Medicine最新文献

{"title":"Integrative Korean medicine treatment without surgery for the management of subacute radiating pain attributed to vertebral artery loop formation: A case report and literature review.","authors":"Jung Min Yun, Dong Hyun Go, Sook-Hyun Lee","doi":"10.1097/MD.0000000000039483","DOIUrl":"10.1097/MD.0000000000039483","url":null,"abstract":"<p><strong>Rationale: </strong>Vertebral artery loop formation (VALF) compresses the adjacent cervical nerve root, resulting in cervical radiculopathy at the affected level. Neurosurgical interventions for anatomical separation are typically employed to relieve the symptoms, regardless of their duration. We herein report the management of the subacute symptoms of a rare case of cervical radiculopathy attributed to VALF using integrative Korean medicine (iKM) treatment without surgery.</p><p><strong>Patient concerns: </strong>A 54-year-old male patient presenting with a chief complaint of headache radiating to the posterior cervical and right scapular regions was treated with a 4-day program of inpatient care.</p><p><strong>Diagnoses: </strong>Based on the findings of the cervical spine magnetic resonance imaging, the patient was diagnosed with VALF on the right side at the C3/C4 level.</p><p><strong>Interventions: </strong>He underwent iKM treatment comprising acupuncture, pharmacopuncture, Chuna therapy, and herbal medicine.</p><p><strong>Outcomes: </strong>Significant improvement was noted in the patient's condition (neck pain Numeric Rating Scale scores of 5, 4, and 1; Neck Disability Index scores of 35.56, 20, and 4; and EuroQol 5-dimension index scores of 0.754, 0.787, and 0.862 at admission, discharge, and the 2-month follow-up, respectively; Patient Global Impression of Change scores of 3 and 1 at discharge and the 2-month follow-up, respectively).</p><p><strong>Lessons: </strong>This case report suggests that iKM treatment may be effective for subacute VALF symptoms without requiring surgery.</p>","PeriodicalId":18549,"journal":{"name":"Medicine","volume":"104 9","pages":"e39483"},"PeriodicalIF":1.3,"publicationDate":"2025-02-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11875575/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143527893","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Mining TCGA to reveal immunotherapy-related genes for soft tissue sarcoma.","authors":"Ruixin Li, Fan Yao, Yijin Liu, Xiaodan Wu, Peng Su, Tianran Li, Nan Wu","doi":"10.1097/MD.0000000000041392","DOIUrl":"10.1097/MD.0000000000041392","url":null,"abstract":"<p><p>Immunotherapy of soft tissue sarcoma is considered an important development direction for the future. Bioinformatics analysis of genetic changes in tumors and the immune microenvironment around tumors has proven to be a mature and reliable method for predicting tumor prognosis. By mining the Cancer Genome Atlas Program database, we found immunotherapy targets of soft tissue sarcoma and analyzed their biological behavior. The data of 265 samples were downloaded to analyze the expression profile of soft tissue sarcomas. This included calculating tumor purity through the estimation of stromal and immune cells in malignant tumors using expression data, acquisition of differential genes as prognostic factors, and enrichment analysis of the differential genes. Survival analysis showed longer overall survival times for patients with higher immune scores. We obtained 83 survival-related differential genes through survival analysis, and 23 genes that could be used as independent risk factors for the prognosis of soft tissue sarcoma were obtained by multiple regression analysis of the differential genes and other recognized risk factors. Gene set enrichment analysis of the differential genes obtained immune and inflammatory gene ontology terms and signal pathways, including regulation of the T-cell apoptotic process and leukocyte transendothelial migration. After validation in an independent data set of the Gene Expression Omnibus database, 12 genes were confirmed as a result. We believe that these differential genes will be new targets for sarcoma immunotherapy and key genes for the prognosis of soft tissue sarcoma.</p>","PeriodicalId":18549,"journal":{"name":"Medicine","volume":"104 9","pages":"e41392"},"PeriodicalIF":1.3,"publicationDate":"2025-02-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11875607/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143527921","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Retrospective analysis of admissions to the emergency department of an urban state hospital: A cross-sectional study of 5,279,630 patient visits (2019-2024).","authors":"Semih Eriten","doi":"10.1097/MD.0000000000041669","DOIUrl":"10.1097/MD.0000000000041669","url":null,"abstract":"<p><p>The study aims to comprehensively evaluate the demographic data, diagnostic spectrum, and temporal changes of 5.3 million patients in a state hospital emergency department in an urban area of Istanbul between 2019 and 2024. Data of 5,279,033 patients admitted to Sultanbeyli State Hospital Emergency Department between 2019 and 2024 were retrospectively analyzed. Sociodemographic characteristics, diagnoses, time of presentation, and seasonal variables of 879,839 average annual admissions (minimum: 653,746, maximum: 1068,504) were evaluated. Upper respiratory tract diseases accounted for 26.7% to 35.2% of the admissions during the period analyzed (P < .001). A remarkable increase in the prevalence of myalgia (2019: 5.01%, 2024: 10.29%; odds ratio: 2.17, 95% confidence interval: 1.98-2.37) was observed. In terms of age distribution, while the number of applicants aged 0 to 20 years was 493,382 (48.3%) in 2019, it decreased to 101,560 (15.5%) in 2024 (P < .001). Gender: female predominance was observed in all groups over 21 years of age (odds ratio: 1.43, 95% confidence interval: 1.35-1.52). During the pandemic period (2020-2021), the diagnosis of suspected disease increased to 24.42% and significant changes were observed in emergency department admission dynamics (annual coefficient of variation: 0.68, P < .001). This large-scale epidemiologic study reveals the presentation characteristics of an urban emergency department with an annual average of 880,000 visits. The data, especially the marked variation between age groups and changes in specific diagnostic categories, are of strategic importance for planning health services. Our findings provide an evidence-based basis for the organization of emergency health services in accordance with health needs.</p>","PeriodicalId":18549,"journal":{"name":"Medicine","volume":"104 9","pages":"e41669"},"PeriodicalIF":1.3,"publicationDate":"2025-02-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11875578/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143527958","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Study on the mechanism of Jiawei Shoutai Pill in the treatment of diminished ovarian reserve based on network pharmacology.","authors":"Xiaoyue Lyu, Chun Shen, Yumin Fang, Ying Zhao","doi":"10.1097/MD.0000000000041729","DOIUrl":"10.1097/MD.0000000000041729","url":null,"abstract":"<p><p>Jiawei Shoutai Pill is a traditional Chinese medicine formulation used clinically by physicians to treat diminished ovarian reserve (DOR) with positive outcomes. This study aimed to explore the potential pharmacological mechanisms of Jiawei Shoutai Pill in treating DOR by using network pharmacology methods. The effective compounds from traditional Chinese medicine were collected from the TCMSP, SYMmap, and PubChem, and the corresponding targets were retrieved from PubChem, Swiss Target Prediction, and DrugBank. Additionally, targets for DOR were obtained from GeneCards and Online Mendelian Inheritance in Man databases. Subsequently, multiple networks were constructed and gene enrichment analysis was performed using Cytoscape3.9.0 software. Molecular docking and molecular dynamics simulations were conducted based on previous research results. After screening, 72 active compounds and 292 target genes of Jiawei Shoutai Pill (excluding duplicate target genes) were identified, resulting in 1371 target genes related to the disease. A total of 149 cross-target genes were identified between the drug and disease targets. Kyoto encyclopedia of genes and genomes and gene ontology analyses emphasized the various gene functions and signaling pathways involved in treating DOR. Further molecular docking and dynamics simulations partially confirmed the practicality of the action Jiawei Shoutai Pill in vivo. The pharmacological effect of the Jiawei Shoutai Pill on DOR may be related to the PI3K-AKT, TNF, and lipopolysaccharide pathways. This study paves the way for further research on the mechanism of action of the Jiawei Shoutai Pill.</p>","PeriodicalId":18549,"journal":{"name":"Medicine","volume":"104 9","pages":"e41729"},"PeriodicalIF":1.3,"publicationDate":"2025-02-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11875589/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143527959","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The efficacy of Air Alert plyometric training program on enhancing biomotor skills in adolescent basketball players.","authors":"Onur Yalçin, Mahmut Açak, Ahmet Kurtoğlu, Özgür Eken, Ramazan Bayer, Monira I Aldhahi","doi":"10.1097/MD.0000000000041644","DOIUrl":"10.1097/MD.0000000000041644","url":null,"abstract":"<p><strong>Background: </strong>Basketball is an important sport that utilizes a variety of biomotor skills. Diverse training programs are employed to enhance the biomotor attributes and elevate the performance levels of basketball players. Plyometric training (PT) is frequently used to improve athlete performance. However, different models of PT can yield varying effects on athletic performance.</p><p><strong>Methods: </strong>This study aimed to determine the impact of a PT program named \"Air Alert\" on athletes' biomotor skills. Twenty-four basketball players aged 15 to 16 years voluntarily participated in the study. The participants were randomly assigned to 2 groups: the Air Alert plyometric training group (AIR) (n = 12) and the plyometric training group (n = 12). The AIR was trained 3 days a week, while the plyometric training group was trained 2 days a week for 15 weeks. Pre- and posttest measurements of height (cm), body weight (kg), vertical jump, line agility, 20 m sprint, Illinois agility, repeated sprint, and flamingo balance tests were performed for all participants.</p><p><strong>Results: </strong>There were no significant differences in height (cm) (F = 1.035, P = .320, ηp2 = .045), weight (F = 1.735, P = .201, ηp2 = .073), and BMI measurements (F = 1.376, P = .253, ηp2 = .059) within and between groups. However, significant differences were observed between the groups in vertical jump (F = 14.343, P = .001, ηp2 = .395), line agility (F = 75.366, P = .000, ηp2 = .774), 20 m sprint (F = 93.001, P = .000, ηp2 = .809), balance (F = 59.513, P = .000, ηp2 = .730), Illinois agility test (F = 143.243, P = .000, ηp2 = .867), and repeated sprint test (F = 140.986, P = .000, ηp2 = .865).</p><p><strong>Conclusion: </strong>The results of this study indicate that the AIR program is more effective in enhancing the biomotor skills of basketball players than other plyometric training programs. Based on these results, it is recommended that coaches who aim to develop training strategies to enhance athletic performance should consider incorporating an Air Alert program.</p>","PeriodicalId":18549,"journal":{"name":"Medicine","volume":"104 9","pages":"e41644"},"PeriodicalIF":1.3,"publicationDate":"2025-02-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11875624/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143527962","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Assessment of causal association between autoimmune thyroiditis and thyroid cancer: A Mendelian randomization study.","authors":"Qihong Zhang, Xiabin Lan","doi":"10.1097/MD.0000000000041633","DOIUrl":"10.1097/MD.0000000000041633","url":null,"abstract":"<p><p>Currently, the precise interplay between autoimmune thyroiditis, particularly Hashimoto thyroiditis, and thyroid cancer remains ambiguous. While certain observational studies suggest autoimmune thyroiditis (including Hashimoto thyroiditis) as a predisposing factor for thyroid cancer. Nevertheless, it is still uncertain whether autoimmune thyroiditis is independently associated with thyroid cancer. We employed Mendelian randomization (MR) study methodology, a genetic analysis approach, to evaluate the causal impact of autoimmune thyroiditis on the occurrence of thyroid cancer. We obtained and synthesized statistical data by utilizing public available genome-wide association studies (GWAS). Our study utilized GWAS summary statistics datasets associated with autoimmune thyroiditis (including Hashimoto thyroiditis) as the exposure data source and selected GWAS summary statistics datasets related to thyroid cancer as the outcome data source. Single nucleotide polymorphisms closely associated with autoimmune thyroiditis were chosen as instrumental variables. We conducted 2-sample MR analyses to elucidate the causal association between autoimmune thyroiditis and thyroid cancer. The inverse variance-weighted (IVW) method was employed as the primary methodology, supplemented by additional MR methods including MR-Egger regression, weighted median, simple mode, and weighted mode analyses, to bolster the robustness of our findings. The MR analysis conducted using the IVW method did not confirm a causal relationship between autoimmune thyroiditis and thyroid cancer (odds ratio [OR] = 0.8554, 95% confidence interval [CI]: 0.7193 to 1.0172, P = .0772; OR = 0.8477, 95% CI: 0.7159 to 1.0039, P = .0555; and OR = 1.1324, 95% CI: 0.9342 to 1.3725, P = .2052, from 3 eligible dataset analyses, respectively). Additionally, MR analysis did not observe a causal association between Hashimoto thyroiditis and thyroid cancer (OR = 1.0449, 95% CI: 0.9400 to 1.1615, P = .4155; and OR = 0.9897, 95% CI: 0.8174 to 1.1984, P = .9159, from 2 eligible dataset analyses, respectively). Consistency in results across alternative MR methods was observed. This study employing MR methodology indicates the absence of significant causal relationship between exposure to autoimmune thyroiditis (including Hashimoto thyroiditis) and thyroid cancer. Further validation through larger-scale studies with increased sample sizes is warranted in future investigations.</p>","PeriodicalId":18549,"journal":{"name":"Medicine","volume":"104 9","pages":"e41633"},"PeriodicalIF":1.3,"publicationDate":"2025-02-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11875592/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143527776","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Circulating cytokines levels and the risk of polycystic ovary syndrome: A Mendelian randomization analysis.","authors":"Yumin Jiang, Yunqing Li, Yuhua Huang","doi":"10.1097/MD.0000000000041359","DOIUrl":"10.1097/MD.0000000000041359","url":null,"abstract":"<p><p>This study utilized Mendelian randomization (MR) analysis to explore the causal relationship between circulating cytokines and polycystic ovary syndrome (PCOS), and to identify potential biomarkers of PCOS mechanisms. Genetic instrumental variables for cytokines were derived from 2 large-scale genome-wide association studies (GWAS) involving 8293 and 14,824 European participants. Summary statistics from a GWAS meta-analysis (10,074 PCOS cases and 103,164 controls of European ancestry) were used in the discovery phase of MR analysis. Replication analysis utilized another GWAS meta-analysis dataset (3609 cases and 229,788 controls). The primary analysis employed the inverse-variance weighted (IVW) method, with secondary methods including constrained maximum likelihood model averaging, weighted median, and weighted mode. Meta-analysis was combined with MR results, while heterogeneity and horizontal pleiotropy were assessed using leave-one-out, MR-Egger intercept test, and Mendelian Randomization Pleiotropy Residual Sum and Outlier. Sensitivity analysis confirmed the robustness of the results. Reverse MR analysis was used to explore the association of PCOS with the identified cytokines. Meta-analysis revealed that increased CCL4 (C-C motif chemokine 4) levels were associated with a higher risk of PCOS (odds ratio [OR] = 1.123, 95% confidence interval [CI]: 1.056-1.195; P < .001). Decreased PCOS risk was linked to CXCL11 (C-X-C motif chemokine 11, OR = 0.930, 95% CI: 0.890-0.970; IVW-false discovery rate [FDR] P = 4.85 × 10-4) and CD6 (T-cell surface glycoprotein CD6 isoform, OR = 0.730, 95% CI: 0.890-0.970; IVW-FDR P = .008). Sensitivity analysis confirmed the robustness of the findings. MR analysis suggests a potential causal link between alterations in CCL4, CXCL11, CD6, and PCOS risk, highlighting the role of cytokines in PCOS development and progression, warranting further investigation.</p>","PeriodicalId":18549,"journal":{"name":"Medicine","volume":"104 9","pages":"e41359"},"PeriodicalIF":1.3,"publicationDate":"2025-02-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11875618/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143527784","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Depression and substance abuse among university students.","authors":"Kefie Manaye Mengistie, Kelemu Zelalem Berhanu","doi":"10.1097/MD.0000000000041671","DOIUrl":"10.1097/MD.0000000000041671","url":null,"abstract":"<p><p>The purpose of the study was to examine the association between depression and substance abuse and to assess their prevalence and associated factors. A cross-sectional design was employed. To collect data for the present study, 2 scales (Beck depression inventory and Alcohol, Smoking, and Substance Involvement screening Test [ASSIST]) was administered to students. Two hundred fifty seven Addis Ababa Institute of Technology final year regular undergraduate students were participated. The results revealed that a high correlation was found between depression and substance abuse. The prevalence of depression is 27.2%. Similarly, the prevalence of alcohol abuse, khat abuse, cigarette abuse and cannabis abuse are 25.5%, 17.7%, 9.5%, and 3.3% respectively. Hence, the overall substance abuse prevalence is 14%. Alcohol is most abused drug followed by khat abuse. Cigarette and cannabis abuse take the 3rd and 4th rank respectively. Multivariate test of significance reveals that gender, religion and the interaction of gender with religion, residence, and ethnicity had an effect on the two combined dependent measures. Females are more depressed than males. In turn, males are more substance abusers than females. The researchers suggested that the university to establish its own substance abuse prevention and treatment working center which is open for psychologists, therapist and other health workers.</p>","PeriodicalId":18549,"journal":{"name":"Medicine","volume":"104 9","pages":"e41671"},"PeriodicalIF":1.3,"publicationDate":"2025-02-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11875610/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143527792","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Diagnostic accuracy of the Geneva clinical scale for diagnostic prediction of pulmonary embolism in adults aged 18 and older admitted between 2009 and 2020 with suspected pulmonary embolism at a Third-Level Institution in Colombia: A retrospective cohort study.","authors":"Cristian López-Vega, Michel Pérez-Garzón, Leonora Ortiz-García-Herreros, Alirio Bastidas-Goyes, Manuel Aramendiz-Narvaez, Estefan Ramos-Isaza, Henry Robayo-Amortegui","doi":"10.1097/MD.0000000000041603","DOIUrl":"10.1097/MD.0000000000041603","url":null,"abstract":"<p><p>To assess the overall applicability of the Geneva scale for diagnosing pulmonary embolism in adults aged 18 and older. A retrospective cohort study with diagnostic test analysis was conducted on patients in the emergency department or hospitalized between 2009 and 2020 with suspected pulmonary embolism at a Third-Level Institution in Colombia. Local study. The original and simplified Geneva scores were applied to 1237 subjects aged 18 and older with suspected pulmonary embolism and compared with confirmatory results from pulmonary angiography. All necessary variables for constructing the original and simplified Geneva rules were recorded, and calculations for sensitivity (S), specificity (E), likelihood ratios, and receiver operating characteristic curves were performed. The Geneva original score exhibited an S, E, positive likelihood ratio, negative likelihood ratio, and area under the curve of 60%, 54%, 1.3, 0.728, and 0.506, respectively. The simplified Geneva score showed 59%, 57%, 1.4, 0.7, and 0.546 for S, E, positive likelihood ratio, negative likelihood ratio, and area under the curve, respectively. The use of the original or simplified Geneva score in our population may not be useful for a diagnostic approach to pulmonary embolism. Both scales demonstrate almost negligible discriminatory capacity, necessitating the evaluation of other standardized clinical decision rules to assess the diagnosis and pretest probability of pulmonary thromboembolism.</p>","PeriodicalId":18549,"journal":{"name":"Medicine","volume":"104 9","pages":"e41603"},"PeriodicalIF":1.3,"publicationDate":"2025-02-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11875587/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143527800","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Examination of factors causing postoperative pneumonia in elderly hip fracture patients: A narrative review.","authors":"Dongqi Ji, Huanhuan Li, Shasha Jin, Chunyan Tian, Liang Wu","doi":"10.1097/MD.0000000000041700","DOIUrl":"10.1097/MD.0000000000041700","url":null,"abstract":"<p><p>With the increasing aging problem, the number of fractures in the elderly is also increasing, of which hip fractures are more common, known as \"the last fracture of life.\" Postoperative pneumonia (POP) is a common complication of hip fracture, which greatly increases the mortality of patients. It is particularly important to clarify the factors of perioperative pneumonia for the prevention and treatment process. In this paper, the factors causing POP mainly include demographic factors, pre-injury comorbidities, blood index parameters, major clinical interventions and related mechanisms were reviewed, and the risk degree of the factors causing postoperative pneumonia was mainly discussed, and they were divided into independent factors and risk factors. The objective is to make the most accurate POP prevention measures for hip fracture patients according to the classification of independent factors and risk factors, and reduce the incidence of postoperative pneumonia.</p>","PeriodicalId":18549,"journal":{"name":"Medicine","volume":"104 9","pages":"e41700"},"PeriodicalIF":1.3,"publicationDate":"2025-02-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11875577/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143527832","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}