Microsystems & Nanoengineering最新文献_第9页

Correction: A tactile and airflow motion sensor based on flexible double-layer magnetic cilia. 更正：基于柔性双层磁性纤毛的触觉和气流运动传感器

IF 7.3 1区工程技术

Microsystems & Nanoengineering Pub Date : 2024-06-24 eCollection Date: 2024-01-01 DOI: 10.1038/s41378-024-00710-8

Jiandong Man, Junjie Zhang, Guangyuan Chen, Ning Xue, Jiamin Chen

引用次数: 0

Monolithic integrated optoelectronic chip for vector force detection. 用于矢量力检测的单片集成光电芯片。

IF 7.3 1区工程技术

Microsystems & Nanoengineering Pub Date : 2024-06-24 eCollection Date: 2024-01-01 DOI: 10.1038/s41378-024-00712-6

Jiansong Feng, Zhongqi Wang, Mengyuan Zhanghu, Xu Zhang, Yong Shen, Jing Yang, Zhibin Li, Bin Chen, Taihong Wang, Xiaolong Chen, Zhaojun Liu

{"title":"Monolithic integrated optoelectronic chip for vector force detection.","authors":"Jiansong Feng, Zhongqi Wang, Mengyuan Zhanghu, Xu Zhang, Yong Shen, Jing Yang, Zhibin Li, Bin Chen, Taihong Wang, Xiaolong Chen, Zhaojun Liu","doi":"10.1038/s41378-024-00712-6","DOIUrl":"10.1038/s41378-024-00712-6","url":null,"abstract":"Sensors with a small footprint and real-time detection capabilities are crucial in robotic surgery and smart wearable equipment. Reducing device footprint while maintaining its high performance is a major challenge and a significant limitation to their development. Here, we proposed a monolithic integrated micro-scale sensor, which can be used for vector force detection. This sensor combines an optical source, four photodetectors, and a hemispherical silicone elastomer component on the same sapphire-based AlGaInP wafer. The chip-scale optical coupling is achieved by employing the laser lift-off techniques and the flip-chip bonding to a processed sapphire substrate. This hemispherical structure device can detect normal and shear forces as low as 1 mN within a measurement range of 0-220 mN for normal force and 0-15 mN for shear force. After packaging, the sensor is capable of detecting forces over a broader range, with measurement capabilities extending up to 10 N for normal forces and 0.2 N for shear forces. It has an accuracy of detecting a minimum normal force of 25 mN and a minimum shear force of 20 mN. Furthermore, this sensor has been validated to have a compact footprint of approximately 1.5 mm2, while maintaining high real-time response. We also demonstrate its promising potential by combining this sensor with fine surface texture perception in the fields of compact medical robot interaction and wearable devices.","PeriodicalId":18560,"journal":{"name":"Microsystems & Nanoengineering","volume":null,"pages":null},"PeriodicalIF":7.3,"publicationDate":"2024-06-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11194277/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141446547","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

An acoustofluidic device for the automated separation of platelet-reduced plasma from whole blood. 从全血中自动分离血小板还原血浆的声流体设备。

IF 7.3 1区工程技术

Microsystems & Nanoengineering Pub Date : 2024-06-24 eCollection Date: 2024-01-01 DOI: 10.1038/s41378-024-00707-3

Zhehan Ma, Jianping Xia, Neil Upreti, Emeraghi David, Joseph Rufo, Yuyang Gu, Kaichun Yang, Shujie Yang, Xiangchen Xu, Jean Kwun, Eileen Chambers, Tony Jun Huang

{"title":"An acoustofluidic device for the automated separation of platelet-reduced plasma from whole blood.","authors":"Zhehan Ma, Jianping Xia, Neil Upreti, Emeraghi David, Joseph Rufo, Yuyang Gu, Kaichun Yang, Shujie Yang, Xiangchen Xu, Jean Kwun, Eileen Chambers, Tony Jun Huang","doi":"10.1038/s41378-024-00707-3","DOIUrl":"10.1038/s41378-024-00707-3","url":null,"abstract":"Separating plasma from whole blood is an important sample processing technique required for fundamental biomedical research, medical diagnostics, and therapeutic applications. Traditional protocols for plasma isolation require multiple centrifugation steps or multiunit microfluidic processing to sequentially remove large red blood cells (RBCs) and white blood cells (WBCs), followed by the removal of small platelets. Here, we present an acoustofluidic platform capable of efficiently removing RBCs, WBCs, and platelets from whole blood in a single step. By leveraging differences in the acoustic impedances of fluids, our device generates significantly greater forces on suspended particles than conventional microfluidic approaches, enabling the removal of both large blood cells and smaller platelets in a single unit. As a result, undiluted human whole blood can be processed by our device to remove both blood cells and platelets (>90%) at low voltages (25 Vpp). The ability to successfully remove blood cells and platelets from plasma without altering the properties of the proteins and antibodies present creates numerous potential applications for our platform in biomedical research, as well as plasma-based diagnostics and therapeutics. Furthermore, the microfluidic nature of our device offers advantages such as portability, cost efficiency, and the ability to process small-volume samples.","PeriodicalId":18560,"journal":{"name":"Microsystems & Nanoengineering","volume":null,"pages":null},"PeriodicalIF":7.3,"publicationDate":"2024-06-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11194281/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141446496","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Internal flow in sessile droplets induced by substrate oscillation: towards enhanced mixing and mass transfer in microfluidic systems. 基底振荡诱导的无柄液滴内部流动：实现微流体系统中更强的混合和传质。

IF 7.3 1区工程技术

Microsystems & Nanoengineering Pub Date : 2024-06-24 eCollection Date: 2024-01-01 DOI: 10.1038/s41378-024-00714-4

Tianyi Zhang, Peng Zhou, Terrence Simon, Tianhong Cui

{"title":"Internal flow in sessile droplets induced by substrate oscillation: towards enhanced mixing and mass transfer in microfluidic systems.","authors":"Tianyi Zhang, Peng Zhou, Terrence Simon, Tianhong Cui","doi":"10.1038/s41378-024-00714-4","DOIUrl":"10.1038/s41378-024-00714-4","url":null,"abstract":"The introduction of flows within sessile droplets is highly effective for many lab-on-a-chip chemical and biomedical applications. However, generating such flows is difficult due to the typically small droplet volumes. Here, we present a simple, non-contact strategy to generate internal flows in sessile droplets for enhancing mixing and mass transport. The flows are driven by actuating a rigid substrate into oscillation with certain amplitude distributions without relying on the resonance of the droplet itself. Substrate oscillation characteristics and corresponding flow patterns are documented herein. Mixing indices and mass transfer coefficients of sessile droplets on the substrate surface are measured using optical and electrochemical methods. They demonstrate complete mixing within the droplets in 1.35 s and increases in mass transfer rates of more than seven times static values. Proof of concept was conducted with experiments of silver nanoparticle synthesis and with heavy metal ion sensing employing the sessile droplet as a microreactor for synthesis and an electrochemical cell for sensing. The degrees of enhancement of synthesis efficiency and detection sensitivity attributed to the internal flows are experimentally documented.","PeriodicalId":18560,"journal":{"name":"Microsystems & Nanoengineering","volume":null,"pages":null},"PeriodicalIF":7.3,"publicationDate":"2024-06-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11196738/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141452707","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

MEMS reservoir computing system with stiffness modulation for multi-scene data processing at the edge. 具有刚度调节功能的 MEMS 水库计算系统，用于边缘多场景数据处理。

IF 7.3 1区工程技术

Microsystems & Nanoengineering Pub Date : 2024-06-24 eCollection Date: 2024-01-01 DOI: 10.1038/s41378-024-00701-9

Xiaowei Guo, Wuhao Yang, Xingyin Xiong, Zheng Wang, Xudong Zou

{"title":"MEMS reservoir computing system with stiffness modulation for multi-scene data processing at the edge.","authors":"Xiaowei Guo, Wuhao Yang, Xingyin Xiong, Zheng Wang, Xudong Zou","doi":"10.1038/s41378-024-00701-9","DOIUrl":"10.1038/s41378-024-00701-9","url":null,"abstract":"Reservoir computing (RC) is a bio-inspired neural network structure which can be implemented in hardware with ease. It has been applied across various fields such as memristors, and electrochemical reactions, among which the micro-electro-mechanical systems (MEMS) is supposed to be the closest to sensing and computing integration. While previous MEMS RCs have demonstrated their potential as reservoirs, the amplitude modulation mode was found to be inadequate for computing directly upon sensing. To achieve this objective, this paper introduces a novel MEMS reservoir computing system based on stiffness modulation, where natural signals directly influence the system stiffness as input. Under this innovative concept, information can be processed locally without the need for advanced data collection and pre-processing. We present an integrated RC system characterized by small volume and low power consumption, eliminating complicated setups in traditional MEMS RC for data discretization and transduction. Both simulation and experiment were conducted on our accelerometer. We performed nonlinearity tuning for the resonator and optimized the post-processing algorithm by introducing a digital mask operator. Consequently, our MEMS RC is capable of both classification and forecasting, surpassing the capabilities of our previous non-delay-based architecture. Our method successfully processed word classification, with a 99.8% accuracy, and chaos forecasting, with a 0.0305 normalized mean square error (NMSE), demonstrating its adaptability for multi-scene data processing. This work is essential as it presents a novel MEMS RC with stiffness modulation, offering a simplified, efficient approach to integrate sensing and computing. Our approach has initiated edge computing, enabling emergent applications in MEMS for local computations.","PeriodicalId":18560,"journal":{"name":"Microsystems & Nanoengineering","volume":null,"pages":null},"PeriodicalIF":7.3,"publicationDate":"2024-06-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11194282/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141446546","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Graphene photodetectors integrated with silicon and perovskite quantum dots. 集成了硅和过氧化物量子点的石墨烯光电探测器。

IF 7.3 1区工程技术

Microsystems & Nanoengineering Pub Date : 2024-06-20 eCollection Date: 2024-01-01 DOI: 10.1038/s41378-024-00722-4

Kashif Abbas, Peirui Ji, Naveed Ullah, Shareen Shafique, Ze Zhang, Muhammad Faizan Ameer, Shenghan Qin, Shuming Yang

引用次数: 0

Stable diffusion gradients in microfluidic conduits bounded by fluid walls. 以流体壁为界的微流体导管中的稳定扩散梯度

IF 7.3 1区工程技术

Microsystems & Nanoengineering Pub Date : 2024-06-20 eCollection Date: 2024-01-01 DOI: 10.1038/s41378-024-00698-1

Federico Nebuloni, Cyril Deroy, Peter R Cook, Edmond J Walsh

{"title":"Stable diffusion gradients in microfluidic conduits bounded by fluid walls.","authors":"Federico Nebuloni, Cyril Deroy, Peter R Cook, Edmond J Walsh","doi":"10.1038/s41378-024-00698-1","DOIUrl":"10.1038/s41378-024-00698-1","url":null,"abstract":"Assays mimicking in vitro the concentration gradients triggering biological responses like those involved in fighting infections and blood clotting are essential for biomedical research. Microfluidic assays prove especially attractive as they allow precise control of gradient shape allied to a reduction in scale. Conventional microfluidic devices are fabricated using solid plastics that prevent direct access to responding cells. Fluid-walled microfluidics allows the manufacture of circuits on standard Petri dishes in seconds, coupled to simple operating methods; cell-culture medium sitting in a standard dish is confined to circuits by fluid walls made of an immiscible fluorocarbon. We develop and experimentally validate an analytical model of diffusion between two or more aqueous streams flowing at different rates into a fluid-walled conduit with the cross-section of a circular segment. Unlike solid walls, fluid walls morph during flows as pressures fall, with wall shape changing down the conduit. The model is validated experimentally for Fourier numbers < 0.1 using fluorescein diffusing between laminar streams. It enables a priori prediction of concentration gradients throughout a conduit, so allowing rapid circuit design as well as providing bio-scientists with an accurate way of predicting local concentrations of bioactive molecules around responsive and non-responsive cells.","PeriodicalId":18560,"journal":{"name":"Microsystems & Nanoengineering","volume":null,"pages":null},"PeriodicalIF":7.3,"publicationDate":"2024-06-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11189932/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141443069","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Organic-inorganic hybrid piezotronic bipolar junction transistor for pressure sensing. 用于压力传感的有机-无机混合压电双极结晶体管。

IF 7.3 1区工程技术

Microsystems & Nanoengineering Pub Date : 2024-06-20 eCollection Date: 2024-01-01 DOI: 10.1038/s41378-024-00699-0

Emad Iranmanesh, Zihao Liang, Weiwei Li, Congwei Liao, Shunyu Jin, Chuan Liu, Kai Wang, Shengdong Zhang, Charalampos Doumanidis, Gehan A J Amaratunga, Hang Zhou

{"title":"Organic-inorganic hybrid piezotronic bipolar junction transistor for pressure sensing.","authors":"Emad Iranmanesh, Zihao Liang, Weiwei Li, Congwei Liao, Shunyu Jin, Chuan Liu, Kai Wang, Shengdong Zhang, Charalampos Doumanidis, Gehan A J Amaratunga, Hang Zhou","doi":"10.1038/s41378-024-00699-0","DOIUrl":"10.1038/s41378-024-00699-0","url":null,"abstract":"With the rapid development of the Internet of Things (IoTs), wearable sensors are playing an increasingly important role in daily monitoring of personal health and wellness. The signal-to-noise-ratio has become the most critical performance factor to consider. To enhance it, on the one hand, good sensing materials/devices have been employed; on the other hand, signal amplification and noise reduction circuits have been used. However, most of these devices and circuits work in an active sampling mode, requiring frequent data acquisition and hence, entailing high-power consumption. In this scenario, a flexible and wearable event-triggered sensor with embedded signal amplification without an external power supply is of great interest. Here, we report a flexible two-terminal piezotronic n-p-n bipolar junction transistor (PBJT) that acts as an autonomous and highly sensitive, current- and/or voltage-mediated pressure sensor. The PBJT is formed by two back-to-back piezotronic diodes which are defined as emitter-base and collector-base diodes. Upon force exertion on the emitter side, as a result of the piezoelectric effect, the emitter-base diode is forward biased while the collector-base diode is reverse biased. Due to the inherent BJT amplification effect, the PBJT achieves record-high sensitivities of 139.7 kPa-1 (current-based) and 88.66 kPa-1 (voltage-based) in sensing mode. The PBJT also has a fast response time of <110 ms under exertion of dynamic stimuli ranging from a flying butterfly to a gentle finger touch. Therefore, the PBJT advances the state of the art not only in terms of sensitivity but also in regard to being self-driven and autonomous, making it promising for pressure sensing and other IoT applications.","PeriodicalId":18560,"journal":{"name":"Microsystems & Nanoengineering","volume":null,"pages":null},"PeriodicalIF":7.3,"publicationDate":"2024-06-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11189938/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141443068","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Optically levitated micro gyroscopes with an MHz rotational vaterite rotor 带 MHz 旋转瓦特石转子的光悬浮微型陀螺仪

IF 7.9 1区工程技术

Microsystems & Nanoengineering Pub Date : 2024-06-18 DOI: 10.1038/s41378-024-00726-0

Kai Zeng, Xiangming Xu, Yulie Wu, Xuezhong Wu, D. Xiao

引用次数: 0

Wearable multichannel-active pressurized pulse sensing platform. 可穿戴式多通道主动加压脉冲传感平台。

IF 7.9 1区工程技术

Microsystems & Nanoengineering Pub Date : 2024-06-11 eCollection Date: 2024-01-01 DOI: 10.1038/s41378-024-00703-7

Yunlong Zhao, Qingxia Sun, Shixuan Mei, Libo Gao, Xikuan Zhang, Zekun Yang, Xueli Nan, Haiyan Zhang, Chenyang Xue, Junyang Li

{"title":"Wearable multichannel-active pressurized pulse sensing platform.","authors":"Yunlong Zhao, Qingxia Sun, Shixuan Mei, Libo Gao, Xikuan Zhang, Zekun Yang, Xueli Nan, Haiyan Zhang, Chenyang Xue, Junyang Li","doi":"10.1038/s41378-024-00703-7","DOIUrl":"10.1038/s41378-024-00703-7","url":null,"abstract":"With the modernization of traditional Chinese medicine (TCM), creating devices to digitalize aspects of pulse diagnosis has proved to be challenging. The currently available pulse detection devices usually rely on external pressure devices, which are either bulky or poorly integrated, hindering their practical application. In this work, we propose an innovative wearable active pressure three-channel pulse monitoring device based on TCM pulse diagnosis methods. It combines a flexible pressure sensor array, flexible airbag array, active pressure control unit, advanced machine learning approach, and a companion mobile application for human-computer interaction. Due to the high sensitivity (460.1 kPa-1), high linearity (R 2 > 0.999) and flexibility of the flexible pressure sensors, the device can accurately simulate finger pressure to collect pulse waves (Cun, Guan, and Chi) at different external pressures on the wrist. In addition, by measuring the change in pulse wave amplitude at different pressures, an individual's blood pressure status can be successfully predicted. This enables truly wearable, actively pressurized, continuous wireless dynamic monitoring of wrist pulse health. The innovative and integrated design of this pulse monitoring platform could provide a new paradigm for digitizing aspects of TCM and other smart healthcare systems.","PeriodicalId":18560,"journal":{"name":"Microsystems & Nanoengineering","volume":null,"pages":null},"PeriodicalIF":7.9,"publicationDate":"2024-06-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11166975/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141311103","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0