从家族性高胆固醇血症中发现PSCK9的科学之旅

IF 41.7 1区医学 Q1 CARDIAC & CARDIOVASCULAR SYSTEMS

Nature Reviews Cardiology Pub Date : 2025-03-28 DOI:10.1038/s41569-025-01147-w

Marianne Abifadel

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引用次数: 0

摘要

全球各国在高胆固醇血症和心血管疾病的早期诊断和治疗方面面临重大挑战，存在许多按地域和收入划分的卫生不平等现象。毅力、勤奋、正直和承诺可以把愿望变成现实。我的PCSK9的故事就是一个真实的例子，从发现它与家族性高胆固醇血症的关系，到开发拯救生命的药物。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Scientific journey from PSCK9 discovery in familial hypercholesterolaemia

Countries globally face major challenges in the early diagnosis and treatment of hypercholesterolaemia and cardiovascular disease, with numerous health inequities by geography and income. Perseverance, hard work, integrity and commitment can transform aspiration into reality. My PCSK9 story, from the discovery of its implication in familial hypercholesterolemia to the development of life-saving drugs, is a real example.

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来源期刊

Nature Reviews Cardiology 医学-心血管系统

CiteScore

53.10

自引率

0.60%

发文量

143

审稿时长

6-12 weeks

期刊介绍： Nature Reviews Cardiology aims to be the go-to source for reviews and commentaries in the scientific and clinical communities it serves. Focused on providing authoritative and accessible articles enriched with clear figures and tables, the journal strives to offer unparalleled service to authors, referees, and readers, maximizing the usefulness and impact of each publication. It covers a broad range of content types, including Research Highlights, Comments, News & Views, Reviews, Consensus Statements, and Perspectives, catering to practising cardiologists and cardiovascular research scientists. Authored by renowned clinicians, academics, and researchers, the content targets readers in the biological and medical sciences, ensuring accessibility across various disciplines. In-depth Reviews offer up-to-date information, while Consensus Statements provide evidence-based recommendations. Perspectives and News & Views present topical discussions and opinions, and the Research Highlights section filters primary research from cardiovascular and general medical journals. As part of the Nature Reviews portfolio, Nature Reviews Cardiology maintains high standards and a wide reach.