Medicine最新文献

{"title":"Perioperative Wernicke's encephalopathy associated with thiamine deficiency: Intraoperative EEG findings and anesthetic implications: a case report.","authors":"Yan Liu, Kejia Zhang, Tian Xie, Yue Wen, Bo Zhao, Yong Wang","doi":"10.1097/MD.0000000000048518","DOIUrl":"10.1097/MD.0000000000048518","url":null,"abstract":"<p><strong>Rationale: </strong>Wernicke encephalopathy (WE) results from thiamine deficiency and frequently affects nonalcoholic surgical patients with prolonged fasting and parenteral nutrition. Perioperative WE is often misdiagnosed due to nonspecific symptoms, and its intraoperative electroencephalographic and anesthetic features remain poorly understood.</p><p><strong>Patient concerns: </strong>A 68-year-old male underwent hepatic surgery for malignant obstructive jaundice. Postoperative biliary anastomotic leakage and aphagia led to long-term parenteral nutrition. The patient subsequently developed confusion, somnolence, nystagmus, visual loss, and peripapillary retinal hemorrhage. He also showed abnormal cerebral reactivity to anesthetics during secondary surgery.</p><p><strong>Diagnoses: </strong>Clinical diagnosis: nonalcoholic WE with thiamine-deficiency retinopathy. Infectious, septic encephalopathy and cerebral infarction were excluded.</p><p><strong>Interventions: </strong>Immediate high-dose intramuscular thiamine and magnesium supplementation were initiated. During secondary surgery, anesthesia was cautiously titrated with continuous electroencephalography and patient state index monitoring, with reduced anesthetic doses. Maintenance thiamine therapy was continued postoperatively.</p><p><strong>Outcomes: </strong>Neurological symptoms markedly improved within 3 days after thiamine treatment. Intraoperative electroencephalography revealed diffuse slowing and burst suppression under low anesthetic doses. The patient fully recovered without permanent neurological or ophthalmic sequelae and was discharged uneventfully.</p><p><strong>Lessons: </strong>Prolonged postoperative parenteral nutrition confers high WE risk in nonalcoholic surgical patients. Early empirical thiamine supplementation is essential. Thiamine deficiency increases neuronal sensitivity to anesthetics. Clinicians should enhance perioperative nutritional risk assessment and optimize anesthetic management to avoid severe cerebral complications.</p>","PeriodicalId":18549,"journal":{"name":"Medicine","volume":"105 18","pages":"e48518"},"PeriodicalIF":1.4,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13138486/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147817114","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparison of root resorption severity after fixed and invisible orthodontic treatment in patients with four first premolar extractions: A retrospective study.","authors":"Li Su, Qichao Kang, Xu Zhang, Dan Li, Chen Luo, Zhe Tang, Jingwen Wang, Norma Ab Rahman","doi":"10.1097/MD.0000000000048605","DOIUrl":"10.1097/MD.0000000000048605","url":null,"abstract":"<p><p>Root resorption is a common and unavoidable complication of orthodontic treatment, with limited research on its pattern in extraction cases using clear aligners. This study compared the severity of root resorption between fixed appliances and clear aligners in patients who underwent 4 first premolar extractions. A retrospective analysis was conducted on 28 patients with Angle Class I and II malocclusion treated with fixed appliances (n = 14) or clear aligners (n = 14) from 2019 to 2025. The mean treatment duration was 37.93 ± 13.65 months. Root resorption was assessed for both groups involving 488 teeth for right and left first molar and anterior teeth until canine for both arches excluding first and second premolar using the relative root-to-crown ratio on panoramic radiographs and tooth movement was measured using cephalometric superimposition. Chi-square and Mann-Whitney U tests were used to evaluate group differences. The proportion of teeth with no root resorption was significantly higher in the clear aligner group (52.67%, 236 teeth; χ2 = 11.253, P = .010) compared fixed appliance group (42.86%, 192 teeth). For upper anterior teeth, the fixed appliance group had a notably higher rate of moderate-to-severe resorption (40.91%) compared to the clear aligner group (17.14%; χ2 = 33.651, P < .001). For upper first molars and lower first molars, the clear aligner group also showed higher proportions of teeth without resorption (upper first molars: 28 vs 20 teeth, χ2 = 11.333, P = .010; lower first molars: 36 vs 16 teeth, χ2 = 15.692, P = .001). In terms of tooth movement, only the vertical (Y-axis) movement of lower anterior teeth differed significantly between groups: 0.8814 ± 1.01909 mm (fixed appliances, 95% CI: 0.06107-1.82393) versus 1.1314 ± 0.70874 mm (clear aligners, 95% CI: 0.47595-1.78690; P = .017), with no significant differences in other directions (all P > .05). Fixed appliances may increase the risk of moderate-to-severe root resorption in anterior teeth due to continuous heavy forces, while clear aligners reduce severe resorption but require caution during vertical movements.</p>","PeriodicalId":18549,"journal":{"name":"Medicine","volume":"105 18","pages":"e48605"},"PeriodicalIF":1.4,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13138394/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147817269","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Drug fever induced by Xingnaojing injection: A case report.","authors":"Weiqian Liu, Bo Gao, Shaowei Xie, Ye Yuan, Yu Yin","doi":"10.1097/MD.0000000000048482","DOIUrl":"10.1097/MD.0000000000048482","url":null,"abstract":"<p><strong>Rationale: </strong>The application of Xingnaojing injection is widespread; however, drug-induced fever associated with this medication is challenging to diagnose. Previous literature rarely reports cases of drug-induced fever resulting from the use of Xingnaojing injection.</p><p><strong>Patient concerns: </strong>A 46-year-old male patient, who underwent surgery for cerebral hemorrhage, presented with fever. The condition is considered to be drug fever induced by the administration of Xingnaojing.</p><p><strong>Diagnoses: </strong>Considering the potential for drug fever associated with the administration of Xingnaojing injection.</p><p><strong>Interventions: </strong>Discontinue the use of Xingnaojing injection.</p><p><strong>Outcomes: </strong>The patient has shown improvement and is being discharged.</p><p><strong>Lessons: </strong>Clinical practitioners should enhance the prevention and management of adverse drug reactions to reduce both patient hospitalization duration and economic costs, thereby ensuring the safety of medication use for patients.</p>","PeriodicalId":18549,"journal":{"name":"Medicine","volume":"105 18","pages":"e48482"},"PeriodicalIF":1.4,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13138454/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147817277","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Impact of competitive anxiety on mood, sleep, and physical activity levels in young Tunisian karate athletes: A multidimensional prospective observational study.","authors":"Ahlem Belgacem, Atef Salem, Mevlüt Yildiz, Halil İbrahim Ceylan, Said Ben Hassen, Yassine Negra, Raul Ioan Muntean, Mohamed Jarraya","doi":"10.1097/MD.0000000000048435","DOIUrl":"10.1097/MD.0000000000048435","url":null,"abstract":"<p><p>This study examined the impact of competition-related anxiety on psychological and behavioral parameters of Tunisian karate athletes. A total of 176 young Tunisian karate athletes (aged 16-25 years) with at least 1 year of training and competitive experience voluntarily participated in this study. Validated instruments were administered 1 week before and on the day of the competition, including the State-Trait Anxiety Inventory, the Pittsburgh Sleep Quality Index, the Brunel Mood Scale, and the International Physical Activity Questionnaire. Paired Wilcoxon signed-rank tests were used to compare changes over time, and multiple linear regression models were used to identify predictors of state and trait anxiety. Anxiety, mood, sleep, and physical activity changed from 1 week before to competition day (all P < .001). One week before, state anxiety was higher with tension (β = 1.22, P < .001), fatigue (β = 1.49, P < .001), and confusion (β = 1.14, P < .001); trait anxiety was higher with anger (β = 1.15, P < .001), depression (β = 1.38, P < .001), and fatigue (β = 0.42, P = .004), and lower with confusion (β = -0.36, P = .009). State anxiety was positively associated with sleep disturbances (β = 5.94, P < .001); trait anxiety with poorer subjective sleep quality (β = 2.87, P < .001) and longer sleep latency (β = 0.26, P < .001). Vigorous MET-minutes predicted lower state anxiety (β = -0.009, P = .02) and walking predicted lower trait anxiety (β = -0.007, P = .007). State anxiety increased with confusion (β = 1.47, P < .001) and decreased with vigor (β = -0.94, P = .003); trait anxiety increased with depression (β = 1.53, P < .001) and fatigue (β = 1.34, P < .001). Daytime dysfunction predicted higher state anxiety (β = 8.91, P < .001) and sleep latency predicted higher trait anxiety (β = 0.10, P = .031). Moderate MET-minutes predicted higher state anxiety (β = 0.008, P = .02). Increases in state anxiety aligned with higher tension (β = 0.93, P < .001), fatigue (β = 0.61, P = .004), and confusion (β = 1.89, P < .001), and decreases with depression (β = -0.54, P = .02). Increases in trait anxiety were driven by depression (β = 1.67, P < .001) and fatigue (β = 1.06, P < .001). Greater daytime dysfunction predicted increases in state anxiety (β = 9.28, P < .001), whereas longer sleep latency (β = 0.19, P < .001) and shorter sleep duration (β = -3.18, P < .001) predicted increases in trait anxiety; activity changes were not significant. Competition anxiety in young karate athletes is chiefly associated with mood disturbances and sleep parameters; implementing mood-regulation and sleep-focused strategies may reduce anxiety in youth combat sports.</p>","PeriodicalId":18549,"journal":{"name":"Medicine","volume":"105 18","pages":"e48435"},"PeriodicalIF":1.4,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13138430/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147817318","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Trends in accidental poisoning and exposure to noxious substances involving drugs, medicaments, and biological substances-related deaths: A nationwide US analysis, 1999 to 2023.","authors":"Sujata Lodh, Muddassir Khalid, Amisha Kumari, Sumia Fatima, Rida Noor","doi":"10.1097/MD.0000000000048537","DOIUrl":"10.1097/MD.0000000000048537","url":null,"abstract":"<p><p>Unintentional poisoning and exposure to harmful substances involving illicit drugs, medications other than those taken as prescribed, and biological substances have emerged as a leading cause of preventable death in the United States. The increase in drug-specific toxicity, particularly from synthetic opioids, has accelerated during the COVID-19 pandemic, thus highlighting a need for national surveillance to monitor emerging demographic and geographic patterns. The CDC WONDER Multiple Cause of Death database provided mortality data from 1999 to 2023. Deaths with accidental poisoning (International Statistical Classification of Diseases and Health-Related Problems-10th Revision codes X40-X49) coded as the underlying cause and poisoning due to drugs (T36-T50) as multiple causes were considered. Age-adjusted mortality rates were extracted from the SEER database (number of deaths per 100,000 individuals). They were analyzed according to sex, age strata, race/ethnicity, and geographic region via Joinpoint regression for estimation of annual percentage change and average annual percentage change, with statistical significance set at P < .05. From 1999 to 2023, all-ages age-adjusted mortality rates more than sextupled, from 4.8 (95% confidence interval: 4.7-4.9) to 30.8 (95% confidence interval: 30.6-31.0). The consistently higher male mortality culminated in 2022, where men had a crude mortality of 45.3 per million compared with 18.2 per million in women. The largest increase was from 2019 to 2020, after the start of the COVID-19 pandemic. It is most severe among middle-aged adults (ages 45-64) and is characterized by geographic disparities in mortality, with clustering in counties across the Appalachian region and Southern United States. Non-Hispanic Black and American Indian/Alaska Native people experienced the latest spikes in mortality. The ongoing rise in drug-related accidental poisonings indicates a growing, evolving epidemic in the United States. The findings identified a need for focused equity-based interventions targeting substance use treatment, social determinants of health, and enhanced surveillance to address the escalating burden of mortality due to drug toxicity.</p>","PeriodicalId":18549,"journal":{"name":"Medicine","volume":"105 18","pages":"e48537"},"PeriodicalIF":1.4,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13138426/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147817332","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Factors influencing poor knee function 1 year after anterior cruciate ligament reconstruction and development and validation of a nomogram prediction model.","authors":"Jun-Feng Lu, Bing Deng, Li Yin, Shuang Yang, Jing Yang, Xian-Yun Qin, Min Yin","doi":"10.1097/MD.0000000000048534","DOIUrl":"10.1097/MD.0000000000048534","url":null,"abstract":"<p><p>This study aimed to investigate risk factors associated with poor knee function 1 year after anterior cruciate ligament (ACL) reconstruction, develop a prediction model, and validate it. Clinical data of patients undergoing ACL reconstruction at the General Hospital of the Western Theater Command of the People's Liberation Army, PLA, from January 2022 to December 2024 were retrospectively reviewed. Univariate and multivariate logistic regression analyses identified independent factors influencing poor knee function at 1 year postoperatively. A nomogram was developed to visualize the predictive model. The model's discriminatory performance was evaluated using receiver operating characteristic curves and area under the curve, while model fit was assessed via the Hosmer-Lemeshow test. To enhance validation reliability, internal validation was conducted using Bootstrap and 10-fold cross-validation. Clinical applicability was evaluated through calibration curves and decision curves. A total of 647 patients undergoing ACL reconstruction were included, among whom 133 developed poor knee function, yielding an incidence rate of 20.56%. Univariate and multivariate logistic regression analyses identified 5 independent risk factors for poor knee function at 1 year postoperatively: meniscus injury (OR, 2.098; 95% CI, 1.508-3.016), body mass index ≥ 25 kg/m2 (OR, 1.902; 95% CI, 1.442-2.342), poor compliance (OR, 3.618; 95% CI, 2.733-4.259), insufficient quadriceps strength recovery (OR, 2.936; 95% CI, 2.345-4.502), and graft diameter < 8 mm (OR, 2.635; 95% CI, 2.198-3.430). Receiver operating characteristic curve analysis, Hosmer-Lemeshow test, and Bootstrap combined with 10-fold cross-validation confirmed the model's excellent discriminatory ability, fitting performance, stability, and high clinical value. Poor knee function 1 year after ACL reconstruction is influenced by multiple factors. The nomogram prediction model developed in this study demonstrates high accuracy, aiding clinicians in early identification of high-risk patients for timely intervention.</p>","PeriodicalId":18549,"journal":{"name":"Medicine","volume":"105 18","pages":"e48534"},"PeriodicalIF":1.4,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13138459/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147817393","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A case of resistance to thyroid hormone beta and literature review: Case report.","authors":"Zirao Yang, Shuang Ma, Yuehua Dong, Xi Tian, He Wang","doi":"10.1097/MD.0000000000048504","DOIUrl":"10.1097/MD.0000000000048504","url":null,"abstract":"<p><strong>Rationale: </strong>Resistance to thyroid hormone (RTH) syndrome is an uncommon disorder of thyroid function that is frequently misdiagnosed or overlooked clinically. We identified a heterozygous mutation in the THRβ gene (c.1357C > A [p.Pro453Thr]) in a patient with resistance to thyroid hormone beta. This locus variation has rarely been reported domestically or internationally.</p><p><strong>Patient concerns: </strong>The patient, a 13-year-old female presenting with goiter, was found to have persistent high free triiodothyronine and free thyroxine levels with a non-suppressed thyroid-stimulating hormone in the absence of classic hyperthyroid symptoms.</p><p><strong>Diagnoses: </strong>Based on the patient's history, physical examination, imaging studies, and genetic testing, the diagnosis of resistance to thyroid hormone was definitively established.</p><p><strong>Interventions: </strong>The medication was discontinued based on the patient's clinical status. The management plan was transitioned to a strategy of watchful waiting, with scheduled follow-ups to monitor the patient's status.</p><p><strong>Outcomes: </strong>Following a genetic diagnosis, the patient has been followed for 24 months under an active surveillance strategy, which includes annual thyroid function tests.</p><p><strong>Lessons: </strong>Enhanced clinical vigilance is imperative to mitigate diagnostic bias and errors associated with this condition, thereby ensuring timely and accurate diagnosis and appropriate therapeutic intervention.</p>","PeriodicalId":18549,"journal":{"name":"Medicine","volume":"105 18","pages":"e48504"},"PeriodicalIF":1.4,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13138390/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147817394","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A bibliometric review of peripherally inserted central catheters: Knowledge domain mapping and research trends.","authors":"Zhouyuan Wei, Fuqiang Tang, Limei Wang, Yuan Gui, Limei Hou, Jing Zhang","doi":"10.1097/MD.0000000000048516","DOIUrl":"10.1097/MD.0000000000048516","url":null,"abstract":"<p><strong>Background: </strong>Peripherally inserted central catheters (PICCs) are commonly used vascular access devices in clinical practice. Due to their numerous advantages, PICCs are widely used globally. However, after decades of iteration and clinical application, while benefiting patients, PICCs also face new opportunities and challenges. Therefore, this study systematically analyzes the current status of global PICCs research through bibliometric methods and predicts future research directions and hotspots, aiming to provide references for further development and innovation of PICCs.</p><p><strong>Methods: </strong>CiteSpace, VOSviewer, and the bibliometrix R-package were used to perform descriptive statistics and data visualization analyses on literature from the Web of Science Core Collection. A total of 2102 articles were selected, originating from 2722 institutions across 105 countries.</p><p><strong>Results: </strong>The United States has the greatest influence in the field of PICC research, with the Michigan Health System being the most prolific institution, and Vineet Chopra being the most influential scholar. Keyword and co-citation analysis reveal hot topics: PICC catheterization techniques, complications, and clinical quality control of PICCs.</p><p><strong>Conclusion: </strong>Research on PICCs is showing trends of global collaboration and interdisciplinary approaches. Artificial intelligence and other medical auxiliary technologies demonstrate great potential in addressing PICC complications and insertion challenges. Establishing efficient vascular access teams and solving PICC care issues based on evidence-based practices are crucial for ensuring quality control during PICC usage.</p>","PeriodicalId":18549,"journal":{"name":"Medicine","volume":"105 18","pages":"e48516"},"PeriodicalIF":1.4,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13138443/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147817412","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Feasibility study on the effect and complications of intravenous therapy nursing intervention on patients with PICC catheterization.","authors":"Lanxin Guo, Wenshu Zhang, Tingting Hu, Haiying Xu","doi":"10.1097/MD.0000000000047761","DOIUrl":"10.1097/MD.0000000000047761","url":null,"abstract":"<p><p>The peripherally inserted central catheter (PICC) has been widely used in clinical practice, but there are also high risks in the use process. With the development of intravenous therapy technology, it is possible to reduce PICC related adverse events. This study aims to explore the effect of specialized nursing intervention of intravenous therapy in patients with PICC and the feasibility of preventing/reducing complications. Subjects 23 to 75 years treated with PICC catheterization concluded. A total of 96 subjects were assigned to a control group (n = 48), which performed routine care, a study group (n = 48), which received 2-week intravenous therapy specialist nursing therapy based on routine care. After 2 weeks for PICC nursing therapy, Chi square test analyses showed significant differences between routine care (75.00%) and intravenous therapy specialist nursing therapy (93.75%) in treatment compliance rate, as well as the scores of Cancer Patients PICC Sell management and the core scale of quality of life of cancer patients. Significantly lower incidence of complications for study group (8.33%) versus control group (27.08%). Intravenous therapy specialist nursing intervention has a significant effect on patients with PICC catheterization, which can improve patients' treatment compliance, improve their quality of life, and effectively reduce the occurrence of related complications.</p>","PeriodicalId":18549,"journal":{"name":"Medicine","volume":"105 18","pages":"e47761"},"PeriodicalIF":1.4,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13138419/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147817387","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Enhanced tumor control in non-small cell lung cancer using intensity-modulated radiotherapy combined with microwave hyperthermia: A retrospective study.","authors":"Wei Li, Xiangdong Liu, Wenyong Chen","doi":"10.1097/MD.0000000000048529","DOIUrl":"10.1097/MD.0000000000048529","url":null,"abstract":"<p><p>This study aimed to investigate the enhanced tumor control in patients with non-small cell lung cancer (NSCLC) using intensity-modulated radiotherapy (IMRT) combined with microwave hyperthermia (MWD). We retrospectively analyzed the clinical data of 134 patients with NSCLC admitted to our hospital from March 2021 to February 2024. Among them, 66 patients received IMRT alone (IMRT group) and 68 patients received IMRT combined with MWD (combined group). Tumor control rates, serum tumor markers, immune function, and toxic side effects were evaluated. The tumor control rate was significantly higher in the combined group (82.35%) than in the IMRT group (69.70%; P < .05). After treatment, the combined group showed significantly lower levels of carbohydrate antigen 125 (CA125), cytokeratin 19-fragments (Cyfra21-1), and carcinoembryonic antigen (CEA) compared to the IMRT group (P < .05). Furthermore, the levels of CD3+, CD4+, and CD4+/CD8+ ratios in the combined group were significantly higher than those in the IMRT group (P < .05). No significant difference in toxic side effects was observed between the 2 groups (P > .05). IMRT combined with MWD for NSCLC can effectively downregulate tumor markers, restore immune function, and improve tumor control rates without increasing toxicity.</p>","PeriodicalId":18549,"journal":{"name":"Medicine","volume":"105 18","pages":"e48529"},"PeriodicalIF":1.4,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13138467/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147817235","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}