Microsystems & Nanoengineering最新文献_第3页

A wearable self-aid microneedle chip based on actively transdermal delivery of epinephrine. 一种基于肾上腺素主动透皮输送的可穿戴自助微针芯片。

IF 7.3 1区工程技术

Microsystems & Nanoengineering Pub Date : 2025-05-16 DOI: 10.1038/s41378-025-00941-3

Chenxi Jin, Peng Guo, Wenjun Li, Wangwang Zhu, Chengcheng Li, Jing Ma, Jun Li, Dachao Li, Jing He, Zhihua Pu

{"title":"A wearable self-aid microneedle chip based on actively transdermal delivery of epinephrine.","authors":"Chenxi Jin, Peng Guo, Wenjun Li, Wangwang Zhu, Chengcheng Li, Jing Ma, Jun Li, Dachao Li, Jing He, Zhihua Pu","doi":"10.1038/s41378-025-00941-3","DOIUrl":"10.1038/s41378-025-00941-3","url":null,"abstract":"Epinephrine is important for first aid and usually applied via injection, which is painful and problematic in operation, thereby making it difficult to self-delivery. In this study, a method to actively transdermal delivery of epinephrine is proposed based on incorporating microneedles with iontophoresis, and then a wearable device is fabricated for rapid and controllable self-delivery of epinephrine. The device consists of a hydrogel microneedle array, a conductive drug delivery hydrogel, iontophoresis electrodes, and an encapsulated cartridge with a spring and self-locking micro-mechanism. The microneedles create subcutaneous microchannels, allowing the epinephrine contained in the hydrogel to enter the body under the control of iontophoretic currents. The dosage and rate can be adjusted at different levels by pressing the button so that it can be used by different groups of people for rapid self-aid and recovery from fatigue. The device can be worn in advance if required. In-vitro tests showed that the transdermal delivery rate of the device was between 0.02642 and 0.1059 mg/h cm². As a proof-of-concept application, in-vivo experiments showed that the device could reverse life-threatening shock reactions in a piglet model of hemorrhagic shock through the delivery of epinephrine.","PeriodicalId":18560,"journal":{"name":"Microsystems & Nanoengineering","volume":"11 1","pages":"92"},"PeriodicalIF":7.3,"publicationDate":"2025-05-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12084290/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144086447","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Direct extraction of respiratory information from pulse waves using a finger-inspired flexible pressure sensor system. 直接提取呼吸信息从脉搏波使用手指启发柔性压力传感器系统。

IF 7.3 1区工程技术

Microsystems & Nanoengineering Pub Date : 2025-05-16 DOI: 10.1038/s41378-025-00924-4

Xikuan Zhang, Jin Chai, Lingxiao Xu, Shixuan Mei, Xin Wang, Yunlong Zhao, Chenyang Xue, Yongjun Wang, Danfeng Cui, Zengxing Zhang, Haiyan Zhang, Libo Gao

{"title":"Direct extraction of respiratory information from pulse waves using a finger-inspired flexible pressure sensor system.","authors":"Xikuan Zhang, Jin Chai, Lingxiao Xu, Shixuan Mei, Xin Wang, Yunlong Zhao, Chenyang Xue, Yongjun Wang, Danfeng Cui, Zengxing Zhang, Haiyan Zhang, Libo Gao","doi":"10.1038/s41378-025-00924-4","DOIUrl":"10.1038/s41378-025-00924-4","url":null,"abstract":"The long-term monitoring of respiratory status is crucial for the prevention and diagnosis of respiratory diseases. However, existing continuous respiratory monitoring devices are typically bulky and require either chest strapping or proximity to the nasal area, which compromises user comfort and may disrupt the monitoring process. To overcome these challenges, we have developed a flexible, attachable, lightweight, and miniaturized system designed for extended wear on the wrist. This system incorporates signal acquisition circuitry, a mobile client, and a deep neural network, facilitating long-term respiratory monitoring. Specifically, we fabricated a highly sensitive (11,847.24 kPa-1) flexible pressure sensor using a screen printing process, which is capable of functioning beyond 70,000 cycles. Additionally, we engineered a bidirectional long short-term memory (BiLSTM) neural network, enhanced with a residual module, to classify various respiratory states including slow, normal, fast, and simulated breathing. The system achieved a dataset classification accuracy exceeding 99.5%. We have successfully demonstrated a stable, cost-effective, and durable respiratory sensor system that can quantitatively collect and store respiratory data for individuals and groups. This system holds potential for everyday monitoring of physiological signals and healthcare applications.","PeriodicalId":18560,"journal":{"name":"Microsystems & Nanoengineering","volume":"11 1","pages":"90"},"PeriodicalIF":7.3,"publicationDate":"2025-05-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12084401/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144086462","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Nanojet visualization and dark-field imaging of optically trapped vaterite capsules with endoscopic illumination. 内窥镜照明下光捕获水晶石胶囊的纳米射流可视化和暗场成像。

IF 7.3 1区工程技术

Microsystems & Nanoengineering Pub Date : 2025-05-16 DOI: 10.1038/s41378-025-00951-1

Andrei Ushkov, Andrey Machnev, Denis Kolchanov, Toms Salgals, Janis Alnis, Vjaceslavs Bobrovs, Pavel Ginzburg

{"title":"Nanojet visualization and dark-field imaging of optically trapped vaterite capsules with endoscopic illumination.","authors":"Andrei Ushkov, Andrey Machnev, Denis Kolchanov, Toms Salgals, Janis Alnis, Vjaceslavs Bobrovs, Pavel Ginzburg","doi":"10.1038/s41378-025-00951-1","DOIUrl":"10.1038/s41378-025-00951-1","url":null,"abstract":"Optical responsivity grants biomedical capsules additional capabilities, promoting them towards multifunctional theragnostic nanodevices. In this endeavor, screening candidates under conditions that closely resemble in situ environments is crucial for both the initial optimization and the subsequent inspection stages of development and operation. Optical tweezers equipped with dark-field spectroscopy are among the preferable tools for nanoparticle imaging and refractometry. However, the effectiveness of conventional illumination and light collection arrangements for inspecting anisotropic complex inner composition particles is quite limited due to reduced collection angles, which can result in the omission of features in scattering diagrams. Here we introduce an endoscopic dark-field illumination scheme, where light is launched on an optically trapped particle from a single-mode fiber, immersed into a fluid cell. This arrangement disentangles illumination and collection paths, thus allowing the collection of scattered light with a very high numerical aperture. This methodology is applied to vaterite capsules, which are known to possess strong anisotropic responses. Tweezer configuration allows revealing optical properties for different crystallographic orientations of vaterite, which is complex to do otherwise. Furthermore, endoscopic dark-field images reveal the emergence of polarization-dependent long-range photonic nanojets, which are capable of interacting with nearby particles, demonstrating a new pathway for nanojet image formation.","PeriodicalId":18560,"journal":{"name":"Microsystems & Nanoengineering","volume":"11 1","pages":"91"},"PeriodicalIF":7.3,"publicationDate":"2025-05-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12084533/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144086465","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Combining time domain modulation optofluidics and high dynamic range imaging for multiplexed, high throughput digital droplet assays. 结合时域调制光流体和多路、高通量数字液滴分析的高动态范围成像。

IF 7.3 1区工程技术

Microsystems & Nanoengineering Pub Date : 2025-05-16 DOI: 10.1038/s41378-025-00918-2

Yasemin Atiyas, Michael J Siedlik, Stephanie J Yang, David A Issadore

{"title":"Combining time domain modulation optofluidics and high dynamic range imaging for multiplexed, high throughput digital droplet assays.","authors":"Yasemin Atiyas, Michael J Siedlik, Stephanie J Yang, David A Issadore","doi":"10.1038/s41378-025-00918-2","DOIUrl":"10.1038/s41378-025-00918-2","url":null,"abstract":"Digital enzyme-linked immunoassays (dELISA) have been successfully applied to the ultrasensitive quantification of analytes, including nucleic acids, proteins, cells, and extracellular vesicles, achieving robust detection limits in complex clinical specimens such as blood, and demonstrating utility across a broad range of clinical applications. The ultrasensitivity of dELISA comes from partitioning single analytes, captured onto a microbead, into millions of compartments so that they can be counted individually. There is particular interest in using dELISA for multiplexed measurements, but generating and detecting the billions of compartments necessary to perform multiplexed ultrasensitive dELISA remains a challenge. To address this, we have developed a high-throughput, optofluidic platform that performs quantitative fluorescence measurements on five populations of microbeads, each encoded with distinct ratios of two fluorescent dyes, for digital assays. The key innovation of our work is the parallelization of droplet generation and detection, combined with time-domain encoding of the excitation sources into distinct patterns that barcode the emission signal of both dyes within each bead, achieving high throughput (6 × 106 droplets/min) and accurate readout. Additionally, we modulate the exposure settings of the digital camera, capturing images of multiplexed beads and the droplet fluorescent substrate in consecutive frames, a method inspired by high dynamic range (HDR) photography. Our platform accurately classifies five populations of dual-encoded beads (accuracy > 99%) and detects bead-bound streptavidin-horseradish peroxidase molecules in a third fluorescence channel. This work establishes the technological foundation to combine high multiplexing and high throughput for droplet digital assays.","PeriodicalId":18560,"journal":{"name":"Microsystems & Nanoengineering","volume":"11 1","pages":"93"},"PeriodicalIF":7.3,"publicationDate":"2025-05-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12084528/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144086450","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

An eighteen-organ microphysiological system coupling a vascular network and excretion system for drug discovery. 一个由18个器官组成的微生理系统，连接血管网络和排泄系统，用于药物发现。

IF 7.3 1区工程技术

Microsystems & Nanoengineering Pub Date : 2025-05-14 DOI: 10.1038/s41378-025-00933-3

Jing Wang, Huixue Zhang, Yueyang Qu, Yang Yang, Shuhui Xu, Zhenni Ji, Yuxiu Wang, Xiuli Zhang, Yong Luo

{"title":"An eighteen-organ microphysiological system coupling a vascular network and excretion system for drug discovery.","authors":"Jing Wang, Huixue Zhang, Yueyang Qu, Yang Yang, Shuhui Xu, Zhenni Ji, Yuxiu Wang, Xiuli Zhang, Yong Luo","doi":"10.1038/s41378-025-00933-3","DOIUrl":"https://doi.org/10.1038/s41378-025-00933-3","url":null,"abstract":"Physiological supporting systems, such as the vascular network and excretion system, are crucial for the effective functioning of organs. This study demonstrates that when a body-on-a-chip microdevice is coupled with miniaturized physiological support systems, it can create a multi-organ microphysiological system capable of more accurately mimicking the physiological complexity of a body, thereby offering potential for preclinical drug testing. To exemplify this concept, we have developed a model system comprising 18 types of microtissues interconnected by a vascular network that replicates the in vivo blood distribution among the organs. Furthermore, this system includes an excretory system with a micro-stirrer that ensures elimination efficiency akin to in vivo conditions. Our findings indicate that this system can: (1) survive and function for almost two months; (2) achieve two-compartment pharmacokinetics of a drug; (3) investigate the dynamic relationship between the tissue distribution and toxicity of a drug; (4) establish the multimorbidity model and evaluate the effectiveness of polypharmacy, challenging tasks with traditional animal models; (5) reduce animal usage in drug evaluations. Notably, features from points (2) to (4) are capabilities not achievable by other in vitro models. The strategy proposed in this study can also be applied to the development of multi-organ microphysiological systems that mimic the physiological complexity of human organs or the entire body.","PeriodicalId":18560,"journal":{"name":"Microsystems & Nanoengineering","volume":"11 1","pages":"89"},"PeriodicalIF":7.3,"publicationDate":"2025-05-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12078732/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144078793","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Bio-inspired artificial hair flow sensors: a comprehensive review of design, fabrication, enhancements, and applications. 仿生人工发流传感器：设计、制造、增强和应用的全面回顾。

IF 7.3 1区工程技术

Microsystems & Nanoengineering Pub Date : 2025-05-13 DOI: 10.1038/s41378-025-00895-6

Lansheng Zhang, Zheyi Hang, Huan Hu

{"title":"Bio-inspired artificial hair flow sensors: a comprehensive review of design, fabrication, enhancements, and applications.","authors":"Lansheng Zhang, Zheyi Hang, Huan Hu","doi":"10.1038/s41378-025-00895-6","DOIUrl":"10.1038/s41378-025-00895-6","url":null,"abstract":"Flow measurement is critical in various sectors, including industry, agriculture, medicine, and environmental monitoring. There is a growing need for compact, sensitive, scalable, and energy-efficient flow sensors, particularly for applications in unmanned aerial vehicles, unmanned underwater vehicles, biomedicine, and bionic robotics. Inspired by biological mechanosensory structures, artificial hair and hair cell flow sensors have emerged as promising solutions. This study offers a comprehensive review of the progress, underlying principles, performance optimization techniques, and applications of hair flow sensors. We provide an overview of the biological mechanisms of hair as mechanical receptors. Subsequently, we explain the design and fabrication techniques of artificial hair flow sensors, highlighting the challenges associated with replicating and integrating hair structures. The study further explores strategies for sensor enhancement and their diverse applications. Finally, we conclude by outlining the challenges and prospects of hair sensor technology, along with its potential to address specific flow-sensing requirements. While most applications of artificial hair cell flow sensors are still in the research stage, they offer substantial potential for flow measurement. Future progress in materials science, structural design, and sensing mechanisms is anticipated to drive the development of these sensors, opening up new avenues for scientific research and commercial applications.","PeriodicalId":18560,"journal":{"name":"Microsystems & Nanoengineering","volume":"11 1","pages":"88"},"PeriodicalIF":7.3,"publicationDate":"2025-05-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12075567/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144063890","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Multi-sized microelectrode array coupled with micro-electroporation for effective recording of intracellular action potential. 多尺寸微电极阵列与微电穿孔相结合，有效记录细胞内动作电位。

IF 7.3 1区工程技术

Microsystems & Nanoengineering Pub Date : 2025-05-13 DOI: 10.1038/s41378-025-00887-6

Xingyuan Xu, Zhengjie Liu, Jing Liu, Chuanjie Yao, Xi Chen, Xinshuo Huang, Shuang Huang, Peng Shi, Mingqiang Li, Li Wang, Yu Tao, Hui-Jiuan Chen, Xi Xie

{"title":"Multi-sized microelectrode array coupled with micro-electroporation for effective recording of intracellular action potential.","authors":"Xingyuan Xu, Zhengjie Liu, Jing Liu, Chuanjie Yao, Xi Chen, Xinshuo Huang, Shuang Huang, Peng Shi, Mingqiang Li, Li Wang, Yu Tao, Hui-Jiuan Chen, Xi Xie","doi":"10.1038/s41378-025-00887-6","DOIUrl":"10.1038/s41378-025-00887-6","url":null,"abstract":"Microelectrode arrays (MEAs) are essential tools for studying the extracellular electrophysiology of cardiomyocytes in a multi-channel format. However, they typically lack the capability to record intracellular action potentials (APs). Recent studies have relied on costly fabrication of high-resolution microelectrodes combined with electroporation for intracellular recordings, but the impact of microelectrode size on micro-electroporation and the quality of intracellular signal acquisition has yet to be explored. Understanding these effects could facilitate the design of microelectrodes of various sizes to enable lower-cost manufacturing processes. In this study, we investigated the influence of microelectrode size on intracellular AP parameters and recording metrics post-micro-electroporation through simulations and experiments. We fabricated microelectrodes of different sizes using standard photolithography techniques to record cardiomyocyte APs from various culture environments with coupled micro-electroporation. Our findings indicate that larger microelectrodes generally recorded electrophysiological signals with higher amplitude and better signal-to-noise ratios, while smaller electrodes exhibited higher perforation efficiency, AP duration, and single-cell signal ratios. This work demonstrates that the micro-electroporation technique can be applied to larger microelectrodes for intracellular recordings, rather than being limited to high-resolution designs. This approach may provide new opportunities for fabricating microelectrodes using alternative low-cost manufacturing techniques for high-quality intracellular AP recordings.","PeriodicalId":18560,"journal":{"name":"Microsystems & Nanoengineering","volume":"11 1","pages":"85"},"PeriodicalIF":7.3,"publicationDate":"2025-05-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12075571/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143990314","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Stretchable multifunctional wearable system for real-time and on-demand thermotherapy of arthritis. 用于关节炎实时和按需热疗的可拉伸多功能可穿戴系统。

IF 7.3 1区工程技术

Microsystems & Nanoengineering Pub Date : 2025-05-13 DOI: 10.1038/s41378-025-00912-8

Zehan Liu, Xihan Wang, Yiyang He, Weiqiang Hong, Peng Sun, Weitao Liu, Dong Ye, Zhuoqing Yang, Xuewen Wang, Mengxi Wu, Liding Wang, Junshan Liu

{"title":"Stretchable multifunctional wearable system for real-time and on-demand thermotherapy of arthritis.","authors":"Zehan Liu, Xihan Wang, Yiyang He, Weiqiang Hong, Peng Sun, Weitao Liu, Dong Ye, Zhuoqing Yang, Xuewen Wang, Mengxi Wu, Liding Wang, Junshan Liu","doi":"10.1038/s41378-025-00912-8","DOIUrl":"10.1038/s41378-025-00912-8","url":null,"abstract":"Thermotherapy is a conventional and effective physiotherapy for arthritis. However, the current thermotherapy devices are often bulky and lack real-time temperature feedback and self-adjustment functions. Here, we developed a multifunctional wearable system for real-time thermotherapy of arthritic joints based on a multilayered flexible electronic device consisting of homomorphic hollow thin-film sensors and heater. The kirigami-serpentine thin-film sensors provide stretchability and rapid response to changes in environmental temperature and humidity, and the homomorphic design offers easy de-coupling of dual-modal sensing signals. Based on a closed-loop control, the thin-film Joule heater exhibits rapid and stable temperature regulation capability, with thermal response time < 1 s and maximum deviation < 0.4 °C at 45 °C. Based on the multifunctional wearable system, we developed a series of user-friendly gears and demonstrated programmable on-demand thermotherapy, real-time personal thermal management, thermal dehumidification, and relief of the pain via increasing blood perfusion. Our innovation offers a promising solution for arthritis management and has the potential to benefit the well-being of thousands of patients.","PeriodicalId":18560,"journal":{"name":"Microsystems & Nanoengineering","volume":"11 1","pages":"84"},"PeriodicalIF":7.3,"publicationDate":"2025-05-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12069628/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144018706","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A stretchable frequency reconfigurable antenna controlled by compressive buckling for W-band applications. 一种w波段压缩屈曲控制的可伸缩频率可重构天线。

IF 7.3 1区工程技术

Microsystems & Nanoengineering Pub Date : 2025-05-13 DOI: 10.1038/s41378-025-00890-x

Qi Wang, Zetian Wang, Yang Yang, Chi Zhang, Mengdi Han, Wei Wang, Yufeng Jin

{"title":"A stretchable frequency reconfigurable antenna controlled by compressive buckling for W-band applications.","authors":"Qi Wang, Zetian Wang, Yang Yang, Chi Zhang, Mengdi Han, Wei Wang, Yufeng Jin","doi":"10.1038/s41378-025-00890-x","DOIUrl":"10.1038/s41378-025-00890-x","url":null,"abstract":"Reconfigurable antennas have attracted significant interest because of their ability to dynamically adjust radiation properties, such as operating frequencies, thereby managing the congested frequency spectrum efficiently and minimizing crosstalk. However, existing approaches utilizing switches or advanced materials are limited by their discrete tunability, high static power consumption, or material degradation for long-term usage. In this study, we present a W-band frequency reconfigurable antenna that undergoes a geometric transformation from a two-dimensional (2D) precursor, selectively bonded to a prestretched elastomeric substrate, into a desired 3D layout through controlled compressive buckling. Modeling the buckling process using combined mechanics-electromagnetic finite element analysis (FEA) allows for the rational design of the antenna with desired strains applied to the substrate. By releasing the substrate at varying compression ratios, the antenna reshapes into different 3D configurations, enabling continuous frequency reconfigurability. Simulation and experimental results demonstrate that the antenna's resonant frequency can be tuned from 77 GHz in its 2D state to 94 GHz in its 3D state in a folded-dipole-like design.","PeriodicalId":18560,"journal":{"name":"Microsystems & Nanoengineering","volume":"11 1","pages":"86"},"PeriodicalIF":7.3,"publicationDate":"2025-05-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12075831/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144033258","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

PEDOT:PSS-based bioelectronics for brain monitoring and modulation. 基于pss的脑监测和调制生物电子学。

IF 7.3 1区工程技术

Microsystems & Nanoengineering Pub Date : 2025-05-13 DOI: 10.1038/s41378-025-00948-w

Jing Li, Daize Mo, Jinyuan Hu, Shichao Wang, Jun Gong, Yujing Huang, Zheng Li, Zhen Yuan, Mengze Xu

{"title":"PEDOT:PSS-based bioelectronics for brain monitoring and modulation.","authors":"Jing Li, Daize Mo, Jinyuan Hu, Shichao Wang, Jun Gong, Yujing Huang, Zheng Li, Zhen Yuan, Mengze Xu","doi":"10.1038/s41378-025-00948-w","DOIUrl":"10.1038/s41378-025-00948-w","url":null,"abstract":"The growing demand for advanced neural interfaces that enable precise brain monitoring and modulation has catalyzed significant research into flexible, biocompatible, and highly conductive materials. PEDOT:PSS-based bioelectronic materials exhibit high conductivity, mechanical flexibility, and biocompatibility, making them particularly suitable for integration into neural devices for brain science research. These materials facilitate high-resolution neural activity monitoring and provide precise electrical stimulation across diverse modalities. This review comprehensively examines recent advances in the development of PEDOT:PSS-based bioelectrodes for brain monitoring and modulation, with a focus on strategies to enhance their conductivity, biocompatibility, and long-term stability. Furthermore, it highlights the integration of multifunctional neural interfaces that enable synchronous stimulation-recording architectures, hybrid electro-optical stimulation modalities, and multimodal brain activity monitoring. These integrations enable fundamentally advancing the precision and clinical translatability of brain-computer interfaces. By addressing critical challenges related to efficacy, integration, safety, and clinical translation, this review identifies key opportunities for advancing next-generation neural devices. The insights presented are vital for guiding future research directions in the field and fostering the development of cutting-edge bioelectronic technologies for neuroscience and clinical applications.","PeriodicalId":18560,"journal":{"name":"Microsystems & Nanoengineering","volume":"11 1","pages":"87"},"PeriodicalIF":7.3,"publicationDate":"2025-05-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12075682/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144063821","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0