Medicine最新文献

{"title":"Preoperative inflammatory status as a positive prognostic factor for triple-negative breast cancer patients receiving neoadjuvant therapy.","authors":"Tengfei Zhang, Xu Lu","doi":"10.1097/MD.0000000000042208","DOIUrl":"10.1097/MD.0000000000042208","url":null,"abstract":"<p><p>The aim of this study was to investigate the ability of preoperative systemic inflammatory status to predict the clinical outcomes of triple-negative breast cancer (TNBC) patients who undergo neoadjuvant therapy. This retrospective study included a total of 273 TNBC patients who underwent neoadjuvant therapy at Harbin Medical University Cancer Hospital from January 2017 to December 2021. All patients underwent preoperative blood tests, and the following inflammatory and immune indices were calculated for each patient: neutrophil-to-lymphocyte ratio, platelet-to-lymphocyte ratio, monocyte-to-lymphocyte ratio, systemic immune-inflammatory index, systemic inflammatory response index (SIRI), and advanced lung cancer inflammation index. The observed outcomes included progression-free survival (PFS) and overall survival (OS). Survival analysis was performed using Kaplan-Meier survival curves, Cox survival analysis, decision curve analysis, propensity score matching analysis, and a nomogram to comprehensively investigate the impact of inflammatory status on patient survival. This study included a total of 273 TNBC patients with a mean age of 50.25 (9.87) years. Among them, 131 (48.0%) had tumor-node-metastasis stage II disease, and 142 (52.0%) had tumor-node-metastasis stage III disease. A total of 91 patients achieved a pathological complete response following neoadjuvant therapy. Survival analysis revealed that all preoperative inflammatory indices were associated with PFS and OS. Additionally, receiver operating characteristic curves revealed a greater prognostic value for the SIRI. Following the elimination of collinearity through least absolute shrinkage and selection operator regression analysis, the SIRI was identified as an independent prognostic factor in this study. Risk factor scores and nomograms that included the SIRI also demonstrated high accuracy. Even after propensity score matching analysis with a matching tolerance of 0.02 for the SIRI, the SIRI continued to exhibit predictive ability for PFS and OS, indicating its considerable potential in this study. Preoperative inflammatory status was associated with the prognosis of TNBC patients receiving neoadjuvant therapy. Furthermore, the SIRI exhibited the highest prognostic value in this study and could identify postoperative high-risk patients.</p>","PeriodicalId":18549,"journal":{"name":"Medicine","volume":"104 28","pages":"e42208"},"PeriodicalIF":1.3,"publicationDate":"2025-07-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12263038/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144637484","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Analysis of combined shockwave therapy and aquatic exercise for chronic nonspecific low back pain.","authors":"Bao Zhang, Mengjun Liu, Zhongxi Bai, Luoyi Shi, Junfeng Zhang, Yuling Gao","doi":"10.1097/MD.0000000000043176","DOIUrl":"10.1097/MD.0000000000043176","url":null,"abstract":"<p><p>This study evaluates the clinical efficacy of combined shockwave therapy and aquatic exercise therapy in patients with chronic nonspecific low back pain (CNLBP) and compares it with conventional treatments to provide evidence for clinical practice. A retrospective cohort study was conducted with 108 CNLBP patients who visited our hospital from April 2022 to April 2023. Patients were divided into a combined therapy group (41 cases) and a conventional therapy group (67 cases). Propensity score matching adjusted for baseline characteristics. The combined therapy group received both shockwave therapy and aquatic exercise, while the conventional therapy group received traditional physical therapy. Patient outcomes were assessed using the visual analog scale, Oswestry disability index, and short form 36-item health survey quality of life questionnaire. After matching, there were no significant differences in baseline characteristics between the 2 groups (P > .05). The combined therapy group showed better results in several clinical measures. Visual analog scale scores decreased from 6.9 ± 1.3 to 3.2 ± 1.1 in the combined therapy group, compared to 7.1 ± 1.4 to 4.5 ± 1.3 in the conventional group (P = .021). The combined therapy group's Oswestry disability index (ODI) score decreased from 38.5 ± 6.8 to 20.3 ± 5.2, better than the conventional group, which decreased from 39.1 ± 6.9 to 25.1 ± 6.3 (P = .045). The combined therapy group's Berg balance scale improved from 42.5 ± 5.2 to 51.2 ± 3.4, while the conventional group improved from 43.0 ± 5.5 to 47.8 ± 4.6 (P = .029). Significant improvements were also observed in anxiety (hospital anxiety and depression scale) and sleep quality (Pittsburgh sleep quality index). In quality of life, the short form 36-item health survey score in the combined therapy group increased from 45.3 ± 8.2 to 75.1 ± 7.6, significantly better than the conventional group's increase from 43.7 ± 7.9 to 68.2 ± 8.4 (P = .038). Combined shockwave therapy and aquatic exercise therapy significantly improve pain, function, posture control, psychological health, and quality of life in CNLBP patients, outperforming conventional physical therapy. This noninvasive and effective rehabilitation method is recommended for wider clinical use to enhance recovery and quality of life.</p>","PeriodicalId":18549,"journal":{"name":"Medicine","volume":"104 28","pages":"e43176"},"PeriodicalIF":1.3,"publicationDate":"2025-07-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12262937/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144637511","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Bacteria into bloodstream caused by oral probiotics based on whole genome sequencing: A case report.","authors":"Tianqi Qi, Yingshi Wang, Yanhui Liu, Wenqiang Li, Shanshan Wu","doi":"10.1097/MD.0000000000043337","DOIUrl":"10.1097/MD.0000000000043337","url":null,"abstract":"<p><strong>Rationale: </strong>Bacillus licheniformis and Lactiplantibacillus plantarum are facultative anaerobes and gram-positive bacteria. They are commonly included in probiotic preparations and are administered orally in clinical practice to promote a balanced gut microbiota.</p><p><strong>Patient concerns: </strong>An 85-year-old man with irritable bowel syndrome and reflux esophagitis underwent distal pancreatectomy and was administered oral probiotics. Blood culture was positive for B. licheniformis and L. plantarum. We conducted whole-genome sequencing for homology analysis and pathogenicity prediction of the strains isolated from the patient's blood culture and oral probiotics.</p><p><strong>Diagnosis: </strong>The initial diagnosis was bacterial entry into the bloodstream resulting from the consumption of B. licheniformis and L. plantarum probiotic preparations.</p><p><strong>Interventions: </strong>The patient was treated with discontinuation of oral probiotics and timely administration of antibiotics.</p><p><strong>Outcomes: </strong>Follow-up blood culture results after treatment were negative.</p><p><strong>Lessons: </strong>Probiotics are generally considered relatively safe but should be preceded by risk screening in vulnerable populations. Whole-genome sequencing revealed the potential risks of probiotic use through homology analysis and prediction of virulence factors and antibiotic resistance.</p>","PeriodicalId":18549,"journal":{"name":"Medicine","volume":"104 28","pages":"e43337"},"PeriodicalIF":1.3,"publicationDate":"2025-07-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12262941/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144637531","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Causal links and mediating effects of lipid metabolism, immune cells, and inflammatory proteins in endometriosis: Evidence from Mendelian randomization.","authors":"Pei Guo, Junhong Gan, Lin Xu, Weihong Li","doi":"10.1097/MD.0000000000043163","DOIUrl":"10.1097/MD.0000000000043163","url":null,"abstract":"<p><p>Endometriosis (EMS) is a complex gynecological disorder whose pathogenesis remains poorly understood, with lipid metabolism, immune regulation, and inflammation likely playing pivotal roles. This Mendelian randomization study investigates causal relationships between lipid metabolic levels, immune cell characteristics, inflammatory proteins, and EMS using multi-omics data from 179 lipid metabolites, 731 immune cell traits, and 91 inflammatory proteins, combined with EMS cases from the FinnGen database. Sensitivity analyses were conducted using inverse variance weighted, Mendelian randomization Egger regression, weighted median, and weighted mode methods to ensure robust findings. Our analysis identified significant associations between 21 lipid metabolites and EMS, with 9 metabolites showing protective effects and 12 promoting risk. Specifically, triacylglycerol (46:2) levels displayed a reverse causal relationship with EMS. Additionally, 32 immune cell traits and 6 inflammatory proteins were linked to EMS risk, with IL-17A, TNF-related apoptosis-inducing ligand, and C-C motif chemokine 4 emerging as key inflammatory proteins. Notably, IL-17A was positively correlated with EMS progression, while TNF-related apoptosis-inducing ligand and C-C motif chemokine 4 exhibited protective effects. Mediation analysis further uncovered pathways where lipid metabolites modulate immune responses and inflammatory proteins, influencing EMS development. These findings suggest that lipid metabolism, immune traits, and inflammatory proteins may contribute to EMS pathogenesis, offering initial insights into potential mechanisms. Further experimental validation is needed to corroborate these results.</p>","PeriodicalId":18549,"journal":{"name":"Medicine","volume":"104 28","pages":"e43163"},"PeriodicalIF":1.3,"publicationDate":"2025-07-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12263052/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144637537","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The impact of sarcopenia on adverse effects and survival in patients with metastatic hormone receptor-positive breast cancer treated with CDK4/6 inhibitors.","authors":"Vahit Can Cavdar, Mert Aric, Ibrahim Taskin Rakici, Ilkay Gulturk, Zekiye Busra Karaca, Cigdem Usul Afsar, Goncagul Akdag, Riza Umar Gursu, Ozgur Han, Basak Ballica","doi":"10.1097/MD.0000000000043374","DOIUrl":"10.1097/MD.0000000000043374","url":null,"abstract":"<p><p>Breast cancer is the most commonly diagnosed malignancy worldwide. In hormone receptor-positive, human epidermal growth factor receptor 2-negative metastatic breast cancer (mBC), cyclin-dependent kinase 4/6 inhibitors (CDK4/6i) are the standard treatment. Sarcopenia, characterized by progressive muscle loss, is increasingly recognized as a factor influencing cancer outcomes. This study evaluated the impact of preexisting sarcopenia on overall survival, progression-free survival, and treatment-related adverse effects in patients receiving CDK4/6i therapy. A retrospective analysis was conducted on hormone receptor-positive mBC patients treated with CDK4/6i at Istanbul Training and Research Hospital between 2020 and 2024. Patients were classified as sarcopenic or non-sarcopenic based on pretreatment computed tomography muscle mass measurements. Survival outcomes were assessed using Kaplan-Meier analysis, and treatment-related adverse effects, including dose reductions, acute kidney injury, liver function test abnormalities, and neutropenia, were compared between groups. Among 111 patients, 20 (18%) were identified as sarcopenic. Sarcopenia was associated with significantly lower overall survival and progression-free survival compared to non-sarcopenic patients (P = .000). However, no significant differences were observed between groups in treatment-related adverse effects, including the need for dose reduction, acute kidney injury, liver function abnormalities, and neutropenia (P > .05). Sarcopenia negatively impacts survival outcomes in hormone receptor-positive mBC patients receiving CDK4/6i therapy. Routine screening and targeted interventions, such as nutritional support and physical activity programs, may help improve patient resilience and treatment efficacy. Further research is needed to develop strategies to mitigate sarcopenia's impact on survival in this patient population.</p>","PeriodicalId":18549,"journal":{"name":"Medicine","volume":"104 28","pages":"e43374"},"PeriodicalIF":1.3,"publicationDate":"2025-07-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12262979/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144637547","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"COVID-19 vaccination status and the risk of developing lung diseases: A Mendelian randomization study.","authors":"Donghua Niu, Miao Song, Mengjie Chen, Xiuhua Wu, Yujian Zhang, Rongwei Zhou","doi":"10.1097/MD.0000000000043102","DOIUrl":"10.1097/MD.0000000000043102","url":null,"abstract":"<p><p>Recent studies have suggested an increased incidence of various lung diseases following COVID-19 vaccination. However, causal relationships have not been definitively established. We conducted a two-sample Mendelian randomization (MR) study using publicly available genome-wide association study data to investigate potential causal relationships between COVID-19 vaccination status as the exposure and 14 different lung diseases as outcomes. The analytical methods included random-effects inverse-variance weighting, MR Egger, and weighted median, with additional heterogeneity and sensitivity analyses. Seven instrumental variables for exposure were selected (P < 5 × 10-8). MR analyses revealed that COVID-19 vaccination status was not associated with an increased risk of developing overall lung cancer (P = .78), lung adenocarcinoma (P = .557), squamous cell lung cancer (P = .557), non-small cell lung cancer (P = .173), asthma (P = .905), chronic obstructive pulmonary disease, bronchiectasis (P = .669), forced vital capacity (FVC), forced expiratory volume in 1 second/FVC (P = .794), pneumonia (P = .282), idiopathic pulmonary fibrosis (P = .486), pulmonary embolism (P = .267), pneumothorax (P = .73), or sarcoidosis (P = .732). Evidence of heterogeneity was observed in the inverse-variance weighting model for overall lung cancer, chronic obstructive pulmonary disease, and FVC, whereas no indications of horizontal pleiotropy or significant heterogeneity were noted for other lung diseases. COVID-19 vaccination does not appear to increase the risk of developing various lung diseases. These findings support the safety of COVID-19 vaccines in terms of respiratory health, reinforcing their role in public health interventions and vaccination policies.</p>","PeriodicalId":18549,"journal":{"name":"Medicine","volume":"104 28","pages":"e43102"},"PeriodicalIF":1.3,"publicationDate":"2025-07-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12263066/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144637552","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Facial paint contamination: A new removal technique by using paraffin oil.","authors":"Xiao-Xue Tan, Dan-Dan Hou, Nan Xu, Jie-Feng Huang, Min Xu, Ya-Hong Zhu","doi":"10.1097/MD.0000000000043394","DOIUrl":"10.1097/MD.0000000000043394","url":null,"abstract":"<p><p>Facial paint contamination is a common issue, and traditional removal methods, such as turpentine, can be irritating, particularly in sensitive areas such as the eyes and mucous membranes. There is a pressing need for safer and more effective alternatives for paint removal from the facial skin. This retrospective study aimed to evaluate the effectiveness of paraffin oil in removing facial paint stains. A total of 6 patients with facial paint contamination were treated at the emergency center of The First Affiliated Hospital of Zhejiang Chinese Medical University between March 2021 and October 2023. Paraffin oil was applied to the contaminated areas using sterile cotton balls or gauze, and gentle rubbing was performed until the paint was removed. Patients with concomitant skin lacerations received appropriate treatment, while those with paint in sensitive areas (e.g., eyes, nose) were referred to relevant specialists. Paraffin oil proved to be an effective agent for paint removal, with no allergic reactions or complications observed. The average time required for paint removal ranged from 27.5 to 30 s/cm². The procedure was well-tolerated, and no adverse effects were noted. Using paraffin oil provided a safe, rapid, and nonirritating method for removing facial paint, with minimal sensitization risk.</p>","PeriodicalId":18549,"journal":{"name":"Medicine","volume":"104 28","pages":"e43394"},"PeriodicalIF":1.3,"publicationDate":"2025-07-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12262999/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144637564","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Lactobacillus paracasei-induced lung abscess in a splenectomized patient: A rare case report.","authors":"Zhimin Xiao, Yan Gu","doi":"10.1097/MD.0000000000043162","DOIUrl":"10.1097/MD.0000000000043162","url":null,"abstract":"<p><strong>Rationale: </strong>Lactobacillus paracasei (LP), a probiotic species, is rarely associated with lung abscesses. This case highlights its role as an opportunistic pathogen in immunocompromised patients.</p><p><strong>Patient concerns: </strong>A 65-year-old splenectomized man presented with persistent abdominal pain, fever, and respiratory symptoms. Imaging revealed a right lung abscess, mediastinal lymphadenopathy, and adrenal nodules. Next-generation sequencing (NGS) confirmed LP infection. Multidisciplinary management with tailored antibiotics (faropenem) led to clinical improvement.</p><p><strong>Diagnoses: </strong>Comprehensive examination, including imaging studies, revealed a right lung abscess complicated by mediastinal lymphadenopathy, bilateral pleural effusion, and adrenal nodules. Subsequent lung puncture biopsy and NGS testing confirmed LP infection and the presence of an accessory spleen.</p><p><strong>Interventions: </strong>In collaboration with a multi-disciplinary treatment, the patient's antibiotic treatment plan was adjusted based on the confirmed diagnosis of LP infection. Management included targeted antibiotic therapy (faropenem) tailored to the identified pathogen.</p><p><strong>Outcomes: </strong>The patient's condition gradually improved following the adjusted treatment plan, leading to a reduction in symptoms and successful discharge from the hospital, with favorable follow-up results.</p><p><strong>Lessons: </strong>This case highlights LP as an emerging opportunistic pathogen causing severe lung abscesses in splenectomized patients. Early diagnosis via NGS and targeted antibiotic therapy guided by multidisciplinary collaboration were pivotal in achieving clinical resolution. Our findings underscore the importance of pathogen-specific management in immunocompromised hosts.</p>","PeriodicalId":18549,"journal":{"name":"Medicine","volume":"104 28","pages":"e43162"},"PeriodicalIF":1.3,"publicationDate":"2025-07-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12263016/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144637572","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"NOACs versus warfarin in people with atrial fibrillation and thyroid dysfunction.","authors":"Lian Tan, Jie Feng, Biao Xiong, Guiqing Xiong, Xinting Zhu, Jie Jian, Yuan Song, Huang Zhou","doi":"10.1097/MD.0000000000043328","DOIUrl":"10.1097/MD.0000000000043328","url":null,"abstract":"<p><p>Anticoagulant therapy is an important measure to prevent stroke or other embolic events in patients with atrial fibrillation (AF). Warfarin, a classical anticoagulant, has a narrow therapeutic range and requires frequent testing and adjustment, making it inconvenient for patients. Additionally, thyroid dysfunction affects the coagulation-fibrinolysis imbalance, with hyperthyroidism increasing the risk of thrombosis and hypothyroidism increasing the risk of bleeding. The study aimed to evaluate the safety and effectiveness of non-vitamin K antagonist oral anticoagulants (NOACs) compared to warfarin in thyroid dysfunction patients. This retrospective study was conducted at 2 academic medical centers in southwestern China, including patients at least 18 years of age with abnormal thyroid function who were initiated on NOACs or warfarin for AF. The primary endpoint was the composite of clinical failure, including mortality, stroke incidence, and major bleeding events. We compared the baseline characteristics and the complex endpoint between NOACs group and warfarin group. A total of 137 patients, 86 receiving NOACs and 51 receiving warfarin were included in the final analysis. At the baseline, the prevalence of chronic heart failure was more common in those receiving warfarin (79.6% vs 55.3%, P = .005), who also had higher CHA2DS2-VASc scores (89.8% vs 74.12% in male ≥ 2 or female ≥ 3, P = .029). It is found that NOACs had a significantly higher estimated 3-year complex endpoint survival rate compared to warfarin. Stratified analyses show that patients with a body mass index < 24 kg/m2 being at a higher risk of experiencing endpoint events. NOACs appear to be superior to warfarin in long-term survival rate for patients with AF and thyroid dysfunction, especially in those with body mass index < 24 kg/m2.</p>","PeriodicalId":18549,"journal":{"name":"Medicine","volume":"104 28","pages":"e43328"},"PeriodicalIF":1.3,"publicationDate":"2025-07-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12262976/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144637579","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The relation between earthquake stress coping strategies and post-earthquake trauma level.","authors":"Zaliha Akkadin Candan, Ayşegül Aydin, Fatih Altan, Demet Unalan, Tülin Filik","doi":"10.1097/MD.0000000000043345","DOIUrl":"10.1097/MD.0000000000043345","url":null,"abstract":"<p><p>The study aims to determine the trauma level of individuals who have experienced and witnessed the earthquake disaster and to reveal the strategies they used to cope with the stress of the earthquake. This cross-sectional and descriptive research population includes adults residing in Türkiye (n = 760). The IBM SPSS software was used to analyze the data, while t test and ANOVA tests were conducted for between-group comparison. Correlation analysis was conducted to evaluate the correlation between the variables. The study revealed that women, single individuals, associate degree graduates, those with income below minimum wage, residents of earthquake-affected cities, people who lost relatives in the earthquake, lived in non-earthquake-resistant houses, had active fault lines in their city, and lacked earthquake education had higher post-earthquake trauma levels. A negative correlation was found between age and trauma, while a positive correlation emerged between age and coping strategies. Religious coping was positively linked to emotive limitation and cognitive structure, while positive reappraisal and seeking social support were negatively associated with behavioral, emotive, cognitive, and sleep problems. These findings suggest that psychosocial support and education cannot overlook individual and geographical differences.</p>","PeriodicalId":18549,"journal":{"name":"Medicine","volume":"104 28","pages":"e43345"},"PeriodicalIF":1.3,"publicationDate":"2025-07-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12263062/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144637601","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}