Nature cancer最新文献_第2页

Gut microbiota-derived formate mediates the antitumor benefits of exercise 肠道微生物源甲酸介导运动的抗肿瘤作用。

IF 28.5 1区医学

Nature cancer Pub Date : 2025-09-10 DOI: 10.1038/s43018-025-01049-3

M. Teresa Villanueva

引用次数: 0

Gut check for CAR T success CAR - T成功的内脏检查。

IF 28.5 1区医学

Nature cancer Pub Date : 2025-09-10 DOI: 10.1038/s43018-025-01051-9

Gabrielle Brewer

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A sphingolipid-derived paclitaxel nanovesicle for improved cancer therapy. 鞘脂衍生的紫杉醇纳米囊泡用于改善癌症治疗。

IF 28.5 1区医学

Nature cancer Pub Date : 2025-09-04 DOI: 10.1038/s43018-025-01030-0

引用次数: 0

Artificial intelligence for prostate cancer diagnostics. 前列腺癌诊断的人工智能。

IF 28.5 1区医学

Nature cancer Pub Date : 2025-09-02 DOI: 10.1038/s43018-025-01034-w

Antti S Rannikko

引用次数: 0

An MRI-pathology foundation model for noninvasive diagnosis and grading of prostate cancer. 前列腺癌无创诊断和分级的mri病理基础模型。

IF 28.5 1区医学

Nature cancer Pub Date : 2025-09-02 DOI: 10.1038/s43018-025-01041-x

Lizhi Shao, Chao Liang, Ye Yan, Haibin Zhu, Xiaoming Jiang, Meiling Bao, Pan Zang, Xiazi Huang, Hongyu Zhou, Pei Nie, Liang Wang, Jie Li, Shudong Zhang, Shancheng Ren

{"title":"An MRI-pathology foundation model for noninvasive diagnosis and grading of prostate cancer.","authors":"Lizhi Shao, Chao Liang, Ye Yan, Haibin Zhu, Xiaoming Jiang, Meiling Bao, Pan Zang, Xiazi Huang, Hongyu Zhou, Pei Nie, Liang Wang, Jie Li, Shudong Zhang, Shancheng Ren","doi":"10.1038/s43018-025-01041-x","DOIUrl":"https://doi.org/10.1038/s43018-025-01041-x","url":null,"abstract":"Prostate cancer is a leading health concern for men, yet current clinical assessments of tumor aggressiveness rely on invasive procedures that often lead to inconsistencies. There remains a critical need for accurate, noninvasive diagnosis and grading methods. Here we developed a foundation model trained on multiparametric magnetic resonance imaging (MRI) and paired pathology data for noninvasive diagnosis and grading of prostate cancer. Our model, MRI-based Predicted Transformer for Prostate Cancer (MRI-PTPCa), was trained under contrastive learning on nearly 1.3 million image-pathology pairs from over 5,500 patients in discovery, modeling, external and prospective cohorts. During real-world testing, prediction of MRI-PTPCa demonstrated consistency with pathology and superior performance (area under the curve above 0.978; grading accuracy 89.1%) compared with clinical measures and other prediction models. This work introduces a scalable, noninvasive approach to prostate cancer diagnosis and grading, offering a robust tool to support clinical decision-making while reducing reliance on biopsies.","PeriodicalId":18885,"journal":{"name":"Nature cancer","volume":" ","pages":""},"PeriodicalIF":28.5,"publicationDate":"2025-09-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144961810","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Epigenomics and CRISPRi reveal cis-regulatory elements in colorectal cancer. 表观基因组学和CRISPRi揭示结直肠癌的顺式调控元件。

IF 28.5 1区医学

Nature cancer Pub Date : 2025-08-29 DOI: 10.1038/s43018-025-01032-y

引用次数: 0

Cancer-derived mitochondria fuel fibroblasts to become pro-tumorigenic. 癌症来源的线粒体为成纤维细胞提供燃料，使其成为致瘤原。

IF 28.5 1区医学

Nature cancer Pub Date : 2025-08-28 DOI: 10.1038/s43018-025-01005-1

Daniel Delitto, Michael T Longaker

引用次数: 0

MIRO2-mediated mitochondrial transfer from cancer cells induces cancer-associated fibroblast differentiation. 来自癌细胞的miro2介导的线粒体转移诱导癌症相关成纤维细胞分化。

IF 28.5 1区医学

Nature cancer Pub Date : 2025-08-28 DOI: 10.1038/s43018-025-01038-6

Michael Cangkrama, Huan Liu, Xiaoyu Wu, Josephine Yates, James Whipman, Christoph G Gäbelein, Mai Matsushita, Luca Ferrarese, Sibilla Sander, Francesc Castro-Giner, Simran Asawa, Magdalena K Sznurkowska, Manfred Kopf, Jörn Dengjel, Valentina Boeva, Nicola Aceto, Julia A Vorholt, Sabine Werner

{"title":"MIRO2-mediated mitochondrial transfer from cancer cells induces cancer-associated fibroblast differentiation.","authors":"Michael Cangkrama, Huan Liu, Xiaoyu Wu, Josephine Yates, James Whipman, Christoph G Gäbelein, Mai Matsushita, Luca Ferrarese, Sibilla Sander, Francesc Castro-Giner, Simran Asawa, Magdalena K Sznurkowska, Manfred Kopf, Jörn Dengjel, Valentina Boeva, Nicola Aceto, Julia A Vorholt, Sabine Werner","doi":"10.1038/s43018-025-01038-6","DOIUrl":"https://doi.org/10.1038/s43018-025-01038-6","url":null,"abstract":"Cancer-associated fibroblasts (CAFs) are key components of the tumor microenvironment that commonly support cancer development and progression. Here we show that different cancer cells transfer mitochondria to fibroblasts in cocultures and xenograft tumors, thereby inducing protumorigenic CAF features. Transplantation of functional mitochondria from cancer cells induces metabolic alterations in fibroblasts, expression of CAF markers and release of a protumorigenic secretome and matrisome. These features promote tumor formation in preclinical mouse models. Mechanistically, the mitochondrial transfer requires the mitochondrial trafficking protein MIRO2. Its depletion in cancer cells suppresses mitochondrial transfer and inhibits CAF differentiation and tumor growth. The clinical relevance of these findings is reflected by the overexpression of MIRO2 in tumor cells at the leading edge of epithelial skin cancers. These results identify mitochondrial transfer from cancer cells to fibroblasts as a driver of tumorigenesis and provide a rationale for targeting MIRO2 and mitochondrial transfer in different malignancies.","PeriodicalId":18885,"journal":{"name":"Nature cancer","volume":" ","pages":""},"PeriodicalIF":28.5,"publicationDate":"2025-08-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144961865","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Telescopes, telomeres and turning points 望远镜、端粒和转折点。

IF 28.5 1区医学

Nature cancer Pub Date : 2025-08-27 DOI: 10.1038/s43018-025-01024-y

Ronald A. DePinho

引用次数: 0

Spatiotemporal analyses of the pan-cancer single-cell landscape reveal widespread profibrotic ecotypes associated with tumor immunity. 泛癌症单细胞景观的时空分析揭示了与肿瘤免疫相关的广泛的纤维化生态型。

IF 28.5 1区医学

Nature cancer Pub Date : 2025-08-25 DOI: 10.1038/s43018-025-01039-5

Ya Han, Lele Zhang, Dongqing Sun, Guangxu Cao, Yuting Wang, Jiali Yue, Junjie Hu, Zhonghua Dong, Fang Li, Taiwen Li, Peng Zhang, Qiu Wu, Chenfei Wang

{"title":"Spatiotemporal analyses of the pan-cancer single-cell landscape reveal widespread profibrotic ecotypes associated with tumor immunity.","authors":"Ya Han, Lele Zhang, Dongqing Sun, Guangxu Cao, Yuting Wang, Jiali Yue, Junjie Hu, Zhonghua Dong, Fang Li, Taiwen Li, Peng Zhang, Qiu Wu, Chenfei Wang","doi":"10.1038/s43018-025-01039-5","DOIUrl":"https://doi.org/10.1038/s43018-025-01039-5","url":null,"abstract":"The tumor microenvironment evolves during tumor development and influences the cells in the microenvironment to orchestrate a supportive environment for tumor growth. Here we collected 4,483,367 cells across 36 cancer types and constructed a pan-cancer resource named TabulaTIME. Our integrated analyses reveal that CTHRC1 is a hallmark of extracellular matrix-related cancer-associated fibroblasts (CAFs) that are enriched in different cancer types. Spatiotemporal analyses further indicated that CTHRC1+ CAFs are located at the leading edge between the malignant and normal regions, potentially preventing immune infiltration. Moreover, we identified that SLPI+ macrophages exhibit profibrotic-associated phenotypes and colocalize with CTHRC1+ CAFs to form unique spatial ecotypes. Finally, we demonstrated that TabulaTIME can be used to analyze tumor ecotype composition and can serve as a reference for cell-type annotation. This work establishes a comprehensive single-cell landscape of the heterogenous TME and offers a potential therapeutic strategy for targeting the profibrotic ecotype in cancer treatment.","PeriodicalId":18885,"journal":{"name":"Nature cancer","volume":" ","pages":""},"PeriodicalIF":28.5,"publicationDate":"2025-08-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144961818","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0