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Nature Reviews Cardiology最新文献

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The renaissance of cardiac glycosides in heart failure: why, for whom and when 心脏糖苷在心力衰竭中的复兴：为什么，为谁，何时
IF 50.2 1区 医学
Nature Reviews Cardiology Pub Date : 2026-07-17 DOI: 10.1038/s41569-026-01323-6
Antonio Cannata, Theresa A. McDonagh
{"title":"The renaissance of cardiac glycosides in heart failure: why, for whom and when","authors":"Antonio Cannata, Theresa A. McDonagh","doi":"10.1038/s41569-026-01323-6","DOIUrl":"10.1038/s41569-026-01323-6","url":null,"abstract":"Cardiac glycosides were the cornerstone of heart failure treatment for decades, but their use progressively declined after the introduction of modern prognostic medications. Two clinical trials now report that cardiac glycosides can reduce the risk of worsening heart failure events in patients with heart failure with reduced ejection fraction. These results do not mandate a paradigm shift but support a specific role for cardiac glycosides in selected patients.","PeriodicalId":18976,"journal":{"name":"Nature Reviews Cardiology","volume":"23 9","pages":"615-616"},"PeriodicalIF":50.2,"publicationDate":"2026-07-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148459620","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
YAP at the heart of cardiac regeneration YAP是心脏再生的核心
IF 49.6 1区 医学
Nature Reviews Cardiology Pub Date : 2026-07-16 DOI: 10.1038/s41569-026-01328-1
Ghulam Mehdi Dar
{"title":"YAP at the heart of cardiac regeneration","authors":"Ghulam Mehdi Dar","doi":"10.1038/s41569-026-01328-1","DOIUrl":"https://doi.org/10.1038/s41569-026-01328-1","url":null,"abstract":"","PeriodicalId":18976,"journal":{"name":"Nature Reviews Cardiology","volume":"11 1","pages":""},"PeriodicalIF":49.6,"publicationDate":"2026-07-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148459621","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
In the era of AI, omics and organoids, animal models are still needed in cardiovascular research 在人工智能、组学和类器官时代，心血管研究仍然需要动物模型
IF 49.6 1区 医学
Nature Reviews Cardiology Pub Date : 2026-07-14 DOI: 10.1038/s41569-026-01327-2
Petra Kleinbongard, Bruno K. Podesser, Gemma Vilahur, Christoph Maack, Dunja Aksentijevic
{"title":"In the era of AI, omics and organoids, animal models are still needed in cardiovascular research","authors":"Petra Kleinbongard, Bruno K. Podesser, Gemma Vilahur, Christoph Maack, Dunja Aksentijevic","doi":"10.1038/s41569-026-01327-2","DOIUrl":"https://doi.org/10.1038/s41569-026-01327-2","url":null,"abstract":"","PeriodicalId":18976,"journal":{"name":"Nature Reviews Cardiology","volume":"323 1","pages":""},"PeriodicalIF":49.6,"publicationDate":"2026-07-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148432041","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
World Heart Federation Roadmap on cardiac rehabilitation: a pathway to lifelong cardiovascular health 世界心脏联合会心脏康复路线图：通往终身心血管健康的途径
IF 49.6 1区 医学
Nature Reviews Cardiology Pub Date : 2026-07-13 DOI: 10.1038/s41569-026-01312-9
Julie Redfern, Randal J. Thomas, Tom Briffa, Lilian Mbau, Robyn Gallagher, Dion Candelaria, Irene Gibson, Wen-Chih Wu, Alexis Beatty, Gabriela L. M. Ghisi, Alice Namanja, Dawn Scantlebury, Abraham Samuel Babu, Giulliano Gardenghi, Yihong Sun, Aashish Contractor, Ana Abreu, Roque Daniel González, Pat O’Donnell, Rongjing Ding, David Wood, Sidney C. Smith
{"title":"World Heart Federation Roadmap on cardiac rehabilitation: a pathway to lifelong cardiovascular health","authors":"Julie Redfern, Randal J. Thomas, Tom Briffa, Lilian Mbau, Robyn Gallagher, Dion Candelaria, Irene Gibson, Wen-Chih Wu, Alexis Beatty, Gabriela L. M. Ghisi, Alice Namanja, Dawn Scantlebury, Abraham Samuel Babu, Giulliano Gardenghi, Yihong Sun, Aashish Contractor, Ana Abreu, Roque Daniel González, Pat O’Donnell, Rongjing Ding, David Wood, Sidney C. Smith","doi":"10.1038/s41569-026-01312-9","DOIUrl":"https://doi.org/10.1038/s41569-026-01312-9","url":null,"abstract":"","PeriodicalId":18976,"journal":{"name":"Nature Reviews Cardiology","volume":"22 1","pages":""},"PeriodicalIF":49.6,"publicationDate":"2026-07-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148432042","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Transfer of a gain-of-function PCSK9 gene to induce atherosclerosis in mice. 功能获得性PCSK9基因的转移诱导小鼠动脉粥样硬化。
IF 49.6 1区 医学
Nature Reviews Cardiology Pub Date : 2026-07-08 DOI: 10.1038/s41569-026-01326-3
Julián Albarrán-Juárez
{"title":"Transfer of a gain-of-function PCSK9 gene to induce atherosclerosis in mice.","authors":"Julián Albarrán-Juárez","doi":"10.1038/s41569-026-01326-3","DOIUrl":"https://doi.org/10.1038/s41569-026-01326-3","url":null,"abstract":"","PeriodicalId":18976,"journal":{"name":"Nature Reviews Cardiology","volume":"111 1","pages":""},"PeriodicalIF":49.6,"publicationDate":"2026-07-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148408041","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Sarcomere dysfunction as the molecular basis of hypertrophic cardiomyopathy. 肌节功能障碍是肥厚性心肌病的分子基础。
IF 49.6 1区 医学
Nature Reviews Cardiology Pub Date : 2026-07-08 DOI: 10.1038/s41569-026-01324-5
Saif F Dababneh,Thomas M Roston
{"title":"Sarcomere dysfunction as the molecular basis of hypertrophic cardiomyopathy.","authors":"Saif F Dababneh,Thomas M Roston","doi":"10.1038/s41569-026-01324-5","DOIUrl":"https://doi.org/10.1038/s41569-026-01324-5","url":null,"abstract":"","PeriodicalId":18976,"journal":{"name":"Nature Reviews Cardiology","volume":"34 1","pages":""},"PeriodicalIF":49.6,"publicationDate":"2026-07-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148408040","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Epidemiology and determinants of cardiovascular disease in Indigenous populations. 土著居民心血管疾病的流行病学和决定因素。
IF 49.6 1区 医学
Nature Reviews Cardiology Pub Date : 2026-07-07 DOI: 10.1038/s41569-026-01314-7
Katharine Frances Brown,Victor M Oguoma,Anna Rolleston,Corina Grey,Jason F Deen,Donald Warne,Peter Azzopardi,Jeffrey Reading,Alex Brown
{"title":"Epidemiology and determinants of cardiovascular disease in Indigenous populations.","authors":"Katharine Frances Brown,Victor M Oguoma,Anna Rolleston,Corina Grey,Jason F Deen,Donald Warne,Peter Azzopardi,Jeffrey Reading,Alex Brown","doi":"10.1038/s41569-026-01314-7","DOIUrl":"https://doi.org/10.1038/s41569-026-01314-7","url":null,"abstract":"This Review describes the burden of cardiovascular disease across Indigenous populations and contextualizes the potential drivers and contributors to inequalities between Indigenous and non-Indigenous populations. The focus is on Indigenous populations across Aotearoa New Zealand, Australia, Canada and the USA, including Aboriginal and Torres Strait Islander, American Indian, Alaska Native, Canadian First Nations, Inuit, Métis, Māori, Native Hawaiian and Pacific Islander peoples. Available data show that cardiovascular disease is a leading cause of premature and excess disease burden for Indigenous populations, characterized by excess mortality, morbidity and related health-care utilization. Inequities emerge early in the life course, in adolescence and young adulthood. However, the availability of data from Indigenous populations in each country is severely limited, highlighting the need for comprehensive research and collection of administrative data to enable surveillance, monitor secular trends in inequality, and identify targets for policy and health-system reform. This Review posits the complex interplay between determinants of cardiovascular disease, incorporating intergenerational socioeconomic disadvantage, structural discrimination and racism, and the way in which colonization increases exposure to risks, contributing to the erosion of cultural strengths and cardioprotective factors. These determinants represent key targets for preventative and promotive action to improve and sustain the cardiovascular wellbeing of Indigenous populations.","PeriodicalId":18976,"journal":{"name":"Nature Reviews Cardiology","volume":"163 1","pages":""},"PeriodicalIF":49.6,"publicationDate":"2026-07-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148400751","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The origin of clinical left ventricular ejection fraction measurement 临床左室射血分数测定的起源。
IF 50.2 1区 医学
Nature Reviews Cardiology Pub Date : 2026-07-03 DOI: 10.1038/s41569-026-01321-8
Stephe Kamalathasan, Sam Straw
{"title":"The origin of clinical left ventricular ejection fraction measurement","authors":"Stephe Kamalathasan, Sam Straw","doi":"10.1038/s41569-026-01321-8","DOIUrl":"10.1038/s41569-026-01321-8","url":null,"abstract":"The authors highlight the first report of the measurement of left ventricular ejection fraction in humans, published in 1962 by Roland Folse and Eugene Braunwald.","PeriodicalId":18976,"journal":{"name":"Nature Reviews Cardiology","volume":"23 9","pages":"618-618"},"PeriodicalIF":50.2,"publicationDate":"2026-07-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148379953","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Inclusive cardiovascular care for sexual and gender minority populations 针对性和性别少数人群的包容性心血管护理。
IF 50.2 1区 医学
Nature Reviews Cardiology Pub Date : 2026-06-26 DOI: 10.1038/s41569-026-01320-9
Ian K. Everitt, Colleen M. Harrington, Monica Mukherjee, Carl G. Streed Jr
{"title":"Inclusive cardiovascular care for sexual and gender minority populations","authors":"Ian K. Everitt, Colleen M. Harrington, Monica Mukherjee, Carl G. Streed Jr","doi":"10.1038/s41569-026-01320-9","DOIUrl":"10.1038/s41569-026-01320-9","url":null,"abstract":"Guidance is limited on how to move beyond the recognition of disparities in cardiovascular care among sexual and gender minority (SGM) adults towards scalable health-care delivery that both supports risk assessment for and improves prevention of cardiovascular disease. We propose key components of cardiovascular programmes for SGM adults, including clinical scope, multidisciplinary health-care teams, SGM-specific considerations and measurable quality outcomes.","PeriodicalId":18976,"journal":{"name":"Nature Reviews Cardiology","volume":"23 9","pages":"609-611"},"PeriodicalIF":50.2,"publicationDate":"2026-06-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148335974","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Modular cardiac microtissues for interrogating cell-type contributions 用于询问细胞类型贡献的模块化心脏显微组织。
IF 50.2 1区 医学
Nature Reviews Cardiology Pub Date : 2026-06-24 DOI: 10.1038/s41569-026-01319-2
Jarmon G. Lees, Shiang Y. Lim
{"title":"Modular cardiac microtissues for interrogating cell-type contributions","authors":"Jarmon G. Lees, Shiang Y. Lim","doi":"10.1038/s41569-026-01319-2","DOIUrl":"10.1038/s41569-026-01319-2","url":null,"abstract":"In this Tools of the Trade article, Lees and Lim describe a human modular cardiac microtissue platform used in their research laboratory that allows the contribution of each cell type to be established within an otherwise-intact human engineered cardiac tissue.","PeriodicalId":18976,"journal":{"name":"Nature Reviews Cardiology","volume":"23 9","pages":"617-617"},"PeriodicalIF":50.2,"publicationDate":"2026-06-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148313369","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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