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Periodontal treatment reduces AF recurrence 牙周治疗可减少房颤复发
IF 49.6 1区 医学
Nature Reviews Cardiology Pub Date : 2024-04-25 DOI: 10.1038/s41569-024-01036-8
Gregory B. Lim
{"title":"Periodontal treatment reduces AF recurrence","authors":"Gregory B. Lim","doi":"10.1038/s41569-024-01036-8","DOIUrl":"10.1038/s41569-024-01036-8","url":null,"abstract":"Treatment for periodontal disease might reduce the recurrence of atrial fibrillation (AF) in patients undergoing ablation, suggesting that periodontitis is a modifiable risk factor for AF.","PeriodicalId":18976,"journal":{"name":"Nature Reviews Cardiology","volume":null,"pages":null},"PeriodicalIF":49.6,"publicationDate":"2024-04-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140648671","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Targeting immune cell recruitment in atherosclerosis 以动脉粥样硬化中的免疫细胞招募为目标
IF 41.7 1区 医学
Nature Reviews Cardiology Pub Date : 2024-04-25 DOI: 10.1038/s41569-024-01023-z
Yvonne Döring, Emiel P. C. van der Vorst, Christian Weber
{"title":"Targeting immune cell recruitment in atherosclerosis","authors":"Yvonne Döring, Emiel P. C. van der Vorst, Christian Weber","doi":"10.1038/s41569-024-01023-z","DOIUrl":"10.1038/s41569-024-01023-z","url":null,"abstract":"Atherosclerosis is the primary underlying cause of myocardial infarction and stroke. Atherosclerotic cardiovascular disease is characterized by a chronic inflammatory reaction in medium-to-large-sized arteries, with its onset and perpetuation driven by leukocytes infiltrating the subendothelial space. Activation of endothelial cells triggered by hyperlipidaemia and lipoprotein retention in the arterial intima initiates the accumulation of pro-inflammatory leukocytes in the arterial wall, fostering the progression of atherosclerosis. This inflammatory response is coordinated by an array of soluble mediators, namely cytokines and chemokines, that amplify inflammation both locally and systemically and are complemented by tissue-specific molecules that regulate the homing, adhesion and transmigration of leukocytes. Despite abundant evidence from mouse models, only a few therapies targeting leukocytes in atherosclerosis have been assessed in humans. The major challenges for the clinical translation of these therapies include the lack of tissue specificity and insufficient selectivity of inhibition strategies. In this Review, we discuss the latest research on receptor–ligand pairs and interactors that regulate leukocyte influx into the inflamed artery wall, primarily focusing on studies that used pharmacological interventions. We also discuss mechanisms that promote the resolution of inflammation and highlight how major findings from these research areas hold promise as potential therapeutic strategies for atherosclerotic cardiovascular disease. In this Review, the authors discuss the receptors, ligands and interactors that regulate immune cell recruitment in atherosclerosis, describe mechanisms that promote the resolution of inflammation in atherosclerotic lesions, and highlight potential strategies to target these pathways for the treatment of atherosclerotic cardiovascular disease.","PeriodicalId":18976,"journal":{"name":"Nature Reviews Cardiology","volume":null,"pages":null},"PeriodicalIF":41.7,"publicationDate":"2024-04-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.nature.com/articles/s41569-024-01023-z.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140648752","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The coronary sinus reducer improves angina symptoms in patients with stable CAD 冠状窦减压器可改善稳定型 CAD 患者的心绞痛症状
IF 49.6 1区 医学
Nature Reviews Cardiology Pub Date : 2024-04-25 DOI: 10.1038/s41569-024-01033-x
Karina Huynh
{"title":"The coronary sinus reducer improves angina symptoms in patients with stable CAD","authors":"Karina Huynh","doi":"10.1038/s41569-024-01033-x","DOIUrl":"10.1038/s41569-024-01033-x","url":null,"abstract":"Findings from the ORBITA-COSMIC trial show that treatment of patients with stable coronary artery disease using a coronary sinus reducer improves angina symptoms but does not increase transmural myocardial perfusion.","PeriodicalId":18976,"journal":{"name":"Nature Reviews Cardiology","volume":null,"pages":null},"PeriodicalIF":49.6,"publicationDate":"2024-04-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140648792","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
RNA-based therapies targeting APOC3 lower triglyceride levels in patients with hypertriglyceridaemia 针对 APOC3 的 RNA 型疗法可降低高甘油三酯血症患者的甘油三酯水平
IF 49.6 1区 医学
Nature Reviews Cardiology Pub Date : 2024-04-23 DOI: 10.1038/s41569-024-01034-w
Karina Huynh
{"title":"RNA-based therapies targeting APOC3 lower triglyceride levels in patients with hypertriglyceridaemia","authors":"Karina Huynh","doi":"10.1038/s41569-024-01034-w","DOIUrl":"10.1038/s41569-024-01034-w","url":null,"abstract":"Three randomized clinical trials presented at ACC.24 demonstrate that olezarsen and plozasiran, RNA-based therapies that target APOC3, can robustly reduce plasma triglyceride levels in patients with moderate to severe hypertriglyceridaemia.","PeriodicalId":18976,"journal":{"name":"Nature Reviews Cardiology","volume":null,"pages":null},"PeriodicalIF":49.6,"publicationDate":"2024-04-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140639759","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Benefits of ninerafaxstat in non-obstructive hypertrophic cardiomyopathy 尼那非司他对非阻塞性肥厚型心肌病的益处
IF 49.6 1区 医学
Nature Reviews Cardiology Pub Date : 2024-04-23 DOI: 10.1038/s41569-024-01032-y
Gregory B. Lim
{"title":"Benefits of ninerafaxstat in non-obstructive hypertrophic cardiomyopathy","authors":"Gregory B. Lim","doi":"10.1038/s41569-024-01032-y","DOIUrl":"10.1038/s41569-024-01032-y","url":null,"abstract":"According to data from the IMPROVE-HCM trial, ninerafaxstat is well tolerated by patients with symptomatic non-obstructive hypertrophic cardiomyopathy and improves exercise performance among those who are most symptomatically limited.","PeriodicalId":18976,"journal":{"name":"Nature Reviews Cardiology","volume":null,"pages":null},"PeriodicalIF":49.6,"publicationDate":"2024-04-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140637549","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Strategies for the delivery of sex-based equity in cardiovascular clinical trials 在心血管临床试验中实现性别公平的策略
IF 49.6 1区 医学
Nature Reviews Cardiology Pub Date : 2024-04-23 DOI: 10.1038/s41569-024-01025-x
Julie Sanders, Tim Clayton, Stacey Matthews, Sarah Murray, Lynn Laidlaw, Richard Evans, Rochelle Wynne
{"title":"Strategies for the delivery of sex-based equity in cardiovascular clinical trials","authors":"Julie Sanders, Tim Clayton, Stacey Matthews, Sarah Murray, Lynn Laidlaw, Richard Evans, Rochelle Wynne","doi":"10.1038/s41569-024-01025-x","DOIUrl":"10.1038/s41569-024-01025-x","url":null,"abstract":"The under-representation of women in cardiovascular clinical trials persists across participant, clinician and research roles. This gap perpetuates health inequity and hampers the generation, translation and implementation of optimal evidence-based care. Urgent action is needed to address barriers, promote diversity, and ensure inclusive trial design and health-care delivery and dissemination, for more equitable cardiovascular health.","PeriodicalId":18976,"journal":{"name":"Nature Reviews Cardiology","volume":null,"pages":null},"PeriodicalIF":49.6,"publicationDate":"2024-04-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140637645","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Heart pump increases survival in STEMI-related cardiogenic shock 心脏泵可提高 STEMI 相关性心源性休克患者的存活率
IF 49.6 1区 医学
Nature Reviews Cardiology Pub Date : 2024-04-23 DOI: 10.1038/s41569-024-01035-9
Jennifer Harman
{"title":"Heart pump increases survival in STEMI-related cardiogenic shock","authors":"Jennifer Harman","doi":"10.1038/s41569-024-01035-9","DOIUrl":"10.1038/s41569-024-01035-9","url":null,"abstract":"Data from the DanGer Shock trial demonstrate that implantation of a microaxial flow pump in patients with ST-segment elevation myocardial infarction complicated by cardiogenic shock increases the survival rate compared with standard care alone.","PeriodicalId":18976,"journal":{"name":"Nature Reviews Cardiology","volume":null,"pages":null},"PeriodicalIF":49.6,"publicationDate":"2024-04-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140639903","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
No benefit of β-blockers after myocardial infarction with preserved ejection fraction 射血分数保留的心肌梗死后使用β-受体阻滞剂无益
IF 49.6 1区 医学
Nature Reviews Cardiology Pub Date : 2024-04-22 DOI: 10.1038/s41569-024-01030-0
Gregory B. Lim
{"title":"No benefit of β-blockers after myocardial infarction with preserved ejection fraction","authors":"Gregory B. Lim","doi":"10.1038/s41569-024-01030-0","DOIUrl":"10.1038/s41569-024-01030-0","url":null,"abstract":"In the REDUCE-AMI trial, the use of β-blockers in patients with acute myocardial infarction (MI) who have undergone early coronary angiography and have a preserved left ventricular ejection fraction did not reduce the risk of death or new MI compared with no β-blocker use.","PeriodicalId":18976,"journal":{"name":"Nature Reviews Cardiology","volume":null,"pages":null},"PeriodicalIF":49.6,"publicationDate":"2024-04-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140637691","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Self-expanding valves more beneficial than balloon-expandable valves in patients with a small aortic annulus 在主动脉瓣环较小的患者中，自扩张瓣膜比球囊扩张瓣膜更有益
IF 49.6 1区 医学
Nature Reviews Cardiology Pub Date : 2024-04-19 DOI: 10.1038/s41569-024-01027-9
Karina Huynh
{"title":"Self-expanding valves more beneficial than balloon-expandable valves in patients with a small aortic annulus","authors":"Karina Huynh","doi":"10.1038/s41569-024-01027-9","DOIUrl":"10.1038/s41569-024-01027-9","url":null,"abstract":"In patients with symptomatic aortic stenosis and a small aortic annulus, a self-expanding valve has similar rates of clinical outcomes at 1 year and lower rates of bioprosthetic dysfunction compared with a balloon-expandable valve.","PeriodicalId":18976,"journal":{"name":"Nature Reviews Cardiology","volume":null,"pages":null},"PeriodicalIF":49.6,"publicationDate":"2024-04-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140621580","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Gut bacteria can break down cholesterol 肠道细菌能分解胆固醇
IF 49.6 1区 医学
Nature Reviews Cardiology Pub Date : 2024-04-16 DOI: 10.1038/s41569-024-01026-w
Irene Fernández-Ruiz
{"title":"Gut bacteria can break down cholesterol","authors":"Irene Fernández-Ruiz","doi":"10.1038/s41569-024-01026-w","DOIUrl":"10.1038/s41569-024-01026-w","url":null,"abstract":"A new study identifies a group of gut bacteria that can metabolize cholesterol and are associated with lower plasma cholesterol levels.","PeriodicalId":18976,"journal":{"name":"Nature Reviews Cardiology","volume":null,"pages":null},"PeriodicalIF":49.6,"publicationDate":"2024-04-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140556643","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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