Medicine最新文献

{"title":"Comparison of the efficacy between Super-Path and Watson-Jones approaches in the management of early femoral head necrosis.","authors":"Yong Xu, Ping Zeng","doi":"10.1097/MD.0000000000041391","DOIUrl":"10.1097/MD.0000000000041391","url":null,"abstract":"<p><p>This study compares and investigates the efficacy of 2 different surgical methods for early stage femoral head necrosis and analyze the factors affecting surgical outcomes and long-term femoral head survival. A retrospective analysis was conducted on the clinical data of 48 patients (52 hips) with femoral head necrosis who underwent either the Super-Path or Watson-Jones approach from January 1, 2016, to January 1, 2024. Harris scores at multiple time points before and after surgery were compared using repeated-measures analysis of variance (ANOVA), and a COX proportional hazards model was used to analyze risk factors. The baseline data of the 2 groups were comparable (P > .05). There was no significant difference in preoperative Harris scores or scores at 3 and 12 months postoperatively (t = 0, P = 1; t = 0.719, 0.476; P = .716, .477). However, a significant difference was found at 36 months postoperatively (t = 2.118, P = .04). The preoperative stage of femoral head necrosis, patient gender, and surgical method were significant risk factors. The survival curves showed similar survival rates for the first 10 months, with no significant difference at 36 months (P = .5139). Both surgical approaches were effective in improving short-term hip function but did not show sustained long-term improvement. The Super-Path approach demonstrated better long-term outcomes compared to the Watson-Jones approach, influenced by surgical and temporal factors and preoperative staging. The COX model indicated that preoperative staging, female gender, and the surgical procedure were positively correlated with the risk of femoral head necrosis.</p>","PeriodicalId":18549,"journal":{"name":"Medicine","volume":"104 4","pages":"e41391"},"PeriodicalIF":1.3,"publicationDate":"2025-01-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11771660/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143033673","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Construction of a prognostic signature based on T-helper 17 cells differentiation-related genes for predicting survival and tumor microenvironment in head and neck squamous cell carcinoma.","authors":"Shiqin Chen, Pingcun Wei, Gang Wang, Fan Wu, Jianjun Zou","doi":"10.1097/MD.0000000000041273","DOIUrl":"10.1097/MD.0000000000041273","url":null,"abstract":"<p><p>T-helper 17 (Th17) cells significantly influence the onset and advancement of malignancies. This study endeavor focused on delineating molecular classifications and developing a prognostic signature grounded in Th17 cell differentiation-related genes (TCDRGs) using machine learning algorithms in head and neck squamous cell carcinoma (HNSCC). A consensus clustering approach was applied to The Cancer Genome Atlas-HNSCC cohort based on TCDRGs, followed by an examination of differential gene expression using the limma package. Machine learning techniques were utilized for feature selection and model construction, with validation performed using the GSE41613 cohort. The interplay between the predictive marker, immune landscape, immunotherapy response, drug sensitivity, and clinical outcomes was assessed, and a nomogram was constructed. Functional evaluations of TCDRGs were conducted through colony formation, transwell invasion, and wound healing assays. Two distinct HNSCC subtypes with significant differences in prognosis were identified based on 87 TCDRGs, indicating different levels of Th17 cell differentiation. Thirteen differentially expressed TCDRGs were selected and used to create a risk signature, T17I, using the random survival forest algorithm. This signature was associated with grade, chemotherapy, radiotherapy, T stage, and somatic mutations. It was revealed that there were differences in the immune response-related pathways between the high- and low-risk groups. Inflammatory pathways were significantly activated in the low-risk group. The T17I signature was associated with immune infiltration. Specifically, there was a higher infiltration of immune activation cells in the low-risk group, whereas the high-risk group had a higher infiltration of M2 macrophages. In addition, the T17I signature was significantly associated with drug sensitivity. A nomogram combining age, radiotherapy, and the T17I signature accurately predicted the prognosis of patients with HNSCC. Finally, in vitro experiments confirmed that knockdown of LAT gene expression promotes proliferation, metastasis, and invasion of HNSCC cells. In conclusion, this study successfully identified molecular subtypes and constructed a prognostic signature and nomogram based on TCDRGs in HNSCC, which may aid in personalized treatment strategies.</p>","PeriodicalId":18549,"journal":{"name":"Medicine","volume":"104 4","pages":"e41273"},"PeriodicalIF":1.3,"publicationDate":"2025-01-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11771614/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143033697","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The roles of STAT1, CASP8, and MYD88 in the care of ischemic stroke.","authors":"Xiaolu Qin, Shuaimin Li, Xinyu Huang","doi":"10.1097/MD.0000000000041396","DOIUrl":"10.1097/MD.0000000000041396","url":null,"abstract":"<p><p>Ischemic stroke is caused by blockage of blood vessels in brain, affecting normal function. The roles of Signal Transformer and Activator of Transcription 1 (STAT1), CASP8, and MYD88 in ischemic stroke and its care are unclear. The ischemic stroke datasets GSE16561 and GSE180470 were found from the Gene Expression Omnibus database. Batch effect removal, finding differentially expressed genes (DEGs), weighted gene co-expression network analysis, protein-protein interaction analysis, functional enrichment analysis, immune infiltration analysis, comparative toxicogenomics database analysis were carried out. Gene expression heat maps were drawn, and miRNAs were found that regulate core DEGs. A total of 1183 DEGs were obtained, which were mainly concentrated in immune effector processes, cell activation, and protein serine/threonine kinase activity, the NOD-like receptor signaling pathway, NF-kappa B signaling pathway, C-type lectin receptor signaling pathway, and P53 signaling pathway. Four core genes were identified. Heatmap revealed high expression of (CASP8, MYD88, and STAT1) in whole blood samples of ischemic stroke. Comparative toxicogenomics database analysis demonstrated (CASP8, MYD88, and STAT1) are related to cerebral hemorrhage, reperfusion injury, hypertension, and inflammation. In ischemic stroke, expression of STAT1, CASP8, and MYD88 is higher and leads to poorer prognosis.</p>","PeriodicalId":18549,"journal":{"name":"Medicine","volume":"104 4","pages":"e41396"},"PeriodicalIF":1.3,"publicationDate":"2025-01-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11771608/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143033572","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Investigating the relationship between social media use and the attitudes towards nutrition and body image shame among Iranian female students: A cross-sectional study.","authors":"Sogol Keyvanpour, Masoumeh Namazi, Fatemeh Hosseini, Narges Ebrahimi","doi":"10.1097/MD.0000000000041383","DOIUrl":"10.1097/MD.0000000000041383","url":null,"abstract":"<p><p>Social media are Internet-based services that allow participation in online communities and exchanges. Considering the high and increasing statistics of the use of social media all over the world and its impact on people's lives, the present study aimed to determine the relationship between social media and nutritional attitudes and body image shame among Iranian female students. This cross-sectional study was performed on 201 female student of Tehran University of Medical Sciences in Tehran, Iran from May to December 2023. Data collection was done using a paper form. Data collection tools included a questionnaire on demographic information, Jahanbani social media use questionnaire, nutrition attitude questionnaire (EAT-26), and Body Image Shame Questionnaire (BISS). SPSS software version 28 was used for the descriptive analysis of the data, to examine the relationships between the studied variables, and to measure and evaluate the accuracy of the AMOS model. Based on the reported results, the indicator of social media usage had a significant and positive direct effect on the attitude towards nutrition of students (P < .05). Additionally, social media usage had a significant and positive direct effect on the indicator of body image shame of students (P < .05). Furthermore, students' attitude towards nutrition had a significant and positive effect on the indicator of body image shame of students (P < .001). The findings underscore the need for interventions that address the negative effects of social media on young women's perceptions of their bodies and their relationship with food. By promoting media literacy, body positivity, and healthy nutritional attitudes, it is possible to mitigate the harmful effects of social media and support the well-being of young women.</p>","PeriodicalId":18549,"journal":{"name":"Medicine","volume":"104 4","pages":"e41383"},"PeriodicalIF":1.3,"publicationDate":"2025-01-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11771712/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143033400","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Gluteus medius contracture: A case report and review of the literature.","authors":"Yang Ma, Jiahao Gao, Fuwen Zheng, Jinshuo Tang, Chenyu Wang, Fengshuo Guo, Tong Liu, Jianlin Zuo","doi":"10.1097/MD.0000000000041311","DOIUrl":"10.1097/MD.0000000000041311","url":null,"abstract":"<p><strong>Rationale: </strong>Bilateral gluteus medius contractures in adults are rare in clinical practice, with only a few cases reported. These contractures may result from repeated intramuscular injections during childhood. Understanding the clinical manifestations, diagnostic process, treatment, and outcomes can provide insights into effective management strategies.</p><p><strong>Patient concerns: </strong>A 28-year-old female presented with an abnormal walking posture characterized by an out-toeing gait. She reported long-standing difficulties in walking and sought medical attention to improve her mobility and quality of life.</p><p><strong>Diagnoses: </strong>The patient was diagnosed with bilateral gluteus medius contractures.</p><p><strong>Interventions: </strong>The patient underwent open surgical release of the contractures on both sides, followed by a structured rehabilitation program to restore muscle function and improve gait. Postoperative exercise guidance was provided to ensure optimal recovery.</p><p><strong>Outcomes: </strong>At the 1-year follow-up, the patient demonstrated significant improvement in gait, functional abilities, and overall quality of life. She expressed high satisfaction with the surgical and rehabilitative outcomes.</p><p><strong>Lessons: </strong>Once diagnosed with gluteus medius contracture, early surgical intervention is recommended. Through case reports and literature review, we have summarized the etiology, diagnostic methods, clinical characteristics, and existing treatment options for this condition.</p>","PeriodicalId":18549,"journal":{"name":"Medicine","volume":"104 4","pages":"e41311"},"PeriodicalIF":1.3,"publicationDate":"2025-01-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11771728/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143033474","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Circulating inflammatory cytokines and colorectal cancer: New insights from Mendelian randomization.","authors":"Qinglu Fan, Jing Wang, Miao Tian, Abdulla Sawut, Di Xiao, Zuohuizi Yi, Liao Chen","doi":"10.1097/MD.0000000000041331","DOIUrl":"10.1097/MD.0000000000041331","url":null,"abstract":"<p><p>Colorectal cancer (CRC) is one of the most common cancers worldwide and inflammation is believed to play an important role in CRC. In this study, we comprehensively analyzed the causal association between 91 circulating inflammatory cytokines and the risk of CRC using Mendelian randomization (MR). Based on genome-wide association study summary statistics, we examined the causal effects of 91 circulating inflammatory cytokines on CRC. A series of MR methods, including bidirectional MR, replication sample MR, and multivariable MR, were employed to provide more robust causal estimates. After the validation with 3 MR methods and a series of sensitivity analyses, 2 circulating inflammatory factors were found to be significantly associated with the risk of CRC at the genetic level. Specifically, genetically predicted circulating levels of glial cell line-derived neurotrophic factor (GDNF) (OR = 1.12; 95% CI: 1.05-1.19; P = 2.72 × 10-4) and tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) (OR = 0.93; 95% CI: 0.91-0.99; P = 1.00 × 10-2) exerted causal effects on CRC risk. In conclusion, this study suggests that increased circulating levels of GDNF and TRAIL are associated with a higher and lower risk of CRC, respectively. GDNF and TRAIL may be 2 potential therapeutic targets that deserve future investigation.</p>","PeriodicalId":18549,"journal":{"name":"Medicine","volume":"104 4","pages":"e41331"},"PeriodicalIF":1.3,"publicationDate":"2025-01-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11771603/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143033665","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"EBUS-guided Iodine-125 seed implantation in lymph node as a novel therapy for MCAO: A case report.","authors":"Huiwen Qian, Jianqiang Jin, Changguo Wang, Yuting Wang, Juxiang Ge, Jianan Huang, Cheng Ji","doi":"10.1097/MD.0000000000041198","DOIUrl":"10.1097/MD.0000000000041198","url":null,"abstract":"<p><strong>Rationale: </strong>We report here a case of using iodine-125 (125I) seed implantation via endobronchial ultrasound (EBUS) in the treatment of malignant central airway obstruction (MCAO) in a patient with lung adenocarcinoma.</p><p><strong>Patient concerns: </strong>The patient still experienced MCAO after conventional bronchoscopic interventional therapy.</p><p><strong>Diagnoses: </strong>The patient was diagnosed as lung adenocarcinoma stage IV (T4N2M1a).</p><p><strong>Interventions: </strong>She received implantation of radioactive 125I seeds in the lesion inside the right middle lobe bronchus and 12R lymph node via bronchoscopy and EBUS, in combination with chemotherapy and immunotherapy.</p><p><strong>Outcomes: </strong>The patient's MCAO has been effectively controlled.</p><p><strong>Lessons: </strong>The success of this case suggests that EBUS-guided 125I seed implantation to lymph nodes is a safe and effective therapeutic option for MCAO.</p>","PeriodicalId":18549,"journal":{"name":"Medicine","volume":"104 3","pages":"e41198"},"PeriodicalIF":1.3,"publicationDate":"2025-01-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11749508/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143008210","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Gut microbiota, immune cells, and chronic sinusitis: A Mendelian randomization analysis.","authors":"Junwei Huang, Xiao Zhu, Jingxin Yao, Weili Yang, Zhenhua Zhu","doi":"10.1097/MD.0000000000041093","DOIUrl":"10.1097/MD.0000000000041093","url":null,"abstract":"<p><p>Allergic rhinitis (AR) is a common allergic inflammatory disease that affects the upper respiratory tract. Although previous research suggests a potential association between gut microbiota alterations and AR, the causal relationship remains unclear. This study employs Mendelian randomization (MR) to reduce confounding factors and reverse causality. By using genetic variants as instrumental variables, the MR approach aims to provide more reliable causal evidence of the relationship between gut microbiota, immune-related antibodies, and AR. This study utilized large-scale genome-wide association study data from the FINRISK 2002 cohort and the UK Biobank to systematically investigate the causal relationships between gut microbiota, antibody immune responses, and AR through a 2-sample MR approach. We applied the inverse variance weighting method to assess the potential mediating role of antibody immune responses in the interaction between gut microbiota and AR. MR analysis identified 17 gut microbiomes significantly associated with chronic rhinosinusitis (CRS) risk. Specifically, increased abundances of the CAG-884 and UBA1407 species were linked to a higher CRS risk, while greater levels of Atopobiaceae and Bacteroides thetaiotaomicron were associated with a reduced risk. In addition, of the 29 immune cell types correlated with CRS, 12 were found to increase risk, while 17 reduced it. Notably, CAG-884 indirectly influenced CRS risk by affecting the proportion of TD double negative (CD4-CD8-) % T cells, with a mediating effect ratio of 36.4%. Our findings confirm a causal relationship between gut microbiota and immune cells in relation to CRS, underscoring the mediating role of immune cells in this interaction.</p>","PeriodicalId":18549,"journal":{"name":"Medicine","volume":"104 3","pages":"e41093"},"PeriodicalIF":1.3,"publicationDate":"2025-01-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11749507/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143007734","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Current trends in pain management: A bibliometric analysis for the 1980-to-2023 period.","authors":"Emre Demir, Güvenç Doğan, Murat Kiraz, Arzu Akdağli Ekici, Selçuk Kayir, Musa Ekici, Gülçin Aydoğdu, Gül Doğan, Tuba Kayir","doi":"10.1097/MD.0000000000041319","DOIUrl":"10.1097/MD.0000000000041319","url":null,"abstract":"<p><p>There is currently no bibliometric analysis available regarding pain management (PM). The aim of this study was to monitor the advancement of the PM research field, demonstrate global productivity, identify the most highly cited studies, delineate collaborations between research areas and countries, and uncover new research topics and intriguing trends. A total of 16,216 articles on the subject of PM published between 1980 and 2023 were downloaded from the Web of Science database and analyzed using various bibliometric analysis methods. Trend keyword analysis, thematic evolution analysis, conceptual structure analysis, factor analysis, citation and co-citation analyses, and international collaboration analyses were conducted. The top 3 most active countries were the United States of America (n = 4021), the United Kingdom (n = 791), and Canada (n = 602). The most prolific author was Christine Miaskowski (n = 47). The most researched topics from the past to the present were chronic pain, opioids, analgesia/analgesics, cancer pain, postoperative pain, low back pain, opioid, cancer, acute pain, and self-management. Factor analysis identified key topics such as analgesia and various types of pain in the central factor, with additional subfactors including low back pain and physiotherapy, nursing, and postoperative anxiety and depression. In recent years, starting in 2020, trending research topics have shifted towards e-health, telemedicine, virtual reality, digital health, mental health, peripheral nerve blocks, erector spinae plane blocks, quadratus lumborum blocks, opioid use disorder, buprenorphine, musculoskeletal pain, COVID-19, cervicalgia, and interprofessional collaboration. In addition to Western countries with major economies in the field of PM (USA, Canada, Australia, and European countries), we identified China, India, and Turkey as research leaders. Our bibliometric analysis of 10,566 articles on PM reveals a significant growth in research, with recent trends focusing on e-health, telemedicine, virtual reality, and peripheral nerve blocks. These emerging technologies and personalized treatment approaches are shaping the future of PM.</p>","PeriodicalId":18549,"journal":{"name":"Medicine","volume":"104 3","pages":"e41319"},"PeriodicalIF":1.3,"publicationDate":"2025-01-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11749605/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143008191","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Osteosarcoma biomarker analysis and drug targeting prediction based on pyroptosis-related genes.","authors":"Yuxiang Zhuang, Xiaofeng Li","doi":"10.1097/MD.0000000000040240","DOIUrl":"10.1097/MD.0000000000040240","url":null,"abstract":"<p><p>Osteosarcoma is a malignant bone tumor originating from mesenchymal tissue. Recent studies have found that the tumor inflammatory microenvironment plays an important role in promoting the malignant characteristics and metastatic potential of malignant tumors. Pyroptosis, an inflammatory programmed cell death, elicits immune responses that exhibit anti-tumor effects through released factors and contents. Therefore, improving anti-tumor immunity by targeting osteosarcoma-related pyroptosis genes and pathways may be of great significance in delaying early metastasis of osteosarcoma and improving patient survival rate. The study aimed to identify pyroptosis-related genes and biomarkers in osteosarcoma, predicting therapeutic drugs targeting these genes. Gene expression profiles of osteosarcoma were retrieved from Gene Expression Omnibus and cross-referenced with GeneCards and Comparative Toxicogenomics Database to identify differentially expressed pyroptosis-related genes. We conducted enrichment analysis on intersecting genes to identify their biological processes and signaling pathways and assessed immune cell composition in the tumor microenvironment through immune infiltration analysis. In addition, we further utilized Cytoscape software to screen out the top 10 genes with Degree values among the intersected genes as hub genes and performed GSEA analysis and drug prediction based on the hub genes. A total of 22 differentially expressed pyroptosis-related genes were identified in osteosarcoma, with 10 of them (TP53, CYCS, IL-1A, IL-1B, IL-18, CASP-3, CASP-8, IL-6, TNF, CASP-1) pinpointed as hub genes. Enrichment analysis found that the 22 intersection genes are mainly associated with pyroptosis, apoptosis, immune regulation, and related biological processes. The results of data validation targeting hub genes suggest that IL-18, CASP-1, and CASP-8 may be key genes involved in the regulation of pyroptosis in osteosarcoma. Immune infiltration analysis shows statistical differences in the distribution of immune cells like naive B cells, monocytes, M2 macrophages, and dendritic/mast cells, suggesting they play a role in the osteosarcoma tumor microenvironment. Hub gene drug targets suggest Triethyl phosphate, Plinabulin, and Siltuximab as potential osteosarcoma treatments. Our findings suggest potential mechanisms of action for 22 pyroptosis-related genes in osteosarcoma and preliminarily predicted that the occurrence of osteosarcoma is closely related to pyroptosis, apoptosis, and immune regulation. Predicted Triethyl phosphate, Plinabulin, Siltuximab as potential osteosarcoma treatments.</p>","PeriodicalId":18549,"journal":{"name":"Medicine","volume":"104 3","pages":"e40240"},"PeriodicalIF":1.3,"publicationDate":"2025-01-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11749676/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143008196","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}