Medicine最新文献

{"title":"Elevated isoleucine may be a protective factor for primary hypertension: A pooled causal effect study.","authors":"Ying Shi, Hairun Liu, Yi Chen","doi":"10.1097/MD.0000000000041651","DOIUrl":"10.1097/MD.0000000000041651","url":null,"abstract":"<p><p>Hypertension continues to pose a huge burden to global public health. Abnormal metabolism not only serves as a risk factor for hypertension but also acts as a driving force in its aggravation. However, there remains a lack of large-scale causal demonstration based on extensive samples. Our study aims to investigate the causal relationship between metabolism and primary hypertension (PH) using Mendelian randomization analysis. We used genome-wide association studies instrumental variables for Mendelian randomization association analysis integrating the diagnosis results of PH in 3 populations from East Asia, the Middle East, and Africa with serum metabolites and metabolite ratios. This allowed us to identify predictive metabolites and metabolic pathways for diagnosing or treating PH. Inverse-variance weighting was the main model for establishing causal associations. In addition horizontal pleiotropy test, linkage disequilibrium test, and sensitivity analysis were employed to test the explanatory power of instrumental variables. A total of 10,922 cases of PH and 8299 cases of metabolomics detection cohorts were included in the study. In East Asian, Middle Eastern, and African populations, we found 36, 57, and 40 known metabolites respectively strongly associated with PH (P < .05). Cross-section and meta-analysis of these strongly correlated metabolites across the 3 ethnic groups revealed 7 common metabolites. Notably, elevated isoleucine (odds ratio = 0.74, 95% confidence interval: 0.56-0.96) was demonstrated as a potential protective factor against PH across 3 ethnic groups. The metabolites associated with PH have certain polymorphisms in different populations. Isoleucine may be a promising biomarker for PH diagnosis or treatment, but more clinical validation is needed.</p>","PeriodicalId":18549,"journal":{"name":"Medicine","volume":"104 9","pages":"e41651"},"PeriodicalIF":1.3,"publicationDate":"2025-02-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11875580/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143527838","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Endoscopic submucosal dissection combined surgery for the treatment of ectopic gastric mucosa and ectopic pancreas in muscularis propria and serosal layer of the stomach: A rare case report and review of the literature.","authors":"Yindi Chen, Yanbing Cao, Lingran Zhi, Rui Huang","doi":"10.1097/MD.0000000000041297","DOIUrl":"10.1097/MD.0000000000041297","url":null,"abstract":"<p><strong>Rationale: </strong>Ectopic gastric mucosa (EGM) and ectopic pancreas (EP) in the stomach is a rare congenital anomaly. No research on the coexistence of EGM and EP in the stomach has been found. However, several studies have shown canceration of EGM outside the stomach and EP. Active surgical treatment may be necessary. This paper introduces a new case of ectopic gastric mucosa and ectopic pancreas in muscularis propria and serosal layer of the stomach and which were ultimately removed by endoscopic submucosal dissection combined surgery.</p><p><strong>Patient concerns: </strong>The patient was a 25-year-old male. Upper gastrointestinal endoscopy showed a subepithelial lesion in gastric antrum.</p><p><strong>Diagnoses: </strong>Postoperative pathology confirmed a diagnosis of EGM and EP.</p><p><strong>Interventions: </strong>Enhanced computed tomography scan and endoscopic ultrasonography showed a submucosal tumor. Then endoscopic submucosal dissection was performed, during which a lesion was observed on the anterior wall of the stomach near the pylorus. This lesion invades the muscularis propria of the stomach and the large lesions near the pylorus may lead to pyloric obstruction. Considering these situations comprehensively, the patient ultimately underwent surgical resection of gastric lesion and partial gastrectomy.</p><p><strong>Outcomes: </strong>After 3 months of follow-up, the patient was recovering well and no recurrence of the lesion was found so far.</p><p><strong>Lessons: </strong>EGM along with EP in the stomach is a rare condition. Due to its rarity, there was a lack of sufficient data support for its treatment and prognosis. Due to the EGM and EP may become cancerous, clinical attention should be paid to it. In this study, we present a new case report of EGM along with EP in the stomach and review the existing literature to explore treatment options for it.</p>","PeriodicalId":18549,"journal":{"name":"Medicine","volume":"104 9","pages":"e41297"},"PeriodicalIF":1.3,"publicationDate":"2025-02-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11875626/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143527842","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Global systematic mapping of Vibrio species pathogenicity: A PRISMA-guided cluster-based analysis.","authors":"Hope Onohuean, Uchechukwu U Nwodo","doi":"10.1097/MD.0000000000041664","DOIUrl":"10.1097/MD.0000000000041664","url":null,"abstract":"<p><strong>Background: </strong>A systematic global map on toxigenesis and genomic virulence of Vibrio spp. was analyzed for research progress to identify the emerging research patterns for establishing a database for designing future interventions.</p><p><strong>Method: </strong>The databases (Web of Science and Scopus) were analyzed with Voxviewer software to map the global scale of Vibrio spp. or virulence toxin/genes publications and standardized using Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) strategies.</p><p><strong>Results: </strong>The results identified 1162 (Web of Science n = 620, Scopus n = 542), while 314 studies qualified for inclusion and were significantly analyzed on virulence toxin/genes. By co-citation analysis, 4-thematic clusters were developed from 6420 citations and a total reference of 9062. Cluster #1 (pathogenesis & virulence factors) and cluster #4 (host response factors) generated the utmost publications and citations (n = 40, 643) and the least (n = 7, 85) interest by the researcher. Whereas 8-thematic clusters were developed by bibliographic coupling technique analysis, cluster#1 and cluster#8 generated the utmost (n = 78, 1684) and least (n = 7, 81) publications and citations interest by the researcher.</p><p><strong>Conclusions: </strong>Our findings suggest that Vibrio toxigenesis and virulence factors are a complex field requiring an interdisciplinary approach consisting of interconnected perspectives that have important consequences for academics and policymakers.</p>","PeriodicalId":18549,"journal":{"name":"Medicine","volume":"104 9","pages":"e41664"},"PeriodicalIF":1.3,"publicationDate":"2025-02-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11875588/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143527853","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Higher dose of rivaroxaban for the treatment of venous thromboembolism in a 15-year-old Asian child with antithrombin deficiency: A case report and literature review.","authors":"Chun-Su Liang, Yue-Xin Chen, Fang Liu, Yue-Dong Yue, Li-Ping Du","doi":"10.1097/MD.0000000000041629","DOIUrl":"10.1097/MD.0000000000041629","url":null,"abstract":"<p><strong>Rationale: </strong>Deficiency in antithrombin (AT) can significantly increase the risk of venous thromboembolism (VTE). However, there is insufficient data on the efficacy and safety of anticoagulants in patients with AT deficiency, especially in children. In addition, Asian populations typically require a lower dose of rivaroxaban, and this may be even more pronounced in Asian children. This case aims to explore the potential efficacy and safety of a higher dose of rivaroxaban in an Asian child with AT deficiency and VTE.</p><p><strong>Patient concerns: </strong>A 15-year-old boy was referred to our center with severe deep vein thrombosis progression. The primary concern was the effective management of the thromboembolic events while minimizing the risk of bleeding, given the patient's young age and AT deficiency.</p><p><strong>Diagnoses: </strong>The patient was diagnosed with pulmonary embolism and deep vein thrombosis with AT deficiency.</p><p><strong>Interventions: </strong>The patient was treated with a higher dose of rivaroxaban, which was 15 mg twice a day for 3 weeks, followed by 20 mg per day for 6 months, which was a relatively high dose for an Asian child.</p><p><strong>Outcomes: </strong>During the follow-up period, the patient did not experience any VTE events or bleeding events.</p><p><strong>Lessons: </strong>This case provides additional data on the efficacy and safety of direct oral factor Xa inhibitors in patients with VTE and AT deficiency. It suggests that for Asian children with AT deficiency, considering a higher dose of rivaroxaban could be beneficial, especially when the children's height, weight, and age are close to adults.</p>","PeriodicalId":18549,"journal":{"name":"Medicine","volume":"104 9","pages":"e41629"},"PeriodicalIF":1.3,"publicationDate":"2025-02-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11875584/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143527859","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"HLA genotyping in cardiac and other extrapulmonary manifestations of sarcoidosis.","authors":"Ece Ünüvar Şenay, Celalettin Korkmaz, Ayşegül Zamani, Adil Zamani, Soner Demirbaş, Mahmut Selman Yildirim","doi":"10.1097/MD.0000000000041640","DOIUrl":"10.1097/MD.0000000000041640","url":null,"abstract":"<p><strong>Background: </strong>Although numerous candidate genes have been identified in studies investigating the role of genetics in sarcoidosis, the strongest association has been reported with the Major Histocompatibility Complex/Human Leucocyte Antigen (MHC/HLA) region. This study aimed to evaluate HLA polymorphism and assess its association with cardiac and other extrapulmonary involvement in sarcoidosis patients.</p><p><strong>Methods: </strong>The study included 67 patients diagnosed with sarcoidosis. A control group of 100 bone marrow donors, who had undergone HLA genotyping previously, was also included. Blood samples were collected from all participants for HLA gene polymorphism analysis. The differences in HLA genotypes were investigated between patients with and without cardiac and other extrapulmonary involvement, and between these groups and the control group.</p><p><strong>Results: </strong>Cardiac involvement, was present in 17.9% of the patients. The most frequently affected extrapulmonary organ was the skin (23.8%). HLA DQB103 and HLA DQB106 alleles were expressed more frequently in patients with only pulmonary involvement compared to those with extrapulmonary involvement. Conversely, HLA DQA101 was expressed more frequently in patients with extrapulmonary involvement. No statistically significant difference in the expression of HLA DRB1, HLA DQB1, and HLA DQA1 alleles was observed between sarcoidosis patients with and without cardiac involvement.</p><p><strong>Conclusion: </strong>Our findings suggest that HLA DQB103 and HLA DQB106 alleles might be protective against extrapulmonary organ involvement, while HLA DQA101 could be a risk factor. These findings may contribute to the prediction of treatment response and prognosis in sarcoidosis patients.</p>","PeriodicalId":18549,"journal":{"name":"Medicine","volume":"104 9","pages":"e41640"},"PeriodicalIF":1.3,"publicationDate":"2025-02-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11875599/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143527862","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evaluation of healthcare professionals' knowledge of Alzheimer's disease in government hospitals and healthcare centers: A cross-sectional study in Jeddah, Saudi Arabia.","authors":"Yahya A Alzahrani, Maan H Harbi, Adel G Almalki, Rana A Althomali, Roaa F Alorabi, Bashaer S Basulyman, Khawla A Alansari, Jasser A Alzahrani, Dalia A Alzahrani, Ibrahim A Asuhaimi, Abdullah M Alzahrani, Ayed A Alkatheeri","doi":"10.1097/MD.0000000000041642","DOIUrl":"10.1097/MD.0000000000041642","url":null,"abstract":"<p><p>Knowledge of Alzheimer's disease (AD) among healthcare staff influences important aspects of care and is associated with better patient outcomes. This study aimed to assess the knowledge of AD among healthcare professionals working in government hospitals and healthcare centers in Jeddah, Saudi Arabia. This cross-sectional study used an online questionnaire to assess Alzheimer's disease knowledge using the Alzheimer's Disease Knowledge Scale (ADKS). Participants also self-rated their knowledge and reported their experience in dementia care and training. The study included 231 healthcare professionals, with 61.5% males and 38.5% females. Medical professionals demonstrated significantly higher mean ADKS score = 19.84 compared to pharmacy, nursing, and allied health professionals (P < .05). Other factors, such as gender, age, workplace setting, years of experience, and formal dementia training, showed no significant impact on ADKS scores (P > .05). However, participants with additional dementia-related learning experiences, such as workshops or self-directed study, had significantly higher scores (P < .05). A notable finding was the discrepancy between self-assessed and actual knowledge. Among those who rated themselves as \"very knowledgeable,\" only 10% achieved a very good ADKS score, while more than half failed the test. Conversely, those who rated themselves as having poor knowledge often performed better than expected, with many achieving good or very good ADKS scores 44.3% and 13.1%, respectively. This study highlights significant disparities in Alzheimer's disease knowledge among healthcare professionals in Jeddah, with medical staff showing higher understanding. Tailored educational programs are needed to address these gaps and improve dementia care.</p>","PeriodicalId":18549,"journal":{"name":"Medicine","volume":"104 9","pages":"e41642"},"PeriodicalIF":1.3,"publicationDate":"2025-02-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11875628/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143527829","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Identification of ferroptosis-related genes in heart tissues of patients with hypertrophic cardiomyopathy.","authors":"Fang Huang, Shujuan Li, Ailei Zhang, Jihuai Zhao, Shaoqiang Zhang, Dongwei Liu, Wei Chen","doi":"10.1097/MD.0000000000041525","DOIUrl":"10.1097/MD.0000000000041525","url":null,"abstract":"<p><strong>Background: </strong>This study aims to investigate the role of ferroptosis in hypertrophic cardiomyopathy (HCM), a genetic disorder characterized by abnormal thickening of the heart muscle. The objective is to identify differentially expressed genes associated with ferroptosis in HCM and understand the potential molecular mechanisms underlying the disease.</p><p><strong>Methods: </strong>Comprehensive genomic analysis was conducted to identify differentially expressed genes associated with ferroptosis in HCM. The analysis focused on TFRC, SCD, SLC2A1, EGR1, GDF15, SNCA, PLIN2, and NQO1 as hub genes regulating ferroptosis. Functional enrichment analysis was performed to uncover their involvement in pathways such as ferroptosis, ubiquinone biosynthesis, and HIF-1 signaling. In addition, immune cell infiltration patterns in HCM were explored, and associations between the hub genes and immune infiltration were identified.</p><p><strong>Results: </strong>The analysis revealed TFRC, SCD, SLC2A1, EGR1, GDF15, SNCA, PLIN2, and NQO1 as hub genes involved in the regulation of ferroptosis in HCM. Functional enrichment analysis indicated their contribution to key pathways related to ferroptosis, ubiquinone biosynthesis, and HIF-1 signaling. Furthermore, associations between the hub genes and immune infiltration in HCM were observed.</p><p><strong>Conclusion: </strong>This study provides valuable insights into the molecular basis of HCM by identifying differentially expressed genes associated with ferroptosis. The findings suggest potential molecular mechanisms underlying the development of HCM. These findings contribute to a better understanding of HCM and may pave the way for the development of targeted therapies and improved diagnostic approaches for this debilitating cardiac disorder.</p>","PeriodicalId":18549,"journal":{"name":"Medicine","volume":"104 9","pages":"e41525"},"PeriodicalIF":1.3,"publicationDate":"2025-02-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11875581/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143527891","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Journals with \"pain\" in their titles: A web of science-based bibliometric analysis.","authors":"Shao-Yu Chi, Wei-Ting Wu, Ke-Vin Chang, Levent Özçakar","doi":"10.1097/MD.0000000000041732","DOIUrl":"10.1097/MD.0000000000041732","url":null,"abstract":"<p><strong>Background: </strong>Pain, a critical symptom prevalent in various diseases and syndromes, has garnered increased attention in recent scientific literature. Bibliometric analyses can offer valuable multi-disciplinary insights into pain. This bibliometric analysis focused on journals with \"pain\" in their titles.</p><p><strong>Methods: </strong>Using the Master Journal List in the Web of Science (WoS) database (up to December 31, 2024), we searched all the journals indexed in Science Citation Index Expanded (SCIE) or Social Sciences Citation Index (SSCI) with \"pain\" in their titles. For further analyses, we extracted data about the journals including publisher, country, language, frequency, SCIE/SSCI categories, journal impact factor, and citation.</p><p><strong>Results: </strong>We identified 19 journals with \"pain\" in their titles. All the included journals were indexed in SCIE, with Pain Management Nursing also indexed in SSCI. More than half of the journals were published in the United States of America or the United Kingdom, and all were in English. Regarding the SCIE categories, 13 journals were listed in \"clinical neurology,\" 8 in \"anesthesiology,\" and 5 in \"neurosciences.\" From 2018 to 2022, either Pain or Journal of Headache and Pain maintained the highest impact factor. Furthermore, Pain held the record for the most citable articles and reviews and the most total citations in 2022.</p><p><strong>Conclusion: </strong>This study is the first bibliometric analysis of journals, rather than articles, in the field of pain. Pain is the most recognized journal in the field, with the highest number of citations and the highest average impact factor. In the future, bibliometric studies should explore other relevant journals without the word \"pain\" in their titles, in order to gain a more comprehensive understanding of the scientific literature on pain studies.</p>","PeriodicalId":18549,"journal":{"name":"Medicine","volume":"104 9","pages":"e41732"},"PeriodicalIF":1.3,"publicationDate":"2025-02-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11875597/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143527896","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Correction of upper eyelid retraction following ptosis surgery using Hering's law: A case report.","authors":"Runhui Pang, Zhaochuan Liu, Huixing Wang, Juan Wang, Junhu Shi, Li Xiao, Ping Bai","doi":"10.1097/MD.0000000000041624","DOIUrl":"10.1097/MD.0000000000041624","url":null,"abstract":"<p><strong>Rationale: </strong>Blepharoptosis is a common disorder characterized by abnormal eyelid position that affects both visual function and esthetics. Postoperative upper eyelid retraction, which is often due to overcorrection, is a major problem. Under normal circumstances, the operation is usually performed on the overcorrected eye. Here, we present the case of a patient who had previously undergone surgery to correct right upper blepharoplasty, which resulted in asymmetry. Utilizing Hering's law, we decided to correct only the left eye, resulting in remarkable bilateral symmetry after surgery. This proves that for patients with ptosis after upper eyelid surgery, a comprehensive approach should be considered rather than just one treatment method.</p><p><strong>Patient concerns: </strong>Here, we report a case of overcorrection of ptosis in a male patient who underwent corrective surgery.</p><p><strong>Diagnoses: </strong>Based on the patient's ocular examination, appearance, medical history, measurement of levator muscle strength, and MRD1 measurement, the diagnosis was postoperative overcorrection of ptosis of the right upper eyelid.</p><p><strong>Interventions: </strong>In this case, preoperative examination revealed a reduction in the size of the right eye when the left eyelid was lifted, which was in accordance with Hering's law. Consequently, surgical intervention was limited to the left eye, resulting in excellent bilateral symmetry after surgery.</p><p><strong>Outcomes: </strong>The surgery was successful and resulted in symmetry between both eyes. We followed up with the patient for a year and he was extremely satisfied with the surgical results. The outpatient follow-up revealed no discomfort.</p><p><strong>Lessons: </strong>Postoperative upper eyelid retraction following monocular ptosis correction is a rare condition. The conventional treatment approach typically involves reoperation on the affected eye. However, considering the importance of Hering's law in the management of ptosis, excellent outcomes were achieved in this case through surgery on the contralateral, unaffected eye. When treating a patient, the operation should be tailored to their specific condition.</p>","PeriodicalId":18549,"journal":{"name":"Medicine","volume":"104 9","pages":"e41624"},"PeriodicalIF":1.3,"publicationDate":"2025-02-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11875631/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143527789","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Epidemiology of lateral and medial epicondylitis in South Korea: A nationwide population-based study.","authors":"Bong Gun Lee, Young Seok Lee, Chang-Hun Lee, Wan-Sun Choi, Seung Hun Baek, Young-Hoon Jo","doi":"10.1097/MD.0000000000041588","DOIUrl":"10.1097/MD.0000000000041588","url":null,"abstract":"<p><p>Few studies have reported the epidemiology of lateral epicondylitis (LE) and medial epicondylitis (ME) in nationwide databases. This study aimed to investigate the epidemiology of LE and ME in South Korea. We analyzed data from the nationwide database of the Korean Health Insurance Review and Assessment Service from 2013 to 2017. We investigated the incidence, prevalence, and surgical trends in patients with LE or ME. Between 2013 and 2017, we identified 2813,431 and 836,610 patients with LE and ME, respectively. LE and ME were more frequently diagnosed in women than in men. During the study period, the mean annual age-adjusted incidence rates of LE and ME were 9.7 per 1000 people and 2.9 per 1000 people, respectively. The incidence of LE did not change significantly during the study period, but the prevalence rate increased significantly. Conversely, the incidence and prevalence rates of ME have significantly increased. Furthermore, 0.8% and 1.0% of patients with LE and ME, respectively, required surgical treatment, showing an annual increase in the number of surgical treatments for LE and ME, respectively. The proportion of arthroscopic surgeries performed for LE did not significantly change during the study period. The prevalence of LE and ME has increased in South Korea. Consequently, the number of surgeries performed annually for LE and ME has increased.</p>","PeriodicalId":18549,"journal":{"name":"Medicine","volume":"104 9","pages":"e41588"},"PeriodicalIF":1.3,"publicationDate":"2025-02-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11875595/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143527850","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}