Nature cancer最新文献_第2页

Embracing the unexpected to make progress against cancer

IF 23.5 1区医学

Nature cancer Pub Date : 2025-01-30 DOI: 10.1038/s43018-024-00887-x

Alexia-Ileana Zaromytidou

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Thriving in diverse ecosystems

IF 23.5 1区医学

Nature cancer Pub Date : 2025-01-30 DOI: 10.1038/s43018-024-00888-w

Alexia-Ileana Zaromytidou

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Five years of Nature Cancer

IF 23.5 1区医学

Nature cancer Pub Date : 2025-01-30 DOI: 10.1038/s43018-025-00911-8

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Spatially resolved transcriptomics and graph-based deep learning improve accuracy of routine CNS tumor diagnostics.

IF 23.5 1区医学

Nature cancer Pub Date : 2025-01-29 DOI: 10.1038/s43018-024-00904-z

Michael Ritter, Christina Blume, Yiheng Tang, Areeba Patel, Bhuvic Patel, Natalie Berghaus, Jasim Kada Benotmane, Jan Kueckelhaus, Yahaya Yabo, Junyi Zhang, Elena Grabis, Giulia Villa, David Niklas Zimmer, Amir Khriesh, Philipp Sievers, Zaira Seferbekova, Felix Hinz, Vidhya M Ravi, Marcel Seiz-Rosenhagen, Miriam Ratliff, Christel Herold-Mende, Oliver Schnell, Juergen Beck, Wolfgang Wick, Andreas von Deimling, Moritz Gerstung, Dieter Henrik Heiland, Felix Sahm

{"title":"Spatially resolved transcriptomics and graph-based deep learning improve accuracy of routine CNS tumor diagnostics.","authors":"Michael Ritter, Christina Blume, Yiheng Tang, Areeba Patel, Bhuvic Patel, Natalie Berghaus, Jasim Kada Benotmane, Jan Kueckelhaus, Yahaya Yabo, Junyi Zhang, Elena Grabis, Giulia Villa, David Niklas Zimmer, Amir Khriesh, Philipp Sievers, Zaira Seferbekova, Felix Hinz, Vidhya M Ravi, Marcel Seiz-Rosenhagen, Miriam Ratliff, Christel Herold-Mende, Oliver Schnell, Juergen Beck, Wolfgang Wick, Andreas von Deimling, Moritz Gerstung, Dieter Henrik Heiland, Felix Sahm","doi":"10.1038/s43018-024-00904-z","DOIUrl":"https://doi.org/10.1038/s43018-024-00904-z","url":null,"abstract":"The diagnostic landscape of brain tumors integrates comprehensive molecular markers alongside traditional histopathological evaluation. DNA methylation and next-generation sequencing (NGS) have become a cornerstone in central nervous system (CNS) tumor classification. A limiting requirement for NGS and methylation profiling is sufficient DNA quality and quantity, which restrict its feasibility. Here we demonstrate NePSTA (neuropathology spatial transcriptomic analysis) for comprehensive morphological and molecular neuropathological diagnostics from single 5-µm tissue sections. NePSTA uses spatial transcriptomics with graph neural networks for automated histological and molecular evaluations. Trained and evaluated across 130 participants with CNS malignancies and healthy donors across four medical centers, NePSTA predicts tissue histology and methylation-based subclasses with high accuracy. We demonstrate the ability to reconstruct immunohistochemistry and genotype profiling on tissue with minimal requirements, inadequate for conventional molecular diagnostics, demonstrating the potential to enhance tumor subtype identification with implications for fast and precise diagnostic workup.","PeriodicalId":18885,"journal":{"name":"Nature cancer","volume":" ","pages":""},"PeriodicalIF":23.5,"publicationDate":"2025-01-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143066831","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Author Correction: Global loss of promoter-enhancer connectivity and rebalancing of gene expression during early colorectal cancer carcinogenesis.

IF 23.5 1区医学

Nature cancer Pub Date : 2025-01-26 DOI: 10.1038/s43018-025-00915-4

Yizhou Zhu, Hayan Lee, Shannon White, Annika K Weimer, Emma Monte, Aaron Horning, Stephanie A Nevins, Edward D Esplin, Kristina Paul, Gat Krieger, Zohar Shipony, Roxanne Chiu, Rozelle Laquindanum, Thomas V Karathanos, Melissa W Y Chua, Meredith Mills, Uri Ladabaum, Teri Longacre, Jeanne Shen, Ariel Jaimovich, Doron Lipson, Anshul Kundaje, William J Greenleaf, Christina Curtis, James M Ford, Michael P Snyder

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Inhibition of ERα signaling induces lineage plasticity in vivo.

IF 23.5 1区医学

Nature cancer Pub Date : 2025-01-24 DOI: 10.1038/s43018-024-00897-9

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TRIM28-dependent developmental heterogeneity determines cancer susceptibility through distinct epigenetic states. TRIM28依赖的发育异质性通过不同的表观遗传状态决定癌症易感性。

IF 23.5 1区医学

Nature cancer Pub Date : 2025-01-24 DOI: 10.1038/s43018-024-00900-3

Ilaria Panzeri, Luca Fagnocchi, Stefanos Apostle, Megan Tompkins, Emily Wolfrum, Zachary Madaj, Galen Hostetter, Yanqing Liu, Kristen Schaefer, Chih-Hsiang Yang, Alexis Bergsma, Anne Drougard, Erez Dror, Darrell P Chandler, Daniel Schramek, Timothy J Triche, John Andrew Pospisilik

{"title":"TRIM28-dependent developmental heterogeneity determines cancer susceptibility through distinct epigenetic states.","authors":"Ilaria Panzeri, Luca Fagnocchi, Stefanos Apostle, Megan Tompkins, Emily Wolfrum, Zachary Madaj, Galen Hostetter, Yanqing Liu, Kristen Schaefer, Chih-Hsiang Yang, Alexis Bergsma, Anne Drougard, Erez Dror, Darrell P Chandler, Daniel Schramek, Timothy J Triche, John Andrew Pospisilik","doi":"10.1038/s43018-024-00900-3","DOIUrl":"https://doi.org/10.1038/s43018-024-00900-3","url":null,"abstract":"Mutations in cancer risk genes increase susceptibility, but not all carriers develop cancer. Indeed, while DNA mutations are necessary drivers of cancer, only a small subset of mutated cells go on to cause the disease. To date, the mechanisms underlying individual cancer susceptibility remain unclear. Here, we took advantage of a unique mouse model of intrinsic developmental heterogeneity (Trim28+/D9) to investigate whether early-life epigenetic variation influences cancer susceptibility later in life. We found that heterozygosity of Trim28 is sufficient to generate two distinct early-life epigenetic states associated with differing cancer susceptibility. These developmentally primed states exhibit differential methylation patterns at typically silenced heterochromatin, detectable as early as 10 days of age. The differentially methylated loci are enriched for genes with known oncogenic potential, frequently mutated in human cancers and correlated with poor prognosis. This study provides genetic evidence that intrinsic developmental heterogeneity can prime individual, lifelong cancer susceptibility.","PeriodicalId":18885,"journal":{"name":"Nature cancer","volume":" ","pages":""},"PeriodicalIF":23.5,"publicationDate":"2025-01-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143040282","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Systemic IFN-I combined with topical TLR7/8 agonists promotes distant tumor suppression by c-Jun-dependent IL-12 expression in dendritic cells

IF 23.5 1区医学

Nature cancer Pub Date : 2025-01-23 DOI: 10.1038/s43018-024-00889-9

Martina Sanlorenzo, Philipp Novoszel, Igor Vujic, Tommaso Gastaldi, Martina Hammer, Ourania Fari, Cristiano De Sa Fernandes, Alina D. Landau, Bilge V. Göcen-Oguz, Martin Holcmann, Babak Monshi, Klemens Rappersberger, Agnes Csiszar, Maria Sibilia

{"title":"Systemic IFN-I combined with topical TLR7/8 agonists promotes distant tumor suppression by c-Jun-dependent IL-12 expression in dendritic cells","authors":"Martina Sanlorenzo, Philipp Novoszel, Igor Vujic, Tommaso Gastaldi, Martina Hammer, Ourania Fari, Cristiano De Sa Fernandes, Alina D. Landau, Bilge V. Göcen-Oguz, Martin Holcmann, Babak Monshi, Klemens Rappersberger, Agnes Csiszar, Maria Sibilia","doi":"10.1038/s43018-024-00889-9","DOIUrl":"10.1038/s43018-024-00889-9","url":null,"abstract":"Dendritic cell (DC) activation by pattern recognition receptors like Toll-like-receptors (TLRs) is crucial for cancer immunotherapies. Here, we demonstrate the effectiveness of the TLR7/8 agonist imiquimod (IMQ) in treating both local tumors and distant metastases. Administered orally, IMQ activates plasmacytoid DCs (pDCs) to produce systemic type I interferons (IFN-I) required for TLR7/8 upregulation in DCs and macrophages, sensitizing them to topical IMQ treatment, which is essential for therapeutic efficacy. The mechanism involves c-Jun/AP-1 mediating TLR7/8 signaling in IFN-I-primed DCs, upregulating the pDC-recruiting chemokine CCL2 and the anti-angiogenic cytokine interleukin-12, which suppresses VEGF-A production leading to tumor necrosis and regression. Combining topical and systemic IMQ or IFN-I generates a CD8+ T cell-dependent response at metastatic sites, reinforced by PD-1 blockade, leading to long-lasting memory. Analysis of cohorts of patients with melanoma demonstrates DC-specific TLR7/8 upregulation by IFN-I, supporting the translational potential of combining systemic IFN-I and topical IMQ to improve immunotherapy of topically accessible tumors. Sanlorenzo et al. propose a strategy to boost immunotherapy by combining topically applied TLR7/8 agonists with systemic interferon-I, sensitizing dendritic cells to produce IL-12 for tumor clearance and an adaptive immune response at metastatic sites.","PeriodicalId":18885,"journal":{"name":"Nature cancer","volume":"6 1","pages":"175-193"},"PeriodicalIF":23.5,"publicationDate":"2025-01-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11779648/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143029174","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Targeting BRCA1-deficient PARP inhibitor-resistant cells with nickases reveals nick resection as a cancer vulnerability. 用切口酶靶向brca1缺陷PARP抑制剂耐药细胞，揭示了切口切除是一种癌症易感性。

IF 23.5 1区医学

Nature cancer Pub Date : 2025-01-21 DOI: 10.1038/s43018-024-00902-1

Jenna M Whalen, Jillian Earley, Christi Wisniewski, Arthur M Mercurio, Sharon B Cantor

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Refining biomarker design in light of cancer evolution 根据癌症进化改进生物标志物设计。

IF 23.5 1区医学

Nature cancer Pub Date : 2025-01-20 DOI: 10.1038/s43018-024-00884-0

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