Medicine最新文献

{"title":"Analysis of hydrogen sulfide-related signatures of breast cancer identified 2 distinct subtypes: Implications for individualized therapeutics.","authors":"Congyan Yu, Yong Shen, Xuen Li","doi":"10.1097/MD.0000000000042076","DOIUrl":"10.1097/MD.0000000000042076","url":null,"abstract":"<p><p>Hydrogen sulfide (H2S) is a vital gasotransmitter involved in breast cancer (BC) pathogenesis. This study aims to employ hydrogen sulfide-related genes (HSRGs) for molecular classification of BC and, accordingly, to establish a robust prognostic risk signature. Transcriptomic, clinical, and mutational data of BC patients were collected from the cancer genome atlas and gene expression omnibus databases. Prognostic relevance was evaluated using Cox regression analysis, while consensus clustering analysis was employed for molecular subtyping. Gene expression profiles, prognosis, immune infiltration patterns, drug sensitivity, and response to immunotherapy were compared between subtypes. Multiple-gene prognostic features were developed and assessed along with a nomogram. The gene expression was validated in clinical samples using quantitative polymerase chain reaction. Among 282 HSRGs, 46 exhibited significant correlations with BC prognosis. Consensus clustering identified 2 distinct molecular subtypes (C1 and C2). C1 displayed significantly improved prognosis compared to C2, accompanied by increased infiltration of B cells, T cells, monocytes, and mast cells but decreased macrophage infiltration. Moreover, C1 demonstrated higher drug sensitivity and immunotherapeutic response relative to C2. Enrichment analysis revealed suppressed immune-related processes and pathways in C2 while cell cycle regulation and chromosomal processes were significantly activated. Additionally, a risk feature comprising 6 differentially expressed genes between subtypes was constructed; this feature performed well in prognostic prediction. Integration of this feature with other clinical parameters (radiotherapy/chemotherapy status, clinical stage, N stage) into a nomogram further enhanced prognostic accuracy. Clinical samples further validated the high expression of ATP13A5, LRTM2, MAFA, and SPDYC and the low expression of CYP4F12 and TNN in BC. Our findings highlight the clinical relevance of HSRGs in BC, providing a basis for precise molecular classification and prognosis evaluation. The developed risk feature and nomogram offer practical tools for guiding personalized treatment strategies in clinical practice.</p>","PeriodicalId":18549,"journal":{"name":"Medicine","volume":"104 14","pages":"e42076"},"PeriodicalIF":1.3,"publicationDate":"2025-04-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143803795","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The lamina-spinous process-ligament complex implantation for the spinal stability: A case report and review of literature.","authors":"Tao Lu, Huichun Yuan, Xueqin Hu, Wuyang Cao, Zeng Yang, Zhiwei Zhou, Haibin Leng, Nianhua Wang, Lixin Xu","doi":"10.1097/MD.0000000000042044","DOIUrl":"10.1097/MD.0000000000042044","url":null,"abstract":"<p><strong>Rationale: </strong>The posterior cervicothoracic fusion is a common surgical skill for the treatment of spinal diseases. Since postoperative complications contribute to compressive neurological symptoms, this case is reported to provide a surgical option for the preservation of spine stability and bone fusion.</p><p><strong>Patient concerns: </strong>A 36-year-old male presented numbness of both lower limbs for more than half a year, accompanied by unstable walking for more than 2 months.</p><p><strong>Diagnoses: </strong>Clinical examination revealed grade 4 muscle strength of both lower extremities, low muscle tension, loss of abdominal wall reflex, cremasteric reflex and anal reflex, and unsteady gait. Magnetic resonance imaging suggested a 5th cervical vertebrae-2nd thoracic vertebrae (C5-T2) intramedullary space-occupying mass.</p><p><strong>Interventions: </strong>Written informed consent was obtained from the patient before surgery. To relieve his symptom and preserve spine stability, we performed an operation to remove the C5-T2 intramedullary ependymoma. Meantime, the laminae-spinous process complex was replanted and fixed in situ.</p><p><strong>Outcomes: </strong>Magnetic resonance imaging indicated that the tumor was completely resected. There are no delayed bleeding and instances of implant loosening. There were no tumor recurrence, spinal stenosis, spinal instability, and spondylolisthesis, and part of vertebral laminae have formed bony healing.</p><p><strong>Lessons: </strong>Our case suggests that the in situ preservation of supraspinous ligament longitudinal continuity of lamina-spinous process-ligament complex implantation skill will provide a surgical option for the preservation of spine stability and bone fusion in patients with long-segment intraspinal tumors.</p>","PeriodicalId":18549,"journal":{"name":"Medicine","volume":"104 14","pages":"e42044"},"PeriodicalIF":1.3,"publicationDate":"2025-04-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143803880","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Uncovering non-autoimmune hypothyroidism: A case report of rhabdomyolysis and myocarditis mimicking acute coronary syndrome.","authors":"Hyejin Jeon, Seunghye Lee, Sehyun Jung, Hani Jang, Se-Ho Chang, Hyun-Jung Kim","doi":"10.1097/MD.0000000000042047","DOIUrl":"10.1097/MD.0000000000042047","url":null,"abstract":"<p><strong>Rationale: </strong>Non-autoimmune hypothyroidism is a rare but significant cause of rhabdomyolysis and myocarditis, which can mimic acute coronary syndrome. Early recognition and treatment of hypothyroidism are crucial, especially in patients with chronic kidney disease (CKD), where delayed diagnosis may lead to life-threatening complications such as acute kidney injury.</p><p><strong>Patient concerns: </strong>A 71-year-old male with diabetes, CKD stage G3aA3, and a history of chronic myelogenous leukemia presented with myalgia, anorexia, and anuria. He also reported intermittent chest pain for 1 month, progressing to severe symptoms including decreased urine output and anuria.</p><p><strong>Diagnoses: </strong>Laboratory findings revealed acute kidney injury (serum creatinine: 12.14 mg/dL), extreme elevations in muscle enzymes (creatine kinase: 250,000 IU/L), and cardiac biomarkers (troponin-T: 543 ng/L). Initial management did not improve his condition. On day 15, thyroid function tests confirmed non-autoimmune hypothyroidism (TSH: 55.58 μIU/mL, free T4: 0.06 ng/dL).</p><p><strong>Interventions: </strong>The patient underwent hemodialysis and conservative treatment initially, followed by levothyroxine replacement therapy on day 16.</p><p><strong>Outcomes: </strong>Renal function, urine output, and muscle enzyme levels gradually improved after thyroid hormone supplementation. By discharge on day 40, the patient's serum creatinine decreased to 3.08 mg/dL, and hemodialysis was discontinued. At 7 months posttreatment, his renal function stabilized at CKD stage G3bA2 with normal thyroid function.</p><p><strong>Lessons: </strong>This case highlights the importance of considering hypothyroidism in patients with unexplained rhabdomyolysis and persistent cardiac symptoms, particularly in those with CKD. Early thyroid function testing can lead to timely treatment and improved outcomes in such complex cases.</p>","PeriodicalId":18549,"journal":{"name":"Medicine","volume":"104 14","pages":"e42047"},"PeriodicalIF":1.3,"publicationDate":"2025-04-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143803427","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evaluation of pharmacogenomic testing to identify cytochrome P450 and SLCO1B1 enzymes and adverse drug events: A non-experimental observational research.","authors":"Tiffany Flowers-Moore, Alexandra R Rapp, Jose H Salazar, Rajkumar Rajendran","doi":"10.1097/MD.0000000000042031","DOIUrl":"10.1097/MD.0000000000042031","url":null,"abstract":"<p><p>A laboratory-initiated preemptive and reactive cytochrome P450 and SLCO1B1 PGx testing protocol was evaluated in a private toxicology laboratory with the intent of identifying enzyme frequencies and associated adverse drug events. This study involved non-experimental observational research. During the retrospective medical chart review, patient demographics, statements of medical necessity, and PGx testing data were collected. Frequencies and percentages were calculated for the collected data, and statistical analysis was performed using Intellectus online software. A total of 192 PGx patient records from September 2019 to October 2021 were retrospectively reviewed. For patient demographics, men (n = 118; (61%)) were the majority gender identified among the patient population and Caucasians (n = 112; (58%)) followed by African Americans (n = 37; (19%)) were the most identified ancestry. The mean age of the patients was 69 (±9) years. CYP1A2 hyperinducers, followed by CYP3A5 poor metabolizers and CYP2B6 intermediate metabolizers, are the most encountered cytochrome P450 and SLCO1B1 enzymes. Regarding drug-gene interactions, 41 patients had 1 interaction, 29 had 2, and 31 had 3 or more interactions. For drug-drug interactions, 35 patients had 1 interaction, 15 had 2, and 30 had 3 or more interactions. Overall, 123 patients showed a minor or greater impact on drug-drug or drug-gene interactions. Overall, our study identified cytochrome P450 and SCLCO1B1 enzyme frequencies and patients experiencing actionable adverse drug events. By raising awareness of PGx test results through individualized clinician training, education, and interventions, these adverse events can be promptly identified and resolved.</p>","PeriodicalId":18549,"journal":{"name":"Medicine","volume":"104 14","pages":"e42031"},"PeriodicalIF":1.3,"publicationDate":"2025-04-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143803436","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Relationship between elevated homocysteine levels and the degree of white matter lesions in stroke patients.","authors":"Xingying Wu, Yanni Du, Na Wei, Leiqiang Pan, Chuanyu Cao","doi":"10.1097/MD.0000000000041984","DOIUrl":"10.1097/MD.0000000000041984","url":null,"abstract":"<p><p>This study explores the relationship between elevated homocysteine (Hcy) levels and white matter lesion (WML) severity in stroke patients, aiming to clarify Hcy role in stroke pathology and support clinical treatment and prevention strategies for cerebrovascular diseases. A retrospective analysis was conducted on 200 stroke patients from Guyuan People's Hospital (2022-2024). Hcy levels were measured using a Beckman AU5800 analyzer, and WML severity was assessed via magnetic resonance imaging using the Fazekas scale. Carotid intima-media thickness (cIMT) was measured by ultrasound. The mean Hcy level was significantly higher in the moderate to severe WML group (16.2 ± 5.3 μmol/L) compared to the mild group (11.4 ± 3.8 μmol/L, P < .001), showing a positive correlation with WML severity. The moderate to severe group also had significantly higher left and right cIMT (P < .001). Logistic regression identified age, hypertension, diabetes, Hcy levels, and right-sided cIMT as independent predictors of moderate to severe WML. Receiver operating characteristic curve analysis indicated high diagnostic value for both Hcy levels and right-sided cIMT, with combined use improving assessment accuracy. Elevated Hcy levels and increased right-sided cIMT are independent risk factors for moderate to severe WML in stroke patients. Combining these measures improves assessment accuracy and highlights the need for targeted interventions. Future research should investigate Hcy and cIMT mechanisms and interventions to enhance clinical application.</p>","PeriodicalId":18549,"journal":{"name":"Medicine","volume":"104 14","pages":"e41984"},"PeriodicalIF":1.3,"publicationDate":"2025-04-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143803748","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Research progress on acupuncture intervention for cervical spondylotic radiculopathy with Qi stagnation and blood stasis syndrome: A review.","authors":"Furong Xue, Weiguo Liu","doi":"10.1097/MD.0000000000041837","DOIUrl":"10.1097/MD.0000000000041837","url":null,"abstract":"<p><p>With improvements in living standards and lifestyle changes, the prevalence of cervical spondylotic radiculopathy (CSR) has significantly risen, severely impacting patients' quality of life. Currently, Western medicine primarily treats CSR with oral medications and surgical interventions. However, the condition often recurs, with a high risk of side effects, failing to provide a fundamental cure. As research in traditional Chinese medicine (TCM) on this condition deepens, acupuncture has made significant progress, demonstrating notable clinical efficacy. Acupuncture has been shown to be highly effective in treating radiculopathy associated with cervical spondylopathy, characterized by its simple procedure, high safety, and diverse treatment methods, and has gained widespread recognition. This paper reviews the clinical research literature on acupuncture for CSR, summarizing acupuncture interventions and related therapies from 4 perspectives: simple acupuncture therapy, combined acupuncture and external therapy, and pathogenesis mechanisms, thereby providing a reference for the clinical treatment of CSR.</p>","PeriodicalId":18549,"journal":{"name":"Medicine","volume":"104 14","pages":"e41837"},"PeriodicalIF":1.3,"publicationDate":"2025-04-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143803755","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"An antibody-dependent cellular phagocytosis-related gene signature predicts survival and response to immunotherapy in stomach adenocarcinoma.","authors":"Xiaochuan Li, Hongjian Wang, Xiaofeng Li, Miaoen Zeng, Zhuguang He, Linjie Song, Zhiming Chen, Xinyue Tang, Ang Wang","doi":"10.1097/MD.0000000000042079","DOIUrl":"10.1097/MD.0000000000042079","url":null,"abstract":"<p><p>Antibody-dependent cellular phagocytosis (ADCP) is an immune biological process and plays a biological role in the clearance of tumor cells and the response to immune checkpoint inhibitors. However, the effects of ADCP on stomach adenocarcinoma (STAD) remain unclear. Clinical and genomic data were extracted from multiple datasets. The ADCP-related signature was established using Cox least absolute shrinkage and selection operator regression. Expression of the C5a receptor also known as complement component 5a receptor 1 in the tumor and adjacent-normal tissues was calculated using immunohistochemistry staining. Validation of the signature was conducted in the training and validation cohorts by Cox regression and log-rank tests. Furthermore, the immune infiltrates, the tumor immune dysfunction and exclusion score, and tumor mutation burden score were calculated using the corresponding algorithms, and Mann-Whitney U tests were used to evaluate the differences between groups. Seventy-three hub genes with predictive performance were identified to establish an ADCP-related signature. Accordingly, a 27-gene signature was established, C5a receptor also known as complement component 5a receptor 1, one of the signature genes, had higher expression in tumors than adjacent-normal samples, and its predictive performance was validated in the GSE84437 and The Cancer Genome Atlas cohorts. We found that the ADCP-related signature is an excellent prognostic predictor of STAD. Moreover, the molecular characteristics and some indices of response to immunotherapy differed between the high- and low-risk groups. We constructed a 27-gene signature that is associated with the prognosis and response to STAD-based immunotherapy and provide insights into the biological mechanisms underlying this predictive function.</p>","PeriodicalId":18549,"journal":{"name":"Medicine","volume":"104 14","pages":"e42079"},"PeriodicalIF":1.3,"publicationDate":"2025-04-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143803793","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Causal association of blood metabolites, immune cells, and lung cancer: A mediation Mendelian randomization study.","authors":"Tonglin Sun, Sheng Chen, Zhengyi Liu, Yuxiang Hu, Yinhui Sun, Lihuai Wang","doi":"10.1097/MD.0000000000042053","DOIUrl":"10.1097/MD.0000000000042053","url":null,"abstract":"<p><p>Lung cancer ranks highest in annual mortality among all cancers, and blood metabolites may influence its onset and progression. Our objective is to assess the causal relationships between blood metabolites and both non-small cell lung cancer (NSCLC) and small cell lung cancer (SCLC), while exploring the mediating effects of immune cells. We utilized publicly available genetic data to investigate the potential causal relationships between blood metabolites and NSCLC as well as SCLC using a 2-sample Mendelian randomization (MR) approach. In our primary analysis, we employed the inverse variance weighted (IVW) method and conducted sensitivity analyses and Steiger test to assess the reliability and directionality of the causal relationships. Additionally, we employed a 2-step MR approach to evaluate the mediating role of immune cells in these causal relationships. The IVW method revealed that palmitoylcarnitine levels (metabolon platform) and 4 other blood metabolites are risk factors for NSCLC, while tetrahydrocortisol glucuronide levels and 2 other blood metabolites are protective factors for NSCLC. Additionally, Alpha-hydroxyisovalerate levels and 8 other blood metabolites are risk factors for SCLC, whereas dimethylglycine levels and 3 other blood metabolites are protective factors for SCLC. Furthermore, IgD- CD27- B cell %B cell, CD27 on IgD- CD38dim B cell, and CD3 on Naive CD4+ T cell mediate some of the relationships between blood metabolites and NSCLC. Activated and secreting CD4 regulatory T cell %CD4+ T cell, CD14- CD16- Absolute Count, and IgD on IgD+ CD24+ B cell mediate some of the relationships between blood metabolites and SCLC. There are significant causal relationships between blood metabolites and both NSCLC and SCLC, with some of these relationships mediated by immune cells. This aids us in influencing the role of blood metabolites in lung cancer by intervening with immune cells, thereby providing more avenues for the prevention and treatment of lung cancer.</p>","PeriodicalId":18549,"journal":{"name":"Medicine","volume":"104 14","pages":"e42053"},"PeriodicalIF":1.3,"publicationDate":"2025-04-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143803873","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Mendelian randomization analysis of the causal relationship between plasma proteins and childhood asthma.","authors":"Caiwen Wang, Hui Fan, Yingying Sun, Liping Sun","doi":"10.1097/MD.0000000000042050","DOIUrl":"10.1097/MD.0000000000042050","url":null,"abstract":"<p><p>Existing studies have suggested a significant association between plasma proteins and childhood asthma, but the specific causal relationship between them remains unclear. Therefore, we aimed to evaluate the causal relationship between plasma proteins and childhood asthma using Mendelian randomization (MR) methods. We conducted a 2-sample MR analysis and a reverse MR analysis. The GWAS summary statistics for plasma proteins were derived from a European population, covering a total of 4907 plasma proteins. The GWAS summary statistics for childhood asthma were obtained from the FinnGen database, including 3025 childhood asthma patients and 135,449 normal controls. Five MR methods, which include inverse-variance weighted, weighted median, MR-Egger, weighted mode, and simple mode, were utilized to investigate the causal relationship between plasma proteins and childhood asthma. The results indicated that ITIH4 is a risk factor for childhood asthma, while THSD1, AMIGO2, L1CAM, MICB, and SELE are protective factors. Leave-one-out analysis, heterogeneity tests, and pleiotropy tests confirmed the reliability and robustness of our findings. Additionally, reverse MR analysis showed no significant causal relationship between childhood asthma and ITIH4, THSD1, AMIGO2, L1CAM, MICB, and SELE. Our study used MR methods to confirm the specific causal relationships between 4907 plasma proteins and childhood asthma. Specifically, ITIH4 was likely to be significantly associated with an increased risk of childhood asthma, while THSD1, AMIGO2, L1CAM, MICB, and SELE were likely to be significantly associated with a reduced risk of childhood asthma.</p>","PeriodicalId":18549,"journal":{"name":"Medicine","volume":"104 14","pages":"e42050"},"PeriodicalIF":1.3,"publicationDate":"2025-04-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143803696","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The study of total hip arthroplasty outcomes among statin users in Sina Hospital, Iran.","authors":"Erfan Barootchi, Sina Arefi, Pardis Zamani, Mohammad Soleimani, Amir Hossein Karimi, Reza Hajebi, Seyyed Hossein Shafiei","doi":"10.1097/MD.0000000000042074","DOIUrl":"10.1097/MD.0000000000042074","url":null,"abstract":"<p><p>Total hip arthroplasty (THA) is a highly effective intervention for hip osteoarthritis. The increasing demand for THA is driven by an expanding pool of eligible patients, including elderly individuals with comorbidities. Statins, which are widely used to reduce cardiovascular risk, have shown potential benefits in reducing postoperative complications after joint arthroplasty. This study aims to evaluate the influence of statin use on THA outcomes and postoperative quality of life (QOL). This retrospective observational cohort study was conducted at a single center. Patients who underwent primary THA between 2015 and 2021 were identified and categorized into the statin-exposed and non-statin cohorts. Patients were interviewed regarding postoperative complications and completed the Short Form-8 questionnaire to assess their QOL. Statistical analyses were performed using t tests, Chi-square tests, and correlation tests. In total, 364 patients were included in the final sample with 37 patients in the statin-exposed cohort. The statin-exposed cohort included significantly older patients with higher comorbidity rates. However, there were no significant differences in postoperative joint or systemic complications or readmission rates between the 2 cohorts. The in-hospital mortality was lower in the statin cohort, but the difference was not statistically significant (0% vs 8.9%, P = .059). There was no significant difference between the 2 cohorts based on the Short Form-8 questionnaire (21.65 ± 8.14 vs 20.16 ± 8.67, P = .310). Contrary to previous studies, this study did not find significant differences in THA outcomes and QOL between statin-exposed and non-statin cohorts. This disparity may be a result of differences in study design, patient populations, and the timing of statin initiation relative to surgery. The findings of this study should be validated through larger studies to assess the effects of statin use more firmly.</p>","PeriodicalId":18549,"journal":{"name":"Medicine","volume":"104 14","pages":"e42074"},"PeriodicalIF":1.3,"publicationDate":"2025-04-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143803329","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}