Medicine最新文献

{"title":"Association of multiple inflammatory index markers with overactive bladder syndrome: A cross-sectional study results from the NHANES 2005 to 2018.","authors":"Mingchu Jin, Jie Xu, Heng Liu, Yu Zhou, Haidong Hao, Yutang Yuan, Hongtao Jia","doi":"10.1097/MD.0000000000045154","DOIUrl":"https://doi.org/10.1097/MD.0000000000045154","url":null,"abstract":"<p><p>The Systemic Inflammatory Response Index (SIRI), neutrophil/lymphocyte ratio, Aggregate Inflammatory Syndrome Index, monocyte/lymphocyte ratio, platelet/lymphocyte ratio, and Systemic Inflammatory Index are readily accessible inflammatory biomarkers. The pathogenesis of overactive bladder (OAB) is considered related to the inflammatory response. This study aims to explore the relationships between these biomarkers and OAB and to assess their potential as predictors of disease onset. This study is a retrospective cross-sectional analysis utilizing data from the National Health and Nutrition Examination Survey from 2005 to 2018. Given the preexisting nature of the National Health and Nutrition Examination Survey data collection, this study retrospectively evaluates the association between systemic inflammatory markers and OAB based on previously recorded clinical and demographic variables. A total of 32,115 participants were analyzed. Our findings demonstrated a significant association between systemic inflammatory markers and OAB. Among the inflammatory indices, SIRI (odds ratio [OR] = 1.184, 95% confidence interval [95% CI]: 1.150-1.220, P < .001), neutrophil/lymphocyte ratio (OR = 1.116, 95% CI: 1.091-1.141, P < .001), and monocyte/lymphocyte ratio (OR = 2.632, 95% CI: 2.116-3.275, P < .001) exhibited the strongest association with OAB. Receiver operating characteristic analysis indicated that SIRI had the highest predictive value (area under the curve = 0.549, 95% CI: 0.541-0.557, P < .05). These findings suggest that systemic inflammation may play a crucial role in OAB pathogenesis. Levels of the biomarkers were significantly correlated with the incidence of OAB. In the U.S., individuals with elevated levels of these markers exhibited a higher prevalence of OAB.</p>","PeriodicalId":18549,"journal":{"name":"Medicine","volume":"104 41","pages":"e45154"},"PeriodicalIF":1.4,"publicationDate":"2025-10-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145292773","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Causal associations between biomarkers and depression: A Mendelian randomization study.","authors":"Jian Guo, Yang Jiang, Kaiqin Chen, Jingwen Li, Xuefeng Wang","doi":"10.1097/MD.0000000000045105","DOIUrl":"https://doi.org/10.1097/MD.0000000000045105","url":null,"abstract":"<p><p>Depression is one of the most prevalent and debilitating mental health conditions worldwide. Biomarkers have received considerable attention in depression research, to provide breakthroughs in early diagnosis, pathophysiological understanding, and personalized treatment. We employed Mendelian randomization (MR) methods to examine the causal connection between biomarkers and genetic predisposition to depression. Leveraging a substantial cohort from publicly accessible genome-wide association study datasets of European populations, we analyzed MR, utilizing the inverse variance weighting model as the primary approach. Additionally, we evaluated heterogeneity and horizontal pleiotropy. Our MR analysis revealed significant associations between biomarkers and depression. The inverse variance weighting model indicated that urinary potassium (odds ratio [OR] = 0.670, P = .012, β = -0.4), peak expiratory flow (OR = 0.886, P = .011, β = -0.143), cholesterol levels (OR = 0.935, P = .00508, β = -0.0674), and direct low-density lipoprotein levels (OR = 0.925, P = .00303, β = -0.0782) were associated with a reduced risk of depression. Conversely, triglyceride levels (OR = 1.05, P = .0246, β = 0.0489) were associated with a higher risk of developing depression. This study found that urinary potassium, peak expiratory flow, cholesterol levels, and direct low-density lipoprotein levels were associated with a reduced risk of depression. In contrast, triglyceride levels were correlated with a heightened risk of depression.</p>","PeriodicalId":18549,"journal":{"name":"Medicine","volume":"104 41","pages":"e45105"},"PeriodicalIF":1.4,"publicationDate":"2025-10-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145292783","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Systemic inflammation response index (SIRI) predicts mortality and cardiovascular events in maintenance hemodialysis patients: A correlational study.","authors":"Shen Jinwei, Mai Weikang, Huang Ying, Wen Yueqiang, Zhang Ying, Hong Dongxi, Huang Qian, Gao Youqun, Di Hui, Cao Xueli","doi":"10.1097/MD.0000000000044927","DOIUrl":"https://doi.org/10.1097/MD.0000000000044927","url":null,"abstract":"<p><p>Maintenance hemodialysis (MHD) patients generally experience a state of micro-inflammation, which increases the risk of all-cause mortality and cardiovascular events (CVEs). The systemic inflammatory response index (SIRI) is a novel inflammatory marker that reflects the body's inflammatory state. Research has shown that SIRI not only serves as a prognostic indicator for many cancer-related diseases but also as a predictor for the occurrence of cardiovascular and cerebrovascular diseases. Currently, there is a paucity of research investigating the correlation between SIRI and all-cause mortality or the incidence of CVEs in patients undergoing MHD. This study is a retrospective cohort study, which collected 275 newly admitted MHD patients. The study population was divided into 2 groups based on the median value of SIRI. Kaplan-Meier cumulative incidence curves, multivariable logistic regression analysis, and competing risk model analysis were used to investigate the correlation between SIRI and all-cause mortality and CVE in MHD patients. Of all the patients, 275 cases of newly admitted MHD patients were recorded. Restricted cubic spline analysis revealed a linear association between the SIRI and all-cause morality as well as CVE. The Kaplan-Meier curves demonstrated differences in both all-cause mortality and CVE between the 2 groups. The competitive risk model suggested a significant difference in the cumulative incidence of all-cause mortality and CVE between the 2 groups. Compared to low SIRI group, adjusted Cox model showed that high SIRI group was associated with increased risk of all-cause mortality and CVE (all-cause mortality: odds ratio, 3.652; 95% confidence interval 1.812-7.363; P < .001; new-onset CVEs: odds ratio, 2.224; 95% confidence interval 1.191-4.155; P = .012). High SIRI levels are independent risk factors for all-cause mortality and CVEs in MHD patients.</p>","PeriodicalId":18549,"journal":{"name":"Medicine","volume":"104 41","pages":"e44927"},"PeriodicalIF":1.4,"publicationDate":"2025-10-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145292811","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Plasma proteins and the risk of inflammatory bowel diseases: A two-sample Mendelian randomization study.","authors":"Zheng Jiao, Ge-Ge Li, Ling-Shuo Bai, Jian-Zeng Guo, Li-Jian Pang","doi":"10.1097/MD.0000000000044738","DOIUrl":"https://doi.org/10.1097/MD.0000000000044738","url":null,"abstract":"<p><p>Dysregulated plasma proteins are therapeutic targets for inflammatory bowel disease (IBD), which is a major global health burden. There is limited causal evidence for these associations. Mendelian randomization (MR) was applied to assess the genetic links between plasma proteins and IBD risk. Genetic instruments for 3282 plasma protein phenotypes were derived from genome-wide association studies (GWAS). Summary statistics from IBD GWAS (overall, Crohn disease [CD] and ulcerative colitis [UC]) were analyzed via inverse-variance weighted (IVW) regression, estimating odds ratios (OR) and 95% confidence intervals (CI). Four proteins showed associations with overall IBD risk: erythrocyte band 7 integral membrane protein (OR = 0.84, 95% CI = 0.77-0.90), Interleukin-1 receptor-like 1 (IL1RL1; OR = 1.07, 1.04-1.10), Interleukin-18 receptor 1 (IL18R1; OR = 1.08, 1.04-1.12), and alcohol dehydrogenase 1 B (ADH1B; OR = 0.85, 0.79-0.91). Subtype analyses revealed CD-specific associations with erythrocyte band 7 (OR = 0.82, 0.76-0.90) and IL1RL1 (OR = 1.10, 1.05-1.14), while UC risk correlated with ADH1B (OR = 0.85, 0.78-0.91) and high-affinity immunoglobulin gamma Fc receptor I (FCGR1A; OR = 0.82, 0.75-0.90). This MR study identified causal associations between specific plasma proteins (erythrocyte band 7, IL1RL1, IL18R1, ADH1B, and FCGR1A) and IBD pathogenesis, with distinct molecular profiles for CD and UC. These findings implicate dysregulated innate immunity and metabolic pathways, offering mechanistic insights into therapeutic development. Further validation of protein-mediated mechanisms is warranted.</p>","PeriodicalId":18549,"journal":{"name":"Medicine","volume":"104 41","pages":"e44738"},"PeriodicalIF":1.4,"publicationDate":"2025-10-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145292817","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Midpalatal suture bone regeneration following customized miniscrew-assisted rapid palatal expansion in nongrowing patients: A retrospective observational study.","authors":"Pham Thi Hong Thuy, Hoang Viet, Pham Thu Trang, Dang Phuong Linh, Nguyen Viet Anh","doi":"10.1097/MD.0000000000044624","DOIUrl":"https://doi.org/10.1097/MD.0000000000044624","url":null,"abstract":"<p><p>This study aimed to evaluate midpalatal suture bone regeneration after customized miniscrew-assisted rapid palatal expansion (MARPE) in nongrowing patients using cone-beam computed tomography (CBCT) over a 12-month period. An observational study including 40 nongrowing patients diagnosed with transverse maxillary deficiency was conducted. Customized MARPE was performed, and CBCT scans were obtained at baseline (T0), 6 months (T1), and 12 months (T2) post-expansion. Bone density measurements were taken at the anterior, median, and posterior regions of the midpalatal suture. Statistical analyses included paired t-tests, repeated measures ANOVA, and chi-square tests. Significant reductions in bone density were observed at 6 months post-expansion in all regions. By 12 months, bone density had substantially recovered, with the median region even exceeding baseline values. Younger patients (<18 years) and those with expansion widths < 5 mm demonstrated faster and more complete bone regeneration. Visual scoring on CBCT confirmed complete suture healing in all patients by 12 months. Customized MARPE effectively promotes midpalatal suture expansion and subsequent bone regeneration in nongrowing patients. Complete bone healing was evident within 1-year, particularly among younger individuals and those with smaller expansion widths, supporting the efficacy of customized MARPE as a nonsurgical treatment option for transverse maxillary deficiency.</p>","PeriodicalId":18549,"journal":{"name":"Medicine","volume":"104 41","pages":"e44624"},"PeriodicalIF":1.4,"publicationDate":"2025-10-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145292824","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effects of epidural labor analgesia on intrapartum fever and obstetric outcomes in women with gestational diabetes mellitus: A retrospective cohort study.","authors":"Xiongda Lin, Qiaolin Xie, Yibin Xu, Longyuan Shen, Jianfeng Lian, Quansheng Xiao","doi":"10.1097/MD.0000000000045108","DOIUrl":"https://doi.org/10.1097/MD.0000000000045108","url":null,"abstract":"<p><p>Gestational diabetes mellitus (GDM) is a common metabolic disorder during pregnancy, closely associated with adverse maternal and neonatal outcomes. Epidural labor analgesia (ELA) is widely used for pain relief during labor, but it has also been linked to an increased incidence of intrapartum fever. Although previous studies have explored the effects of ELA on the general population, it remains unclear whether it has a greater impact on women with GDM, leading to higher risks of intrapartum fever, prolonged labor, and adverse mode of delivery. This retrospective cohort study included 234 parturients between January and December 2023, categorized into 3 groups: Group A (GDM with ELA, n = 85), Group B (GDM without ELA, n = 64), and Group C (non-GDM with ELA, n = 85). To reduce potential confounding, propensity score matching (PSM) was applied. The primary outcomes assessed were intrapartum fever incidence, labor duration, and mode of delivery. Group A had significantly longer labor durations (688.99 ± 400.54 minutes vs 377.97 ± 319.66 minutes, P < .01), higher cesarean delivery rates (14.10% vs 4.70%, P = .01), and a greater incidence of intrapartum fever (21.20% vs 1.60%, P < .01) compared to Group B. No statistically significant differences were found between Group A and Group C. In nulliparous women with GDM, ELA is associated with prolonged labor, increased cesarean delivery rates, and a higher risk of intrapartum fever. These findings suggest that individualized analgesic strategies should be considered in GDM pregnancies to minimize potential complications.</p>","PeriodicalId":18549,"journal":{"name":"Medicine","volume":"104 41","pages":"e45108"},"PeriodicalIF":1.4,"publicationDate":"2025-10-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145292826","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The role and diagnostic progress of exosomes in childhood allergic asthma: A review.","authors":"Baohe Liu, Tingting Zu, Lulu Gu, Shuyin Fu, Fanglong Sun, Fuling Wu","doi":"10.1097/MD.0000000000045092","DOIUrl":"https://doi.org/10.1097/MD.0000000000045092","url":null,"abstract":"<p><p>Allergic asthma in children is a chronic respiratory disease that is characterized by airway inflammation and hyperresponsiveness. Prolonged chronic inflammatory stimulation contributes to the irreversible remodeling of the airways. Currently, there is a high prevalence in childhood, yet a low rate of diagnosis and effective control. This highlights an urgent need to identify a diagnostic tool with high sensitivity and specificity, as well as an effective therapeutic approach. In comparison with the conventional diagnostic and therapeutic techniques for bronchial asthma, exosome technology is capable of detecting minute alterations in asthma-related lung tissue cells at an earlier stage and monitoring airway inflammation in a timely manner. This has the potential to evolve into a highly accurate diagnostic and therapeutic instrument for allergic asthma in children.</p>","PeriodicalId":18549,"journal":{"name":"Medicine","volume":"104 41","pages":"e45092"},"PeriodicalIF":1.4,"publicationDate":"2025-10-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145292836","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Systemic treatment of metastatic castration-sensitive prostate cancer: A meta-analysis of efficacy and safety.","authors":"Minhao Zhang, Lilin Wan, Yong Yao, Rongzu Wu, Wenchao Li, Peng Gu","doi":"10.1097/MD.0000000000042318","DOIUrl":"https://doi.org/10.1097/MD.0000000000042318","url":null,"abstract":"<p><strong>Background: </strong>Within the last 10 years, multiple clinical randomized controlled trials in metastatic castration-sensitive prostate cancer patients (mCSPC) have demonstrated that androgen deprivation therapy (ADT) combination therapy is significantly superior to ADT alone. However, there are no guidelines that recommend the best clinical decisions with regard to multi-selective systemic therapy for mCSPC.</p><p><strong>Methods: </strong>Two independent researchers have conducted a systematic literature search of the Cochrane Central, Web of Science, Clinical Trials. gov and EU Clinical Trial Register databases with a search deadline of July 5, 2022. Hazard Ratio (HR) and 95% confidence intervals were analyzed and extracted for overall and progression-free survival and their subgroups, as well as the number of adverse events. Trial quality was assessed through the Risk of Bias Form and the Newcastle-Ottawa Scale, and systematic reviews and meta-analyses were carried out in strict accordance with the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) project.</p><p><strong>Results: </strong>8704 patients from 7 studies participated in trials comparing the effectiveness of 4 ADT combination treatments (including ADT + docetaxel, ADT + abiraterone acetate, ADT + enzalutamide, ADT + apalutamide) and ADT alone (ADT + placebo/no-treatment). The results suggested that ADT combination therapy was significantly better than ADT alone. Furthermore, based on the patient's initial clinical characteristics and expected prognosis, we tentatively provided relevant optimal treatment options.</p><p><strong>Conclusions: </strong>ADT + ARAT outperformed ADT ± docetaxel in OS/PFS for mCSPC, with strategies tailored to patient profiles. Future work will leverage advanced analytics and standardized reporting; direct combination trials are critical for precise guidance.</p>","PeriodicalId":18549,"journal":{"name":"Medicine","volume":"104 41","pages":"e42318"},"PeriodicalIF":1.4,"publicationDate":"2025-10-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145292838","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Impact of renal dysfunction on prognosis in patients with severe heart failure: A retrospective cohort study.","authors":"Jia Li, Yiming Chu, Minmin Huang","doi":"10.1097/MD.0000000000044405","DOIUrl":"https://doi.org/10.1097/MD.0000000000044405","url":null,"abstract":"<p><p>This study aims to investigate the prevalence of renal insufficiency and its prognostic impact on patients with severe heart failure (HF), particularly those classified as New York Heart Association class IV, and to identify independent clinical predictors associated with renal dysfunction in this population. This retrospective cohort study analyzed clinical data from 120 patients hospitalized with New York Heart Association class IV HF between June 1, 2020, and June 30, 2023. Based on eGFR at admission, patients were categorized into 3 groups: normal renal function (eGFR ≥ 90 mL/min/1.73 m²), mild renal insufficiency (60 ≤ eGFR < 90 mL/min/1.73 m²), and moderate-to-severe renal insufficiency (eGFR < 60 mL/min/1.73 m²). Demographic, biochemical, and survival data were collected and analyzed using multivariate regression and Kaplan-Meier survival analysis. Renal insufficiency was identified in 66.67% of the patients, with 33.33% having normal renal function, 35.00% having mild renal insufficiency, and 31.67% having moderate-to-severe renal insufficiency. Multivariate analysis revealed that age (OR = 1.422, P = .041), serum creatinine (OR = 2.951, P = .016), blood urea nitrogen (OR = 2.287, P = .026), and triiodothyronine levels (OR = 0.646, P = .040) were independently associated with renal dysfunction in this cohort. Patients with moderate-to-severe renal insufficiency experienced significantly higher rates of all-cause mortality (47.37% vs 22.50% in the normal renal function group and 35.71% in the mild renal insufficiency group, P = .033) and rehospitalization (60.53% vs 40.00% in the normal renal function group and 45.24% in the mild renal insufficiency group, P = .027). Kaplan-Meier analysis showed that the median survival was shortest in the moderate-to-severe renal insufficiency group (5.50 months), in contrast to 10.80 months in the mild renal insufficiency group and 11.25 months in the normal renal function group (P < .001). Moderate-to-severe renal insufficiency is highly prevalent among patients with advanced HF and is associated with significantly worse clinical outcomes. These findings underscore the importance of early detection and tailored management strategies to improve survival and reduce rehospitalization in this high-risk population.</p>","PeriodicalId":18549,"journal":{"name":"Medicine","volume":"104 41","pages":"e44405"},"PeriodicalIF":1.4,"publicationDate":"2025-10-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145292842","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Mendelian randomization analysis unveiling the genetic connection: How psychiatric disorders heighten cancer risk.","authors":"Jian Wang, Ruxue Lv, Sili Xiong, Hui Wang, Qin Zeng","doi":"10.1097/MD.0000000000045195","DOIUrl":"https://doi.org/10.1097/MD.0000000000045195","url":null,"abstract":"<p><p>The potential links between psychiatric disorders and cancer risk have attracted significant attention in recent years. However, the causal relationships between these conditions remain unclear. To assess causality, a Mendelian randomization analysis was conducted using single nucleotide polymorphisms from large-scale European genome-wide association studies (GWAS). The inverse variance weighted (IVW) method was applied as the primary method for causal estimation, with additional sensitivity analyses performed to evaluate potential pleiotropic effects. IVW estimates revealed that bipolar disorder was associated with an increased risk of prostate cancer (odds ratio (OR) = 1.07; 95% confidence interval (CI): 1.003-1.15; P = .04). Genetically predicted depression was causally linked to a significantly higher risk of breast cancer (OR = 2.49; 95% CI: 1.26-4.9; P = .008), particularly in estrogen receptor-positive (ER+) breast cancer (OR = 2.82; 95% CI: 1.17-6.81; P = .02). Schizophrenia was associated with a significantly higher risk of multiple cancer types, including lung cancer (OR = 1.16; 95% CI: 1.03-1.3; P = .01), breast cancer (OR = 1.05; 95% CI: 1.02-1.09; P = .002), ER+ breast cancer (OR = 1.06; 95% CI: 1.02-1.09; P = .002), endometrial cancer (OR = 1.05; 95% CI: 1.002-1.1; P = .04), and ovarian cancer (OR = 1.08; 95% CI: 1.03-1.13; P = .0007). No significant pleiotropy of the instrumental variables was observed. This psycho-oncology study, characterized by minimal pleiotropic effects, provides genetic evidence supporting an increased incidence of various cancers associated with psychiatric disorders. These findings suggest that underlying psychiatric processes may contribute to cancer development.</p>","PeriodicalId":18549,"journal":{"name":"Medicine","volume":"104 41","pages":"e45195"},"PeriodicalIF":1.4,"publicationDate":"2025-10-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145292859","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}