Medicine最新文献

{"title":"Gut microbiota causally affects ulcerative colitis by potential mediation of plasma metabolites: A Mendelian randomization study.","authors":"Shidong Zhao, Xianjing Zheng, Changjiang Yang, Weisong Shen, Zhanlong Shen","doi":"10.1097/MD.0000000000042791","DOIUrl":"https://doi.org/10.1097/MD.0000000000042791","url":null,"abstract":"<p><p>Ulcerative colitis (UC) is a chronic inflammatory bowel disease with a multifactorial etiology, including genetic, immunological, and environmental factors, as well as alterations in the gut microbiome and plasma metabolites. The interplay between these factors is complex and not fully elucidated, particularly regarding the potential mediation of metabolites in the relationship between gut microbiota and UC. We performed a Mendelian randomization (MR) study to investigate the causal associations between gut microbiota, plasma metabolites, and UC. The study utilized a two-sample MR approach to discern causal relationships among these factors. Genetic variants from genome-wide association studies served as instrumental variables in the MR analyses, conducted using the \"TwoSampleMR\" package in R software. We adhered to the fundamental assumptions of MR analyses, ensuring the validity of our causal inferences. Additionally, we incorporated a mediation analysis to assess the potential mediating role of plasma metabolites in the relationship between gut microbiota and UC. Our current study found the substantial relationship between certain gut microbial taxa and the development of UC. Indeed, we have identified 6 microbial taxa, including Genus Dorea, Phylum Proteobacteria, Species Streptococcus parasanguinis, Species Ruminococcus obeum, Species Roseburia intestinalis, and Order Lactobacillales, which were found to be causally related to UC. Seventy-three metabolites and metabolite ratios of were also causally associated with UC, and a mediation analysis revealed that metabolites such as stearoylcarnitine, 3-hydroxyoctanoylcarnitine, 1-arachidonoyl-GPE (20:4n6), 3-(3-hydroxyphenyl)propionate sulfate, and thioproline mediated the effects of gut microbiota on UC and hence might play roles in disease pathogenesis. This microbiota-UC-specific MR study provides evidence for causal associations between specific gut microbiota and UC, potentially mediated through plasma metabolites. The findings give new perspectives on the causal nexus of the gut microbiota and plasma metabolites with UC, highlighting potential intervention targets for the disease. These findings call for confirmation in further research, together with investigation of the underlying mechanisms.</p>","PeriodicalId":18549,"journal":{"name":"Medicine","volume":"104 26","pages":"e42791"},"PeriodicalIF":1.3,"publicationDate":"2025-06-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144528767","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The impact of individuals' self-esteem on cosmetic dermatology preferences assessed using the Rosenberg Self-Esteem Scale: A cross-sectional study.","authors":"Almuntsrbellah Almudimeegh, Eman Almukhadeb, Khalid Nabil Nagshabandi, Naif Alshehri, Hala Abdullah Almusa, Omar Aldosari, Ibrahim Aldakhil","doi":"10.1097/MD.0000000000043109","DOIUrl":"https://doi.org/10.1097/MD.0000000000043109","url":null,"abstract":"<p><p>The pursuit of aesthetic enhancement through cosmetic dermatology has increased globally, influenced by societal beauty standards and social media. Self-esteem plays a pivotal role in shaping individuals' choices for cosmetic dermatology procedures. To examine the relationship between self-esteem and preferences for cosmetic dermatologic procedures among the Saudi population, utilizing the Rosenberg Self-Esteem Scale. A cross-sectional survey was conducted among 919 participants in Saudi Arabia. The modified Arabic version of the Rosenberg Self-Esteem Scale assessed self-esteem levels. Demographic data, skincare habits, and cosmetic procedure preferences were analyzed using χ2 and multivariate regression tests. Low self-esteem was prevalent in 26% of participants and significantly associated with specific skincare habits (e.g., applying routines to hands and neck) and prior cosmetic procedures targeting visible body areas (P < .05). Participants without a history of cosmetic procedures were 1.72 times more likely to exhibit low self-esteem (adjusted odds ratio = 1.718; P = .002), whereas those not planning future procedures showed a decreased likelihood of low self-esteem (adjusted odds ratio = 0.501; P < .001). The study highlights a significant relationship between low self-esteem and increased engagement in cosmetic-seeking behaviors. Understanding these psychological factors can guide practitioners toward more patient-centered care.</p>","PeriodicalId":18549,"journal":{"name":"Medicine","volume":"104 26","pages":"e43109"},"PeriodicalIF":1.3,"publicationDate":"2025-06-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144528785","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Risk factors for developing hypertension in patients with type 2 diabetes: A cross-sectional study.","authors":"Lu Liu, Jie Mu, Xixiang Wang, Yiyao Gu, Shaobo Zhou, Xiaojun Ma, Jingjing Xu, Yu Liu, Xiuwen Ren, Zhi Duan, Linhong Yuan, Ying Wang","doi":"10.1097/MD.0000000000043104","DOIUrl":"https://doi.org/10.1097/MD.0000000000043104","url":null,"abstract":"<p><p>This study explores the prevalence of hypertension in patients with type 2 diabetes mellitus (T2DM) and identifies the potential risk factors associated with the development of hypertension. A cross-sectional study was conducted among 699 T2DM patients. Demographic data and clinical parameters were collected using structured questionnaires and physical examinations. Binary logistic regression was used to assess associations between hypertension and potential risk factors, adjusting for confounders. Body mass index was positively associated with uric acid levels and high-density lipoprotein cholesterol (HDL-c) in the non-hypertensive group. In the hypertensive group, HDL-c was positively correlated with fasting insulin, postprandial insulin, and triglycerides. The primary factors associated with hypertension in patients with T2DM include glycosylated hemoglobin A1C (odds ratio [OR] = 0.54, 95% confidence interval [CI]: 0.32-0.92, P = .02), HDL-c (OR = 0.54, 95% CI: 0.23-0.86, P = .02), education level (OR = 0.44, 95% CI: 0.23-0.82, P = .01), lactate dehydrogenase (OR = 1.01, 95% CI: 1.00-1.02, P = .01), urinary albumin-to-creatinine ratio (OR = 0.97, 95% CI: 0.94-1.00, P = .03), and microalbumin (OR = 1.01, 95% CI: 1.00-1.01, P = .02). Hemoglobin A1c, HDL-c, lactate dehydrogenase, urinary albumin-to-creatinine ratio, microalbumin, and postprandial insulin are critical predictors of hypertension in individuals with T2DM. In conjunction with lifestyle modifications aimed at weight management and glycemic control, regular monitoring of these biomarkers is recommended to prevent hypertension in diabetes management.</p>","PeriodicalId":18549,"journal":{"name":"Medicine","volume":"104 26","pages":"e43104"},"PeriodicalIF":1.3,"publicationDate":"2025-06-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144528799","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Ultrasonic S-Detect mode for the evaluation of thyroid nodules: A meta-analysis: Retraction.","authors":"","doi":"10.1097/MD.0000000000042738","DOIUrl":"https://doi.org/10.1097/MD.0000000000042738","url":null,"abstract":"","PeriodicalId":18549,"journal":{"name":"Medicine","volume":"104 26","pages":"e42738"},"PeriodicalIF":1.3,"publicationDate":"2025-06-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144528811","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Utility of evaluating symptom changes in the patient with patulous Eustachian tube through acoustic assessment: A case report.","authors":"Jin-Kook Lee, Cha Dong Yeo, Myoung-Hwan Ko, Gi-Wook Kim","doi":"10.1097/MD.0000000000043034","DOIUrl":"https://doi.org/10.1097/MD.0000000000043034","url":null,"abstract":"<p><strong>Rationale: </strong>Patulous Eustachian tube (PET) refers to condition where the Eustachian tube remains abnormally open or fails to close adequately, leading to autophony, aural fullness, breathing autophony, tinnitus, and hypernasality. This case study reports the acoustic characteristics of a PET patient with hypernasality evaluate the changes in symptoms before and after conservative therapy, and demonstrate the utility of objective assessment through speech evaluation in addition to subjective symptom assessment.</p><p><strong>Patient concerns: </strong>The 40-year-old female presented to the otolaryngology outpatient clinic with complaints of aural fullness and autophony, tinnitus, hypernasality. Otoscopic examination revealed bilateral adhesive tympanic membranes. Despite bilateral ventilation tube insertion performed to address the persistent aural fullness, the patient continued to experience the same symptoms postoperatively.</p><p><strong>Diagnoses and interventions: </strong>The patient began evaluation and treatment including speech, physical, and drug therapy were performed, for hypernasality, dyspnea, and swallowing problem with the Department of Rehabilitation Medicine. We assessed nasalance, vocal quality, and questionnaire both before and after the treatment. The acoustic data related to PET and the questionnaire results were then obtained.</p><p><strong>Outcomes: </strong>Significant improvements were observed in nasalance and vocal quality, questionnaire. Nasalance and jitter, shimmer metrics, questionnaire results gradually decreased. Notably, jitter and shimmer, questionnaire score, which were outside the normal range in the pretreatment assessment, returned to within normal limits following the conservative treatment.</p><p><strong>Lessons: </strong>Studies focused on PET with hypernasality changes in acoustic data and questionnaire are extremely rare. This case is significant in that not only was PET with hypernasality improved after conservative therapy, but also changes in nasalance, voice quality, and questionnaire were observed.</p>","PeriodicalId":18549,"journal":{"name":"Medicine","volume":"104 26","pages":"e43034"},"PeriodicalIF":1.3,"publicationDate":"2025-06-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144528813","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Laparoscopic treatment of giant ovarian cystic tumors in children: Case report.","authors":"Huashan Zhao, Shumin Zhao, Shisong Zhang, Rui Guo, Hongxiu Xu, Sai Huang, Gang Shen, Yunpeng Zhai","doi":"10.1097/MD.0000000000042920","DOIUrl":"10.1097/MD.0000000000042920","url":null,"abstract":"<p><strong>Rationale: </strong>Ovarian cystic tumors are common in adult women. However, cases of ovarian cystic tumors approximately 30 cm in diameter are rarely reported in adult women and even rarer in children. Here, we report a rare case of a giant ovarian cystic tumor in a 13-year-old girl.</p><p><strong>Patient concerns: </strong>A 13-year-old girl was admitted to hospital with abdominal pain and distension for 7 days. The parents felt anxious about the child's abdominal lesions and requested laparoscopic surgery.</p><p><strong>Diagnoses: </strong>After evaluation at our hospital, abdominal color ultrasound and enhanced computer tomography revealed a large sac-like fluid density shadow with clear edges in the abdomen, approximately 38 cm × 35 cm × 24 cm in size. We performed a laparoscopic resection of the cystic ovarian tumor, which was pathologically confirmed as a benign ovarian tumor.</p><p><strong>Interventions: </strong>Subsequently, laparoscopic exploration revealed a huge cystic tumor originated from the right ovary with a clear boundary between the tumor and the right ovary.</p><p><strong>Outcomes: </strong>Laparoscopic surgery was used to remove the lesion, and the postoperative recovery and follow-up were uneventful.</p><p><strong>Lessons: </strong>Cases of ovarian cystic tumors with a diameter of approximately 30 cm are very rare in pediatric patients. Laparoscopic surgery is an essential method for the diagnosis and treatment of giant ovarian cystic tumors and can be used as a first-line treatment.</p>","PeriodicalId":18549,"journal":{"name":"Medicine","volume":"104 25","pages":"e42920"},"PeriodicalIF":1.3,"publicationDate":"2025-06-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12187354/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144475877","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Predictive models for intrapartum maternal fever: Development and validation of pre-analgesia and labor process indicators.","authors":"Bo Liu, Liang Ling, Dayuan Wei, Yuanling Li, Fei Jia, Huiru Li, Na Li, Hongquan Xiao, Jian Zhang","doi":"10.1097/MD.0000000000042939","DOIUrl":"10.1097/MD.0000000000042939","url":null,"abstract":"<p><p>Combined spinal-epidural anesthesia is effective for labor pain relief but is associated with increased rates of intrapartum maternal fever, which can negatively impact maternal and neonatal outcomes. This study aimed to develop and validate 2 predictive models: one to assess the risk of fever before labor analgesia (model B) and another to evaluate the risk of fever throughout the labor process (model W). This retrospective case-control study was conducted at Chengdu Jinjiang District Maternal & Child Health Hospital, including 2783 parturients who received labor analgesia between January 2021 and March 2022. Stepwise logistic regression was used to identify clinical predictive indicators, followed by multivariate logistic regression to determine intrapartum fever predictors. Model performance was assessed using the Hosmer-Lemeshow test and areas under the receiver operating characteristic curves (AUROCs). A total of 2276 patients were included in the development cohort and 507 in the validation cohort. Optimal predictors for model B included primiparity, neutrophil count, anemia, estimated fetal weight, body surface area, and cervical dilation before analgesia. For model W, predictors included height, primiparity, anemia, neutrophil count, estimated fetal weight, total duration of labor, and time from rupture of membranes to delivery. AUROCs for models B and W were 0.698 and 0.740, respectively; external validation showed AUROCs of 0.703 and 0.797. In conclusion, model B effectively predicts fever risk before labor analgesia, though its predictive efficiency is lower than model W, which better predicts fever risk after analgesia. The combination of these 2 models will aid in the early identification and management of high-risk parturients, thereby reducing the incidence of intrapartum fever and improving maternal and neonatal outcomes.</p>","PeriodicalId":18549,"journal":{"name":"Medicine","volume":"104 25","pages":"e42939"},"PeriodicalIF":1.3,"publicationDate":"2025-06-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12187268/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144475900","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Autoimmune diseases and diffuse large B-cell lymphoma: A Mendelian randomization study.","authors":"Jiaying Duan, Litian Ma, Tianhao Wang, Tian Li, Yu Li","doi":"10.1097/MD.0000000000042855","DOIUrl":"10.1097/MD.0000000000042855","url":null,"abstract":"<p><p>The causal link between autoimmune diseases (ADs) and diffuse large B-cell lymphoma (DLBCL) remains uncertain. This study aims to assess the causal effects of ADs on DLBCL risk using Mendelian randomization (MR). The summary dataset for ADs and lymphoma genome-wide association study (GWAS) was sourced from the open GWAS website. Single nucleotide polymorphisms were chosen as genetic instrumental variants based on linkage disequilibrium with P < 5 × 10-8 and R2 = 0.01 in different ADs GWAS. Palindrome and outlier single nucleotide polymorphisms were excluded. Cochran Q test, the MR-EGGER intercept test, MR-PRESSO, and leave-one-out analysis were used to assess sensitivity. Our results showed genetic liability to 6 ADs, including mixed connective tissue disease (odds ratios, ORWM1.578; 95% confidence intervals [CI]: 1.250-1.991, P < .001), psoriasis (ORMR-Egger = 0.775; 95% CI: 0.604-0.992, P = .049), Sjögren syndrome (ORIVW = 1.290; 95% CI: 1.072-1.551, P = .007), systemic lupus erythematosus (ORIVW = 1.153; 95% CI: 1.053-1.262, P = .002), type 1 diabetes mellitus (ORIVW = 0.899; 95% CI: 0.862-0.938, P < .001), and ulcerative colitis (ORMR-Egger = 1.648; 95% CI: 1.210-2.243, P = .003) may have a causal relationship with DLBCL. Our MR results showed that ADs, such as Sjögren syndrome and systemic lupus erythematosus, may have causal relationship with DLBCL, while type 1 diabetes mellitus could reduce the risk of DLBCL.</p>","PeriodicalId":18549,"journal":{"name":"Medicine","volume":"104 25","pages":"e42855"},"PeriodicalIF":1.3,"publicationDate":"2025-06-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12187306/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144475918","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Bibliometric analysis of immunotherapy in treatment of uveal melanoma.","authors":"Wei Chen, Hui Zhang, Dan Xiao, Mengtian Bai, Yumei Luo, Xin Li, Bo Long","doi":"10.1097/MD.0000000000042932","DOIUrl":"10.1097/MD.0000000000042932","url":null,"abstract":"<p><p>Bibliometric analysis is a well-established method for evaluating published research and identifying emerging trends in scientific fields. While recent years have witnessed a surge of research on immunotherapy for uveal melanoma (ITFUM), a comprehensive bibliometric assessment of this domain is lacking. This study aims to conduct a thorough bibliometric analysis to examine the current state, areas of interest, and emerging trends in ITFUM research. A comprehensive collection of 418 publications on ITFUM, sourced from the Web of Science database between January 1, 2000 and May 10, 2024, was analyzed. Employing various bibliometric tools, including HisCite, VOSviewer, CiteSpace, and the bibliometrix package, the study examined data on countries, institutions, authors, journals, references, and keywords. The United States emerged as the leading contributor, accounting for 147 (35.17%) of the published articles. Leiden University was the most productive institution, with 24 (5.74%) publications. The author with the highest publication output was Jager, Martine J. with 15 (3.59%) publications. The journal Cancers demonstrated the highest productivity, with 37 (8.85%) articles. The trend topics between 2023 and 2024 have been identified as \"gene,\" \"proton-beam therapy,\" and \"inhibitor.\" This comprehensive bibliometric analysis provides valuable insights into the current state, collaborative efforts, and future research directions in the field of ITFUM. Further research is needed to identify comprehensive biomarkers and enhance our understanding of the interactions between uveal melanoma cells and infiltrating immune cells. Additionally, efforts should focus on increasing M1-type tumor-associated macrophages, promoting dendritic cells maturation, inhibiting NKT cells, activating NK cells, and refining dendritic cells vaccines and T cell adoptive therapies.</p>","PeriodicalId":18549,"journal":{"name":"Medicine","volume":"104 25","pages":"e42932"},"PeriodicalIF":1.3,"publicationDate":"2025-06-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12187297/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144475919","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Diagnosis of Cushing's syndrome with generalized linear model and development of mobile application.","authors":"Mustafa Aydemir, Mustafa Çakir, Okan Oral, Mesut Yilmaz","doi":"10.1097/MD.0000000000042910","DOIUrl":"10.1097/MD.0000000000042910","url":null,"abstract":"<p><strong>Background: </strong>Cushing syndrome (CS) is a rare endocrine disorder characterized by excessive secretion of glucocorticoids, leading to a variety of clinical manifestations, comorbidities, and increased mortality despite treatment. Despite advances in imaging modalities and biochemical testing, the diagnosis and management of CS remains challenging. Several tests are used to confirm the diagnosis of CS, including urinary free cortisol measurements, dexamethasone suppression tests (1 mg, 2 mg, and 8 mg), and nocturnal salivary cortisol measurements. However, each of these tests has some limitations, making the diagnosis of CS.</p><p><strong>Methods: </strong>In this paper, we explore the potential of state-of-the-art machine learning algorithms as a clinical decision support system for analyzing and classifying CS. Our aim is to use advanced machine learning methods to analyze the accuracy rates of diagnostic tests and identify the most sensitive tests for diagnosing CS.</p><p><strong>Results: </strong>In this study, we performed binary classification based on data from 278 patients with CS (CS+) and 220 healthy patients (CS-). We developed a linear mathematical model with high predictive ability, achieving a classification accuracy of 97.03% and a Kappa value of 94.05%. The correlation graph shows that CS has strong positive relationships with 2 mg (78.8%), 1 mg (76.9%), and mc (72.1%), and moderate positive correlations with 8 mg (45%) and saliva (45.4%). In contrast, gender has almost no correlation with CS, so it was removed from the dataset. As a result, the model achieves an overall classification accuracy of 97.03%. Finally, we converted the linear model into a mobile application for use by specialist doctors in the field of endocrinology.</p><p><strong>Conclusion: </strong>Traditional diagnostic methods can be time-consuming and require specialized medical expertise. Recently, advances in machine learning and mobile technology have opened new avenues for improving diagnostic accuracy and accessibility. This study explores the integration of machine learning algorithms into a mobile application designed to assist healthcare professionals and patients in the diagnosis of CS.</p>","PeriodicalId":18549,"journal":{"name":"Medicine","volume":"104 25","pages":"e42910"},"PeriodicalIF":1.3,"publicationDate":"2025-06-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12187266/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144475932","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}