Prospects for ferroptosis therapies in cancer

IF 28.5 1区医学 Q1 ONCOLOGY

Nature cancer Pub Date : 2025-08-18 DOI:10.1038/s43018-025-01037-7

Jessalyn M. Ubellacker, Scott J. Dixon

引用次数: 0

Abstract

Ferroptosis is a nonapoptotic form of cell death characterized by lethal membrane lipid peroxidation. This mechanism was first characterized in cancer cells well over a decade ago, and there is much enthusiasm for the concept that certain cancers may be treated by inducing ferroptosis. However, therapies that engage ferroptosis have yet to enter clinical testing. In this Review, we highlight the gap between our rapidly expanding knowledge of the ferroptosis mechanism and its translation into cancer therapies. We discuss the known challenges that may be slowing ferroptosis therapies from reaching the clinic. Ubellacker and Dixon summarize the latest discoveries on ferroptosis in cancer, covering the molecular and cellular pathways underlying sensitivity and resistance to this type of cell death, as well as potential translational applications in cancer therapeutics.

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铁下垂治疗癌症的前景。

铁下垂是一种以致死性膜脂过氧化为特征的非凋亡形式的细胞死亡。这种机制早在十多年前就在癌细胞中首次被发现，人们对某些癌症可能通过诱导铁下垂来治疗的概念非常感兴趣。然而，治疗铁下垂尚未进入临床试验。在这篇综述中，我们强调了我们快速扩展的铁下垂机制知识与其转化为癌症治疗之间的差距。我们讨论了已知的挑战，可能会减慢铁下垂疗法从达到临床。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Nature cancer Medicine-Oncology

CiteScore

31.10

自引率

1.80%

发文量

129

期刊介绍： Cancer is a devastating disease responsible for millions of deaths worldwide. However, many of these deaths could be prevented with improved prevention and treatment strategies. To achieve this, it is crucial to focus on accurate diagnosis, effective treatment methods, and understanding the socioeconomic factors that influence cancer rates. Nature Cancer aims to serve as a unique platform for sharing the latest advancements in cancer research across various scientific fields, encompassing life sciences, physical sciences, applied sciences, and social sciences. The journal is particularly interested in fundamental research that enhances our understanding of tumor development and progression, as well as research that translates this knowledge into clinical applications through innovative diagnostic and therapeutic approaches. Additionally, Nature Cancer welcomes clinical studies that inform cancer diagnosis, treatment, and prevention, along with contributions exploring the societal impact of cancer on a global scale. In addition to publishing original research, Nature Cancer will feature Comments, Reviews, News & Views, Features, and Correspondence that hold significant value for the diverse field of cancer research.