Microfluidic contact lens: fabrication approaches and applications.

IF 7.3 1区 工程技术 Q1 INSTRUMENTS & INSTRUMENTATION
Aravind M, Ankur Saxena, Dhaneshwar Mishra, Kulwant Singh, Sajan D George
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引用次数: 0

Abstract

Microfluidic contact lenses integrate microscale features that can efficiently and precisely manipulate, interact, and analyze the small volumes of tears available in the limited accessible space for the lens in the eye. The microfluidic network on contact lenses allows the miniaturization of biochemical operations on the wealth of physiological information available in the eye. Sensors integrated into channels enable real-time monitoring of ocular parameters, including glucose, pH, electrolytes, or other biomarkers. Additionally, microchannel-integrated contact lenses have demonstrated potential as power-free, continuous intraocular pressure monitoring platforms for the effective management of glaucoma. Furthermore, the controlled release of medications directly onto the eye from microfluidic contact lenses enhances therapeutic efficacy by increasing bioavailability. Despite current challenges such as scalable fabrication techniques, microfluidic contact lenses hold immense promise for ocular health, bridging the gap between diagnostics and treatment. This review summarizes the progress made in the design and fabrication of microfluidic contact lenses, with a special emphasis on the methods adopted to fabricate microfluidic contact lenses. Furthermore, the various applications of microfluidic contact lenses, ocular disease diagnosis, and drug delivery in particular are discussed in detail. Aside from outlining the state-of-the-art research activities in this area, challenges and future directions are discussed here.

微流体隐形眼镜集成了微尺度功能,可在眼内镜片有限的可接触空间内高效、精确地操作、交互和分析少量泪液。通过隐形眼镜上的微流体网络,可以对眼球中的大量生理信息进行微型生化操作。集成在通道中的传感器可以实时监测眼部参数,包括葡萄糖、pH 值、电解质或其他生物标记物。此外,集成了微通道的隐形眼镜已证明具有作为无电源、持续眼压监测平台的潜力,可有效控制青光眼。此外,从微流体接触镜中直接向眼睛控制释放药物,可提高生物利用率,从而增强疗效。尽管目前存在可扩展的制造技术等挑战,但微流控接触镜在眼部健康方面前景广阔,是诊断和治疗之间的桥梁。本综述总结了微流控隐形眼镜设计和制造方面取得的进展,特别强调了制造微流控隐形眼镜所采用的方法。此外,还详细讨论了微流控隐形眼镜的各种应用、眼部疾病诊断,特别是药物输送。除了概述该领域的最新研究活动外,还讨论了面临的挑战和未来的发展方向。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Microsystems & Nanoengineering
Microsystems & Nanoengineering Materials Science-Materials Science (miscellaneous)
CiteScore
12.00
自引率
3.80%
发文量
123
审稿时长
20 weeks
期刊介绍: Microsystems & Nanoengineering is a comprehensive online journal that focuses on the field of Micro and Nano Electro Mechanical Systems (MEMS and NEMS). It provides a platform for researchers to share their original research findings and review articles in this area. The journal covers a wide range of topics, from fundamental research to practical applications. Published by Springer Nature, in collaboration with the Aerospace Information Research Institute, Chinese Academy of Sciences, and with the support of the State Key Laboratory of Transducer Technology, it is an esteemed publication in the field. As an open access journal, it offers free access to its content, allowing readers from around the world to benefit from the latest developments in MEMS and NEMS.
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