Medicine最新文献

{"title":"Current status of anxiety following total hysterectomy in endometrial cancer patients: A cross-sectional study.","authors":"Jing Yang, Huan Liang, Hongcheng Zhu, Hongmei Xiang, Xiaoling Liu, Hua Xiao, Ting Yang","doi":"10.1097/MD.0000000000041782","DOIUrl":"10.1097/MD.0000000000041782","url":null,"abstract":"<p><p>The aim of this study was to evaluate the prevalence of anxiety in endometrial cancer patients undergoing total hysterectomy and to analyze socio-demographic and clinical factors contributing to anxiety, with the goal of informing targeted psychological support and interventions in clinical settings. The study employed a cross-sectional survey design, including 74 patients who underwent total hysterectomy between January 2019 and January 2024 at our hospital. Data were collected through a combination of face-to-face interviews and self-administered questionnaires, conducted by specially trained research assistants or nurses to ensure standardized data collection. Anxiety levels were assessed using the Self-Assessment Scale for Anxiety, categorizing patients into no anxiety, mild anxiety, moderate anxiety, and severe anxiety based on standard scores. Results indicated that 33.78% of the 74 patients experienced varying levels of anxiety: 18.92% had mild anxiety, 12.16% had moderate anxiety, and 2.70% had severe anxiety. Univariate analysis showed significant associations between anxiety and factors such as education level, living arrangement, social support, tumor size, and International Federation of Gynaecology and Obstetrics (FIGO) stage. Multivariate logistic regression analysis further confirmed that low education level (OR = 1.866, P = .014), unstable living conditions (OR = 2.285, P = .016), inadequate social support (OR = 2.806, P = .044), larger tumor size (OR = 3.328, P = .021), and advanced FIGO stage (OR = 3.762, P = .01) were independent predictors of postoperative anxiety. This study revealed a high prevalence of anxiety among postoperative endometrial cancer patients and identified key influencing factors, including low educational attainment, unstable living arrangements, insufficient social support, larger tumors, and advanced disease stage. These findings underscore the importance of healthcare professionals focusing on high-risk groups to effectively reduce anxiety, improve mental health, and enhance quality of life. Strategies such as enhanced health education, establishment of support groups, provision of psychological counseling, and comprehensive mental health assessments are recommended to address the psychological needs of these patients.</p>","PeriodicalId":18549,"journal":{"name":"Medicine","volume":"104 12","pages":"e41782"},"PeriodicalIF":1.3,"publicationDate":"2025-03-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11936620/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143700681","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Dynamic evaluation of postoperative survival in pancreatic ductal adenocarcinoma.","authors":"Bo-Wen Zheng, Xin-Yu Yang, Jun Zheng, Ru-Cheng Yao","doi":"10.1097/MD.0000000000041942","DOIUrl":"10.1097/MD.0000000000041942","url":null,"abstract":"<p><p>The pancreatic ductal adenocarcinoma has a high degree of malignancy, and traditional prognostic assessment methods have limited evaluative capacity. This study is based on the Kallikrein-related peptidase 7 (KLK7) expression and uses conditional survival algorithms to perform dynamic survival assessments of patients. The Cox proportional hazards model was employed for identifying and adjusting for potential confounders. The Kaplan-Meier technique was utilized to estimate the overall survival rate. The computation of the likelihood of patients surviving an additional year after X years of survival was achieved using the equation CS1 = OS(X + 1)/OS(X). A subgroup analysis based on CS1 was conducted for each individual risk factor. A total of 243 eligible patients were included in the study. Conditioned survival (CS) refers to the years a patient has already survived and the predicted years they are likely to survive in the future, while conducting a time-varying analysis of the factors influencing prognosis. The survival probability assessed by CS1 increased year by year, with the 1-, 2-, and 3-year survival rates rising from 50.4% to 91.2%. In contrast, the actuarial overall survival (OS) decreased from 81.9% at 1 year to 38.6% at 3 years post-surgery. The results of the conditional analysis indicate that patients who survive longer within a certain timeframe have better survival expectations in the future. Adverse factors, including KLK7, have a decreasing impact on survival over time. Conditional survival analysis based on KLK7 can provide more accurate survival predictions for patients who has identified KLK7.</p>","PeriodicalId":18549,"journal":{"name":"Medicine","volume":"104 12","pages":"e41942"},"PeriodicalIF":1.3,"publicationDate":"2025-03-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11936588/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143700705","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A retrospective study on the predictive efficacy of SOBDA and VSRQ scales for prognosis in elderly COPD patients.","authors":"Qihui Hu, Jie Chen, Shengqi Li","doi":"10.1097/MD.0000000000041857","DOIUrl":"10.1097/MD.0000000000041857","url":null,"abstract":"<p><p>This retrospective study aimed to compare the predictive efficacy of the shortness of breath with daily activities (SOBDA) and ventilatory response to exercise questionnaire (VSRQ) in forecasting respiratory-related adverse events in elderly patients with chronic obstructive pulmonary disease (COPD) over a 6-month follow-up period post-discharge. A total of 92 COPD patients, treated according to the 2022 GOLD report and Chinese National COPD treatment guidelines, were enrolled. SOBDA and VSRQ scores were collected upon admission and assessed daily for the first 7 days. A random forest model was used to evaluate the predictive value of these scores in relation to respiratory adverse events, with a training/testing group split at a 4:1 ratio. Five patients were excluded due to loss to follow-up or death, resulting in 87 patients in the final analysis. The primary endpoint was the occurrence of COPD exacerbations and respiratory failure. The random forest model using VSRQ scores as the response variable outperformed the SOBDA model in terms of predictive accuracy (AUC: 0.84 vs 0.65) and error rate (21.74% vs 22%). Both models demonstrated high accuracy in predicting the absence of adverse events (VSRQ: 85.72%, SOBDA: 83.67%) but showed limited sensitivity in predicting their occurrence (VSRQ: 35%, SOBDA: 40%). The VSRQ questionnaire demonstrated superior predictive performance compared to SOBDA, suggesting that VSRQ may be a useful tool for identifying high-risk elderly COPD patients and guiding clinical decision-making. Further studies are needed to confirm these findings and explore the broader applicability of VSRQ in COPD prognosis.</p>","PeriodicalId":18549,"journal":{"name":"Medicine","volume":"104 12","pages":"e41857"},"PeriodicalIF":1.3,"publicationDate":"2025-03-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11936576/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143700890","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Neurological manifestations of Erdheim-Chester disease and their management: A scoping review.","authors":"Muhammad Saeed Qazi, Awais Ahmad, Mahreen Mukhtiar, Rizwana Noor, Hassan Ahmed, Shifa Ul Mehmood, Maryam Abbasi, Amna Siddiqui, Muhammad Hasanain, Zain Ul Abideen, Mohammed Mahmmoud Fadelallah Eljack","doi":"10.1097/MD.0000000000041932","DOIUrl":"10.1097/MD.0000000000041932","url":null,"abstract":"<p><strong>Background: </strong>Erdheim-Chester disease (ECD) is characterized by the excessive production and accumulation of histiocytes, particularly foamy histiocytes encircled by fibrosis, in various organs. ECD can affect a person's long bones, skin, lungs, brain, heart, and other tissues and organs.</p><p><strong>Methods: </strong>In February 2024, we conducted a thorough literature search on main databases to find studies published between 2021 and 2024. We used keywords like \"ECD CNS,\" \"ECD Neuro,\" \"Erdheim Chester Disease CNS,\" \"histiocytosis,\" and \"Erdheim Chester Disease Neurology.\" We first produced 461 articles and then limited the selection process to 29 articles using an English language filter and an abstract analysis. In the end 16 articles were added in the review on ECD with neurological symptoms.</p><p><strong>Results: </strong>Ataxia, cranial neuropathies, and cognitive impairment were the main clinical findings. Histopathology showed that 88% of the cases had histiocyte infiltrates with CD68 + histiocytes, 50% had a BRAF mutation, and 83.3% had an expanding mass. The most common treatment was vemurafenib, followed by steroids, surgery, and chemotherapy. Results revealed 15.78% mortality, 26.31% progression, and 31.57% improvement or stabilization. In most cases, steroid medication proved useless; however, vemurafenib and radiation therapy helped some patients' symptoms.</p><p><strong>Conclusion: </strong>An early diagnosis of the disease is important for timely intervention, to prevent fatal outcomes. Vemurafenib was the only drug which proved its efficacy against the disease, as compared to other drugs. This study presents valuable insights for the neurology of ECD and highlights the benefits of a comprehensive management for this complex condition.</p>","PeriodicalId":18549,"journal":{"name":"Medicine","volume":"104 12","pages":"e41932"},"PeriodicalIF":1.3,"publicationDate":"2025-03-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11936638/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143700903","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Influence of infrapatellar fat pad size on the development and severity of chondromalacia patella.","authors":"Sercan Capkin, Ali Ihsan Kilic, Zeynep Ayvat Ocal, Mehmet Akdemir, Mahmud Aydin, Mert Kahraman Marasli","doi":"10.1097/MD.0000000000041930","DOIUrl":"10.1097/MD.0000000000041930","url":null,"abstract":"<p><p>The inflammatory role of the infrapatellar fat pad (IPFP) in cartilage damage has been well-documented, yet its potential protective function as a shock absorber remains underexplored. This retrospective cohort study aimed to evaluate the relationship between the IPFP size and chondromalacia patella (CP), while also examining the effects of age, sex, and body mass index (BMI). Magnetic resonance imaging scans from 311 patients aged 40 to 65 years were retrospectively analyzed. Axial sequences classified CP severity, and sagittal sequences measured IPFP areas. CP was graded according to the International Cartilage Repair Society system, and patients were grouped into control (no CP), mild CP (grades 1-2), and severe CP (grades 3-4) categories. Demographic data, including age, sex, and BMI, were collected, and statistical analysis explored the relationships between IPFP area, CP severity, and these factors. Of the patients, 145 (46.6%) had no CP, while 166 (53.4%) had varying CP severity. Patients with CP had significantly smaller IPFP areas (6.16 ± 0.67 cm2) compared to controls (6.96 ± 0.87 cm2, P < .001). The mean IPFP area decreased progressively with increasing CP severity. After adjusting for confounders, a smaller IPFP area was significantly associated with the presence and severity of CP (P < .001). These findings provide evidence that a larger IPFP area plays a protective role in maintaining patellar cartilage integrity and mitigating CP progression, as demonstrated by a significant inverse correlation between IPFP area and CP severity, independent of age, sex, and BMI. A comprehensive, multidisciplinary approach integrating biomechanical, metabolic, and inflammatory factors is warranted to fully elucidate the role of IPFP in CP.</p>","PeriodicalId":18549,"journal":{"name":"Medicine","volume":"104 12","pages":"e41930"},"PeriodicalIF":1.3,"publicationDate":"2025-03-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11936608/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143700911","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Assessment of age using physiological methods: dentin deposition versus tooth wear: A cross-sectional study.","authors":"Aashima Gupta, Nitin Kudyar, Prashant Nahar, Mohit Pal Singh, Shahabe Saquib Abullais, Shaik Mohamed Shamsudeen, Shafait Ullah Khateeb, Sadatullah Syed","doi":"10.1097/MD.0000000000041938","DOIUrl":"10.1097/MD.0000000000041938","url":null,"abstract":"<p><p>Age is a crucial factor in identifying a person in forensic medicine. Dentition is one of the physiological indicators of chronological age. Radiographic dental age assessment is a simple, noninvasive and reproducible method. Age estimation is also done by evaluating tooth wear. To assess and compare morphological parameters of maxillary central incisors evaluated on radiographs using Kvaal's method with occlusal wear of posterior teeth using Kim's method in age estimation. A total of 50 individuals from 20 to 70 years of both genders were included. Radiographic analysis and occlusal tooth wear were calculated based on Kvaal's method and Kim's scoring criteria, respectively. The mean predicted age of the patient through radiographic analysis by Kvaal's method was 44.762. In contrast, the mean predicted age through occlusal tooth wear analysis of posterior teeth by Kim's scoring system was 44.842. Furthermore, the difference from the population mean age was 0.002 for radiographic analysis by Kvaal's method and 0.081 by occlusal tooth wear analysis by Kim's system. The result infers radiographic analysis by Kvaal's method was more accurate than occlusal tooth wear analysis by Kim's system in age estimation.</p>","PeriodicalId":18549,"journal":{"name":"Medicine","volume":"104 12","pages":"e41938"},"PeriodicalIF":1.3,"publicationDate":"2025-03-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11936545/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143700915","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association between gamma-glutamyl transferase and diabetes factors among elderly nonobese individuals.","authors":"Chih-Tsueng He, Fang-Yu Chen, Chun-Heng Kuo, Chung-Yu Lin, Dee Pei, Pietro Pitrone, Jin-Shuen Chen, Chung-Ze Wu","doi":"10.1097/MD.0000000000041913","DOIUrl":"10.1097/MD.0000000000041913","url":null,"abstract":"<p><p>Type 2 diabetes mellitus is a significant health concern among elderly individuals in Taiwan, and liver dysfunction, particularly nonalcoholic fatty liver disease, is prevalent in this population. Gamma-glutamyl transferase (γ-GT), a key enzyme involved in glutathione metabolism, has been linked to metabolic disorders, including insulin resistance (IR) and diabetes. However, its association with insulin secretion phases (first-phase insulin secretion, FPIS; second-phase insulin secretion, SPIS) and glucose effectiveness (GE) remains unclear. This study aimed to investigate these relationships in elderly nonobese Chinese individuals. A total of 10,933 participants (5082 men and 5851 women) aged ≥ 65 years were enrolled. Participants were classified based on metabolic syndrome (MetS) status and γ-GT quartiles. Blood samples were analyzed for γ-GT, fasting plasma glucose, insulin resistance, and lipid profiles. The study used established equations to calculate IR, FPIS, SPIS, and GE. Pearson correlation analysis and statistical models were applied to assess the associations. 768 men and 794 women had MetS. Those with MetS had higher IR, FPIS, SPIS, γ-GT levels, and lower GE. Higher γ-GT levels were significantly associated with MetS components and increased IR, FPIS, SPIS, and decreased GE. GE had the strongest negative correlation (r = -0.198 for men, -0.158 for women), followed by positive correlations with IR (r = 0.183 for men, 0.132 for women), SPIS (r = 0.099 for men, 0.060 for women), and FPIS (r = 0.028 for men, 0.048 for women). γ-GT was positively associated with IR, FPIS, and SPIS but negatively correlated with GE in elderly individuals. Among the 4 diabetes factors, GE exhibited the strongest correlation with γ-GT, followed by IR, SPIS, and FPIS. These findings highlight the need for further research into the role of γ-GT in glucose metabolism and potential clinical implications for elderly nonobese Chinese populations.</p>","PeriodicalId":18549,"journal":{"name":"Medicine","volume":"104 12","pages":"e41913"},"PeriodicalIF":1.3,"publicationDate":"2025-03-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11936563/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143700916","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Measurement of serum adropin levels in chronic renal failure patients receiving routine hemodialysis treatment.","authors":"Adil Furkan Kiliç, Edip Erkuş, Lale Duysak","doi":"10.1097/MD.0000000000041860","DOIUrl":"10.1097/MD.0000000000041860","url":null,"abstract":"<p><p>The significance of adropin levels in chronic renal failure patients has not yet been established. This study's objectives were to compare serum adropin levels in hemodialysis patients with chronic renal failure and healthy patients as well as the clinical parameters corresponding with the levels. The total sample comprised of 49 hemodialysis individuals and 36 controls. We measured serum adropin concentrations using enzyme-linked immunosorbent assay method and analyzed various biochemical parameters including creatinine, uric acid, C-reactive protein, albumin, parathyroid hormone, and hemoglobin levels. In the patients there were statistically significant lower levels of serum adropin determined at 522.7 ± 169.4 versus 789.6 ± 259.3 ng/L, P < .01. Strong negative correlations were observed between adropin levels and both creatinine (r = -0.613, P < .001) and parathyroid hormone (r = -0.621, P < .001). Additionally, moderate positive correlations were found with albumin (r = 0.534, P < .001) and hemoglobin (r = 0.445, P < .001). There were also statistically significant differences in hemoglobin A1c of the patients and control populations with levels of 5.7 ± 1.8 versus 5.2 ± 0.5, P = .04 and C-reactive protein levels of 21.8 ± 28.9 versus 1.4 ± 2.6 mg/L, P < .01 respectively. These findings suggest that reduced adropin levels in hemodialysis patients are significantly associated with markers of renal dysfunction, inflammation, and nutritional status, indicating its potential role in the pathophysiology of chronic renal failure.</p>","PeriodicalId":18549,"journal":{"name":"Medicine","volume":"104 12","pages":"e41860"},"PeriodicalIF":1.3,"publicationDate":"2025-03-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11936645/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143700929","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"One-stage urethroplasty using a combination of buccal mucosa graft and Q penile skin flap for a complicated urethral stricture: A challenging case report.","authors":"Abdulrazak Anadani, Aya Obaidin, Bashar Badawi, M Yasin Lutfi","doi":"10.1097/MD.0000000000041888","DOIUrl":"10.1097/MD.0000000000041888","url":null,"abstract":"<p><strong>Rationale: </strong>Strictures of the male urethra are common, often caused by trauma or occur idiopathically. The primary clinical symptoms include chronic obstructive voiding issues, and some patients may experience sexual dysfunction. Treatment choices mainly depend on the stricture's location and length.</p><p><strong>Patient concerns: </strong>A 37-year-old man visited the urology department with lower urinary tract symptoms and recurrent urinary tract infections. He had a 5 cm urethral stricture previously treated with urethroplasty, which was unsuccessful.</p><p><strong>Diagnoses: </strong>A retrograde urethrography revealed the stricture, an extra-anatomical bypass, and a diverticulum.</p><p><strong>Interventions: </strong>A second urethroplasty was performed, using a combination of a buccal mucosa graft and a penile skin flap.</p><p><strong>Outcomes: </strong>Postoperative follow-up indicated improvement in the patient's voiding symptoms. A retrograde urethrography was done 3 months after the procedure showing a well-patent urethra with no complications.</p><p><strong>Lessons: </strong>The key factors in deciding the treatment for urethral strictures are their location and length. Both grafts and flaps are effective for urethroplasties. However, complex long strictures with damaged urethral plates pose challenges for successful single-stage reconstruction. Combining a dorsal buccal mucosa graft to augment the urethral plate with a ventral onlay penile skin flap is a promising approach, leveraging the benefits of both tissue types. Combining grafts and flaps is advisable for reconstructing complicated urethral strictures with damaged urethral plates. Consulting a more experienced surgeon is recommended to minimize the risk of complications.</p>","PeriodicalId":18549,"journal":{"name":"Medicine","volume":"104 12","pages":"e41888"},"PeriodicalIF":1.3,"publicationDate":"2025-03-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11936549/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143700945","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The clinical characteristics differences between IVF twins and naturally conceived twins with preterm infants.","authors":"Chunyan Guo, Shasha Li, Jingcai Wang, Yanqiu Wu","doi":"10.1097/MD.0000000000041884","DOIUrl":"10.1097/MD.0000000000041884","url":null,"abstract":"<p><p>With the rapid development of Assisted Reproductive Technology, in vitro fertilization (IVF) has become one of the most important treatments for infertility. However, the widespread use of IVF has significantly increased the incidence of twin pregnancies, which in turn raises the risk of preterm twin births. Twin pregnancies are inherently high-risk, often associated with complications such as preterm labor, fetal growth restriction, and congenital malformations, all of which can severely impact the health of both mothers and infants. The aim of this study is to investigate the differences between IVF twin preterm infants and naturally conceived twin preterm infants. In this study, we included 144 cases of twin preterm infants born in the obstetrics department of our hospital and subsequently transferred to the neonatal unit between January 2021 and June 2024. Using a retrospective cohort design, we divided the cases into 2 groups: 72 IVF-embryo transfer cases (observation group) and 72 naturally conceived cases (control group). We compared the 2 groups in terms of general characteristics, mode of delivery, premature rupture of membranes, congenital heart disease, intracranial hemorrhage, neonatal conditions, and hospitalization to assess the impact of IVF on twin preterm infants and maternal perinatal diseases. The results showed that the observation group had a significantly higher proportion of assisted perineal lateral incisions, a higher incidence and longer duration of premature rupture of membranes (P < .05), and a higher incidence of atrial septal defect (P < .05) compared to the control group. Additionally, the incidence of neonatal hyperbilirubinemia, intracranial hypertension syndrome, and hypocalcemia was significantly higher in the observation group (P < .05), whereas the incidence of twin-twin transfusion syndrome was significantly lower (P < .05). During hospitalization, the observation group required enteral and intravenous nutrition for a significantly longer period than the control group (P < .05). Regarding maternal characteristics, the observation group had a higher maternal age, a greater proportion of primigravida, and significantly higher rates of hypothyroidism during pregnancy and antenatal antibiotic use compared to the control group (P < .05). In conclusion, IVF twin preterm infants exhibited significant differences in clinical characteristics and maternal perinatal disorders when compared to naturally conceived twin preterm infants. This suggests that IVF technology may present additional clinical management challenges while enabling twin pregnancies.</p>","PeriodicalId":18549,"journal":{"name":"Medicine","volume":"104 12","pages":"e41884"},"PeriodicalIF":1.3,"publicationDate":"2025-03-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11936628/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143700963","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}