Medicine最新文献

{"title":"Vagal nerve magnetic stimulation for post-traumatic cricopharyngeal achalasia with bilateral vocal cord paralysis: A case report.","authors":"Lirong Liu, Shujuan Huang, Hanbo Chen, Si Chen, Jinfeng Liang, Churong Liu","doi":"10.1097/MD.0000000000043525","DOIUrl":"10.1097/MD.0000000000043525","url":null,"abstract":"<p><strong>Rationale: </strong>Post-traumatic dysphagia is a severe complication of traumatic brain injury, particularly in cases involving medullary damage. The rare combination of cricopharyngeal achalasia and bilateral vocal cord paralysis presents substantial challenges, with profound swallowing dysfunction and increased aspiration risk. Current treatments primarily target cricopharyngeal dysfunction but lack effective solutions for concurrent vocal cord paralysis, highlighting the need for innovative therapeutic strategies.</p><p><strong>Patient concerns: </strong>A 15-year-old male presented with severe dysphagia, confirmed as upper esophageal sphincter (UES) dysfunction and bilateral vocal cord paralysis. The patient exhibited severe aspiration (grade V water swallowing test, penetration aspiration scale: score of 7) and elevated UES residual pressure (28.2 mm Hg, normal < 12.0 mm Hg).</p><p><strong>Diagnoses: </strong>Post-traumatic neurogenic dysphagia with cricopharyngeal achalasia and bilateral vocal cord paralysis secondary to medullary damage.</p><p><strong>Interventions: </strong>An individualized protocol combining vagus nerve magnetic stimulation (VNMS) and conventional rehabilitation was implemented. VNMS targeted the left vagus nerve using 5 Hz stimulation at 80% resting motor threshold, while rehabilitation included pulmonary exercises, balloon dilation therapy, and tongue base pressure training.</p><p><strong>Outcomes: </strong>Substantial improvements were observed. UES residual pressure decreased from 28.2 mm Hg to 2.7 mm Hg, penetration aspiration scale score improved from 7 to 2, and the functional oral intake scale increased from level 1 to level 6, enabling oral feeding and removal of the tracheostomy and gastric tube. No adverse events were reported.</p><p><strong>Lessons: </strong>This case highlights the potential of VNMS as a noninvasive and effective treatment for complex post-traumatic brain injury dysphagia involving cricopharyngeal achalasia and bilateral vocal cord paralysis. By addressing dual swallowing-related pathologies, VNMS offers a promising therapeutic approach in neurorehabilitation. Further research is warranted to validate these findings and explore broader clinical applications.</p>","PeriodicalId":18549,"journal":{"name":"Medicine","volume":"104 30","pages":"e43525"},"PeriodicalIF":1.4,"publicationDate":"2025-07-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144732306","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Risk factors for hrHPV infection with cervical lesions patient in Anhui Province of China from 2021 to 2024: A retrospective study.","authors":"Suxia Hu, Yijing Li, Miaomiao Hu, Zejin Wang, Miaomiao Du","doi":"10.1097/MD.0000000000043384","DOIUrl":"10.1097/MD.0000000000043384","url":null,"abstract":"<p><p>The association between high-risk HPV (hrHPV) infection and cervical cancer or precancerous lesions has been extensively established, highlighting the importance of preventing hrHPV infection in cervical lesions patients. This study aims to investigate the risk factors associated with hrHPV infection in patients with cervical lesions and develop a nomogram model for predicting the risk of infection. The study involved 154 patients with cervical lesions, all of whom underwent human papillomavirus (HPV) gene typing. Retrospectively analyze the HPV genotyping and assess the prevalence of HPV infection in patients. The patients with cervical lesions were separated into hrHPV (n = 100) and non-hrHPV group (n = 54) based on the results of HPV genotyping tests. Univariate and multivariate regression analyses were employed to identify independent risk factors and develop nomogram model. The performance of the nomogram model were evaluated using ROC analysis. There were a total of 114 patients who tested positive for HPV, comprising 100 hrHPV and 14 low-risk HPV. The most common types of HPV are HPV 16 (65.00%), followed by HPV 52 (3.00%) and HPV 58 (3.00%). Univariate and multivariate analyses showed that age of first sexual intercourse (odds ratio [OR] = 3.312), miscarriage (OR = 7.115), menopause (OR = 2.508), cervicitis (OR = 2.710), number of sexual partners (OR = 5.259) were identified as significant risk factors for hrHPV infection. The nomogram model shows an area under the curve value of 0.861 (95% confidence interval = 0.795-0.927), with a sensitivity of 95.6% and specificity of 92.3%. These findings indicate the significant practical value of the clinical risk nomogram model. Age of first sexual intercourse, miscarriage, menopause, cervicitis, and number of sexual partners were identified as risk factors for hrHPV infection in patients with cervical lesions. This nomogram model holds significant clinical value.</p>","PeriodicalId":18549,"journal":{"name":"Medicine","volume":"104 30","pages":"e43384"},"PeriodicalIF":1.4,"publicationDate":"2025-07-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144732177","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Causal effects and immune cells mediators between gut microbiota and sicca syndrome: A Mendelian randomization study.","authors":"Jian Yue, Qian Yang, Sheng Chen, Guoxing Huang","doi":"10.1097/MD.0000000000043553","DOIUrl":"10.1097/MD.0000000000043553","url":null,"abstract":"<p><p>This study sought to investigate the causal relationship between gut microbiota (GM) and sicca syndrome (SS), as well as to identify and quantify potential immune cell traits as mediators in this association. The analysis incorporated data from genome-wide association studies, encompassing 473 GM variables, 731 immune cell traits, and SS. The primary method of analysis was inverse variance weighting. Sensitivity analyses, such as Cochran Q test, Mendelian randomization pleiotropy RESidual sum and outlier test, Mendelian randomization-Egger regression intercept, and leave-one-out analysis, were conducted to assess the stability and reliability of the results. Notably, our mediation analysis identified 8 immune cell traits that act as mediators in the causal association between GM and SS. Specifically, Bacteroides A abundance in stool, Bifidobacteriaceae abundance in stool, CAG-776 sp000438195 abundance in stool, and CAG-81 sp000435795 abundance in stool were found to be causally linked to SS. The corresponding immune cell mediators involved in these relationships are forward scatter-area on human leukocyte antigen (HLA) DR+ T cell, CD14+ CD16- monocyte %monocyte, TD CD8br AC, and CD33dim HLA DR+ CD11b+ %CD33dim HLA DR+, respectively. The mediation effect proportions for these associations were determined as -2.35%, -3.57%, -7.5%, and -5.4%, respectively. Moreover, Clostridium M clostridioforme abundance in stool was associated with SS and mediated by 2 immune cell traits: CD45 on HLA DR+ CD8br and CD4RA on TD CD4+. The mediation effect proportions for these associations were -3.9% and 3.7%, respectively. Similarly, Pandoraea abundance in stool was associated with SS and mediated by 2 immune cell traits: CD3 on CD4 regulatory T cell and CD28 on CD39+ secreting regulatory T cell. The mediation effect proportions for these associations were -15.7% and 8.5%, respectively. In conclusion, this study provides evidence for a causal relationship between GM and SS, demonstrating the role of immune cell traits as mediators in this causal association.</p>","PeriodicalId":18549,"journal":{"name":"Medicine","volume":"104 30","pages":"e43553"},"PeriodicalIF":1.4,"publicationDate":"2025-07-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144732192","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Fear-avoidance beliefs increase the perception of pain and disability in Saudi Arabian patients with chronic low back pain.","authors":"Mazyad A Alotaibi, Ahmed S Alhowimel, Faris A Alodaibi, Dalia Alimam, Mshari Alghadier, Ragab K Elnaggar","doi":"10.1097/MD.0000000000043510","DOIUrl":"10.1097/MD.0000000000043510","url":null,"abstract":"<p><p>Fear-avoidance beliefs are recognized globally as psychological factors contributing to chronic low back pain (CLBP), influencing pain perception and disability. While this relationship has been explored across various populations, there is limited evidence in Asian countries, including Saudi Arabia. Understanding regional variations is essential for developing culturally sensitive interventions. This study analyzes the relationship between fear-avoidance beliefs with pain and disability in Saudi Arabian patients with CLBP and analyze potential differences between subgroups according to the time of evolution. A cross-sectional study was conducted among 178 patients aged 18 to 65 years diagnosed with CLBP. Sociodemographic data, pain intensity, disability (Roland Morris Questionnaire), and fear-avoidance beliefs questionnaire were collected. Participants had a mean age of 42.3 ± 11.6 years; 50% were male, for the disability model, the significant predictors were interference, fear-avoidance beliefs questionnaire-physical activity, and occupation. The significant predictors for the pain intensity model were interference, age, and duration. The R2 for the disability model was 0.33, indicating that the included variables can explain 33% of the variance in disability, while the R2 for the pain intensity model was 0.50, indicating that the included variables can explain 50% of the variance in pain intensity. Fear-avoidance beliefs and pain interference significantly contribute to disability and pain in Saudi CLBP patients. Although age was a contributing factor, the wide age range may limit generalizability. These findings, however, emphasize the need for pain interference and fear-avoidance interventions in patients with CLBP to reduce disability and improve outcomes.</p>","PeriodicalId":18549,"journal":{"name":"Medicine","volume":"104 30","pages":"e43510"},"PeriodicalIF":1.4,"publicationDate":"2025-07-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144732200","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Decreased factor XIII activity and haptoglobin may be markers of enhanced-fibrinolytic-type disseminated intravascular coagulation status: Case report.","authors":"Shinya Yamada, Hideyasu Ueda, Yukio Suga, Toshihiro Miyamoto, Hidesaku Asakura","doi":"10.1097/MD.0000000000043123","DOIUrl":"10.1097/MD.0000000000043123","url":null,"abstract":"<p><strong>Rationale: </strong>Aortic aneurysms are often accompanied by enhanced-fibrinolytic-type disseminated intravascular coagulation (DIC), but markers to adequately assess DIC status remain lacking.</p><p><strong>Patient concerns: </strong>An 80-year-old man scheduled for thoracic endovascular aortic repair for aortic aneurysm was diagnosed with enhanced-fibrinolytic-type DIC. The concern was whether surgery could be safely performed in a state of enhanced-fibrinolytic-type DIC with a bleeding tendency.</p><p><strong>Interventions: </strong>He was treated with a combination of heparin and tranexamic acid.</p><p><strong>Outcomes: </strong>DIC was well controlled and the surgery was performed safely. However, DIC worsened again postoperatively. Since no severe bleeding symptoms were observed, no therapeutic intervention for DIC was performed postoperatively. During this period, coagulation tests including factor XIII activity and haptoglobin were followed over time to clarify the relevance of these markers.Factor XIII activity was decreased and haptoglobin was mildly decreased in DIC. Improvement of DIC led to normalization of both markers. Re-exacerbation of DIC led to decreased factor XIII activity and mildly decreased haptoglobin.</p><p><strong>Lessons: </strong>Factor XIII activity and haptoglobin appear to represent useful markers of DIC status.</p>","PeriodicalId":18549,"journal":{"name":"Medicine","volume":"104 30","pages":"e43123"},"PeriodicalIF":1.4,"publicationDate":"2025-07-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144732208","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effect of positive reinforcement nursing combined with standardized detailed care in emergency infusion patients.","authors":"Min Liu, Linfang Li, Yuqing Xia, Minfei Huang, Xueke Fan, Yihui Shen","doi":"10.1097/MD.0000000000043456","DOIUrl":"10.1097/MD.0000000000043456","url":null,"abstract":"<p><p>Intravenous infusion is a common and critical treatment modality in the emergency department. Optimizing infusion nursing quality is essential for improving patient clinical outcomes. This study aims to evaluate the efficacy of positive reinforcement nursing interventions in patients receiving emergency infusions. This retrospective study included 971 patients who underwent infusion therapy in the emergency department from February 2023 to February 2024. Based on different nursing interventions, patients were divided into the experimental group (476 patients receiving positive reinforcement nursing) and the control group (495 patients receiving routine nursing). After propensity score matching, each group comprised 320 patients. Data collected included general patient information, Modified Early Warning Score, Self-Rating Anxiety Scale, Self-Rating Depression Scale, Visual Analog Scale for pain, nursing satisfaction, and Nottingham Health Profile quality of life scores. Statistical analyses were performed using SPSS software, with a significance level set at P < .05. Post-matching, there were no significant differences in baseline characteristics between the 2 groups (P > .05). On the first and third days of infusion, the experimental group exhibited significantly lower Visual Analog Scale scores compared to the control group (P < .05). Following nursing interventions, the experimental group showed significantly lower Self-Rating Anxiety Scale and Self-Rating Depression Scale scores than the control group (P < .001). Regarding infusion-related adverse events, the experimental group had a significantly lower incidence of repeated punctures and redness/swelling at the puncture site compared to the control group (P < .05). In terms of nursing satisfaction, the experimental group scored significantly higher in nursing skills, infusion room environment, and infusion management compared to the control group (P < .05). For quality of life, the experimental group had significantly lower Nottingham Health Profile scores in all dimensions except social life compared to the control group (P < .05). Positive reinforcement nursing interventions significantly reduce pain perception in emergency infusion patients, improve their psychological state, decrease the incidence of infusion-related adverse events, and enhance nursing satisfaction and quality of life. These findings highlight the clinical value of integrating positive reinforcement strategies into infusion nursing practices in emergency settings.</p>","PeriodicalId":18549,"journal":{"name":"Medicine","volume":"104 30","pages":"e43456"},"PeriodicalIF":1.4,"publicationDate":"2025-07-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144732223","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Relationship between temporal white matter projections and cognition in patients with putaminal hemorrhage: An observational study.","authors":"Sung Ho Jang, Hyeok Gyu Kwon","doi":"10.1097/MD.0000000000042728","DOIUrl":"10.1097/MD.0000000000042728","url":null,"abstract":"<p><p>Cognitive impairment in patients with putaminal hemorrhage (PH) is not well understood, particularly the role of temporal white matter projections. The temporal white matter projections (cingulum, superior longitudinal fasciculus, inferior longitudinal fasciculus, and uncinate fasciculus [UF]) is involved in the cognitive function. Therefore, a brain injury involving the temporal white matter projections results in cognitive impairment. However, few studies have reported the pathophysiological mechanisms associated with cognitive impairment in patients with PH. Hence, in this study, using diffusion tensor tractography (DTT), the relationship between the temporal white matter projections and cognition was analyzed in patients with PH. Twenty-five patients with PH were recruited for this study. A Mini-Mental State Examination (MMSE) was conducted for the cognitive function. DTT was used to evaluate the structural integrity of temporal white matter projections (cingulum, superior longitudinal fasciculus, inferior longitudinal fasciculus, and UF). Pearson correlation and multiple regression analyses were also performed to determine the relationship between the DTT parameters of the temporal white matter projections and the MMSE. An analysis of the correlations showed that the integrity and fiber number of the UF were linked to cognitive performance on the MMSE. In addition, the fiber number of the UF on the MMSE at 6 months from the onset had an explanatory power of 33% and showed the 0.064 for unstandardized coefficients. Using DTT, this study demonstrated that the uncinate fasciculus's fiber number was a strong predictor of cognitive outcomes 6 months post-PH, accounting for 33% of the variance in MMSE scores. Therefore, our findings suggest that early assessment of the UF using DTT may inform prognosis and rehabilitation strategies for PH patients.</p>","PeriodicalId":18549,"journal":{"name":"Medicine","volume":"104 30","pages":"e42728"},"PeriodicalIF":1.4,"publicationDate":"2025-07-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144732233","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Nursing care of patients with acute suppurative appendicitis and perforation in mid pregnancy: A case report.","authors":"Bin Sun, Na Zhang, Xiuying He","doi":"10.1097/MD.0000000000043556","DOIUrl":"10.1097/MD.0000000000043556","url":null,"abstract":"<p><strong>Rationale: </strong>Pregnancy complicated with appendicitis is a common and serious disease, with atypical clinical manifestations and easy confusion of diseases. The prognosis is mainly related to early diagnosis and timely surgical treatment, as well as the gestational age.</p><p><strong>Patient concerns: </strong>This is a patient in mid pregnancy who experienced abdominal pain, high fever for several days, and examination reports indicating acute appendicitis. Due to congestion of pelvic organs and appendix during pregnancy, inflammation developed rapidly, resulting in suppuration and perforation of the appendix, requiring emergency surgery.</p><p><strong>Diagnoses: </strong>The final diagnosis is mid pregnancy, acute suppurative appendiceal perforation.</p><p><strong>Interventions: </strong>Due to the need to alleviate the patient's current symptoms and protect the fetus during pregnancy, emergency surgery is required. During the surgery, the patient's appendix was found to have suppurative perforation and severe infection. After the surgery, a large amount or combination of antibiotics is needed, but the impact of the drugs on the fetus should be considered. Therefore, anti-infection, nutritional support, and fetal protection treatment should be carried out simultaneously.</p><p><strong>Outcomes: </strong>The patient's infection decreased, fever symptoms disappeared and there was no abdominal pain after eating. The fetus was not affected by the disease and was discharged smoothly.</p><p><strong>Lessons: </strong>For pregnant patients, both the patient, and the fetus should be treated and protected simultaneously. By studying this case, we aim to enhance the clinical thinking of nursing staff and improve the quality of nursing service technology.</p>","PeriodicalId":18549,"journal":{"name":"Medicine","volume":"104 30","pages":"e43556"},"PeriodicalIF":1.4,"publicationDate":"2025-07-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144732239","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Pulmonary squamous cell carcinoma with duodenal metastasis: A case report of immunological hyperprogression.","authors":"Qingwang Hua, Zhenyun Ye, Suyue Liu","doi":"10.1097/MD.0000000000043425","DOIUrl":"10.1097/MD.0000000000043425","url":null,"abstract":"<p><p>Immune checkpoint inhibitors have significantly improved the treatment of non-small cell lung cancer by enhancing antitumor immune responses. However, not all patients achieve favorable outcomes. Immune hyperprogression is not uncommon in current adjuvant therapy, but the occurrence of metastatic tumors in the form of hyperprogression when the primary tumor is well controlled has not been reported. This case presents a patient who developed immune hyperprogression (duodenal metastasis) during the immune maintenance phase after surgery. This case underscores the potential for ectopic metastases and hyperprogression during immunotherapy. Clinicians are reminded of the importance of cautious immunotherapy, early identification of HPD, and personalized follow-up in the management of immunotherapy for non-small cell lung cancer.</p>","PeriodicalId":18549,"journal":{"name":"Medicine","volume":"104 30","pages":"e43425"},"PeriodicalIF":1.4,"publicationDate":"2025-07-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144732255","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Unraveling the causal nexus between serum lactate levels and cancer risk: A Mendelian randomization study.","authors":"Lei Yang, Yan Zheng, Faping Li, Jinyu Yu","doi":"10.1097/MD.0000000000043388","DOIUrl":"10.1097/MD.0000000000043388","url":null,"abstract":"<p><p>Lactate, traditionally regarded as a metabolic byproduct, has emerged as a potential signaling molecule involved in tumorigenesis. Although numerous observational studies have linked serum lactate levels to various tumors, establishing a direct causal relationship remains challenging. We conducted a 2-sample Mendelian randomization (MR) analysis using genetic instrumental variables to assess the causal effects of serum lactate levels on the risk of various cancer types. The primary analytical method used in this investigation was the random inverse-variance weighted (IVW) method, supported by auxiliary methods such as MR-Egger, weighted median, simple mode, and weighted mode, with the IVW method enabling the meta-analysis of their combined effects. To obtain exposure data, we extracted genome-wide association studies (GWAS) data on metabolite levels from the Canadian Longitudinal Study on Aging and the UK Biobank cohorts. Concurrently, GWAS data for 17 types of cancer were obtained from the IEU Open GWAS project and the GWAS Catalog project. Sensitivity analyses were performed using the Cochran Q test, MR-Egger intercept test, MR-PRESSO, and the leave-one-out method. Our MR analysis identified a causal relationship between serum lactate and endometrial cancer (odds ratio [OR]IVW = 1.1217, 95% confidence interval [CI] = 1.0264-1.2258, P = .0112), melanoma (ORIVW = 1.0015, 95% CI = 1.0006-1.0024, P = .0010), and prostate cancer (ORIVW = 0.9578, 95% CI = 0.9319-0.9844, P = .0020). Notably, elevated lactate levels were identified as a risk factor for endometrial cancer and melanoma, while having a protective effect against prostate cancer. However, this observed relationship was not replicated in other cancer types. Our study, using GWAS data, establishes a causal link between circulating lactate and the risk of endometrial cancer, melanoma, and prostate cancer. The identification of these associations suggests the potential utility of lactate as a biomarker for these cancers or as a target for cancer prevention strategies.</p>","PeriodicalId":18549,"journal":{"name":"Medicine","volume":"104 30","pages":"e43388"},"PeriodicalIF":1.4,"publicationDate":"2025-07-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144732301","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}