Nature cancerPub Date : 2025-01-02DOI: 10.1038/s43018-024-00872-4
Brian Keith, Danny R Welch, Nishtha Agarwal, Caroline Blair, Ifeanyi Beverly Chukwudozie, Lalita A Shevde, Lawrence H Boise, Kerry L Burnstein, Toni M Antalis, Kathleen L O'Connor, Sorab N Dalal, Sheridan Ellis, Harikrishna Nakshatri
{"title":"Challenges and opportunities in training cancer researchers.","authors":"Brian Keith, Danny R Welch, Nishtha Agarwal, Caroline Blair, Ifeanyi Beverly Chukwudozie, Lalita A Shevde, Lawrence H Boise, Kerry L Burnstein, Toni M Antalis, Kathleen L O'Connor, Sorab N Dalal, Sheridan Ellis, Harikrishna Nakshatri","doi":"10.1038/s43018-024-00872-4","DOIUrl":"https://doi.org/10.1038/s43018-024-00872-4","url":null,"abstract":"","PeriodicalId":18885,"journal":{"name":"Nature cancer","volume":" ","pages":""},"PeriodicalIF":23.5,"publicationDate":"2025-01-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142922103","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Nature cancerPub Date : 2024-12-20DOI: 10.1038/s43018-024-00858-2
Jiaxu Zhao, Rui Zeng, Xiaohui Li, Ying Lu, Zuoyun Wang, Haibao Peng, Hao Chen, Minjie Fu, Ye Zhang, Yang Huang, Wenhan Chen, Xin Wang, Yun Guan, Wei Han, Ruofan Huang, Chengjun Yao, Zhiyong Qin, Lingchao Chen, Liang Chen, Xue Feng, Hanting Yang, Patrícia M. R. Pereira, Xuemei Tong, Bin Li, Qiangqiang Zhang, Yudan Chi
{"title":"Dura immunity configures leptomeningeal metastasis immunosuppression for cerebrospinal fluid barrier invasion","authors":"Jiaxu Zhao, Rui Zeng, Xiaohui Li, Ying Lu, Zuoyun Wang, Haibao Peng, Hao Chen, Minjie Fu, Ye Zhang, Yang Huang, Wenhan Chen, Xin Wang, Yun Guan, Wei Han, Ruofan Huang, Chengjun Yao, Zhiyong Qin, Lingchao Chen, Liang Chen, Xue Feng, Hanting Yang, Patrícia M. R. Pereira, Xuemei Tong, Bin Li, Qiangqiang Zhang, Yudan Chi","doi":"10.1038/s43018-024-00858-2","DOIUrl":"10.1038/s43018-024-00858-2","url":null,"abstract":"The cerebrospinal fluid (CSF) border accommodates diverse immune cells that permit peripheral cell immunosurveillance. However, the intricate interactions between CSF immune cells and infiltrating cancer cells remain poorly understood. Here we use fate mapping, longitudinal time-lapse imaging and multiomics technologies to investigate the precise origin, cellular crosstalk and molecular landscape of macrophages that contribute to leptomeningeal metastasis (LM) progression. Mechanically, we find that dura-derived LM-associated macrophages (dLAMs) migrate into the CSF in a matrix metalloproteinase 14 (MMP14)-dependent manner. Furthermore, we identify that dLAMs critically require the presence of secreted phosphoprotein 1 (SPP1) in cancer cells for their recruitment, fostering an immunosuppressed microenvironment characterized by T cell exhaustion and inactivation. Conversely, inhibition of the SPP1–MMP14 axis can impede macrophages from bypassing the border barrier, prevent cancer cell growth and improve survival in LM mouse models. Our findings reveal an unexpectedly private source of innate immunity within the meningeal space, shed light on CSF barrier dysfunction dynamics and supply potential targets of clinical immunotherapy. Zhao et al. find that a macrophage subset migrates from the dura matter to reshape the cerebrospinal fluid microenvironment and promote metastasis and show that the secreted phosphoprotein 1–matrix metallopeptidase 14 axis can be targeted to inhibit this.","PeriodicalId":18885,"journal":{"name":"Nature cancer","volume":"5 12","pages":"1940-1961"},"PeriodicalIF":23.5,"publicationDate":"2024-12-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142870516","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Nature cancerPub Date : 2024-12-20DOI: 10.1038/s43018-024-00859-1
Michael Kilian, Francisco J. Quintana
{"title":"Immunosuppressive dura-derived macrophages in leptomeningeal metastasis","authors":"Michael Kilian, Francisco J. Quintana","doi":"10.1038/s43018-024-00859-1","DOIUrl":"10.1038/s43018-024-00859-1","url":null,"abstract":"Leptomeningeal metastases of solid tumors are associated with poor prognosis, limited treatment options and unclear immunosurveillance mechanisms. Dura-derived immunosuppressive macrophages are now shown to migrate to the cerebrospinal fluid, limiting anti-tumor CD8+ T cell responses in models of leptomeningeal metastasis.","PeriodicalId":18885,"journal":{"name":"Nature cancer","volume":"5 12","pages":"1791-1792"},"PeriodicalIF":23.5,"publicationDate":"2024-12-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142870527","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Nature cancerPub Date : 2024-12-17DOI: 10.1038/s43018-024-00856-4
Vincenzo Giacco
{"title":"Radioligand cancer therapy comes to the fore","authors":"Vincenzo Giacco","doi":"10.1038/s43018-024-00856-4","DOIUrl":"10.1038/s43018-024-00856-4","url":null,"abstract":"","PeriodicalId":18885,"journal":{"name":"Nature cancer","volume":"5 12","pages":"1782-1782"},"PeriodicalIF":23.5,"publicationDate":"2024-12-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142847097","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Nature cancerPub Date : 2024-12-17DOI: 10.1038/s43018-024-00857-3
Melanie Senior
{"title":"Beyond the hype of AI in cancer R&D","authors":"Melanie Senior","doi":"10.1038/s43018-024-00857-3","DOIUrl":"10.1038/s43018-024-00857-3","url":null,"abstract":"AI promises to create medicines faster, more cheaply, and with greater precision. Despite attracting big sums and splashy headlines, AI-powered biotechs have yet to get a product over the finish line. Where is AI’s greatest impact so far?","PeriodicalId":18885,"journal":{"name":"Nature cancer","volume":"5 12","pages":"1759-1761"},"PeriodicalIF":23.5,"publicationDate":"2024-12-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142847085","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Nature cancerPub Date : 2024-12-17DOI: 10.1038/s43018-024-00836-8
Tiffanie Chouleur
{"title":"Closing the gaps in cancer genomic disparities","authors":"Tiffanie Chouleur","doi":"10.1038/s43018-024-00836-8","DOIUrl":"10.1038/s43018-024-00836-8","url":null,"abstract":"","PeriodicalId":18885,"journal":{"name":"Nature cancer","volume":"5 12","pages":"1785-1785"},"PeriodicalIF":23.5,"publicationDate":"2024-12-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142847087","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Nature cancerPub Date : 2024-12-17DOI: 10.1038/s43018-024-00832-y
Ioanna Pavlaki
{"title":"Mini colons to study cancer ex vivo","authors":"Ioanna Pavlaki","doi":"10.1038/s43018-024-00832-y","DOIUrl":"10.1038/s43018-024-00832-y","url":null,"abstract":"","PeriodicalId":18885,"journal":{"name":"Nature cancer","volume":"5 12","pages":"1786-1786"},"PeriodicalIF":23.5,"publicationDate":"2024-12-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142847090","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Nature cancerPub Date : 2024-12-17DOI: 10.1038/s43018-024-00868-0
Cameron Walker, Michael Angelo
{"title":"Toward clinical applications of spatial-omics in cancer research","authors":"Cameron Walker, Michael Angelo","doi":"10.1038/s43018-024-00868-0","DOIUrl":"10.1038/s43018-024-00868-0","url":null,"abstract":"Spatial-omics tools, together with deep learning models, are revealing interactions between tumors and their environment, including immune cells, and are aiding human-like performance in histopathological analysis, with the potential to improve diagnostic accuracy and treatment choices.","PeriodicalId":18885,"journal":{"name":"Nature cancer","volume":"5 12","pages":"1771-1773"},"PeriodicalIF":23.5,"publicationDate":"2024-12-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142847101","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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