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Author Correction: Scribble mis-localization induces adaptive resistance to KRAS G12C inhibitors through feedback activation of MAPK signaling mediated by YAP-induced MRAS. 作者更正：Scribble错误定位通过yap诱导的MRAS介导的MAPK信号反馈激活诱导对KRAS G12C抑制剂的适应性抗性。
IF 28 1区 医学
Nature cancer Pub Date : 2026-10-19 DOI: 10.1038/s43018-026-01273-5
Yuta Adachi, Ryo Kimura, Kentaro Hirade, Shogo Yanase, Yuki Nishioka, Natsumi Kasuga, Rui Yamaguchi, Hiromichi Ebi
{"title":"Author Correction: Scribble mis-localization induces adaptive resistance to KRAS G12C inhibitors through feedback activation of MAPK signaling mediated by YAP-induced MRAS.","authors":"Yuta Adachi, Ryo Kimura, Kentaro Hirade, Shogo Yanase, Yuki Nishioka, Natsumi Kasuga, Rui Yamaguchi, Hiromichi Ebi","doi":"10.1038/s43018-026-01273-5","DOIUrl":"https://doi.org/10.1038/s43018-026-01273-5","url":null,"abstract":"","PeriodicalId":18885,"journal":{"name":"Nature cancer","volume":" ","pages":""},"PeriodicalIF":28.0,"publicationDate":"2026-10-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149224459","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Stroke-induced astrocyte memories promote glioma progression. 中风诱导的星形胶质细胞记忆促进胶质瘤的进展。
IF 28 1区 医学
Nature cancer Pub Date : 2026-10-14 DOI: 10.1038/s43018-026-01251-x
Brian M Andersen, Francisco J Quintana
{"title":"Stroke-induced astrocyte memories promote glioma progression.","authors":"Brian M Andersen, Francisco J Quintana","doi":"10.1038/s43018-026-01251-x","DOIUrl":"https://doi.org/10.1038/s43018-026-01251-x","url":null,"abstract":"","PeriodicalId":18885,"journal":{"name":"Nature cancer","volume":" ","pages":""},"PeriodicalIF":28.0,"publicationDate":"2026-10-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149182937","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Reframing cancer therapy through tumor plasticity. 通过肿瘤可塑性重构癌症治疗。
IF 28 1区 医学
Nature cancer Pub Date : 2026-10-14 DOI: 10.1038/s43018-026-01232-0
Akansha M Shah, Bryan P Marsh, Frederic J de Sauvage
{"title":"Reframing cancer therapy through tumor plasticity.","authors":"Akansha M Shah, Bryan P Marsh, Frederic J de Sauvage","doi":"10.1038/s43018-026-01232-0","DOIUrl":"https://doi.org/10.1038/s43018-026-01232-0","url":null,"abstract":"<p><p>A major barrier to cancer therapy is the emergence of drug-tolerant states that allow tumor cells to bypass the targeted pathway. These refractory states arise through reversible cellular plasticity, a process that also occurs during development and regeneration, giving rise to new lineages or phenotypes and restoring drug sensitivity upon treatment withdrawal. Over time, genetic mutations may accumulate, leading to permanent resistance. This paradigm expands the focus from targeting genetic mechanisms alone to also exploiting nongenetic vulnerabilities, driving clinical strategies that prevent or eliminate plastic and transformed populations. Here, we provide an overview of nongenetic plasticity mechanisms and their emerging clinical applications.</p>","PeriodicalId":18885,"journal":{"name":"Nature cancer","volume":" ","pages":""},"PeriodicalIF":28.0,"publicationDate":"2026-10-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149182991","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Author Correction: A first-in-class selective inhibitor of EGFR and PI3K offers a single-molecule approach to targeting adaptive resistance. 作者更正：一种一流的EGFR和PI3K选择性抑制剂提供了一种靶向适应性耐药的单分子方法。
IF 28 1区 医学
Nature cancer Pub Date : 2026-10-12 DOI: 10.1038/s43018-026-01269-1
Christopher E Whitehead, Elizabeth K Ziemke, Christy L Frankowski-McGregor, Rachel A Mumby, June Chung, Jinju Li, Nathaniel Osher, Oluwadara Coker, Veerabhadran Baladandayuthapani, Scott Kopetz, Judith S Sebolt-Leopold
{"title":"Author Correction: A first-in-class selective inhibitor of EGFR and PI3K offers a single-molecule approach to targeting adaptive resistance.","authors":"Christopher E Whitehead, Elizabeth K Ziemke, Christy L Frankowski-McGregor, Rachel A Mumby, June Chung, Jinju Li, Nathaniel Osher, Oluwadara Coker, Veerabhadran Baladandayuthapani, Scott Kopetz, Judith S Sebolt-Leopold","doi":"10.1038/s43018-026-01269-1","DOIUrl":"https://doi.org/10.1038/s43018-026-01269-1","url":null,"abstract":"","PeriodicalId":18885,"journal":{"name":"Nature cancer","volume":" ","pages":""},"PeriodicalIF":28.0,"publicationDate":"2026-10-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149169848","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Author Correction: PAK4 inhibition improves PD-1 blockade immunotherapy. 作者更正：PAK4抑制改善PD-1阻断免疫治疗。
IF 28 1区 医学
Nature cancer Pub Date : 2026-10-09 DOI: 10.1038/s43018-026-01268-2
Gabriel Abril-Rodriguez, Davis Y Torrejon, Wei Liu, Jesse M Zaretsky, Theodore S Nowicki, Jennifer Tsoi, Cristina Puig-Saus, Ignacio Baselga-Carretero, Egmidio Medina, Michael J Quist, Alejandro J Garcia, William Senapedis, Erkan Baloglu, Anusha Kalbasi, Gardenia Cheung-Lau, Beata Berent-Maoz, Begoña Comin-Anduix, Siwen Hu-Lieskovan, Cun-Yu Wang, Catherine S Grasso, Antoni Ribas
{"title":"Author Correction: PAK4 inhibition improves PD-1 blockade immunotherapy.","authors":"Gabriel Abril-Rodriguez, Davis Y Torrejon, Wei Liu, Jesse M Zaretsky, Theodore S Nowicki, Jennifer Tsoi, Cristina Puig-Saus, Ignacio Baselga-Carretero, Egmidio Medina, Michael J Quist, Alejandro J Garcia, William Senapedis, Erkan Baloglu, Anusha Kalbasi, Gardenia Cheung-Lau, Beata Berent-Maoz, Begoña Comin-Anduix, Siwen Hu-Lieskovan, Cun-Yu Wang, Catherine S Grasso, Antoni Ribas","doi":"10.1038/s43018-026-01268-2","DOIUrl":"https://doi.org/10.1038/s43018-026-01268-2","url":null,"abstract":"","PeriodicalId":18885,"journal":{"name":"Nature cancer","volume":" ","pages":""},"PeriodicalIF":28.0,"publicationDate":"2026-10-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149148584","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Intestinal epithelial GSK3β governs fumarate-dependent neutrophil reprogramming to promote colorectal cancer. 肠上皮GSK3β调控富马酸依赖的中性粒细胞重编程以促进结直肠癌。
IF 28 1区 医学
Nature cancer Pub Date : 2026-10-06 DOI: 10.1038/s43018-026-01253-9
Xiao-Shun He, Xiao-Qin Yang, Shan Wan, Yun Yang, Wen-Juan Gan, Yi-Xuan Liu, Zu-Da Pan, Hai-Yi Zhang, Kuang He, Xin Guo, Juan Liu, Zhi Jiang, Wen-Xin Wu, Feng Liu, Yue-Yue Wu, Yuan-Meng Hu, Ruo-Yang Zhang, Shuo Jiang, Wei-Wei Sun, Yan-Ru Wang, Hua Wu
{"title":"Intestinal epithelial GSK3β governs fumarate-dependent neutrophil reprogramming to promote colorectal cancer.","authors":"Xiao-Shun He, Xiao-Qin Yang, Shan Wan, Yun Yang, Wen-Juan Gan, Yi-Xuan Liu, Zu-Da Pan, Hai-Yi Zhang, Kuang He, Xin Guo, Juan Liu, Zhi Jiang, Wen-Xin Wu, Feng Liu, Yue-Yue Wu, Yuan-Meng Hu, Ruo-Yang Zhang, Shuo Jiang, Wei-Wei Sun, Yan-Ru Wang, Hua Wu","doi":"10.1038/s43018-026-01253-9","DOIUrl":"https://doi.org/10.1038/s43018-026-01253-9","url":null,"abstract":"<p><p>Tumor-infiltrating neutrophils (TINs) promote colorectal cancer progression and therapeutic resistance, but their reprogramming mechanisms remain unclear. Using mouse models and multiomics profiling, we reveal that intestinal epithelial glycogen synthase kinase-3-β (GSK3β) orchestrates fumarate-dependent TIN polarization. GSK3β-primed T3 neutrophils express FTH1 and PD-L1, conferring ferroptosis resistance and immune evasion. Mechanistically, nuclear GSK3β phosphorylates linker histone H1FX, triggering its proteasomal degradation via USP43 dissociation and elevating chromatin accessibility for glycolytic gene transcription. Lactate inactivates fumarate hydratase through lactylation, driving intratumoral fumarate accumulation. Fumarate inhibits KDM2B activity in TINs, elevating histone H3 lysine 36 dimethylation to trigger epigenetic reprogramming toward immunosuppressive T3 neutrophils. Pharmacological GSK3β inhibition with tideglusib attenuates T3 polarization and potentiates checkpoint blockade in preclinical colorectal cancer models. Our work establishes a metabolic-epigenetic axis controlling TIN reprogramming and suggests combinatorial immunotherapies for CRC.</p>","PeriodicalId":18885,"journal":{"name":"Nature cancer","volume":" ","pages":""},"PeriodicalIF":28.0,"publicationDate":"2026-10-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149112363","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
A breakthrough in p53-targeted therapy. p53靶向治疗的突破。
IF 28 1区 医学
Nature cancer Pub Date : 2026-10-01 DOI: 10.1038/s43018-026-01254-8
Klas G Wiman
{"title":"A breakthrough in p53-targeted therapy.","authors":"Klas G Wiman","doi":"10.1038/s43018-026-01254-8","DOIUrl":"https://doi.org/10.1038/s43018-026-01254-8","url":null,"abstract":"","PeriodicalId":18885,"journal":{"name":"Nature cancer","volume":" ","pages":""},"PeriodicalIF":28.0,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149112358","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
From task-specific tools to a universal foundation model for cytology. 从特定任务工具到细胞学通用基础模型。
IF 28 1区 医学
Nature cancer Pub Date : 2026-09-29 DOI: 10.1038/s43018-026-01239-7
{"title":"From task-specific tools to a universal foundation model for cytology.","authors":"","doi":"10.1038/s43018-026-01239-7","DOIUrl":"https://doi.org/10.1038/s43018-026-01239-7","url":null,"abstract":"","PeriodicalId":18885,"journal":{"name":"Nature cancer","volume":" ","pages":""},"PeriodicalIF":28.0,"publicationDate":"2026-09-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149081513","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Unraveling the lexicon of complex mutational phenomena in human cancers. 揭示人类癌症中复杂突变现象的词典。
IF 28 1区 医学
Nature cancer Pub Date : 2026-09-25 DOI: 10.1038/s43018-026-01242-y
Ting Yang, Erik N Bergstrom, Stanley Clarke, Marcin Imieliński, Ludmil B Alexandrov
{"title":"Unraveling the lexicon of complex mutational phenomena in human cancers.","authors":"Ting Yang, Erik N Bergstrom, Stanley Clarke, Marcin Imieliński, Ludmil B Alexandrov","doi":"10.1038/s43018-026-01242-y","DOIUrl":"https://doi.org/10.1038/s43018-026-01242-y","url":null,"abstract":"<p><p>Although most mutations found in cancer genomes are randomly distributed, some form complex genomic patterns. Over the past 15 years, genomics studies have systematically uncovered multiple mutational phenomena, assigning several of them evocative Greek terms including kataegis, omikli, kyklonas, chromothripsis, chromoplexy, pyrgo, rigma and tyfonas. These phenomena are associated with distinct, often incompletely understood, molecular mechanisms and have important implications for tumor evolution and clinical outcomes. This Perspective provides a comprehensive lexicon of these mutational phenomena, addressing ambiguities in their definitions and mechanisms while highlighting their diversity, proposed origins and known associations with mutational processes, drug resistance and clinical outcomes.</p>","PeriodicalId":18885,"journal":{"name":"Nature cancer","volume":" ","pages":""},"PeriodicalIF":28.0,"publicationDate":"2026-09-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149062896","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Stroke drives glioma progression through the emergence of tumor-associated astrocytes with reduced Ca2+ activity. 中风通过出现与肿瘤相关的星形胶质细胞降低Ca2+活性来驱动胶质瘤的进展。
IF 28 1区 医学
Nature cancer Pub Date : 2026-09-25 DOI: 10.1038/s43018-026-01238-8
Qi Ye, Christine Madamba, Junsung Woo, Tiffany J Choy, Kate F Wheeler, Jiangshan Zhan, Carlo D Cristobal, Catalina Spjut, Donghui Shin, Juyeon Jo, Roshan R Ailani, Joshua Smith, Khatri Latha, Akdes Serin Harmanci, Hari Krishna Yalamanchili, Marco Gallo, Kyuson Yun, Yana K Reshetnyak, Eunhee Kim, Yongsoo Kim, Ganesh Rao, Benjamin Deneen, Hyun Kyoung Lee
{"title":"Stroke drives glioma progression through the emergence of tumor-associated astrocytes with reduced Ca<sup>2+</sup> activity.","authors":"Qi Ye, Christine Madamba, Junsung Woo, Tiffany J Choy, Kate F Wheeler, Jiangshan Zhan, Carlo D Cristobal, Catalina Spjut, Donghui Shin, Juyeon Jo, Roshan R Ailani, Joshua Smith, Khatri Latha, Akdes Serin Harmanci, Hari Krishna Yalamanchili, Marco Gallo, Kyuson Yun, Yana K Reshetnyak, Eunhee Kim, Yongsoo Kim, Ganesh Rao, Benjamin Deneen, Hyun Kyoung Lee","doi":"10.1038/s43018-026-01238-8","DOIUrl":"10.1038/s43018-026-01238-8","url":null,"abstract":"<p><p>Epidemiological studies suggest that persons with a history of stroke are at increased risk of developing brain tumors, yet the mechanisms linking brain injury to glioma progression remain unclear. Here we show that stroke promotes tumor infiltration into injured brain regions in human and mouse glioma models, accompanied by reduced overall survival. Stroke induces remodeling of the tumor microenvironment, including the emergence of a distinct population of tumor-associated astrocytes (TAAs) with diminished Ca<sup>2+</sup> activity at the invasive front and enrichment of tumor-associated microglia and macrophages (TAMs). Restoring TAA Ca<sup>2+</sup> signaling or TAM depletion suppresses stroke-induced glioma progression, identifying both populations as critical mediators of the injury response. Mechanistically, we identified SLC4A4 as a key regulator of Ca<sup>2+</sup> activity in TAAs and CCL2-mediated TAM recruitment. Collectively, our findings establish stroke-induced remodeling of astrocytic Ca<sup>2+</sup> signaling and TAMs as drivers of glioma progression and link brain injury to malignant disease.</p>","PeriodicalId":18885,"journal":{"name":"Nature cancer","volume":" ","pages":""},"PeriodicalIF":28.0,"publicationDate":"2026-09-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149062869","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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