abrogates all these deleterious and beneficial actions on the cardiovascular system. The aggregate effect of splenectomy in humans is a long-term increase in mortality from ischaemic heart disease. The spleen has been appreciated as an important immune organ for inflammatory processes in atherosclerosis, myocardial infarction and heart failure, whereas its complex interaction with circulating blood factors and with the autonomic and somatic nervous systems, as well as its role in cardioprotection, have emerged only in the past decade. In this Review, we describe this newly identified cardioprotective function of the spleen and highlight the potential for translating the findings to patients with ischaemic heart disease.","PeriodicalId":18976,"journal":{"name":"Nature Reviews Cardiology","volume":"38 1","pages":""},"PeriodicalIF":49.6,"publicationDate":"2025-01-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142911520","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Haematometabolism rewiring in atherosclerotic cardiovascular disease 动脉粥样硬化性心血管疾病中的血液代谢重组

IF 49.6 1区医学

Nature Reviews Cardiology Pub Date : 2025-01-02 DOI: 10.1038/s41569-024-01108-9

Laurent Yvan-Charvet, Thibault Barouillet, Coraline Borowczyk

{"title":"Haematometabolism rewiring in atherosclerotic cardiovascular disease","authors":"Laurent Yvan-Charvet, Thibault Barouillet, Coraline Borowczyk","doi":"10.1038/s41569-024-01108-9","DOIUrl":"https://doi.org/10.1038/s41569-024-01108-9","url":null,"abstract":"Atherosclerotic cardiovascular diseases are the most frequent cause of death worldwide. The clinical complications of atherosclerosis are closely linked to the haematopoietic and immune systems, which maintain homeostatic functions and vital processes in the body. The nodes linking metabolism and inflammation are receiving increasing attention because they are inextricably linked to inflammatory manifestations of non-communicable diseases, including atherosclerosis. Although metabolism and inflammation are essential to survival and involve all tissues, we still know little about how these processes influence each other. In an effort to understand these mechanisms, in this Review we explore whether and how potent cardiovascular risk factors and metabolic modifiers of atherosclerosis influence the molecular and cellular machinery of ‘haematometabolism’ (metabolic-dependent haematopoietic stem cell skewing) and ‘efferotabolism’ (metabolic-dependent efferocyte reprogramming). These changes might ultimately propagate a quantitative and qualitative drift of the macrophage supply chain and affect the clinical manifestations of atherosclerosis. Refining our understanding of the different metabolic requirements of these processes could open the possibility of developing therapeutics targeting haematometabolism that, in conjunction with improved dietary habits, help rebalance and promote efficient haematopoiesis and efferocytosis and decrease the risk of atherosclerosis complications.","PeriodicalId":18976,"journal":{"name":"Nature Reviews Cardiology","volume":"67 1","pages":""},"PeriodicalIF":49.6,"publicationDate":"2025-01-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142911512","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0