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The City Heartbeat Index as a benchmarking tool for urban cardiovascular health 城市心跳指数作为城市心血管健康的基准工具。
IF 44.2 1区 医学
Nature Reviews Cardiology Pub Date : 2026-03-03 DOI: 10.1038/s41569-026-01267-x
Amanda Stucke, Craig K. Cassidy, Anelia Boshnakova, Miranda Baxa, Alicia White, Amam Mbakwem, Borjana Pervan, Finn-Jarle Rode, Fausto Pinto, Daniel Pineiro, Jagat Narula
{"title":"The City Heartbeat Index as a benchmarking tool for urban cardiovascular health","authors":"Amanda Stucke, Craig K. Cassidy, Anelia Boshnakova, Miranda Baxa, Alicia White, Amam Mbakwem, Borjana Pervan, Finn-Jarle Rode, Fausto Pinto, Daniel Pineiro, Jagat Narula","doi":"10.1038/s41569-026-01267-x","DOIUrl":"10.1038/s41569-026-01267-x","url":null,"abstract":"Cities are dense population hubs where lifestyle, environmental and socioeconomic factors influence health outcomes, including morbidity and mortality secondary to cardiovascular disease. The City Heartbeat Index offers a city-level benchmarking framework that enables policy leaders to assess and implement the prevention and management of cardiovascular disease in urban environments.","PeriodicalId":18976,"journal":{"name":"Nature Reviews Cardiology","volume":"23 4","pages":"211-213"},"PeriodicalIF":44.2,"publicationDate":"2026-03-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147346346","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Author Correction: The effects of skeletal muscle and adipose tissue on outcomes in patients with heart failure 作者更正：骨骼肌和脂肪组织对心力衰竭患者预后的影响。
IF 44.2 1区 医学
Nature Reviews Cardiology Pub Date : 2026-03-02 DOI: 10.1038/s41569-026-01272-0
Wolfram Doehner, Henning T. Langer
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引用次数: 0
Understanding atrial failure: from diagnosis to clinical implications. 了解心房衰竭：从诊断到临床意义。
IF 44.2 1区 医学
Nature Reviews Cardiology Pub Date : 2026-02-27 DOI: 10.1038/s41569-026-01266-y
Bryce Alexander, Eugene Braunwald, Antoni Bayés-de-Luna, Aws Almufleh, Antoni Bayés-Genís, Adrian Baranchuk
{"title":"Understanding atrial failure: from diagnosis to clinical implications.","authors":"Bryce Alexander, Eugene Braunwald, Antoni Bayés-de-Luna, Aws Almufleh, Antoni Bayés-Genís, Adrian Baranchuk","doi":"10.1038/s41569-026-01266-y","DOIUrl":"https://doi.org/10.1038/s41569-026-01266-y","url":null,"abstract":"<p><p>Atrial failure is an emerging clinical syndrome that results from an underlying atrial cardiomyopathy and is characterized by impaired atrial haemodynamic and/or electrical function that is sufficient to cause symptoms, adverse clinical outcomes or both. Similar to ventricular cardiomyopathy, atrial cardiomyopathy refers to a structural, functional and/or electrophysiological tissue abnormality, whereas atrial failure denotes the stage at which it manifests clinically. Atrial failure can be classified as primary, when driven by intrinsic atrial pathology, or secondary, when atrial dysfunction arises from sustained haemodynamic or electrical stress imposed by ventricular, valvular or systemic disease. Increasing evidence indicates that atrial failure might not be merely a bystander, but a key determinant of symptoms and prognosis in cardiovascular conditions. Atrial failure can act as a primary driver of heart failure with preserved ejection fraction, promote atrial arrhythmias through adverse electrical remodelling, and potentially increase thromboembolic risk independently of atrial fibrillation. In this Review, we detail the pathophysiological mechanisms and clinical phenotypes of atrial failure and highlight the role of multimodality imaging in diagnosing and phenotyping atrial cardiomyopathy and clinical atrial failure. Finally, we summarize emerging therapeutic strategies aimed at potentially reversing atrial adverse remodelling and discuss future directions for integrating atrial failure into clinical practice.</p>","PeriodicalId":18976,"journal":{"name":"Nature Reviews Cardiology","volume":" ","pages":""},"PeriodicalIF":44.2,"publicationDate":"2026-02-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147317805","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The effects of skeletal muscle and adipose tissue on outcomes in patients with heart failure 骨骼肌和脂肪组织对心力衰竭患者预后的影响
IF 44.2 1区 医学
Nature Reviews Cardiology Pub Date : 2026-02-24 DOI: 10.1038/s41569-026-01268-w
Wolfram Doehner, Henning T. Langer
{"title":"The effects of skeletal muscle and adipose tissue on outcomes in patients with heart failure","authors":"Wolfram Doehner,&nbsp;Henning T. Langer","doi":"10.1038/s41569-026-01268-w","DOIUrl":"10.1038/s41569-026-01268-w","url":null,"abstract":"","PeriodicalId":18976,"journal":{"name":"Nature Reviews Cardiology","volume":"23 5","pages":"375-375"},"PeriodicalIF":44.2,"publicationDate":"2026-02-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147278710","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Reply to: ‘The effects of skeletal muscle and adipose tissue on outcomes in patients with heart failure’ 回复：“骨骼肌和脂肪组织对心力衰竭患者预后的影响”
IF 44.2 1区 医学
Nature Reviews Cardiology Pub Date : 2026-02-24 DOI: 10.1038/s41569-026-01270-2
Navin Suthahar
{"title":"Reply to: ‘The effects of skeletal muscle and adipose tissue on outcomes in patients with heart failure’","authors":"Navin Suthahar","doi":"10.1038/s41569-026-01270-2","DOIUrl":"10.1038/s41569-026-01270-2","url":null,"abstract":"","PeriodicalId":18976,"journal":{"name":"Nature Reviews Cardiology","volume":"23 5","pages":"376-377"},"PeriodicalIF":44.2,"publicationDate":"2026-02-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147278709","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
HFpEF and MASLD: converging mechanisms and clinical implications HFpEF和MASLD：会聚机制和临床意义
IF 49.6 1区 医学
Nature Reviews Cardiology Pub Date : 2026-02-24 DOI: 10.1038/s41569-026-01257-z
Federico Capone, Steffen P. Häseli, Luo Liu, Stefano Strocchi, Claudia Langenberg, Aldons J. Lusis, Maik Pietzner, Deborah M. Muoio, Oliver J. Rider, Betty Raman, Marat Fudim, Stefano Romeo, Yibin Wang, Mirko Völkers, Svati H. Shah, Gabriele G. Schiattarella
{"title":"HFpEF and MASLD: converging mechanisms and clinical implications","authors":"Federico Capone, Steffen P. Häseli, Luo Liu, Stefano Strocchi, Claudia Langenberg, Aldons J. Lusis, Maik Pietzner, Deborah M. Muoio, Oliver J. Rider, Betty Raman, Marat Fudim, Stefano Romeo, Yibin Wang, Mirko Völkers, Svati H. Shah, Gabriele G. Schiattarella","doi":"10.1038/s41569-026-01257-z","DOIUrl":"https://doi.org/10.1038/s41569-026-01257-z","url":null,"abstract":"","PeriodicalId":18976,"journal":{"name":"Nature Reviews Cardiology","volume":"25 1","pages":""},"PeriodicalIF":49.6,"publicationDate":"2026-02-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147278711","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Cardiotoxicity of T cell immunotherapies. T细胞免疫疗法的心脏毒性。
IF 44.2 1区 医学
Nature Reviews Cardiology Pub Date : 2026-02-23 DOI: 10.1038/s41569-026-01265-z
Michael A Raddatz, Ashley F Stein-Merlob, Syed S Mahmood, Sarju Ganatra, Daniel Addison, Tasha L Lin, Sarah M Larson, Eric H Yang
{"title":"Cardiotoxicity of T cell immunotherapies.","authors":"Michael A Raddatz, Ashley F Stein-Merlob, Syed S Mahmood, Sarju Ganatra, Daniel Addison, Tasha L Lin, Sarah M Larson, Eric H Yang","doi":"10.1038/s41569-026-01265-z","DOIUrl":"10.1038/s41569-026-01265-z","url":null,"abstract":"<p><p>T cell immunotherapies offer a new approach to cancer therapy. Chimeric antigen receptor (CAR) T cell therapy is the most prolific of these treatments, leveraging genetically engineered T cells to augment the antitumour response. Bispecific antibodies, T cell receptor-engineered T cells and tumour-infiltrating lymphocytes have also emerged as novel T cell therapies with therapeutic benefit. As the variety of T cell therapies and indications for their use expand, a nuanced understanding of potential haemodynamic sequelae and cardiovascular toxicities is required. T cell activation can lead to massive cytokine release and excessive inflammation, termed cytokine release syndrome (CRS). Like other inflammatory syndromes, CRS can lead to cardiovascular complications, including arrhythmias, myocardial infarction and heart failure, with an incidence of cardiovascular events as high as 20% among patients who develop high-grade CRS. In this Review, we summarize the mechanisms, epidemiology and management of T cell therapy-associated CRS and subsequent cardiotoxicity. We also explore how an improved understanding of CAR T cell therapy, and other emerging T cell-based treatments, will inform the prevention and management of adverse cardiovascular events.</p>","PeriodicalId":18976,"journal":{"name":"Nature Reviews Cardiology","volume":" ","pages":""},"PeriodicalIF":44.2,"publicationDate":"2026-02-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13043268/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147276930","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Invasive and medical management approaches to non-acute myocardial ischaemic syndromes 非急性心肌缺血综合征的侵入性和医学治疗方法
IF 49.6 1区 医学
Nature Reviews Cardiology Pub Date : 2026-02-19 DOI: 10.1038/s41569-026-01259-x
Nicholas Chiu, Deepak L. Bhatt, Raffaele De Caterina, Torsten Doenst, Hristo Kirov, Victor Dayan, David P. Faxon, Sanjay Kaul, Divaka Perera, John D. Puskas, Philippe Gabriel Steg, William E. Boden
{"title":"Invasive and medical management approaches to non-acute myocardial ischaemic syndromes","authors":"Nicholas Chiu, Deepak L. Bhatt, Raffaele De Caterina, Torsten Doenst, Hristo Kirov, Victor Dayan, David P. Faxon, Sanjay Kaul, Divaka Perera, John D. Puskas, Philippe Gabriel Steg, William E. Boden","doi":"10.1038/s41569-026-01259-x","DOIUrl":"https://doi.org/10.1038/s41569-026-01259-x","url":null,"abstract":"","PeriodicalId":18976,"journal":{"name":"Nature Reviews Cardiology","volume":"43 1","pages":""},"PeriodicalIF":49.6,"publicationDate":"2026-02-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146223159","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Neurovascular interactions in the ageing heart. 老化心脏中的神经血管相互作用。
IF 44.2 1区 医学
Nature Reviews Cardiology Pub Date : 2026-02-18 DOI: 10.1038/s41569-026-01260-4
Julian U G Wagner, Stefanie Dimmeler
{"title":"Neurovascular interactions in the ageing heart.","authors":"Julian U G Wagner, Stefanie Dimmeler","doi":"10.1038/s41569-026-01260-4","DOIUrl":"https://doi.org/10.1038/s41569-026-01260-4","url":null,"abstract":"<p><p>The global rise in life expectancy underscores the urgent need to extend healthspan and prevent age-related diseases. Cardiovascular disease is the leading cause of death worldwide, with ageing as a major non-modifiable risk factor. Ageing drives progressive vascular dysfunction and cardiac decline, including heart failure with preserved or reduced ejection fraction. Vascular cells are particularly vulnerable to ageing, resulting in structural and functional deterioration of the microvasculature and macrovasculature. Emerging evidence highlights that ageing also disrupts the neurovascular interface - an intricate axis between the nervous and vascular systems that governs cardiac function. Alterations to the neurovascular unit in the heart contribute to impaired autonomic regulation, increasing the risk of arrhythmias and heart failure. In this Review, we examine how neurovascular ageing shapes cardiac dysfunction and explore the therapeutic potential of targeting the cardiac neurovascular unit to mitigate cardiovascular ageing and promote resilience in ageing populations.</p>","PeriodicalId":18976,"journal":{"name":"Nature Reviews Cardiology","volume":" ","pages":""},"PeriodicalIF":44.2,"publicationDate":"2026-02-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146220543","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Mineralocorticoid antagonism in the treatment of heart failure 矿化皮质激素拮抗剂治疗心力衰竭。
IF 44.2 1区 医学
Nature Reviews Cardiology Pub Date : 2026-02-11 DOI: 10.1038/s41569-026-01261-3
Seamus J. Heanue, Morag J. Young
{"title":"Mineralocorticoid antagonism in the treatment of heart failure","authors":"Seamus J. Heanue,&nbsp;Morag J. Young","doi":"10.1038/s41569-026-01261-3","DOIUrl":"10.1038/s41569-026-01261-3","url":null,"abstract":"Seamus Heanue and Morag Young describe the work from Hans Selye that paved the way for the concept of mineralocorticoid receptor antagonists as therapy for heart failure.","PeriodicalId":18976,"journal":{"name":"Nature Reviews Cardiology","volume":"23 4","pages":"218-218"},"PeriodicalIF":44.2,"publicationDate":"2026-02-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146166195","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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