Nature Reviews Cardiology最新文献_第8页

Stress and cardiovascular disease: an update 压力与心血管疾病：最新进展

IF 41.7 1区医学

Nature Reviews Cardiology Pub Date : 2024-05-02 DOI: 10.1038/s41569-024-01024-y

Viola Vaccarino, J. Douglas Bremner

{"title":"Stress and cardiovascular disease: an update","authors":"Viola Vaccarino, J. Douglas Bremner","doi":"10.1038/s41569-024-01024-y","DOIUrl":"10.1038/s41569-024-01024-y","url":null,"abstract":"Psychological stress is generally accepted to be associated with an increased risk of cardiovascular disease (CVD), but results have varied in terms of how stress is measured and the strength of the association. Additionally, the mechanisms and potential causal links have remained speculative despite decades of research. The physiological responses to stress are well characterized, but their contribution to the development and progression of CVD has received little attention in empirical studies. Evidence suggests that physiological responses to stress have a fundamental role in the risk of CVD and that haemodynamic, vascular and immune perturbations triggered by stress are especially implicated. Stress response physiology is regulated by the corticolimbic regions of the brain, which have outputs to the autonomic nervous system. Variation in these regulatory pathways might explain interindividual differences in vulnerability to stress. Dynamic perturbations in autonomic, immune and vascular functions are probably also implicated as CVD risk mechanisms of chronic, recurring and cumulative stressful exposures, but more data are needed from prospective studies and from assessments in real-life situations. Psychological assessment remains insufficiently recognized in clinical care and prevention. Although stress-reduction interventions might mitigate perceived stress levels and potentially reduce cardiovascular risk, more data from randomized trials are needed. Physiological responses to stress are thought to increase the risk of cardiovascular disease via haemodynamic, vascular and immune perturbations. In this Review, Vaccarino and Bremner focus on issues with the measurement of psychological stress and the underlying pathobiology connecting stress to the risk of cardiovascular disease.","PeriodicalId":18976,"journal":{"name":"Nature Reviews Cardiology","volume":"21 9","pages":"603-616"},"PeriodicalIF":41.7,"publicationDate":"2024-05-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140819523","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Screening for Helicobacter pylori infection in patients with cardiovascular and gastrointestinal disease 筛查心血管和胃肠道疾病患者的幽门螺旋杆菌感染。

IF 41.7 1区医学

Nature Reviews Cardiology Pub Date : 2024-05-02 DOI: 10.1038/s41569-024-01028-8

Jonatan Wärme, Martin O. Sundqvist, Stefan James, Robin Hofmann

引用次数: 0

Reply to ‘Screening for Helicobacter pylori infection in patients with cardiovascular and gastrointestinal disease’ 对 "心血管和胃肠道疾病患者幽门螺杆菌感染筛查 "的答复

IF 41.7 1区医学

Nature Reviews Cardiology Pub Date : 2024-05-02 DOI: 10.1038/s41569-024-01029-7

Azita H. Talasaz, Behnood Bikdeli

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Periodontal treatment reduces AF recurrence 牙周治疗可减少房颤复发

IF 49.6 1区医学

Nature Reviews Cardiology Pub Date : 2024-04-25 DOI: 10.1038/s41569-024-01036-8

Gregory B. Lim

引用次数: 0

Targeting immune cell recruitment in atherosclerosis 以动脉粥样硬化中的免疫细胞招募为目标

IF 41.7 1区医学

Nature Reviews Cardiology Pub Date : 2024-04-25 DOI: 10.1038/s41569-024-01023-z

Yvonne Döring, Emiel P. C. van der Vorst, Christian Weber

{"title":"Targeting immune cell recruitment in atherosclerosis","authors":"Yvonne Döring, Emiel P. C. van der Vorst, Christian Weber","doi":"10.1038/s41569-024-01023-z","DOIUrl":"10.1038/s41569-024-01023-z","url":null,"abstract":"Atherosclerosis is the primary underlying cause of myocardial infarction and stroke. Atherosclerotic cardiovascular disease is characterized by a chronic inflammatory reaction in medium-to-large-sized arteries, with its onset and perpetuation driven by leukocytes infiltrating the subendothelial space. Activation of endothelial cells triggered by hyperlipidaemia and lipoprotein retention in the arterial intima initiates the accumulation of pro-inflammatory leukocytes in the arterial wall, fostering the progression of atherosclerosis. This inflammatory response is coordinated by an array of soluble mediators, namely cytokines and chemokines, that amplify inflammation both locally and systemically and are complemented by tissue-specific molecules that regulate the homing, adhesion and transmigration of leukocytes. Despite abundant evidence from mouse models, only a few therapies targeting leukocytes in atherosclerosis have been assessed in humans. The major challenges for the clinical translation of these therapies include the lack of tissue specificity and insufficient selectivity of inhibition strategies. In this Review, we discuss the latest research on receptor–ligand pairs and interactors that regulate leukocyte influx into the inflamed artery wall, primarily focusing on studies that used pharmacological interventions. We also discuss mechanisms that promote the resolution of inflammation and highlight how major findings from these research areas hold promise as potential therapeutic strategies for atherosclerotic cardiovascular disease. In this Review, the authors discuss the receptors, ligands and interactors that regulate immune cell recruitment in atherosclerosis, describe mechanisms that promote the resolution of inflammation in atherosclerotic lesions, and highlight potential strategies to target these pathways for the treatment of atherosclerotic cardiovascular disease.","PeriodicalId":18976,"journal":{"name":"Nature Reviews Cardiology","volume":"21 11","pages":"824-840"},"PeriodicalIF":41.7,"publicationDate":"2024-04-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.nature.com/articles/s41569-024-01023-z.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140648752","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

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The coronary sinus reducer improves angina symptoms in patients with stable CAD 冠状窦减压器可改善稳定型 CAD 患者的心绞痛症状

IF 49.6 1区医学

Nature Reviews Cardiology Pub Date : 2024-04-25 DOI: 10.1038/s41569-024-01033-x

Karina Huynh

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RNA-based therapies targeting APOC3 lower triglyceride levels in patients with hypertriglyceridaemia 针对 APOC3 的 RNA 型疗法可降低高甘油三酯血症患者的甘油三酯水平

IF 49.6 1区医学

Nature Reviews Cardiology Pub Date : 2024-04-23 DOI: 10.1038/s41569-024-01034-w

Karina Huynh

引用次数: 0

Benefits of ninerafaxstat in non-obstructive hypertrophic cardiomyopathy 尼那非司他对非阻塞性肥厚型心肌病的益处

IF 49.6 1区医学

Nature Reviews Cardiology Pub Date : 2024-04-23 DOI: 10.1038/s41569-024-01032-y

Gregory B. Lim

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Strategies for the delivery of sex-based equity in cardiovascular clinical trials 在心血管临床试验中实现性别公平的策略

IF 49.6 1区医学

Nature Reviews Cardiology Pub Date : 2024-04-23 DOI: 10.1038/s41569-024-01025-x

Julie Sanders, Tim Clayton, Stacey Matthews, Sarah Murray, Lynn Laidlaw, Richard Evans, Rochelle Wynne

引用次数: 0

Heart pump increases survival in STEMI-related cardiogenic shock 心脏泵可提高 STEMI 相关性心源性休克患者的存活率

IF 49.6 1区医学

Nature Reviews Cardiology Pub Date : 2024-04-23 DOI: 10.1038/s41569-024-01035-9

Jennifer Harman

引用次数: 0