Nature cancer最新文献_第4页

Coordination of cell subsets in health and cancer 健康和癌症中细胞亚群的协调。

IF 28.5 1区医学

Nature cancer Pub Date : 2025-07-30 DOI: 10.1038/s43018-025-01028-8

Tiffanie Chouleur

引用次数: 0

Author Correction: IL-17A-secreting γδ T cells promote resistance to CDK4/CDK6 inhibitors in HR⁺HER2^- breast cancer via CX3CR1⁺ macrophages. 作者更正：分泌il - 17a的γδ T细胞通过CX3CR1+巨噬细胞促进HR+HER2乳腺癌对CDK4/CDK6抑制剂的抗性。

IF 23.5 1区医学

Nature cancer Pub Date : 2025-07-23 DOI: 10.1038/s43018-025-01036-8

Giulia Petroni, Claudia Galassi, Kenneth H Gouin, Hsiang-Han Chen, Aitziber Buqué, Norma Bloy, Takahiro Yamazaki, Ai Sato, Manuel Beltrán-Visiedo, Ginevra Campia, Carlos Jiménez-Cortegana, Aagam Shah, Alexander Kirchmair, Chiara Massa, Claudia Wickenhauser, Carlos Eduardo de Andrea, Belén Navarro-Rubio, Irantzu Serrano-Mendioroz, Esther Navarro Manzano, Alexandra M Satty, Brady Rippon, Francesca Finotello, Zlatko Trajanoski, Xi Kathy Zhou, Joseph M Scandura, Elena García-Martínez, Francisco Ayala de la Peña, María Esperanza Rodríguez-Ruiz, Barbara Seliger, Víctor Sánchez-Margalet, Luis de la Cruz-Merino, Reva K Basho, Stephen L Shiao, Heather L McArthur, Silvia C Formenti, Simon R V Knott, Lorenzo Galluzzi

引用次数: 0

Author Correction: Autotaxin–lysolipid signaling suppresses a CCL11–eosinophil axis to promote pancreatic cancer progression 作者更正：自噬素溶脂信号抑制ccl11 -嗜酸性粒细胞轴促进胰腺癌进展。

IF 28.5 1区医学

Nature cancer Pub Date : 2025-07-23 DOI: 10.1038/s43018-025-01035-9

Sohinee Bhattacharyya, Chet Oon, Luis Diaz, Holly Sandborg, Erin S. Stempinski, Michelle Saoi, Terry K. Morgan, Claudia S. López, Justin R. Cross, Mara H. Sherman

引用次数: 0

Combination of pembrolizumab and radiotherapy induces systemic antitumor immune responses in immunologically cold non-small cell lung cancer. 派姆单抗联合放疗可诱导免疫冷性非小细胞肺癌的全身抗肿瘤免疫反应。

IF 28.5 1区医学

Nature cancer Pub Date : 2025-07-22 DOI: 10.1038/s43018-025-01018-w

Justin Huang, Willemijn S M E Theelen, Zineb Belcaid, Mimi Najjar, Daphne van der Geest, Dipika Singh, Christopher Cherry, Archana Balan, James R White, Jaime Wehr, Rachel Karchin, Noushin Niknafs, Michel M van den Heuvel, Victor E Velculescu, Kellie N Smith, Paul Baas, Valsamo Anagnostou

{"title":"Combination of pembrolizumab and radiotherapy induces systemic antitumor immune responses in immunologically cold non-small cell lung cancer.","authors":"Justin Huang, Willemijn S M E Theelen, Zineb Belcaid, Mimi Najjar, Daphne van der Geest, Dipika Singh, Christopher Cherry, Archana Balan, James R White, Jaime Wehr, Rachel Karchin, Noushin Niknafs, Michel M van den Heuvel, Victor E Velculescu, Kellie N Smith, Paul Baas, Valsamo Anagnostou","doi":"10.1038/s43018-025-01018-w","DOIUrl":"10.1038/s43018-025-01018-w","url":null,"abstract":"The abscopal effects of radiation may sensitize immunologically cold tumors to immune checkpoint inhibition. We investigated the immunostimulatory effects of radiotherapy leveraging multiomic analyses of serial tissue and blood biospecimens (n = 293) from a phase 2 clinical trial of stereotactic body radiation therapy (SBRT) followed by pembrolizumab in metastatic non-small cell lung cancer ( NCT02492568 ). Participants with immunologically cold tumors (low tumor mutation burden, null programmed death ligand 1 expression or Wnt pathway mutations) had significantly longer progression-free survival in the SBRT arm. Induction of interferon-γ, interferon-α and antigen processing and presentation gene sets was significantly enriched after SBRT in nonirradiated tumor sites. Significant on-therapy expansions of new and pre-existing T cell clones in both the tumor (abscopal) and the blood (systemic) compartments were noted alongside clonal neoantigen-reactive autologous T cell responses in participants with long-term survival after radioimmunotherapy. These findings support the systemic immunomodulatory and antitumor effects of radioimmunotherapy and may open a therapeutic window of opportunity to overcome immunotherapy resistance.","PeriodicalId":18885,"journal":{"name":"Nature cancer","volume":" ","pages":""},"PeriodicalIF":28.5,"publicationDate":"2025-07-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144691028","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

CAR-engineered lymphocyte persistence is governed by a FAS ligand-FAS autoregulatory circuit. car工程淋巴细胞持久性由FAS配体-FAS自动调节回路控制。

IF 28.5 1区医学

Nature cancer Pub Date : 2025-07-22 DOI: 10.1038/s43018-025-01009-x

Fei Yi, Tal Cohen, Natalie Zimmerman, Friederike Dündar, Paul Zumbo, Razan Eltilib, Erica J Brophy, Hannah Arkin, Judith Feucht, Michael V Gormally, Christopher S Hackett, Korbinian N Kropp, Inaki Etxeberria, Smita S Chandran, Zeguo Zhao, Winson Cai, Anthony F Daniyan, Jae H Park, Caleb A Lareau, Katharine C Hsu, Michel Sadelain, Doron Betel, Christopher A Klebanoff

{"title":"CAR-engineered lymphocyte persistence is governed by a FAS ligand-FAS autoregulatory circuit.","authors":"Fei Yi, Tal Cohen, Natalie Zimmerman, Friederike Dündar, Paul Zumbo, Razan Eltilib, Erica J Brophy, Hannah Arkin, Judith Feucht, Michael V Gormally, Christopher S Hackett, Korbinian N Kropp, Inaki Etxeberria, Smita S Chandran, Zeguo Zhao, Winson Cai, Anthony F Daniyan, Jae H Park, Caleb A Lareau, Katharine C Hsu, Michel Sadelain, Doron Betel, Christopher A Klebanoff","doi":"10.1038/s43018-025-01009-x","DOIUrl":"10.1038/s43018-025-01009-x","url":null,"abstract":"Chimeric antigen receptor (CAR)-engineered lymphocytes treat B cell malignancies; however, limited persistence can restrain the full therapeutic potential of this approach. FAS ligand (FAS-L)/FAS interactions govern lymphocyte homeostasis. Knowledge of which cells express FAS-L in patients with cancer and whether these sources compromise CAR persistence remains incomplete. Here, we constructed a single-cell atlas of diverse cancers to identify cellular subsets expressing FASLG, the gene encoding FAS-L. We discovered that FASLG expression is limited primarily to endogenous T cells, natural killer (NK) cells and CAR-T cells, while tumor and stromal cell expression is minimal. To establish whether CAR-T and CAR-NK cell survival is FAS-L regulated, we performed competitive fitness assays using FAS-dominant negative receptor (ΔFAS)-modified lymphocytes. Following transfer, ΔFAS-expressing CAR-T/CAR-NK cells became enriched, a phenomenon that mechanistically was reverted through FASLG knockout. By contrast, FASLG was dispensable for CAR-mediated tumor killing. In multiple models in female mice, ΔFAS coexpression enhanced antitumor efficacy. Together, these findings reveal that CAR-engineered lymphocyte persistence is governed by a FAS-L/FAS autoregulatory circuit.","PeriodicalId":18885,"journal":{"name":"Nature cancer","volume":" ","pages":""},"PeriodicalIF":28.5,"publicationDate":"2025-07-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144691027","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Convergence of hypoxic stress population adaptation and hypoxic tumor growth 低氧应激群体适应与低氧肿瘤生长的趋同。

IF 28.5 1区医学

Nature cancer Pub Date : 2025-07-18 DOI: 10.1038/s43018-025-01027-9

Eleni Skourti

引用次数: 0

Clonal hematopoiesis in myeloid malignancies and solid tumors 骨髓恶性肿瘤和实体瘤的克隆造血。

IF 28.5 1区医学

Nature cancer Pub Date : 2025-07-18 DOI: 10.1038/s43018-025-01014-0

Xiurong Cai, Robert L. Bowman, Jennifer J. Trowbridge

引用次数: 0

The landscape of CAR-engineered innate immune cells for cancer immunotherapy car -工程先天免疫细胞用于癌症免疫治疗的前景。