Nature Reviews Cardiology最新文献

{"title":"Salt sensitivity of blood pressure: mechanisms and sex-specific differences","authors":"Sepiso K. Masenga, Nelson Wandira, Giuliana Cattivelli-Murdoch, Mohammad Saleem, Heather Beasley, Antentor Hinton, Lale A. Ertuglu, Naome Mwesigwa, Thomas R. Kleyman, Annet Kirabo","doi":"10.1038/s41569-025-01135-0","DOIUrl":"https://doi.org/10.1038/s41569-025-01135-0","url":null,"abstract":"<p>Salt sensitivity of blood pressure (SSBP) is an independent risk factor for cardiovascular disease in individuals with or without hypertension. However, the mechanisms and management of SSBP remain unclear, mainly because the diagnosis of this condition relies on salt loading–depletion protocols that are not feasible in the clinic. The prevalence of hypertension is lower in premenopausal women than in men, but this sex-specific difference is reversed after menopause. Whether excessive SSBP in women at any age contributes to this reversal is unknown, but many clinical studies that have rigorously assessed for SSBP using salt loading–depletion protocols have confirmed that SSBP is more prevalent in women than in men, including during premenopausal age. In this Review, we discuss sex-specific mechanisms of SSBP. We describe sex-related differences in renal transporters, hypertensive pregnancy, SSBP in autoimmune disorders and mitogen-activated protein kinase signalling pathways, and highlight limitations and lessons learned from Dahl salt-sensitive rat models.</p>","PeriodicalId":18976,"journal":{"name":"Nature Reviews Cardiology","volume":"81 1 1","pages":""},"PeriodicalIF":49.6,"publicationDate":"2025-02-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143462524","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Roadmap for alleviating the manifestations of ageing in the cardiovascular system","authors":"Luca Liberale, Simon Tual-Chalot, Simon Sedej, Stefano Ministrini, Georgios Georgiopoulos, Myriam Grunewald, Magnus Bäck, Marie-Luce Bochaton-Piallat, Reinier A. Boon, Gustavo Campos Ramos, Menno P. J. de Winther, Konstantinos Drosatos, Paul C. Evans, Jane F. Ferguson, Sofia K. Forslund-Startceva, Claudia Goettsch, Mauro Giacca, Judith Haendeler, Marinos Kallikourdis, Daniel F. J. Ketelhuth, Rory R. Koenen, Patrick Lacolley, Esther Lutgens, Pasquale Maffia, Satomi Miwa, Claudia Monaco, Fabrizio Montecucco, Giuseppe Danilo Norata, Elena Osto, Gavin D. Richardson, Niels P. Riksen, Oliver Soehnlein, Ioakim Spyridopoulos, Sophie Van Linthout, Gemma Vilahur, Jolanda J. Wentzel, Vicente Andrés, Lina Badimon, Athanase Benetos, Christoph J. Binder, Ralf P. Brandes, Filippo Crea, David Furman, Vera Gorbunova, Tomasz J. Guzik, Joseph A. Hill, Thomas F. Lüscher, María Mittelbrunn, Alessio Nencioni, Mihai G. Netea, João F. Passos, Kimon S. Stamatelopoulos, Nektarios Tavernarakis, Zoltan Ungvari, Joseph C. Wu, James L. Kirkland, Giovanni G. Camici, Stefanie Dimmeler, Guido Kroemer, Mahmoud Abdellatif, Konstantinos Stellos","doi":"10.1038/s41569-025-01130-5","DOIUrl":"https://doi.org/10.1038/s41569-025-01130-5","url":null,"abstract":"<p>Ageing of the cardiovascular system is associated with frailty and various life-threatening diseases. As global populations grow older, age-related conditions increasingly determine healthspan and lifespan. The circulatory system not only supplies nutrients and oxygen to all tissues of the human body and removes by-products but also builds the largest interorgan communication network, thereby serving as a gatekeeper for healthy ageing. Therefore, elucidating organ-specific and cell-specific ageing mechanisms that compromise circulatory system functions could have the potential to prevent or ameliorate age-related cardiovascular diseases. In support of this concept, emerging evidence suggests that targeting the circulatory system might restore organ function. In this Roadmap, we delve into the organ-specific and cell-specific mechanisms that underlie ageing-related changes in the cardiovascular system. We raise unanswered questions regarding the optimal design of clinical trials, in which markers of biological ageing in humans could be assessed. We provide guidance for the development of gerotherapeutics, which will rely on the technological progress of the diagnostic toolbox to measure residual risk in elderly individuals. A major challenge in the quest to discover interventions that delay age-related conditions in humans is to identify molecular switches that can delay the onset of ageing changes. To overcome this roadblock, future clinical trials need to provide evidence that gerotherapeutics directly affect one or several hallmarks of ageing in such a manner as to delay, prevent, alleviate or treat age-associated dysfunction and diseases.</p>","PeriodicalId":18976,"journal":{"name":"Nature Reviews Cardiology","volume":"85 1","pages":""},"PeriodicalIF":49.6,"publicationDate":"2025-02-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143451532","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Wearable blood pressure sensors for cardiovascular monitoring and machine learning algorithms for blood pressure estimation","authors":"Seongwook Min, Jaehun An, Jae Hee Lee, Ji Hoon Kim, Daniel J. Joe, Soo Hwan Eom, Chang D. Yoo, Hyo-Suk Ahn, Jin-Young Hwang, Sheng Xu, John A. Rogers, Keon Jae Lee","doi":"10.1038/s41569-025-01127-0","DOIUrl":"https://doi.org/10.1038/s41569-025-01127-0","url":null,"abstract":"<p>With advances in materials science and medical technology, wearable sensors have become crucial tools for the early diagnosis and continuous monitoring of numerous cardiovascular diseases, including arrhythmias, hypertension and coronary artery disease. These devices employ various sensing mechanisms, such as mechanoelectric, optoelectronic, ultrasonic and electrophysiological methods, to measure vital biosignals, including pulse rate, blood pressure and changes in heart rhythm. In this Review, we provide a comprehensive overview of the current state of wearable cardiovascular sensors, focusing particularly on those that measure blood pressure. We explore biosignal sensing principles, discuss blood pressure estimation methods (including machine learning algorithms) and summarize the latest advances in cuffless wearable blood pressure sensors. Finally, we highlight the challenges of and offer insights into potential pathways for the practical application of cuffless wearable blood pressure sensors in the medical field from both technical and clinical perspectives.</p>","PeriodicalId":18976,"journal":{"name":"Nature Reviews Cardiology","volume":"85 1","pages":""},"PeriodicalIF":49.6,"publicationDate":"2025-02-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143443168","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Clinical implications of perioperative and periprocedural myocardial infarction","authors":"Konstantin A. Krychtiuk, Christopher B. Granger, Bernard J. Gersh","doi":"10.1038/s41569-025-01137-y","DOIUrl":"https://doi.org/10.1038/s41569-025-01137-y","url":null,"abstract":"Differing definitions and questionable prognostic significance have caused confusion and controversy around the applicability of the current definitions of periprocedural and perioperative myocardial infarction in clinical practice. In this Clinical Outlook, we review the definitions and the clinical and prognostic relevance of the various entities and provide implications for clinical practice.","PeriodicalId":18976,"journal":{"name":"Nature Reviews Cardiology","volume":"61 1","pages":""},"PeriodicalIF":49.6,"publicationDate":"2025-02-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143393114","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Author Correction: Traction force microscopy of cardiomyocytes","authors":"Maia Lyall","doi":"10.1038/s41569-025-01139-w","DOIUrl":"https://doi.org/10.1038/s41569-025-01139-w","url":null,"abstract":"<p>Correction to: <i>Nature Reviews Cardiology</i> https://doi.org/10.1038/s41569-025-01123-4, published online 21 January 2025.</p>","PeriodicalId":18976,"journal":{"name":"Nature Reviews Cardiology","volume":"63 1","pages":""},"PeriodicalIF":49.6,"publicationDate":"2025-02-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143393568","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Remuscularizing the failing heart in primates","authors":"Gregory B. Lim","doi":"10.1038/s41569-025-01136-z","DOIUrl":"10.1038/s41569-025-01136-z","url":null,"abstract":"Tissue engineered heart muscle implanted on to the epicardium can structurally and functionally remuscularize the failing hearts of rhesus macaques, with no major adverse effects; a clinical trial of this approach is now underway in patients with heart failure.","PeriodicalId":18976,"journal":{"name":"Nature Reviews Cardiology","volume":"22 4","pages":"221-221"},"PeriodicalIF":41.7,"publicationDate":"2025-02-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143375360","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Tracing the roots of cardiac fibrosis: role of endothelial-to-mesenchymal transition","authors":"Elizabeth Figueroa-Juárez","doi":"10.1038/s41569-025-01134-1","DOIUrl":"https://doi.org/10.1038/s41569-025-01134-1","url":null,"abstract":"Elizabeth Figueroa-Juárez describes the study that demonstrated that fibroblasts derived from endothelial cells through endothelial-to-mesenchymal transition contribute to cardiac fibrosis.","PeriodicalId":18976,"journal":{"name":"Nature Reviews Cardiology","volume":"15 1","pages":""},"PeriodicalIF":49.6,"publicationDate":"2025-02-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143367371","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Novel pharmacological approaches to lowering blood pressure and managing hypertension","authors":"Matthew Sayer, David J. Webb, Neeraj Dhaun","doi":"10.1038/s41569-025-01131-4","DOIUrl":"https://doi.org/10.1038/s41569-025-01131-4","url":null,"abstract":"<p>Hypertension is the leading cause of death globally, primarily due to its strong association with cardiovascular disease. The global prevalence of hypertension has surged over the past three decades, driven by rising rates of diabetes mellitus and obesity. Despite current antihypertensive therapies, only a small proportion of patients with hypertension achieve adequate blood pressure control, necessitating novel therapeutic strategies. In this Review we explore the challenges and emerging opportunities in hypertension management. Aprocitentan, a dual endothelin receptor antagonist, is the first agent from a novel class of antihypertensive drug to be licensed since 2007 and exemplifies innovative treatments on the horizon. Here we also address the complex factors contributing to poor hypertension control, including genetic influences, lifestyle factors, therapeutic inertia and poor patient adherence. We discuss the limitations of existing therapies and highlight promising new pharmacological approaches to hypertension management. Integrating these novel treatments alongside current pharmaceuticals combined with improved diagnostic and management strategies could substantially reduce the global burden of hypertension and associated cardiovascular disease.</p>","PeriodicalId":18976,"journal":{"name":"Nature Reviews Cardiology","volume":"55 1","pages":""},"PeriodicalIF":49.6,"publicationDate":"2025-02-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143367373","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Vagal circuits in the heart and gut can regulate cardiometabolism and stress responses","authors":"Karina Huynh","doi":"10.1038/s41569-025-01133-2","DOIUrl":"10.1038/s41569-025-01133-2","url":null,"abstract":"A new study shows that activation of vagal sensory neurons expressing the oxytocin receptor in the cardiovascular and gastrointestinal tissues of mice mediates cardiometabolic changes resembling those from a hibernation-like, hypometabolic state.","PeriodicalId":18976,"journal":{"name":"Nature Reviews Cardiology","volume":"22 4","pages":"220-220"},"PeriodicalIF":41.7,"publicationDate":"2025-02-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143258065","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Predictive cardio-omics: translating single-cell multiomics into tools for personalized medicine","authors":"Kami Pekayvaz, Matthias Heinig, Konstantin Stark","doi":"10.1038/s41569-025-01132-3","DOIUrl":"https://doi.org/10.1038/s41569-025-01132-3","url":null,"abstract":"In this Clinical Outlook, we describe available multiomic studies in cardiovascular medicine, discuss the advantages and potential of multiomic techniques for clinical translation in cardiology, and highlight three promising aspects: the generation of unprecedented cellular atlases, the identification of composite diagnostic and prognostic biomarkers derived from integrative multiomic signatures, and the isolation of potential therapeutic targets from unbiased comprehensive datasets and analyses.","PeriodicalId":18976,"journal":{"name":"Nature Reviews Cardiology","volume":"8 1","pages":""},"PeriodicalIF":49.6,"publicationDate":"2025-02-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143076932","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}