Nature Reviews Cardiology最新文献

{"title":"Left atrial appendage closure non-inferior to NOACs in atrial fibrillation","authors":"Irene Fernández-Ruiz","doi":"10.1038/s41569-026-01289-5","DOIUrl":"10.1038/s41569-026-01289-5","url":null,"abstract":"In patients with atrial fibrillation without contraindications for anticoagulation, device-based left atrial appendage closure is non-inferior to therapy with non-vitamin K antagonist oral anticoagulants (NOACs) with respect to the composite end point of stroke, systemic embolism or death from cardiovascular causes at 3 years.","PeriodicalId":18976,"journal":{"name":"Nature Reviews Cardiology","volume":"23 6","pages":"382-382"},"PeriodicalIF":44.2,"publicationDate":"2026-04-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147648896","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Placebo-controlled evidence for symptomatic benefit of PCI for chronic total occlusion in stable angina","authors":"Irene Fernández-Ruiz","doi":"10.1038/s41569-026-01290-y","DOIUrl":"10.1038/s41569-026-01290-y","url":null,"abstract":"Findings from the double-blind, placebo-controlled, randomized ORBITA-CTO trial show that PCI for coronary artery chronic total occlusion reduces angina symptoms beyond placebo in appropriately selected patients.","PeriodicalId":18976,"journal":{"name":"Nature Reviews Cardiology","volume":"23 6","pages":"384-384"},"PeriodicalIF":44.2,"publicationDate":"2026-04-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147648999","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Extremes of temperature and cardiovascular mortality","authors":"Nam Nguyen, Urvish Jain","doi":"10.1038/s41569-026-01288-6","DOIUrl":"10.1038/s41569-026-01288-6","url":null,"abstract":"Nam Nguyen and Urvish Jain describe the landmark study linking exposure to extremely hot and cold temperatures to excess deaths caused by ischaemic heart disease, stroke and heart failure.","PeriodicalId":18976,"journal":{"name":"Nature Reviews Cardiology","volume":"23 7","pages":"454-454"},"PeriodicalIF":50.2,"publicationDate":"2026-04-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147648897","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Neutrophil extracellular traps in immunothrombosis","authors":"Tyler Artner","doi":"10.1038/s41569-026-01285-9","DOIUrl":"10.1038/s41569-026-01285-9","url":null,"abstract":"Tyler Artner describes the landmark study by Fuchs and colleagues that demonstrated the role of neutrophil extracellular traps in thrombus formation.","PeriodicalId":18976,"journal":{"name":"Nature Reviews Cardiology","volume":"23 6","pages":"387-387"},"PeriodicalIF":44.2,"publicationDate":"2026-04-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147633792","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Reframing atherothrombosis through the inflammation hypothesis","authors":"Art Schuermans","doi":"10.1038/s41569-026-01284-w","DOIUrl":"10.1038/s41569-026-01284-w","url":null,"abstract":"Schuermans highlights one of the first studies that provided robust evidence supporting the inflammatory hypothesis of atherosclerosis in humans.","PeriodicalId":18976,"journal":{"name":"Nature Reviews Cardiology","volume":"23 8","pages":"534-534"},"PeriodicalIF":50.2,"publicationDate":"2026-04-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147630188","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cardiovascular stent technologies for coronary and valvular heart disease: the potential of 3D printing for stent fabrication","authors":"Arian Ehterami, Sarah E. Motta, Melanie Generali, Fergal B. Coulter, Henryk Dreger, Volkmar Falk, Simon P. Hoerstrup, Maximilian Y. Emmert","doi":"10.1038/s41569-026-01275-x","DOIUrl":"10.1038/s41569-026-01275-x","url":null,"abstract":"Over the past two decades, stents have revolutionized the treatment of cardiovascular diseases, particularly coronary artery and valvular heart disease. In this Review, we evaluate the clinical challenges associated with these diseases, as well as the manufacturing strategies for both coronary and heart valve stents, with a focus on the emerging role of 3D printing. Specifically, we assess the advantages and limitations of clinically available metallic and polymeric stents for coronary artery disease and provide an overview of the metallic and biodegradable polymeric stents developed to treat valvular heart disease. Furthermore, we explore the capabilities of key 3D-printing methods for stent fabrication, highlighting their strengths and drawbacks, and discuss the regulatory considerations that govern the clinical translation of 3D printing-based coronary and valvular stents. Taken together, 3D-printing technologies offer new opportunities to customize geometry, control stent degradation and improve stent implantation approaches for patients with complex anatomies. By merging innovations in material science, manufacturing strategies and bioengineering, 3D-printing technology has a major role in the next generation of personalized and multifunctional cardiovascular stents. In this Review, Emmert and colleagues provide an overview of the clinically available metallic and polymeric stents used to treat coronary artery disease and valvular heart disease, and discuss the manufacturing techniques used to fabricate these stents, with a focus on the emerging role of 3D-printing technologies.","PeriodicalId":18976,"journal":{"name":"Nature Reviews Cardiology","volume":"23 10","pages":"701-725"},"PeriodicalIF":50.2,"publicationDate":"2026-03-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147524510","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Vascular smooth muscle cell plasticity in atherosclerosis","authors":"Laura Alonso-Herranz","doi":"10.1038/s41569-026-01283-x","DOIUrl":"10.1038/s41569-026-01283-x","url":null,"abstract":"Laura Alonso-Herranz discusses the study that demonstrated that vascular smooth muscle cells undergo clonal expansion within atherosclerotic plaques and adopt non-canonical features, a work that laid the foundation for subsequent studies on vascular smooth muscle cell plasticity in atherosclerosis.","PeriodicalId":18976,"journal":{"name":"Nature Reviews Cardiology","volume":"23 6","pages":"386-386"},"PeriodicalIF":44.2,"publicationDate":"2026-03-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147518502","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Global epidemiology of myocarditis: disparities in age, sex and geography","authors":"Karin Klingel, Carsten Tschöpe, Dong Keon Yon, George A. Mensah, Brittany N. Weber, Amy R. Kontorovich, Sooji Lee, Leslie T. Cooper, Enrico Ammirati","doi":"10.1038/s41569-026-01276-w","DOIUrl":"10.1038/s41569-026-01276-w","url":null,"abstract":"Myocarditis is a clinically and aetiologically heterogeneous disease that is associated with substantial morbidity and mortality, with approximately a million new cases and 17,000 deaths annually worldwide. However, the incidence of myocarditis varies widely by geographical region, sex and age. The aetiology of myocarditis is multifactorial and shaped by regional, demographic and socioeconomic contexts. In high-income countries, parvovirus B19 and human herpesvirus 6 are the predominant cardiotropic viruses that induce lymphocytic myocarditis, particularly in children. By contrast, in low-to-middle-income countries, dengue virus, human immunodeficiency virus, Plasmodium spp. (malaria) and Trypanosoma cruzi (Chagas disease) are the most common causative pathogens. Systemic autoimmune conditions and genetic predisposition are also implicated in the development of myocarditis, and increasingly recognized iatrogenic triggers of myocarditis include immune checkpoint inhibitors and gene therapies. This Review synthesizes epidemiological insights across diverse age groups and geographical regions, with a particular emphasis on the undiagnosed disease burden in low-resource settings. Variability in diagnostic criteria and the scarcity of heart-biopsy-confirmed data pose challenges to accurate estimates of global prevalence. Priorities for future research include multicentric registries, multi-omics-based risk stratification, and integration of novel biomarkers and advanced imaging techniques to refine myocarditis surveillance and treatment, and improve the accuracy of disease burden estimates. Myocarditis is an aetiologically diverse condition, associated with substantial morbidity and mortality worldwide. In this Review, Klingel et al. synthesize epidemiological insights across age groups and geographical regions, and discuss variability in diagnostics and management, with a particular emphasis on the underdiagnosed disease burden in low-resource settings.","PeriodicalId":18976,"journal":{"name":"Nature Reviews Cardiology","volume":"23 11","pages":"801-815"},"PeriodicalIF":50.2,"publicationDate":"2026-03-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147518501","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Drug-coated balloon angioplasty for coronary and peripheral artery disease: latest evidence and clinical indications","authors":"Rory Durand, Daniel O’Callaghan, J. J. Coughlan, Salvatore Cassese, Robert A. Byrne","doi":"10.1038/s41569-026-01262-2","DOIUrl":"10.1038/s41569-026-01262-2","url":null,"abstract":"Drug-coated balloons (DCBs) are devices used for the treatment of both coronary artery disease (CAD) and peripheral artery disease (PAD). One of the hypothesized advantages of DCB angioplasty over stent implantation is that DCB angioplasty does not result in the presence of a permanent metallic scaffold in the vessel wall. However, DCB angioplasty also has some important limitations, such as a potentially lower efficacy compared with other modalities; therefore, the role of DCBs in the treatment of CAD and PAD is not fully defined. Over the past 20 years, many clinical trials have been performed to investigate the use of these devices for a variety of indications. In this Review, we describe the device design and mechanism of action of DCBs and discuss important procedural considerations for successful DCB use. We summarize the scientific and clinical evidence for DCB angioplasty in CAD and PAD. In addition, we highlight the recommendations for DCB use in clinical practice guidelines and provide perspectives on the potential future role that DCB angioplasty might have in the treatment of CAD and PAD. Drug-coated balloons (DCBs) are used for the treatment of both coronary and peripheral artery disease. In this Review, Byrne and colleagues describe the device design and mechanism of action of DCBs, the scientific and clinical trial evidence for DCB angioplasty and important procedural considerations for successful DCB use.","PeriodicalId":18976,"journal":{"name":"Nature Reviews Cardiology","volume":"23 9","pages":"644-660"},"PeriodicalIF":50.2,"publicationDate":"2026-03-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147506734","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"ApoC-III inhibition: from regulatory approval to equitable implementation","authors":"Daniel Gaudet, Miriam Larouche, Erik S. G. Stroes","doi":"10.1038/s41569-026-01281-z","DOIUrl":"10.1038/s41569-026-01281-z","url":null,"abstract":"Apolipoprotein C-III (apoC-III) inhibition represents a major therapeutic advance in the management of severe hypertriglyceridaemia and pancreatitis. The potential role of apoC-III inhibition in preventing atherosclerotic cardiovascular disease will depend on rigorous outcomes data, appropriate patient selection and equitable implementation across healthcare systems. Beyond the lowering of triglyceride levels, meaningful clinical benefits and broad accessibility will determine the long-term success of this therapeutic approach.","PeriodicalId":18976,"journal":{"name":"Nature Reviews Cardiology","volume":"23 5","pages":"299-300"},"PeriodicalIF":44.2,"publicationDate":"2026-03-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147506735","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}