Ceramides aggravate atherosclerosis via G protein-coupled receptor signalling

IF 41.7 1区医学 Q1 CARDIAC & CARDIOVASCULAR SYSTEMS

Nature Reviews Cardiology Pub Date : 2025-03-26 DOI:10.1038/s41569-025-01149-8

Irene Fernández-Ruiz

引用次数: 0

Abstract

A study published in Nature has identified two transmembrane G protein-coupled receptors that mediate extracellular-to-intracellular ceramide signalling and shows that blocking these receptors alleviates the atherosclerosis that is induced by a high-fat diet or aggravated by chronic kidney disease in mice.

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神经酰胺通过G蛋白偶联受体信号通路加重动脉粥样硬化

发表在《自然》杂志上的一项研究发现了两种介导细胞外到细胞内神经酰胺信号传导的跨膜G蛋白偶联受体，并表明阻断这些受体可减轻小鼠高脂肪饮食诱导或慢性肾脏疾病加重的动脉粥样硬化。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Nature Reviews Cardiology 医学-心血管系统

CiteScore

53.10

自引率

0.60%

发文量

143

审稿时长

6-12 weeks

期刊介绍： Nature Reviews Cardiology aims to be the go-to source for reviews and commentaries in the scientific and clinical communities it serves. Focused on providing authoritative and accessible articles enriched with clear figures and tables, the journal strives to offer unparalleled service to authors, referees, and readers, maximizing the usefulness and impact of each publication. It covers a broad range of content types, including Research Highlights, Comments, News & Views, Reviews, Consensus Statements, and Perspectives, catering to practising cardiologists and cardiovascular research scientists. Authored by renowned clinicians, academics, and researchers, the content targets readers in the biological and medical sciences, ensuring accessibility across various disciplines. In-depth Reviews offer up-to-date information, while Consensus Statements provide evidence-based recommendations. Perspectives and News & Views present topical discussions and opinions, and the Research Highlights section filters primary research from cardiovascular and general medical journals. As part of the Nature Reviews portfolio, Nature Reviews Cardiology maintains high standards and a wide reach.