发布求助
文献互助 智能选刊 最新文献

Nature Reviews Cardiology最新文献

筛选
英文 中文
Leadless and extravascular cardiac resynchronization therapy: the future for CRT? 无铅和血管外心脏再同步化治疗：CRT的未来？
IF 44.2 1区 医学
Nature Reviews Cardiology Pub Date : 2025-06-06 DOI: 10.1038/s41569-025-01178-3
Steven Niederer, Henry Chubb, Kenneth C. Bilchick, Christopher Aldo Rinaldi
{"title":"Leadless and extravascular cardiac resynchronization therapy: the future for CRT?","authors":"Steven Niederer, Henry Chubb, Kenneth C. Bilchick, Christopher Aldo Rinaldi","doi":"10.1038/s41569-025-01178-3","DOIUrl":"10.1038/s41569-025-01178-3","url":null,"abstract":"Cardiac resynchronization therapy is used to treat dyssynchronous heart failure. Lead-related complications and anatomical constraints can limit pacing lead placement, but leadless systems are now becoming available. These new systems overcome lead-related issues, offering a new option for patients with complex disease (such as congenital heart disease) by eliminating intravascular hardware.","PeriodicalId":18976,"journal":{"name":"Nature Reviews Cardiology","volume":"22 8","pages":"529-531"},"PeriodicalIF":44.2,"publicationDate":"2025-06-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144237229","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Cardiovascular involvement in glycogen storage diseases 糖原储存病与心血管的关系
IF 49.6 1区 医学
Nature Reviews Cardiology Pub Date : 2025-06-05 DOI: 10.1038/s41569-025-01171-w
Tomàs Pinós, Richard M. Cubbon, Alfredo Santalla, Carmen Fiuza-Luces, Alejandro Santos-Lozano, Miguel A. Martín, Joaquín Arenas, Joachim Nielsen, Niels Ørtenblad, Alejandro Lucia
{"title":"Cardiovascular involvement in glycogen storage diseases","authors":"Tomàs Pinós, Richard M. Cubbon, Alfredo Santalla, Carmen Fiuza-Luces, Alejandro Santos-Lozano, Miguel A. Martín, Joaquín Arenas, Joachim Nielsen, Niels Ørtenblad, Alejandro Lucia","doi":"10.1038/s41569-025-01171-w","DOIUrl":"https://doi.org/10.1038/s41569-025-01171-w","url":null,"abstract":"<p>Glycogen storage diseases are rare conditions affecting both sexes that are caused by inherited deficiencies of enzymes involved either in glycogen synthesis or breakdown, or in glycolysis. The liver and skeletal muscle are usually the most affected tissues. However, because glycogen has an important role in cardiac development and function, several glycogen storage diseases are associated, at least indirectly, with cardiac disorders, some of which have severe consequences from the first months of life. Early identification of these conditions is, therefore, an important issue, and implementation of strategies to prevent fatal outcomes due to cardiovascular disease is vital. In this Review, we discuss the pathophysiological mechanisms and the preclinical, clinical and epidemiological evidence for cardiovascular involvement in various glycogen storage diseases. We also describe interventions that can help preserve heart function, including changes in nutrition and exercise, as well as the few available molecular therapies to address the underlying metabolic anomalies.</p>","PeriodicalId":18976,"journal":{"name":"Nature Reviews Cardiology","volume":"17 1","pages":""},"PeriodicalIF":49.6,"publicationDate":"2025-06-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144218799","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Think Aorta: aortic dissection awareness and perspectives from the patient 思考主动脉：患者对主动脉夹层的认识和观点
IF 44.2 1区 医学
Nature Reviews Cardiology Pub Date : 2025-06-03 DOI: 10.1038/s41569-025-01177-4
Gareth Owens
{"title":"Think Aorta: aortic dissection awareness and perspectives from the patient","authors":"Gareth Owens","doi":"10.1038/s41569-025-01177-4","DOIUrl":"10.1038/s41569-025-01177-4","url":null,"abstract":"Aortic dissection has long been considered a rare, unpreventable and inevitably fatal disease. However, recent advances now prove otherwise. The patient-led Think Aorta campaign is challenging old thinking, improving diagnosis and advocating for better care, such as family screening. Patient advocacy and recent international guidelines classifying the aorta as an organ are catalysts for further improvements in patient care.","PeriodicalId":18976,"journal":{"name":"Nature Reviews Cardiology","volume":"22 8","pages":"527-528"},"PeriodicalIF":44.2,"publicationDate":"2025-06-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144201638","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Networking effectively with cardiovascular societies: strategies for meaningful engagement and career advancement 有效地与心血管协会建立联系：有意义的参与和职业发展的策略
IF 44.2 1区 医学
Nature Reviews Cardiology Pub Date : 2025-05-29 DOI: 10.1038/s41569-025-01174-7
Purvi Parwani, F. Aaysha Cader
{"title":"Networking effectively with cardiovascular societies: strategies for meaningful engagement and career advancement","authors":"Purvi Parwani,&nbsp;F. Aaysha Cader","doi":"10.1038/s41569-025-01174-7","DOIUrl":"10.1038/s41569-025-01174-7","url":null,"abstract":"Effective engagement with cardiovascular societies enhances professional development, academic growth and leadership opportunities. We describe practical strategies for cardiovascular professionals to connect with their peers, seek mentorship, advance professionally and contribute as active members of the cardiovascular society, to develop an impactful career and advance the field of cardiac medicine.","PeriodicalId":18976,"journal":{"name":"Nature Reviews Cardiology","volume":"22 7","pages":"461-462"},"PeriodicalIF":44.2,"publicationDate":"2025-05-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144164849","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Reply to ‘Neuroendocrine regulatory effects of sex hormones on salt sensitivity of blood pressure’ 回复“性激素对血压盐敏感性的神经内分泌调节作用”
IF 44.2 1区 医学
Nature Reviews Cardiology Pub Date : 2025-05-28 DOI: 10.1038/s41569-025-01176-5
Sepiso K. Masenga, Annet Kirabo
{"title":"Reply to ‘Neuroendocrine regulatory effects of sex hormones on salt sensitivity of blood pressure’","authors":"Sepiso K. Masenga,&nbsp;Annet Kirabo","doi":"10.1038/s41569-025-01176-5","DOIUrl":"10.1038/s41569-025-01176-5","url":null,"abstract":"","PeriodicalId":18976,"journal":{"name":"Nature Reviews Cardiology","volume":"22 9","pages":"690-691"},"PeriodicalIF":44.2,"publicationDate":"2025-05-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144153483","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Neuroendocrine regulatory effects of sex hormones on salt sensitivity of blood pressure 性激素对血压盐敏感性的神经内分泌调节作用
IF 44.2 1区 医学
Nature Reviews Cardiology Pub Date : 2025-05-28 DOI: 10.1038/s41569-025-01175-6
Mi Zhou  (, ), Bing-hua Wang  (, ), Yu-chan Wang  (, ), Wen-jun Zhang  (, ), Li-xue Yin  (, )
{"title":"Neuroendocrine regulatory effects of sex hormones on salt sensitivity of blood pressure","authors":"Mi Zhou \u0000 (,&nbsp;),&nbsp;Bing-hua Wang \u0000 (,&nbsp;),&nbsp;Yu-chan Wang \u0000 (,&nbsp;),&nbsp;Wen-jun Zhang \u0000 (,&nbsp;),&nbsp;Li-xue Yin \u0000 (,&nbsp;)","doi":"10.1038/s41569-025-01175-6","DOIUrl":"10.1038/s41569-025-01175-6","url":null,"abstract":"","PeriodicalId":18976,"journal":{"name":"Nature Reviews Cardiology","volume":"22 9","pages":"689-689"},"PeriodicalIF":44.2,"publicationDate":"2025-05-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144153577","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Gene therapy for cardiac arrhythmias 心律失常的基因治疗
IF 49.6 1区 医学
Nature Reviews Cardiology Pub Date : 2025-05-23 DOI: 10.1038/s41569-025-01168-5
Sahej Bains, John R. Giudicessi, Katja E. Odening, Michael J. Ackerman
{"title":"Gene therapy for cardiac arrhythmias","authors":"Sahej Bains, John R. Giudicessi, Katja E. Odening, Michael J. Ackerman","doi":"10.1038/s41569-025-01168-5","DOIUrl":"https://doi.org/10.1038/s41569-025-01168-5","url":null,"abstract":"<p>Cardiovascular diseases are the leading cause of death globally, with cardiac arrhythmias contributing substantially to this burden. Gene therapy, which directly targets the underlying disease pathobiology, offers an appealing treatment strategy for cardiac arrhythmias owing to its potential as a one-time, curative solution. Over the past two decades, substantial efforts have been made to develop new gene therapy approaches that overcome the limitations of conventional treatments. In this Review, we describe the rationale for gene therapy to treat cardiac arrhythmias; discuss advantages and disadvantages of gene silencing, gene replacement, gene suppression-and-replacement and gene editing technologies; summarize vector modalities and delivery approaches used in the field; present examples of gene therapy strategies used for atrial and ventricular arrhythmias; and highlight the current challenges and limitations in the gene therapy field.</p>","PeriodicalId":18976,"journal":{"name":"Nature Reviews Cardiology","volume":"55 1","pages":""},"PeriodicalIF":49.6,"publicationDate":"2025-05-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144130677","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
LDL-cholesterol lowering with obicetrapib obictrapib降低ldl -胆固醇
IF 44.2 1区 医学
Nature Reviews Cardiology Pub Date : 2025-05-22 DOI: 10.1038/s41569-025-01173-8
Gregory B. Lim
{"title":"LDL-cholesterol lowering with obicetrapib","authors":"Gregory B. Lim","doi":"10.1038/s41569-025-01173-8","DOIUrl":"10.1038/s41569-025-01173-8","url":null,"abstract":"In the TANDEM and BROADWAY clinical trials, treatment with the CETP inhibitor obicetrapib in addition to background lipid-lowering therapy significantly reduced plasma LDL-cholesterol levels.","PeriodicalId":18976,"journal":{"name":"Nature Reviews Cardiology","volume":"22 7","pages":"463-463"},"PeriodicalIF":44.2,"publicationDate":"2025-05-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144113340","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
From data to impact: why conference presentation skills are essential for cardiovascular research dissemination 从数据到影响：为什么会议演讲技巧对心血管研究传播至关重要
IF 44.2 1区 医学
Nature Reviews Cardiology Pub Date : 2025-05-20 DOI: 10.1038/s41569-025-01170-x
Marta Catarina Almeida, Ricardo Fontes-Carvalho
{"title":"From data to impact: why conference presentation skills are essential for cardiovascular research dissemination","authors":"Marta Catarina Almeida,&nbsp;Ricardo Fontes-Carvalho","doi":"10.1038/s41569-025-01170-x","DOIUrl":"10.1038/s41569-025-01170-x","url":null,"abstract":"Conference presentation skills are a crucial, yet often overlooked, element in the dissemination of cardiovascular research. In an era of information overload and digital communication, the ability to clearly and engagingly present scientific data is essential, to ensure that the findings are understood, shared and implemented into clinical practice.","PeriodicalId":18976,"journal":{"name":"Nature Reviews Cardiology","volume":"22 7","pages":"459-460"},"PeriodicalIF":44.2,"publicationDate":"2025-05-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144096868","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Dual mechanotherapy for the treatment of cardiac fibrosis 双重机械疗法治疗心脏纤维化
IF 44.2 1区 医学
Nature Reviews Cardiology Pub Date : 2025-05-19 DOI: 10.1038/s41569-025-01172-9
Irene Fernández-Ruiz
{"title":"Dual mechanotherapy for the treatment of cardiac fibrosis","authors":"Irene Fernández-Ruiz","doi":"10.1038/s41569-025-01172-9","DOIUrl":"10.1038/s41569-025-01172-9","url":null,"abstract":"Inhibition of mechanotransduction selectively in cardiac fibrolasts, especially when combined with inhibition of transforming growth factor-β signalling, triggers a reversal of fibroblast activation and suppresses fibrosis in diseased hearts.","PeriodicalId":18976,"journal":{"name":"Nature Reviews Cardiology","volume":"22 7","pages":"465-465"},"PeriodicalIF":44.2,"publicationDate":"2025-05-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144096869","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
首页 上一页 下一页 尾页
0
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
提示
您的信息不完整，为了账户安全，请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
现在去查看 取消
×
提示
确定
请完成安全验证×
相关产品
×
本文献相关产品
联系我们：info@booksci.cn Book学术提供免费学术资源搜索服务，方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。 Copyright © 2023 布克学术 All rights reserved.
京ICP备2023020795号-1
ghs 京公网安备 11010802042870号
Book学术文献互助
Book学术文献互助群
群 号：604180095
Book学术官方微信