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Building the Australian Cardiovascular disease Data Commons 建立澳大利亚心血管疾病数据共享
IF 44.2 1区 医学
Nature Reviews Cardiology Pub Date : 2025-09-02 DOI: 10.1038/s41569-025-01208-0
Corey Giles, Peter J. Meikle
{"title":"Building the Australian Cardiovascular disease Data Commons","authors":"Corey Giles, Peter J. Meikle","doi":"10.1038/s41569-025-01208-0","DOIUrl":"10.1038/s41569-025-01208-0","url":null,"abstract":"In this Tools of the Trade article, Giles and Meikle describe the development of the the Australian Cardiovascular disease Data Commons, which provides a comprehensive, secure, scalable and internationally integrated database containing pooled data from approximately 400,000 individuals in Australia.","PeriodicalId":18976,"journal":{"name":"Nature Reviews Cardiology","volume":"22 11","pages":"837-837"},"PeriodicalIF":44.2,"publicationDate":"2025-09-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144928250","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Synthetic ion channel modulator reverses sodium channel dysfunction linked to cardiac arrhythmias 合成离子通道调节剂逆转与心律失常相关的钠通道功能障碍
IF 44.2 1区 医学
Nature Reviews Cardiology Pub Date : 2025-09-01 DOI: 10.1038/s41569-025-01207-1
Karina Huynh
{"title":"Synthetic ion channel modulator reverses sodium channel dysfunction linked to cardiac arrhythmias","authors":"Karina Huynh","doi":"10.1038/s41569-025-01207-1","DOIUrl":"10.1038/s41569-025-01207-1","url":null,"abstract":"Investigators of a new study published in Cell have engineered a new peptide modulator that binds to sodium channels to inhibit the late sodium current, which was shown to reverse the effects of sodium channel dysfunction associated with cardiac arrhythmias and epilepsy.","PeriodicalId":18976,"journal":{"name":"Nature Reviews Cardiology","volume":"22 11","pages":"839-839"},"PeriodicalIF":44.2,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144923936","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Creating an atlas of variant effects to resolve variants of uncertain significance and guide cardiovascular medicine 创建变异效应图谱，解决意义不确定的变异，指导心血管医学
IF 49.6 1区 医学
Nature Reviews Cardiology Pub Date : 2025-09-01 DOI: 10.1038/s41569-025-01201-7
Andrew M. Glazer, Daniel R. Tabet, Victoria N. Parikh, Brett M. Kroncke, Atina G. Cote, Yuta Yamamoto, Qianru Wang, Ayesha Muhammad, Megan C. Lancaster, Matthew J. O’Neill, Jochen Weile, Tao Yang, Calum A. Macrae, Euan A. Ashley, Frederick P. Roth, Dan M. Roden
{"title":"Creating an atlas of variant effects to resolve variants of uncertain significance and guide cardiovascular medicine","authors":"Andrew M. Glazer, Daniel R. Tabet, Victoria N. Parikh, Brett M. Kroncke, Atina G. Cote, Yuta Yamamoto, Qianru Wang, Ayesha Muhammad, Megan C. Lancaster, Matthew J. O’Neill, Jochen Weile, Tao Yang, Calum A. Macrae, Euan A. Ashley, Frederick P. Roth, Dan M. Roden","doi":"10.1038/s41569-025-01201-7","DOIUrl":"https://doi.org/10.1038/s41569-025-01201-7","url":null,"abstract":"<p>Cardiovascular diseases are leading global causes of death and disability, often presenting as interrelated phenotypes of atherosclerotic vascular disease, heart failure and arrhythmias. Cardiovascular diseases arise from interactions between environmental factors and predisposing genotypes and include common Mendelian lipid disorders, cardiomyopathies and arrhythmia syndromes. The identification of a pathogenic variant through genetic testing can inform disease diagnosis, risk prediction, treatment and family screening. However, a major roadblock in genomic medicine is that for many variants, especially missense variants, we lack sufficient evidence to enable a definitive classification, and therefore these variants are deemed as ‘variants of uncertain significance’. In this Review, we describe how multiplexed assays of variant effects can enable the functional assessment of nearly all coding variants in a target sequence, potentially offering a proactive approach to identifying the functional significance of gene variants that are observed later in a patient. We discuss validation, including the role of in silico variant effect predictors, and how multiplexed experimental methods are informing cardiovascular disease biology and ultimately resolving the problem of variants of uncertain significance at scale.</p>","PeriodicalId":18976,"journal":{"name":"Nature Reviews Cardiology","volume":"14 1","pages":""},"PeriodicalIF":49.6,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144928599","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
A deepening digital divide in cardiovascular disease management 心血管疾病管理中的数字鸿沟日益加深
IF 49.6 1区 医学
Nature Reviews Cardiology Pub Date : 2025-08-26 DOI: 10.1038/s41569-025-01206-2
Lu Yang, Abha Shrestha
{"title":"A deepening digital divide in cardiovascular disease management","authors":"Lu Yang, Abha Shrestha","doi":"10.1038/s41569-025-01206-2","DOIUrl":"https://doi.org/10.1038/s41569-025-01206-2","url":null,"abstract":"Lu Yang and Abha Shrestha revisit the first large-scale trial to investigate the effects of telemonitoring on heart failure outcomes and link the lessons learned from the trial to current digital health strategies and challenges.","PeriodicalId":18976,"journal":{"name":"Nature Reviews Cardiology","volume":"60 1","pages":""},"PeriodicalIF":49.6,"publicationDate":"2025-08-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144899201","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Overcoming difficulties with resilience 用韧性克服困难
IF 44.2 1区 医学
Nature Reviews Cardiology Pub Date : 2025-08-15 DOI: 10.1038/s41569-025-01202-6
Julia Grapsa
{"title":"Overcoming difficulties with resilience","authors":"Julia Grapsa","doi":"10.1038/s41569-025-01202-6","DOIUrl":"10.1038/s41569-025-01202-6","url":null,"abstract":"Difficulties, whether arising from work, academic or family environments, are a part of our life. A crucial part of our lives is our response to crisis and how we achieve resilience. In this sense, it is very important to try to turn negative experiences into positive&nbsp;—&nbsp;or at least constructive&nbsp;—&nbsp;experiences. In this Comment, I discuss how to achieve resilience in difficult times.","PeriodicalId":18976,"journal":{"name":"Nature Reviews Cardiology","volume":"22 11","pages":"833-834"},"PeriodicalIF":44.2,"publicationDate":"2025-08-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144851389","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Emerging AI tools for geospatially resolved cardiovascular risk 用于地理空间解决心血管风险的新兴人工智能工具。
IF 44.2 1区 医学
Nature Reviews Cardiology Pub Date : 2025-08-14 DOI: 10.1038/s41569-025-01204-4
Zhuo Chen, Jean Eudes Dazard, Salil Deo, Sadeer Al-Kindi, Sanjay Rajagopalan
{"title":"Emerging AI tools for geospatially resolved cardiovascular risk","authors":"Zhuo Chen,&nbsp;Jean Eudes Dazard,&nbsp;Salil Deo,&nbsp;Sadeer Al-Kindi,&nbsp;Sanjay Rajagopalan","doi":"10.1038/s41569-025-01204-4","DOIUrl":"10.1038/s41569-025-01204-4","url":null,"abstract":"Artificial intelligence (AI) technologies are revolutionizing cardiovascular health by analysing environmental factors at an unprecedented scale. Geospatial AI integrates vast datasets&nbsp;—&nbsp;from satellite imagery down to street-level views&nbsp;—&nbsp;to identify complex risk patterns, which enables personalized predictions and guides precision interventions to mitigate the environmental burden of disease.","PeriodicalId":18976,"journal":{"name":"Nature Reviews Cardiology","volume":"22 10","pages":"697-699"},"PeriodicalIF":44.2,"publicationDate":"2025-08-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144850847","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Hypertension in 2025: are we ready for bold precision public health approaches worldwide? 2025年的高血压：我们准备好在全球范围内采用大胆的精准公共卫生方法了吗？
IF 44.2 1区 医学
Nature Reviews Cardiology Pub Date : 2025-08-14 DOI: 10.1038/s41569-025-01192-5
Anna F. Dominiczak, Christian Delles
{"title":"Hypertension in 2025: are we ready for bold precision public health approaches worldwide?","authors":"Anna F. Dominiczak,&nbsp;Christian Delles","doi":"10.1038/s41569-025-01192-5","DOIUrl":"10.1038/s41569-025-01192-5","url":null,"abstract":"The latest developments in the field of hypertension have led to a better understanding of the pathophysiology of hypertension as well as to new pharmacological and device-based therapies and a wealth of clinical guidelines on prevention, diagnosis and treatment. To truly tackle the global epidemic of hypertension, we need a combination of pragmatic approaches and novel precision-medicine-based concepts.","PeriodicalId":18976,"journal":{"name":"Nature Reviews Cardiology","volume":"22 9","pages":"607-608"},"PeriodicalIF":44.2,"publicationDate":"2025-08-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144840038","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
A transformative preclinical model of rheumatic heart disease 风湿性心脏病的变革性临床前模型
IF 44.2 1区 医学
Nature Reviews Cardiology Pub Date : 2025-08-13 DOI: 10.1038/s41569-025-01203-5
Rukshan Ahamed Mohamed Rafeek, Natkunam Ketheesan
{"title":"A transformative preclinical model of rheumatic heart disease","authors":"Rukshan Ahamed Mohamed Rafeek,&nbsp;Natkunam Ketheesan","doi":"10.1038/s41569-025-01203-5","DOIUrl":"10.1038/s41569-025-01203-5","url":null,"abstract":"In this Tools of the Trade article, Rukshan Ahamed Mohamed Rafeek and Natkunam Ketheesan describe the utility of the Lewis rat autoimmune valvulitis model in assessing potential therapeutic applications for rheumatic heart disease.","PeriodicalId":18976,"journal":{"name":"Nature Reviews Cardiology","volume":"22 10","pages":"700-700"},"PeriodicalIF":44.2,"publicationDate":"2025-08-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144840043","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Artificial intelligence-enhanced echocardiography in cardiovascular disease management 人工智能增强超声心动图在心血管疾病管理中的应用
IF 49.6 1区 医学
Nature Reviews Cardiology Pub Date : 2025-08-05 DOI: 10.1038/s41569-025-01197-0
Peder L. Myhre, Bjørnar Grenne, Federico M. Asch, Victoria Delgado, Rohan Khera, Stéphane Lafitte, Roberto M. Lang, Patricia A. Pellikka, Partho P. Sengupta, Sreekanth Vemulapalli, Carolyn S. P. Lam
{"title":"Artificial intelligence-enhanced echocardiography in cardiovascular disease management","authors":"Peder L. Myhre, Bjørnar Grenne, Federico M. Asch, Victoria Delgado, Rohan Khera, Stéphane Lafitte, Roberto M. Lang, Patricia A. Pellikka, Partho P. Sengupta, Sreekanth Vemulapalli, Carolyn S. P. Lam","doi":"10.1038/s41569-025-01197-0","DOIUrl":"https://doi.org/10.1038/s41569-025-01197-0","url":null,"abstract":"<p>Artificial intelligence (AI) is transforming echocardiography, ushering in an era of improved diagnostic precision, efficiency and patient care. In this Review, we present an in-depth exploration of AI applications in echocardiography, highlighting the latest advances, practical implementations and future directions. We discuss the integration of AI throughout the echocardiographic workflow, from image acquisition and analysis to interpretation. We outline the potential of AI to automate routine measurements and calculations, enable task shifting, recognize disease-specific patterns and uncover new phenogroups that might surpass current diagnostic classifications. Moreover, we address the aspects needed to create trustworthy AI systems, through careful validation, navigating regulatory requirements and upholding ethical standards, thereby presenting a balanced perspective on the advantages and limitations of this rapidly evolving technology. Through an examination of current AI applications, clinical studies and technological breakthroughs, we offer a comprehensive understanding of the evolving role of AI in the future of echocardiography and its capacity to advance cardiovascular care, while also acknowledging the current limitations of the widespread clinical implementation of AI-supported echocardiography.</p>","PeriodicalId":18976,"journal":{"name":"Nature Reviews Cardiology","volume":"16 1","pages":""},"PeriodicalIF":49.6,"publicationDate":"2025-08-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144786628","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The gut metabolite imidazole propionate is a potential biomarker of and therapeutic target for atherosclerosis 肠道代谢物丙酸咪唑是动脉粥样硬化的潜在生物标志物和治疗靶点
IF 44.2 1区 医学
Nature Reviews Cardiology Pub Date : 2025-08-05 DOI: 10.1038/s41569-025-01200-8
Karina Huynh
{"title":"The gut metabolite imidazole propionate is a potential biomarker of and therapeutic target for atherosclerosis","authors":"Karina Huynh","doi":"10.1038/s41569-025-01200-8","DOIUrl":"10.1038/s41569-025-01200-8","url":null,"abstract":"According to a study published in Nature, the gut microbial metabolite imidazole propionate can induce atherosclerosis in atheroprone mice, further highlighting the role of microbiome-informed precision medicine to treat cardiovascular disease.","PeriodicalId":18976,"journal":{"name":"Nature Reviews Cardiology","volume":"22 10","pages":"701-701"},"PeriodicalIF":44.2,"publicationDate":"2025-08-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144778511","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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