Medicine最新文献

{"title":"A Bibliometric Analysis of hypertension and anxiety from 2004 to 2022.","authors":"Si-Qi Liu, Xin-Yu Ji, Hai-Yi Liang, Shu-Han Zhao, Fu-Yi Yang, Yang Tang, Shuai Shi","doi":"10.1097/MD.0000000000041859","DOIUrl":"10.1097/MD.0000000000041859","url":null,"abstract":"<p><strong>Background: </strong>A growing body of clinical evidence points to an association between hypertension and anxiety, but the mechanisms by which the two occur are unclear. This article aims to explore possible common influences and associations between hypertension and anxiety.</p><p><strong>Methods: </strong>We searched for publications on hypertension and anxiety from January 01, 2004 to December 31, 2022 in Web of Science and performed bibliometrics using CiteSpace, VOSviewer, Scimago Graphica and Gephi.</p><p><strong>Results: </strong>A total of 3216 related articles were retrieved from the Web of Science database. After screening, 3051 articles were included. The number of published articles has increased over the past 19 years. The United States has more researches in this area and has strong collaborative relationships with other countries, which gives it some credibility and authority. The words that appear in the burst keywords are gender, age, obesity, depression, panic disorder, pregnancy induced hypertension, coronary heart disease, chronic kidney disease, and pituitary adrenal axi, which are co-related with hypertension and anxiety.</p><p><strong>Conclusion: </strong>There is a link between hypertension and anxiety, and the 2 influence each other, usually in a positive way. Common influences on hypertension and anxiety include age, gender, obesity, depression, panic attacks, pregnancy, coronary heart disease and chronic kidney disease. Recent research hotspots have focused on population aging and comorbidities. Future research hotspots are likely continue to focus on influencing factors, clinical research and prognosis.</p>","PeriodicalId":18549,"journal":{"name":"Medicine","volume":"104 13","pages":"e41859"},"PeriodicalIF":1.3,"publicationDate":"2025-03-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11957653/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143735812","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Parasite load as a marker of pathogenicity in Dientamoeba fragilis infections.","authors":"Ander Burgaña Agoües, Rosa Abellana Sangra, Mónica Ballestero-Téllez, Mireia Rajadell-Guiu, Marc Garreta-Esteban, Tomàs M Perez-Porcuna","doi":"10.1097/MD.0000000000041963","DOIUrl":"10.1097/MD.0000000000041963","url":null,"abstract":"<p><p>Dientamoeba fragilis is a globally widespread intestinal parasite and one of the most frequent in humans, often leading to primary care consultations. The pathogenic potential of this parasite remains unclear due to limited evidence and contradictory study results. This study investigated the pathogenicity of D fragilis, focusing on the critical knowledge gap regarding the relationship between parasite load and associated symptomatology. A prospective case-control study matched by household unit was conducted, considering individuals with gastrointestinal symptoms and D fragilis in stool as cases, and their asymptomatic household members with D fragilis in stools as controls. D fragilis detection was performed in parallel using light microscopy and real time-polymerase chain reaction. The study was carried out in 7 primary care centers over 12 months. Parasite load was measured as the number of trophozoites per field at a magnification of 40x by microscopy and by cycle threshold values in RT-PCR. A total of 218 individuals were recruited: 74 symptomatic cases and 144 household members, of whom 57 (39.6%) were D fragilis-positive asymptomatic controls. The proportion of individuals with D fragilis and a parasite load less than 1 trophozoite per field was higher in asymptomatic individuals (controls) than in symptomatic cases (47.7% vs 3.1%, respectively) (P < .001). Parasite load is associated with the presence of gastrointestinal symptoms, supporting the pathogenicity of D fragilis. Any diagnostic approach for D fragilis should incorporate or be complemented by quantitative information to accurately estimate parasite load and enhance treatment decision-making.</p>","PeriodicalId":18549,"journal":{"name":"Medicine","volume":"104 13","pages":"e41963"},"PeriodicalIF":1.3,"publicationDate":"2025-03-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11957650/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143736067","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A case report of liver failure caused by Tetrastigma hemsleyanum Diels et Gilg: A rare case report and literature review.","authors":"Yan Liu, Xia Zhou, Qiong-Fen Wang, Ming-Wei Liu","doi":"10.1097/MD.0000000000042059","DOIUrl":"10.1097/MD.0000000000042059","url":null,"abstract":"<p><strong>Rationale: </strong>Tetrastigma hemsleyanum Diels et Gilg is a traditional Chinese medicinal plant recognized for its therapeutic properties, which include heat-clearing, toxicity-eliminating, anti-inflammatory, pain-relieving, blood circulation-promoting, blood stasis-resolving, wind-dispersing, and phlegm-resolving actions. It is predominantly used in clinical settings to manage inflammatory disorders, such as febrile convulsions, hepatitis, snakebites, and cellulitis. To date, no documented cases of liver failure attributable to T hemsleyanum Diels et Gilg have been reported.</p><p><strong>Patient concerns: </strong>A 50-year-old female patient presented with symptoms of xanthochromia, tea-colored urine, fatigue, and anorexia following a three-day course of T hemsleyanum Diels et Gilg. Liver function tests revealed elevated alanine aminotransferase (1386 U/L) and AST (405 U/L) levels.</p><p><strong>Diagnoses: </strong>Liver failure induced by T hemsleyanum Diels et Gilg was diagnosed.</p><p><strong>Interventions: </strong>The patient received treatment that included discontinuation of hepatotoxic drugs, administration of N-acetylcysteine for liver protection, nutritional support, and correction of acid-base and electrolyte imbalances.</p><p><strong>Outcomes: </strong>After 11 days of liver-protective and nutritional therapy, significant improvements in the patient's condition were noted. The symptoms of xanthochromia and tea-colored urine subsided, and liver function markers decreased markedly, returning to near-normal levels. No further complaints of discomfort were reported, and the patient was discharged with prescribed medications for follow-up.</p><p><strong>Lesson: </strong>The possibility of liver failure following the use of T hemsleyanum Diels et Gilg should be considered. When patients present with symptoms such as fat intolerance, xanthochromia, poor appetite, nausea, and dark urine after consuming this herb, liver function tests should be promptly conducted to exclude the possibility of drug-induced liver injury. T hemsleyanum Diels et Gilg has the potential to induce liver failure. Liver-protective measures, including nutritional support, proved to be effective in managing the condition.</p>","PeriodicalId":18549,"journal":{"name":"Medicine","volume":"104 13","pages":"e42059"},"PeriodicalIF":1.3,"publicationDate":"2025-03-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11957641/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143735962","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Intermediate metastatic risk lipomatous solitary fibrous tumor of the thigh (previously known as hemangiopericytoma): A rare case report with a literature review.","authors":"Ghefar Hmaydoosh, Youssef Ahmad, Muhsen Issa, Ghanem Ahmad, Duaa Knaj, Issa Ahmad, Rana Issa","doi":"10.1097/MD.0000000000042052","DOIUrl":"10.1097/MD.0000000000042052","url":null,"abstract":"<p><strong>Rationale: </strong>Solitary fibrous tumor (SFT) is a rare mesenchymal tumor, which can arise at any anatomical location and exhibit a wide variety of histopathological characteristics. Lipomatous solitary fibrous tumor (LSFT) is a rare variant of SFT characterized by hemangiopericytoma-like vascular areas with a varying amount of adipocytic tissue. LSFT can be misdiagnosed with other tumors such as liposarcoma which can lead to unnecessary overtreatment for patients.</p><p><strong>Patient concerns: </strong>A 48-year-old man presented to the hospital clinic with a painless swelling located on the medial area of the upper thigh near the femoral artery, he has not seen any change in its size since he has noticed it a year ago.</p><p><strong>Diagnoses: </strong>Histological examination confirmed LSFT with an intermediate risk of metastasis.</p><p><strong>Interventions: </strong>Three-dimensional imaging technology with intravenous injection of contrast material was made and revealed a mass with well-vascularity supplied from the deep femoral artery. The lesion was excised and showed an intramuscular well-circumscribed encapsulated mass.</p><p><strong>Outcomes: </strong>The pathological findings LSFT with intermediate metastatic risk, and he is scheduled to receive radiotherapy for one and a half months. The majority of SFTs display benign histological characteristics and typically follow a slow clinical progression, leading to a favorable prognosis. To date, fewer than 20 cases of malignant LSFT have been documented. In our case, we utilized a recent tumor classification model that evaluates the metastatic potential of SFTs, and long-term follow-up is necessary because there is a chance of aggressive behavior.</p><p><strong>Lessons: </strong>LSFTs are usually found incidentally and often present as painless, movable masses. Even though they mostly follow a benign course, long-term follow-up is essential due to the possibility of turning malignant.</p>","PeriodicalId":18549,"journal":{"name":"Medicine","volume":"104 13","pages":"e42052"},"PeriodicalIF":1.3,"publicationDate":"2025-03-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11957647/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143735972","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Jieji Xuanfei Chuyi granules in the treatment of COVID-19: A randomized, open-label, parallel-controlled clinical trial.","authors":"Zhiyu Tian, Li Shi, Yingzi Cui, Shaodan Hu, Huan Ding, Feng Sun, Zhenghua Cao","doi":"10.1097/MD.0000000000041740","DOIUrl":"10.1097/MD.0000000000041740","url":null,"abstract":"<p><strong>Background: </strong>New drugs are needed for coronavirus disease 2019 (COVID-19).</p><p><strong>Methods: </strong>We conducted a randomized, open-label, positive-drug parallel-controlled trial to evaluate Jieji Xuanfei Chuyi granules (JJXFCY), a Chinese patent medicine, administered within 7 days of the onset of symptoms of mild-to-moderate, laboratory-confirmed COVID-19 in adults. Participants (n = 120) received JJXFCY or Lianhua Qingwen granules (LHQW), as control, 3 times daily. The primary outcome was the time for negative reverse transcription-PCR severe acute respiratory syndrome coronavirus 2 test and symptom relief after 7 days of treatment. The primary safety end point was adverse events.</p><p><strong>Results: </strong>Baseline characteristics were mostly similar in the JJXFCY and LHQW groups. After 7 days of treatment, clinical symptoms were relieved in both groups to a certain extent. Fever, nausea, vomiting, and sticky stool disappeared on day 7. After 15 days, cough, sputum, and nasal congestion were mainly observed. After 28 days, cough, shortness of breath, phlegm, and runny nose still existed in some subjects. No deaths were observed. Adverse events occurred in 21.7% (13/60) and 15% (9/60) of JJXFCY and LHQW groups, respectively.</p><p><strong>Conclusion: </strong>JJXFCY has therapeutic effects in treating mild COVID-19 cases. It reduced the persistence of COVID-19 symptoms, improved outcomes, and reduced the risk of hospitalization or death in adults with COVID-19.</p>","PeriodicalId":18549,"journal":{"name":"Medicine","volume":"104 13","pages":"e41740"},"PeriodicalIF":1.3,"publicationDate":"2025-03-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11957630/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143735980","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"High blood pressure in secondary school adolescents: Disease burden in the Bamenda municipality, North West region of Cameroon.","authors":"Andreas Chiabi, Mvuchiim N Barah, Ahamadou M Jingi, Kate Kan, Cecilia Fomenky, Mary C Garba, Guy Wafeu","doi":"10.1097/MD.0000000000041970","DOIUrl":"10.1097/MD.0000000000041970","url":null,"abstract":"<p><p>This study aims to evaluate the prevalence and factors associated with high blood pressure in secondary school adolescents in the Bamenda municipality, the North West region of Cameroon. A community-based cross-sectional study was conducted over 5 months, involving 720 adolescents aged 10 to 19 years from 13 secondary schools, using a multi-stage sampling approach. Blood pressure was measured using both oscillometric and mercury sphygmomanometer devices. Weight, height, and body mass index (BMI) were also assessed. Participants with high blood pressure values at the first visit underwent repeat screening for over 3 weeks and hypertension defined according to American Academy of Pediatrics guidelines. Logistic regression analyzed factors associated with hypertension, considering P < .05 as statistically significant at 95% Confidence Interval. The prevalence of hypertension was 5% (4% for stage I and 1% for stage II) and that of elevated Blood Pressure was 4.3%. There was an increase in blood pressure with an increase in age. Systolic blood pressure and diastolic blood pressure were significantly positively correlated with BMI. There was a significant association between enrolled in private school (aOR = 0.32; P = .006) and obesity (aOR = 2.94; P = .017) with hypertension in these participants. This study provides valuable insights into the alarming prevalence of hypertension among secondary school adolescents in Bamenda, Cameroon. The identification of key risk factor, obesity, calls for comprehensive strategies to promote healthy lifestyle, regular screening and timely management of high blood pressure in this vulnerable population.</p>","PeriodicalId":18549,"journal":{"name":"Medicine","volume":"104 13","pages":"e41970"},"PeriodicalIF":1.3,"publicationDate":"2025-03-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11957640/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143736015","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Research trends on spinal muscular atrophy from 1995 to 2023: A bibliometric analysis.","authors":"Hao Yu, Cuijie Wei, Dan Sun, Li Zhang, Yanyan Xia, Wenhua Zhu","doi":"10.1097/MD.0000000000041801","DOIUrl":"10.1097/MD.0000000000041801","url":null,"abstract":"<p><strong>Background: </strong>Spinal muscular atrophy (SMA) is a neuromuscular disease characterized by progressive muscle weakness due to motor neuron degeneration. The discovery of the survival motor neuron 1 (SMN1) gene in 1995 revolutionized SMA research, leading to significant therapeutic advancements. This bibliometric analysis aimed to explore global trends in SMA research and therapy, with a particular focus on China.</p><p><strong>Methods: </strong>A comprehensive database search identified 4506 relevant publications (3812 articles, 694 reviews) published between 1995 and 2023. Bibliometric tools were used to analyze publication trends, collaborations, and research topics.</p><p><strong>Results: </strong>SMA research has experienced substantial growth, with the United States leading in publications followed by the United Kingdom and Germany. China has shown increasing engagement in this field. Key research areas include genetic and molecular mechanisms, survival motor neuron gene therapy, antisense oligonucleotides, and muscle strength-promoting factors. Chinese researchers have contributed significantly to these areas, with a higher reporting frequency of SMA-related topics compared to other countries.</p><p><strong>Conclusion: </strong>This bibliometric analysis provides a comprehensive overview of global SMA research, highlighting significant advancements, and identifying future directions. The findings offer valuable insights for researchers, clinicians, and policymakers in China to ensure alignment with global medical advancements and improve the lives of individuals affected by SMA.</p>","PeriodicalId":18549,"journal":{"name":"Medicine","volume":"104 13","pages":"e41801"},"PeriodicalIF":1.3,"publicationDate":"2025-03-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11957644/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143736043","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Pancreatic sarcoidosis: A case report and literature review.","authors":"Rui Li, Chenghua Zhu, Nan Gao, Qian Liu, Qiang Du","doi":"10.1097/MD.0000000000041957","DOIUrl":"10.1097/MD.0000000000041957","url":null,"abstract":"<p><strong>Rationale: </strong>Sarcoidosis is a multisystem disease of unknown etiology that usually involves the lungs and hilar lymph nodes and rarely involves the digestive system other than the liver.</p><p><strong>Patient concerns: </strong>A woman with no medical history presented with 2 pulmonary nodules and a pancreatic mass on chest computed tomography (CT) because of sputum production and shortness of breath.</p><p><strong>Diagnoses: </strong>Ultrasound bronchoscopy and pathology showed pulmonary sarcoidosis.</p><p><strong>Interventions: </strong>Oral prednisone acetate.</p><p><strong>Outcomes: </strong>In the following year of follow-up, the pancreatic, lung and mediastinal lesions were significantly reduced.</p><p><strong>Lessons: </strong>Corticosteroid therapy may therefore constitute a different kind of diagnosis.</p>","PeriodicalId":18549,"journal":{"name":"Medicine","volume":"104 13","pages":"e41957"},"PeriodicalIF":1.3,"publicationDate":"2025-03-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11957636/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143736062","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Wider means worsen? Influence of QRS duration of left bundle branch block on prognosis of patients after transcatheter aortic valve replacement.","authors":"Jiajun Pan, Zhimin Zhao, Bailing Li, Hao Zhang, Chengliang Cai, Yun Tao, Fan Qiao, Fanglin Lu, Lin Han, Zhiyun Xu","doi":"10.1097/MD.0000000000041940","DOIUrl":"10.1097/MD.0000000000041940","url":null,"abstract":"<p><p>The impact of QRS duration on postoperative LBBB and its implications for the prognosis of patients undergoing transcatheter aortic valve replacement (TAVR) remained uncertain. This study enrolled consecutive patients who underwent TAVR with self-expanding prostheses in our department from September 2017 to January 2021. Based on the pro-discharge electrocardiogram, patients were categorized into 3 groups: Group-NCD (no conduction disorder), Group-sLBBB (LBBB, QRS ≥ 150 ms), and Group-mLBBB (LBBB, QRS < 150 ms). Basic characteristics were compared among these groups. Furthermore, differences in left ventricular ejection fraction (LVEF), survival rates, and clinical events were assessed at baseline, discharge, and during a one-year follow-up period. A total of 56 patients were included in the study. With 17 (30.36%) experiencing new-onset LBBB, of which eleven had a QRS duration ≥ 150 ms. Group-sLBBB exhibited a longer left ventricular end-diastolic diameter at baseline. At a one-year follow-up, the LVEF improved in Group-NCD, but not in the LBBB groups. At discharge, the LVEF of Group-sLBBB was lower than that of Group-NCD (52.82 ± 11.48 vs 61.48 ± 10.10, P = .036) and remained lower at follow-up (57.10 ± 9.49 vs 65.85 ± 7.58, P = .011). Additionally, the LVEF of Group-sLBBB was lower than that of Group-mLBBB at discharge (52.82 ± 11.48 vs 63.17 ± 4.31, P = .018). However, there were no significant differences in survival and event-free survival among the groups. The study revealed a notable occurrence of new-onset LBBB following TAVR, with a majority of cases exhibiting a significantly prolonged QRS duration (≥150 ms). While the presence of LBBB did not impact one-year survival or clinical events, it did exert adverse effects on LVEF. Notably, when QRS duration was markedly prolonged, these adverse effects manifested earlier and were more pronounced.</p>","PeriodicalId":18549,"journal":{"name":"Medicine","volume":"104 13","pages":"e41940"},"PeriodicalIF":1.3,"publicationDate":"2025-03-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11957652/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143735865","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Patient physical condition and functional sequelae following hospitalization with COVID-19: A cross-sectional observational study.","authors":"Daniel Ángel García, Inmaculada Calvo Muñoz, Ismael Martínez Nicolás, Bianca Salmeri","doi":"10.1097/MD.0000000000041948","DOIUrl":"10.1097/MD.0000000000041948","url":null,"abstract":"<p><p>After hospitalization caused by COVID-19, a high prevalence of physical deterioration has been observed, hence the importance of having tests to evaluate the functional status of patients and to be able to perform a partition and subsequent referral to the physiotherapy service. This cross-sectional observational study describes the physical status according to the short physical performance battery (SPPB) of patients admitted to the hospital setting for COVID-19 and to identify variables potentially related to this outcome. Thirty-six patients admitted to the hospital setting for COVID-19 in the first wave living in the community. Patients were evaluated with the SPPB, strength test, the International Physical Activity Questionnaire, the 1-minute sit-to stand, spirometry, the Barthel index, the Hospital Anxiety and Depression Scale, and other patient-related data were collected. We performed bivariate and regression analyses. A linear regression was fitted, having SPPB as a dependent variable to ascertain the impact of intensive care unit (ICU) admission on physical performance. Five variables were related to SPPB. There was a significant relationship between admission to the ICU and having a heart disease (P = .015), the level of physical activity (P = .049), number of years smoking (P = .029) and days of hospitalization (P = .005). A total of 22.22% of analyzed patients suffered frailty. SPPB is related to altered respiratory pattern, quadriceps strength, 1-minute sit-to-stand and FEV1, Barthel score, days of hospitalization and FEV/FVC ratio. Lack of association between ICU stay, age or sex with SPPB results differs from the results of other studies.</p>","PeriodicalId":18549,"journal":{"name":"Medicine","volume":"104 13","pages":"e41948"},"PeriodicalIF":1.3,"publicationDate":"2025-03-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11957633/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143736019","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}