Medicine最新文献

{"title":"Twenty years of research on exercise-induced fatigue: A bibliometric analysis of hotspots, bursts, and research trends.","authors":"Qiwen Xuan, Lele Huang, Wei Gu, Changquan Ling","doi":"10.1097/MD.0000000000041895","DOIUrl":"10.1097/MD.0000000000041895","url":null,"abstract":"<p><p>Data from the Web of Science Core Collection (2004-2023) on \"exercise-induced fatigue\" were analyzed using bibliometric tools to explore research trends across countries, institutions, authors, journals, and keywords. The analysis was limited to \"Article\" and \"Review\" literature types. Among 4531 publications, the United States contributed the most articles (1005), followed by England (559) and China (516). The most influential institution was Universidade de São Paulo, while the most productive was Institut National de la Santé et de la Recherche Médicale with 103 papers. The European Journal of Applied Physiology ranked as the top journal with 233 articles. Millet Guillaume Y. emerged as the most prolific author, and Amann Markus was the most cited. Recent keyword trends showed a surge in terms like \"physical activity\" and \"aerobic exercise,\" while \"fatigue\" and \"exercise\" remained dominant. Notable findings were observed in oncology, engineering, and multidisciplinary studies, indicating potential research trends. Oxidative stress was identified as the most commonly mentioned mechanism in exercise-induced fatigue studies. This bibliometric analysis highlights current research trends and gaps, suggesting that future studies should focus on understanding the mechanisms of exercise-induced fatigue, developing objective measurement criteria, and exploring strategies for its alleviation.</p>","PeriodicalId":18549,"journal":{"name":"Medicine","volume":"104 12","pages":"e41895"},"PeriodicalIF":1.3,"publicationDate":"2025-03-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11936639/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143700970","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Current developments in 3D printing technology for orthopedic trauma: A review.","authors":"Kun Ling, Wenzhu Wang, Jie Liu","doi":"10.1097/MD.0000000000041946","DOIUrl":"10.1097/MD.0000000000041946","url":null,"abstract":"<p><p>Three-dimensional (3D) printing technology has emerged as a revolutionary tool in orthopedic trauma surgery, offering unprecedented opportunities for personalized patient care. This comprehensive review explores the current developments and applications of 3D printing in orthopedic trauma, highlighting its potential to address complex surgical challenges. We provide an in-depth analysis of various 3D printing technologies applicable to orthopedic surgery, including vat photopolymerization, material extrusion, powder bed fusion, and sheet lamination. The review examines the use of 3D printing in preoperative planning, surgical simulation, and the creation of patient-specific implants and surgical guides. We discuss applications across different anatomical regions, including upper limb, lower limb, and pelvic and spinal trauma. Evidence from recent studies demonstrates that 3D printing-assisted surgeries can lead to reduced operative times, decreased blood loss, improved fracture reduction quality, and potentially better clinical outcomes. This review synthesizes the latest research and clinical experiences, providing insights into the current state of 3D printing in orthopedic trauma and its future perspectives. As the technology continues to evolve, 3D printing holds promise for increasingly personalized and effective treatments in orthopedic trauma care, potentially transforming surgical practices and improving patient outcomes.</p>","PeriodicalId":18549,"journal":{"name":"Medicine","volume":"104 12","pages":"e41946"},"PeriodicalIF":1.3,"publicationDate":"2025-03-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11936578/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143700603","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Paclitaxel-coated balloon versus paclitaxel-eluting stent for femoropopliteal arterial disease: A meta-analysis.","authors":"Tingni Tang, Jie Fang, Yongbao Zhang","doi":"10.1097/MD.0000000000041949","DOIUrl":"10.1097/MD.0000000000041949","url":null,"abstract":"<p><strong>Background: </strong>Paclitaxel-coated balloon (PCB) and paclitaxel-eluting stent (PES) are widely used in femoropopliteal arterial disease (FPAD), while the comparison of their clinical benefit is inconclusive. This meta-analysis aimed to compare the efficacy between PCB and PES for FPAD.</p><p><strong>Methods: </strong>Three internet databases were searched for eligible randomized controlled trials (RCTs). Random-effects model was used for pooled clinical outcomes grouped by PCB or PES, following with an indirect comparison. Subgroup analysis was planned according to age, gender, history of smoking, hypertension, and diabetes.</p><p><strong>Results: </strong>Twenty-five RCTs encompassing 2806 patients were included. There were no significant differences between PCB and PES concerning the incidence of primary patency rate (risk of restenosis [RR]: 0.925; 95% CI: 0.815-1.049; P = .222), target lesion revascularization (TLR) (RR: 1.248; 95% CI: 0.798-1.952; P = .332), death (RR: 1.130; 95% CI: 0.436-2.930; P = .801), restenosis (RR: 1.012; 95% CI: 0.647-1.581; P = .959), amputation (RR: 1.000; 95% CI: 0.314-3.181; P = 1.000), and thrombosis (RR: 0.240; 95% CI: 0.049-1.180; P = .079). Subgroup analysis showed a lower primary patency rate in patients ≥ 70-year-old (RR: 0.703; 95% CI: 0.510-0.968; P = .031) and an increased risk of TLR when diabetes proportion was ≥ 40.0% (RR: 1.755; 95% CI: 1.013-3.042; P = .045) with PCB. Moreover, PCB might increase mortality in smokers (RR: 1.957; 95% CI: 1.000-3.828; P = .050).</p><p><strong>Conclusions: </strong>Regarding safety, no significant differences was found between PCB and PES. Further large-scale RCTs should be conducted based on the direct comparison results.</p>","PeriodicalId":18549,"journal":{"name":"Medicine","volume":"104 12","pages":"e41949"},"PeriodicalIF":1.3,"publicationDate":"2025-03-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11936668/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143700607","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Global research trends and hotspots on imaging of bladder cancer: A bibliometric and visual analysis from 1981 to 2023.","authors":"Zijian Gong, Zhixuan Liu, Jianghua Zhu, Zhen Zhao, Jia Qiu, Hongxin Ying, Yun Peng, Lianggen Gong, Yinquan Ye","doi":"10.1097/MD.0000000000041907","DOIUrl":"10.1097/MD.0000000000041907","url":null,"abstract":"<p><p>There was currently no bibliometric analysis available regarding to bladder cancer (BCa) imaging. The aim of this study was to conduct a comprehensive bibliometric analysis of relevant literature on the imaging of BCa and elucidate global research hotspots and further trends in this field. All relevant literature on the imaging of BCa published between 1981 and 2023 were retrieved from the Web of Science Core Collection. VOSviewer, Bibliometrix, and Citespace were utilized for bibliometric analysis of publications, countries, authors, institutions, journals, references, and keywords. A total of 4462 articles were retrieved. The research in this field has been increasing consistently since 1981. The United States of America was the most productive country and most productive institutions were from it. Shariat SF was the most productive author with 36 articles and the author with the highest co-citations was Herr HW (472). Journal of Urology was the most productive journal and Frontiers in Oncology, Abdominal Radiology and Cancers exhibited heightened activity in recent years. A study by Siegel RL, published in CA-A Cancer Journal for Clinicians in 2019, had the highest number of co-citations. Further analysis of the keyword analysis and timeline view revealed that \"radiomics,\" \"deep learning,\" \"multiparametric MRI,\" \"VI-RADS,\" \"muscle-invasive bladder cancer,\" \"immunotherapy,\" and \"long term outcome\" were the most recent hotspots. In totally, in the period of 1981 to 2023 year, the USA occupies a critical position in the field of BCa imaging. It is anticipated that MRI-based imaging-reporting and data system and deep learning will be the research hotspots in the future.</p>","PeriodicalId":18549,"journal":{"name":"Medicine","volume":"104 12","pages":"e41907"},"PeriodicalIF":1.3,"publicationDate":"2025-03-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11936662/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143700885","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Subjective smell and taste dysfunctions and prognosis in patients with COVID-19 admitted to a major public hospital in Southern Brazil: A retrospective cohort study (NUTRICOVID19).","authors":"Caio Wolff Ramos Baumstein, Vivian Cristine Luft, Caroline Marques de Lima Cunha, Zilda Elizabeth de Albuquerque Santos, Valesca Dall'Alba, Anderson Garcez, Raquel Canuto, Maria Teresa Anselmo Olinto","doi":"10.1097/MD.0000000000041866","DOIUrl":"10.1097/MD.0000000000041866","url":null,"abstract":"<p><p>The literature notes that coronavirus disease 2019 (COVID-19) patients with olfactory disturbances tend to have lower disease severity and that olfactory disturbances may act as a protective factor against mortality. So, this study aimed to explore the association of smell and/or taste disturbance with disease severity and all-cause mortality among patients who were hospitalized with COVID-19. A retrospective cohort study (Nutrition and COVID-19 Study [NUTRICOVID19]) was conducted with 1331 patients (men and women, age ≥ 18 years) hospitalized with COVID-19 between June and December 2020. Poisson and Cox regressions were used to investigate the unadjusted and adjusted associations between smell and/or taste disturbance and the following prognostic indicators: length of stay (LOS), intensive care unit admission, need for invasive mechanical ventilation (IMV), and mortality. Patients with altered smell and/or taste had a shorter LOS (9 vs 11 days), were less likely to require IMV (22% vs 35.1%), and experienced lower mortality (17.1% vs 29.2%) compared to those without such symptoms. After multivariable adjustment, patients with smell and/or taste disturbances were 33% less likely to need IMV compared to those without such symptoms (RR = 0.67; 95% CI = 0.50-0.88), but the relationship between these symptoms and mortality lost statistical significance. In this population of patients with COVID-19, the presence of smell and/or taste disturbances was associated to lower rates of IMV.</p>","PeriodicalId":18549,"journal":{"name":"Medicine","volume":"104 12","pages":"e41866"},"PeriodicalIF":1.3,"publicationDate":"2025-03-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11936614/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143700942","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Trends and disparities in the prevalence of diagnosed arthritis among United States adults from 2019 to 2022.","authors":"Hafsah Alim Ur Rahman, Muhammad Ahmed Ali Fahim, Afia Salman, Syed Hassan Ahmed, Sajeel Ahmed, Raheel Ahmed, Zohaib Yousaf","doi":"10.1097/MD.0000000000041892","DOIUrl":"10.1097/MD.0000000000041892","url":null,"abstract":"<p><p>Arthritis is a predominant cause of disability in the United States, imposing substantial economic burdens and public health challenges. This study aimed to analyze the trends and disparities in the prevalence of arthritis among US adults from 2019 to 2022. The National Health Interview Survey (NHIS) database of the Center for Disease Control and Prevention was analyzed, employing Joinpoint regression analysis for determining annual percentage changes (APCs) and prevalence percentages with 95% confidence intervals (CI). The prevalence of diagnosed arthritis among US adults remained relatively stable and slightly increased from 21.4% (95% CI: 20.9, 22.0) in 2019 to 21.6% (95% CI: 21.0, 22.2) in 2022 (APC: 0.4698; 95% CI: -1.0841, 2.0577). Females had a higher prevalence, which also increased from 24.3% to 25.0% (APC: 1.0218; 95% CI: -0.4408, 2.5223) with male prevalence ranging from 18.3% to 18.0% (APC: -0.3254; 95% CI: -2.6590, 2.0817). Age-related differences were particularly evident, with rates peaking in individuals aged ≥ 75 years at 53.9% in 2022. Racial disparities were observed, with White adults having a higher prevalence each year (23.8% in 2022). Geographic factors influenced prevalence, with higher rates noted in areas outside metropolitan areas and in the Midwest. Analysis of the NHIS database indicated a slight rise in arthritis prevalence overall, accompanied by notable demographic disparities. These results emphasize the necessity for tailored public health interventions and efficient disease management approaches tailored to specific populations.</p>","PeriodicalId":18549,"journal":{"name":"Medicine","volume":"104 12","pages":"e41892"},"PeriodicalIF":1.3,"publicationDate":"2025-03-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11936667/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143700969","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Efficacy of electroacupuncture on clinical signs and immunological factors in herpes zoster: The first systematic review, meta-analysis, and trial sequential analysis of randomized clinical trials.","authors":"Qiaoli Zhou, Mao Jing, Haitao Ren, Gaokai Li, Zongjiao Wang","doi":"10.1097/MD.0000000000041458","DOIUrl":"10.1097/MD.0000000000041458","url":null,"abstract":"<p><strong>Background: </strong>Electroacupuncture (EA) is utilized to address various health conditions. Herein, we designed a systematic review and meta-analysis to evaluate the efficacy of EA on clinical and immunological factors in herpes zoster (HZ) based on randomized clinical trials.</p><p><strong>Methods: </strong>Four international databases and 3 Chinese databases were searched until January 2024. We used RevMan 5.3 for meta-analysis and presented the data as standardized mean difference (SMD) or odds ratio (OR) and 95% confidence interval.</p><p><strong>Results: </strong>A total of 1361 records were identified in the databases and at last, 19 articles were entered into the meta-analysis. The result shows a negative pooled SMD of -2.55 (P < .00001) for the VAS score. The pooled SMD for cessation of pustules time in the case group compared to the control group was -0.69 (P = .0008), for pain relief time was -1.36 (P = .002), for the time to scab was -0.47 (P = .009), and for time to remove scab was -1.01 (P = .0003). The pooled OR for the incidence of postherpetic neuralgia was 0.11 (P < .00001), and the total effective rate was 4.25 (P < .00001). The pooled SMD for the cluster of differentiation (CD)3 count was 2.59 (P = .07), for the CD4 count was 2.81 (P = .04), for the CD8 count was -0.75 (P = .50), and for theCD4/CD8 ratio was 1.12 (P = .15).</p><p><strong>Conclusions: </strong>The results indicate that the EA treatment had several significant benefits compared to Western medicine (WM) in HZ patients in terms of clinical and immunological factors. But, the combination of treatments of EA with WM had better effects compared to EA treatment alone.</p>","PeriodicalId":18549,"journal":{"name":"Medicine","volume":"104 12","pages":"e41458"},"PeriodicalIF":1.3,"publicationDate":"2025-03-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11936656/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143700862","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Integrating network pharmacology and molecular docking to explore the pharmacological mechanism of tanshinone IIA in improving chronic obstructive pulmonary disease.","authors":"Huaiquan Liu, Shili Yang, Bo Chen, Shuoshuo Shao, Xinyan Zhang","doi":"10.1097/MD.0000000000041638","DOIUrl":"10.1097/MD.0000000000041638","url":null,"abstract":"<p><p>This study explores the mechanism of action of tanshinone IIA in the treatment of chronic obstructive pulmonary disease (COPD) using network pharmacology and molecular docking. The targets of tanshinone IIA were searched by Swiss Target Prediction Database, PharmMapper Database, SuperPred Database, and TargetNet Database. The targets of COPD were obtained by Genecards Database, OMIM Database, and Therapeutic Target Database, then the intersection targets were selected as the targets of tanshinone IIA in the treatment of COPD. The intersecting targets were imported into the STRING database to obtain the PPI network and the top10 relevant targets, and GO enrichment and KEGG signaling pathway analysis were performed by R language. Core targets were obtained by taking the intersection of Top5 GO and KEGG corresponding targets with Top10 targets in PPI. Then tanshinone IIA was molecularly docked to the screened core target protein receptors by AutoDock Vina software. Tanshinone IIA included 442 potential targets and 979 COPD-associated targets, and 104 intersecting targets were obtained by taking the intersection of the two. The PPI network showed that ALB, EGFR, CASP3, MMP9, PTGS2, NFKB1, ESR1, SRC, PPARG, and HSP90AA1 were the top 10 relevant targets. GO enrichment analyses showed that the main components involved were the response to response to lipopolysaccharide, response to molecule of bacterial origin, positive regulation of cytokine production, positive regulation of MAPK cascade, and positive regulation of kinase activity. KEGG signaling pathway analysis revealed major involvement in prostate cancer, AGE-RAGE signaling pathway in diabetic complications, Hepatitis B, PI3K-Akt signaling pathway, relaxin signaling pathway. EGFR, CASP3, MMP9, NFKB1, SRC, and HSP90AA1 were the 6 core targets. Molecular docking showed that the binding energies of tanshinone IIA and the core target were all less than ≤-5.0 kcal/mol, demonstrating good affinity. The treatment of COPD with tanshinone IIA involves multiple signaling pathways and biological processes, and its binding to the key targets of EGFR, CASP3, MMP9, NFKB1, SRC, and HSP90AA1 may be one of the important mechanisms of its action, which provides new theoretical ideas for the subsequent treatment of COPD with tanshinone IIA.</p>","PeriodicalId":18549,"journal":{"name":"Medicine","volume":"104 12","pages":"e41638"},"PeriodicalIF":1.3,"publicationDate":"2025-03-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11936567/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143700912","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"LncRNA MALAT1's role in the development of retinopathy: A review.","authors":"Gukun Yang, Xionggao Huang","doi":"10.1097/MD.0000000000041954","DOIUrl":"10.1097/MD.0000000000041954","url":null,"abstract":"<p><p>Long noncoding RNA (lncRNA) metastasis-associated lung adenocarcinoma transcript 1 (MALAT1) and retinopathy are 2 distinct yet interconnected areas of research in the field of ocular studies. MALAT1, with its diverse biological functions, has been extensively studied and demonstrated to play a role in various diseases, including ocular pathologies. Its involvement in alternative splicing regulation, transcriptional control, and the competing endogenous RNA (ceRNA) network suggests its potential implication in retinopathy. Retinopathy refers to a group of disorders that affect the retina, leading to vision impairment and, in severe cases, even blindness. These conditions include diabetic retinopathy, retinoblastoma, proliferative vitreoretinopathy, retinopathy of prematurity, and retinal neurodegeneration. The understanding of the molecular mechanisms underlying the development and progression of retinopathy, along with the potential involvement of MALAT1, can provide valuable insights for the diagnosis and treatment of this condition. Retinopathy, characterized by various manifestations and underlying mechanisms, presents a significant challenge in the field of ophthalmology. As a complex disease, its pathogenesis involves multifactorial factors, including angiogenic dysregulation, inflammatory responses, oxidative stress, and cellular signaling abnormalities. The emerging role of long noncoding RNA MALAT1 in retinopathy has attracted considerable attention. MALAT1 has been found to participate in multiple cellular processes, including alternative splicing regulation and transcriptional control. Additionally, the competing endogenous RNA (ceRNA) network involving MALAT1 indicates its potential relevance as a regulator in retinopathy. Further investigations into the specific mechanisms underlying MALAT1's involvement in retinopathy pathogenesis may provide valuable insights into the development of diagnostic and therapeutic approaches for managing retinal disorders.</p>","PeriodicalId":18549,"journal":{"name":"Medicine","volume":"104 12","pages":"e41954"},"PeriodicalIF":1.3,"publicationDate":"2025-03-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11936551/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143700913","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The efficacy of microwave therapy combined with focused ultrasound or white spot ointment combined with infrared light in the treatment of female vulvar sclerotic lichen.","authors":"Dan Lu, Huan Wang, Mengke Wang, Xiaojiao Pei, Xixia Du, Xinrong Zhang","doi":"10.1097/MD.0000000000041716","DOIUrl":"10.1097/MD.0000000000041716","url":null,"abstract":"<p><p>This study aims to investigate the effectiveness of microwave therapy combined with focused ultrasound or white spot ointment combined with infrared light for treating vulvar sclerosing lichen in females. A retrospective study was conducted on 126 patients with vulvar lichen sclerosus admitted to our hospital between August 2020 and December 2022. The patients were divided into 3 groups: microwave treatment, focused ultrasound, and white spot paste combined with infrared light, each group consisting of 42 cases. The microwave treatment group underwent microwave coagulation using a multifunctional microwave treatment machine, the focused ultrasound group received focused ultrasound treatment, and the white spot paste combined with infrared light group received traditional Chinese medicine white spot paste combined with infrared light irradiation. All groups received additional basic treatment. The study compared the serum levels of interleukin-2 (IL-2), tumor necrosis factor-alpha (TNF-α), C-reactive protein (CRP), human epidermal growth factor (EGF) levels, visual analog pain scale scores, and skin quality of life index (DLQI) scores before and after treatment in the 3 groups. Before treatment, there was no statistically significant difference in CRP and EGF levels among the 3 groups receiving IL-2 and TNF-α (all P > .05). After treatment, the levels of IL-2 and TNF-α did not show significant differences across the 3 groups. However, the levels of CRP and EGF were notably reduced, particularly in the group treated with white spot cream combined with infrared light, which exhibited lower levels compared to the other 2 groups with statistical significance (both P < .05). Similarly, prior to treatment, there were no statistically significant differences in symptomatology, daily activities, and interpersonal relationship scores among the 3 groups (P < .05). Post-treatment, scores for all dimensions significantly decreased in all groups, with the group receiving white spot cream combined with infrared light showing lower scores across all dimensions compared to the other 2 groups, with statistical significance (P < .05). The combination of vitiligo cream and infrared light has a significant effect on the treatment of sclerotic lichen of the external genitalia in gynecology. It can reduce the levels of inflammatory factors in the patient's body, improve itching, and improve quality of life.</p>","PeriodicalId":18549,"journal":{"name":"Medicine","volume":"104 12","pages":"e41716"},"PeriodicalIF":1.3,"publicationDate":"2025-03-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11936540/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143700964","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}