Nanotechnology, Science and Applications最新文献

{"title":"Green Nanoparticles in Precision Agriculture: A Critical Review of Smart Crop Management, Nano-Enabled Delivery Systems, and Sustainable Farming.","authors":"Abisha Meji Marshal Williams, Milon Selvam Dennison, Sarad Pawar Naik Bukke, Bosco Christin Maria Arputham Ashwin","doi":"10.2147/NSA.S632332","DOIUrl":"10.2147/NSA.S632332","url":null,"abstract":"<p><p>Sustainable agricultural production requires approaches that improve resource-use efficiency while limiting environmental burdens. This critical review examines green-synthesized Nanoparticles (NPs) in precision agriculture, covering sustainable synthesis, smart crop management, nano-enabled delivery systems, nano-biosensors, plant-nanoparticle interactions, environmental risks, circular agriculture, and digital technologies. The NPs derived from Plant, microbial, biomolecule, and waste shows potential for targeted nutrient delivery, crop protection, stress management, and improved monitoring. However, reported performance varies with NP size, surface properties, concentration, formulation, crop type, soil, and environmental conditions. The review therefore critically considers both benefits and risks, including phytotoxicity, effects on beneficial microorganisms, persistence, bioaccumulation, and long-term ecosystem impacts. Waste-derived NPs and circular nanomanufacturing offer opportunities for resource recovery and agricultural waste valorization, but their scalability and economic feasibility remain uncertain. The integration with Artificial Intelligence (AI), Internet of Things (IoTs), Unmanned Aerial Vehicles (UAVs), remote sensing, and smart decision-support systems may improve site-specific management. The review also examines technology readiness, commercialization pathways, manufacturing consistency, cost, and regulatory requirements. The green NPs shows promise for sustainable precision agriculture, but wider adoption requires stronger field validation, standardized characterization, environmental risk assessment, reproducible manufacturing, economic evaluation, and responsible regulatory development.</p>","PeriodicalId":18881,"journal":{"name":"Nanotechnology, Science and Applications","volume":"19 ","pages":"632332"},"PeriodicalIF":7.6,"publicationDate":"2026-10-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13679550/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149228347","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Green Nanoarchitectonics of Adaptive Electronic Nanomaterials for Biocompatible Biointerfaces and Improved Human Health.","authors":"Vrinda Gupta, Md Faiyazuddin, Rajni Tanwar, Pooja Rani, Sonia Gupta, Lalit Sharma, Debasis Mitra, Dinesh Kumar, Neeraj Choudhary, Suresh Babu Kondaveeti, Gowri Sundaram, Thomas J Webster","doi":"10.2147/NSA.S608189","DOIUrl":"10.2147/NSA.S608189","url":null,"abstract":"<p><p>The increasing demand for eco-conscious technologies to improve human health has led to the evolution of green nanomaterials as sustainable alternatives to conventional ones. This review highlights recent advances in the eco-friendly synthesis of nanomaterials, particularly ZnO, TiO₂, graphene, and carbon-based nanostructures, using biological entities, green solvents, and mechanochemical techniques. These methods not only reduce environmental impact but also endow nanomaterials with enhanced electronic and optoelectronic properties, such as tunable band gaps, improved charge transport, and photo-responsiveness that can have a positive impact on human health. The integration of phytochemicals and microbial agents into synthesis protocols has yielded nanomaterials with superior stability, biocompatibility, and functionality, facilitating their application in energy devices, flexible electronics, biosensors, and environmental remediation. Furthermore, green-synthesized nanomaterials demonstrate reduced toxicity and improved biodegradability, as reported in comparative studies using zebrafish embryo and mammalian fibroblast models underscoring their potential in sustainable electronics. This review also addresses challenges in scalability, reproducibility, and regulatory compliance, while proposing future research directions toward smart, adaptive, and bio-integrated nanotechnologies that are better for human health.</p>","PeriodicalId":18881,"journal":{"name":"Nanotechnology, Science and Applications","volume":"19 ","pages":"608189"},"PeriodicalIF":7.6,"publicationDate":"2026-10-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13666555/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149195349","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Functionalized Colloidal Hydroxyapatite for Combined Delivery of Cannabidiol and Epirubicin: Characterization, Biomimetic Membrane Interaction, and Cytotoxicity Studies.","authors":"Paulina Końska, Magdalena Osial, Daria Paulina Kępińska, Jan Taudul, Sławomir Wilczewski, Emilia Świątek, Agnieszka Majkowska-Pilip, Kinga Żelechowska-Matysiak, Thu Phuong Nguyen, Paweł Krysiński, Dorota Nieciecka","doi":"10.2147/NSA.S617933","DOIUrl":"10.2147/NSA.S617933","url":null,"abstract":"<p><strong>Introduction: </strong>A stable colloidal hydroxyapatite (cHAp) platform was successfully developed for the co-delivery of cannabidiol (CBD), a natural bioactive compound, and epirubicin (EPI), a chemotherapeutic agent, to enhance cytotoxicity against ovarian cancer cells.</p><p><strong>Methods: </strong>Colloidal cHAp was synthesized and functionalized with CBD and EPI to obtain a multifunctional drug delivery system. The resulting composite was characterized using high-performance liquid chromatography, UV-Vis spectrometry, transmission and scanning electron microscopies, Fourier-transform infrared spectroscopy, Turbiscan analysis, and differential scanning calorimetry. Drug release in phosphate-buffered saline (PBS, pH 7) was evaluated by differential pulse voltammetry. Interactions with model lipid monolayers mimicking healthy and cancerous cell membranes were investigated using the Langmuir technique, and cytotoxicity was assessed by MTS assays.</p><p><strong>Results: </strong>The successful incorporation of both biologically active compounds into the cHAp carrier and its excellent colloidal stability were confirmed. The epirubicin loading content was 0.0605 mg per 1 mg of cHAp. Drug release followed a time-dependent profile, reaching approximately 2 μg mL^-1 after 24 h. The functionalized cHAp systems exhibited enhanced affinity toward model lipid monolayers and significantly reduced the viability of ovarian cancer cells compared with the free drug and non-functionalized carrier.</p><p><strong>Conclusion: </strong>The developed cHAp platform provides a stable and multifunctional carrier for the co-delivery of CBD and epirubicin. Its favorable physicochemical properties, enhanced membrane interactions, and improved anticancer activity highlight its potential as a promising nanocarrier for targeted ovarian cancer therapy.</p>","PeriodicalId":18881,"journal":{"name":"Nanotechnology, Science and Applications","volume":"19 ","pages":"617933"},"PeriodicalIF":7.6,"publicationDate":"2026-09-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13617019/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149075367","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Transforming Nanomaterials Development with Artificial Intelligence Techniques.","authors":"Marwan Al-Raeei","doi":"10.2147/NSA.S641862","DOIUrl":"10.2147/NSA.S641862","url":null,"abstract":"<p><p>The integration of Artificial Intelligence (AI) into various scientific fields is reshaping traditional methodologies, and nanotechnology is no exception. This article explores the transformative impact of AI on nanotechnology, a domain focused on manipulating matter at atomic and molecular scales to develop novel materials with tailored properties. Historically, the discovery and optimization of nanomaterials relied on labor-intensive trial-and-error methods, often taking years to yield practical results. We examine how recent advances in AI particularly machine learning (ML), deep learning, and reinforcement learning are revolutionizing every stage of nanomaterials research, from design and characterization to fabrication and multiscale modeling. Our discussion highlights how predictive models, trained on extensive datasets, enable rapid virtual screening of hypothetical nanostructures, significantly reducing development timelines and resource expenditure. AI-enhanced microscopy techniques, such as convolutional neural networks, improve the speed and accuracy of nanomaterial characterization, even in the presence of noisy data. Additionally, AI-driven optimization algorithms facilitate precise control over nanofabrication processes, resulting in higher reproducibility and yield, as well as the creation of more complex structures. Surrogate models trained via AI enable efficient multiscale simulations that bridge quantum mechanics and macroscopic behaviors, which are essential for understanding and predicting nanomaterial performance at larger scales. Despite these advancements, challenges such as data quality, model interpretability, and integration with experimental workflows persist. Our review emphasizes that addressing these systemic issues is crucial for fully harnessing AI's potential in nanotechnology, ultimately paving the way for accelerated innovation and the development of next-generation nanodevices with unprecedented functionalities.</p>","PeriodicalId":18881,"journal":{"name":"Nanotechnology, Science and Applications","volume":"19 ","pages":"641862"},"PeriodicalIF":7.6,"publicationDate":"2026-09-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13599800/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149039927","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Three Noble Metal Nanoparticles Demonstrated Distinct Biological Interactions and Cell Death Pathways in Human Hepatocarcinoma Cell Lines [Response to Letter].","authors":"Kacper Wiktorowski, Kamila Podsiadło, Nasrin Abbasi Gharibkandi, Sylwia Michlewska, Katarzyna D Kania, Aleksander Bilewicz, Agnieszka Majkowska-Pilip, Marzena Szwed","doi":"10.2147/NSA.S650354","DOIUrl":"10.2147/NSA.S650354","url":null,"abstract":"","PeriodicalId":18881,"journal":{"name":"Nanotechnology, Science and Applications","volume":"19 ","pages":"650354"},"PeriodicalIF":7.6,"publicationDate":"2026-09-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13596105/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149025528","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Methodological and Statistical Concerns Regarding \"Nanofiber Matrix Dressing for Split-Thickness Skin Graft Donor Sites\" [Response To Letter].","authors":"Maciej Biskupski, Sergey Antonov, Zofia Małgorzata Górecka, Rafał Wójcik, Katarzyna Żuchowska, Marek Majewski, Kamil Torres","doi":"10.2147/NSA.S652137","DOIUrl":"10.2147/NSA.S652137","url":null,"abstract":"","PeriodicalId":18881,"journal":{"name":"Nanotechnology, Science and Applications","volume":"19 ","pages":"652137"},"PeriodicalIF":7.6,"publicationDate":"2026-09-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13573785/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148970174","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Methodological and Statistical Concerns Regarding \"Nanofiber Matrix Dressing for Split-Thickness Skin Graft Donor Sites\" [Letter].","authors":"Xun He","doi":"10.2147/NSA.S649726","DOIUrl":"10.2147/NSA.S649726","url":null,"abstract":"","PeriodicalId":18881,"journal":{"name":"Nanotechnology, Science and Applications","volume":"19 ","pages":"649726"},"PeriodicalIF":7.6,"publicationDate":"2026-09-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13549321/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148906821","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Applications and Emergent Solutions for the Nanofood Industry and Nanoagriculture: Technology Landscape, Market Analysis, and Patent Trends.","authors":"Malgorzata Kus-Liskiewicz, Justyna Gawel, Paula Coutinho","doi":"10.2147/NSA.S621362","DOIUrl":"10.2147/NSA.S621362","url":null,"abstract":"<p><p>Nanotechnology is increasingly recognized as a key enabling technology for addressing critical challenges in the global agri-food system, including food security, sustainability, and resource efficiency. As the industry seeks to enhance productivity while reducing environmental impact, nano-enabled solutions such as nanofertilizers, nanopesticides, and veterinary delivery systems are becoming pivotal in driving agricultural innovation. This review provides a comprehensive literature narrative review of current and emerging nano-enabled applications in food systems and agriculture, spanning nanoencapsulation, nanoemulsions, nanocomposites, and nanosensors designed for improved bioavailability, stability, and safety. Beyond purely technological developments, the work integrates a market analysis and a patent landscape evaluation (using Espacenet) to identify innovation trajectories and commercialization trends. The most recent developments highlights the emerging convergence of nanotechnology with digitalization, including Artificial Intelligence (AI) and the Internet of Things (IoT), highly relevant for precision agriculture, and smart food systems, which is expected to play a key role in translating scientific advances into socially accepted and commercially viable solutions. Nevertheless,despite promising technological and commercial indicators, a significant finding is that most nano-enabled solutions remain incremental formulation-based innovations. Scalability, safety concerns, and the lack of regulatory harmonization represent the primary barriers to widespread adoption. Ultimately, this work emphasizes that a responsible and scalable transition to nanofood and nanoagriculture systems requires integrated, interdisciplinary approaches and a clear focus on overcoming existing commercial and safety hurdles, namely regarding harmonized risk assessment frameworks, standardized characterization methods, and life-cycle-based evaluations.</p>","PeriodicalId":18881,"journal":{"name":"Nanotechnology, Science and Applications","volume":"19 ","pages":"621362"},"PeriodicalIF":7.6,"publicationDate":"2026-08-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13526153/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148865261","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Three Noble Metal Nanoparticles Demonstrated Distinct Biological Interactions and Cell Death Pathways in Human Hepatocarcinoma Cell Lines [Letter].","authors":"Danfeng Shen, Hongxing Xu","doi":"10.2147/NSA.S644034","DOIUrl":"10.2147/NSA.S644034","url":null,"abstract":"","PeriodicalId":18881,"journal":{"name":"Nanotechnology, Science and Applications","volume":"19 ","pages":"644034"},"PeriodicalIF":7.6,"publicationDate":"2026-08-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13502227/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148813466","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Nanotechnological Advances in Ocular Therapeutics: A Narrative Review of Drug Delivery Platforms, Clinical Applications, and Translational Challenges.","authors":"Uday Pratap Singh Parmar, Rohan Bir Singh, Shilpy Bhullar, Rudraksh Gupta, Ankit Gauba, Maryam Shayan, Karima Rai, Parul Ichhpujani","doi":"10.2147/NSA.S611594","DOIUrl":"https://doi.org/10.2147/NSA.S611594","url":null,"abstract":"<p><strong>Purpose: </strong>Nanotechnology-based ocular drug delivery systems offer a promising approach to overcoming the anatomical and physiological barriers that limit the efficacy of conventional ophthalmic formulations, where topical bioavailability typically remains below 5% owing to rapid nasolacrimal drainage, precorneal tear turnover, and corneal impermeability. This narrative review synthesises current evidence on nanocarrier design, delivery pathways, and disease-specific therapeutic applications, incorporating cross-platform comparison across six nanocarrier systems and explicit stratification of evidence by translational stage.</p><p><strong>Methods: </strong>A structured narrative review was conducted using OVID MEDLINE, Embase, Scopus, Web of Science, and PubMed from database inception to September 2025, supplemented by citation chaining and targeted Google Scholar searches. Data extraction focused on carrier architecture, drug-loading and release characteristics, delivery routes, mechanistic behaviour, therapeutic outcomes, and safety profiles. This review was conducted in accordance with the general principles for narrative reviews as described in the Scale for the Assessment of Narrative Review Articles (SANRA).</p><p><strong>Results: </strong>Key nanocarrier classes included liposomes, polymeric micelles, dendrimers, nanosuspensions, nanoemulsions, and chitosan- and protein-based nanoparticles. Compared with conventional formulations, these systems demonstrated improved corneal residence, enhanced mucoadhesion, increased transscleral diffusion, reduced dosing frequency, and sustained intraocular exposure. Clinically translated examples include cyclosporine A nanomicelle and nanoemulsion formulations, marketed as Cequa (0.09%), Restasis (0.05%), and Ikervis (0.1%), approved for dry eye disease, and a subconjunctival PLGA nanoparticle depot that achieved greater than 20% intraocular pressure reduction sustained over 90 days from a single injection in early clinical evaluation. Applications spanned anterior-segment disorders, including dry eye disease, conjunctivitis, infectious keratitis, ocular inflammation, and glaucoma, and posterior-segment diseases such as diabetic retinopathy, age-related macular degeneration, retinoblastoma, and retinopathy of prematurity.</p><p><strong>Conclusion: </strong>Lipid-based and polymeric nanocarrier platforms are currently closest to clinical translation, with approved formulations and early-phase trial data supporting meaningful therapeutic advantages over conventional delivery. Realising the full potential of ocular nanomedicine will require addressing residual challenges in long-term ocular safety, manufacturing scalability, and regulatory compliance, particularly for posterior-segment applications, where non-invasive topical delivery remains largely at the preclinical stage.</p>","PeriodicalId":18881,"journal":{"name":"Nanotechnology, Science and Applications","volume":"19 ","pages":"611594"},"PeriodicalIF":7.6,"publicationDate":"2026-08-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13480357/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148795729","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}