Medicine最新文献

{"title":"The Role of Autoflorescence Imaging Device in the Evaluation of Bacteria Burden Control.","authors":"Agata Janowska, Giulia Davini, Michela Iannone, Cristian Fidanzi, Riccardo Morganti, Marco Romanelli, Valentina Dini","doi":"10.1177/15347346221098514","DOIUrl":"10.1177/15347346221098514","url":null,"abstract":"<p><p>MolecuLight i:X is a autofluorescence, portable device that allows an assessment of wound area, perimeter, width and length and an evaluation in real time of wound surface bacteria (>104 CFU/g). Primary objective of our study was to evaluate the reduction of bacterial load associated to 3 different therapeutic approaches: dressings and multicomponent bandages (Group1), sharp debridement, dressings and multicomponent bandages (Group 2), and 10 patients treated with zinc oxide bandage (Group 3). Secondary objective was NRS pain scale, Wound Bed Score (WBS) and Quality of Life (QoL) assessment. Despite the improvement of bacterial load, WBS, Qol and NRS was evident in all 3 groups, the analysis of our results demonstrates that the application of zinc oxide bandage, directly in contact with the wound bed and/or the perilesional skin, resulted in a higher improvement and a significant reduction of WBS and bacterial load. Fluorescence imaging can help the specialist in a more targeted assessment and management of infection. Sharp debridement and antiseptic dressings are classically used to reduced bacteria burden. Zinc oxide directly on the wound is an interesting cost-effective option to control different types of bacteria.</p>","PeriodicalId":18549,"journal":{"name":"Medicine","volume":"10 1","pages":"409-414"},"PeriodicalIF":1.3,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"77950468","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Assessing the efficacy and safety of low dose clopidogrel in Chinese ACS patients undergoing PCI: A retrospective study.","authors":"Biao Cheng, Xianghai Kong, Jian Chen, Qin He, Mi Zhou, Aiping Deng","doi":"10.1097/MD.0000000000042551","DOIUrl":"https://doi.org/10.1097/MD.0000000000042551","url":null,"abstract":"<p><p>Continuation of single antiplatelet treatment (SAPT) is recommended for patients with acute coronary syndromes (ACS) undergoing percutaneous coronary intervention (PCI) after dual antiplatelet treatment (DAPT). However, the optimal long-term SAPT remains unclear for these patients. The retrospective study recruited ACS patients who underwent PCI and chosen clopidogrel to SAPT after DAPT between 01/2014 and 12/2016 at the Central Hospital of Wuhan, Wuhan, China. Patients were divided into 2 groups after standard DAPT: low dose group (clopidogrel, 50 mg/d) and control group (clopidogrel, 75 mg/d). Among 378 enrolled patients with ACS undergoing PCI, 49/378 (14.5%) were taking 50 mg clopidogrel after DAPT. At the mean follow-up of 34 months, the cumulative incidence of the primary outcomes (hazard ratio [HR] 1.345, 95% CI: 0.455-3.974; P = .592), secondary outcome (HR 1.483, 95% CI: 0.506-4.348; P = .473), and safety outcomes (HR 2.268, 95% CI: 0.835-6.160; P = .108) showed no significant differences between the 2 group. Propensity score-matched analysis confirmed these findings. A 50 mg maintenance dose of clopidogrel may be comparable to 75 mg clopidogrel for Chinese patients with ACS undergoing PCI after at least 12 months of DAPT in efficacy and safety.</p>","PeriodicalId":18549,"journal":{"name":"Medicine","volume":"104 22","pages":"e42551"},"PeriodicalIF":1.3,"publicationDate":"2025-05-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144180288","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The relationship between insulin resistance and recurrent pregnancy loss in assisted reproductive technology: A retrospective case-control study.","authors":"Yacong Cao, Miao Ding, Jingbo Chen, Chaofan Zhang, Fengyi He, Xiaojia Li, Sushi Jiang, Yanting Zou, Dongzi Yang, Xiaomiao Zhao","doi":"10.1097/MD.0000000000042373","DOIUrl":"https://doi.org/10.1097/MD.0000000000042373","url":null,"abstract":"<p><p>This study aimed to investigate the association between insulin resistance (IR) and recurrent pregnancy loss (RPL) in patients undergoing assisted reproductive technology (ART). A retrospective analysis compared glucose and insulin indices (including fasting insulin [FINS], Homeostatic Model Assessment for Insulin Resistance [HOMA-IR], Homeostatic Model Assessment for Beta-Cell Function [HOMA-β], and area under the curve for insulin [AUCI] between RPL (n = 279) and non-RPL (n = 246) groups. Adjusted logistic regression models evaluated the correlation between IR-related indices and RPL risk. Compared with the non-RPL group, the RPL group exhibited significantly higher levels of FINS (10.67 vs. 8.57; P < .001), 1-hour insulin (1hINS) (110.86 vs. 74.75; P = .005), 2-hour insulin (2hINS) (89.47 vs. 67.94, P = .023), AUCI (117.08 vs. 114.16; P = .004), HOMA-IR (2.5 vs. 1.94; P < .001), HOMA-β (138.31 vs. 107.84; P < .001), the incidence of insulin resistance (63.47% vs. 47.03%; P < .001), and the incidence of HOMA-IR ≥ 2.14 (61.9% vs. 40.27%; P < .001). After adjusting for other factors, patients with IR had a higher risk of developing RPL compared with those without IR, with an odds ratio (OR) of 1.87 (95% CI: 1.18-2.94). Furthermore, an increase in FINS, HOMA-IR, and HOMA-β was associated with a significantly higher incidence of RPL, with OR values (95% CI) of 1.07 (1.03-1.12), 1.23 (1.03-1.48), and 1.01 (1.0-1.01), respectively. IR is an independent risk factor for RPL in ART patients, emphasizing the need for pretreatment interventions (e.g., lifestyle modifications or metformin) to improve insulin sensitivity and reduce miscarriage risk.</p>","PeriodicalId":18549,"journal":{"name":"Medicine","volume":"104 22","pages":"e42373"},"PeriodicalIF":1.3,"publicationDate":"2025-05-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144180405","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Identification of key genes regulating colorectal cancer stem cell characteristics by bioinformatics analysis.","authors":"Jing Lu, Haotian Zhang, Xiaoyu Gu, Yonghui Liu, Chengwen Zhao, Xudong Wang","doi":"10.1097/MD.0000000000040910","DOIUrl":"https://doi.org/10.1097/MD.0000000000040910","url":null,"abstract":"<p><p>Cancer stem cells (CSCs), distinguished by their abilities to differentiate and self-renew, play a pivotal role in the progression of colorectal cancer (CRC). However, the mechanisms that sustain CSCs in CRC remain unclear. This study aimed to identify and characterize gene expressions associated with CRC stemness. We applied a 1-class logistic regression machine learning model to calculate the mRNA expression-based stemness index (mRNAsi) for CRC samples from The Cancer Genome Atlas and cBioPortal databases, adjusting the mRNAsi by tumor purity. Clinical features of CRC were considered in assessing both mRNAsi and adjusted mRNAsi levels. Using DESeq2, we screened differentially expressed genes between high and low mRNAsi groups. Enrichment analysis provided functional annotation for these differentially expressed genes. Key genes linked to mRNAsi were identified using the Kaplan-Meier plotter and Cytoscape software, followed by an evaluation of their prognostic significance. Potential small-molecule compounds targeting the CRC stemness signature were explored via L1000FWD, DGIdb, and CMap databases. CRC samples with higher mRNAsi or adjusted mRNAsi values showed improved disease-free survival (DSS) and progression-free survival (PFS). Strong correlation between clinical characteristics of CSCs and mRNAsi was observed; CMS4 subtype CRC patients had lower mRNAsi with worse DSS and PFS. Ten key genes associated with mRNAsi were identified: collagen type I alpha 1, fibrillin 1, matrix metalloproteinase 9, SPP1, BGN, COL5A1, FN1, elastin, matrix metalloproteinase 2, collagen type I alpha 2. Lower expression of these genes correlated with better PFS and DSS. High correlation among these genes was confirmed in the protein-protein interaction network. This study identifies potential small-molecule drugs targeting stemness in CRC and highlights the prognostic value of the 10 key genes, offering insights into therapeutic targets for CRC treatment.</p>","PeriodicalId":18549,"journal":{"name":"Medicine","volume":"104 22","pages":"e40910"},"PeriodicalIF":1.3,"publicationDate":"2025-05-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144180763","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"HALP score and GNRI: Simple and powerful prognostic markers in diffuse large B-cell lymphoma.","authors":"Tugba Cetintepe, Lutfi Cetintepe, Demet Kiper Unal, Kemal Aygun, Serife Solmaz","doi":"10.1097/MD.0000000000042165","DOIUrl":"https://doi.org/10.1097/MD.0000000000042165","url":null,"abstract":"<p><p>Diffuse large B cell lymphoma (DLBCL) is the most common subtype of non-Hodgkin lymphoma. It is a heterogeneous group of diseases that may need very aggressive treatment in some cases. Prognostic evaluation is very important in determining the best treatment. However, in some clinics, access to genetically based and expensive diagnostic methods is limited. In this study, we analyzed the prognostic value of Hemoglobin, Albumin, Lymphocyte and Platelet (HALP) Score and Geriatric Nutritional Risk Index (GNRI) in DLBCL patients. 201 Patients with newly diagnosed DLBLC between 2005 and 2022 were retrospectively evaluated. Optimal cutoff points for the HALP score and the GNRI were calculated with the receiver operating characteristic curve analysis. Kaplan-Meier method was used to compare survival and disease-free survival times between HALP score groups. In the receiver operating characteristic curve analysis, the cutoff points were found 26.17 for HALP, and 99.17 for GNRI. Groups with lower HALP scores and lower GNRIs had significantly shorter overall survival and disease-free survival. Univariate analyses showed that lower HALP score, lower GNRI and higher lactic dehydrogenase, Ann-Arbor stage, International Prognostic Index (IPI), National Comprehensive Cancer Network-IPI and Revised-IPI scores were associated with worse survival rates (P < .05). According to the results of the multivariate Cox regression model, patients with HALP score ≤ 26.17 (OR: 2.32; 95%CI: 1.31-4.11 P = .004) increased the risk of death (P = .001, -2 loglikelihood = 506.15). Similarly, a GNRI score ≤ 99.17 was significantly correlated with worse survival outcomes (P < .001). HALP score and GNRI score are reliable, simple and easily accessible indices that can be used to predict the prognosis of DLBLC patients. DLBLC patients with low HALP score and low GNRI level may be associated with short survival and early nutritional support should be considered.</p>","PeriodicalId":18549,"journal":{"name":"Medicine","volume":"104 22","pages":"e42165"},"PeriodicalIF":1.3,"publicationDate":"2025-05-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144180866","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effect of mindfulness-based cognitive therapy on rumination and post-traumatic growth in patients with acute cerebral infarction: A randomized controlled trial.","authors":"Zuoju Zhang, Yanhong Dong, Yuxin Sun","doi":"10.1097/MD.0000000000042570","DOIUrl":"https://doi.org/10.1097/MD.0000000000042570","url":null,"abstract":"<p><strong>Background: </strong>The prevention and management of cerebrovascular diseases, particularly cerebral infarction - the most prevalent type of cerebrovascular disease - pose significant challenges, severely affecting patients' physical and mental health. Mindfulness-based cognitive therapy (MBCT) has been shown to be effective in treating various mental and chronic conditions. However, there is limited evidence on its effectiveness for treating rumination in patients with acute cerebral infarction (ACI). This study examines the effects of MBCT on rumination, anxiety and depression symptoms, post-traumatic growth, self-care ability, limb motor function, and muscle strength in patients with ACI.</p><p><strong>Methods: </strong>In this randomized, single-blind, parallel, single-center controlled trial, participants were recruited from the Department of Neurology and allocated randomly to either 6 weeks of mindfulness cognitive therapy or standard care. The outcomes were assessed at baseline and post-intervention (6 weeks) using the simplified Chinese event-related rumination inventory, the hospital anxiety and depression scale, the simplified Chinese post-traumatic growth inventory, the modified Barthel index (MBI), Brunnstrom hemiplegic motor function assessment, and the Lovett Muscle strength scale.</p><p><strong>Results: </strong>Ninety-five subjects were randomly sorted into either the intervention (n = 48) or control group (n = 47). During the study, 5 (5.26%) participants were lost to follow-up, leaving 90 (94.74%) to complete the intervention. Post-intervention, both groups exhibited increased total and purposive rumination scores, with the intervention group scoring higher (P < .05). Intrusive rumination decreased in both groups, with a more significant reduction observed in the intervention group (P < .05). Both groups showed reduced hospital anxiety and depression scores, though the intervention group had lower scores (P < .05). The intervention group also had higher total and subscale scores for post-traumatic growth than the control (P < .05). The MBI scores improved in both groups, with the intervention group showing higher scores (P < .05). However, no significant difference was observed in the improvement of limb motor function or muscle strength between the intervention and conventional care groups (P > .05).</p><p><strong>Conclusion: </strong>MBCT can improve the purposeful rumination and self-care ability of patients with ACI, alleviate anxiety and depression symptoms, and foster post-traumatic growth. However, it did not significantly improve limb motor function or muscle strength.</p>","PeriodicalId":18549,"journal":{"name":"Medicine","volume":"104 22","pages":"e42570"},"PeriodicalIF":1.3,"publicationDate":"2025-05-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144181688","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The relationship between emotional labor and job burnout among Chinese medical staff: The mediating role of organizational identification.","authors":"Tianhao Yang, Zihe Zhao, Jiawen Zhu, Qianling Huang, Yuanyuan Zhu, Zhi Zeng, Yan Liu","doi":"10.1097/MD.0000000000042598","DOIUrl":"https://doi.org/10.1097/MD.0000000000042598","url":null,"abstract":"<p><p>This study investigates the relationships and underlying mechanisms among emotional labor, organizational identification, and job burnout in medical staff. A convenience sampling method was employed to conduct a questionnaire survey among 419 medical staff members. The Emotional Labor Scale, Organizational Identification Scale, and Maslach Burnout Inventory-General Survey were utilized for data collection. Statistical software SPSS 26.0 and AMOS 25.0 were used for data analysis, and a structural equation model with organizational identification as a mediator was ultimately constructed. The results revealed that the scores for surface acting, deep acting, organizational identification, and job burnout among medical staff were (16.15 ± 4.55), (10.94 ± 2.26), (25.80 ± 3.55), and (28.76 ± 9.12), respectively. Surface acting was negatively correlated with organizational identification (r = -0.43, P < .01) and positively correlated with job burnout (R = 0.49, P < .01). Deep acting was positively correlated with organizational identification (R = 0.38, P < .01) and negatively correlated with job burnout (r = -0.38, P < .01). Organizational identification was negatively correlated with job burnout (r = -0.67, P < .01). Organizational identification partially mediated the relationships between both surface acting and deep acting with job burnout by accounting for 40.82% and 52.20% of the total effects, respectively. Hospital managers can enhance the quality of medical services by developing effective strategies to reduce job burnout among medical staff through promoting their engagement in deep acting behaviors as well as fostering their sense of organizational identification. The study is constrained by its cross-sectional design, self-reported data bias, and regional sample limitations. Therefore, the generalizability of the findings requires further validation through multi-dimensional data.</p>","PeriodicalId":18549,"journal":{"name":"Medicine","volume":"104 22","pages":"e42598"},"PeriodicalIF":1.3,"publicationDate":"2025-05-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144181854","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Causal relationships between 91 inflammatory cytokines and gastroesophageal reflux disease, and the mediating role of related metabolites: Evidence from genetics.","authors":"Liqun Li, Lijian Liu, Jieru Xie, Chengning Yang, Guangwen Chen, Jinjing Tan, Xiaoyan Huang, Sheng Xie","doi":"10.1097/MD.0000000000042426","DOIUrl":"https://doi.org/10.1097/MD.0000000000042426","url":null,"abstract":"<p><p>The associations between specific inflammatory cytokines and gastroesophageal reflux disease (GERD) have been confirmed, while their causal relationships remain unclear. We conducted a bidirectional 2-sample Mendelian randomization analysis (MRA) to reveal the causal correlations between 91 inflammatory factors and GERD, thereby conducting a 2-step MRA analysis to reveal the mediating function of 1400 metabolites therein. Data related to 91 inflammatory cytokines were derived from Genome-Wide Association Studies (GWAS) data with 14,824 samples. GWAS data about GERD were obtained from a large genome research project in Finland, including 28,859 GERD cases and 3,50,064 controls. GWAS data about 1400 circulating metabolites were derived from a cohort of 8299 individuals. The inverse variance weighted approach was introduced to obtain the primary MRA results, complemented by 4 additional methods for supportive analyses. Additionally, the study conducted sensitivity analyses with different methods to evaluate heterogeneity and horizontal pleiotropy. Our findings indicated that higher predicted C-X-C motif chemokine 1 [OR = 1.052, 95% CI: 1.004 - 1.103, P = .035], interleukin-1-alpha [OR = 1.083, 95% CI: 1.018 - 1.152, P = .012], and interleukin-4 [IL-4, OR = 1.081, 95% CI: 1.018 - 1.147, P = .011] increased the risk of GERD; whereas tumor necrosis factor ligand superfamily member 12 [OR = 0.958, 95% CI: 0.9174-0.9999, P = .0493] decreased the risk of GERD. No significant statistical differences were found for other inflammatory cytokines. Genetic susceptibility to GERD had no impact on any traits related to circulating inflammatory cytokines. Four metabolites associated with elevated IL-4 levels were identified, including (1-enyl-oleoyl)-GPE (P-18:1), 4-methyl guaiacol sulfate, X-12730, and X-17685, but their mediating effects were not statistically significant (P > .05). This study convincingly proved the causal impact of inflammatory factors on GERD. It confirms that C-X-C motif chemokine 1, interleukin-1-alpha, and IL-4 increase the risk of GERD, while tumor necrosis factor ligand superfamily member 12 reduces it. Additionally, several circulating metabolites are associated with elevated IL-4 levels. However, the evidence for their role as potential mediators in the pathway between IL-4 and GERD risk remains insufficient. The findings of this study propel further comprehension of the pathogenesis of GERD and also point out the therapeutic potential for interventions targeting inflammatory cytokine-targeted inventions.</p>","PeriodicalId":18549,"journal":{"name":"Medicine","volume":"104 22","pages":"e42426"},"PeriodicalIF":1.3,"publicationDate":"2025-05-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144182417","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Construction of a nomogram for predicting the risk of primary liver cancer occurrence in patients with liver cysts using CT imaging features combined with alpha-fetoprotein.","authors":"Ze-Long Jin, Li-Jun Zhao","doi":"10.1097/MD.0000000000042719","DOIUrl":"https://doi.org/10.1097/MD.0000000000042719","url":null,"abstract":"<p><p>This study aimed to explore the predictive value of a nomogram model, constructed using computed tomography (CT) imaging proteomics combined with alpha-fetoprotein (AFP), for assessing the risk of primary liver cancer (PLC) occurrence in patients with liver cysts. A retrospective analysis was conducted on 122 individuals with liver cysts who visited Shengzhou People's Hospital between May 2021 and October 2022. Patients were categorized into 2 groups based on the occurrence of PLC: the PLC group (n = 40) and the cyst group (n = 82). The study compared differences in AFP expression and CT imaging features between the 2 groups. The \"rms\" package in R software was utilized to develop and validate a nomogram model for predicting the risk of PLC occurrence in patients with liver cysts. The PLC group exhibited higher proportions in family history of liver cancer, chronic hepatitis B virus (HBV) infection, and AFP (≥400 ng/mL) levels compared to the cyst group, with statistically significant differences (P < .05). In terms of CT imaging features, patients in the PLC group had larger maximum diameters, lower rates of clear margins, and higher CT values in the arterial and venous phases compared to those in the cyst group (P < .05). Logistic regression analysis identified chronic HBV infection, AFP (≥400 ng/mL), and CT values in the arterial and venous phases as influencing factors for PLC occurrence in patients with liver cysts (P < .05). The constructed nomogram exhibited a mean absolute error of 0.020 for predicting the risk of PLC occurrence in patients with liver cysts. The receiver-operating characteristic curve analysis showed an area under the curve of 0.829 (95% CI: 0.754-0.905). Chronic HBV infection, AFP (≥400 ng/mL), and CT values in the arterial and venous phases were significant factors influencing the occurrence of PLC in patients with liver cysts. The nomogram based on these factors demonstrated promising predictive efficacy for PLC occurrence in patients with liver cysts, providing valuable guidance for preventive and treatment strategies.</p>","PeriodicalId":18549,"journal":{"name":"Medicine","volume":"104 22","pages":"e42719"},"PeriodicalIF":1.3,"publicationDate":"2025-05-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144182516","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Gitelman syndrome with hypercalcemia and normomagnesemia: A case report.","authors":"Zhenlin Tan, Chen Liu, Zheng Feng, Zhimei Luo, Xiaofen Lian, Donghui Lu","doi":"10.1097/MD.0000000000042610","DOIUrl":"https://doi.org/10.1097/MD.0000000000042610","url":null,"abstract":"<p><strong>Rationale: </strong>Gitelman syndrome (GS) is a rare autosomal recessive renal tubular disease, whose main symptoms are long-term hypokalemia, hypomagnesemia, hypochloremic metabolic alkalosis, and hypocalciuria.</p><p><strong>Patient concerns: </strong>This study reported a GS patient with hypercalcemia combined with normomagnesemia.</p><p><strong>Diagnoses: </strong>GS with hypercalcemia.</p><p><strong>Interventions: </strong>The patient was treated with a 20 mg spironolactone tablet 2 times/day and a 1 g potassium chloride sustained-release tablet 3 times/day for potassium preservation.</p><p><strong>Outcomes: </strong>The patient received regular individualized long-term potassium supplementation and was followed regularly.</p><p><strong>Lessons: </strong>GS is an extremely rare disease, which is characterize by long-term hypokalemia, hypomagnesemia, hypochloremic metabolic alkalosis, and hypocalciuria. But the case reported here combined with hypercalcemia and normomagnesemia. Clinical physicians should increase their awareness of this disease to enable early diagnosis and treatment of GS and reduce missed diagnoses.</p>","PeriodicalId":18549,"journal":{"name":"Medicine","volume":"104 22","pages":"e42610"},"PeriodicalIF":1.3,"publicationDate":"2025-05-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144183257","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}