Nature Reviews Cardiology最新文献

{"title":"MicroRNA-132 inhibitor is well-tolerated in patients with MI and LV dysfunction","authors":"Karina Huynh","doi":"10.1038/s41569-026-01308-5","DOIUrl":"10.1038/s41569-026-01308-5","url":null,"abstract":"In the randomized, phase II HF-REVERT trial, the miR-132 inhibitor CDR132L was well-tolerated and showed pharmacodynamic target engagement in patients with myocardial infarction and reduced left ventricular ejection fraction, but did not improve ventricular remodelling compared with placebo.","PeriodicalId":18976,"journal":{"name":"Nature Reviews Cardiology","volume":"23 7","pages":"453-453"},"PeriodicalIF":50.2,"publicationDate":"2026-05-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148043052","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The beating heart as a tumour-suppressive niche","authors":"Jianhua Xiong","doi":"10.1038/s41569-026-01307-6","DOIUrl":"10.1038/s41569-026-01307-6","url":null,"abstract":"The beating of the heart does more than circulate blood; its rhythmic contractions generate forces to create a biomechanical environment that suppresses tumour growth. This finding, from a new study by Ciucci and colleagues, highlights an underappreciated role for cardiac mechanics in cancer biology.","PeriodicalId":18976,"journal":{"name":"Nature Reviews Cardiology","volume":"23 8","pages":"535-536"},"PeriodicalIF":50.2,"publicationDate":"2026-05-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147988121","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Eugene Braunwald (1929–2026)","authors":"Peter Libby","doi":"10.1038/s41569-026-01303-w","DOIUrl":"10.1038/s41569-026-01303-w","url":null,"abstract":"In this Obituary, Peter Libby reflects on the life and achievements of Eugene Braunwald, celebrated as the father of modern cardiology.","PeriodicalId":18976,"journal":{"name":"Nature Reviews Cardiology","volume":"23 8","pages":"529-529"},"PeriodicalIF":50.2,"publicationDate":"2026-05-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148452177","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Engineered blood clots designed using click clotting technology can rapidly seal bleeding sites","authors":"Karina Huynh","doi":"10.1038/s41569-026-01305-8","DOIUrl":"10.1038/s41569-026-01305-8","url":null,"abstract":"Novel engineered blood clots, generated via the rapid crosslinking of red blood cells into tough cytogels, are superior to native blood clots in fracture toughness and adherence to tissues, demonstrating the potential of using ‘click clotting’ technology in the management of haemorrhage, surgical bleeding and bleeding disorders.","PeriodicalId":18976,"journal":{"name":"Nature Reviews Cardiology","volume":"23 7","pages":"452-452"},"PeriodicalIF":50.2,"publicationDate":"2026-05-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147973935","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Epidemiology of non-ischaemic dilated cardiomyopathy.","authors":"Noemí Ramos-López, Fernando Domínguez, Juan Pablo Ochoa, Enrique Lara-Pezzi, Pablo Garcia-Pavia","doi":"10.1038/s41569-026-01300-z","DOIUrl":"https://doi.org/10.1038/s41569-026-01300-z","url":null,"abstract":"<p><p>Dilated cardiomyopathy, defined by left ventricular dilatation and systolic dysfunction, is a major cause of heart failure, heart transplantation and sudden cardiac death, especially in young and middle-aged adults. Dilated cardiomyopathy of non-ischaemic aetiology is more common than once thought, with current prevalence estimated at around 1 in 220 based on cardiac magnetic resonance imaging studies, and the prevalence is twice as high in men than in women. However, the true prevalence could be even higher when early or subclinical forms of the disease are considered. Advances in genetic technologies over the past three decades have led to improved understanding of the genetic basis of non-ischaemic dilated cardiomyopathy and the identification of pathogenic variants in 30-40% of patients. The genetic architecture of this disease is complex and heterogeneous. Rather than being a strictly monogenic disorder, dilated cardiomyopathy results from a combination of monogenic and polygenic factors, along with gene-environment interactions as critical modifiers of disease penetrance and phenotype. A deeper understanding of the genetic factors and epidemiological landscape of dilated cardiomyopathy is crucial for improving clinical management and optimizing screening protocols and public health strategies.</p>","PeriodicalId":18976,"journal":{"name":"Nature Reviews Cardiology","volume":" ","pages":""},"PeriodicalIF":44.2,"publicationDate":"2026-05-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147973940","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Fractional flow reserve estimated from the invasive angiogram: limitations and next steps","authors":"Nils P. Johnson","doi":"10.1038/s41569-026-01302-x","DOIUrl":"10.1038/s41569-026-01302-x","url":null,"abstract":"Fractional flow reserve (FFR) estimated from an invasive coronary angiogram produces a biased estimate, overstating the severity of the lesion and leading to unnecessary revascularization without clinical or cost benefits. The validity of findings from major angiography FFR trials are limited by suboptimal trial design and the enrolment of low-risk populations. I argue for improved upstream testing as an alternative strategy.","PeriodicalId":18976,"journal":{"name":"Nature Reviews Cardiology","volume":"23 7","pages":"445-446"},"PeriodicalIF":50.2,"publicationDate":"2026-05-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147931613","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"CD8⁺ T cells in atherosclerosis and coronary artery disease.","authors":"Ishita Tandon, Mohamed Yosri, Hadeer Soliman, Alaa M Khalifa, Klaus Ley, Hossam A Abdelsamed","doi":"10.1038/s41569-026-01295-7","DOIUrl":"10.1038/s41569-026-01295-7","url":null,"abstract":"<p><p>Cardiovascular diseases remain a global health challenge, with >600 million cases reported annually. Atherosclerosis is a common pathology that underlies various cardiovascular diseases, such as myocardial infarction and stroke. Both the innate and adaptive immune systems have crucial roles in the progression of atherosclerosis. CD8⁺ T cells are the most clonally expanded adaptive immune cells in human atherosclerotic plaques, but whether these cells are pro-atherogenic or atheroprotective during the different stages of atherosclerosis development and progression is unclear. In this Review, we summarize the latest knowledge on the role of CD8⁺ T cells in atherosclerosis. We discuss the phenotypic, functional and transcriptional features of CD8⁺ T cells in atherosclerosis and shed light on their involvement in comorbidities to understand the landscape of CD8⁺ T cells during the progression of atherosclerosis. We also highlight key research gaps and questions that need to be addressed to improve our understanding of the functions of CD8⁺ T cells in atherosclerosis. Targeting CD8⁺ T cells could provide potential therapeutic avenues to prevent and mitigate adverse cardiovascular events in patients with atherosclerosis and coronary heart disease.</p>","PeriodicalId":18976,"journal":{"name":"Nature Reviews Cardiology","volume":" ","pages":""},"PeriodicalIF":50.2,"publicationDate":"2026-05-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13491959/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147840316","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Digital screening and decision-support tools in equitable preventive cardiology","authors":"Dang Nguyen,&nbsp;Tuan Vinh","doi":"10.1038/s41569-026-01299-3","DOIUrl":"10.1038/s41569-026-01299-3","url":null,"abstract":"Nguyen and Vinh discuss the insights from the Apple Heart Study on digital screening for atrial fibrillation and highlight the importance of equitable access in digital health.","PeriodicalId":18976,"journal":{"name":"Nature Reviews Cardiology","volume":"23 7","pages":"455-455"},"PeriodicalIF":50.2,"publicationDate":"2026-04-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147817911","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Base editing and silencing of PCSK9 shows clinical promise in humans","authors":"Archna Bajaj,&nbsp;Daniel J. Rader","doi":"10.1038/s41569-026-01297-5","DOIUrl":"10.1038/s41569-026-01297-5","url":null,"abstract":"Base editing therapies to silence PCSK9 have entered clinical trials, and early results show promise for a durable ‘one-and-done’ therapy to lower plasma LDL-cholesterol levels.","PeriodicalId":18976,"journal":{"name":"Nature Reviews Cardiology","volume":"23 7","pages":"447-448"},"PeriodicalIF":50.2,"publicationDate":"2026-04-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147753154","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Local calcium dynamics and signalling in cardiomyocytes","authors":"Jean-Pierre Benitah,&nbsp;Laetitia Pereira,&nbsp;Romain Perrier,&nbsp;Jean-Jacques Mercadier,&nbsp;Jessica Sabourin,&nbsp;Ana María Gómez","doi":"10.1038/s41569-026-01286-8","DOIUrl":"10.1038/s41569-026-01286-8","url":null,"abstract":"Calcium (Ca²⁺) signalling is essential for cardiomyocyte function, regulating excitation–contraction coupling and excitation–transcription coupling, and contributing to mitochondrial energy production (excitation–bioenergetics coupling). In this Review, we explore the role of Ca²⁺ microdomains, which compartmentalize Ca²⁺ signalling to ensure efficient cardiac function. We first describe the organization of these microdomains, followed by their functional importance, pathological alterations in heart failure and potential therapeutic strategies targeting key Ca²⁺-signalling mechanisms. The dyad, a crucial excitation–contraction coupling microdomain, brings L-type Ca²⁺ channels and ryanodine receptor Ca²⁺-release channels (RYR2) into close proximity, facilitating Ca²⁺-induced Ca²⁺ release for cardiomyocyte contraction. In heart failure, dyadic remodelling and altered Ca²⁺ handling contribute to cardiac contractile dysfunction and arrhythmogenesis. Emerging research shows that dyads are dynamic, rapidly adapting to modulators such as β-adrenergic signalling, offering new therapeutic targets. Under stress conditions, dyadic proteins can translocate to the nucleus to regulate gene expression. In addition to excitation–contraction coupling, which operates on a beat-to-beat basis, Ca²⁺ has additional roles in cardiomyocytes. Nuclear Ca²⁺ regulates the expression of genes related to hypertrophy, including those encoding Ca²⁺ channels and transporters. Disruptions in these microdomains drive pathological remodelling in heart failure and arrhythmias. Understanding Ca²⁺ microdomains is crucial for developing targeted interventions to restore cardiac function while minimizing pro-arrhythmic risks. Calcium ions (Ca2+) are essential for cardiomyocyte function. In this Review, Gomez and colleagues describe how Ca2+ signalling in microdomains and nanodomains links electrical excitation to cardiomyocyte contraction, gene transcription and mitochondrial bioenergetics, and how this coupling is altered and might be therapeutically targeted in disease states.","PeriodicalId":18976,"journal":{"name":"Nature Reviews Cardiology","volume":"23 11","pages":"816-831"},"PeriodicalIF":50.2,"publicationDate":"2026-04-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147733967","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}