Nature Reviews Cardiology最新文献_第9页

Non-coding RNAs as therapeutic targets and biomarkers in ischaemic heart disease 作为缺血性心脏病治疗靶点和生物标志物的非编码 RNA。

IF 41.7 1区医学

Nature Reviews Cardiology Pub Date : 2024-03-18 DOI: 10.1038/s41569-024-01001-5

Andrea Caporali, Maryam Anwar, Yvan Devaux, Rajesh Katare, Fabio Martelli, Prashant Kumar Srivastava, Thierry Pedrazzini, Costanza Emanueli

{"title":"Non-coding RNAs as therapeutic targets and biomarkers in ischaemic heart disease","authors":"Andrea Caporali, Maryam Anwar, Yvan Devaux, Rajesh Katare, Fabio Martelli, Prashant Kumar Srivastava, Thierry Pedrazzini, Costanza Emanueli","doi":"10.1038/s41569-024-01001-5","DOIUrl":"10.1038/s41569-024-01001-5","url":null,"abstract":"The adult heart is a complex, multicellular organ that is subjected to a series of regulatory stimuli and circuits and has poor reparative potential. Despite progress in our understanding of disease mechanisms and in the quality of health care, ischaemic heart disease remains the leading cause of death globally, owing to adverse cardiac remodelling, leading to ischaemic cardiomyopathy and heart failure. Therapeutic targets are urgently required for the protection and repair of the ischaemic heart. Moreover, personalized clinical biomarkers are necessary for clinical diagnosis, medical management and to inform the individual response to treatment. Non-coding RNAs (ncRNAs) deeply influence cardiovascular functions and contribute to communication between cells in the cardiac microenvironment and between the heart and other organs. As such, ncRNAs are candidates for translation into clinical practice. However, ncRNA biology has not yet been completely deciphered, given that classes and modes of action have emerged only in the past 5 years. In this Review, we discuss the latest discoveries from basic research on ncRNAs and highlight both the clinical value and the challenges underscoring the translation of these molecules as biomarkers and therapeutic regulators of the processes contributing to the initiation, progression and potentially the prevention or resolution of ischaemic heart disease and heart failure. Non-coding RNAs are implicated in the pathophysiology of ischaemic heart disease and heart failure. In this Review, Caporali and colleagues examine the biology of these molecules and discuss the potential of non-coding RNAs for translation to the clinic as biomarkers and therapeutics in adverse cardiac remodelling leading to ischaemic heart failure.","PeriodicalId":18976,"journal":{"name":"Nature Reviews Cardiology","volume":null,"pages":null},"PeriodicalIF":41.7,"publicationDate":"2024-03-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140158480","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Protein glycosylation in cardiovascular health and disease 心血管健康和疾病中的蛋白质糖基化

IF 41.7 1区医学

Nature Reviews Cardiology Pub Date : 2024-03-18 DOI: 10.1038/s41569-024-00998-z

John C. Chatham, Rakesh P. Patel

{"title":"Protein glycosylation in cardiovascular health and disease","authors":"John C. Chatham, Rakesh P. Patel","doi":"10.1038/s41569-024-00998-z","DOIUrl":"10.1038/s41569-024-00998-z","url":null,"abstract":"Protein glycosylation, which involves the attachment of carbohydrates to proteins, is one of the most abundant protein co-translational and post-translational modifications. Advances in technology have substantially increased our knowledge of the biosynthetic pathways involved in protein glycosylation, as well as how changes in glycosylation can affect cell function. In addition, our understanding of the role of protein glycosylation in disease processes is growing, particularly in the context of immune system function, infectious diseases, neurodegeneration and cancer. Several decades ago, cell surface glycoproteins were found to have an important role in regulating ion transport across the cardiac sarcolemma. However, with very few exceptions, our understanding of how changes in protein glycosylation influence cardiovascular (patho)physiology remains remarkably limited. Therefore, in this Review, we aim to provide an overview of N-linked and O-linked protein glycosylation, including intracellular O-linked N-acetylglucosamine protein modification. We discuss our current understanding of how all forms of protein glycosylation contribute to normal cardiovascular function and their roles in cardiovascular disease. Finally, we highlight potential gaps in our knowledge about the effects of protein glycosylation on the heart and vascular system, highlighting areas for future research. Protein glycosylation is vital to the regulation of cell function, and changes in this post-translational modification underlie many disease processes. In this Review, Chatham and Patel discuss how protein glycosylation contributes to normal cardiovascular function and its role in cardiovascular disease, identifying important knowledge gaps and areas for future research.","PeriodicalId":18976,"journal":{"name":"Nature Reviews Cardiology","volume":null,"pages":null},"PeriodicalIF":41.7,"publicationDate":"2024-03-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140146029","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Presence of microplastics in carotid plaques linked to cardiovascular events. 颈动脉斑块中的微塑料与心血管事件有关。

IF 49.6 1区医学

Nature Reviews Cardiology Pub Date : 2024-03-18 DOI: 10.1038/s41569-024-01015-z

Karina Huynh

引用次数: 0

Long-read sequencing provides insights into genetic influence 长读数测序有助于深入了解基因的影响。

IF 49.6 1区医学

Nature Reviews Cardiology Pub Date : 2024-03-18 DOI: 10.1038/s41569-024-01012-2

Cara Trivett

引用次数: 0

Imaging cAMP nanodomains in human iPSC-derived cardiomyocytes 成像人类 iPSC 衍生心肌细胞中的 cAMP 纳米域

IF 49.6 1区医学

Nature Reviews Cardiology Pub Date : 2024-03-15 DOI: 10.1038/s41569-024-01013-1

Camille Charrière

引用次数: 0

Novel cardiovascular therapeutics and the risk of financial toxicity 新型心血管疗法和经济毒性风险。

IF 49.6 1区医学

Nature Reviews Cardiology Pub Date : 2024-03-14 DOI: 10.1038/s41569-024-01010-4

Alexander H. Gunn, Akshay Pendyal

引用次数: 0

Modelling pre-eclampsia and its cardiovascular effects. 模拟先兆子痫及其对心血管的影响。

IF 49.6 1区医学

Nature Reviews Cardiology Pub Date : 2024-03-13 DOI: 10.1038/s41569-024-01006-0

Sol Olivera, Delyth Graham

引用次数: 0

An epigenome editing approach induces durable silencing of Pcsk9 表观基因组编辑方法诱导 Pcsk9 持久沉默

IF 49.6 1区医学

Nature Reviews Cardiology Pub Date : 2024-03-13 DOI: 10.1038/s41569-024-01011-3

Irene Fernández-Ruiz

引用次数: 0

Tackling inflammation in atherosclerosis 解决动脉粥样硬化中的炎症问题。

IF 49.6 1区医学

Nature Reviews Cardiology Pub Date : 2024-03-12 DOI: 10.1038/s41569-024-01007-z

Mohsen Shoaran, Pasquale Maffia

引用次数: 0

IF 49.6 1区医学

Nature Reviews Cardiology Pub Date : 2024-03-08 DOI: 10.1038/s41569-024-00996-1

Janice Y. Chyou, Hailun Qin, Javed Butler, Adriaan A. Voors, Carolyn S. P. Lam

{"title":"Sex-related similarities and differences in responses to heart failure therapies","authors":"Janice Y. Chyou, Hailun Qin, Javed Butler, Adriaan A. Voors, Carolyn S. P. Lam","doi":"10.1038/s41569-024-00996-1","DOIUrl":"10.1038/s41569-024-00996-1","url":null,"abstract":"Although sex-related differences in the epidemiology, risk factors, clinical characteristics and outcomes of heart failure are well known, investigations in the past decade have shed light on an often overlooked aspect of heart failure: the influence of sex on treatment response. Sex-related differences in anatomy, physiology, pharmacokinetics, pharmacodynamics and psychosocial factors might influence the response to pharmacological agents, device therapy and cardiac rehabilitation in patients with heart failure. In this Review, we discuss the similarities between men and women in their response to heart failure therapies, as well as the sex-related differences in treatment benefits, dose–response relationships, and tolerability and safety of guideline-directed medical therapy, device therapy and cardiac rehabilitation. We provide insights into the unique challenges faced by men and women with heart failure, highlight potential avenues for tailored therapeutic approaches and call for sex-specific evaluation of treatment efficacy and safety in future research. In this Review, Lam and colleagues evaluate the current literature on sex-related differences in treatment responses in patients with heart failure and highlight potential approaches for tailored therapies and the need for sex-specific evaluation of treatment efficacy and safety in future research.","PeriodicalId":18976,"journal":{"name":"Nature Reviews Cardiology","volume":null,"pages":null},"PeriodicalIF":49.6,"publicationDate":"2024-03-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140064287","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0