Nature Reviews Cardiology最新文献_第2页

Cardiodermatology: the heart of the connection between the skin and cardiovascular disease 心脏皮肤病学：皮肤与心血管疾病之间的核心联系

IF 49.6 1区医学

Nature Reviews Cardiology Pub Date : 2024-11-13 DOI: 10.1038/s41569-024-01097-9

Joel M. Gelfand, William B. Song, Sinéad M. Langan, Michael S. Garshick

{"title":"Cardiodermatology: the heart of the connection between the skin and cardiovascular disease","authors":"Joel M. Gelfand, William B. Song, Sinéad M. Langan, Michael S. Garshick","doi":"10.1038/s41569-024-01097-9","DOIUrl":"https://doi.org/10.1038/s41569-024-01097-9","url":null,"abstract":"The skin and cardiovascular systems are connected in unique and meaningful ways, and many diseases conventionally considered as being limited to one organ system are more closely related than previously believed. Major cardiovascular diseases and phenomena such as infective endocarditis, congestive heart failure, Kawasaki disease and thromboembolism are associated with specific skin findings, and advances in genetics, immunology and clinical epidemiology show that inflammatory dermatological diseases, such as psoriasis, have serious cardiovascular and cardiometabolic consequences. Additionally, commonly used cardiovascular therapies, such as antihypertensive medications, are associated with important cutaneous adverse effects, including photosensitivity, photocarcinogenesis and eczematous skin reactions. Moreover, systemic dermatological therapies, including retinoids, Janus kinase inhibitors and biologics, can alter the risk of cardiovascular and cardiometabolic diseases. In this Review on cardiodermatology, we provide interdisciplinary insights from dermatology and cardiology that will be of practical use to both cardiologists and generalists who manage cardiovascular and cardiometabolic diseases in patients with dermatological findings or histories. We discuss specific skin findings associated with cardiovascular diseases to aid in diagnosis; important cutaneous adverse effects of common cardiovascular therapies, for the purpose of treatment monitoring; and the effect of dermatological diseases and dermatological treatment on cardiovascular risk.","PeriodicalId":18976,"journal":{"name":"Nature Reviews Cardiology","volume":"12 1","pages":""},"PeriodicalIF":49.6,"publicationDate":"2024-11-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142609970","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Our revered and mysterious heart 我们崇敬而神秘的心

IF 41.7 1区医学

Nature Reviews Cardiology Pub Date : 2024-11-06 DOI: 10.1038/s41569-024-01096-w

Philip Kilner

引用次数: 0

Nanomedicine-based strategies for the treatment of vein graft disease 基于纳米药物的静脉移植疾病治疗策略

IF 49.6 1区医学

Nature Reviews Cardiology Pub Date : 2024-11-05 DOI: 10.1038/s41569-024-01094-y

Zhuoming Zhou, Wei Chen, Yihai Cao, Reza Abdi, Wei Tao

{"title":"Nanomedicine-based strategies for the treatment of vein graft disease","authors":"Zhuoming Zhou, Wei Chen, Yihai Cao, Reza Abdi, Wei Tao","doi":"10.1038/s41569-024-01094-y","DOIUrl":"https://doi.org/10.1038/s41569-024-01094-y","url":null,"abstract":"Autologous saphenous veins are the most frequently used conduits for coronary and peripheral artery bypass grafting. However, vein graft failure rates of 40–50% within 10 years of the implantation lead to poor long-term outcomes after bypass surgery. Currently, only a few therapeutic approaches for vein graft disease have been successfully translated into clinical practice. Building on the past two decades of advanced understanding of vein graft biology and the pathophysiological mechanisms underlying vein graft disease, nanomedicine-based strategies offer promising opportunities to address this important unmet clinical need. In this Review, we provide deep insight into the latest developments in the rational design and applications of nanoparticles that have the potential to target specific cells during various pathophysiological stages of vein graft disease, including early endothelial dysfunction, intermediate intimal hyperplasia and late-stage accelerated atherosclerosis. Additionally, we underscore the convergence of nanofabricated biomaterials, with a particular focus on hydrogels, external graft support devices and cell-based therapies, alongside bypass surgery to improve local delivery efficiency and therapeutic efficacy. Finally, we provide a specific discussion on the considerations, challenges and novel perspectives for the future clinical translation of nanomedicine for the treatment of vein graft disease.","PeriodicalId":18976,"journal":{"name":"Nature Reviews Cardiology","volume":"67 1","pages":""},"PeriodicalIF":49.6,"publicationDate":"2024-11-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142580063","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Environmental sustainability in cardiovascular practice: current challenges and future directions 心血管实践中的环境可持续性：当前挑战与未来方向

IF 49.6 1区医学

Nature Reviews Cardiology Pub Date : 2024-10-25 DOI: 10.1038/s41569-024-01077-z

Sanjay Rajagopalan, Scott McAlister, Jason Jay, Richard D. Pham, Robert D. Brook, Khurram Nasir, Mark. J. Nieuwenhuijsen, Philip Landrigan, Allegra Wiesler, Christina Vernon Sanborn, Justin R. Carron, Kara Hammond Brooks, Aruni Bhatnagar, Sadeer Al-Kindi

{"title":"Environmental sustainability in cardiovascular practice: current challenges and future directions","authors":"Sanjay Rajagopalan, Scott McAlister, Jason Jay, Richard D. Pham, Robert D. Brook, Khurram Nasir, Mark. J. Nieuwenhuijsen, Philip Landrigan, Allegra Wiesler, Christina Vernon Sanborn, Justin R. Carron, Kara Hammond Brooks, Aruni Bhatnagar, Sadeer Al-Kindi","doi":"10.1038/s41569-024-01077-z","DOIUrl":"https://doi.org/10.1038/s41569-024-01077-z","url":null,"abstract":"Cardiovascular disease is the leading cause of morbidity and mortality worldwide, with a substantial amount of health-care resources targeted towards its diagnosis and management. Environmental sustainability in cardiovascular care can have an important role in reducing greenhouse gas emissions and pollution and could be beneficial for improving health metrics and societal well-being and minimizing the cost of health care. In this Review, we discuss the motivations and frameworks for sustainable cardiovascular care with an emphasis on the reduction of the climate-related and environmental effects of cardiovascular care. We also provide an overview of greenhouse gas emissions related to the provision of health care, including their measurement and quantification, carbon accounting, carbon disclosures and climate effects. The principles of life-cycle assessment, waste prevention and circular economics in health care are discussed, and the emissions associated with various sectors of cardiovascular care as well as the rationale for prevention as a powerful approach to reduce these emissions are presented. Finally, we highlight the challenges in environmental sustainability and future directions as applicable to cardiovascular practice.","PeriodicalId":18976,"journal":{"name":"Nature Reviews Cardiology","volume":"235 1","pages":""},"PeriodicalIF":49.6,"publicationDate":"2024-10-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142489618","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

OpenEP and EP Workbench for electrophysiology data analysis 用于电生理学数据分析的 OpenEP 和 EP 工作台

IF 41.7 1区医学

Nature Reviews Cardiology Pub Date : 2024-10-23 DOI: 10.1038/s41569-024-01092-0

Neil Bodagh, Steven E. Williams

引用次数: 0

Translation of pathophysiological mechanisms of atrial fibrosis into new diagnostic and therapeutic approaches 将心房纤维化的病理生理机制转化为新的诊断和治疗方法

IF 49.6 1区医学

Nature Reviews Cardiology Pub Date : 2024-10-23 DOI: 10.1038/s41569-024-01088-w

Ulrich Schotten, Andreas Goette, Sander Verheule

{"title":"Translation of pathophysiological mechanisms of atrial fibrosis into new diagnostic and therapeutic approaches","authors":"Ulrich Schotten, Andreas Goette, Sander Verheule","doi":"10.1038/s41569-024-01088-w","DOIUrl":"https://doi.org/10.1038/s41569-024-01088-w","url":null,"abstract":"Atrial fibrosis is one of the main manifestations of atrial cardiomyopathy, an array of electrical, mechanical and structural alterations associated with atrial fibrillation (AF), stroke and heart failure. Atrial fibrosis can be both a cause and a consequence of AF and, once present, it accelerates the progression of AF. The pathophysiological mechanisms leading to atrial fibrosis are diverse and include stretch-induced activation of fibroblasts, systemic inflammatory processes, activation of coagulation factors and fibrofatty infiltrations. Importantly, atrial fibrosis can occur in different forms, such as reactive and replacement fibrosis. The diversity of atrial fibrosis mechanisms and patterns depends on sex, age and comorbidity profile, hampering the development of therapeutic strategies. In addition, the presence and severity of comorbidities often change over time, potentially causing temporal changes in the mechanisms underlying atrial fibrosis development. This Review summarizes the latest knowledge on the molecular and cellular mechanisms of atrial fibrosis, its association with comorbidities and the sex-related differences. We describe how the various patterns of atrial fibrosis translate into electrophysiological mechanisms that promote AF, and critically appraise the clinical applicability and limitations of diagnostic tools to quantify atrial fibrosis. Finally, we provide an overview of the newest therapeutic interventions under development and discuss relevant knowledge gaps related to the association between clinical manifestations and pathological mechanisms of atrial fibrosis and to the translation of this knowledge to a clinical setting.","PeriodicalId":18976,"journal":{"name":"Nature Reviews Cardiology","volume":"13 1","pages":""},"PeriodicalIF":49.6,"publicationDate":"2024-10-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142487832","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Lower your cholesterol early, and stick with it! 尽早降低胆固醇，并坚持下去！

IF 49.6 1区医学

Nature Reviews Cardiology Pub Date : 2024-10-18 DOI: 10.1038/s41569-024-01095-x

Filip K. Swirski, Christoph J. Binder

引用次数: 0

Clinical and subclinical acute brain injury caused by invasive cardiovascular procedures 侵入性心血管手术造成的临床和亚临床急性脑损伤

IF 49.6 1区医学

Nature Reviews Cardiology Pub Date : 2024-10-11 DOI: 10.1038/s41569-024-01076-0

Radosław Lenarczyk, Marco Proietti, Jan F. Scheitz, Dipen Shah, Eberhard Siebert, Diana A. Gorog, Jacek Kowalczyk, Nikolaos Bonaros, George Ntaios, Wolfram Doehner, Nicolas M. Van Mieghem, Sandor Nardai, Jan Kovac, Roland Fiszer, Roberto Lorusso, Eliano Navarese, Sergio Castrejón, Andrea Rubboli, José Miguel Rivera-Caravaca, Alaide Chieffo, Gregory Y. H. Lip

{"title":"Clinical and subclinical acute brain injury caused by invasive cardiovascular procedures","authors":"Radosław Lenarczyk, Marco Proietti, Jan F. Scheitz, Dipen Shah, Eberhard Siebert, Diana A. Gorog, Jacek Kowalczyk, Nikolaos Bonaros, George Ntaios, Wolfram Doehner, Nicolas M. Van Mieghem, Sandor Nardai, Jan Kovac, Roland Fiszer, Roberto Lorusso, Eliano Navarese, Sergio Castrejón, Andrea Rubboli, José Miguel Rivera-Caravaca, Alaide Chieffo, Gregory Y. H. Lip","doi":"10.1038/s41569-024-01076-0","DOIUrl":"https://doi.org/10.1038/s41569-024-01076-0","url":null,"abstract":"Over the past 50 years, the number and invasiveness of percutaneous cardiovascular procedures globally have increased substantially. However, cardiovascular interventions are inherently associated with a risk of acute brain injury, both periprocedurally and postprocedurally, which impairs medical outcomes and increases health-care costs. Current international clinical guidelines generally do not cover the area of acute brain injury related to cardiovascular invasive procedures. In this international Consensus Statement, we compile the available knowledge (including data on prevalence, pathophysiology, risk factors, clinical presentation and management) to formulate consensus recommendations on the prevention, diagnosis and treatment of acute brain injury caused by cardiovascular interventions. We also identify knowledge gaps and possible future directions in clinical research into acute brain injury related to cardiovascular interventions.","PeriodicalId":18976,"journal":{"name":"Nature Reviews Cardiology","volume":"9 1","pages":""},"PeriodicalIF":49.6,"publicationDate":"2024-10-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142404905","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Pathophysiology of dilated cardiomyopathy: from mechanisms to precision medicine 扩张型心肌病的病理生理学：从机制到精准医学

IF 49.6 1区医学

Nature Reviews Cardiology Pub Date : 2024-10-11 DOI: 10.1038/s41569-024-01074-2

Marta Gigli, Davide Stolfo, Marco Merlo, Gianfranco Sinagra, Matthew R. G. Taylor, Luisa Mestroni

{"title":"Pathophysiology of dilated cardiomyopathy: from mechanisms to precision medicine","authors":"Marta Gigli, Davide Stolfo, Marco Merlo, Gianfranco Sinagra, Matthew R. G. Taylor, Luisa Mestroni","doi":"10.1038/s41569-024-01074-2","DOIUrl":"https://doi.org/10.1038/s41569-024-01074-2","url":null,"abstract":"Dilated cardiomyopathy (DCM) is a complex disease with multiple causes and various pathogenic mechanisms. Despite improvements in the prognosis of patients with DCM in the past decade, this condition remains a leading cause of heart failure and premature death. Conventional treatment for DCM is based on the foundational therapies for heart failure with reduced ejection fraction. However, increasingly, attention is being directed towards individualized treatments and precision medicine. The ability to confirm genetic causality is gradually being complemented by an increased understanding of genotype–phenotype correlations. Non-genetic factors also influence the onset of DCM, and growing evidence links genetic background with concomitant non-genetic triggers or precipitating factors, increasing the extreme complexity of the pathophysiology of DCM. This Review covers the spectrum of pathophysiological mechanisms in DCM, from monogenic causes to the coexistence of genetic abnormalities and triggering environmental factors (the ‘two-hit’ hypothesis). The roles of common genetic variants in the general population and of gene modifiers in disease onset and progression are also discussed. Finally, areas for future research are highlighted, particularly novel therapies, such as small molecules, RNA and gene therapy, and measures for the prevention of arrhythmic death.","PeriodicalId":18976,"journal":{"name":"Nature Reviews Cardiology","volume":"228 1","pages":""},"PeriodicalIF":49.6,"publicationDate":"2024-10-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142404906","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

β-blockers after MI: does ABYSS confirm REDUCEd use after all? 心肌梗死后使用 β 受体阻滞剂：ABYSS 是否证实了 REDUCEd 的使用？

IF 41.7 1区医学

Nature Reviews Cardiology Pub Date : 2024-10-09 DOI: 10.1038/s41569-024-01093-z

Robin Hofmann, Stefan James

引用次数: 0