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Minority stress, discrimination and cardiovascular health 少数群体的压力、歧视和心血管健康
IF 49.6 1区 医学
Nature Reviews Cardiology Pub Date : 2024-09-24 DOI: 10.1038/s41569-024-01083-1
John C. Lin, Dang Nguyen, Anthony Zhong
{"title":"Minority stress, discrimination and cardiovascular health","authors":"John C. Lin, Dang Nguyen, Anthony Zhong","doi":"10.1038/s41569-024-01083-1","DOIUrl":"https://doi.org/10.1038/s41569-024-01083-1","url":null,"abstract":"John C. Lin and colleagues explore the history of racial disparities in cardiovascular outcomes and discuss the landmark findings of the CARDIA study and its contribution to the minority stress model.","PeriodicalId":18976,"journal":{"name":"Nature Reviews Cardiology","volume":"39 1","pages":""},"PeriodicalIF":49.6,"publicationDate":"2024-09-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142313848","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
20 years of Nature Reviews Cardiology 自然-心脏病学评论》20 周年
IF 41.7 1区 医学
Nature Reviews Cardiology Pub Date : 2024-09-24 DOI: 10.1038/s41569-024-01090-2
{"title":"20 years of Nature Reviews Cardiology","authors":"","doi":"10.1038/s41569-024-01090-2","DOIUrl":"10.1038/s41569-024-01090-2","url":null,"abstract":"The 20th anniversary of Nature Reviews Cardiology comes at a time of exciting innovation for cardiovascular research and clinical cardiology, with the advent of nucleic acid-targeted therapeutics, applications of artificial intelligence, promotion of a healthy cardiovascular exposome, personalization of medicine, and recognition of the importance of diversity, equity and inclusion in health care.","PeriodicalId":18976,"journal":{"name":"Nature Reviews Cardiology","volume":"21 11","pages":"735-736"},"PeriodicalIF":41.7,"publicationDate":"2024-09-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.nature.com/articles/s41569-024-01090-2.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142313849","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Cryo-X-ray phase contrast imaging for 3D structural and molecular analysis of frozen biopsy samples 用于冷冻活检样本三维结构和分子分析的低温 X 射线相衬成像技术
IF 41.7 1区 医学
Nature Reviews Cardiology Pub Date : 2024-09-23 DOI: 10.1038/s41569-024-01084-0
Kan Yan Chloe Li, Anne Bonnin
{"title":"Cryo-X-ray phase contrast imaging for 3D structural and molecular analysis of frozen biopsy samples","authors":"Kan Yan Chloe Li, Anne Bonnin","doi":"10.1038/s41569-024-01084-0","DOIUrl":"10.1038/s41569-024-01084-0","url":null,"abstract":"In this Tools of the Trade article, Li and Bonnin describe the use of cryo-X-ray phase contrast imaging to assess frozen myocardial biopsy samples.","PeriodicalId":18976,"journal":{"name":"Nature Reviews Cardiology","volume":"21 12","pages":"845-845"},"PeriodicalIF":41.7,"publicationDate":"2024-09-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142276869","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The molecular landscape of vascular cells in the human brain 人脑中血管细胞的分子结构。
IF 41.7 1区 医学
Nature Reviews Cardiology Pub Date : 2024-09-20 DOI: 10.1038/s41569-024-01079-x
Elizabeth E. Crouch
{"title":"The molecular landscape of vascular cells in the human brain","authors":"Elizabeth E. Crouch","doi":"10.1038/s41569-024-01079-x","DOIUrl":"10.1038/s41569-024-01079-x","url":null,"abstract":"A study using advanced single-cell technologies has broadened our understanding of the diversity and complexity of brain endothelial cells by uncovering new endothelial subtypes and transcriptional patterns. These findings offer insights into potential therapeutic targets and emphasize the need for further research on vascular lineages and neurovascular interactions.","PeriodicalId":18976,"journal":{"name":"Nature Reviews Cardiology","volume":"21 12","pages":"847-848"},"PeriodicalIF":41.7,"publicationDate":"2024-09-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142275211","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Lysosomes in the immunometabolic reprogramming of immune cells in atherosclerosis. 溶酶体在动脉粥样硬化免疫细胞免疫代谢重编程中的作用。
IF 49.6 1区 医学
Nature Reviews Cardiology Pub Date : 2024-09-20 DOI: 10.1038/s41569-024-01072-4
Fabrizia Bonacina,Xiangyu Zhang,Nicolas Manel,Laurent Yvan-Charvet,Babak Razani,Giuseppe D Norata
{"title":"Lysosomes in the immunometabolic reprogramming of immune cells in atherosclerosis.","authors":"Fabrizia Bonacina,Xiangyu Zhang,Nicolas Manel,Laurent Yvan-Charvet,Babak Razani,Giuseppe D Norata","doi":"10.1038/s41569-024-01072-4","DOIUrl":"https://doi.org/10.1038/s41569-024-01072-4","url":null,"abstract":"Lysosomes have a central role in the disposal of extracellular and intracellular cargo and also function as metabolic sensors and signalling platforms in the immunometabolic reprogramming of macrophages and other immune cells in atherosclerosis. Lysosomes can rapidly sense the presence of nutrients within immune cells, thereby switching from catabolism of extracellular material to the recycling of intracellular cargo. Such a fine-tuned degradative response supports the generation of metabolic building blocks through effectors such as mTORC1 or TFEB. By coupling nutrients to downstream signalling and metabolism, lysosomes serve as a crucial hub for cellular function in innate and adaptive immune cells. Lysosomal dysfunction is now recognized to be a hallmark of atherogenesis. Perturbations in nutrient-sensing and signalling have profound effects on the capacity of immune cells to handle cholesterol, perform phagocytosis and efferocytosis, and limit the activation of the inflammasome and other inflammatory pathways. Strategies to improve lysosomal function hold promise as novel modulators of the immunoinflammatory response associated with atherosclerosis. In this Review, we describe the crosstalk between lysosomal biology and immune cell function and polarization, with a particular focus on cellular immunometabolic reprogramming in the context of atherosclerosis.","PeriodicalId":18976,"journal":{"name":"Nature Reviews Cardiology","volume":"204 1","pages":""},"PeriodicalIF":49.6,"publicationDate":"2024-09-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142275210","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Finerenone improves outcomes in HFmrEF and HFpEF 非格列酮能改善高房颤mrEF和高房颤pEF的预后
IF 41.7 1区 医学
Nature Reviews Cardiology Pub Date : 2024-09-19 DOI: 10.1038/s41569-024-01087-x
Irene Fernández-Ruiz
{"title":"Finerenone improves outcomes in HFmrEF and HFpEF","authors":"Irene Fernández-Ruiz","doi":"10.1038/s41569-024-01087-x","DOIUrl":"10.1038/s41569-024-01087-x","url":null,"abstract":"The non-steroidal mineralocorticoid receptor antagonist finerenone reduces the risk of adverse outcomes in patients with heart failure with mildly reduced ejection fraction or with preserved ejection fraction, according to findings presented at the ESC Congress 2024.","PeriodicalId":18976,"journal":{"name":"Nature Reviews Cardiology","volume":"21 11","pages":"739-739"},"PeriodicalIF":41.7,"publicationDate":"2024-09-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142245408","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
TEER is non-inferior to surgery in patients with secondary mitral regurgitation 在继发性二尖瓣反流患者中，TEER 的疗效并不优于手术治疗
IF 41.7 1区 医学
Nature Reviews Cardiology Pub Date : 2024-09-19 DOI: 10.1038/s41569-024-01089-9
Irene Fernández-Ruiz
{"title":"TEER is non-inferior to surgery in patients with secondary mitral regurgitation","authors":"Irene Fernández-Ruiz","doi":"10.1038/s41569-024-01089-9","DOIUrl":"10.1038/s41569-024-01089-9","url":null,"abstract":"In patients with heart failure and secondary mitral valve regurgitation, transcatheter edge-to-edge repair is non-inferior to mitral valve surgery with respect to a composite of death, hospitalization for heart failure, reintervention, implantation of an assist device or stroke at 1 year after the procedure, according to findings from the MATTERHORN trial.","PeriodicalId":18976,"journal":{"name":"Nature Reviews Cardiology","volume":"21 11","pages":"742-742"},"PeriodicalIF":41.7,"publicationDate":"2024-09-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142245401","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Combining TAVI with PCI in patients with aortic stenosis and CAD 在主动脉瓣狭窄和 CAD 患者中将 TAVI 与 PCI 结合使用
IF 41.7 1区 医学
Nature Reviews Cardiology Pub Date : 2024-09-19 DOI: 10.1038/s41569-024-01080-4
Gregory B. Lim
{"title":"Combining TAVI with PCI in patients with aortic stenosis and CAD","authors":"Gregory B. Lim","doi":"10.1038/s41569-024-01080-4","DOIUrl":"10.1038/s41569-024-01080-4","url":null,"abstract":"In the NOTION-3 trial, percutaneous coronary intervention reduced the occurrence of major adverse cardiac events compared with conservative treatment in patients who were undergoing transcatheter aortic valve implantation for severe aortic stenosis and who had stable coronary artery disease.","PeriodicalId":18976,"journal":{"name":"Nature Reviews Cardiology","volume":"21 11","pages":"742-742"},"PeriodicalIF":41.7,"publicationDate":"2024-09-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142245407","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Benefit of vutrisiran in transthyretin amyloidosis with cardiomyopathy 经甲状腺素淀粉样变性伴心肌病患者服用武曲地兰的益处
IF 41.7 1区 医学
Nature Reviews Cardiology Pub Date : 2024-09-19 DOI: 10.1038/s41569-024-01086-y
Gregory B. Lim
{"title":"Benefit of vutrisiran in transthyretin amyloidosis with cardiomyopathy","authors":"Gregory B. Lim","doi":"10.1038/s41569-024-01086-y","DOIUrl":"10.1038/s41569-024-01086-y","url":null,"abstract":"Data from the HELIOS-B trial show that RNA interference with vutrisiran reduces the risk of death and recurrent cardiovascular events in patients with transthyretin amyloidosis with cardiomyopathy.","PeriodicalId":18976,"journal":{"name":"Nature Reviews Cardiology","volume":"21 11","pages":"740-740"},"PeriodicalIF":41.7,"publicationDate":"2024-09-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142245400","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Reproductive options and genetic testing for patients with an inherited cardiac disease 遗传性心脏病患者的生殖选择和基因检测
IF 49.6 1区 医学
Nature Reviews Cardiology Pub Date : 2024-09-17 DOI: 10.1038/s41569-024-01073-3
Job A. J. Verdonschot, Aimee D. C. Paulussen, Neal K. Lakdawala, Christine E. M. de Die-Smulders, James S. Ware, Jodie Ingles
{"title":"Reproductive options and genetic testing for patients with an inherited cardiac disease","authors":"Job A. J. Verdonschot, Aimee D. C. Paulussen, Neal K. Lakdawala, Christine E. M. de Die-Smulders, James S. Ware, Jodie Ingles","doi":"10.1038/s41569-024-01073-3","DOIUrl":"https://doi.org/10.1038/s41569-024-01073-3","url":null,"abstract":"<p>In the past decade, genetic testing for cardiac disease has become part of routine clinical care. A genetic diagnosis provides the possibility to clarify risk for relatives. For family planning, a genetic diagnosis provides reproductive options, including prenatal diagnosis and preimplantation genetic testing, that can prevent an affected parent from having a child with the genetic predisposition. Owing to the complex genetic architecture of cardiac diseases, characterized by incomplete disease penetrance and the interplay between monogenic and polygenic variants, the risk reduction that can be achieved using reproductive genetic testing varies among individuals. Globally, disparities, including regulatory and financial barriers, in access to reproductive genetic tests exist. Although reproductive options are gaining a prominent position in the management of patients with inherited cardiac diseases, specific policies and guidance are lacking. Guidelines recommend that prenatal diagnosis and preimplantation genetic testing are options that should be discussed with families. Health-care professionals should, therefore, be aware of the possibilities and feel confident to discuss the benefits and challenges. In this Review, we provide an overview of the reproductive options in the context of inherited cardiac diseases, covering the genetic, technical, psychosocial and equity considerations, to prepare health-care professionals for discussions with their patients.</p>","PeriodicalId":18976,"journal":{"name":"Nature Reviews Cardiology","volume":"53 1","pages":""},"PeriodicalIF":49.6,"publicationDate":"2024-09-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142235050","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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