Mycobiology最新文献_第2页

Antifungal Activity of 3-Hydrazinoquinoxaline-2-Thiol, a Novel Quinoxaline Derivative against Candida Species. 新型喹喔啉衍生物 3-肼基喹喔啉-2-硫醇对白色念珠菌的抗真菌活性

IF 1.6 4区生物学

Mycobiology Pub Date : 2024-06-17 eCollection Date: 2024-01-01 DOI: 10.1080/12298093.2024.2362497

Abdelbagi Elfadil, Karem Ibrahem

{"title":"Antifungal Activity of 3-Hydrazinoquinoxaline-2-Thiol, a Novel Quinoxaline Derivative against Candida Species.","authors":"Abdelbagi Elfadil, Karem Ibrahem","doi":"10.1080/12298093.2024.2362497","DOIUrl":"10.1080/12298093.2024.2362497","url":null,"abstract":"Candida ranks as among the most frequently encountered fungal infections that associated with high morbidity and mortality. Quinoxaline derivatives are a group of small molecules that showed a promising antimicrobial activity. This study aimed to investigate the fungicidal effects of 3-hydrazinoquinoxaline-2-thiol against Candida in comparison with Amphotericin B in vitro as a reference. Also, we aim to assess the efficacy of 3-hydrazinoquinoxaline-2-thiol in vivo using mice oral candidiasis model. Fifty-six Candida isolates were subjected to susceptibility testing by broth microdilution method for 3-hydrazinoquinoxaline-2-thiol and Amphotericin B. Therefore, Minimal inhibitory concentrations (MIC) were assessed and compared. The oral candidiasis mice model was used to evaluate the activity of 3-hydrazinoquinoxaline-2-thiol in vivo. Microbiological evaluation of progression and ELISA were used in this study. 3-hydrazinoquinoxaline-2-thiol was more effective than Amphotericin B against most clinical isolates of Candida albicans. Higher effectiveness was seen against Candida glabrata and Candida parapsilosis isolates. However, the efficiency against Candida tropicalis isolates varies. 3-hydrazinoquinoxaline-2-thiol was also effective against Pichia kudriavzevii and Clavispora lusitaniae. 3-hydrazinoquinoxaline-2-thiol showed a good efficacy in mice model against C. albicans cells ATCC 10231. 3-hydrazinoquinoxaline-2-thiol has shown promising antifungal and anti-inflammatory activity against different Candida species. More tests and experiments are needed.","PeriodicalId":18825,"journal":{"name":"Mycobiology","volume":null,"pages":null},"PeriodicalIF":1.6,"publicationDate":"2024-06-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11210417/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141469588","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Inoculants of Arbuscular Mycorrhizal Fungi Influence Growth and Biomass of Terminalia arjuna under Amendment and Anamendment Entisol. 丛枝菌根真菌接种剂在改良和无改良 Entisol 条件下对旱金莲生长和生物量的影响

IF 1.6 4区生物学

Mycobiology Pub Date : 2024-06-17 eCollection Date: 2024-01-01 DOI: 10.1080/12298093.2024.2360750

Atul Kumar Bhardwaj, K K Chandra, Rajesh Kumar

{"title":"Inoculants of Arbuscular Mycorrhizal Fungi Influence Growth and Biomass of Terminalia arjuna under Amendment and Anamendment Entisol.","authors":"Atul Kumar Bhardwaj, K K Chandra, Rajesh Kumar","doi":"10.1080/12298093.2024.2360750","DOIUrl":"10.1080/12298093.2024.2360750","url":null,"abstract":"Entisol soil is hard and compact in nature, rendering it high in bulk density, which influences root penetration adversely and thereby poor plant growth. In this experiment, used seven treatments in different combination in normal soil, were used as growth media for the Terminalia arjuna seedling. T3 (60% entisol) found the best as it gave the highest biomass in the species regardless of arbuscular mycorrhizal fungi (AMF) treatment. AMF treatment enhanced the growth and biomass of plants significantly in all the given treatments. AMF colonization observed a maximum in tertiary roots. T1 (100% entisol soil) exhibited the highest degree of AMF colonization in tertiary roots, resulting in the highest mycorrhiza dependency of plants for this soil. The addition of normal soil to entisol soil was found to decrease the bulk density, resulting in increased root diameter, and T3 plants exhibited the highest biomass and AMF compatibility for T. arjuna species. The T. arjuna plant's growth and biomass responded positively to AMF in all types of treatments. The plant's growth and biomass were highest in the T3 treatment, which had a bulk density of 1.50 g/cm3. In this study, we combined the entisol with mycorrhizal inoculation of the nursery growing medium to promote plant growth and biomass, improve the plant's ability to hold water and absorb nutrients, and lower the entisol's bulk density. The T. arjuna (Roxb) plant responds very favorably to mycorrhiza inoculation in nursery conditions with the entisol growth medium.","PeriodicalId":18825,"journal":{"name":"Mycobiology","volume":null,"pages":null},"PeriodicalIF":1.6,"publicationDate":"2024-06-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11210415/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141469590","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Effects of Black and White Mulch on Mycelial Growth of Tuber Species in Korean Field Environment 黑白覆盖物对韩国田间环境中块茎物种菌丝生长的影响

IF 1.9 4区生物学

Mycobiology Pub Date : 2024-06-12 DOI: 10.1080/12298093.2024.2360748

Jung-Min Lee, Ahn-Heum Eom