Nature cancerPub Date : 2024-12-17DOI: 10.1038/s43018-024-00834-w
Julieta Alfonso
{"title":"Adjusting the clock for cancer immunotherapy","authors":"Julieta Alfonso","doi":"10.1038/s43018-024-00834-w","DOIUrl":"10.1038/s43018-024-00834-w","url":null,"abstract":"","PeriodicalId":18885,"journal":{"name":"Nature cancer","volume":"5 12","pages":"1781-1781"},"PeriodicalIF":23.5,"publicationDate":"2024-12-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142846994","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Nature cancerPub Date : 2024-12-17DOI: 10.1038/s43018-024-00867-1
Céline Grégoire, J. Joseph Melenhorst
{"title":"Navigating CAR-T cell therapy long-term complications","authors":"Céline Grégoire, J. Joseph Melenhorst","doi":"10.1038/s43018-024-00867-1","DOIUrl":"10.1038/s43018-024-00867-1","url":null,"abstract":"Chimeric antigen receptor (CAR)-T cells have revolutionized the treatment of hematological malignancies; however long-term safety concerns, associated with infections and secondary malignancies, have been reported. Here we discuss the clinical challenges of CAR-T cell therapy in light of this emerging benefit–risk controversy.","PeriodicalId":18885,"journal":{"name":"Nature cancer","volume":"5 12","pages":"1768-1770"},"PeriodicalIF":23.5,"publicationDate":"2024-12-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142847093","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Nature cancerPub Date : 2024-12-17DOI: 10.1038/s43018-024-00861-7
Yongju Lee, Dyke Ferber, Jennifer E. Rood, Aviv Regev, Jakob Nikolas Kather
{"title":"How AI agents will change cancer research and oncology","authors":"Yongju Lee, Dyke Ferber, Jennifer E. Rood, Aviv Regev, Jakob Nikolas Kather","doi":"10.1038/s43018-024-00861-7","DOIUrl":"10.1038/s43018-024-00861-7","url":null,"abstract":"Deep learning models are advancing cancer research and oncology but require human engagement to perform complex multi-step workflows. Autonomous artificial intelligence agents, empowered by large language models, present a promising solution by enabling the planning, execution and optimization of multi-step reasoning in biomedical research.","PeriodicalId":18885,"journal":{"name":"Nature cancer","volume":"5 12","pages":"1765-1767"},"PeriodicalIF":23.5,"publicationDate":"2024-12-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142847089","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Nature cancerPub Date : 2024-12-17DOI: 10.1038/s43018-024-00860-8
Rigel J. Kishton, Nicholas P. Restifo
{"title":"T cells lead the charge against solid tumors","authors":"Rigel J. Kishton, Nicholas P. Restifo","doi":"10.1038/s43018-024-00860-8","DOIUrl":"10.1038/s43018-024-00860-8","url":null,"abstract":"In 2024, two groundbreaking approvals from the US Food and Drug Administration for T cell-based therapies that target solid tumors were achieved. Lifileucel, a polyclonal tumor-infiltrating lymphocyte-based product for melanoma, and afamitresgene autoleucel, a gene-engineered T cell receptor product for sarcoma, mark a major shift from the six chimeric antigen receptor T cell therapies previously approved for hematological malignancies.","PeriodicalId":18885,"journal":{"name":"Nature cancer","volume":"5 12","pages":"1762-1764"},"PeriodicalIF":23.5,"publicationDate":"2024-12-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142847098","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Nature cancerPub Date : 2024-12-17DOI: 10.1038/s43018-024-00885-z
{"title":"The highs and lows of 2024","authors":"","doi":"10.1038/s43018-024-00885-z","DOIUrl":"10.1038/s43018-024-00885-z","url":null,"abstract":"The Nature Cancer editorial team presents a Focus issue on the most interesting developments of 2024, with commissioned commentary and highlights from the literature in our journal and elsewhere.","PeriodicalId":18885,"journal":{"name":"Nature cancer","volume":"5 12","pages":"1755-1755"},"PeriodicalIF":23.5,"publicationDate":"2024-12-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.nature.com/articles/s43018-024-00885-z.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142847100","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Nature cancerPub Date : 2024-12-17DOI: 10.1038/s43018-024-00866-2
Shruthy Suresh Aggarwal, Cristina Andreani, Zihou Deng, Julia Frede, Polina Kameneva, Marta Kovatcheva, Goran Micevic, Fay Nicolson, Jens Puschhof, Morgan Roberts, Gang Wang, Dionysios C. Watson
{"title":"The 2024 generation","authors":"Shruthy Suresh Aggarwal, Cristina Andreani, Zihou Deng, Julia Frede, Polina Kameneva, Marta Kovatcheva, Goran Micevic, Fay Nicolson, Jens Puschhof, Morgan Roberts, Gang Wang, Dionysios C. Watson","doi":"10.1038/s43018-024-00866-2","DOIUrl":"10.1038/s43018-024-00866-2","url":null,"abstract":"Twelve early-career researchers who embarked on their independent research paths in 2024 reflect on their experience from their journey so far, describe the opportunities they received and the challenges they faced, and share their hopes and plans for the future.","PeriodicalId":18885,"journal":{"name":"Nature cancer","volume":"5 12","pages":"1774-1778"},"PeriodicalIF":23.5,"publicationDate":"2024-12-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142847099","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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