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No benefit of β-blockers after myocardial infarction with preserved ejection fraction 射血分数保留的心肌梗死后使用β-受体阻滞剂无益
IF 49.6 1区 医学
Nature Reviews Cardiology Pub Date : 2024-04-22 DOI: 10.1038/s41569-024-01030-0
Gregory B. Lim
{"title":"No benefit of β-blockers after myocardial infarction with preserved ejection fraction","authors":"Gregory B. Lim","doi":"10.1038/s41569-024-01030-0","DOIUrl":"10.1038/s41569-024-01030-0","url":null,"abstract":"In the REDUCE-AMI trial, the use of β-blockers in patients with acute myocardial infarction (MI) who have undergone early coronary angiography and have a preserved left ventricular ejection fraction did not reduce the risk of death or new MI compared with no β-blocker use.","PeriodicalId":18976,"journal":{"name":"Nature Reviews Cardiology","volume":"21 6","pages":"354-354"},"PeriodicalIF":49.6,"publicationDate":"2024-04-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140637691","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Self-expanding valves more beneficial than balloon-expandable valves in patients with a small aortic annulus 在主动脉瓣环较小的患者中，自扩张瓣膜比球囊扩张瓣膜更有益
IF 49.6 1区 医学
Nature Reviews Cardiology Pub Date : 2024-04-19 DOI: 10.1038/s41569-024-01027-9
Karina Huynh
{"title":"Self-expanding valves more beneficial than balloon-expandable valves in patients with a small aortic annulus","authors":"Karina Huynh","doi":"10.1038/s41569-024-01027-9","DOIUrl":"10.1038/s41569-024-01027-9","url":null,"abstract":"In patients with symptomatic aortic stenosis and a small aortic annulus, a self-expanding valve has similar rates of clinical outcomes at 1 year and lower rates of bioprosthetic dysfunction compared with a balloon-expandable valve.","PeriodicalId":18976,"journal":{"name":"Nature Reviews Cardiology","volume":"21 6","pages":"356-356"},"PeriodicalIF":49.6,"publicationDate":"2024-04-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140621580","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Gut bacteria can break down cholesterol 肠道细菌能分解胆固醇
IF 49.6 1区 医学
Nature Reviews Cardiology Pub Date : 2024-04-16 DOI: 10.1038/s41569-024-01026-w
Irene Fernández-Ruiz
{"title":"Gut bacteria can break down cholesterol","authors":"Irene Fernández-Ruiz","doi":"10.1038/s41569-024-01026-w","DOIUrl":"10.1038/s41569-024-01026-w","url":null,"abstract":"A new study identifies a group of gut bacteria that can metabolize cholesterol and are associated with lower plasma cholesterol levels.","PeriodicalId":18976,"journal":{"name":"Nature Reviews Cardiology","volume":"21 6","pages":"357-357"},"PeriodicalIF":49.6,"publicationDate":"2024-04-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140556643","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Canonical and non-canonical roles of complement in atherosclerosis 补体在动脉粥样硬化中的规范和非规范作用
IF 41.7 1区 医学
Nature Reviews Cardiology Pub Date : 2024-04-10 DOI: 10.1038/s41569-024-01016-y
Pasquale Maffia, Claudio Mauro, Ayden Case, Claudia Kemper
{"title":"Canonical and non-canonical roles of complement in atherosclerosis","authors":"Pasquale Maffia, Claudio Mauro, Ayden Case, Claudia Kemper","doi":"10.1038/s41569-024-01016-y","DOIUrl":"10.1038/s41569-024-01016-y","url":null,"abstract":"Cardiovascular diseases are the leading cause of death globally, and atherosclerosis is the major contributor to the development and progression of cardiovascular diseases. Immune responses have a central role in the pathogenesis of atherosclerosis, with the complement system being an acknowledged contributor. Chronic activation of liver-derived and serum-circulating canonical complement sustains endothelial inflammation and innate immune cell activation, and deposition of complement activation fragments on inflamed endothelial cells is a hallmark of atherosclerotic plaques. However, increasing evidence indicates that liver-independent, cell-autonomous and non-canonical complement activities are underappreciated contributors to atherosclerosis. Furthermore, complement activation can also have atheroprotective properties. These specific detrimental or beneficial contributions of the complement system to the pathogenesis of atherosclerosis are dictated by the location of complement activation and engagement of its canonical versus non-canonical functions in a temporal fashion during atherosclerosis progression. In this Review, we summarize the classical and the emerging non-classical roles of the complement system in the pathogenesis of atherosclerosis and discuss potential strategies for therapeutic modulation of complement for the prevention and treatment of atherosclerotic cardiovascular disease. In this Review, Kemper and colleagues discuss the canonical and non-canonical roles of the complement system in the pathogenesis of atherosclerosis and discuss potential new therapeutic strategies targeting the complement system for the prevention and treatment of atherosclerotic cardiovascular disease.","PeriodicalId":18976,"journal":{"name":"Nature Reviews Cardiology","volume":"21 11","pages":"743-761"},"PeriodicalIF":41.7,"publicationDate":"2024-04-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.nature.com/articles/s41569-024-01016-y.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140541372","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Cardiovascular disease and cancer: shared risk factors and mechanisms 心血管疾病和癌症：共同的风险因素和机制
IF 41.7 1区 医学
Nature Reviews Cardiology Pub Date : 2024-04-10 DOI: 10.1038/s41569-024-01017-x
Nicholas S. Wilcox, Uri Amit, Jacob B. Reibel, Eva Berlin, Kendyl Howell, Bonnie Ky
{"title":"Cardiovascular disease and cancer: shared risk factors and mechanisms","authors":"Nicholas S. Wilcox, Uri Amit, Jacob B. Reibel, Eva Berlin, Kendyl Howell, Bonnie Ky","doi":"10.1038/s41569-024-01017-x","DOIUrl":"10.1038/s41569-024-01017-x","url":null,"abstract":"Cardiovascular disease (CVD) and cancer are among the leading causes of morbidity and mortality globally, and these conditions are increasingly recognized to be fundamentally interconnected. In this Review, we present the current epidemiological data for each of the modifiable risk factors shared by the two diseases, including hypertension, hyperlipidaemia, diabetes mellitus, obesity, smoking, diet, physical activity and the social determinants of health. We then review the epidemiological data demonstrating the increased risk of CVD in patients with cancer, as well as the increased risk of cancer in patients with CVD. We also discuss the shared mechanisms implicated in the development of these conditions, highlighting their inherent bidirectional relationship. We conclude with a perspective on future research directions for the field of cardio-oncology to advance the care of patients with CVD and cancer. Patients with cardiovascular disease (CVD) have an increased risk of cancer, and patients with cancer have an increased risk of CVD. In this Review, the authors discuss the shared modifiable risk factors and the shared pathophysiological mechanisms underlying the bidirectional relationship between these two prevalent diseases.","PeriodicalId":18976,"journal":{"name":"Nature Reviews Cardiology","volume":"21 9","pages":"617-631"},"PeriodicalIF":41.7,"publicationDate":"2024-04-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140541402","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Uncovering atherosclerotic cardiovascular disease by PET imaging 通过 PET 成像发现动脉粥样硬化性心血管疾病
IF 41.7 1区 医学
Nature Reviews Cardiology Pub Date : 2024-04-04 DOI: 10.1038/s41569-024-01009-x
Alexander Maier, Abraham J. P. Teunissen, Sheqouia A. Nauta, Esther Lutgens, Zahi A. Fayad, Mandy M. T. van Leent
{"title":"Uncovering atherosclerotic cardiovascular disease by PET imaging","authors":"Alexander Maier, Abraham J. P. Teunissen, Sheqouia A. Nauta, Esther Lutgens, Zahi A. Fayad, Mandy M. T. van Leent","doi":"10.1038/s41569-024-01009-x","DOIUrl":"10.1038/s41569-024-01009-x","url":null,"abstract":"Assessing atherosclerosis severity is essential for precise patient stratification. Specifically, there is a need to identify patients with residual inflammation because these patients remain at high risk of cardiovascular events despite optimal management of cardiovascular risk factors. Molecular imaging techniques, such as PET, can have an essential role in this context. PET imaging can indicate tissue-based disease status, detect early molecular changes and provide whole-body information. Advances in molecular biology and bioinformatics continue to help to decipher the complex pathogenesis of atherosclerosis and inform the development of imaging tracers. Concomitant advances in tracer synthesis methods and PET imaging technology provide future possibilities for atherosclerosis imaging. In this Review, we summarize the latest developments in PET imaging techniques and technologies for assessment of atherosclerotic cardiovascular disease and discuss the relationship between imaging readouts and transcriptomics-based plaque phenotyping. In this Review, van Leent and colleagues provide an overview of current PET imaging approaches for assessment of atherosclerotic cardiovascular disease, as well as of whole-body PET applications; discuss the link between imaging readouts and atherosclerotic plaque pathology; and highlight promising developments in PET systems and radiotracer synthesis.","PeriodicalId":18976,"journal":{"name":"Nature Reviews Cardiology","volume":"21 9","pages":"632-651"},"PeriodicalIF":41.7,"publicationDate":"2024-04-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140349569","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Alain Cribier (1945–2024) 阿兰-克里比耶（1945-2024）
IF 49.6 1区 医学
Nature Reviews Cardiology Pub Date : 2024-04-03 DOI: 10.1038/s41569-024-01019-9
Martine Gilard, William Wijns
{"title":"Alain Cribier (1945–2024)","authors":"Martine Gilard, William Wijns","doi":"10.1038/s41569-024-01019-9","DOIUrl":"10.1038/s41569-024-01019-9","url":null,"abstract":"Gilard and Wijns reflect on the life of Alain Cribier, who revolutionized the management of patients with valvular disease.","PeriodicalId":18976,"journal":{"name":"Nature Reviews Cardiology","volume":"21 6","pages":"351-351"},"PeriodicalIF":49.6,"publicationDate":"2024-04-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.nature.com/articles/s41569-024-01019-9.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140343390","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Small extracellular vesicles from the infarcted heart can promote tumour growth 梗死心脏中的细胞外小泡可促进肿瘤生长
IF 49.6 1区 医学
Nature Reviews Cardiology Pub Date : 2024-04-02 DOI: 10.1038/s41569-024-01022-0
Karina Huynh
{"title":"Small extracellular vesicles from the infarcted heart can promote tumour growth","authors":"Karina Huynh","doi":"10.1038/s41569-024-01022-0","DOIUrl":"10.1038/s41569-024-01022-0","url":null,"abstract":"After myocardial infarction, the heart secretes small extracellular vesicles with pro-neoplastic properties that can accelerate tumour growth when taken up by cancer cells.","PeriodicalId":18976,"journal":{"name":"Nature Reviews Cardiology","volume":"21 6","pages":"358-358"},"PeriodicalIF":49.6,"publicationDate":"2024-04-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140346303","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Interventional thrombus modification in STEMI STEMI 中的介入血栓改造
IF 49.6 1区 医学
Nature Reviews Cardiology Pub Date : 2024-04-02 DOI: 10.1038/s41569-024-01020-2
Jason L. Walsh, Rafail A. Kotronias, Adrian P. Banning, Giovanni Luigi De Maria
{"title":"Interventional thrombus modification in STEMI","authors":"Jason L. Walsh, Rafail A. Kotronias, Adrian P. Banning, Giovanni Luigi De Maria","doi":"10.1038/s41569-024-01020-2","DOIUrl":"10.1038/s41569-024-01020-2","url":null,"abstract":"In ST-segment elevation myocardial infarction, the role of interventional modification of thrombi in the coronary arteries before stenting is controversial. However, innovations in stroke intervention have sparked renewed interest in thrombus modification approaches. We discuss current and emerging techniques to extract or disperse thrombi, aiming to reduce downstream embolization, microvascular obstruction and myocardial injury.","PeriodicalId":18976,"journal":{"name":"Nature Reviews Cardiology","volume":"21 7","pages":"435-436"},"PeriodicalIF":49.6,"publicationDate":"2024-04-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140343409","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
A newly identified gut hormone suppresses cholesterol production in the liver 一种新发现的肠道激素能抑制肝脏中胆固醇的生成。
IF 49.6 1区 医学
Nature Reviews Cardiology Pub Date : 2024-03-28 DOI: 10.1038/s41569-024-01021-1
Irene Fernández-Ruiz
{"title":"A newly identified gut hormone suppresses cholesterol production in the liver","authors":"Irene Fernández-Ruiz","doi":"10.1038/s41569-024-01021-1","DOIUrl":"10.1038/s41569-024-01021-1","url":null,"abstract":"A new study identifies a hormone that is secreted by the gut in response to cholesterol absorption and can inhibit cholesterol synthesis in the liver, which prevents an increase in circulating cholesterol levels.","PeriodicalId":18976,"journal":{"name":"Nature Reviews Cardiology","volume":"21 6","pages":"358-358"},"PeriodicalIF":49.6,"publicationDate":"2024-03-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140318699","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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