Endothelial cell necroptosis induces haemolysis and microangiopathy

Endothelial cells in ischaemic microvessels undergo necroptosis, which is linked to haemolysis and the deposition of haemolysed red blood cell membranes at the sites of endothelial cell death. This process might be a haemostatic mechanism to prevent interstitial bleeding; however, excessive aggregation can cause microvascular obstruction and microangiopathy.