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Remuscularizing the failing heart in primates 灵长类动物衰竭心脏的再肌肉化
IF 41.7 1区 医学
Nature Reviews Cardiology Pub Date : 2025-02-10 DOI: 10.1038/s41569-025-01136-z
Gregory B. Lim
{"title":"Remuscularizing the failing heart in primates","authors":"Gregory B. Lim","doi":"10.1038/s41569-025-01136-z","DOIUrl":"10.1038/s41569-025-01136-z","url":null,"abstract":"Tissue engineered heart muscle implanted on to the epicardium can structurally and functionally remuscularize the failing hearts of rhesus macaques, with no major adverse effects; a clinical trial of this approach is now underway in patients with heart failure.","PeriodicalId":18976,"journal":{"name":"Nature Reviews Cardiology","volume":"22 4","pages":"221-221"},"PeriodicalIF":41.7,"publicationDate":"2025-02-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143375360","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Tracing the roots of cardiac fibrosis: role of endothelial-to-mesenchymal transition 追溯心脏纤维化的根源：内皮细胞向间质转化的作用
IF 49.6 1区 医学
Nature Reviews Cardiology Pub Date : 2025-02-07 DOI: 10.1038/s41569-025-01134-1
Elizabeth Figueroa-Juárez
{"title":"Tracing the roots of cardiac fibrosis: role of endothelial-to-mesenchymal transition","authors":"Elizabeth Figueroa-Juárez","doi":"10.1038/s41569-025-01134-1","DOIUrl":"https://doi.org/10.1038/s41569-025-01134-1","url":null,"abstract":"Elizabeth Figueroa-Juárez describes the study that demonstrated that fibroblasts derived from endothelial cells through endothelial-to-mesenchymal transition contribute to cardiac fibrosis.","PeriodicalId":18976,"journal":{"name":"Nature Reviews Cardiology","volume":"15 1","pages":""},"PeriodicalIF":49.6,"publicationDate":"2025-02-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143367371","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Novel pharmacological approaches to lowering blood pressure and managing hypertension 降低血压和控制高血压的新型药物疗法
IF 49.6 1区 医学
Nature Reviews Cardiology Pub Date : 2025-02-07 DOI: 10.1038/s41569-025-01131-4
Matthew Sayer, David J. Webb, Neeraj Dhaun
{"title":"Novel pharmacological approaches to lowering blood pressure and managing hypertension","authors":"Matthew Sayer, David J. Webb, Neeraj Dhaun","doi":"10.1038/s41569-025-01131-4","DOIUrl":"https://doi.org/10.1038/s41569-025-01131-4","url":null,"abstract":"<p>Hypertension is the leading cause of death globally, primarily due to its strong association with cardiovascular disease. The global prevalence of hypertension has surged over the past three decades, driven by rising rates of diabetes mellitus and obesity. Despite current antihypertensive therapies, only a small proportion of patients with hypertension achieve adequate blood pressure control, necessitating novel therapeutic strategies. In this Review we explore the challenges and emerging opportunities in hypertension management. Aprocitentan, a dual endothelin receptor antagonist, is the first agent from a novel class of antihypertensive drug to be licensed since 2007 and exemplifies innovative treatments on the horizon. Here we also address the complex factors contributing to poor hypertension control, including genetic influences, lifestyle factors, therapeutic inertia and poor patient adherence. We discuss the limitations of existing therapies and highlight promising new pharmacological approaches to hypertension management. Integrating these novel treatments alongside current pharmaceuticals combined with improved diagnostic and management strategies could substantially reduce the global burden of hypertension and associated cardiovascular disease.</p>","PeriodicalId":18976,"journal":{"name":"Nature Reviews Cardiology","volume":"55 1","pages":""},"PeriodicalIF":49.6,"publicationDate":"2025-02-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143367373","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Vagal circuits in the heart and gut can regulate cardiometabolism and stress responses 心脏和肠道中的迷走神经回路可以调节心脏代谢和应激反应
IF 41.7 1区 医学
Nature Reviews Cardiology Pub Date : 2025-02-07 DOI: 10.1038/s41569-025-01133-2
Karina Huynh
{"title":"Vagal circuits in the heart and gut can regulate cardiometabolism and stress responses","authors":"Karina Huynh","doi":"10.1038/s41569-025-01133-2","DOIUrl":"10.1038/s41569-025-01133-2","url":null,"abstract":"A new study shows that activation of vagal sensory neurons expressing the oxytocin receptor in the cardiovascular and gastrointestinal tissues of mice mediates cardiometabolic changes resembling those from a hibernation-like, hypometabolic state.","PeriodicalId":18976,"journal":{"name":"Nature Reviews Cardiology","volume":"22 4","pages":"220-220"},"PeriodicalIF":41.7,"publicationDate":"2025-02-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143258065","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Predictive cardio-omics: translating single-cell multiomics into tools for personalized medicine 预测性心脏组学：将单细胞多组学转化为个性化医疗的工具
IF 49.6 1区 医学
Nature Reviews Cardiology Pub Date : 2025-02-03 DOI: 10.1038/s41569-025-01132-3
Kami Pekayvaz, Matthias Heinig, Konstantin Stark
{"title":"Predictive cardio-omics: translating single-cell multiomics into tools for personalized medicine","authors":"Kami Pekayvaz, Matthias Heinig, Konstantin Stark","doi":"10.1038/s41569-025-01132-3","DOIUrl":"https://doi.org/10.1038/s41569-025-01132-3","url":null,"abstract":"In this Clinical Outlook, we describe available multiomic studies in cardiovascular medicine, discuss the advantages and potential of multiomic techniques for clinical translation in cardiology, and highlight three promising aspects: the generation of unprecedented cellular atlases, the identification of composite diagnostic and prognostic biomarkers derived from integrative multiomic signatures, and the isolation of potential therapeutic targets from unbiased comprehensive datasets and analyses.","PeriodicalId":18976,"journal":{"name":"Nature Reviews Cardiology","volume":"8 1","pages":""},"PeriodicalIF":49.6,"publicationDate":"2025-02-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143076932","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The molecular structure of LDL has finally been elucidated 低密度脂蛋白的分子结构终于被阐明
IF 49.6 1区 医学
Nature Reviews Cardiology Pub Date : 2025-01-28 DOI: 10.1038/s41569-025-01128-z
Gilles C. Lambert, Simon G. Pfisterer
{"title":"The molecular structure of LDL has finally been elucidated","authors":"Gilles C. Lambert, Simon G. Pfisterer","doi":"10.1038/s41569-025-01128-z","DOIUrl":"https://doi.org/10.1038/s41569-025-01128-z","url":null,"abstract":"Two studies published in Nature report the structure of apolipoprotein B100 on LDL using high-resolution, artificial intelligence-assisted cryo-electron microscopy and uncover its precise molecular interfaces with the LDL receptor. Dimers of LDL particles connected by a pair of receptors are also visualized for the first time. These studies provide key structural insights into the molecular defects linked to familial hypercholesterolaemia and open exciting avenues for translational research and drug development.","PeriodicalId":18976,"journal":{"name":"Nature Reviews Cardiology","volume":"47 1","pages":""},"PeriodicalIF":49.6,"publicationDate":"2025-01-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143050046","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Obesity alters cholesterol homeostasis in regulatory T cells of visceral adipose tissue 肥胖改变内脏脂肪组织调节性T细胞的胆固醇稳态
IF 41.7 1区 医学
Nature Reviews Cardiology Pub Date : 2025-01-28 DOI: 10.1038/s41569-025-01129-y
Irene Fernández-Ruiz
{"title":"Obesity alters cholesterol homeostasis in regulatory T cells of visceral adipose tissue","authors":"Irene Fernández-Ruiz","doi":"10.1038/s41569-025-01129-y","DOIUrl":"10.1038/s41569-025-01129-y","url":null,"abstract":"A new study shows how obesity can disrupt a cholesterol metabolism in a particular subset of metabolically protective regulatory T cells in visceral adipose tissue.","PeriodicalId":18976,"journal":{"name":"Nature Reviews Cardiology","volume":"22 3","pages":"146-146"},"PeriodicalIF":41.7,"publicationDate":"2025-01-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143050044","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Colchicine in acute coronary syndromes: the present and the possible future 秋水仙碱在急性冠状动脉综合征中的作用：现在和可能的未来
IF 41.7 1区 医学
Nature Reviews Cardiology Pub Date : 2025-01-28 DOI: 10.1038/s41569-025-01124-3
Massimo Imazio, Federico Ballacci, Federica Giordano
{"title":"Colchicine in acute coronary syndromes: the present and the possible future","authors":"Massimo Imazio,&nbsp;Federico Ballacci,&nbsp;Federica Giordano","doi":"10.1038/s41569-025-01124-3","DOIUrl":"10.1038/s41569-025-01124-3","url":null,"abstract":"Inflammation is a new therapeutic target for the prevention of cardiovascular disease. Colchicine is a potential cheap option to target inflammation and prevent atherosclerotic plaque destabilization. We discuss major clinical trials and guidelines on the use of colchicine in patients with coronary syndromes, especially acute coronary syndromes, in whom results have been conflicting.","PeriodicalId":18976,"journal":{"name":"Nature Reviews Cardiology","volume":"22 4","pages":"215-216"},"PeriodicalIF":41.7,"publicationDate":"2025-01-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143050043","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Anthracycline-induced cardiomyopathy: risk prediction, prevention and treatment 蒽环类药物引起的心肌病：风险预测、预防和治疗
IF 49.6 1区 医学
Nature Reviews Cardiology Pub Date : 2025-01-28 DOI: 10.1038/s41569-025-01126-1
Iacopo Fabiani, Michela Chianca, Carlo Maria Cipolla, Daniela Maria Cardinale
{"title":"Anthracycline-induced cardiomyopathy: risk prediction, prevention and treatment","authors":"Iacopo Fabiani, Michela Chianca, Carlo Maria Cipolla, Daniela Maria Cardinale","doi":"10.1038/s41569-025-01126-1","DOIUrl":"https://doi.org/10.1038/s41569-025-01126-1","url":null,"abstract":"<p>Anthracyclines are the cornerstone of treatment for many malignancies. However, anthracycline cardiotoxicity is a considerable concern given that it can compromise the clinical effectiveness of the treatment and patient survival despite early discontinuation of therapy or dose reduction. Patients with cancer receiving anthracycline treatment can have a reduction in their quality of life and likelihood of survival due to cardiotoxicity, irrespective of their oncological prognosis. Increasing knowledge about anthracycline cardiotoxicity has enabled the identification of patients who are candidates for anthracycline regimens and those who might develop anthracycline-induced cardiomyopathy. Anthracycline cardiotoxicity is a unique and evolving phenomenon that begins with myocardial cell damage, progresses to reduced left ventricular ejection fraction, and culminates in symptomatic heart failure if it is not promptly detected and treated. Early risk stratification can be guided by imaging or biomarkers. In this Review, we present a comprehensive and clinically useful approach to cardiomyopathy related to anthracycline therapy, encompassing its epidemiology, definition, mechanisms, novel classifications, risk factors and patient risk stratification, diagnostic approaches (including imaging and biomarkers), treatment guidelines algorithms, and the role of new cardioprotective drugs that are used for the treatment of heart failure.</p>","PeriodicalId":18976,"journal":{"name":"Nature Reviews Cardiology","volume":"22 1","pages":""},"PeriodicalIF":49.6,"publicationDate":"2025-01-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143050047","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The relationship between cannabis and cardiovascular disease: clearing the haze 大麻与心血管疾病的关系：清雾
IF 49.6 1区 医学
Nature Reviews Cardiology Pub Date : 2025-01-23 DOI: 10.1038/s41569-025-01121-6
Mark Chandy, Nerea Jimenez-Tellez, Joseph C. Wu
{"title":"The relationship between cannabis and cardiovascular disease: clearing the haze","authors":"Mark Chandy, Nerea Jimenez-Tellez, Joseph C. Wu","doi":"10.1038/s41569-025-01121-6","DOIUrl":"https://doi.org/10.1038/s41569-025-01121-6","url":null,"abstract":"<p>Cannabis has been consumed for centuries, but global regulatory changes over the past three decades have increased the availability and consumption of cannabis. Cannabinoids are touted to have therapeutic potential for many diseases and could be a replacement for opioids for analgesia and sedation. However, cannabinoids can cause substantial adverse cardiovascular events that would mitigate any potential benefit. The endocannabinoid system regulates mood, satiety and memory, and modulates the cardiovascular system. The link between cannabinoids and cardiovascular disease, which used to be limited to evidence from preclinical studies, case reports and case series, is now evident in epidemiological studies. Cannabinoids adversely affect the cardiovascular system, causing myocardial infarction, cerebrovascular accidents, arrhythmia and heart failure. The effects of novel cannabinoids are unknown, and synthetic cannabinoids have the potential to cause even more substantial harm than traditional cannabinoids. Therefore, with the increasing availability and use of cannabis, the acute and chronic effects of this drug are becoming apparent.</p>","PeriodicalId":18976,"journal":{"name":"Nature Reviews Cardiology","volume":"74 1","pages":""},"PeriodicalIF":49.6,"publicationDate":"2025-01-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143019989","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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