Nanotechnology, Science and Applications最新文献

{"title":"Loading Amlodipine on Diamond Nanoparticles: A Novel Drug Delivery System.","authors":"Shawqi H Alawdi,&nbsp;Housam Eidi,&nbsp;Marwa M Safar,&nbsp;Mosaad A Abdel-Wahhab","doi":"10.2147/NSA.S232517","DOIUrl":"https://doi.org/10.2147/NSA.S232517","url":null,"abstract":"<p><strong>Background: </strong>Diamond nanoparticles (Nanodiamond) are biocompatible drug delivery platforms with outstanding surface properties. Their passage into the brain has been confirmed previously. Thus, nanodiamond could provide a drug delivery system to shuttle several drugs through the blood-brain barrier (BBB) which represents a real challenge for the effective delivery of several drugs into the brain. Amlodipine is a calcium channel blocker that cannot pass through BBB and may elicit neuroprotective effects to reverse calcium-induced excitotoxicity and mitochondrial dysfunction that underlie several neurologic disorders including Alzheimer's disease and stroke.</p><p><strong>Aim: </strong>The study aimed to investigate the loading of amlodipine on nanodiamond particles.</p><p><strong>Methods: </strong>Nanodiamond particles were oxidized in a strong oxidizing acidic mixture of sulfuric and nitric acids. Adsorption of amlodipine on nanodiamond particles was achieved in alkaline pH using various concentrations of sodium hydroxide. The loaded amlodipine was determined by high-performance liquid chromatography and confirmed by Fourier transform infrared (FTIR) spectroscopy and transmission electron microscopy.</p><p><strong>Results: </strong>The highest percentage (41%) of loaded amlodipine onto nanodiamond particles was achieved in alkaline medium using 2 mM NaOH at a corresponding pH of 8.5. Also, characteristic FTIR bands of amlodipine and nanodiamond were shown obviously in the nanodiamond-amlodipine conjugates. Moreover, the successful loading of amlodipine on diamond nanoparticles was confirmed by transmission electron microscopy.</p><p><strong>Conclusion: </strong>The present study demonstrates the successful loading of amlodipine onto nanodiamond particles. These findings offer a potential for applying diamond nanoparticles as a drug delivery system to shuttle amlodipine into the brain and open the door to deliver other similar drugs into the brain.</p>","PeriodicalId":18881,"journal":{"name":"Nanotechnology, Science and Applications","volume":"12 ","pages":"47-53"},"PeriodicalIF":4.9,"publicationDate":"2019-12-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.2147/NSA.S232517","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"37677899","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Static DNA Nanostructures For Cancer Theranostics: Recent Progress In Design And Applications.","authors":"Rana Jahanban-Esfahlan,&nbsp;Khaled Seidi,&nbsp;Ali Jahanban-Esfahlan,&nbsp;Mehdi Jaymand,&nbsp;Effat Alizadeh,&nbsp;Hasan Majdi,&nbsp;Reza Najjar,&nbsp;Tahereh Javaheri,&nbsp;Peyman Zare","doi":"10.2147/NSA.S227193","DOIUrl":"https://doi.org/10.2147/NSA.S227193","url":null,"abstract":"<p><p>Among the various nano/biomaterials used in cancer treatment, the beauty and benefits of DNA nanocomposites are outstanding. The specificity and programmability of the base pairing of DNA strands, together with their ability to conjugate with different types of functionalities have realized unsurpassed potential for the production of two- and three-dimensional nano-sized structures in any shape, size, surface chemistry and functionality. This review aims to provide an insight into the diversity of static DNA nanodevices, including DNA origami, DNA polyhedra, DNA origami arrays and bioreactors, DNA nanoswitch, DNA nanoflower, hydrogel and dendrimer as young but promising platforms for cancer theranostics. The utility and potential of the individual formats in biomedical science and especially in cancer therapy will be discussed.</p>","PeriodicalId":18881,"journal":{"name":"Nanotechnology, Science and Applications","volume":"12 ","pages":"25-46"},"PeriodicalIF":4.9,"publicationDate":"2019-10-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.2147/NSA.S227193","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41205630","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Magnetically controlled protein nanocontainers as a drug depot for the hemostatic agent.","authors":"Artur Prilepskii,&nbsp;Alexandra Schekina,&nbsp;Vladimir Vinogradov","doi":"10.2147/NSA.S204621","DOIUrl":"https://doi.org/10.2147/NSA.S204621","url":null,"abstract":"<p><strong>Purpose: </strong>Currently, there is a number of successfully implemented local hemostatic agents for external bleedings in forms of wound dressings and other topical materials. However, little has been done in the field of intravenous hemostatic agents. Here, we propose a new procedure to fabricate biocompatible protein nanocontainers (NCs) for intravenous injection allowing magneto-controllable delivery and short-term release of the hemostatic agent ε-aminocaproic acid (EACA).</p><p><strong>Methods: </strong>The nanocontainers were synthesized by the desolvation method from bovine serum albumin (BSA) using methanol without any further crosslinking. Polyethylene glycol (PEG) was used both as a stabilization agent and for size control. Characterization of nanocontainers was performed by the transmission and scanning electron microscopy, dynamic light scattering, X-ray diffraction, and FTIR spectroscopy. Cytotoxicity was estimated using MTT assay. The dopant release from nanocontainers was measured spectrophotometrically using rhodamine B as a model molecule. The specific hemostatic activity was assessed by analyzing clot lysis and formation curve (CloFAL). Moreover, the ability for magneto targeting was estimated using the original flow setup made of a syringe pump and silicon contours.</p><p><strong>Results: </strong>Fabricated nanocontainers had an average size of 186±24 nm and were constructed from building blocks-nanoparticles with average size ranged from 10 to 20 nm. PEG shell was also observed around nanocontainers with thickness 5-10 nm. NCs were proved to be completely non-cytotoxic even at concentrations up to 8 mg BSA/mL. Uptake capacity was near 36% while release within the first day was 17%. The analysis of the CloFAL curve showed the ability of NCs to inhibit the clot lysis successfully, and the ability of magneto targeting was confirmed under flow conditions.</p><p><strong>Conclusion: </strong>The ability of synthesized NCs to deliver and release the therapeutic drug, as well as to accumulate at the desired site under the action of the magnetic field was proved experimentally.</p>","PeriodicalId":18881,"journal":{"name":"Nanotechnology, Science and Applications","volume":"12 ","pages":"11-23"},"PeriodicalIF":4.9,"publicationDate":"2019-07-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.2147/NSA.S204621","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41205629","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Thermodynamics and kinetic analysis of carbon nanofibers as nanozymes.","authors":"Maziar Bahreini,&nbsp;Monireh Movahedi,&nbsp;Maryam Peyvandi,&nbsp;Fereshteh Nematollahi,&nbsp;Hessam Sepasi Tehrani","doi":"10.2147/NSA.S208310","DOIUrl":"https://doi.org/10.2147/NSA.S208310","url":null,"abstract":"<p><strong>Purpose: </strong>Evaluation of structural features, thermodynamics and kinetic properties of carbon nanofibers (CNFs) as artificial nanoscale enzymes (nanozyme).</p><p><strong>Methods: </strong>Synthesis of CNFs was done using chemical vapor deposition, and transmission electron microscopy (TEM), field emission scanning electron microscopy (FE-SEM) and energy-dispersive x-ray spectroscopy (EDX) were used to provide information on the morphology, elemental monitoring and impurity assay of the CNFs. The thermal features of the CNFs were evaluated using differential thermal analysis (DTA), differential scanning calorimetry (DSC), thermogravimetric analysis (TGA) derivative and TGA. The calculated thermo-physical parameters were melting temperature (<i>Tm</i>), weight loss maximum temperature (<i>T_max</i> ) and enthalpy of fusion (Δ<i>H_fusion</i> ). Catalytic activity was assayed by a 4-aminoantypyrine (4-AAP)-H₂O₂ coupled colorimetric system by UV-visible spectroscopy.</p><p><strong>Results: </strong>FE-SEM and TEM analysis demonstrated parallel graphitic layers and uniformity of atomic orientation and morphology. The EDX spectra approved carbon element as major signal and presence of partial Ti as impurities of CNFs during CVD process. The DTA thermogram showed the endothermic process had a maximum temperature of 82.27°C at -15.48 mV and that thermal decomposition occurred at about 200°C. The TGA-differential gravimetric analysis thermogram showed that <i>T_max</i> was 700°C. The DSC heat flow curve showed a melting temperature (Tm) of 254.52°C, Δ<i>H_fusion</i> of 3.84 J^.g^-1, area under the curve of 58.58 mJ and <i>T_e</i> (onset) and <i>T_f</i> (end set) temperatures of 246.60°C and 285.67°C, respectively. The peroxidase activity of the CNFs obeyed the Michaelis-Menten equation with a double-reciprocal curve and the calculated <i>K_m, K_cat</i> and <i>V_max</i> kinetic parameters.</p><p><strong>Conclusion: </strong>CNFs as peroxidase nanozymes are intrinsically strong and stable nanocatalysts under difficult thermal conditions. The peroxidase activity was demonstrated, making these CNFs candidates for analytical tools under extreme conditions.</p>","PeriodicalId":18881,"journal":{"name":"Nanotechnology, Science and Applications","volume":"12 ","pages":"3-10"},"PeriodicalIF":4.9,"publicationDate":"2019-07-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.2147/NSA.S208310","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41205631","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Synthesis, characterization, and in vitro evaluation of novel polymer-coated magnetic nanoparticles for controlled delivery of doxorubicin [Retraction].","authors":"","doi":"10.2147/NSA.S207535","DOIUrl":"https://doi.org/10.2147/NSA.S207535","url":null,"abstract":"<p><p>[This retracts the article DOI: 10.2147/NSA.S24328.].</p>","PeriodicalId":18881,"journal":{"name":"Nanotechnology, Science and Applications","volume":"12 ","pages":"1-2"},"PeriodicalIF":4.9,"publicationDate":"2019-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.2147/NSA.S207535","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"37269358","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Fabrication of Polyaniline-Zr(IV) Molybdophosphate as a Nanocomposite and its Potential Applications","authors":"Bushra R, K. M.A, Sakdapipanich J.T","doi":"10.33425/2639-9466.1008","DOIUrl":"https://doi.org/10.33425/2639-9466.1008","url":null,"abstract":"Electrically conductive composite material PANIZr(IV) molybdophosphate (PZMP) was synthesized, via treatment of Zr(IV) molybdophosphate with PANI(polyaniline) gel. The membrane of this material is fabricated for detection of mercury in waste samples. By using 4-in-line-probe the conducting behaviour of the material was determined, and it was found that conductivity of the nanocomposite lies in the range of semiconductors. The composite showed improved electrochemical properties and outstanding biological activities.","PeriodicalId":18881,"journal":{"name":"Nanotechnology, Science and Applications","volume":"417 1","pages":""},"PeriodicalIF":4.9,"publicationDate":"2018-12-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"77764530","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"FEM Analysis for Burring Process of Large Diameter SUS304 Tube","authors":"J. Ichikawa, S. Nishida, Yuta Kashitani, Kentaro Tsunoda, Yuto Horigome, Naoki Ikeda, Y. Sato","doi":"10.33425/2639-9466.1011","DOIUrl":"https://doi.org/10.33425/2639-9466.1011","url":null,"abstract":"T paper describes a finite element method (FEM) analysis for cold burring process of large diameter SUS304 pipe. The large diameter pipes such as 216.3 mm are used for a plant as a flow channel of gas and liquid. A burring process of pipe is generally for forming the branch. Burring molding is one of the typical molding techniques for branch pipes. The burring process is achieved by drawing of die from prepared hole. And the branch pipes are generally joined by welding. However this process has some problem. First, the burring process is depending on the forming limit of pipe. Second, the wall thickness and strain distribution of formed branch edge is unequal. These problem is caused the pre-hole shape. It generally has difficulty to determine the optimum pre-hole shape. Many try and error is needed. In this study, we proposed that the method of estimation for optimum pre-hole shape of mother pipe by finite element method analysis. The nominal diameter of mother pipe is 200A. And the target nominal diameter of branch pipe is 100A. The diameter is 114.3 mm, and the wall thickness is 3.0 mm. And target burring wall height is 10 mm with uniformly wall height around the edge. The height 10 mm means that is not needed the machining after burring process and is easy to weld to join the branch pipe to mother pipe. Initial pre-hole shape of analysis model is simple circle. After FEM analysis, the height of burring position was measured. Then the diameters of longitudinal direction and circumferential direction was adjusted. After optimum diameter of both direction diameter was determined, the diameter of 45 °direction was analyzed by using point tracking function to estimate of initial optimum diameter. Eventually, the burring formed shape had an uniform 10 mm height. It was clarified that the method of estimation for optimum pre-hole was effective. Junshi Ichikawa et al., Res. Rev. J Mat. Sci. 2018, Volume 6 DOI: 10.4172/2321-6212-C3-020","PeriodicalId":18881,"journal":{"name":"Nanotechnology, Science and Applications","volume":"16 1","pages":""},"PeriodicalIF":4.9,"publicationDate":"2018-12-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"85204853","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Effects of Microalloying Elements and Temperaging Treatments Parameters on Nb-V Containing Cast Microalloyed Steels","authors":"E. F., R. J., Najafidejdehmonfared H","doi":"10.33425/2639-9466.1009","DOIUrl":"https://doi.org/10.33425/2639-9466.1009","url":null,"abstract":"Electrically conductive composite material PANIZr(IV) molybdophosphate (PZMP) was synthesized, via treatment of Zr(IV) molybdophosphate with PANI (polyaniline) gel. The membrane of this material is fabricated for detection of mercury in waste samples. By using 4-in-line-probe the conducting behaviour of the material was determined, and it was found that conductivity of the nanocomposite lies in the range of semiconductors. The composite showed In this study, base composition without alloying elements and three microalloyed steels containing 0.08% wt V, 0.06% wt Nb and 0.06% wt Nb-0.1% wt V in induction furnace, in controlled condition, were casted. Temperaging were carried out on all of specimens for precipitation strengthening. For studying the influence of temperaging time and temperature, specimens with different chemical compositions were temperaged at 400,500,600 and 700 °C for 1,3 and 5 h. All of specimens in as-cast condition were studied using optical microscope and hardness tester. Results showed that as-cast specimens having ferrito-pearlitic microstructures. Nb-bearing specimens shows acicular microstructures. The heat treated samples were studied using Electron Microscope Analysis and hardness tester. Studying of mechanical properties of heat treated specimens, showed that because of precipitation strengthening, hardness of samples increased. By increasing of temperaging temperature in a constant time, hardness has an optimum value. Material To study the effects of microalloying additions and cooling rate on the microstructural and mechanical properties, three heats were produced in the form of 8Cm ×8Cm ×20Cm and 8Cm ×3Cm ×20Cm blocks. The chemical composition of these heats is shown in Table 1. Samle C Mn Si P S V Nb N Base 0.15 1.5 0.3 0.01 0.015 0.01 V 0.15 1.5 0.3 0.01 0.015 0.1 0.01 Nb 0.15 1.5 0.3 0.009 0.011 0.04 0.01 Nb-V 0.15 1.5 0.3 0.009 0.012 0.1 0.04 0.01 Table 1: Chemical compositions of alloys studied (weight %). The alloy designations in Table 1 show the main alloying elements in the heats. The base composition for all heats is 0.15 wt% carbon and 1.5 wt% Mn. Ferroniobium was added to some heats to raise the Nb level to 0.04 wt%. Furthermore, sulfur plus phosphorus levels ranged from 0.02 to 0.035 for all heats. Experimental results To assess the effects of microalloying additions on the mechanical properties, tensile, hardness and Charpy impact tests were conducted for each composition. In order to avoid scattering, three samples were prepared for each test. Optical microscopy and scanning electron microscopy were used for justifying the variation in the mechanical properties. Samples of each heat were optically examined at magnifications ranging from 100 to 1000 times in order to observe major phases and their distributions. Moreover, pearlite volume fraction was determined quantitatively using an image analyzer. Scanning electron microscopy was used for more detailed study of pearlite. Optical microscopy The optical","PeriodicalId":18881,"journal":{"name":"Nanotechnology, Science and Applications","volume":"5 1","pages":""},"PeriodicalIF":4.9,"publicationDate":"2018-12-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"89668602","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Horizontal Twin Roll Strip Casting of Aluminum Alloy A7075","authors":"Yuta Kashitani, S. Nishida, J. Ichikawa, Kentaro Tsunoda, Yuto Horigome, Y. Nitta, Hideto Harada","doi":"10.33425/2639-9466.1014","DOIUrl":"https://doi.org/10.33425/2639-9466.1014","url":null,"abstract":"Twin roll strip casting of aluminum alloy A7075 using commercial scale machine was operated. Twin roll casting process is able to produce a strip from molten metal directly. Thus this process has a possibility to reduce total cost of sheet making comparing to conventional rolling process. Strip casting process has some disadvantages. Casting speed depends on the material properties. It is difficult to determine the casting conditions. Aluminum alloy A7075 has high tensile strength, and it is known as a material for aerospace application. The sheet is manufactured in small quantities comparing to the other sheet aluminum alloy. It is supposed that the demand of high tensile strength aluminum sheet such as A7075 is going to increase for weight saving of structural material. The aims of this study are to investigate the effect of roll speed on the strip. Strip could not be produced continuously at roll speed of 10 m/min, so the load limit of this experimental apparatus was exceeded. However, a good strip without cracks was produced. Continuous strip was produced at a roll speed of 20 m/min. The strip was consisted of a mat part and a metallic luster part. However, cracks were observed in the white mat part of the board. Continuous strip was produced at a roll speed of 30 m/min. However, rolling cracks were observed at the edges of the strip. It is necessary to control the solidification distance by installing the nozzle.","PeriodicalId":18881,"journal":{"name":"Nanotechnology, Science and Applications","volume":"3 1","pages":""},"PeriodicalIF":4.9,"publicationDate":"2018-12-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"87429401","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cold Plastic Forming of ABS Plastic Pipe","authors":"Kentaro Tsunoda, S. Nishida, J. Ichikawa, Yuta Kashitani, Yuto Horigome, Naoki Ikeda, Hideto Harada, Nobuyuki Kamei","doi":"10.33425/2639-9466.1012","DOIUrl":"https://doi.org/10.33425/2639-9466.1012","url":null,"abstract":"This paper describes about cold plastic forming of ABS plastic pipe. Experiment and Finite element method (FEM) analysis of pipe expansion process were operated. The application of ABS plastic pipe for air conditioner is under consideration instead of metal pipe in Japan because of weight saving of air conditioner for lowering the gravity point against earthquake. The parts of ABS plastic pipe is generally produced by injection molding. The processes need the cooling time, and it takes much time. In addition, expensive mold die is needed for each application. Thus, cold plastic forming of ABS plastic pipe was proposed. The cold plastic forming of ABS plastic pipe chosen for this study is hardly studied by other authors. Product ability of cold plastic forming is higher than the injection molding or hot working. And the punch and die shape is simple comparing to these process. In this study, pipe expansion process was operated. The ABS plastic pipe has a 10 mm diameter and 8mm inner diameter and 1 mm thickness. At first, true stress and true strain curves at any strain rate were measured by ring compression test. Obtained flow stresses was used to FEM analysis. Experimental device for pipe expansion process was made by Dip Inc.. Objective inner diameter was 10 mm. FEM analysis was operated to clarify the deformation behavior such as load-stroke diagram. It was possible to produce the expanded ABS pipe. The whitening of worked pipe and strain recovery was observed. Analysis result was indicated the good agreement comparing to experimental result in load-stroke diagram.","PeriodicalId":18881,"journal":{"name":"Nanotechnology, Science and Applications","volume":"106 1","pages":""},"PeriodicalIF":4.9,"publicationDate":"2018-12-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"76077119","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}