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Ultrasound-facilitated fibrinolysis reduces bleeding in intermediate-risk pulmonary embolism. 超声促进的纤溶可减少中危肺栓塞患者的出血。
IF 49.6 1区 医学
Nature Reviews Cardiology Pub Date : 2026-04-13 DOI: 10.1038/s41569-026-01292-w
Gregory B Lim
{"title":"Ultrasound-facilitated fibrinolysis reduces bleeding in intermediate-risk pulmonary embolism.","authors":"Gregory B Lim","doi":"10.1038/s41569-026-01292-w","DOIUrl":"https://doi.org/10.1038/s41569-026-01292-w","url":null,"abstract":"","PeriodicalId":18976,"journal":{"name":"Nature Reviews Cardiology","volume":"23 1","pages":""},"PeriodicalIF":49.6,"publicationDate":"2026-04-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147666527","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Left atrial appendage closure non-inferior to NOACs in atrial fibrillation. 房颤左心耳闭合优于NOACs。
IF 49.6 1区 医学
Nature Reviews Cardiology Pub Date : 2026-04-10 DOI: 10.1038/s41569-026-01289-5
Irene Fernández-Ruiz
{"title":"Left atrial appendage closure non-inferior to NOACs in atrial fibrillation.","authors":"Irene Fernández-Ruiz","doi":"10.1038/s41569-026-01289-5","DOIUrl":"https://doi.org/10.1038/s41569-026-01289-5","url":null,"abstract":"","PeriodicalId":18976,"journal":{"name":"Nature Reviews Cardiology","volume":"32 1","pages":""},"PeriodicalIF":49.6,"publicationDate":"2026-04-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147648896","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Placebo-controlled evidence for symptomatic benefit of PCI for chronic total occlusion in stable angina. 稳定型心绞痛慢性全闭塞PCI治疗的症状性获益的安慰剂对照证据。
IF 49.6 1区 医学
Nature Reviews Cardiology Pub Date : 2026-04-10 DOI: 10.1038/s41569-026-01290-y
Irene Fernández-Ruiz
{"title":"Placebo-controlled evidence for symptomatic benefit of PCI for chronic total occlusion in stable angina.","authors":"Irene Fernández-Ruiz","doi":"10.1038/s41569-026-01290-y","DOIUrl":"https://doi.org/10.1038/s41569-026-01290-y","url":null,"abstract":"","PeriodicalId":18976,"journal":{"name":"Nature Reviews Cardiology","volume":"33 1","pages":""},"PeriodicalIF":49.6,"publicationDate":"2026-04-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147648999","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Extremes of temperature and cardiovascular mortality. 极端温度和心血管死亡率。
IF 49.6 1区 医学
Nature Reviews Cardiology Pub Date : 2026-04-10 DOI: 10.1038/s41569-026-01288-6
Nam Nguyen,Urvish Jain
{"title":"Extremes of temperature and cardiovascular mortality.","authors":"Nam Nguyen,Urvish Jain","doi":"10.1038/s41569-026-01288-6","DOIUrl":"https://doi.org/10.1038/s41569-026-01288-6","url":null,"abstract":"","PeriodicalId":18976,"journal":{"name":"Nature Reviews Cardiology","volume":"13 1","pages":""},"PeriodicalIF":49.6,"publicationDate":"2026-04-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147648897","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Neutrophil extracellular traps in immunothrombosis. 免疫血栓形成中的中性粒细胞胞外陷阱。
IF 44.2 1区 医学
Nature Reviews Cardiology Pub Date : 2026-04-07 DOI: 10.1038/s41569-026-01285-9
Tyler Artner
{"title":"Neutrophil extracellular traps in immunothrombosis.","authors":"Tyler Artner","doi":"10.1038/s41569-026-01285-9","DOIUrl":"https://doi.org/10.1038/s41569-026-01285-9","url":null,"abstract":"","PeriodicalId":18976,"journal":{"name":"Nature Reviews Cardiology","volume":" ","pages":""},"PeriodicalIF":44.2,"publicationDate":"2026-04-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147633792","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Reframing atherothrombosis through the inflammation hypothesis. 通过炎症假说重构动脉粥样硬化血栓形成。
IF 49.6 1区 医学
Nature Reviews Cardiology Pub Date : 2026-04-07 DOI: 10.1038/s41569-026-01284-w
Art Schuermans
{"title":"Reframing atherothrombosis through the inflammation hypothesis.","authors":"Art Schuermans","doi":"10.1038/s41569-026-01284-w","DOIUrl":"https://doi.org/10.1038/s41569-026-01284-w","url":null,"abstract":"","PeriodicalId":18976,"journal":{"name":"Nature Reviews Cardiology","volume":"35 1","pages":""},"PeriodicalIF":49.6,"publicationDate":"2026-04-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147630188","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Cardiovascular stent technologies for coronary and valvular heart disease: the potential of 3D printing for stent fabrication. 冠心病和瓣膜性心脏病的心血管支架技术：3D打印支架制造的潜力。
IF 49.6 1区 医学
Nature Reviews Cardiology Pub Date : 2026-03-27 DOI: 10.1038/s41569-026-01275-x
Arian Ehterami,Sarah E Motta,Melanie Generali,Fergal B Coulter,Henryk Dreger,Volkmar Falk,Simon P Hoerstrup,Maximilian Y Emmert
{"title":"Cardiovascular stent technologies for coronary and valvular heart disease: the potential of 3D printing for stent fabrication.","authors":"Arian Ehterami,Sarah E Motta,Melanie Generali,Fergal B Coulter,Henryk Dreger,Volkmar Falk,Simon P Hoerstrup,Maximilian Y Emmert","doi":"10.1038/s41569-026-01275-x","DOIUrl":"https://doi.org/10.1038/s41569-026-01275-x","url":null,"abstract":"Over the past two decades, stents have revolutionized the treatment of cardiovascular diseases, particularly coronary artery and valvular heart disease. In this Review, we evaluate the clinical challenges associated with these diseases, as well as the manufacturing strategies for both coronary and heart valve stents, with a focus on the emerging role of 3D printing. Specifically, we assess the advantages and limitations of clinically available metallic and polymeric stents for coronary artery disease and provide an overview of the metallic and biodegradable polymeric stents developed to treat valvular heart disease. Furthermore, we explore the capabilities of key 3D-printing methods for stent fabrication, highlighting their strengths and drawbacks, and discuss the regulatory considerations that govern the clinical translation of 3D printing-based coronary and valvular stents. Taken together, 3D-printing technologies offer new opportunities to customize geometry, control stent degradation and improve stent implantation approaches for patients with complex anatomies. By merging innovations in material science, manufacturing strategies and bioengineering, 3D-printing technology has a major role in the next generation of personalized and multifunctional cardiovascular stents.","PeriodicalId":18976,"journal":{"name":"Nature Reviews Cardiology","volume":"20 1","pages":""},"PeriodicalIF":49.6,"publicationDate":"2026-03-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147524510","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Vascular smooth muscle cell plasticity in atherosclerosis. 动脉粥样硬化中血管平滑肌细胞的可塑性。
IF 49.6 1区 医学
Nature Reviews Cardiology Pub Date : 2026-03-26 DOI: 10.1038/s41569-026-01283-x
Laura Alonso-Herranz
{"title":"Vascular smooth muscle cell plasticity in atherosclerosis.","authors":"Laura Alonso-Herranz","doi":"10.1038/s41569-026-01283-x","DOIUrl":"https://doi.org/10.1038/s41569-026-01283-x","url":null,"abstract":"","PeriodicalId":18976,"journal":{"name":"Nature Reviews Cardiology","volume":"103 1","pages":""},"PeriodicalIF":49.6,"publicationDate":"2026-03-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147518502","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Global epidemiology of myocarditis: disparities in age, sex and geography. 心肌炎的全球流行病学：年龄、性别和地理差异。
IF 49.6 1区 医学
Nature Reviews Cardiology Pub Date : 2026-03-26 DOI: 10.1038/s41569-026-01276-w
Karin Klingel,Carsten Tschöpe,Dong Keon Yon,George A Mensah,Brittany N Weber,Amy R Kontorovich,Sooji Lee,Leslie T Cooper,Enrico Ammirati
{"title":"Global epidemiology of myocarditis: disparities in age, sex and geography.","authors":"Karin Klingel,Carsten Tschöpe,Dong Keon Yon,George A Mensah,Brittany N Weber,Amy R Kontorovich,Sooji Lee,Leslie T Cooper,Enrico Ammirati","doi":"10.1038/s41569-026-01276-w","DOIUrl":"https://doi.org/10.1038/s41569-026-01276-w","url":null,"abstract":"Myocarditis is a clinically and aetiologically heterogeneous disease that is associated with substantial morbidity and mortality, with approximately a million new cases and 17,000 deaths annually worldwide. However, the incidence of myocarditis varies widely by geographical region, sex and age. The aetiology of myocarditis is multifactorial and shaped by regional, demographic and socioeconomic contexts. In high-income countries, parvovirus B19 and human herpesvirus 6 are the predominant cardiotropic viruses that induce lymphocytic myocarditis, particularly in children. By contrast, in low-to-middle-income countries, dengue virus, human immunodeficiency virus, Plasmodium spp. (malaria) and Trypanosoma cruzi (Chagas disease) are the most common causative pathogens. Systemic autoimmune conditions and genetic predisposition are also implicated in the development of myocarditis, and increasingly recognized iatrogenic triggers of myocarditis include immune checkpoint inhibitors and gene therapies. This Review synthesizes epidemiological insights across diverse age groups and geographical regions, with a particular emphasis on the undiagnosed disease burden in low-resource settings. Variability in diagnostic criteria and the scarcity of heart-biopsy-confirmed data pose challenges to accurate estimates of global prevalence. Priorities for future research include multicentric registries, multi-omics-based risk stratification, and integration of novel biomarkers and advanced imaging techniques to refine myocarditis surveillance and treatment, and improve the accuracy of disease burden estimates.","PeriodicalId":18976,"journal":{"name":"Nature Reviews Cardiology","volume":"15 1","pages":""},"PeriodicalIF":49.6,"publicationDate":"2026-03-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147518501","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Drug-coated balloon angioplasty for coronary and peripheral artery disease: latest evidence and clinical indications 药物包被球囊血管成形术治疗冠状动脉和外周动脉疾病：最新证据和临床适应症
IF 49.6 1区 医学
Nature Reviews Cardiology Pub Date : 2026-03-25 DOI: 10.1038/s41569-026-01262-2
Rory Durand, Daniel O’Callaghan, J. J. Coughlan, Salvatore Cassese, Robert A. Byrne
{"title":"Drug-coated balloon angioplasty for coronary and peripheral artery disease: latest evidence and clinical indications","authors":"Rory Durand, Daniel O’Callaghan, J. J. Coughlan, Salvatore Cassese, Robert A. Byrne","doi":"10.1038/s41569-026-01262-2","DOIUrl":"https://doi.org/10.1038/s41569-026-01262-2","url":null,"abstract":"","PeriodicalId":18976,"journal":{"name":"Nature Reviews Cardiology","volume":"405 1","pages":""},"PeriodicalIF":49.6,"publicationDate":"2026-03-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147506734","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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