Nanotechnology, Science and Applications最新文献

{"title":"Graphene Oxide Decreases Pro-Inflammatory Proteins Production in Skeletal Muscle Cells Exposed to SARS-CoV-2 Spike Protein.","authors":"Jaśmina Bałaban, Mateusz Wierzbicki, Marlena Zielińska-Górska, Malwina Sosnowska, Karolina Daniluk, Sławomir Jaworski, Piotr Koczoń, Dominik Cysewski, André Chwalibog, Ewa Sawosz","doi":"10.2147/NSA.S391761","DOIUrl":"https://doi.org/10.2147/NSA.S391761","url":null,"abstract":"Aim The experiments aimed to document the presence of the ACE2 receptor on human muscle cells and the effects of the interaction of these cells with the spike protein of the SARS-CoV-2 virus in terms of induction of pro-inflammatory proteins, as well as to assess the possibility of reducing the pool of these proteins with the use of graphene oxide (GO) flakes. Methods Human Skeletal Myoblast (HSkM), purchased from Gibco were maintained in standard condition according to the manufacturer’s instruction. The cells were divided into 4 groups; 1. C-control, 2. S-with addition of spike protein, 3. GO-with the addition of graphene oxide, 4. GO-S-with addition of GO followed by the addition of S protein. Protein S (PX-COV-P049) was purchased from ProteoGenix (France). GO was obtained from Advanced Graphene Products (Zielona Gora, Poland). The influence of all the factors on the morphology of cells was investigated using light and confocal microscopy. ACE2 protein expression on muscle cells was visualized and 40 pro-inflammatory cytokines were investigated using the membrane antibody array method. The protein profile of the lysate of cells from individual groups was also analyzed by mass spectrometry. Conclusion The experiments confirmed the presence of the ACE2 receptor in human skeletal muscle cells. It has also been documented that the SARS-CoV-2 virus spike protein influences the activation of selected pro-inflammatory proteins that promote cytokine storm and oxidative stress in muscle cells. The use of low levels of graphene oxide does not adversely affect muscle cells, reducing the levels of most proteins, including pro-inflammatory proteins. It can be assumed that GO may support anti-inflammatory therapy in muscles by scavenging proteins that activate cytokine storm.","PeriodicalId":18881,"journal":{"name":"Nanotechnology, Science and Applications","volume":null,"pages":null},"PeriodicalIF":4.9,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/3b/13/nsa-16-1.PMC9869801.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10615267","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"EGF Receptor-Targeting Cancer Therapy Using CD47-Engineered Cell-Derived Nanoplatforms.","authors":"Moon Jung Choi,&nbsp;Kang Chan Choi,&nbsp;Do Hyun Lee,&nbsp;Hwa Yeon Jeong,&nbsp;Seong Jae Kang,&nbsp;Min Woo Kim,&nbsp;In Ho Jeong,&nbsp;Young Myoung You,&nbsp;Jin Suk Lee,&nbsp;Yeon Kyung Lee,&nbsp;Chan Su Im,&nbsp;Yong Serk Park","doi":"10.2147/NSA.S352038","DOIUrl":"https://doi.org/10.2147/NSA.S352038","url":null,"abstract":"<p><strong>Introduction: </strong>Avoiding phagocytic cells and reducing off-target toxicity are the primary hurdles in the clinical application of nanoparticles containing therapeutics. For overcoming these errors, in this study, nanoparticles expressing CD47 proteins inhibiting the phagocytic attack of immune cells were prepared and then evaluated as an anti-cancer drug delivery vehicle.</p><p><strong>Methods: </strong>The CD47+ cell-derived nanoparticles (CDNs) were prepared from the plasma membranes of human embryonic kidney cells transfected with a plasmid encoding CD47. And the doxorubicin (DOX) was loaded into the CDNs, and anti-EGF receptor (EGFR) antibodies were conjugated to the surface of the CDNs to target tumors overexpressing EGFR.</p><p><strong>Results: </strong>The CD47+iCDNs-DOX was successfully synthesized having a stable structure. The CD47+CDNs were taken up less by RAW264.7 macrophages compared to control CDNs. Anti-EGFR CD47+CDNs (iCDNs) selectively recognized EGFR-positive MDA-MB-231 cells in vitro and accumulated more effectively in the target tumor xenografts in mice. Moreover, iCDNs encapsulating doxorubicin (iCDNs-DOX) exhibited the highest suppression of tumor growth in mice, presumably due to the enhanced DOX delivery to tumor tissues, compared to non-targeting CDNs or CD47- iCDNs.</p><p><strong>Discussion: </strong>These results suggest that the clinical application of biocompatible cell membrane-derived nanocarriers could be facilitated by functionalization with macrophage-avoiding CD47 and tumor-targeting antibodies.</p>","PeriodicalId":18881,"journal":{"name":"Nanotechnology, Science and Applications","volume":null,"pages":null},"PeriodicalIF":4.9,"publicationDate":"2022-07-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/61/95/nsa-15-17.PMC9270928.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40582335","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Parallel Multichannel Assessment of Rotationally Manipulated Magnetic Nanoparticles.","authors":"Syed I Hussain, Lamar O Mair, Alexander J Willis, Georgia Papavasiliou, Bing Liu, Irving N Weinberg, Herbert H Engelhard","doi":"10.2147/NSA.S358931","DOIUrl":"10.2147/NSA.S358931","url":null,"abstract":"<p><strong>Background: </strong>Rotational manipulation of chains or clusters of magnetic nanoparticles (MNPs) offers a means for directed translation and payload delivery that should be explored for clinical use. Multiple MNP types are available, yet few studies have performed side-by-side comparisons to evaluate characteristics such as velocity, movement at a distance, and capacity for drug conveyance or dispersion.</p><p><strong>Purpose: </strong>Our goal was to design, build, and study an electric device allowing simultaneous, multichannel testing (e.g., racing) of MNPs in response to a rotating magnetic field. We would then select the \"best\" MNP and use it with optimized device settings, to transport an unbound therapeutic agent.</p><p><strong>Methods: </strong>A magnetomotive system was constructed, with a Helmholtz pair of coils on either side of a single perpendicular coil, on top of which was placed an acrylic tray having multiple parallel lanes. Five different MNPs were tested: graphene-coated cobalt MNPs (TurboBeads™), nickel nanorods, gold-iron alloy MNPs, gold-coated Fe₃O₄ MNPs, and uncoated Fe₃O₄ MNPs. Velocities were determined in response to varying magnetic field frequencies (5-200 Hz) and heights (0-18 cm). Velocities were normalized to account for minor lane differences. Doxorubicin was chosen as the therapeutic agent, assayed using a CLARIOstar Plus microplate reader.</p><p><strong>Results: </strong>The MMS generated a maximal MNP velocity of 0.9 cm/s. All MNPs encountered a \"critical\" frequency at 20-30 Hz. Nickel nanorods had the optimal response based on tray height and were then shown to enable unbound doxorubicin dispersion along 10.5 cm in <30 sec.</p><p><strong>Conclusion: </strong>A rotating magnetic field can be conveniently generated using a three-coil electromagnetic device, and used to induce rotational and translational movement of MNP aggregates over mesoscale distances. The responses of various MNPs can be compared side-by-side using multichannel acrylic trays to assess suitability for drug delivery, highlighting their potential for further in vivo applications.</p>","PeriodicalId":18881,"journal":{"name":"Nanotechnology, Science and Applications","volume":null,"pages":null},"PeriodicalIF":4.9,"publicationDate":"2022-04-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9034901/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41443951","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Dielectric Behavior and Transport Properties of Electrospun Polyvinylidene Fluoride Nanofiber Membrane","authors":"Sharvare Palwai, A. Batra, K. Arun, Ashok Vaseashta","doi":"10.33425/2639-9466.1027","DOIUrl":"https://doi.org/10.33425/2639-9466.1027","url":null,"abstract":"Poly (vinylidene fluoride) (PVDF) is a chemical resistance polymer with high ferroelectric, piezoelectric and pyroelectric properties. PVDF has been chosen due to its unique properties compared with others in the polymers family and is used in a variety of sensors and transducers. A PVDF nanofiber membrane with relatively uniform morphology was prepared by an electrospinning technique. The surface morphology of the electrospun PVDF nanofibers was observed by scanning electron microscopy (SEM). The microstructure of electrospun PVDF nanofibers was characterized by Fourier Transform Infrared spectroscopy (FTIR) in the range 400 to 4000 cm-1. The functional groups were identified in the membrane. Infrared vibrational spectroscopy (FTIR + Raman) curves revealed a ferroelectric β-phase in the un-annealed membrane intrinsically. It showed that the electrospinning technique induce crystalline and polar β-phase by applying an electric field to the PVDF polymer solution during high solution jet stretching. The membrane (7 mm x5 mm) with full-face copper electrodes was produced to form a capacitor for testing.","PeriodicalId":18881,"journal":{"name":"Nanotechnology, Science and Applications","volume":null,"pages":null},"PeriodicalIF":4.9,"publicationDate":"2021-12-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"78235642","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effect of Chemically Modified Castor Seed (Ricinus Communis) Shell Powder on The Mechanical Properties of Natural Rubber Vulcanizate","authors":"Tenebe O.G, Madufor I.C, Obidiegwu M.U, O. H.C","doi":"10.33425/2639-9466.1028","DOIUrl":"https://doi.org/10.33425/2639-9466.1028","url":null,"abstract":"Mechanical properties of natural rubber filled with modified castor seed shell powder for some engineering applications were studied. Castor seed shells were obtained and treated with 20% NaOH for 1h, washed and dried at 75oC and were pulverized and sieved to 75μm. Treated castor seed shell (TCSS) powder showed improved characteristics when compared to the untreated (UCSS) in terms of pH, bulk density, moisture content, lignin content, cellulose content, hemicelluloses content, thermal stability, SEM and FTIR spectra respectively. Natural rubber was compounded at varying filler loadings of 0, 10, 20, 30, 40 and 50phr on a two-roll mill. The cure characteristics of the compounded rubber were determined using a Mosanto Rheometer (model MDR 2000) and the result obtained were used for vulcanization in a hydraulic press. The cure characteristics, mechanical and morphological properties of the vulcanizates were analysed and compared with carbon black filled samples. The preliminary results showed that castor seed shell is hydrophilic which was chemically treated to decrease the hydrophilicity. The maximum and minimum torques increased with filler loadings. The result of the natural rubber filled vulcanizates showed improved mechanical properties such as; tensile strength, modulus, tear strength, hardness, abrasion resistance which increased with increased filler loadings while elongation at break, flex fatigue, compression set, impact strength and rebound resilience decreased with filler loadings. The TCSS filled vulcanizate showed superior abrasion resistance and compression set when compared with UCSS and CB filled. The sample morphology at 30phr revealed that TCSS was well dispersed due to strong interfacial adhesion between the filler and the matrices contributing to the improved mechanical properties investigated when compared to UCSS filled with poor interfacial interaction. The result reveal that TCSS is a reinforcing filler that can be used for the production of natural rubber-based products for some engineering applications.","PeriodicalId":18881,"journal":{"name":"Nanotechnology, Science and Applications","volume":null,"pages":null},"PeriodicalIF":4.9,"publicationDate":"2021-12-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"86601524","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Synthesis of Polymeric (Self-Disappearing) Nano Medical Patches Loaded with a Long-Acting Pharmacological Substance by Electrospinning Method","authors":"Alia Hindi, Mohammad Yahia Masri, S. Hardcastle, M. Batal","doi":"10.33425/2639-9466.1029","DOIUrl":"https://doi.org/10.33425/2639-9466.1029","url":null,"abstract":"Nano-polymer (self-disappearing) medical patches loaded with a long-acting drug were manufactured by cospinning method of synthetic polymers PVA and PVP at a rate of 10%W for each polymer and with the addition different medicinal substances, namely diclofenac de ethylamine, gentamicin, in concentration 5%w (each substance separately). And studding the morphological structure of the prepared samples by scanning electron microscope (SEM) and X- Ray diffraction (XRD), then converted into a medical adhesive form, and then tested on the human hand directly, as it has proven its effectiveness in delivering the drug to the affected area directly. It is very easy to use, medically safe and economic, as it does not need huge industrial equipment for its production.","PeriodicalId":18881,"journal":{"name":"Nanotechnology, Science and Applications","volume":null,"pages":null},"PeriodicalIF":4.9,"publicationDate":"2021-12-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"79635998","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Nanomaterials and Rare Earths Used To Evaluate the Photocatalytic Degradation of a Dye, with Potential Use in Decontaminating Water Bodies","authors":"Naranjo-Castañeda Felix Antonio, Palacios-Grijalva Laura Nadxieli, Martínez-Jiménez Anatolio, Chávez-Sandoval Blanca Estela","doi":"10.33425/2639-9466.1026","DOIUrl":"https://doi.org/10.33425/2639-9466.1026","url":null,"abstract":"In this work, nanomaterials and rare earths were obtained with application in the degradation of dyes since in the developing countries the decontamination of water bodies is essential. We used TiO2 for incorporation of rare earths applied to photocatalytic activity in degradation of methyl blue due to its high chemical stability and corrosion resistance. We obtain nanostructured materials of TiO2, TiO2: Ln3+ (Ln3+ = Sm3+, Gd3+ and Yb3+) by sol gel method, for decontamination of dye such as methylene blue in surface water bodies. Through x-ray diffraction, we found that anatase-rutile phase was achieved in TiO2 and tetragonal anatase phase in TiO2 : Ln3+. Size average in nanometres of 31, 37, 44 y 34 for TiO2, TiO2 : Sm3+, TiO2: Gd3+ and TiO2:Yb3+ respectively determinate by atomic force microscopy and by UV spectroscopy the energy gap (2.94, 2.87, 2.85 and 2.95) eV respectively. As for the degradation of the methylene blue dye, the best catalyst under UV radiation was TiO2 : Gd3+ with 54% degradation compared to TiO2 that presented 52%, 29% for TiO2 : Sm3+ and with 27% to TiO2 : Yb3+ determined by fluorimetry. These materials must be applied in industrial post-treatment processes using photo catalysis for the decontamination of bodies of water.","PeriodicalId":18881,"journal":{"name":"Nanotechnology, Science and Applications","volume":null,"pages":null},"PeriodicalIF":4.9,"publicationDate":"2021-12-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"82581502","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Graphene Oxide as a Collagen Modifier of Amniotic Membrane and Burnt Skin.","authors":"Anna Pielesz,&nbsp;Czesław Ślusarczyk,&nbsp;Marta Sieradzka,&nbsp;Tomasz Kukulski,&nbsp;Dorota Biniaś,&nbsp;Ryszard Fryczkowski,&nbsp;Rafał Bobiński,&nbsp;Wioletta Waksmańska","doi":"10.2147/NSA.S343540","DOIUrl":"https://doi.org/10.2147/NSA.S343540","url":null,"abstract":"<p><strong>Introduction: </strong>The aim of this interdisciplinary study was to answer the question of whether active antioxidants as graphene oxide (GO), sodium ascorbate, and L-ascorbic acid modify at a molecular and supramolecular level the tissue of pathological amnion and the necrotic eschar degraded in thermal burn. We propose new solutions of modifiers based on GO that will become innovative ingredients to be used in transplants (amnion) and enhance regeneration of epidermis degraded in thermal burn.</p><p><strong>Methods: </strong>A Nicolet 6700 spectrophotometer with Omnic software and the EasiDiff diffusion accessory were used in FTIR spectroscopic analysis. A Nicolet Magna-IR 860 spectrometer with an FT Raman accessory was used to record the Raman spectra of the samples. The surface of the samples was examined using a Phenom ProX scanning electron microscope with an energy-dispersive X-ray spectroscopy detector to diagnose and illustrate morphological effects on skin and amnion samples. SAXS measurements were carried out with a compact Kratky camera equipped with the SWAXS optical system.</p><p><strong>Results: </strong>Characterisation of amide I-III regions, important for molecular structure, on both FTIR and FTR spectra revealed distinct shifts, testifying to organization of protein structure after GO modification. A wide lipid band associated with ester-group vibrations in phospholipids of cell membranes and vibrations of the carbonyl group of GO in the 1,790-1,720 cm^-1 band were observed in the spectra of thermally degraded and GO-modified epidermis and pathological amnion. SAXS studies revealed that GO caused a significant change in the structure of the burnt skin, but its influence on the structure of the amnion was weak.</p><p><strong>Conclusion: </strong>Modification of burn-damaged epidermis and pathological amnion by means of GO results in stabilization and regeneration of tissue at the level of molecular (FTIR, FTR) and supramolecular (SAXS) interactions.</p>","PeriodicalId":18881,"journal":{"name":"Nanotechnology, Science and Applications","volume":null,"pages":null},"PeriodicalIF":4.9,"publicationDate":"2021-12-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/1f/57/nsa-14-221.PMC8665888.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39727788","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Graphene and Graphene Oxide as a Support for Biomolecules in the Development of Biosensors.","authors":"Shiva Shahriari, Murali Sastry, Santosh Panjikar, R K Singh Raman","doi":"10.2147/NSA.S334487","DOIUrl":"10.2147/NSA.S334487","url":null,"abstract":"<p><p>Graphene and graphene oxide have become the base of many advanced biosensors due to their exceptional characteristics. However, lack of some properties, such as inertness of graphene in organic solutions and non-electrical conductivity of graphene oxide, are their drawbacks in sensing applications. To compensate for these shortcomings, various methods of modifications have been developed to provide the appropriate properties required for biosensing. Efficient modification of graphene and graphene oxide facilitates the interaction of biomolecules with their surface, and the ultimate bioconjugate can be employed as the main sensing part of the biosensors. Graphene nanomaterials as transducers increase the signal response in various sensing applications. Their large surface area and perfect biocompatibility with lots of biomolecules provide the prerequisite of a stable biosensor, which is the immobilization of bioreceptor on transducer. Biosensor development has paramount importance in the field of environmental monitoring, security, defense, food safety standards, clinical sector, marine sector, biomedicine, and drug discovery. Biosensor applications are also prevalent in the plant biology sector to find the missing links required in the metabolic process. In this review, the importance of oxygen functional groups in functionalizing the graphene and graphene oxide and different types of functionalization will be explained. Moreover, immobilization of biomolecules (such as protein, peptide, DNA, aptamer) on graphene and graphene oxide and at the end, the application of these biomaterials in biosensors with different transducing mechanisms will be discussed.</p>","PeriodicalId":18881,"journal":{"name":"Nanotechnology, Science and Applications","volume":null,"pages":null},"PeriodicalIF":4.9,"publicationDate":"2021-11-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/21/ce/nsa-14-197.PMC8605898.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39920141","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prospective Application of Nanoparticles Green Synthesized Using Medicinal Plant Extracts as Novel Nanomedicines.","authors":"Rajendran K Selvakesavan, Gregory Franklin","doi":"10.2147/NSA.S333467","DOIUrl":"10.2147/NSA.S333467","url":null,"abstract":"<p><p>The use of medicinal plants in green synthesis of metal nanoparticles is increasing day by day. A simple search for the keywords \"green synthesis\" and \"nanoparticles\" yields more than 33,000 articles in Scopus. As of August 10, 2021, more than 4000 articles have been published in 2021 alone. Besides demonstrating the ease and environmental-friendly route of synthesizing nanomaterials, many studies report the superior pharmacological properties of green synthesized nanoparticles compared to those synthesized by other methods. This is probably due to the fact that bioactive molecules are entrapped on the surface of these nanoparticles. On the other hand, recent studies have confirmed the nano-dimension and biocompatibility of metal ash (<i>Bhasma</i>) preparations, which are commonly macerated with biological products and administered for the treatment of various diseases in Indian medicine since ancient times. This perspective article argues for the prospective medical application of green nanoparticles in the light of <i>Bhasma</i>.</p>","PeriodicalId":18881,"journal":{"name":"Nanotechnology, Science and Applications","volume":null,"pages":null},"PeriodicalIF":4.9,"publicationDate":"2021-09-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/d6/1e/nsa-14-179.PMC8476107.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39470745","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}