Medicine最新文献

{"title":"The effectiveness of the Chinese Five-Element Music intervention on older adults with depression and anxiety disorder: A systematic review and meta-analysis.","authors":"Jiayin Li, Kanghao Chen, I Ta Wang, Wen Fen Beh","doi":"10.1097/MD.0000000000044764","DOIUrl":"10.1097/MD.0000000000044764","url":null,"abstract":"<p><strong>Background: </strong>Depression and anxiety are among the most prevalent mood disorders worldwide, affecting hundreds of millions of people and contributing to significant disability, particularly in older adults. Conventional treatments such as pharmacotherapy and psychotherapy are effective but often limited by side effects or accessibility. As a complementary approach, Chinese Five-Element Music (CFEM), rooted in Traditional Chinese Medicine, aims to restore emotional balance through the connection between musical tones, organ systems, and emotions. Recent studies suggest its potential to alleviate psychological symptoms, yet evidence in older populations remains limited.</p><p><strong>Methods: </strong>The systematic review identified and mapped available literature on CFEM interventions, guiding the selection and analysis of randomized controlled trials (RCTs) for meta-analysis. Databases including Web of Science, PubMed, CNKI, Wanfang, and CQVIP were searched in March 2025. Eighteen RCTs were included. Outcome measures assessed included the Hamilton Depression Rating Scale (HAMD), Hamilton Anxiety Rating Scale (HAMA), Zung Self-Rating Depression and Anxiety Scales (SDS and SAS), Pittsburgh Sleep Quality Index (PSQI), overall response rate (ORR), and Quality of Life (QOL). The risk of bias was assessed using the Cochrane Handbook criteria. Most studies reported adequate randomization, but blinding methods were often unclear.</p><p><strong>Results: </strong>A meta-analysis using a random-effects model was conducted on 18 RCTs. The results indicated that, compared to conventional care, the CFEM intervention significantly alleviated symptoms in older adults with depression and anxiety. Specifically, the outcomes were as follows: HAMD score (MD = -3.63, 95% CI: -4.97 to -2.3, P < .00001), HAMA score (MD = -3.89, 95% CI: -5.80 to -1.97, P < .0001), SAD score (MD = -6.69, 95% CI: -8.32 to -5.07, P < .00001), SAS score (MD = -6.84, 95% CI: -10.76 to -2.92, P = .0006), ORR score (95% CI: 1.61 to 4.89, P = .0003), QOL score (MD = -0.58, 95% CI: -15.65 to 14.48, P = .94), PSQI score (MD = -1.86, 95% CI: -2.54 to -1.17, P < .00001).</p><p><strong>Conclusion: </strong>CFEM may be an effective complementary intervention to alleviate depression, anxiety, and sleep problems in older adults. However, due to moderate study quality and lack of blinding, further high-quality trials are needed.</p>","PeriodicalId":18549,"journal":{"name":"Medicine","volume":"104 40","pages":"e44764"},"PeriodicalIF":1.4,"publicationDate":"2025-10-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12499668/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145238943","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The clinical significance of p53 and vascular endothelial growth factor in COVID-19 cases.","authors":"Suat Sincan, Gülden Sincan, İstemi Serin, Çağri Kiziltunç, Seda Aşkin","doi":"10.1097/MD.0000000000044378","DOIUrl":"10.1097/MD.0000000000044378","url":null,"abstract":"<p><p>Vascular endothelial growth factor (VEGF) plays a critical role in increasing the release of pro-inflammatory cytokines, endothelial cell proliferation, and regulating vascular permeability in COVID-19 cases. p53 regulates cellular stress responses. However, the precise interplay and prognostic significance of p53 and vascular endothelial growth factor in the context of COVID-19 pathogenesis and disease progression, particularly concerning mortality outcomes, remain to be fully elucidated. We investigated vascular endothelial growth factor and p53 levels in COVID-19 patients and examined the relationship of these markers with the clinical course and prognosis of the disease. A total of 30 patients with COVID-19 and 30 individuals in the control group were examined. The clinical symptoms, laboratory parameters, and survival status of COVID-19 patients participating in the study were recorded. Vascular endothelial growth factor and p53 levels were analyzed using the ELISA method. A P-value of < 0.05 was considered statistically significant in statistical analyses. p53 levels were significantly higher in COVID-19 patients (859.19 ± 385.43 ng/L) compared to the control group (727.29 ± 440.49 ng/L) (P = .04). There was no significant difference in vascular endothelial growth factor levels between the patient (126.52 ± 75.7 ng/L) and control groups (169.2 ± 112.3 ng/L) (P = .22). In deceased patients, both p53 and vascular endothelial growth factor levels were significantly higher than in the control group (P < .001, P = .03, respectively). This study supports the prognostic roles of p53 and vascular endothelial growth factor levels in COVID-19 disease.</p>","PeriodicalId":18549,"journal":{"name":"Medicine","volume":"104 40","pages":"e44378"},"PeriodicalIF":1.4,"publicationDate":"2025-10-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12499705/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145238975","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The influence of knowledge about endocrine-disrupting chemicals on motivation for health behaviors and the mediating role of perceived illness sensitivity: A cross-sectional analysis of women in South Korea.","authors":"Myung Kyung Lee, Jihyun Oh","doi":"10.1097/MD.0000000000044909","DOIUrl":"10.1097/MD.0000000000044909","url":null,"abstract":"<p><p>Environmental endocrine disruptors (EDCs) are chemicals that disrupt the endocrine system and pose significant health risks. Perceived sensitivity to illness refers to the heightened susceptibility of an individual due to genetic or environmental factors. This study aims to examine how the awareness of women on EDCs influences their motivation to adopt health behaviors, focusing on the mediating role of perceived illness sensitivity. From October to November 2024, we conducted a cross-sectional survey of 200 adult women in Seoul and Gyeonggi Province, South Korea. Participants were recruited from community-based institutions and completed an online questionnaire assessing their EDCs knowledge, perceived illness sensitivity, and motivation for health behaviors. Data were analyzed using descriptive statistics, parametric tests (t-test, ANOVA) for normally distributed variables, and nonparametric tests (Mann-Whitney U, Kruskal-Wallis) for non-normally distributed variables. Pearson correlations and mediation analysis were also performed. The average knowledge score on EDCs was 65.9 (SD = 20.7). Perceived illness sensitivity averaged 49.5 (SD = 7.4), and health behavior motivation was 45.2 (SD = 7.5). Significant differences in EDCs knowledge, perceived illness sensitivity, and health behavior motivation were observed based on age, marital status, education level, and menopausal status. EDCs knowledge positively correlated with perceived illness sensitivity and motivation. Perceived illness sensitivity was also positively linked to motivation. Mediation analysis revealed that perceived sensitivity partially mediated the relationship between EDCs knowledge and motivation. These findings suggest that knowledge alone may not be sufficient to promote behavior change; cognitive and emotional awareness of illness risk plays a key mediating role. Therefore, effective interventions should combine education with strategies to enhance perceived illness sensitivity.</p>","PeriodicalId":18549,"journal":{"name":"Medicine","volume":"104 40","pages":"e44909"},"PeriodicalIF":1.4,"publicationDate":"2025-10-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12499794/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145238979","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Ferula asafoetida oleo-gum resin alleviates dyspepsia symptoms through modulation of microbiome-gut-brain axis: A randomized, double-blind, placebo-controlled study.","authors":"Syam Das S, Veena Rm, P A Aneesa, Sherin Joy Parappilly, Johannah Natinga Mulakal, Baby Chakrapani Ps, Krishnakumar Illathu Madhavamenon","doi":"10.1097/MD.0000000000044590","DOIUrl":"10.1097/MD.0000000000044590","url":null,"abstract":"<p><strong>Background: </strong>Functional dyspepsia (FD) is a prevalent gut-brain interaction disorder that adversely affects cognitive function. Current treatment options offer limited efficacy and are often associated with undesirable side effects. Hence, in this study, we evaluated the efficacy of a food-grade, self-emulsifying hydrogel formulation of Ferula asafoetida oleo-gum resin (ASF) in improving dyspepsia symptoms, cognitive function, sleep quality, and gut microbiota in individuals with FD symptoms.</p><p><strong>Methods: </strong>A randomized, double-blind, placebo-controlled trial was conducted with 62 participants diagnosed with FD symptoms. Subjects received 250 mg/d of ASF or placebo for 14 days. Outcome measures included the Leuven Postprandial Distress Scale, choice reaction time test, Bergen Insomnia Scale (BIS), Bristol Stool Form Scale, and gut microbiome profiling.</p><p><strong>Results: </strong>ASF treatment showed a significant time, treatment, and treatment × time effect for early satiety, bloating, and heart burn (P < .05). Further analysis of Leuven Postprandial Distress Scale data by Mann-Whitney U test provided the influence of ASF on days 1, 3, 7, and 14 which indicated a progressive improvement in the number of positive responders, especially for bloating, early satiety, and postprandial fullness (P < .05). ASF also significantly modulated the gut microbiota by decreasing the Firmicutes-to-Bacteroidetes ratio (71.9%; P < .001), enhancing alpha diversity (P < .05), enriching beneficial genera (e.g., Bacteroides, Prevotella), and reducing harmful taxa (e.g., Escherichia, Clostridia). Further, ASF demonstrated improvements in digestion and reduced constipation as indicated by the Bristol Stool Form Scale, with type 1 stools decreasing from 65% to 18% and type 2 from 35% to 7% by day 14. Neurocognitive assessments showed improved attention and focus (44% reduction in reaction time, P < .001), while BIS results indicated better sleep quality (ΔBIS = 10.89 ± 3.23, P < .001) on day 14.</p><p><strong>Conclusion: </strong>ASF demonstrated significant modulation of the microbiome-gut-brain axis, resulting in reduced dyspepsia symptom severity, enhanced cognitive performance, improved sleep quality, and better digestive outcomes. These findings support the potential of ASF as a safe and effective dietary supplement for gut and cognitive health in individuals with FD.</p>","PeriodicalId":18549,"journal":{"name":"Medicine","volume":"104 40","pages":"e44590"},"PeriodicalIF":1.4,"publicationDate":"2025-10-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12499811/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145238985","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Novel key genes in the pathogenesis of recurrent pelvic organ prolapse identified via bioinformatics analysis.","authors":"Wenhua Liu, Yue Zhang","doi":"10.1097/MD.0000000000045134","DOIUrl":"10.1097/MD.0000000000045134","url":null,"abstract":"<p><p>The causes of pelvic organ prolapse (POP) recurrence are sufficiently understood. Few studies have investigated the key genes of the recurrence of POP. In the present study, we screened the hub genes responsible for the recurrence of POP. The GSE28660 gene expression dataset contained microarray data of 4 recurrent POP and 4 primary POP uterosacral ligaments. We used the online gene expression omnibus microarray expression profiling dataset to identify differentially expressed genes. Further analyses of functional enrichment and protein-protein interaction networks (PPIs) were conducted, and key modules were identified. In the next step, we used the CIBERSORT algorithm to investigate differences in immune cell infiltration between recurrent and primary POP tissues. A total of 84 upregulated genes and 32 downregulated genes were identified. DNA microarray analysis of the human genome identified 116 genes associated with recurrence POP, and 2 hub genes, including cell death-inducing DFFA-like effector (CIDEA) and hemoglobin subunit delta (HBD), may contribute to the pathogenesis of recurrence POP, potentially providing diagnostic and therapeutic value.</p>","PeriodicalId":18549,"journal":{"name":"Medicine","volume":"104 40","pages":"e45134"},"PeriodicalIF":1.4,"publicationDate":"2025-10-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12499779/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145239009","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prourokinase for acute ischemic stroke: A meta-analysis of randomized controlled trials.","authors":"Deekshitha Alla, Rakshna Ramsundar, Gitanjali Boppana, Thanmayee Tummala, Hanisha Reddy Kukunoor, Riva Jayesh Shah, Snigdha Mandava, Ruth Getaneh Bayeh, Naga Keerthi Gangavarapu, Ram Prasanjith Reddy, Venkata Chandra Sekhar Yelchuri","doi":"10.1097/MD.0000000000044837","DOIUrl":"10.1097/MD.0000000000044837","url":null,"abstract":"<p><strong>Background: </strong>Use of current thrombolytic agents, such as alteplase, is limited by risks such as intracranial hemorrhage, short half-life, and complex dosing regimens. These drawbacks hinder their optimal use in ischemic stroke treatment. Prourokinase (Pro-UK), with its fibrin specificity and favorable safety profile, offers a promising alternative. This meta-analysis aims to comprehensively evaluate its efficacy and safety in improving clinical outcomes for stroke patients.</p><p><strong>Methods: </strong>A systematic literature review was conducted across PubMed, Scopus, and Web of Science from 1989 to 2024 in accordance with Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines. Data analysis and visualization were performed using ReviewManager (RevMan) with a random-effects model. Risk of bias was assessed using the Cochrane tool, publication bias using Egger's test, and cumulative meta-analysis via trial sequential analysis.</p><p><strong>Results: </strong>A total of 5 randomized controlled trials comprising 3812 participants were included in this meta-analysis. The pooled analysis revealed that Pro-UK did not result in a statistically significant improvement in clinical outcomes among stroke patients, as measured by the National Institutes of Health Stroke Scale at 24 hours (mean difference = 0.06; 95% confidence interval [CI]: -0.09 to 0.21), the modified Rankin Scale (risk ratio [RR] = 0.99; 95% CI: 0.96-1.03), and the Barthel index (RR = 1.00; 95% CI: 0.99-1.01). Additionally, while there was a trend toward a reduction in systemic intracranial hemorrhage in the Pro-UK group, this finding did not reach statistical significance (RR = 0.86; 95% CI: 0.43-1.72).</p><p><strong>Conclusion: </strong>While Pro-UK offers a theoretical advantage in reducing systemic bleeding due to its clot-specific action, current evidence does not significantly improve key clinical outcomes. The limited number and heterogeneity of existing randomized controlled trials underscore the need for more robust, large-scale trials to confirm its safety and efficacy in acute ischemic stroke.</p>","PeriodicalId":18549,"journal":{"name":"Medicine","volume":"104 40","pages":"e44837"},"PeriodicalIF":1.4,"publicationDate":"2025-10-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12499680/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145239025","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Development and psychometric test of core competency assessment scale for gastrointestinal endoscopy nurses.","authors":"Guiqiong Xie, Zhi Zeng, Yazhi He, Xiang Liao, Chaoxiang You","doi":"10.1097/MD.0000000000044969","DOIUrl":"10.1097/MD.0000000000044969","url":null,"abstract":"<p><p>Digestive endoscopy nurses play a pivotal role in contemporary medical settings marked by advancing endoscopic technologies and increasing complexity. Nonetheless, there exists a deficiency in tools tailored for the effective evaluation of their essential competencies. Thus, there is an imperative to develop, validate, and evaluate the reliability and validity of a dedicated assessment scale for this purpose. Guided by role theory and core competency principles, we constructed a scale through literature analysis, semi-structured interviews, and expert consultations. An initial survey involving 413 digestive endoscopy nurses was conducted for item analysis and selection to refine the scale. Subsequently, the scale's reliability and validity were assessed through a second survey involving 512 nurses, ensuring its robustness and applicability in clinical settings. The developed Core Competency Assessment Scale for Digestive Endoscopy Nurses consists of 41 items organized into 5 dimensions: Professional Attitude, Theoretical Knowledge, Practical Skills, Communication and Coordination Abilities, and Professional Development. Each item demonstrates strong discriminative validity. The cumulative variance explained by these factors is 77.59%. The scale exhibits a Cronbach α coefficient of 0.84 and a test-retest reliability coefficient of 0.80. The content validity index at the item level ranges from 0.80 to 1, and at the scale level, it is 0.96. The Core Competency Assessment Scale for Digestive Endoscopy Nurses demonstrates robust reliability and validity, thereby establishing its suitability for evaluating their essential capabilities in clinical practice.</p>","PeriodicalId":18549,"journal":{"name":"Medicine","volume":"104 40","pages":"e44969"},"PeriodicalIF":1.4,"publicationDate":"2025-10-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12499667/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145239046","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Fostering sustainable infection prevention behaviors through organizational culture and psychological resources in healthcare settings.","authors":"Sun Ok Kim, Moon Suk Sim","doi":"10.1097/MD.0000000000045013","DOIUrl":"10.1097/MD.0000000000045013","url":null,"abstract":"<p><p>Infection prevention is a critical aspect of healthcare, directly impacting patient safety and outcomes. Previous studies have investigated various individual factors influencing infection control behaviors; however, limited research has examined the combined impact of organizational culture, environmental factors, and self-efficacy. This study aims to explore the multidimensional determinants of infection prevention behaviors using the information-motivation-behavioral skills framework. A cross-sectional study was conducted among 407 nurses from 2 mid-sized hospitals in South Korea. Data were collected using a structured survey assessing infection control organizational culture, prevention environment, knowledge, attitudes, job stress, self-efficacy, and prevention behaviors. Structural equation modeling was applied to analyze direct and indirect relationships between variables. Infection control organizational culture significantly influenced both infection control attitudes and prevention behaviors, while the prevention environment had a significant effect on job stress. Infection control self-efficacy emerged as a critical mediator, significantly enhancing prevention behaviors. Contrary to expectations, job stress did not directly undermine infection prevention behaviors but indirectly influenced them through self-efficacy. Knowledge had limited direct effects but influenced prevention behaviors through attitudes and self-efficacy. The findings underscore the importance of fostering a supportive organizational culture and prevention environment to enhance infection control practices. By integrating the Information-Motivation-Behavioral Skills Model framework, this study highlights the interconnected pathways influencing infection prevention behaviors. These insights can guide the development of targeted interventions and policies to improve healthcare safety and outcomes.</p>","PeriodicalId":18549,"journal":{"name":"Medicine","volume":"104 40","pages":"e45013"},"PeriodicalIF":1.4,"publicationDate":"2025-10-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12499678/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145239062","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Dissecting the causal association between perturbational responses of human blood cells and ischemic stroke: A Mendelian randomization analysis.","authors":"Bo Chen, Jiangfeng Chen, Zheqi Han, Xiaopan Huang, Liya Zhan","doi":"10.1097/MD.0000000000044976","DOIUrl":"10.1097/MD.0000000000044976","url":null,"abstract":"<p><p>This study explores the causal relationship between perturbational responses of human blood cells and ischemic stroke (IS) using Mendelian randomization (MR) analysis and assesses the potential impact of these blood cell perturbations on IS risk. We utilized human blood cell perturbation phenotype data from a large-scale genome-wide association study published in Nature Genetics (January 2024), involving over 4700 participants exposed to 36 perturbations from peripheral blood samples. Genetic determinants of IS were sourced from the IEU OpenGWAS database, encompassing data from 11,929 cases and 472,192 controls of European descent. The primary analytical approach employed was inverse variance weighting, supplemented by alternative methods including weighted median estimation, MR-Egger, simple model, and weighted model. These analyses were integrated with Benjamini-Hochberg false discovery rate (FDR) correction to evaluate the significance of causal associations. Our analysis identified a significant protective causal relationship between platelet perturbational response (odds ratio [OR] = 0.956, 95% confidence interval [CI] = 0.932-0.980, P < .001, PFDR = .036) and IS. Additionally, we found 2 potential causal factors: monocyte perturbational response (OR = 0.941, 95% CI = 0.893-0.991, P = .021, PFDR = .646), which is also protective, and eosinophil perturbational response (OR = 1.010, 95% CI = 1.001-1.018, P = .026, PFDR = .646), identified as a risk factor for IS. Additionally, reliability tests of this MR, including MR-Egger intercept and MR pleiotropy residual sum and outlier tests, revealed no evidence of pleiotropy, and Cochran Q test also confirmed the reliability of our results. Our findings highlight the platelet perturbational response as a significant protective factor against IS. In contrast, the eosinophil perturbational response indicated potential risk effects, while the monocyte perturbational response suggested protective effects; however, these associations did not remain significant after FDR correction. These insights lay the groundwork for future research focused on elucidating the underlying mechanisms and identifying potential therapeutic targets for stroke prevention and treatment.</p>","PeriodicalId":18549,"journal":{"name":"Medicine","volume":"104 40","pages":"e44976"},"PeriodicalIF":1.4,"publicationDate":"2025-10-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12499824/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145239065","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A bibliometric analysis of the effects of sex hormone profiles in women with polycystic ovary syndrome.","authors":"Bo Li, Shuang Li, Zibo Duan, Hui Yu, Yan Zhou, Xiaohua Lin","doi":"10.1097/MD.0000000000044965","DOIUrl":"10.1097/MD.0000000000044965","url":null,"abstract":"<p><strong>Background: </strong>Polycystic ovary syndrome (PCOS), a hormone-linked infertility disorder, severely impacts reproductive-aged women's health and societal well-being.</p><p><strong>Methods: </strong>Bibliometric analysis via Web of Science (2013-2023) using CiteSpace, VOSviewer, and Bibliometric.</p><p><strong>Results: </strong>Analyzed 1835 studies from 80 countries, led by China/US. Research surged post-2017. Journal of Gynecological Endocrinology was most productive; Fertility and Sterility had the highest impact. Key topics: insulin resistance, obesity, testosterone. Legro (prolific) and Azziz (highly cited) dominated authorship.</p><p><strong>Conclusion: </strong>PCOS-sex hormone research holds growing scientific/social relevance. Current hotspots focus on metabolic-pathological mechanisms, guiding future investigations into personalized therapies and risk management.</p>","PeriodicalId":18549,"journal":{"name":"Medicine","volume":"104 40","pages":"e44965"},"PeriodicalIF":1.4,"publicationDate":"2025-10-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12499726/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145239091","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}