The Impact of Surfactant Structures and High-Speed Mixing Dynamics in Achieving Nano-Sized Emulsions with Simple High-Speed Homogenization.

IF 4.9 Q2 NANOSCIENCE & NANOTECHNOLOGY
Nanotechnology, Science and Applications Pub Date : 2024-12-21 eCollection Date: 2024-01-01 DOI:10.2147/NSA.S492639
Sakdinon Na Nan, Jittima Amie Luckanagul, Vipaporn Rakkanka Panapisal
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引用次数: 0

Abstract

Purpose: This study investigates the impact of various mixing parameters and surfactant combinations on the physical characteristics of nanoemulsions produced using high-speed homogenization. Nanoemulsions are explored for their capacity to enhance transdermal drug delivery in pharmaceutical and cosmetic contexts.

Methods: Employing a standard high-speed homogenizer typical in the cosmetic industry, we tested different combinations of Polysorbate (Tween®) and Sorbitan ester (Span®) surfactants under single and intermittent process configurations. Key parameters assessed included particle size, size distribution, Oswald ripening, and creaming index.

Results: Nanoemulsions synthesized had particle sizes below 200 nm and appeared as white liquids with slight creaming. Extended mixing times were associated with smaller droplet sizes and reduced creaming. Both processing methods yielded similar nanoemulsion properties, indicating minimal impact from the type of process used. The nanoemulsions exhibited polydispersity indices ranging from 0.3 to 0.5, suggesting a uniform size distribution, and showed negligible Oswald ripening, which indicates stable droplet sizes over time.

Conclusion: The study confirms that precise control of mixing parameters and the selection of appropriate surfactant pairs are more critical than the choice of process in producing stable nanoemulsions. With efficient use of standard high-speed homogenizers, stable nanoemulsions suitable for large-scale production can be achieved, providing a cost-effective method for pharmaceutical and cosmetic industries.

表面活性剂结构和高速混合动力学对简单高速均质制备纳米乳液的影响。
目的:研究不同混合参数和表面活性剂组合对高速均质法制备纳米乳物理特性的影响。纳米乳剂在制药和化妆品领域增强经皮药物输送的能力。方法:采用化妆品行业典型的标准高速均质机,我们在单一和间歇工艺配置下测试了聚山梨酯(Tween®)和山梨酯(Span®)表面活性剂的不同组合。评估的关键参数包括粒径、粒径分布、奥斯瓦尔德成熟度和乳化指数。结果:合成的纳米乳剂粒径在200 nm以下,呈白色液体,有轻微的乳状。延长混合时间与更小的液滴尺寸和减少乳化有关。两种加工方法都产生了相似的纳米乳液性质,表明所使用的工艺类型对纳米乳液的影响最小。纳米乳液的多分散性指数在0.3 ~ 0.5之间,表明粒径分布均匀,奥斯瓦尔德成熟度可以忽略不计,表明随着时间的推移,液滴尺寸稳定。结论:精确控制混合参数和选择合适的表面活性剂对是制备稳定纳米乳的关键,而不是工艺的选择。通过高效使用标准高速均质机,可以获得适合大规模生产的稳定纳米乳液,为制药和化妆品行业提供了一种具有成本效益的方法。
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来源期刊
Nanotechnology, Science and Applications
Nanotechnology, Science and Applications NANOSCIENCE & NANOTECHNOLOGY-
CiteScore
11.70
自引率
0.00%
发文量
3
审稿时长
16 weeks
期刊介绍: Nanotechnology, Science and Applications is an international, peer-reviewed, Open Access journal that focuses on the science of nanotechnology in a wide range of industrial and academic applications. The journal is characterized by the rapid reporting of reviews, original research, and application studies across all sectors, including engineering, optics, bio-medicine, cosmetics, textiles, resource sustainability and science. Applied research into nano-materials, particles, nano-structures and fabrication, diagnostics and analytics, drug delivery and toxicology constitute the primary direction of the journal.
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