Nature Reviews Cardiology最新文献

{"title":"Charting the future of cardiology with large language model artificial intelligence","authors":"Ramsey M. Wehbe","doi":"10.1038/s41569-024-01105-y","DOIUrl":"10.1038/s41569-024-01105-y","url":null,"abstract":"Large language models represent a transformative leap in artificial intelligence and natural language processing, offering exciting potential across cardiology, from clinical care to education and research. However, several crucial challenges limit the practical implementation of large language models in cardiology. Interdisciplinary research is imperative to overcome these barriers.","PeriodicalId":18976,"journal":{"name":"Nature Reviews Cardiology","volume":"22 3","pages":"143-144"},"PeriodicalIF":41.7,"publicationDate":"2024-11-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142670677","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Trade-offs between vessel-based and substrate-based nomenclatures for coronary heart diseases","authors":"Robert A. Byrne, Adnan Kastrati","doi":"10.1038/s41569-024-01099-7","DOIUrl":"10.1038/s41569-024-01099-7","url":null,"abstract":"Debate exists regarding the best terminology for common presentations of heart diseases caused by epicardial and/or microvascular coronary artery disease with or without myocardial ischaemia. In this Comment, we discuss the pros and cons of a new proposal to replace the vessel-based nomenclature of acute and chronic coronary syndromes with the myocardial-oriented nomenclature of acute and non-acute myocardial ischaemic syndromes.","PeriodicalId":18976,"journal":{"name":"Nature Reviews Cardiology","volume":"22 2","pages":"65-66"},"PeriodicalIF":41.7,"publicationDate":"2024-11-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142624329","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Improving English proficiency for scientific communication by non-fluent speakers","authors":"Dong Zhao, Maria Rubini","doi":"10.1038/s41569-024-01102-1","DOIUrl":"10.1038/s41569-024-01102-1","url":null,"abstract":"English has long been the dominant language in scientific communication. Although having a universal language for scientific communication is beneficial, this standard imposes a considerable barrier for researchers who do not speak English fluently. However, the current generation of scientists is overcoming this barrier through the use of artificial intelligence-based language tools.","PeriodicalId":18976,"journal":{"name":"Nature Reviews Cardiology","volume":"22 3","pages":"141-142"},"PeriodicalIF":41.7,"publicationDate":"2024-11-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142624279","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Monocytes migrate to the brain after MI to promote deep sleep to aid cardiac healing","authors":"Irene Fernández-Ruiz","doi":"10.1038/s41569-024-01106-x","DOIUrl":"10.1038/s41569-024-01106-x","url":null,"abstract":"After myocardial infarction, monocytes are actively recruited to the brain to augment sleep power and abundance, which in turn helps to limit cardiac inflammation and promotes recovery.","PeriodicalId":18976,"journal":{"name":"Nature Reviews Cardiology","volume":"22 1","pages":"4-4"},"PeriodicalIF":41.7,"publicationDate":"2024-11-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142624324","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cardiodermatology: the heart of the connection between the skin and cardiovascular disease","authors":"Joel M. Gelfand, William B. Song, Sinéad M. Langan, Michael S. Garshick","doi":"10.1038/s41569-024-01097-9","DOIUrl":"https://doi.org/10.1038/s41569-024-01097-9","url":null,"abstract":"<p>The skin and cardiovascular systems are connected in unique and meaningful ways, and many diseases conventionally considered as being limited to one organ system are more closely related than previously believed. Major cardiovascular diseases and phenomena such as infective endocarditis, congestive heart failure, Kawasaki disease and thromboembolism are associated with specific skin findings, and advances in genetics, immunology and clinical epidemiology show that inflammatory dermatological diseases, such as psoriasis, have serious cardiovascular and cardiometabolic consequences. Additionally, commonly used cardiovascular therapies, such as antihypertensive medications, are associated with important cutaneous adverse effects, including photosensitivity, photocarcinogenesis and eczematous skin reactions. Moreover, systemic dermatological therapies, including retinoids, Janus kinase inhibitors and biologics, can alter the risk of cardiovascular and cardiometabolic diseases. In this Review on cardiodermatology, we provide interdisciplinary insights from dermatology and cardiology that will be of practical use to both cardiologists and generalists who manage cardiovascular and cardiometabolic diseases in patients with dermatological findings or histories. We discuss specific skin findings associated with cardiovascular diseases to aid in diagnosis; important cutaneous adverse effects of common cardiovascular therapies, for the purpose of treatment monitoring; and the effect of dermatological diseases and dermatological treatment on cardiovascular risk.</p>","PeriodicalId":18976,"journal":{"name":"Nature Reviews Cardiology","volume":"12 1","pages":""},"PeriodicalIF":49.6,"publicationDate":"2024-11-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142609970","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Our revered and mysterious heart","authors":"Philip Kilner","doi":"10.1038/s41569-024-01096-w","DOIUrl":"10.1038/s41569-024-01096-w","url":null,"abstract":"A review of Robin Choudhury’s book The Beating Heart: The Art &amp; Science of Our Most Vital Organ, which explores depictions and perceptions of the heart across millennia.","PeriodicalId":18976,"journal":{"name":"Nature Reviews Cardiology","volume":"22 1","pages":"1-2"},"PeriodicalIF":41.7,"publicationDate":"2024-11-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142589099","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Nanomedicine-based strategies for the treatment of vein graft disease","authors":"Zhuoming Zhou,&nbsp;Wei Chen,&nbsp;Yihai Cao,&nbsp;Reza Abdi,&nbsp;Wei Tao","doi":"10.1038/s41569-024-01094-y","DOIUrl":"10.1038/s41569-024-01094-y","url":null,"abstract":"Autologous saphenous veins are the most frequently used conduits for coronary and peripheral artery bypass grafting. However, vein graft failure rates of 40–50% within 10 years of the implantation lead to poor long-term outcomes after bypass surgery. Currently, only a few therapeutic approaches for vein graft disease have been successfully translated into clinical practice. Building on the past two decades of advanced understanding of vein graft biology and the pathophysiological mechanisms underlying vein graft disease, nanomedicine-based strategies offer promising opportunities to address this important unmet clinical need. In this Review, we provide deep insight into the latest developments in the rational design and applications of nanoparticles that have the potential to target specific cells during various pathophysiological stages of vein graft disease, including early endothelial dysfunction, intermediate intimal hyperplasia and late-stage accelerated atherosclerosis. Additionally, we underscore the convergence of nanofabricated biomaterials, with a particular focus on hydrogels, external graft support devices and cell-based therapies, alongside bypass surgery to improve local delivery efficiency and therapeutic efficacy. Finally, we provide a specific discussion on the considerations, challenges and novel perspectives for the future clinical translation of nanomedicine for the treatment of vein graft disease. In this Review, Tao and colleagues discuss the design and applications of nanoparticles and nanofabricated biomaterials, such as hydrogels, external graft support devices and cell-based therapies, for the treatment of vein graft disease and highlight the potential of using these nanofabricated biomaterials alongside bypass surgery to improve local delivery efficiency and therapeutic efficacy.","PeriodicalId":18976,"journal":{"name":"Nature Reviews Cardiology","volume":"22 4","pages":"255-272"},"PeriodicalIF":41.7,"publicationDate":"2024-11-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142580063","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Environmental sustainability in cardiovascular practice: current challenges and future directions","authors":"Sanjay Rajagopalan,&nbsp;Scott McAlister,&nbsp;Jason Jay,&nbsp;Richard D. Pham,&nbsp;Robert D. Brook,&nbsp;Khurram Nasir,&nbsp;Mark. J. Nieuwenhuijsen,&nbsp;Philip Landrigan,&nbsp;Allegra Wiesler,&nbsp;Christina Vernon Sanborn,&nbsp;Justin R. Carron,&nbsp;Kara Hammond Brooks,&nbsp;Aruni Bhatnagar,&nbsp;Sadeer Al-Kindi","doi":"10.1038/s41569-024-01077-z","DOIUrl":"10.1038/s41569-024-01077-z","url":null,"abstract":"Cardiovascular disease is the leading cause of morbidity and mortality worldwide, with a substantial amount of health-care resources targeted towards its diagnosis and management. Environmental sustainability in cardiovascular care can have an important role in reducing greenhouse gas emissions and pollution and could be beneficial for improving health metrics and societal well-being and minimizing the cost of health care. In this Review, we discuss the motivations and frameworks for sustainable cardiovascular care with an emphasis on the reduction of the climate-related and environmental effects of cardiovascular care. We also provide an overview of greenhouse gas emissions related to the provision of health care, including their measurement and quantification, carbon accounting, carbon disclosures and climate effects. The principles of life-cycle assessment, waste prevention and circular economics in health care are discussed, and the emissions associated with various sectors of cardiovascular care as well as the rationale for prevention as a powerful approach to reduce these emissions are presented. Finally, we highlight the challenges in environmental sustainability and future directions as applicable to cardiovascular practice. In this Review, Rajagopalan and colleagues summarize the sources of greenhouse gas emissions related to the provision of cardiovascular health care and suggest strategies to reduce carbon emissions and costs, including the use of renewable energy, waste reduction and disease prevention.","PeriodicalId":18976,"journal":{"name":"Nature Reviews Cardiology","volume":"22 4","pages":"241-254"},"PeriodicalIF":41.7,"publicationDate":"2024-10-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142489618","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"OpenEP and EP Workbench for electrophysiology data analysis","authors":"Neil Bodagh,&nbsp;Steven E. Williams","doi":"10.1038/s41569-024-01092-0","DOIUrl":"10.1038/s41569-024-01092-0","url":null,"abstract":"In this Tools of the Trade article, Bodagh and Williams highlight the utility of OpenEP, an open-source platform that offers standardized solutions for storage and analysis of electroanatomic mapping data.","PeriodicalId":18976,"journal":{"name":"Nature Reviews Cardiology","volume":"22 1","pages":"3-3"},"PeriodicalIF":41.7,"publicationDate":"2024-10-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142487243","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Translation of pathophysiological mechanisms of atrial fibrosis into new diagnostic and therapeutic approaches","authors":"Ulrich Schotten,&nbsp;Andreas Goette,&nbsp;Sander Verheule","doi":"10.1038/s41569-024-01088-w","DOIUrl":"10.1038/s41569-024-01088-w","url":null,"abstract":"Atrial fibrosis is one of the main manifestations of atrial cardiomyopathy, an array of electrical, mechanical and structural alterations associated with atrial fibrillation (AF), stroke and heart failure. Atrial fibrosis can be both a cause and a consequence of AF and, once present, it accelerates the progression of AF. The pathophysiological mechanisms leading to atrial fibrosis are diverse and include stretch-induced activation of fibroblasts, systemic inflammatory processes, activation of coagulation factors and fibrofatty infiltrations. Importantly, atrial fibrosis can occur in different forms, such as reactive and replacement fibrosis. The diversity of atrial fibrosis mechanisms and patterns depends on sex, age and comorbidity profile, hampering the development of therapeutic strategies. In addition, the presence and severity of comorbidities often change over time, potentially causing temporal changes in the mechanisms underlying atrial fibrosis development. This Review summarizes the latest knowledge on the molecular and cellular mechanisms of atrial fibrosis, its association with comorbidities and the sex-related differences. We describe how the various patterns of atrial fibrosis translate into electrophysiological mechanisms that promote AF, and critically appraise the clinical applicability and limitations of diagnostic tools to quantify atrial fibrosis. Finally, we provide an overview of the newest therapeutic interventions under development and discuss relevant knowledge gaps related to the association between clinical manifestations and pathological mechanisms of atrial fibrosis and to the translation of this knowledge to a clinical setting. In this Review, Schotten and colleagues summarize the latest knowledge on the molecular and cellular mechanisms of atrial fibrosis, describe the electrophysiological manifestations of atrial fibrosis, critically appraise the diagnostic tools to quantify atrial fibrosis, discuss emerging therapeutic interventions, and highlight knowledge gaps and future research directions.","PeriodicalId":18976,"journal":{"name":"Nature Reviews Cardiology","volume":"22 4","pages":"225-240"},"PeriodicalIF":41.7,"publicationDate":"2024-10-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142487832","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}