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Nature Reviews Cardiology最新文献

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Stenting for post-thrombotic syndrome 血栓形成后综合征的支架植入。
IF 44.2 1区 医学
Nature Reviews Cardiology Pub Date : 2026-04-21 DOI: 10.1038/s41569-026-01298-4
Gregory B. Lim
{"title":"Stenting for post-thrombotic syndrome","authors":"Gregory B. Lim","doi":"10.1038/s41569-026-01298-4","DOIUrl":"10.1038/s41569-026-01298-4","url":null,"abstract":"In the C-TRACT trial involving patients with post-thrombotic syndrome, the addition of endovascular treatment to standard care reduced the severity of symptoms and improved quality of life, but increased the risk of bleeding, compared with standard care alone.","PeriodicalId":18976,"journal":{"name":"Nature Reviews Cardiology","volume":"23 6","pages":"382-382"},"PeriodicalIF":44.2,"publicationDate":"2026-04-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147776893","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Beyond GLP1: modulating multiple nutrient-stimulated hormone pathways to reduce cardiovascular risk 超越GLP1：调节多种营养刺激激素通路以降低心血管风险。
IF 50.2 1区 医学
Nature Reviews Cardiology Pub Date : 2026-04-20 DOI: 10.1038/s41569-026-01296-6
Yu Mi Kang, Josephine Harrington, Vanita R. Aroda, Darren K. McGuire
{"title":"Beyond GLP1: modulating multiple nutrient-stimulated hormone pathways to reduce cardiovascular risk","authors":"Yu Mi Kang, Josephine Harrington, Vanita R. Aroda, Darren K. McGuire","doi":"10.1038/s41569-026-01296-6","DOIUrl":"10.1038/s41569-026-01296-6","url":null,"abstract":"A new generation of dual and triple receptor modulators targeting nutrient-stimulated hormone pathways are producing cardiometabolic effects that exceed any previous pharmacotherapy, with weight loss efficacy approaching that of bariatric surgery. Cardiovascular outcome trials that are planned or underway will determine whether such robust cardiometabolic potency through complementary receptor targeting translates into incremental cardiovascular protection, ideally with improved drug tolerability.","PeriodicalId":18976,"journal":{"name":"Nature Reviews Cardiology","volume":"23 7","pages":"449-451"},"PeriodicalIF":50.2,"publicationDate":"2026-04-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147725987","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Soft robotic devices for cardiovascular medicine 用于心血管医学的软体机器人装置。
IF 50.2 1区 医学
Nature Reviews Cardiology Pub Date : 2026-04-17 DOI: 10.1038/s41569-026-01287-7
Xing-Yu Ji  (, ), Jia-Qi Zhu  (, ), Ke Wu  (, ), Liu Wang  (, ), Tian-Yuan Xiong  (, ), Li Zhang  (, ), Mao Chen  (, )
{"title":"Soft robotic devices for cardiovascular medicine","authors":"Xing-Yu Ji \u0000 (, ), Jia-Qi Zhu \u0000 (, ), Ke Wu \u0000 (, ), Liu Wang \u0000 (, ), Tian-Yuan Xiong \u0000 (, ), Li Zhang \u0000 (, ), Mao Chen \u0000 (, )","doi":"10.1038/s41569-026-01287-7","DOIUrl":"10.1038/s41569-026-01287-7","url":null,"abstract":"Conventional, rigid simulators and therapeutic devices for cardiovascular disease have several fundamental limitations, such as poor biomimetic fidelity, substantial surgical invasiveness and mismatch at the tissue–device interface. Soft robotic devices, with tissue-like materials, structures and functions, are emerging as promising alternatives. In this Review, by matching clinical demands to technological breakthroughs, we identify three emerging complementary frontiers in which soft robotic devices are redefining cardiovascular medicine — soft robotic simulators, such as in vitro ventricular simulators and in vivo assistive simulators; soft robotic interventional instruments, such as percutaneous instruments, endovascular continuum instruments and untethered mini-scale robots; and soft robotic implants for vascular disease, arrhythmia and heart failure. We describe the unique advantages of soft robotic devices as well as their applicable scope and technical implementation. Finally, we highlight promising technological opportunities for next-generation soft cardiac devices, evaluate the clinical maturity of existing devices and propose a translational roadmap for the coming decade. With this Review, we aim to foster further integration of soft robotics into cardiovascular medicine by identifying device solutions with translational potential to address unmet clinical needs. Soft robotic devices, with tissue-like materials, structures and functions, are emerging as promising alternatives to rigid devices for cardiovascular disease, which have several fundamental limitations. In this Review, Ji and colleagues discuss three emerging frontiers in which soft robotic devices are redefining cardiovascular medicine: simulators, interventional instruments and implants for vascular disease, arrhythmia and heart failure.","PeriodicalId":18976,"journal":{"name":"Nature Reviews Cardiology","volume":"23 11","pages":"769-787"},"PeriodicalIF":50.2,"publicationDate":"2026-04-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147702128","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Fibrosis-targeted, immunosuppressive dendritic cells mitigate cardiac adverse remodelling 纤维化靶向，免疫抑制树突状细胞减轻心脏不良重构。
IF 44.2 1区 医学
Nature Reviews Cardiology Pub Date : 2026-04-16 DOI: 10.1038/s41569-026-01294-8
Irene Fernández-Ruiz
{"title":"Fibrosis-targeted, immunosuppressive dendritic cells mitigate cardiac adverse remodelling","authors":"Irene Fernández-Ruiz","doi":"10.1038/s41569-026-01294-8","DOIUrl":"10.1038/s41569-026-01294-8","url":null,"abstract":"Engineered immunosuppressive and fibrosis-targeted dendritic cells protect against pathological cardiac remodelling in animal models of ischaemic and pressure-overload-induced heart failure, including a non-human primate model of myocardial infarction.","PeriodicalId":18976,"journal":{"name":"Nature Reviews Cardiology","volume":"23 6","pages":"381-381"},"PeriodicalIF":44.2,"publicationDate":"2026-04-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147695157","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Medics for Rare Disease: advocating for rare disease training 罕见病医生：倡导罕见病培训。
IF 44.2 1区 医学
Nature Reviews Cardiology Pub Date : 2026-04-15 DOI: 10.1038/s41569-026-01291-x
Emma Huskinson, Helen Maginnis, Lucy McKay
{"title":"Medics for Rare Disease: advocating for rare disease training","authors":"Emma Huskinson, Helen Maginnis, Lucy McKay","doi":"10.1038/s41569-026-01291-x","DOIUrl":"10.1038/s41569-026-01291-x","url":null,"abstract":"Rare cardiovascular diseases affect 5% of the world’s population. Rare disease training for clinicians is essential to suspect and diagnose underlying rare diseases and to work effectively with patients to navigate uncertain health-care journeys. To raise awareness, Nature Reviews Cardiology has partnered with Medics for Rare Disease to produce a Collection of articles on rare cardiovascular diseases.","PeriodicalId":18976,"journal":{"name":"Nature Reviews Cardiology","volume":"23 6","pages":"379-380"},"PeriodicalIF":44.2,"publicationDate":"2026-04-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147685088","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Caution needed with microaxial flow pumps during high-risk PCI 高危PCI手术中使用微轴流泵需谨慎。
IF 44.2 1区 医学
Nature Reviews Cardiology Pub Date : 2026-04-13 DOI: 10.1038/s41569-026-01293-9
Gregory B. Lim
{"title":"Caution needed with microaxial flow pumps during high-risk PCI","authors":"Gregory B. Lim","doi":"10.1038/s41569-026-01293-9","DOIUrl":"10.1038/s41569-026-01293-9","url":null,"abstract":"In the CHIP-BCIS3 trial, elective left ventricular unloading with a microaxial flow pump did not reduce the risk of major adverse clinical outcomes in patients with severely impaired left ventricular function undergoing complex percutaneous coronary intervention.","PeriodicalId":18976,"journal":{"name":"Nature Reviews Cardiology","volume":"23 6","pages":"383-383"},"PeriodicalIF":44.2,"publicationDate":"2026-04-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147666572","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Ultrasound-facilitated fibrinolysis reduces bleeding in intermediate-risk pulmonary embolism 超声促进的纤溶可减少中危肺栓塞患者的出血。
IF 44.2 1区 医学
Nature Reviews Cardiology Pub Date : 2026-04-13 DOI: 10.1038/s41569-026-01292-w
Gregory B. Lim
{"title":"Ultrasound-facilitated fibrinolysis reduces bleeding in intermediate-risk pulmonary embolism","authors":"Gregory B. Lim","doi":"10.1038/s41569-026-01292-w","DOIUrl":"10.1038/s41569-026-01292-w","url":null,"abstract":"In the HI-PEITHO trial, ultrasound-facilitated, catheter-directed fibrinolysis plus anticoagulation improved outcomes compared with anticoagulation alone in patients with acute, intermediate-risk pulmonary embolism.","PeriodicalId":18976,"journal":{"name":"Nature Reviews Cardiology","volume":"23 6","pages":"385-385"},"PeriodicalIF":44.2,"publicationDate":"2026-04-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147666527","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Left atrial appendage closure non-inferior to NOACs in atrial fibrillation 房颤左心耳闭合优于NOACs。
IF 44.2 1区 医学
Nature Reviews Cardiology Pub Date : 2026-04-10 DOI: 10.1038/s41569-026-01289-5
Irene Fernández-Ruiz
{"title":"Left atrial appendage closure non-inferior to NOACs in atrial fibrillation","authors":"Irene Fernández-Ruiz","doi":"10.1038/s41569-026-01289-5","DOIUrl":"10.1038/s41569-026-01289-5","url":null,"abstract":"In patients with atrial fibrillation without contraindications for anticoagulation, device-based left atrial appendage closure is non-inferior to therapy with non-vitamin K antagonist oral anticoagulants (NOACs) with respect to the composite end point of stroke, systemic embolism or death from cardiovascular causes at 3 years.","PeriodicalId":18976,"journal":{"name":"Nature Reviews Cardiology","volume":"23 6","pages":"382-382"},"PeriodicalIF":44.2,"publicationDate":"2026-04-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147648896","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Placebo-controlled evidence for symptomatic benefit of PCI for chronic total occlusion in stable angina 稳定型心绞痛慢性全闭塞PCI治疗的症状性获益的安慰剂对照证据。
IF 44.2 1区 医学
Nature Reviews Cardiology Pub Date : 2026-04-10 DOI: 10.1038/s41569-026-01290-y
Irene Fernández-Ruiz
{"title":"Placebo-controlled evidence for symptomatic benefit of PCI for chronic total occlusion in stable angina","authors":"Irene Fernández-Ruiz","doi":"10.1038/s41569-026-01290-y","DOIUrl":"10.1038/s41569-026-01290-y","url":null,"abstract":"Findings from the double-blind, placebo-controlled, randomized ORBITA-CTO trial show that PCI for coronary artery chronic total occlusion reduces angina symptoms beyond placebo in appropriately selected patients.","PeriodicalId":18976,"journal":{"name":"Nature Reviews Cardiology","volume":"23 6","pages":"384-384"},"PeriodicalIF":44.2,"publicationDate":"2026-04-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147648999","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Extremes of temperature and cardiovascular mortality 极端温度和心血管死亡率。
IF 50.2 1区 医学
Nature Reviews Cardiology Pub Date : 2026-04-10 DOI: 10.1038/s41569-026-01288-6
Nam Nguyen, Urvish Jain
{"title":"Extremes of temperature and cardiovascular mortality","authors":"Nam Nguyen, Urvish Jain","doi":"10.1038/s41569-026-01288-6","DOIUrl":"10.1038/s41569-026-01288-6","url":null,"abstract":"Nam Nguyen and Urvish Jain describe the landmark study linking exposure to extremely hot and cold temperatures to excess deaths caused by ischaemic heart disease, stroke and heart failure.","PeriodicalId":18976,"journal":{"name":"Nature Reviews Cardiology","volume":"23 7","pages":"454-454"},"PeriodicalIF":50.2,"publicationDate":"2026-04-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147648897","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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