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Suture-to-scan: ultrasonography-guided induction of heart injury 从缝合到扫描：超声引导下的心脏损伤诱导
IF 41.7 1区 医学
Nature Reviews Cardiology Pub Date : 2024-06-19 DOI: 10.1038/s41569-024-01055-5
Bronwyn Berkeley, Adrian Thomson
{"title":"Suture-to-scan: ultrasonography-guided induction of heart injury","authors":"Bronwyn Berkeley, Adrian Thomson","doi":"10.1038/s41569-024-01055-5","DOIUrl":"10.1038/s41569-024-01055-5","url":null,"abstract":"In this Tools of the Trade article, Berkeley and Thomson describe the use of a minimally invasive strategy to standardize the induction of myocardial infarction in mice.","PeriodicalId":18976,"journal":{"name":"Nature Reviews Cardiology","volume":"21 9","pages":"599-599"},"PeriodicalIF":41.7,"publicationDate":"2024-06-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141425173","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Epigenetic changes in HSCs contribute to HF and comorbidities 造血干细胞的表观遗传变化导致高血脂和合并症
IF 41.7 1区 医学
Nature Reviews Cardiology Pub Date : 2024-06-12 DOI: 10.1038/s41569-024-01051-9
Karina Huynh
{"title":"Epigenetic changes in HSCs contribute to HF and comorbidities","authors":"Karina Huynh","doi":"10.1038/s41569-024-01051-9","DOIUrl":"10.1038/s41569-024-01051-9","url":null,"abstract":"Findings from a new study published in Science Immunology suggest that epigenetic changes in haematopoietic stem cells promote the production of pro-inflammatory macrophages and influence their capacity to generate protective macrophage subsets.","PeriodicalId":18976,"journal":{"name":"Nature Reviews Cardiology","volume":"21 8","pages":"522-522"},"PeriodicalIF":41.7,"publicationDate":"2024-06-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141309108","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
RNA interference lowers triglyceride levels RNA 干扰可降低甘油三酯水平。
IF 41.7 1区 医学
Nature Reviews Cardiology Pub Date : 2024-06-07 DOI: 10.1038/s41569-024-01052-8
Gregory B. Lim
{"title":"RNA interference lowers triglyceride levels","authors":"Gregory B. Lim","doi":"10.1038/s41569-024-01052-8","DOIUrl":"10.1038/s41569-024-01052-8","url":null,"abstract":"Data from the phase IIb MUIR and ARCHES-2 trials show that RNA interference approaches that target either apolipoprotein C-III or ANGPTL3 significantly reduce plasma triglyceride levels in patients with mixed hyperlipidaemia.","PeriodicalId":18976,"journal":{"name":"Nature Reviews Cardiology","volume":"21 8","pages":"522-522"},"PeriodicalIF":41.7,"publicationDate":"2024-06-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141288339","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Phase separation of protein kinase A: a new paradigm in cardiac regulation? 蛋白激酶 A 的相分离：心脏调节的新范例？
IF 41.7 1区 医学
Nature Reviews Cardiology Pub Date : 2024-06-05 DOI: 10.1038/s41569-024-01048-4
Milda Folkmanaite, Manuela Zaccolo
{"title":"Phase separation of protein kinase A: a new paradigm in cardiac regulation?","authors":"Milda Folkmanaite, Manuela Zaccolo","doi":"10.1038/s41569-024-01048-4","DOIUrl":"10.1038/s41569-024-01048-4","url":null,"abstract":"Milda Folkmanaite and Manuela Zaccolo highlight a study that demonstrates a role for phase-separated condensates of protein kinase A in buffering molecules of cAMP, to illustrate how phase separation of proteins in cardiac cells might contribute to the regulation of cardiac function.","PeriodicalId":18976,"journal":{"name":"Nature Reviews Cardiology","volume":"21 8","pages":"523-523"},"PeriodicalIF":41.7,"publicationDate":"2024-06-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141262455","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Characterization of the F8 gene: a silver lining in a dark cloud F8 基因的特征：乌云中的一线希望
IF 41.7 1区 医学
Nature Reviews Cardiology Pub Date : 2024-06-05 DOI: 10.1038/s41569-024-01050-w
Daisy Jones
{"title":"Characterization of the F8 gene: a silver lining in a dark cloud","authors":"Daisy Jones","doi":"10.1038/s41569-024-01050-w","DOIUrl":"10.1038/s41569-024-01050-w","url":null,"abstract":"Haemophilia A is caused by variants in the gene that encodes coagulation factor VIII (FVIII). Sequencing of this gene in the 1980s was the initial step in developing replacement therapy with recombinant FVIII, and thereby removing the risk of blood-borne infections from plasma-derived FVIII.","PeriodicalId":18976,"journal":{"name":"Nature Reviews Cardiology","volume":"21 10","pages":"665-665"},"PeriodicalIF":41.7,"publicationDate":"2024-06-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141251677","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Insights into endothelial metabolic heterogeneity 洞察内皮代谢异质性。
IF 41.7 1区 医学
Nature Reviews Cardiology Pub Date : 2024-06-05 DOI: 10.1038/s41569-024-01049-3
Corey McAleese
{"title":"Insights into endothelial metabolic heterogeneity","authors":"Corey McAleese","doi":"10.1038/s41569-024-01049-3","DOIUrl":"10.1038/s41569-024-01049-3","url":null,"abstract":"Corey McAleese describes the study that identified the presence of metabolic heterogeneity in endothelial cells from different tissues and discusses its relevance to our current understanding of endothelial metabolism.","PeriodicalId":18976,"journal":{"name":"Nature Reviews Cardiology","volume":"21 9","pages":"601-601"},"PeriodicalIF":41.7,"publicationDate":"2024-06-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141262454","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Metabolic remodelling in atrial fibrillation: manifestations, mechanisms and clinical implications 心房颤动的代谢重塑：表现、机制和临床意义。
IF 41.7 1区 医学
Nature Reviews Cardiology Pub Date : 2024-05-30 DOI: 10.1038/s41569-024-01038-6
David Bode, Julius Ryan D. Pronto, Gabriele G. Schiattarella, Niels Voigt
{"title":"Metabolic remodelling in atrial fibrillation: manifestations, mechanisms and clinical implications","authors":"David Bode, Julius Ryan D. Pronto, Gabriele G. Schiattarella, Niels Voigt","doi":"10.1038/s41569-024-01038-6","DOIUrl":"10.1038/s41569-024-01038-6","url":null,"abstract":"Atrial fibrillation (AF) is a continually growing health-care burden that often presents together with metabolic disorders, including diabetes mellitus and obesity. Current treatments often fall short of preventing AF and its adverse outcomes. Accumulating evidence suggests that metabolic disturbances can promote the development of AF through structural and electrophysiological remodelling, but the underlying mechanisms that predispose an individual to AF are aetiology-dependent, thus emphasizing the need for tailored therapeutic strategies to treat AF that target an individual’s metabolic profile. AF itself can induce changes in glucose, lipid and ketone metabolism, mitochondrial function and myofibrillar energetics (as part of a process referred to as ‘metabolic remodelling’), which can all contribute to atrial dysfunction. In this Review, we discuss our current understanding of AF in the setting of metabolic disorders, as well as changes in atrial metabolism that are relevant to the development of AF. We also describe the potential of available and emerging treatment strategies to target metabolic remodelling in the setting of AF and highlight key questions and challenges that need to be addressed to improve outcomes in these patients. In this Review, the authors describe the changes in metabolism that predispose individuals to developing atrial fibrillation (AF) and highlight the potential of available and emerging therapeutic strategies that target metabolic remodelling to treat AF.","PeriodicalId":18976,"journal":{"name":"Nature Reviews Cardiology","volume":"21 10","pages":"682-700"},"PeriodicalIF":41.7,"publicationDate":"2024-05-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141179443","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
A distinct platelet differentiation pathway is involved in age-related thrombocytosis 与年龄相关的血小板增多症涉及一种独特的血小板分化途径。
IF 49.6 1区 医学
Nature Reviews Cardiology Pub Date : 2024-05-29 DOI: 10.1038/s41569-024-01043-9
Karina Huynh
{"title":"A distinct platelet differentiation pathway is involved in age-related thrombocytosis","authors":"Karina Huynh","doi":"10.1038/s41569-024-01043-9","DOIUrl":"10.1038/s41569-024-01043-9","url":null,"abstract":"Poscablo and colleagues identify a distinct haematopoietic platelet differentiation pathway that is enriched in ageing mice, which results in platelets that are hyper-reactive compared with canonical platelet populations.","PeriodicalId":18976,"journal":{"name":"Nature Reviews Cardiology","volume":"21 7","pages":"438-438"},"PeriodicalIF":49.6,"publicationDate":"2024-05-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141176159","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Bariatric metabolic surgery more effective than GLP1R agonists in preventing congestive HF 在预防充血性高血压方面，减肥代谢手术比 GLP1R 激动剂更有效。
IF 49.6 1区 医学
Nature Reviews Cardiology Pub Date : 2024-05-28 DOI: 10.1038/s41569-024-01042-w
Irene Fernández-Ruiz
{"title":"Bariatric metabolic surgery more effective than GLP1R agonists in preventing congestive HF","authors":"Irene Fernández-Ruiz","doi":"10.1038/s41569-024-01042-w","DOIUrl":"10.1038/s41569-024-01042-w","url":null,"abstract":"In patients with type 2 diabetes mellitus and obesity, bariatric metabolic surgery is associated with a lower risk of the incidence of first-ever congestive heart failure than treatment with glucagon-like peptide 1 receptor agonists, according to a new study.","PeriodicalId":18976,"journal":{"name":"Nature Reviews Cardiology","volume":"21 7","pages":"438-438"},"PeriodicalIF":49.6,"publicationDate":"2024-05-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141162158","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Aficamten reduces symptoms in obstructive hypertrophic cardiomyopathy Aficamten 可减轻阻塞性肥厚型心肌病的症状。
IF 49.6 1区 医学
Nature Reviews Cardiology Pub Date : 2024-05-28 DOI: 10.1038/s41569-024-01044-8
Gregory B. Lim
{"title":"Aficamten reduces symptoms in obstructive hypertrophic cardiomyopathy","authors":"Gregory B. Lim","doi":"10.1038/s41569-024-01044-8","DOIUrl":"10.1038/s41569-024-01044-8","url":null,"abstract":"Data from the SEQUOIA-HCM trial show that aficamten, a cardiac myosin inhibitor, increases exercise capacity and improves quality of life in patients with symptomatic obstructive hypertrophic cardiomyopathy.","PeriodicalId":18976,"journal":{"name":"Nature Reviews Cardiology","volume":"21 7","pages":"437-437"},"PeriodicalIF":49.6,"publicationDate":"2024-05-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141162155","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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