Nature Reviews Cardiology最新文献_第5页

Sleep and exercise can limit clonal haematopoiesis clone expansion and reduce associated atherosclerosis 睡眠和运动可以限制克隆造血克隆扩张，减少相关的动脉粥样硬化。

IF 50.2 1区医学

Nature Reviews Cardiology Pub Date : 2026-06-22 DOI: 10.1038/s41569-026-01318-3

Karina Huynh

引用次数: 0

Epigenetic regulation in atherosclerosis and its therapeutic potential. 动脉粥样硬化的表观遗传调控及其治疗潜力。

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Nature Reviews Cardiology Pub Date : 2026-06-19 DOI: 10.1038/s41569-026-01313-8

Donato Santovito, Dorothee Atzler, Christian Weber

{"title":"Epigenetic regulation in atherosclerosis and its therapeutic potential.","authors":"Donato Santovito, Dorothee Atzler, Christian Weber","doi":"10.1038/s41569-026-01313-8","DOIUrl":"https://doi.org/10.1038/s41569-026-01313-8","url":null,"abstract":"Atherosclerosis is the leading cause of cardiovascular morbidity and mortality worldwide. Beyond genetic predisposition, epigenetic mechanisms, such as DNA methylation, histone modifications and non-coding RNAs, have an integral role in the development, progression and complications of atherosclerosis. Global and locus-specific changes in DNA methylation regulate cell proliferation and inflammatory activation, whereas histone post-transcriptional modifications (primarily acetylation and methylation) regulate atherosclerosis-related gene networks relevant to lipid metabolism, cell plasticity and inflammation. Long non-coding RNAs further modulate vascular remodelling by shaping cell-specific transcriptomes and guiding epigenetic enzymes and their activity, whereas microRNAs exert post-transcriptional gene regulation and non-canonical functions. In this Review, we provide an overview of epigenetic regulation in atherosclerosis, focusing on how these dynamic, reversible modifications orchestrate gene expression in vascular endothelial cells, vascular smooth muscle cells and immune cells. We highlight how technological advances and the integration of multimodal datasets have progressed this research field and describe the cell-specific contributions of genetically associated loci. Finally, we discuss preclinical study findings and the translational efforts towards the development of epigenetic drugs as promising interventions to attenuate atherosclerotic plaque progression and inflammation, shedding light on the challenges of specificity, delivery and long-term safety. Achieving clinical applicability will enable precision medicine approaches to transform atherosclerosis therapy.","PeriodicalId":18976,"journal":{"name":"Nature Reviews Cardiology","volume":" ","pages":""},"PeriodicalIF":50.2,"publicationDate":"2026-06-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148283987","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Mitochondrial cardiomyopathy: bridging molecular mechanisms and clinical frontiers. 线粒体心肌病：连接分子机制和临床前沿。

IF 50.2 1区医学

Nature Reviews Cardiology Pub Date : 2026-06-18 DOI: 10.1038/s41569-026-01301-y

Atsuko Imai-Okazaki, Liming Pei, Douglas C Wallace

{"title":"Mitochondrial cardiomyopathy: bridging molecular mechanisms and clinical frontiers.","authors":"Atsuko Imai-Okazaki, Liming Pei, Douglas C Wallace","doi":"10.1038/s41569-026-01301-y","DOIUrl":"https://doi.org/10.1038/s41569-026-01301-y","url":null,"abstract":"Genetic cardiomyopathies caused by pathogenic variants in nuclear DNA (nDNA) that encodes contractile sarcomere proteins are among the best understood of all the cardiomyopathies. By contrast, mitochondrial cardiomyopathy is caused by a dysfunction in mitochondrial oxidative phosphorylation due to pathogenic variants in either nDNA or the maternal mitochondrial DNA (mtDNA). Unlike contractile protein defects, which generally follow predictable Mendelian inheritance patterns, mitochondrial cardiomyopathy is genetically complex as a result of the distinctive characteristics of the mitochondrial genome, which influence patterns of maternal inheritance, heteroplasmy and tissue-specific variations in mtDNA variant load. Both single-gene nDNA and mtDNA variants can impair cardiac energetics, resulting in a wide clinical spectrum ranging from severe, childhood-onset to milder, adult-onset cardiomyopathy. Furthermore, the intricate metabolic demands of the heart mean that mitochondrial dysfunction can be influenced by a broad array of genetic and environmental modifiers. A greater recognition of these complexities and the integration of genomic sequencing, novel biomarkers and functional imaging have advanced diagnostic and therapeutic approaches. Emerging treatment strategies, such as metabolic supplementation, gene therapy and genome editing, are under investigation. In this Review, we synthesize the molecular and clinical landscape of mitochondrial cardiomyopathy, highlighting the ongoing challenges and prospects of precision medicine in this rapidly evolving field.","PeriodicalId":18976,"journal":{"name":"Nature Reviews Cardiology","volume":" ","pages":""},"PeriodicalIF":50.2,"publicationDate":"2026-06-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148278127","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Climate change, food system disruption and future cardiometabolic disease burden 气候变化、粮食系统中断和未来的心脏代谢疾病负担。

IF 50.2 1区医学

Nature Reviews Cardiology Pub Date : 2026-06-18 DOI: 10.1038/s41569-026-01310-x

Gokul Parameswaran, Salil V. Deo, Sanjay Rajagopalan

引用次数: 0

Coronary artery calcium on chest CT scans: from incidental finding to mandatory reporting 胸部CT扫描冠状动脉钙化：从偶然发现到强制报告。

IF 50.2 1区医学

Nature Reviews Cardiology Pub Date : 2026-06-18 DOI: 10.1038/s41569-026-01317-4

Pierre Sabouret, Domenico Mario Giamundo, Luigi Sparafora, Stefano Figliozzi, Mamas A. Mamas, Giulio Stefanini, Elad Asher, Giuseppe Andò, Roger Blumenthal, Dan Atar

引用次数: 0

Role of systemic and epicardial adipose tissue in cardiometabolic disease. 全身和心外膜脂肪组织在心脏代谢疾病中的作用。

IF 50.2 1区医学

Nature Reviews Cardiology Pub Date : 2026-06-16 DOI: 10.1038/s41569-026-01304-9

Shaun Khanna, Gurkeerat Mann, Aditya Bhat, Andrew Lin, Anushka Patel, Stephen J Nicholls, Andrew Sindone, Damini Dey, Deepak L Bhatt, Clare Arnott, Thomas H Marwick, Nitesh Nerlekar

{"title":"Role of systemic and epicardial adipose tissue in cardiometabolic disease.","authors":"Shaun Khanna, Gurkeerat Mann, Aditya Bhat, Andrew Lin, Anushka Patel, Stephen J Nicholls, Andrew Sindone, Damini Dey, Deepak L Bhatt, Clare Arnott, Thomas H Marwick, Nitesh Nerlekar","doi":"10.1038/s41569-026-01304-9","DOIUrl":"10.1038/s41569-026-01304-9","url":null,"abstract":"Adipose tissue is increasingly recognized as an immunological and metabolic organ composed of multiple specialized depots that exert diverse effects on cardiometabolic health. Beyond total adiposity, the distribution and phenotypic state of regional adipose tissue depots, including visceral, subcutaneous and epicardial adipose tissue, contribute to shaping overall cardiovascular risk. These depots communicate with the vasculature and myocardium through endocrine, paracrine, vasocrine and neural pathways to mediate cardiovascular inflammation and remodelling. Advances in cardiac CT, MRI, dual-energy X-ray absorptiometry and artificial intelligence technologies in the past 5 years have resulted in highly reproducible measurements of adipose tissue volume, quality, density and radiomics. Emerging multiomics data now reveal how specific adipose tissue patterns correspond to pathways of inflammation and the development of cardiovascular disease. In this Review, we synthesize the current evidence across adipose depots, highlighting how their collective biology, more so than quantity alone, shapes cardiometabolic risk. Furthermore, we highlight emerging insights into adipose depot-specific biology, imaging phenotyping, ethnicity-related and sex-related differences, and potential therapeutic modulation. We also introduce the 'unified adipose tissue' model that conceptualizes all adipose tissue depots as components of a unified system, in which the biology rather than the total mass of adipose tissue drives cardiometabolic disease.","PeriodicalId":18976,"journal":{"name":"Nature Reviews Cardiology","volume":" ","pages":""},"PeriodicalIF":50.2,"publicationDate":"2026-06-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148265431","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Heart rate monitoring during everyday use of smartphones 每天使用智能手机时的心率监测。

IF 50.2 1区医学

Nature Reviews Cardiology Pub Date : 2026-06-15 DOI: 10.1038/s41569-026-01316-5

Gregory B. Lim

引用次数: 0

Promising results with stem-cell-derived tissue transplantation in heart failure 干细胞来源的组织移植治疗心力衰竭有希望的结果。

IF 50.2 1区医学

Nature Reviews Cardiology Pub Date : 2026-06-09 DOI: 10.1038/s41569-026-01315-6

Irene Fernández-Ruiz

引用次数: 0

The direction of cardiomyocyte growth is orchestrated by microtubule dynamics 心肌细胞的生长方向是由微管动力学调控的。