Endothelial cell metabolism in cardiovascular physiology and disease

IF 41.7 1区医学 Q1 CARDIAC & CARDIOVASCULAR SYSTEMS

Nature Reviews Cardiology Pub Date : 2025-05-09 DOI:10.1038/s41569-025-01162-x

Alessandra Pasut, Eleonora Lama, Amaryllis H. Van Craenenbroeck, Jeffrey Kroon, Peter Carmeliet

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Abstract

Endothelial cells are multifunctional cells that form the inner layer of blood vessels and have a crucial role in vasoreactivity, angiogenesis, immunomodulation, nutrient uptake and coagulation. Endothelial cells have unique metabolism and are metabolically heterogeneous. The microenvironment and metabolism of endothelial cells contribute to endothelial cell heterogeneity and metabolic specialization. Endothelial cell dysfunction is an early event in the development of several cardiovascular diseases and has been shown, at least to some extent, to be driven by metabolic changes preceding the manifestation of clinical symptoms. Diabetes mellitus, hypertension, obesity and chronic kidney disease are all risk factors for cardiovascular disease. Changes in endothelial cell metabolism induced by these cardiometabolic stressors accelerate the accumulation of dysfunctional endothelial cells in tissues and the development of cardiovascular disease. In this Review, we discuss the diversity of metabolic programmes that control endothelial cell function in the cardiovascular system and how these metabolic programmes are perturbed in different cardiovascular diseases in a disease-specific manner. Finally, we discuss the potential and challenges of targeting endothelial cell metabolism for the treatment of cardiovascular diseases.

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内皮细胞代谢在心血管生理和疾病中的作用

内皮细胞是形成血管内层的多功能细胞，在血管反应性、血管生成、免疫调节、营养摄取和凝血等方面起着至关重要的作用。内皮细胞具有独特的代谢和代谢异质性。内皮细胞的微环境和代谢导致了内皮细胞的异质性和代谢特化。内皮细胞功能障碍是几种心血管疾病发展的早期事件，至少在某种程度上，已被证明是由临床症状表现之前的代谢变化所驱动的。糖尿病、高血压、肥胖和慢性肾脏疾病都是心血管疾病的危险因素。这些心脏代谢应激源引起的内皮细胞代谢变化加速了功能失调的内皮细胞在组织中的积累和心血管疾病的发展。在这篇综述中，我们讨论了控制心血管系统内皮细胞功能的代谢程序的多样性，以及这些代谢程序如何在不同的心血管疾病中以疾病特异性的方式受到干扰。最后，我们讨论了靶向内皮细胞代谢治疗心血管疾病的潜力和挑战。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Nature Reviews Cardiology 医学-心血管系统

CiteScore

53.10

自引率

0.60%

发文量

143

审稿时长

6-12 weeks

期刊介绍： Nature Reviews Cardiology aims to be the go-to source for reviews and commentaries in the scientific and clinical communities it serves. Focused on providing authoritative and accessible articles enriched with clear figures and tables, the journal strives to offer unparalleled service to authors, referees, and readers, maximizing the usefulness and impact of each publication. It covers a broad range of content types, including Research Highlights, Comments, News & Views, Reviews, Consensus Statements, and Perspectives, catering to practising cardiologists and cardiovascular research scientists. Authored by renowned clinicians, academics, and researchers, the content targets readers in the biological and medical sciences, ensuring accessibility across various disciplines. In-depth Reviews offer up-to-date information, while Consensus Statements provide evidence-based recommendations. Perspectives and News & Views present topical discussions and opinions, and the Research Highlights section filters primary research from cardiovascular and general medical journals. As part of the Nature Reviews portfolio, Nature Reviews Cardiology maintains high standards and a wide reach.