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The molecular landscape of vascular cells in the human brain. 人脑中血管细胞的分子结构。
IF 49.6 1区 医学
Nature Reviews Cardiology Pub Date : 2024-09-20 DOI: 10.1038/s41569-024-01079-x
Elizabeth E Crouch
{"title":"The molecular landscape of vascular cells in the human brain.","authors":"Elizabeth E Crouch","doi":"10.1038/s41569-024-01079-x","DOIUrl":"https://doi.org/10.1038/s41569-024-01079-x","url":null,"abstract":"","PeriodicalId":18976,"journal":{"name":"Nature Reviews Cardiology","volume":null,"pages":null},"PeriodicalIF":49.6,"publicationDate":"2024-09-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142275211","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Lysosomes in the immunometabolic reprogramming of immune cells in atherosclerosis. 溶酶体在动脉粥样硬化免疫细胞免疫代谢重编程中的作用。
IF 49.6 1区 医学
Nature Reviews Cardiology Pub Date : 2024-09-20 DOI: 10.1038/s41569-024-01072-4
Fabrizia Bonacina,Xiangyu Zhang,Nicolas Manel,Laurent Yvan-Charvet,Babak Razani,Giuseppe D Norata
{"title":"Lysosomes in the immunometabolic reprogramming of immune cells in atherosclerosis.","authors":"Fabrizia Bonacina,Xiangyu Zhang,Nicolas Manel,Laurent Yvan-Charvet,Babak Razani,Giuseppe D Norata","doi":"10.1038/s41569-024-01072-4","DOIUrl":"https://doi.org/10.1038/s41569-024-01072-4","url":null,"abstract":"Lysosomes have a central role in the disposal of extracellular and intracellular cargo and also function as metabolic sensors and signalling platforms in the immunometabolic reprogramming of macrophages and other immune cells in atherosclerosis. Lysosomes can rapidly sense the presence of nutrients within immune cells, thereby switching from catabolism of extracellular material to the recycling of intracellular cargo. Such a fine-tuned degradative response supports the generation of metabolic building blocks through effectors such as mTORC1 or TFEB. By coupling nutrients to downstream signalling and metabolism, lysosomes serve as a crucial hub for cellular function in innate and adaptive immune cells. Lysosomal dysfunction is now recognized to be a hallmark of atherogenesis. Perturbations in nutrient-sensing and signalling have profound effects on the capacity of immune cells to handle cholesterol, perform phagocytosis and efferocytosis, and limit the activation of the inflammasome and other inflammatory pathways. Strategies to improve lysosomal function hold promise as novel modulators of the immunoinflammatory response associated with atherosclerosis. In this Review, we describe the crosstalk between lysosomal biology and immune cell function and polarization, with a particular focus on cellular immunometabolic reprogramming in the context of atherosclerosis.","PeriodicalId":18976,"journal":{"name":"Nature Reviews Cardiology","volume":null,"pages":null},"PeriodicalIF":49.6,"publicationDate":"2024-09-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142275210","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Finerenone improves outcomes in HFmrEF and HFpEF 非格列酮能改善高房颤mrEF和高房颤pEF的预后
IF 41.7 1区 医学
Nature Reviews Cardiology Pub Date : 2024-09-19 DOI: 10.1038/s41569-024-01087-x
Irene Fernández-Ruiz
{"title":"Finerenone improves outcomes in HFmrEF and HFpEF","authors":"Irene Fernández-Ruiz","doi":"10.1038/s41569-024-01087-x","DOIUrl":"10.1038/s41569-024-01087-x","url":null,"abstract":"The non-steroidal mineralocorticoid receptor antagonist finerenone reduces the risk of adverse outcomes in patients with heart failure with mildly reduced ejection fraction or with preserved ejection fraction, according to findings presented at the ESC Congress 2024.","PeriodicalId":18976,"journal":{"name":"Nature Reviews Cardiology","volume":null,"pages":null},"PeriodicalIF":41.7,"publicationDate":"2024-09-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142245408","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
TEER is non-inferior to surgery in patients with secondary mitral regurgitation 在继发性二尖瓣反流患者中，TEER 的疗效并不优于手术治疗
IF 41.7 1区 医学
Nature Reviews Cardiology Pub Date : 2024-09-19 DOI: 10.1038/s41569-024-01089-9
Irene Fernández-Ruiz
{"title":"TEER is non-inferior to surgery in patients with secondary mitral regurgitation","authors":"Irene Fernández-Ruiz","doi":"10.1038/s41569-024-01089-9","DOIUrl":"10.1038/s41569-024-01089-9","url":null,"abstract":"In patients with heart failure and secondary mitral valve regurgitation, transcatheter edge-to-edge repair is non-inferior to mitral valve surgery with respect to a composite of death, hospitalization for heart failure, reintervention, implantation of an assist device or stroke at 1 year after the procedure, according to findings from the MATTERHORN trial.","PeriodicalId":18976,"journal":{"name":"Nature Reviews Cardiology","volume":null,"pages":null},"PeriodicalIF":41.7,"publicationDate":"2024-09-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142245401","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Combining TAVI with PCI in patients with aortic stenosis and CAD 在主动脉瓣狭窄和 CAD 患者中将 TAVI 与 PCI 结合使用
IF 41.7 1区 医学
Nature Reviews Cardiology Pub Date : 2024-09-19 DOI: 10.1038/s41569-024-01080-4
Gregory B. Lim
{"title":"Combining TAVI with PCI in patients with aortic stenosis and CAD","authors":"Gregory B. Lim","doi":"10.1038/s41569-024-01080-4","DOIUrl":"10.1038/s41569-024-01080-4","url":null,"abstract":"In the NOTION-3 trial, percutaneous coronary intervention reduced the occurrence of major adverse cardiac events compared with conservative treatment in patients who were undergoing transcatheter aortic valve implantation for severe aortic stenosis and who had stable coronary artery disease.","PeriodicalId":18976,"journal":{"name":"Nature Reviews Cardiology","volume":null,"pages":null},"PeriodicalIF":41.7,"publicationDate":"2024-09-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142245407","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Benefit of vutrisiran in transthyretin amyloidosis with cardiomyopathy 经甲状腺素淀粉样变性伴心肌病患者服用武曲地兰的益处
IF 41.7 1区 医学
Nature Reviews Cardiology Pub Date : 2024-09-19 DOI: 10.1038/s41569-024-01086-y
Gregory B. Lim
{"title":"Benefit of vutrisiran in transthyretin amyloidosis with cardiomyopathy","authors":"Gregory B. Lim","doi":"10.1038/s41569-024-01086-y","DOIUrl":"10.1038/s41569-024-01086-y","url":null,"abstract":"Data from the HELIOS-B trial show that RNA interference with vutrisiran reduces the risk of death and recurrent cardiovascular events in patients with transthyretin amyloidosis with cardiomyopathy.","PeriodicalId":18976,"journal":{"name":"Nature Reviews Cardiology","volume":null,"pages":null},"PeriodicalIF":41.7,"publicationDate":"2024-09-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142245400","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Reproductive options and genetic testing for patients with an inherited cardiac disease 遗传性心脏病患者的生殖选择和基因检测
IF 49.6 1区 医学
Nature Reviews Cardiology Pub Date : 2024-09-17 DOI: 10.1038/s41569-024-01073-3
Job A. J. Verdonschot, Aimee D. C. Paulussen, Neal K. Lakdawala, Christine E. M. de Die-Smulders, James S. Ware, Jodie Ingles
{"title":"Reproductive options and genetic testing for patients with an inherited cardiac disease","authors":"Job A. J. Verdonschot, Aimee D. C. Paulussen, Neal K. Lakdawala, Christine E. M. de Die-Smulders, James S. Ware, Jodie Ingles","doi":"10.1038/s41569-024-01073-3","DOIUrl":"https://doi.org/10.1038/s41569-024-01073-3","url":null,"abstract":"<p>In the past decade, genetic testing for cardiac disease has become part of routine clinical care. A genetic diagnosis provides the possibility to clarify risk for relatives. For family planning, a genetic diagnosis provides reproductive options, including prenatal diagnosis and preimplantation genetic testing, that can prevent an affected parent from having a child with the genetic predisposition. Owing to the complex genetic architecture of cardiac diseases, characterized by incomplete disease penetrance and the interplay between monogenic and polygenic variants, the risk reduction that can be achieved using reproductive genetic testing varies among individuals. Globally, disparities, including regulatory and financial barriers, in access to reproductive genetic tests exist. Although reproductive options are gaining a prominent position in the management of patients with inherited cardiac diseases, specific policies and guidance are lacking. Guidelines recommend that prenatal diagnosis and preimplantation genetic testing are options that should be discussed with families. Health-care professionals should, therefore, be aware of the possibilities and feel confident to discuss the benefits and challenges. In this Review, we provide an overview of the reproductive options in the context of inherited cardiac diseases, covering the genetic, technical, psychosocial and equity considerations, to prepare health-care professionals for discussions with their patients.</p>","PeriodicalId":18976,"journal":{"name":"Nature Reviews Cardiology","volume":null,"pages":null},"PeriodicalIF":49.6,"publicationDate":"2024-09-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142235050","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Combined measure of inflammation, cholesterol and lipoprotein(a) predicts 30-year cardiovascular risk in women 综合衡量炎症、胆固醇和脂蛋白（a）可预测女性 30 年的心血管风险
IF 41.7 1区 医学
Nature Reviews Cardiology Pub Date : 2024-09-17 DOI: 10.1038/s41569-024-01082-2
Karina Huynh
{"title":"Combined measure of inflammation, cholesterol and lipoprotein(a) predicts 30-year cardiovascular risk in women","authors":"Karina Huynh","doi":"10.1038/s41569-024-01082-2","DOIUrl":"10.1038/s41569-024-01082-2","url":null,"abstract":"A single combined measurement of high-sensitivity C-reactive protein, LDL-cholesterol and lipoprotein(a) levels in plasma predicts incident cardiovascular events among women over a 30-year follow-up period, according to a new study.","PeriodicalId":18976,"journal":{"name":"Nature Reviews Cardiology","volume":null,"pages":null},"PeriodicalIF":41.7,"publicationDate":"2024-09-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142235046","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Clonal haematopoiesis: an emerging causal risk factor for atherosclerotic CVD 克隆性造血：动脉粥样硬化性心血管疾病的新致病风险因素
IF 41.7 1区 医学
Nature Reviews Cardiology Pub Date : 2024-09-17 DOI: 10.1038/s41569-024-01081-3
Jennifer Harman
{"title":"Clonal haematopoiesis: an emerging causal risk factor for atherosclerotic CVD","authors":"Jennifer Harman","doi":"10.1038/s41569-024-01081-3","DOIUrl":"10.1038/s41569-024-01081-3","url":null,"abstract":"New research suggests that the presence of clonal haematopoiesis is unidirectionally associated with the development of atherosclerosis and that colchicine holds potential therapeutic value.","PeriodicalId":18976,"journal":{"name":"Nature Reviews Cardiology","volume":null,"pages":null},"PeriodicalIF":41.7,"publicationDate":"2024-09-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142235047","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The gut microbiota in thrombosis 血栓形成中的肠道微生物群
IF 49.6 1区 医学
Nature Reviews Cardiology Pub Date : 2024-09-17 DOI: 10.1038/s41569-024-01070-6
My Phung Khuu, Nadja Paeslack, Olga Dremova, Corinne Benakis, Klytaimnistra Kiouptsi, Christoph Reinhardt
{"title":"The gut microbiota in thrombosis","authors":"My Phung Khuu, Nadja Paeslack, Olga Dremova, Corinne Benakis, Klytaimnistra Kiouptsi, Christoph Reinhardt","doi":"10.1038/s41569-024-01070-6","DOIUrl":"https://doi.org/10.1038/s41569-024-01070-6","url":null,"abstract":"<p>The gut microbiota has emerged as an environmental risk factor that affects thrombotic phenotypes in several cardiovascular diseases. Evidence includes the identification of marker species by sequencing studies of the gut microbiomes of patients with thrombotic disease, the influence of antithrombotic therapies on gut microbial diversity, and preclinical studies in mouse models of thrombosis that have demonstrated the functional effects of the gut microbiota on vascular inflammatory phenotypes and thrombus formation. In addition to impaired gut barrier function promoting low-grade inflammation, gut microbiota-derived metabolites have been shown to act on vascular cell types and promote thrombus formation. Therefore, these meta-organismal pathways that link the metabolic capacities of gut microorganisms with host immune functions have emerged as potential diagnostic markers and novel drug targets. In this Review, we discuss the link between the gut microbiota, its metabolites and thromboembolic diseases.</p>","PeriodicalId":18976,"journal":{"name":"Nature Reviews Cardiology","volume":null,"pages":null},"PeriodicalIF":49.6,"publicationDate":"2024-09-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142235049","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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