Nature Reviews Cardiology最新文献_第2页

Environmental sustainability in cardiovascular practice: current challenges and future directions 心血管实践中的环境可持续性：当前挑战与未来方向

IF 49.6 1区医学

Nature Reviews Cardiology Pub Date : 2024-10-25 DOI: 10.1038/s41569-024-01077-z

Sanjay Rajagopalan, Scott McAlister, Jason Jay, Richard D. Pham, Robert D. Brook, Khurram Nasir, Mark. J. Nieuwenhuijsen, Philip Landrigan, Allegra Wiesler, Christina Vernon Sanborn, Justin R. Carron, Kara Hammond Brooks, Aruni Bhatnagar, Sadeer Al-Kindi

{"title":"Environmental sustainability in cardiovascular practice: current challenges and future directions","authors":"Sanjay Rajagopalan, Scott McAlister, Jason Jay, Richard D. Pham, Robert D. Brook, Khurram Nasir, Mark. J. Nieuwenhuijsen, Philip Landrigan, Allegra Wiesler, Christina Vernon Sanborn, Justin R. Carron, Kara Hammond Brooks, Aruni Bhatnagar, Sadeer Al-Kindi","doi":"10.1038/s41569-024-01077-z","DOIUrl":"https://doi.org/10.1038/s41569-024-01077-z","url":null,"abstract":"Cardiovascular disease is the leading cause of morbidity and mortality worldwide, with a substantial amount of health-care resources targeted towards its diagnosis and management. Environmental sustainability in cardiovascular care can have an important role in reducing greenhouse gas emissions and pollution and could be beneficial for improving health metrics and societal well-being and minimizing the cost of health care. In this Review, we discuss the motivations and frameworks for sustainable cardiovascular care with an emphasis on the reduction of the climate-related and environmental effects of cardiovascular care. We also provide an overview of greenhouse gas emissions related to the provision of health care, including their measurement and quantification, carbon accounting, carbon disclosures and climate effects. The principles of life-cycle assessment, waste prevention and circular economics in health care are discussed, and the emissions associated with various sectors of cardiovascular care as well as the rationale for prevention as a powerful approach to reduce these emissions are presented. Finally, we highlight the challenges in environmental sustainability and future directions as applicable to cardiovascular practice.","PeriodicalId":18976,"journal":{"name":"Nature Reviews Cardiology","volume":"235 1","pages":""},"PeriodicalIF":49.6,"publicationDate":"2024-10-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142489618","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

OpenEP and EP Workbench for electrophysiology data analysis 用于电生理学数据分析的 OpenEP 和 EP 工作台

IF 49.6 1区医学

Nature Reviews Cardiology Pub Date : 2024-10-23 DOI: 10.1038/s41569-024-01092-0

Neil Bodagh, Steven E. Williams

引用次数: 0

Translation of pathophysiological mechanisms of atrial fibrosis into new diagnostic and therapeutic approaches 将心房纤维化的病理生理机制转化为新的诊断和治疗方法

IF 49.6 1区医学

Nature Reviews Cardiology Pub Date : 2024-10-23 DOI: 10.1038/s41569-024-01088-w

Ulrich Schotten, Andreas Goette, Sander Verheule

{"title":"Translation of pathophysiological mechanisms of atrial fibrosis into new diagnostic and therapeutic approaches","authors":"Ulrich Schotten, Andreas Goette, Sander Verheule","doi":"10.1038/s41569-024-01088-w","DOIUrl":"https://doi.org/10.1038/s41569-024-01088-w","url":null,"abstract":"Atrial fibrosis is one of the main manifestations of atrial cardiomyopathy, an array of electrical, mechanical and structural alterations associated with atrial fibrillation (AF), stroke and heart failure. Atrial fibrosis can be both a cause and a consequence of AF and, once present, it accelerates the progression of AF. The pathophysiological mechanisms leading to atrial fibrosis are diverse and include stretch-induced activation of fibroblasts, systemic inflammatory processes, activation of coagulation factors and fibrofatty infiltrations. Importantly, atrial fibrosis can occur in different forms, such as reactive and replacement fibrosis. The diversity of atrial fibrosis mechanisms and patterns depends on sex, age and comorbidity profile, hampering the development of therapeutic strategies. In addition, the presence and severity of comorbidities often change over time, potentially causing temporal changes in the mechanisms underlying atrial fibrosis development. This Review summarizes the latest knowledge on the molecular and cellular mechanisms of atrial fibrosis, its association with comorbidities and the sex-related differences. We describe how the various patterns of atrial fibrosis translate into electrophysiological mechanisms that promote AF, and critically appraise the clinical applicability and limitations of diagnostic tools to quantify atrial fibrosis. Finally, we provide an overview of the newest therapeutic interventions under development and discuss relevant knowledge gaps related to the association between clinical manifestations and pathological mechanisms of atrial fibrosis and to the translation of this knowledge to a clinical setting.","PeriodicalId":18976,"journal":{"name":"Nature Reviews Cardiology","volume":"13 1","pages":""},"PeriodicalIF":49.6,"publicationDate":"2024-10-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142487832","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Lower your cholesterol early, and stick with it! 尽早降低胆固醇，并坚持下去！

IF 49.6 1区医学

Nature Reviews Cardiology Pub Date : 2024-10-18 DOI: 10.1038/s41569-024-01095-x

Filip K. Swirski, Christoph J. Binder

引用次数: 0

Clinical and subclinical acute brain injury caused by invasive cardiovascular procedures 侵入性心血管手术造成的临床和亚临床急性脑损伤

IF 49.6 1区医学

Nature Reviews Cardiology Pub Date : 2024-10-11 DOI: 10.1038/s41569-024-01076-0

Radosław Lenarczyk, Marco Proietti, Jan F. Scheitz, Dipen Shah, Eberhard Siebert, Diana A. Gorog, Jacek Kowalczyk, Nikolaos Bonaros, George Ntaios, Wolfram Doehner, Nicolas M. Van Mieghem, Sandor Nardai, Jan Kovac, Roland Fiszer, Roberto Lorusso, Eliano Navarese, Sergio Castrejón, Andrea Rubboli, José Miguel Rivera-Caravaca, Alaide Chieffo, Gregory Y. H. Lip

{"title":"Clinical and subclinical acute brain injury caused by invasive cardiovascular procedures","authors":"Radosław Lenarczyk, Marco Proietti, Jan F. Scheitz, Dipen Shah, Eberhard Siebert, Diana A. Gorog, Jacek Kowalczyk, Nikolaos Bonaros, George Ntaios, Wolfram Doehner, Nicolas M. Van Mieghem, Sandor Nardai, Jan Kovac, Roland Fiszer, Roberto Lorusso, Eliano Navarese, Sergio Castrejón, Andrea Rubboli, José Miguel Rivera-Caravaca, Alaide Chieffo, Gregory Y. H. Lip","doi":"10.1038/s41569-024-01076-0","DOIUrl":"https://doi.org/10.1038/s41569-024-01076-0","url":null,"abstract":"Over the past 50 years, the number and invasiveness of percutaneous cardiovascular procedures globally have increased substantially. However, cardiovascular interventions are inherently associated with a risk of acute brain injury, both periprocedurally and postprocedurally, which impairs medical outcomes and increases health-care costs. Current international clinical guidelines generally do not cover the area of acute brain injury related to cardiovascular invasive procedures. In this international Consensus Statement, we compile the available knowledge (including data on prevalence, pathophysiology, risk factors, clinical presentation and management) to formulate consensus recommendations on the prevention, diagnosis and treatment of acute brain injury caused by cardiovascular interventions. We also identify knowledge gaps and possible future directions in clinical research into acute brain injury related to cardiovascular interventions.","PeriodicalId":18976,"journal":{"name":"Nature Reviews Cardiology","volume":"9 1","pages":""},"PeriodicalIF":49.6,"publicationDate":"2024-10-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142404905","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Pathophysiology of dilated cardiomyopathy: from mechanisms to precision medicine 扩张型心肌病的病理生理学：从机制到精准医学

IF 49.6 1区医学

Nature Reviews Cardiology Pub Date : 2024-10-11 DOI: 10.1038/s41569-024-01074-2

Marta Gigli, Davide Stolfo, Marco Merlo, Gianfranco Sinagra, Matthew R. G. Taylor, Luisa Mestroni

{"title":"Pathophysiology of dilated cardiomyopathy: from mechanisms to precision medicine","authors":"Marta Gigli, Davide Stolfo, Marco Merlo, Gianfranco Sinagra, Matthew R. G. Taylor, Luisa Mestroni","doi":"10.1038/s41569-024-01074-2","DOIUrl":"https://doi.org/10.1038/s41569-024-01074-2","url":null,"abstract":"Dilated cardiomyopathy (DCM) is a complex disease with multiple causes and various pathogenic mechanisms. Despite improvements in the prognosis of patients with DCM in the past decade, this condition remains a leading cause of heart failure and premature death. Conventional treatment for DCM is based on the foundational therapies for heart failure with reduced ejection fraction. However, increasingly, attention is being directed towards individualized treatments and precision medicine. The ability to confirm genetic causality is gradually being complemented by an increased understanding of genotype–phenotype correlations. Non-genetic factors also influence the onset of DCM, and growing evidence links genetic background with concomitant non-genetic triggers or precipitating factors, increasing the extreme complexity of the pathophysiology of DCM. This Review covers the spectrum of pathophysiological mechanisms in DCM, from monogenic causes to the coexistence of genetic abnormalities and triggering environmental factors (the ‘two-hit’ hypothesis). The roles of common genetic variants in the general population and of gene modifiers in disease onset and progression are also discussed. Finally, areas for future research are highlighted, particularly novel therapies, such as small molecules, RNA and gene therapy, and measures for the prevention of arrhythmic death.","PeriodicalId":18976,"journal":{"name":"Nature Reviews Cardiology","volume":"228 1","pages":""},"PeriodicalIF":49.6,"publicationDate":"2024-10-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142404906","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

β-blockers after MI: does ABYSS confirm REDUCEd use after all? 心肌梗死后使用 β 受体阻滞剂：ABYSS 是否证实了 REDUCEd 的使用？

IF 49.6 1区医学

Nature Reviews Cardiology Pub Date : 2024-10-09 DOI: 10.1038/s41569-024-01093-z

Robin Hofmann, Stefan James

引用次数: 0

The burden of atrial fibrillation in the Asia–Pacific region 亚太地区心房颤动的负担

IF 41.7 1区医学

Nature Reviews Cardiology Pub Date : 2024-09-25 DOI: 10.1038/s41569-024-01091-1

Christopher X. Wong, Hung Fat Tse, Eue-Kuen Choi, Tze-Fan Chao, Koichi Inoue, Katrina Poppe, Eugene Tan, Yoga Yuniadi, Erdie Fadreguilan, Sofian Johar, Ngai Yin Chan, Narayan Namboodiri, S. Mokaddas Hossain, Huang He, Thoranis Chantrarat, Abdul Raqib Bin Abd Ghani, Narantuya Davaakhuu, Nwe Nwe, Ghazala Irfan, Minh That Ton, Rohan Gunawardena, Prashanthan Sanders

引用次数: 0

Soil and water pollution and cardiovascular disease 土壤和水污染与心血管疾病

IF 49.6 1区医学

Nature Reviews Cardiology Pub Date : 2024-09-25 DOI: 10.1038/s41569-024-01068-0

Thomas Münzel, Omar Hahad, Jos Lelieveld, Michael Aschner, Mark J. Nieuwenhuijsen, Philip J. Landrigan, Andreas Daiber

{"title":"Soil and water pollution and cardiovascular disease","authors":"Thomas Münzel, Omar Hahad, Jos Lelieveld, Michael Aschner, Mark J. Nieuwenhuijsen, Philip J. Landrigan, Andreas Daiber","doi":"10.1038/s41569-024-01068-0","DOIUrl":"https://doi.org/10.1038/s41569-024-01068-0","url":null,"abstract":"Healthy, uncontaminated soils and clean water support all life on Earth and are essential for human health. Chemical pollution of soil, water, air and food is a major environmental threat, leading to an estimated 9 million premature deaths worldwide. The Global Burden of Disease study estimated that pollution was responsible for 5.5 million deaths related to cardiovascular disease (CVD) in 2019. Robust evidence has linked multiple pollutants, including heavy metals, pesticides, dioxins and toxic synthetic chemicals, with increased risk of CVD, and some reports suggest an association between microplastic and nanoplastic particles and CVD. Pollutants in soil diminish its capacity to produce food, leading to crop impurities, malnutrition and disease, and they can seep into rivers, worsening water pollution. Deforestation, wildfires and climate change exacerbate pollution by triggering soil erosion and releasing sequestered pollutants into the air and water. Despite their varied chemical makeup, pollutants induce CVD through common pathophysiological mechanisms involving oxidative stress and inflammation. In this Review, we provide an overview of the relationship between soil and water pollution and human health and pathology, and discuss the prevalence of soil and water pollutants and how they contribute to adverse health effects, focusing on CVD.","PeriodicalId":18976,"journal":{"name":"Nature Reviews Cardiology","volume":"35 1","pages":""},"PeriodicalIF":49.6,"publicationDate":"2024-09-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142314070","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Turning back time: the promise of cardiac regeneration 时光倒流：心脏再生的希望

IF 41.7 1区医学

Nature Reviews Cardiology Pub Date : 2024-09-24 DOI: 10.1038/s41569-024-01085-z

Elsa Lawrence, Catherine H. Wilson

引用次数: 0