骨髓恶性肿瘤和实体瘤的克隆造血。

IF 23.5 1区医学 Q1 ONCOLOGY

Nature cancer Pub Date : 2025-07-18 DOI:10.1038/s43018-025-01014-0

Xiurong Cai, Robert L Bowman, Jennifer J Trowbridge

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引用次数: 0

摘要

克隆造血是造血干细胞克隆扩增的结果。在特定情况下，CH与实体瘤患者患血癌和死亡率的风险增加有关。为了了解这种关联的机制和临床意义，探索CH和癌症之间的相互关系至关重要。在这里，我们提供了一个最新的机制总结已知驱动CH在血癌和实体瘤。此外，我们回顾了拦截CH的建议策略，并检查了它们对实体肿瘤定向治疗的影响，包括免疫刺激治疗。

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Clonal hematopoiesis in myeloid malignancies and solid tumors.

Clonal hematopoiesis (CH) results from clonal expansion of hematopoietic stem cells. In specific contexts, CH is linked with an increased risk of blood cancers and mortality in individuals with solid tumors. To understand the mechanisms and clinical relevance of this association, it is crucial to explore the reciprocal relationship between CH and cancer. Here, we provide an updated summary of the mechanisms known to drive CH in blood cancers and solid tumors. In addition, we review proposed strategies to intercept CH and examine their impact on solid tumor-directed therapies, including immunostimulatory therapies.

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来源期刊

Nature cancer Medicine-Oncology

CiteScore

31.10

自引率

1.80%

发文量

129

期刊介绍： Cancer is a devastating disease responsible for millions of deaths worldwide. However, many of these deaths could be prevented with improved prevention and treatment strategies. To achieve this, it is crucial to focus on accurate diagnosis, effective treatment methods, and understanding the socioeconomic factors that influence cancer rates. Nature Cancer aims to serve as a unique platform for sharing the latest advancements in cancer research across various scientific fields, encompassing life sciences, physical sciences, applied sciences, and social sciences. The journal is particularly interested in fundamental research that enhances our understanding of tumor development and progression, as well as research that translates this knowledge into clinical applications through innovative diagnostic and therapeutic approaches. Additionally, Nature Cancer welcomes clinical studies that inform cancer diagnosis, treatment, and prevention, along with contributions exploring the societal impact of cancer on a global scale. In addition to publishing original research, Nature Cancer will feature Comments, Reviews, News & Views, Features, and Correspondence that hold significant value for the diverse field of cancer research.