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Tunnelling nanotube-like structures facilitate cell–cell communication during heart development
IF 49.6 1区 医学
Nature Reviews Cardiology Pub Date : 2025-04-02 DOI: 10.1038/s41569-025-01151-0
Karina Huynh
{"title":"Tunnelling nanotube-like structures facilitate cell–cell communication during heart development","authors":"Karina Huynh","doi":"10.1038/s41569-025-01151-0","DOIUrl":"https://doi.org/10.1038/s41569-025-01151-0","url":null,"abstract":"A new study reports the presence of tunnelling nanotube-like structures in mouse embryonic hearts that have a crucial role in facilitating long-distance cell–cell communication during early heart morphogenesis.","PeriodicalId":18976,"journal":{"name":"Nature Reviews Cardiology","volume":"55 1","pages":""},"PeriodicalIF":49.6,"publicationDate":"2025-04-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143758152","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Clonal haematopoiesis in cardiovascular disease: prognostic role and novel therapeutic target
IF 49.6 1区 医学
Nature Reviews Cardiology Pub Date : 2025-04-02 DOI: 10.1038/s41569-025-01148-9
Art Schuermans, Michael C. Honigberg
{"title":"Clonal haematopoiesis in cardiovascular disease: prognostic role and novel therapeutic target","authors":"Art Schuermans, Michael C. Honigberg","doi":"10.1038/s41569-025-01148-9","DOIUrl":"https://doi.org/10.1038/s41569-025-01148-9","url":null,"abstract":"<p>Clonal haematopoiesis is the clonal expansion of blood stem cells with acquired mutations. Clonal haematopoiesis of indeterminate potential (CHIP), traditionally defined as clonal haematopoiesis driven by a pre-leukaemic mutation in at least 2% of sequenced alleles, affects 10–20% of individuals aged &gt;70 years. Although CHIP is considered a precursor condition for haematological malignancies, population-based data suggest that the majority of CHIP-associated mortality is attributable to non-malignant conditions, such as cardiovascular disease. Observational human studies have shown that CHIP is a strong and independent predictor of the onset and progression of atherosclerotic cardiovascular disease, heart failure and arrhythmia. In addition, findings from animal experiments suggest that CHIP is causally involved in these diseases and might be a risk factor that can be targeted with therapeutics. As our understanding of the cardiovascular implications of CHIP and other types of clonal haematopoiesis rapidly expands, it has become increasingly clear that clonal haematopoiesis subtypes have substantial heterogeneity with respect to magnitude of effect and underlying mechanisms for different cardiovascular diseases. In this Review, we discuss clonal haematopoiesis as a prognostic factor for numerous cardiovascular diseases, highlight its potential as a therapeutic target and propose a potential role for CHIP in cardiovascular precision medicine.</p>","PeriodicalId":18976,"journal":{"name":"Nature Reviews Cardiology","volume":"183 1","pages":""},"PeriodicalIF":49.6,"publicationDate":"2025-04-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143766570","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Factor XI inhibitors for the prevention and treatment of venous and arterial thromboembolism
IF 49.6 1区 医学
Nature Reviews Cardiology Pub Date : 2025-03-31 DOI: 10.1038/s41569-025-01144-z
Davide Capodanno, John H. Alexander, M. Cecilia Bahit, John W. Eikelboom, C. Michael Gibson, Shaun G. Goodman, Vijay Kunadian, Gregory Y. H. Lip, Renato D. Lopes, Roxana Mehran, Shamir R. Mehta, Manesh R. Patel, Jonathan P. Piccini, Sunil V. Rao, Christian T. Ruff, P. Gabriel Steg, Jeffrey I. Weitz, Dominick J. Angiolillo
{"title":"Factor XI inhibitors for the prevention and treatment of venous and arterial thromboembolism","authors":"Davide Capodanno, John H. Alexander, M. Cecilia Bahit, John W. Eikelboom, C. Michael Gibson, Shaun G. Goodman, Vijay Kunadian, Gregory Y. H. Lip, Renato D. Lopes, Roxana Mehran, Shamir R. Mehta, Manesh R. Patel, Jonathan P. Piccini, Sunil V. Rao, Christian T. Ruff, P. Gabriel Steg, Jeffrey I. Weitz, Dominick J. Angiolillo","doi":"10.1038/s41569-025-01144-z","DOIUrl":"https://doi.org/10.1038/s41569-025-01144-z","url":null,"abstract":"<p>Therapeutic anticoagulation is essential to prevent and treat venous and arterial thromboembolism. The available agents target coagulation factors involved in thrombus formation but are associated with an increased risk of bleeding. Factor XI plays a minor role in haemostasis but contributes substantially to thrombus expansion, making it an attractive target to mitigate bleeding while maintaining antithrombotic efficacy. Various novel inhibitors, including antisense oligonucleotides, monoclonal antibodies and small molecules, have been developed. Phase II trials in orthopaedic surgery showed dose-dependent reductions in venous thromboembolism without significantly increasing bleeding compared with enoxaparin. In the first phase III trial of a small-molecule inhibitor of activated factor XI in patients with atrial fibrillation, asundexian was associated with a reduction in bleeding but also a higher risk of stroke, compared with apixaban. Factor XI inhibitors appear safe and hold promise for secondary prevention in myocardial infarction and ischaemic stroke, with ongoing phase III trials assessing their broader efficacy and safety. This Review discusses the rationale, pharmacology, evidence and future directions of factor XI inhibitors across various clinical settings.</p>","PeriodicalId":18976,"journal":{"name":"Nature Reviews Cardiology","volume":"5 1","pages":""},"PeriodicalIF":49.6,"publicationDate":"2025-03-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143744689","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Scientific journey from PSCK9 discovery in familial hypercholesterolaemia
IF 49.6 1区 医学
Nature Reviews Cardiology Pub Date : 2025-03-28 DOI: 10.1038/s41569-025-01147-w
Marianne Abifadel
{"title":"Scientific journey from PSCK9 discovery in familial hypercholesterolaemia","authors":"Marianne Abifadel","doi":"10.1038/s41569-025-01147-w","DOIUrl":"https://doi.org/10.1038/s41569-025-01147-w","url":null,"abstract":"Countries globally face major challenges in the early diagnosis and treatment of hypercholesterolaemia and cardiovascular disease, with numerous health inequities by geography and income. Perseverance, hard work, integrity and commitment can transform aspiration into reality. My PCSK9 story, from the discovery of its implication in familial hypercholesterolemia to the development of life-saving drugs, is a real example.","PeriodicalId":18976,"journal":{"name":"Nature Reviews Cardiology","volume":"36 1","pages":""},"PeriodicalIF":49.6,"publicationDate":"2025-03-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143723165","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Ceramides aggravate atherosclerosis via G protein-coupled receptor signalling
IF 49.6 1区 医学
Nature Reviews Cardiology Pub Date : 2025-03-26 DOI: 10.1038/s41569-025-01149-8
Irene Fernández-Ruiz
{"title":"Ceramides aggravate atherosclerosis via G protein-coupled receptor signalling","authors":"Irene Fernández-Ruiz","doi":"10.1038/s41569-025-01149-8","DOIUrl":"https://doi.org/10.1038/s41569-025-01149-8","url":null,"abstract":"A study published in Nature has identified two transmembrane G protein-coupled receptors that mediate extracellular-to-intracellular ceramide signalling and shows that blocking these receptors alleviates the atherosclerosis that is induced by a high-fat diet or aggravated by chronic kidney disease in mice.","PeriodicalId":18976,"journal":{"name":"Nature Reviews Cardiology","volume":"20 1","pages":""},"PeriodicalIF":49.6,"publicationDate":"2025-03-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143712814","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Mitochondrial quality control in cardiomyocytes: safeguarding the heart against disease and ageing
IF 49.6 1区 医学
Nature Reviews Cardiology Pub Date : 2025-03-20 DOI: 10.1038/s41569-025-01142-1
Rishith Ravindran, Åsa B. Gustafsson
{"title":"Mitochondrial quality control in cardiomyocytes: safeguarding the heart against disease and ageing","authors":"Rishith Ravindran, Åsa B. Gustafsson","doi":"10.1038/s41569-025-01142-1","DOIUrl":"https://doi.org/10.1038/s41569-025-01142-1","url":null,"abstract":"<p>Mitochondria are multifunctional organelles that are important for many different cellular processes, including energy production and biosynthesis of fatty acids, haem and iron–sulfur clusters. Mitochondrial dysfunction leads to a disruption in these processes, the generation of excessive reactive oxygen species, and the activation of inflammatory and cell death pathways. The consequences of mitochondrial dysfunction are particularly harmful in energy-demanding organs such as the heart. Loss of terminally differentiated cardiomyocytes leads to cardiac remodelling and a reduced ability to sustain contraction. Therefore, cardiomyocytes rely on multilayered mitochondrial quality control mechanisms to maintain a healthy population of mitochondria. Mitochondrial chaperones protect against protein misfolding and aggregation, and resident proteases eliminate damaged proteins through proteolysis. Irreparably damaged mitochondria can also be degraded through mitochondrial autophagy (mitophagy) or ejected from cells inside vesicles. The accumulation of dysfunctional mitochondria in cardiomyocytes is a hallmark of ageing and cardiovascular disease. This accumulation is driven by impaired mitochondrial quality control mechanisms and contributes to the development of heart failure. Therefore, there is a strong interest in developing therapies that directly target mitochondrial quality control in cardiomyocytes. In this Review, we discuss the current knowledge of the mechanisms involved in regulating mitochondrial quality in cardiomyocytes, how these pathways are altered with age and in disease, and the therapeutic potential of targeting mitochondrial quality control pathways in cardiovascular disease.</p>","PeriodicalId":18976,"journal":{"name":"Nature Reviews Cardiology","volume":"70 1","pages":""},"PeriodicalIF":49.6,"publicationDate":"2025-03-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143661037","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Extracellular vesicles in cardiovascular homeostasis and disease: potential role in diagnosis and therapy
IF 49.6 1区 医学
Nature Reviews Cardiology Pub Date : 2025-03-05 DOI: 10.1038/s41569-025-01141-2
Junjie Xiao, Joost P. G. Sluijter
{"title":"Extracellular vesicles in cardiovascular homeostasis and disease: potential role in diagnosis and therapy","authors":"Junjie Xiao, Joost P. G. Sluijter","doi":"10.1038/s41569-025-01141-2","DOIUrl":"https://doi.org/10.1038/s41569-025-01141-2","url":null,"abstract":"<p>Communication between multicellular organs is essential to propagate signals and coordinate their function. Over the past decade, the role of extracellular vesicles in the molecular communication between cells in both physiological and pathological settings has received much attention. Extracellular vesicles can shuttle proteins, lipids and nucleic acids (such as RNA) between cells, thus inducing an array of functional changes in the recipient cells. In this Review, we describe the different extracellular vesicle subclasses and their heterogeneous nature, provide insights into extracellular vesicle-mediated signalling in the cardiovascular system, and highlight how extracellular vesicles can be used as diagnostic and prognostic biomarkers for a variety of pathological conditions. Finally, we also discuss the potential therapeutic applications of extracellular vesicles.</p>","PeriodicalId":18976,"journal":{"name":"Nature Reviews Cardiology","volume":"10 1","pages":""},"PeriodicalIF":49.6,"publicationDate":"2025-03-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143545940","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The brain–heart axis: integrative cooperation of neural, mechanical and biochemical pathways 脑-心轴：神经、机械和生化途径的综合合作
IF 49.6 1区 医学
Nature Reviews Cardiology Pub Date : 2025-03-03 DOI: 10.1038/s41569-025-01140-3
Gaetano Valenza, Zoran Matić, Vincenzo Catrambone
{"title":"The brain–heart axis: integrative cooperation of neural, mechanical and biochemical pathways","authors":"Gaetano Valenza, Zoran Matić, Vincenzo Catrambone","doi":"10.1038/s41569-025-01140-3","DOIUrl":"https://doi.org/10.1038/s41569-025-01140-3","url":null,"abstract":"<p>The neural and cardiovascular systems are pivotal in regulating human physiological, cognitive and emotional states, constantly interacting through anatomical and functional connections referred to as the brain–heart axis. When this axis is dysfunctional, neurological conditions can lead to cardiovascular disorders and, conversely, cardiovascular dysfunction can substantially affect brain health. However, the mechanisms and fundamental physiological components of the brain–heart axis remain largely unknown. In this Review, we elucidate these components and identify three primary pathways: neural, mechanical and biochemical. The neural pathway involves the interaction between the autonomic nervous system and the central autonomic network in the brain. The mechanical pathway involves mechanoreceptors, particularly those expressing mechanosensitive Piezo protein channels, which relay crucial information about blood pressure through peripheral and cerebrovascular connections. The biochemical pathway comprises many endogenous compounds that are important mediators of neural and cardiovascular function. This multisystem perspective calls for the development of integrative approaches, leading to new clinical specialties in neurocardiology.</p>","PeriodicalId":18976,"journal":{"name":"Nature Reviews Cardiology","volume":"37 1","pages":""},"PeriodicalIF":49.6,"publicationDate":"2025-03-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143532339","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Epigenetic editing in cardiovascular medicine: moving beyond the hype
IF 49.6 1区 医学
Nature Reviews Cardiology Pub Date : 2025-02-28 DOI: 10.1038/s41569-025-01143-0
Luca Chiapperino, Michelle Habets, Francesco Paneni
{"title":"Epigenetic editing in cardiovascular medicine: moving beyond the hype","authors":"Luca Chiapperino, Michelle Habets, Francesco Paneni","doi":"10.1038/s41569-025-01143-0","DOIUrl":"https://doi.org/10.1038/s41569-025-01143-0","url":null,"abstract":"Epigenetic editing holds great promise for the treatment of many diseases, including cardiovascular disease. However, realizing this potential requires more than developing robust technology and demands a steadfast focus on patient needs and inclusion, to ensure that access to epigenetic medicine will be equitable and will benefit diverse populations worldwide.","PeriodicalId":18976,"journal":{"name":"Nature Reviews Cardiology","volume":"27 1","pages":""},"PeriodicalIF":49.6,"publicationDate":"2025-02-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143517928","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Endomyocardial fibrosis: recent advances and future therapeutic targets
IF 49.6 1区 医学
Nature Reviews Cardiology Pub Date : 2025-02-26 DOI: 10.1038/s41569-025-01138-x
Ana O. Mocumbi, Viviane Tiemi Hotta, Gene Bukhman, Ntobeko Ntusi, Magdi H. Yacoub, Paulo Correia-de-Sá
{"title":"Endomyocardial fibrosis: recent advances and future therapeutic targets","authors":"Ana O. Mocumbi, Viviane Tiemi Hotta, Gene Bukhman, Ntobeko Ntusi, Magdi H. Yacoub, Paulo Correia-de-Sá","doi":"10.1038/s41569-025-01138-x","DOIUrl":"https://doi.org/10.1038/s41569-025-01138-x","url":null,"abstract":"<p>Endomyocardial fibrosis, first described &gt;75 years ago, is a cause of restrictive cardiomyopathy with an unclear aetiopathogenesis that is most commonly found in children and adolescents from tropical regions of Africa, Asia and South America. The epidemiological trends of this cardiomyopathy are difficult to ascertain. The characteristic hallmark of endomyocardial fibrosis is ventricular fibrosis that causes diastolic dysfunction and atrioventricular regurgitation. Although advances in medical treatment for heart failure and more tailored surgical techniques to treat the condition have increased survival, the outcomes in affected patients remain poor. A major focus of research is the identification of biomarkers of preclinical disease and new therapeutic targets. Collaborative multidisciplinary research and cross-learning from other fibrotic conditions should impart knowledge and help to improve the survival rates and the quality of life of patients with endomyocardial fibrosis.</p>","PeriodicalId":18976,"journal":{"name":"Nature Reviews Cardiology","volume":"35 1","pages":""},"PeriodicalIF":49.6,"publicationDate":"2025-02-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143495374","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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