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Cell Line-Dependent Adhesion and Inhibition of Proliferation on Carbon-Based Nanofilms. 碳基纳米薄膜上的细胞线依赖性粘附和增殖抑制。
IF 4.9
Nanotechnology, Science and Applications Pub Date : 2023-12-14 eCollection Date: 2023-01-01 DOI: 10.2147/NSA.S439185
Barbara Wójcik, Katarzyna Zawadzka, Ewa Sawosz, Malwina Sosnowska, Agnieszka Ostrowska, Mateusz Wierzbicki
{"title":"Cell Line-Dependent Adhesion and Inhibition of Proliferation on Carbon-Based Nanofilms.","authors":"Barbara Wójcik, Katarzyna Zawadzka, Ewa Sawosz, Malwina Sosnowska, Agnieszka Ostrowska, Mateusz Wierzbicki","doi":"10.2147/NSA.S439185","DOIUrl":"https://doi.org/10.2147/NSA.S439185","url":null,"abstract":"<p><strong>Introduction: </strong>Disorganisation of the extracellular matrix (ECM) is strongly connected to tumor progression. Even small-scale changes can significantly influence the adhesion and proliferation of cancer cells. Therefore, the use of biocompatible nanomaterials capable of supporting and partially replenishing degraded ECM might be essential to recover the niche after tumor resection. The objective of this study was to evaluate the influence of graphene, graphene oxide, fullerene, and diamond nanofilms on breast cancer and glioblastoma grade IV cell lines.</p><p><strong>Methods: </strong>Nanomaterials were characterized using SEM and TEM techniques; zeta potential analysis was also performed. Nanofilms of graphene, fullerene, and diamond nanoparticles were also characterized using AFM. The toxicity was tested on breast cancer MDA.MB.231 and glioblastoma grade IV U-87 MG cell lines, using LDH assay and by counting stained dead cells in bioprinted 3D models. The following parameters were analyzed: proliferation, adhesion to the nanofilm, and adhesion to particular ECM components covered with diamond nanoparticles.</p><p><strong>Results and discussion: </strong>Our studies demonstrated that nanofilms of graphene and diamond nanoparticles are characterized by cell-specific toxicity. Those nanomaterials were non-toxic to MDA.MB.231 cells. After applying bioprinted 3D models, diamond nanoparticles were not toxic for both cell lines. Nanofilms made of diamond nanoparticles and graphene inhibit the proliferation of MDA.MB.231 cells after 48 and 72 hours. Increased adhesion on nanofilm made of diamond nanoparticles was only observed for MDA.MB.231 cells after 30 and 60 minutes from seeding the cells. However, analysis of adhesion to certain ECM components coated with diamond nanoparticles revealed enhanced adhesion to tenascin and vitronectin for both tested cell lines.</p><p><strong>Conclusion: </strong>Our studies show that nanofilm made of diamond nanoparticles is a non-toxic and pro-adhesive nanomaterial that might stabilize and partially replenish the niche after breast tumor resection as it enhances the adhesion of breast cancer cells and inhibits their proliferation.</p>","PeriodicalId":18881,"journal":{"name":"Nanotechnology, Science and Applications","volume":"16 ","pages":"41-57"},"PeriodicalIF":4.9,"publicationDate":"2023-12-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10726834/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138807987","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Green Nanotechnology of Yucca filamentosa- Phytochemicals-Functionalized Gold Nanoparticles-Antitumor Efficacy Against Prostate and Breast Cancers. 丝兰绿色纳米技术--植物化学物质--功能化金纳米粒子--对前列腺癌和乳腺癌的抗肿瘤功效
IF 4.9
Nanotechnology, Science and Applications Pub Date : 2023-12-11 eCollection Date: 2023-01-01 DOI: 10.2147/NSA.S437812
Velaphi C Thipe, Ananya Jatar, Alice Raphael Karikachery, Kavita K Katti, Kattesh V Katti
{"title":"Green Nanotechnology of <i>Yucca filamentosa</i>- Phytochemicals-Functionalized Gold Nanoparticles-Antitumor Efficacy Against Prostate and Breast Cancers.","authors":"Velaphi C Thipe, Ananya Jatar, Alice Raphael Karikachery, Kavita K Katti, Kattesh V Katti","doi":"10.2147/NSA.S437812","DOIUrl":"https://doi.org/10.2147/NSA.S437812","url":null,"abstract":"<p><strong>Purpose: </strong>We report an innovative green nanotechnology utilizing an electron-rich cocktail of phytochemicals from <i>Yucca filamentosa</i> L. to synthesize biocompatible gold nanoparticles without the use of any external chemical reducing agents and evaluate their anti-cancer activity.</p><p><strong>Methods: </strong><i>Yucca filamentosa</i> L. extract, containing a cocktail of phytochemicals, was prepared, and used to transform gold salt into <i>Y. filamentosa</i> phytochemicals encapsulated gold nanoparticles (YF-AuNPs). Additionally, gum arabic stabilized YF-AuNPs (GAYF-AuNPs) were also prepared to enhance the in vitro/in vivo stability. Anticancer activity was evaluated against prostate (PC-3) and breast (MDAMB-231) cancer cell lines. Targeting abilities of gold nanoparticles were tested using pro-tumor macrophage cell lines.</p><p><strong>Results: </strong>Comprehensive characterization of new nanomedicine agents YF-AuNPs and GAYF-AuNPs revealed spherical, and monodisperse AuNPs with moderate zeta potentials (-19 and -20 mV, respectively), indicating in vitro/in vivo stability. The core size of YF-AuNPs (14 ± 5 nm) and GAYF-AuNPs (10 ± 5 nm) is suitable for optimal penetration into tumor cells through both enhanced permeability and retention (EPR) effect as well as through the receptor mediated endocytosis. Notably, YF-AuNPs exhibited potent anticancer activity against prostate (PC-3) and breast tumors (MDAMB-231) by inducing early and late apoptotic stages. Moreover, YF-AuNPs resulted in elevated levels of anti-tumor cytokines (TNF-α and IL-12) and reduced levels of pro-tumor cytokines (IL-6 and IL-10), provide compelling evidence on the immunomodulatory property of YF-AuNPs.</p><p><strong>Conclusion: </strong>Overall, these <i>Y. filamentosa</i> phytochemicals functionalized nano-Ayurvedic medicine agents demonstrated selective toxicity to cancer cells while sparing normal cells. Most notably, to our knowledge, this is the first study that shows YF-AuNP's targeting efficacy toward pro-tumor macrophage cell lines, suggesting an immunomodulatory pathway for cancer treatment. This work introduces a novel avenue for herbal and nano-Ayurvedic approaches to human cancer treatment, mediated through selective efficacy and immunomodulatory potential.</p>","PeriodicalId":18881,"journal":{"name":"Nanotechnology, Science and Applications","volume":"16 ","pages":"19-40"},"PeriodicalIF":4.9,"publicationDate":"2023-12-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10723618/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138807988","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Chitosan-Coated Azithromycin/Ciprofloxacin-Loaded Polycaprolactone Nanoparticles: A Characterization and Potency Study 壳聚糖包覆的阿奇霉素/环丙沙星负载型聚己内酯纳米颗粒:特性和药效研究
IF 4.9
Nanotechnology, Science and Applications Pub Date : 2023-12-01 DOI: 10.2147/nsa.s438484
Alaa B. Yassin, Abdulkareem Albekairy, Mustafa E. Omer, Arwa Almutairi, Yousef Alotaibi, Salem Althuwaini, Osama Alaql, Shahad Almozaai, Nouf Almutiri, Wed Alluhaim, Raghad Alzahrani, Asma Alterawi, Majed Halwani
{"title":"Chitosan-Coated Azithromycin/Ciprofloxacin-Loaded Polycaprolactone Nanoparticles: A Characterization and Potency Study","authors":"Alaa B. Yassin, Abdulkareem Albekairy, Mustafa E. Omer, Arwa Almutairi, Yousef Alotaibi, Salem Althuwaini, Osama Alaql, Shahad Almozaai, Nouf Almutiri, Wed Alluhaim, Raghad Alzahrani, Asma Alterawi, Majed Halwani","doi":"10.2147/nsa.s438484","DOIUrl":"https://doi.org/10.2147/nsa.s438484","url":null,"abstract":"","PeriodicalId":18881,"journal":{"name":"Nanotechnology, Science and Applications","volume":"393 ","pages":""},"PeriodicalIF":4.9,"publicationDate":"2023-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139020188","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Graphene Oxide Decreases Pro-Inflammatory Proteins Production in Skeletal Muscle Cells Exposed to SARS-CoV-2 Spike Protein. 氧化石墨烯减少暴露于SARS-CoV-2刺突蛋白的骨骼肌细胞中促炎蛋白的产生
IF 4.9
Nanotechnology, Science and Applications Pub Date : 2023-01-01 DOI: 10.2147/NSA.S391761
Jaśmina Bałaban, Mateusz Wierzbicki, Marlena Zielińska-Górska, Malwina Sosnowska, Karolina Daniluk, Sławomir Jaworski, Piotr Koczoń, Dominik Cysewski, André Chwalibog, Ewa Sawosz
{"title":"Graphene Oxide Decreases Pro-Inflammatory Proteins Production in Skeletal Muscle Cells Exposed to SARS-CoV-2 Spike Protein.","authors":"Jaśmina Bałaban,&nbsp;Mateusz Wierzbicki,&nbsp;Marlena Zielińska-Górska,&nbsp;Malwina Sosnowska,&nbsp;Karolina Daniluk,&nbsp;Sławomir Jaworski,&nbsp;Piotr Koczoń,&nbsp;Dominik Cysewski,&nbsp;André Chwalibog,&nbsp;Ewa Sawosz","doi":"10.2147/NSA.S391761","DOIUrl":"https://doi.org/10.2147/NSA.S391761","url":null,"abstract":"Aim The experiments aimed to document the presence of the ACE2 receptor on human muscle cells and the effects of the interaction of these cells with the spike protein of the SARS-CoV-2 virus in terms of induction of pro-inflammatory proteins, as well as to assess the possibility of reducing the pool of these proteins with the use of graphene oxide (GO) flakes. Methods Human Skeletal Myoblast (HSkM), purchased from Gibco were maintained in standard condition according to the manufacturer’s instruction. The cells were divided into 4 groups; 1. C-control, 2. S-with addition of spike protein, 3. GO-with the addition of graphene oxide, 4. GO-S-with addition of GO followed by the addition of S protein. Protein S (PX-COV-P049) was purchased from ProteoGenix (France). GO was obtained from Advanced Graphene Products (Zielona Gora, Poland). The influence of all the factors on the morphology of cells was investigated using light and confocal microscopy. ACE2 protein expression on muscle cells was visualized and 40 pro-inflammatory cytokines were investigated using the membrane antibody array method. The protein profile of the lysate of cells from individual groups was also analyzed by mass spectrometry. Conclusion The experiments confirmed the presence of the ACE2 receptor in human skeletal muscle cells. It has also been documented that the SARS-CoV-2 virus spike protein influences the activation of selected pro-inflammatory proteins that promote cytokine storm and oxidative stress in muscle cells. The use of low levels of graphene oxide does not adversely affect muscle cells, reducing the levels of most proteins, including pro-inflammatory proteins. It can be assumed that GO may support anti-inflammatory therapy in muscles by scavenging proteins that activate cytokine storm.","PeriodicalId":18881,"journal":{"name":"Nanotechnology, Science and Applications","volume":"16 ","pages":"1-18"},"PeriodicalIF":4.9,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/3b/13/nsa-16-1.PMC9869801.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10615267","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
EGF Receptor-Targeting Cancer Therapy Using CD47-Engineered Cell-Derived Nanoplatforms. 利用cd47工程细胞衍生的纳米平台靶向EGF受体治疗癌症。
IF 4.9
Nanotechnology, Science and Applications Pub Date : 2022-07-05 eCollection Date: 2022-01-01 DOI: 10.2147/NSA.S352038
Moon Jung Choi, Kang Chan Choi, Do Hyun Lee, Hwa Yeon Jeong, Seong Jae Kang, Min Woo Kim, In Ho Jeong, Young Myoung You, Jin Suk Lee, Yeon Kyung Lee, Chan Su Im, Yong Serk Park
{"title":"EGF Receptor-Targeting Cancer Therapy Using CD47-Engineered Cell-Derived Nanoplatforms.","authors":"Moon Jung Choi,&nbsp;Kang Chan Choi,&nbsp;Do Hyun Lee,&nbsp;Hwa Yeon Jeong,&nbsp;Seong Jae Kang,&nbsp;Min Woo Kim,&nbsp;In Ho Jeong,&nbsp;Young Myoung You,&nbsp;Jin Suk Lee,&nbsp;Yeon Kyung Lee,&nbsp;Chan Su Im,&nbsp;Yong Serk Park","doi":"10.2147/NSA.S352038","DOIUrl":"https://doi.org/10.2147/NSA.S352038","url":null,"abstract":"<p><strong>Introduction: </strong>Avoiding phagocytic cells and reducing off-target toxicity are the primary hurdles in the clinical application of nanoparticles containing therapeutics. For overcoming these errors, in this study, nanoparticles expressing CD47 proteins inhibiting the phagocytic attack of immune cells were prepared and then evaluated as an anti-cancer drug delivery vehicle.</p><p><strong>Methods: </strong>The CD47+ cell-derived nanoparticles (CDNs) were prepared from the plasma membranes of human embryonic kidney cells transfected with a plasmid encoding CD47. And the doxorubicin (DOX) was loaded into the CDNs, and anti-EGF receptor (EGFR) antibodies were conjugated to the surface of the CDNs to target tumors overexpressing EGFR.</p><p><strong>Results: </strong>The CD47+iCDNs-DOX was successfully synthesized having a stable structure. The CD47+CDNs were taken up less by RAW264.7 macrophages compared to control CDNs. Anti-EGFR CD47+CDNs (iCDNs) selectively recognized EGFR-positive MDA-MB-231 cells in vitro and accumulated more effectively in the target tumor xenografts in mice. Moreover, iCDNs encapsulating doxorubicin (iCDNs-DOX) exhibited the highest suppression of tumor growth in mice, presumably due to the enhanced DOX delivery to tumor tissues, compared to non-targeting CDNs or CD47- iCDNs.</p><p><strong>Discussion: </strong>These results suggest that the clinical application of biocompatible cell membrane-derived nanocarriers could be facilitated by functionalization with macrophage-avoiding CD47 and tumor-targeting antibodies.</p>","PeriodicalId":18881,"journal":{"name":"Nanotechnology, Science and Applications","volume":" ","pages":"17-31"},"PeriodicalIF":4.9,"publicationDate":"2022-07-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/61/95/nsa-15-17.PMC9270928.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40582335","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 2
Parallel Multichannel Assessment of Rotationally Manipulated Magnetic Nanoparticles. 旋转操纵磁性纳米颗粒的并行多通道评估
IF 4.9
Nanotechnology, Science and Applications Pub Date : 2022-04-19 eCollection Date: 2022-01-01 DOI: 10.2147/NSA.S358931
Syed I Hussain, Lamar O Mair, Alexander J Willis, Georgia Papavasiliou, Bing Liu, Irving N Weinberg, Herbert H Engelhard
{"title":"Parallel Multichannel Assessment of Rotationally Manipulated Magnetic Nanoparticles.","authors":"Syed I Hussain, Lamar O Mair, Alexander J Willis, Georgia Papavasiliou, Bing Liu, Irving N Weinberg, Herbert H Engelhard","doi":"10.2147/NSA.S358931","DOIUrl":"10.2147/NSA.S358931","url":null,"abstract":"<p><strong>Background: </strong>Rotational manipulation of chains or clusters of magnetic nanoparticles (MNPs) offers a means for directed translation and payload delivery that should be explored for clinical use. Multiple MNP types are available, yet few studies have performed side-by-side comparisons to evaluate characteristics such as velocity, movement at a distance, and capacity for drug conveyance or dispersion.</p><p><strong>Purpose: </strong>Our goal was to design, build, and study an electric device allowing simultaneous, multichannel testing (e.g., racing) of MNPs in response to a rotating magnetic field. We would then select the \"best\" MNP and use it with optimized device settings, to transport an unbound therapeutic agent.</p><p><strong>Methods: </strong>A magnetomotive system was constructed, with a Helmholtz pair of coils on either side of a single perpendicular coil, on top of which was placed an acrylic tray having multiple parallel lanes. Five different MNPs were tested: graphene-coated cobalt MNPs (TurboBeads™), nickel nanorods, gold-iron alloy MNPs, gold-coated Fe<sub>3</sub>O<sub>4</sub> MNPs, and uncoated Fe<sub>3</sub>O<sub>4</sub> MNPs. Velocities were determined in response to varying magnetic field frequencies (5-200 Hz) and heights (0-18 cm). Velocities were normalized to account for minor lane differences. Doxorubicin was chosen as the therapeutic agent, assayed using a CLARIOstar Plus microplate reader.</p><p><strong>Results: </strong>The MMS generated a maximal MNP velocity of 0.9 cm/s. All MNPs encountered a \"critical\" frequency at 20-30 Hz. Nickel nanorods had the optimal response based on tray height and were then shown to enable unbound doxorubicin dispersion along 10.5 cm in <30 sec.</p><p><strong>Conclusion: </strong>A rotating magnetic field can be conveniently generated using a three-coil electromagnetic device, and used to induce rotational and translational movement of MNP aggregates over mesoscale distances. The responses of various MNPs can be compared side-by-side using multichannel acrylic trays to assess suitability for drug delivery, highlighting their potential for further in vivo applications.</p>","PeriodicalId":18881,"journal":{"name":"Nanotechnology, Science and Applications","volume":"15 1","pages":"1-15"},"PeriodicalIF":4.9,"publicationDate":"2022-04-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9034901/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41443951","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Dielectric Behavior and Transport Properties of Electrospun Polyvinylidene Fluoride Nanofiber Membrane 静电纺聚偏氟乙烯纳米纤维膜的介电行为和输运性能
IF 4.9
Nanotechnology, Science and Applications Pub Date : 2021-12-30 DOI: 10.33425/2639-9466.1027
Sharvare Palwai, A. Batra, K. Arun, Ashok Vaseashta
{"title":"Dielectric Behavior and Transport Properties of Electrospun Polyvinylidene Fluoride Nanofiber Membrane","authors":"Sharvare Palwai, A. Batra, K. Arun, Ashok Vaseashta","doi":"10.33425/2639-9466.1027","DOIUrl":"https://doi.org/10.33425/2639-9466.1027","url":null,"abstract":"Poly (vinylidene fluoride) (PVDF) is a chemical resistance polymer with high ferroelectric, piezoelectric and pyroelectric properties. PVDF has been chosen due to its unique properties compared with others in the polymers family and is used in a variety of sensors and transducers. A PVDF nanofiber membrane with relatively uniform morphology was prepared by an electrospinning technique. The surface morphology of the electrospun PVDF nanofibers was observed by scanning electron microscopy (SEM). The microstructure of electrospun PVDF nanofibers was characterized by Fourier Transform Infrared spectroscopy (FTIR) in the range 400 to 4000 cm-1. The functional groups were identified in the membrane. Infrared vibrational spectroscopy (FTIR + Raman) curves revealed a ferroelectric β-phase in the un-annealed membrane intrinsically. It showed that the electrospinning technique induce crystalline and polar β-phase by applying an electric field to the PVDF polymer solution during high solution jet stretching. The membrane (7 mm x5 mm) with full-face copper electrodes was produced to form a capacitor for testing.","PeriodicalId":18881,"journal":{"name":"Nanotechnology, Science and Applications","volume":"30 1","pages":""},"PeriodicalIF":4.9,"publicationDate":"2021-12-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"78235642","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Effect of Chemically Modified Castor Seed (Ricinus Communis) Shell Powder on The Mechanical Properties of Natural Rubber Vulcanizate 化学改性蓖麻籽壳粉对天然硫化橡胶力学性能的影响
IF 4.9
Nanotechnology, Science and Applications Pub Date : 2021-12-30 DOI: 10.33425/2639-9466.1028
Tenebe O.G, Madufor I.C, Obidiegwu M.U, O. H.C
{"title":"Effect of Chemically Modified Castor Seed (Ricinus Communis) Shell Powder on The Mechanical Properties of Natural Rubber Vulcanizate","authors":"Tenebe O.G, Madufor I.C, Obidiegwu M.U, O. H.C","doi":"10.33425/2639-9466.1028","DOIUrl":"https://doi.org/10.33425/2639-9466.1028","url":null,"abstract":"Mechanical properties of natural rubber filled with modified castor seed shell powder for some engineering applications were studied. Castor seed shells were obtained and treated with 20% NaOH for 1h, washed and dried at 75oC and were pulverized and sieved to 75μm. Treated castor seed shell (TCSS) powder showed improved characteristics when compared to the untreated (UCSS) in terms of pH, bulk density, moisture content, lignin content, cellulose content, hemicelluloses content, thermal stability, SEM and FTIR spectra respectively. Natural rubber was compounded at varying filler loadings of 0, 10, 20, 30, 40 and 50phr on a two-roll mill. The cure characteristics of the compounded rubber were determined using a Mosanto Rheometer (model MDR 2000) and the result obtained were used for vulcanization in a hydraulic press. The cure characteristics, mechanical and morphological properties of the vulcanizates were analysed and compared with carbon black filled samples. The preliminary results showed that castor seed shell is hydrophilic which was chemically treated to decrease the hydrophilicity. The maximum and minimum torques increased with filler loadings. The result of the natural rubber filled vulcanizates showed improved mechanical properties such as; tensile strength, modulus, tear strength, hardness, abrasion resistance which increased with increased filler loadings while elongation at break, flex fatigue, compression set, impact strength and rebound resilience decreased with filler loadings. The TCSS filled vulcanizate showed superior abrasion resistance and compression set when compared with UCSS and CB filled. The sample morphology at 30phr revealed that TCSS was well dispersed due to strong interfacial adhesion between the filler and the matrices contributing to the improved mechanical properties investigated when compared to UCSS filled with poor interfacial interaction. The result reveal that TCSS is a reinforcing filler that can be used for the production of natural rubber-based products for some engineering applications.","PeriodicalId":18881,"journal":{"name":"Nanotechnology, Science and Applications","volume":"24 1","pages":""},"PeriodicalIF":4.9,"publicationDate":"2021-12-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"86601524","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Synthesis of Polymeric (Self-Disappearing) Nano Medical Patches Loaded with a Long-Acting Pharmacological Substance by Electrospinning Method 静电纺丝法合成负载长效药理学物质的高分子(自消失)纳米医用贴片
IF 4.9
Nanotechnology, Science and Applications Pub Date : 2021-12-30 DOI: 10.33425/2639-9466.1029
Alia Hindi, Mohammad Yahia Masri, S. Hardcastle, M. Batal
{"title":"Synthesis of Polymeric (Self-Disappearing) Nano Medical Patches Loaded with a Long-Acting Pharmacological Substance by Electrospinning Method","authors":"Alia Hindi, Mohammad Yahia Masri, S. Hardcastle, M. Batal","doi":"10.33425/2639-9466.1029","DOIUrl":"https://doi.org/10.33425/2639-9466.1029","url":null,"abstract":"Nano-polymer (self-disappearing) medical patches loaded with a long-acting drug were manufactured by cospinning method of synthetic polymers PVA and PVP at a rate of 10%W for each polymer and with the addition different medicinal substances, namely diclofenac de ethylamine, gentamicin, in concentration 5%w (each substance separately). And studding the morphological structure of the prepared samples by scanning electron microscope (SEM) and X- Ray diffraction (XRD), then converted into a medical adhesive form, and then tested on the human hand directly, as it has proven its effectiveness in delivering the drug to the affected area directly. It is very easy to use, medically safe and economic, as it does not need huge industrial equipment for its production.","PeriodicalId":18881,"journal":{"name":"Nanotechnology, Science and Applications","volume":"67 1","pages":""},"PeriodicalIF":4.9,"publicationDate":"2021-12-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"79635998","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Nanomaterials and Rare Earths Used To Evaluate the Photocatalytic Degradation of a Dye, with Potential Use in Decontaminating Water Bodies 纳米材料和稀土用于评价染料光催化降解及其在水体净化中的潜在应用
IF 4.9
Nanotechnology, Science and Applications Pub Date : 2021-12-30 DOI: 10.33425/2639-9466.1026
Naranjo-Castañeda Felix Antonio, Palacios-Grijalva Laura Nadxieli, Martínez-Jiménez Anatolio, Chávez-Sandoval Blanca Estela
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