Medicine最新文献

{"title":"Fat infiltration is moderately associated with disease activity in ankylosing spondylitis: a cross-sectional study: Lumbar paraspinal muscles in ankylosing spondylitis.","authors":"Murat Toprak, Nurşen Toprak","doi":"10.1097/MD.0000000000048558","DOIUrl":"10.1097/MD.0000000000048558","url":null,"abstract":"<p><p>To assess the association between lumbar paraspinal muscle (multifidus and erector spinae) and psoas muscle volume and fatty infiltration with clinical features in patients with ankylosing spondylitis (AS). This study included 35 patients with AS and 25 healthy controls (HC). Pain, disease activity, and functional status were assessed using the visual analog scale, Bath Ankylosing Spondylitis Disease Activity Index, and Bath Ankylosing Spondylitis Functional Index, respectively. Magnetic resonance imaging was used to compare cross-sectional area and fat infiltration at the L5/S1 level of the paraspinal muscles (multifidus, erector spinae) and psoas major muscles between the AS and healthy groups. The mean age of the patients included in the study was 31.54 ± 11.0 in the AS group and 29.04 ± 7.2 in the HC group (P > .05). The mean duration of disease in the AS group was 3.81 ± 2.8 years. There were no significant differences in age, body weight, height, or body mass index between the AS and HC groups. There was a significant positive correlation between fatty infiltration and disease duration (R = 0.4, P = .023) and Bath Ankylosing Spondylitis Functional Index scores (R = 0.3, P = .022). Increased fatty infiltration of lumbar paraspinal muscles is significantly associated with disease duration and functional disability in AS, indicating that muscle structural changes parallel clinical progression.</p>","PeriodicalId":18549,"journal":{"name":"Medicine","volume":"105 18","pages":"e48558"},"PeriodicalIF":1.4,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13138497/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147817322","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A young female with seropositive rheumatoid arthritis complicated by cavitary rheumatoid nodules in the lung: Case report.","authors":"Weiran Li, Sai Yuan, Xue Wu, Zhongping Wang, Jin Guo, Hao Yang, Mao Hua","doi":"10.1097/MD.0000000000048485","DOIUrl":"10.1097/MD.0000000000048485","url":null,"abstract":"<p><strong>Rationale: </strong>Rheumatoid arthritis (RA) is a systemic autoimmune disease characterized by inflammatory arthritis and extra-articular involvement, with lung involvement being the most common extra-articular manifestation. Rheumatoid nodules are highly specific for RA, occurring in 20% of patients and are more common in male patients with a history of smoking. This article aims to explore the diagnostic approach, key points of differential diagnosis, and treatment strategies of this disease by reporting the diagnosis and treatment process of a case of RA complicated with rheumatoid nodules in the lungs with cavity formation, and by reviewing the literature, providing diagnostic ideas for clinicians in treating similar cases.</p><p><strong>Patient concerns: </strong>The patient had a history of a persistent cough of unknown etiology, which persisted despite medical therapy. Additionally, the patient developed symmetric, progressive polyarticular pain, a key manifestation of the underlying disease.</p><p><strong>Diagnoses: </strong>This case was diagnosed as rheumatoid nodules in the lungs through a comprehensive analysis of the patient's clinical history (including RA and related symptoms), laboratory tests (elevated inflammatory markers and positive specific antibodies), chest CT imaging features (multiple nodules with cavities in both lungs), and pathological examination results (excluding tumors, tuberculosis and fungal infections, showing fibrinoid necrosis), and based on a multidisciplinary consultation.</p><p><strong>Interventions: </strong>The patient received comprehensive treatment including hormones and antirheumatic drugs to relieve symptoms and control the progression of RA.</p><p><strong>Outcomes: </strong>One year after discharge, the patient's pulmonary lesions gradually subsided and there was no disease progression.</p><p><strong>Lessons: </strong>For RA patients with positive serology, if multiple subpleural nodules or masses with cavities are found on chest CT, pulmonary rheumatoid nodules should be considered first. However, tuberculosis, fungal infection, tumor, and vasculitis must be systematically excluded. The pathology may be atypical, and the consistency of clinical, imaging and pathological findings and dynamic follow-up should be emphasized.</p>","PeriodicalId":18549,"journal":{"name":"Medicine","volume":"105 18","pages":"e48485"},"PeriodicalIF":1.4,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13138420/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147817427","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Analysis of the concurrent occurrence of medullary thyroid carcinoma and papillary thyroid carcinoma: A dual center, retrospective study in China.","authors":"Xiaogang Qi, Zhongkai Ni, Lihua Hong, Jinwang Ding, Tianhan Zhou","doi":"10.1097/MD.0000000000048580","DOIUrl":"10.1097/MD.0000000000048580","url":null,"abstract":"<p><p>This study examines the clinicopathological characteristics of patients with coexistent medullary thyroid carcinoma (MTC) and papillary thyroid carcinoma (PTC). A retrospective analysis was conducted on 169 patients who underwent surgical treatment for MTC at 2 medical centers between 2010 and 2019. The clinicopathological characteristics were documented, and associations between MTC/PTC and MTC were evaluated. Among the 169 MTC patients, 16 (9.5%) exhibited concomitant histological characteristics of both MTC and PTC. Three patterns of carcinoma distribution were identified: mixed carcinoma, tumors confined to the ipsilateral glandular lobe, and MTC/PTC lesions dispersed across both glandular lobes. Of these 16 patients, 9 were female and 7 were male, with a mean age of 50.6 years. The PTC lesions had a maximum diameter of 0.40 ± 0.21 cm, whereas the MTC lesions measured 1.73 ± 1.86 cm in maximum diameter. Additionally, 9 cases exhibited lymph node metastases, but no distant metastases were observed. Univariate analysis indicated no significant associations between MTC/PTC and MTC (P > .05), with no differences in survival or prognosis between the groups.</p>","PeriodicalId":18549,"journal":{"name":"Medicine","volume":"105 18","pages":"e48580"},"PeriodicalIF":1.4,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13138421/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147817430","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Advancements of artificial intelligence in Chinese herbal medicine recommendation: A comprehensive review of data-driven approaches and clinical applications form 2016 to 2025.","authors":"Meng Yang, Jing Jin, Ya-Li Liu, Long Zhao, Hui Chen, Wei-An Hao, Xin-Yi Ao, Zhi-Lin Ran, Zhi Li, Xin Zhou","doi":"10.1097/MD.0000000000048468","DOIUrl":"10.1097/MD.0000000000048468","url":null,"abstract":"<p><p>Chinese herbal medicine recommendations are a core part of personalized traditional Chinese medicine (TCM) diagnosis and treatment. However, the complexity of the multidimensional relationships in syndrome differentiation and treatment, herbal compatibility, and dosage selection poses significant challenges to clinical decision-making. Although artificial intelligence technology has made remarkable progress in TCM auxiliary diagnosis, a systematic review of Chinese herbal medicine recommendation methods remains lacking. This review aims to address this gap by systematically reviewing Chinese herbal medicine generation methods grounded in knowledge graph-based recommendations, deep learning-based recommendations, and hybrid model-based recommendations from 2016 to 2025. Major TCM databases that serve as foundational data sources, including traditional Chinese medicine systems, pharmacology database, and analysis platform, symptom mapping database, High-throughput Experimental and Reference Database, and Traditional Chinese Medicine Information Database, which are crucial for training these recommendation models. It further analyses their evolutionary technical patterns and clinical applicability, providing critical references for developing theoretically robust and clinically interpretable artificial intelligence models for TCM practice. Existing research focuses on constructing knowledge graph-driven Chinese herbal medicine recommendation models, which enhance the interpretability of recommendations by structuring the relationships among symptoms, Chinese herbal medicines, and diseases. Meanwhile, a clinical data-driven framework is introduced to discover potential patterns from real-world diagnosis and treatment scenarios. Deep learning-driven methods are adopted to achieve end-to-end feature learning for TCM knowledge reasoning. To improve the clinical applicability of Chinese herbal medicine recommendation models, a few studies have reported evaluation methods by experienced clinical doctors using herbal effectiveness and herbal compatibility scores to assess the reliability of the models and the accuracy of the recommendation results. Forming a comprehensive evaluation system may be the development trend of the evaluation system for clinical decision-support systems. This review outlines a theory-data-clinical ternary evaluation framework for Chinese herbal medicine recommendation models, providing a methodological innovation for developing intelligent systems that meet the standards of evidence-based medicine.</p>","PeriodicalId":18549,"journal":{"name":"Medicine","volume":"105 18","pages":"e48468"},"PeriodicalIF":1.4,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13138481/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147817440","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Meta-analysis of the skin redraping method and the Z-plasty method in the correction of epicanthus.","authors":"Mingxia Bai, Cheng Gong","doi":"10.1097/MD.0000000000048373","DOIUrl":"10.1097/MD.0000000000048373","url":null,"abstract":"<p><strong>Background: </strong>Epicanthus, a prevalent aesthetic concern in Asian populations, can be surgically corrected using various techniques. The skin redraping method and Z-plasty are 2 widely adopted approaches. This study aimed to conduct a systematic meta-analysis to comprehensively compare the clinical efficacy and outcomes of these 2 dominant surgical methods for epicanthus correction.</p><p><strong>Methods: </strong>A systematic literature search was performed across PubMed, Embase, China National Knowledge Infrastructure, Wanfang, and VIP databases from their inception through December 2025. Randomized controlled trials (RCTs) and cohort studies directly comparing skin redraping and Z-plasty for congenital epicanthus were eligible. Primary outcomes included postoperative change in intercanthal distance (ICD), scar assessment via the Vancouver Scar Scale at 6 months, patient satisfaction, recurrence rate, and incidence of complications. Study quality was assessed using the Cochrane Risk of Bias tool for RCTs and the Newcastle-Ottawa Scale for cohort studies. Statistical synthesis was performed using Review Manager 5.4 and R metafor package, employing fixed-effect or random-effects models based on heterogeneity (I2 statistic).</p><p><strong>Results: </strong>Fourteen studies (1539 patients) were included. All included studies were published in Chinese. Meta-analysis showed no significant difference in postoperative ICD reduction (mean difference = 0.56 mm, 95% confidence interval [CI]: -1.20 to 2.33, P = .53, I2 = 98%). Z-plasty yielded significantly better 6-month Vancouver Scar Scale scores (mean difference = 0.44, 95% CI: 0.31-0.57, P < .00001) and higher patient satisfaction (odds ratio [OR] = 0.39, 95% CI: 0.18-0.84, P = .02). Recurrence was significantly lower with Z-plasty (OR = 13.73, 95% CI: 2.53-74.49, P = .002), although this analysis was based on only 3 studies. Complication rates were similar (OR = 1.45, 95% CI: 0.65-3.23, P = .36).</p><p><strong>Conclusion: </strong>Both techniques effectively reduce ICD with comparable safety. Within the limited follow-up period of the included studies (up to 6 months), Z-plasty was associated with better scar appearance, higher satisfaction, and lower recurrence. The high heterogeneity and exclusive inclusion of Chinese studies necessitate cautious interpretation. Future multicenter RCTs with longer follow-up and standardized technique reporting are warranted.</p>","PeriodicalId":18549,"journal":{"name":"Medicine","volume":"105 18","pages":"e48373"},"PeriodicalIF":1.4,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13138403/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147817458","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Catheter-associated urinary tract infections in patients with gastric cancer after surgery: A retrospective study.","authors":"Jinlei Liu, Chunhai Zhang, Su Yan","doi":"10.1097/MD.0000000000048533","DOIUrl":"10.1097/MD.0000000000048533","url":null,"abstract":"<p><p>Perioperative catheterization is a well-known risk factor for developing postoperative catheter-associated urinary tract infection (CAUTI). The information about the effect of extended urinary catheterization after surgery for gastric cancer is still scarce. This is a retrospective study of 232 patients with gastric cancer who underwent surgery. Patients were divided into 2 groups based on the duration of their catheter placement: <72 hours and 72 hours or more. The primary outcome was CAUTI during the index hospitalization. Logistic regression was used to calculate odds ratios in unadjusted, adjusted, and sensitivity models. A dose-response analysis was conducted for ordered catheter duration categories. In patients with catheterization duration ≥72 hours versus those with catheterization <72 hours, CAUTI occurred significantly more frequently. In the unadjusted model, prolonged catheterization remained associated with increased odds of CAUTI, odds ratio = 5.66. The relationship was still significant, adjusting for age, diabetes, and operative time (longer operation time). After omitting patients with shock or severe complications, long-term catheterization was still independently associated with CAUTI, with an odds ratio of 3.99. A significant duration-related trend was observed with a steep increase in CAUTI after 72 hours of catheterization. Urinary catheterization for ≥72 hours was associated with an increased risk of CAUTI after gastric cancer surgery, which warrants the avoidance of unnecessary catheter prolongation if clinically possible.</p>","PeriodicalId":18549,"journal":{"name":"Medicine","volume":"105 18","pages":"e48533"},"PeriodicalIF":1.4,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13138448/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147816675","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Clinical outcome of pingyangmycin-polidocanol foam versus pingyangmycin alone in pediatric cystic lymphatic malformation with intracapsular hemorrhage: A retrospective cohort study.","authors":"Shuting Fang, Jiajie Cao, Gang Shen","doi":"10.1097/MD.0000000000048567","DOIUrl":"10.1097/MD.0000000000048567","url":null,"abstract":"<p><p>Cystic lymphatic malformations (CLMs) with intracapsular hemorrhage present a management challenge. This study aimed to describe and compare the clinical outcomes associated with pingyangmycin-polidocanol foam (PPF) versus pingyangmycin (PYM) sclerotherapy in this pediatric population. A retrospective cohort study was conducted on 74 pediatric patients with CLMs and intracapsular hemorrhage treated between October 2020 and May 2023. Patients were treated with either PPF (n = 37) or PYM (n = 37). The primary outcomes were lesion volume reduction grading, number of treatment sessions, pain relief, and family satisfaction. Secondary outcomes included adverse effects and recurrence. Factors associated with treatment response were explored. Baseline characteristics were comparable between groups. Children in the PPF group exhibited a greater median reduction in lesion volume after the first session (23.0 cm3 vs 12.2 cm3, P = .028) and received fewer median treatment sessions (2 vs 3, P = .023) compared with those in the PYM group. A higher proportion in the PPF group achieved a good response (Achauer grade III/IV) after the final treatment (83.8% vs 73.0%, P = .020) and reported complete pain relief (73.6% vs 41.7%, P = .036). Family satisfaction scores were significantly higher in the PPF group (P = .020). There were no significant differences in overall adverse event rates (18.9% vs 27.0%, P = .407) or recurrence rates (21.6% vs 27.0%, P = .787). Multivariable analysis confirmed that PPF treatment and macrocystic/mixed lesion type were independent factors associated with a good response. An increased number of treatment sessions was associated with more adverse effects but lower recurrence. In this retrospective analysis, PPF sclerotherapy was associated with a greater initial volume reduction, fewer treatment sessions, and higher family satisfaction compared with PYM alone in pediatric CLMs with intracapsular hemorrhage. Macrocystic and mixed lesions showed better response to PPF. Prospective studies are warranted to validate these findings.</p>","PeriodicalId":18549,"journal":{"name":"Medicine","volume":"105 18","pages":"e48567"},"PeriodicalIF":1.4,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13138432/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147817039","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Multiple linear regression analysis of factors affecting better-eye visual acuity in retinitis pigmentosa patients: A cross-sectional study.","authors":"Ling Xu, Guangzheng Dai, Yue Ren, Yan Sun, Shenming Hu, Yu Dang, Guanghao Qin, Wei He","doi":"10.1097/MD.0000000000048444","DOIUrl":"10.1097/MD.0000000000048444","url":null,"abstract":"<p><p>Retinitis pigmentosa (RP) is a progressive inherited retinal disorder that leads to severe visual impairment, even blindness. This condition significantly compromises quality of life and imposes substantial socioeconomic burdens. Currently, most cases of RP have no effective treatment, and therapies aimed at slowing the decline of patients' vision and improving their quality of life remain the main clinical tasks. Identifying key factors influencing visual outcomes is crucial for optimizing patient management. To bridge this gap, we conducted a study to explore these determinants. This study aimed to investigate the determinants of better-eye visual acuity in RP patients, focusing particularly on disease duration, age of onset, and a positive family history. In this cross-sectional study, 285 participants with clinically confirmed RP were enrolled. Comprehensive demographic and clinical data were collected, including a positive family history, age of onset, disease duration, and best-corrected visual acuity measuring in LogMAR units. Both simple and multiple linear regression analyses were employed to assess the associations between the clinical factors and visual outcomes. The study population had a mean age of onset of 13.61 ± 14.36 years and a mean disease duration of 26.36 ± 16.12 years, with 53.71% having a positive family history. Multiple linear regression analysis revealed that disease duration was significantly associated with lower visual acuity (β = 0.012, P < .001), while age of onset showed no significant association (β = -0.005, P = .149) after adjustment for all potential confounding factors. Based on these findings, disease duration emerges as a significant predictor of visual acuity in RP patients, highlighting its value as a prognostic indicator for clinical assessment. These findings underscore the importance of considering disease duration when developing personalized management strategies for RP patients. Further investigations to explore the underlying mechanisms linking disease duration and visual deterioration are warranted.</p>","PeriodicalId":18549,"journal":{"name":"Medicine","volume":"105 18","pages":"e48444"},"PeriodicalIF":1.4,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13138416/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147817041","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Predicting diagnostic gene biomarkers in allergic asthma.","authors":"Weihua Liu, Shuanglan Xu, Quan He","doi":"10.1097/MD.0000000000048466","DOIUrl":"10.1097/MD.0000000000048466","url":null,"abstract":"<p><strong>Background: </strong>Allergic asthma (AA) is a heterogeneous chronic inflammatory airway disorder. In this study, we performed a retrospective bioinformatics analysis based on public transcriptome datasets to identify critical genes associated with immune cell infiltration in AA and to establish a novel predictive model.</p><p><strong>Methods: </strong>Two transcriptome datasets (GSE73482 and GSE40889) were analyzed to explore key genes implicated in AA. Functional enrichment analyses, including Gene Ontology and Kyoto Encyclopedia of Genes and Genomes pathway analyses, were performed using Metascape. Least absolute shrinkage and selection operator regression was applied to screen feature genes and construct a diagnostic prediction model. Weighted gene co-expression network analysis (WGCNA) was conducted to identify AA-related gene modules. The fractions of infiltrating immune cells were estimated using single-sample gene set enrichment analysis (ssGSEA). Gene set variation analysis and gene set enrichment analysis (GSEA) were performed to explore the biological functions and related signaling pathways of the key genes. The Cistrome Data Browser database was used to predict transcription factors that potentially regulate these key genes.</p><p><strong>Results: </strong>We identified 4 highly significant genes in the brown module: membrane associated O acetyltransferase 1 (MBOAT1), leucine rich repeats and immunoglobulin-like domains 1 (LRIG1), LOC401357, and G protein regulated inducer of neurite outgrowth 3 (GPRIN3). GSEA results revealed that these key genes were significantly enriched in multiple immune-related signaling pathways. To further explore the regulatory network of these genes, transcription factors were predicted using the Cistrome Data Browser database, and the regulatory network was visualized using Cytoscape software.</p><p><strong>Conclusion: </strong>MBOAT1, LRIG1, LOC401357, and GPRIN3 are candidate AA-associated genes identified through retrospective modeling. The identification of these genes offers potential opportunities to utilize them as biomarkers and targets for immunotherapy in AA.</p>","PeriodicalId":18549,"journal":{"name":"Medicine","volume":"105 18","pages":"e48466"},"PeriodicalIF":1.4,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13138493/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147817164","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Relationship between plasma colloid osmotic pressure and 28-day all-cause mortality in ICU patients with sepsis: A retrospective study using the MIMIC-IV database.","authors":"Kailun Cai, Changqin Chen, Wenchao Mao, Xinle Lai, Changyun Zhao","doi":"10.1097/MD.0000000000048418","DOIUrl":"10.1097/MD.0000000000048418","url":null,"abstract":"<p><p>Plasma colloid osmotic pressure (PCOP) is crucial for regulating the exchange of fluids between the intravascular and extravascular compartments, as well as maintaining blood volume. PCOP has been noted in multiple studies to be involved in diseases linked to changes in vascular endothelial permeability. The study seeks to delve into the link between PCOP and clinical prognosis in critically ill patients with sepsis. Critically ill patients with sepsis, who required admission to the intensive care unit (ICU), were selected from the Medical Information Mart for Intensive Care IV database. The primary outcome of the study was all-cause mortality within 28 days. In total, 1651 ICU patients with sepsis were included. The average age was 65.86 ± 15.59 years. The 28-day all-cause mortality was 24.29%. Multivariate Cox proportional hazards regression analysis indicated that an increase in PCOP levels was associated to a decrease in all-cause mortality in the ICU (HR = 0.95, 95% confidence interval (CI): 0.92-0.98, P = .001) restricted cubic spline analysis demonstrated that when PCOP ≤ 16.258, an increase in PCOP was linked to a gradual decrease in 28-day all-cause mortality (HR = 0.88, 95% CI: 0.83-0.93, P < .001). PCOP is linked to 28-day all-cause mortality in ICU patients with sepsis. Within the cutoff value, sepsis patients with higher PCOP are associated with a lower risk of all-cause mortality within 28 days.</p>","PeriodicalId":18549,"journal":{"name":"Medicine","volume":"105 18","pages":"e48418"},"PeriodicalIF":1.4,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13138435/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147817243","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}