Medicine最新文献

{"title":"Effect of Danggui Buxue Medicinal Diet on cancer-related fatigue in anemic colon cancer patients undergoing chemotherapy: A randomized controlled trial (CONSORT-compliant).","authors":"Ligang Wang, Liu Yang, Long Wang, Xiaoqin Liang, Yajiao Wang, Bichun Huang, Xia Sheng, Guijiao Lin, Jian Du, Aijun You","doi":"10.1097/MD.0000000000051072","DOIUrl":"https://doi.org/10.1097/MD.0000000000051072","url":null,"abstract":"<p><strong>Background: </strong>Cancer-related fatigue (CRF) is one of the most common and distressing symptoms experienced by patients undergoing chemotherapy, and no gold standard for the treatment of CRF has been established. This study aimed to evaluate the effects of the Danggui Buxue Medicinal Diet on CRF in patients with chemotherapy-induced anemia following colon cancer surgery.</p><p><strong>Methods: </strong>A total of 96 patients admitted to the intestinal surgery ward and daytime chemotherapy ward of a tertiary hospital from May 2021 to December 2022 who met the inclusion criteria were selected and randomly divided into 2 groups: 48 patients in the control group and 48 in the experimental group. The control group received standard treatment and nursing care for postoperative chemotherapy for colon cancer, while the experimental group followed the control group's regimen and additionally received the Danggui Buxue Medicinal Diet for 21 consecutive days. Fatigue levels, blood counts, and inflammatory factors were compared before and after the intervention in both groups.</p><p><strong>Results: </strong>A total of 86 patients completed the study. After the intervention, the CRF scores in the experimental group were significantly lower than those in the control group (29.14 ± 2.58 vs 44.02 ± 4.25), with a between-group mean difference of -14.88 (95% confidence interval [CI], -16.38 to -13.38; P < .001). Hemoglobin levels were significantly higher in the experimental group than in the control group (115.26 ± 11.72 vs 106.52 ± 12.93), with a mean difference of 8.74 (95% CI, 3.45-14.03; P < .001). Red blood cell counts were also higher in the experimental group (mean difference 0.61; 95% CI, 0.44-0.78; P < .001). In addition, levels of inflammatory factors were significantly reduced, with interleukin-6 showing a mean difference of -16.28 (95% CI, -20.10 to -12.46; P < .001) and tumor necrosis factor-α showing a mean difference of -26.09 (95% CI, -29.80 to -22.38; P < .001).</p><p><strong>Conclusion: </strong>The Danggui Buxue Medicinal Diet was associated with improvements in CRF, hematological parameters, and inflammatory markers in patients with chemotherapy-induced anemia following colon cancer surgery. These findings suggest that it may have potential as a supportive nutritional intervention for managing CRF in this population.</p>","PeriodicalId":18549,"journal":{"name":"Medicine","volume":"105 43","pages":"e51072"},"PeriodicalIF":2.0,"publicationDate":"2026-10-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149270392","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Research trends and hotspot analysis of sudden cardiac death in hypertrophic cardiomyopathy: A bibliometric analysis.","authors":"Zhen Chen, Fen Ai, Jinlei Li, Yu Li","doi":"10.1097/MD.0000000000051272","DOIUrl":"https://doi.org/10.1097/MD.0000000000051272","url":null,"abstract":"<p><strong>Background: </strong>Hypertrophic cardiomyopathy is the most common genetic heart disease and a leading cause of sudden cardiac death. This study aims to map the research landscape of Hypertrophic cardiomyopathy -related sudden cardiac death over the past 2 decades using bibliometric methods.</p><p><strong>Methods: </strong>We performed a bibliometric analysis of 712 publications retrieved from the Web of Science Core Collection (2005-2025). Using Cite Space, we examined publication trends, collaboration networks, co-citation patterns, and keyword dynamics.</p><p><strong>Results: </strong>Annual publication output rose markedly, with pronounced accelerations after the 2014 European Society of Cardiology and 2020 American heart association/American College of Cardiology guidelines. The United States led in productivity (203 publications) and network centrality (0.40), while China ranked second in output (123 publications) but exhibited limited international collaboration (centrality = 0.01). Co‑citation analysis indicated that clinical guidelines and risk‑prediction models form the field' score knowledge base, and five of the ten most cited references were international guidelines. Keyword analysis defined 4 principal thematic clusters disease entity, clinical outcomes, imaging biomarkers, and risk stratification and documented a shift from early mechanistic studies to multimodal risk prediction, followed more recently by artificial intelligence-driven models and targeted pharmacological therapies (e.g., mavacamten).</p><p><strong>Conclusion: </strong>This study provides a systematic, data-driven overview of the knowledge structure and evolutionary trends in Hypertrophic cardiomyopathy-related sudden Cardiac death research. The findings underscore the field' s guideline-driven character, document the rise of AI-based risk stratification, and describe a paradigm shift toward disease-modifying therapies, offering actionable insights for prioritizing future research and informing clinical decision-making.</p>","PeriodicalId":18549,"journal":{"name":"Medicine","volume":"105 43","pages":"e51272"},"PeriodicalIF":2.0,"publicationDate":"2026-10-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149270442","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Advance care planning communication training workshop for professional care workers in Japan: A mixed-method approach.","authors":"Hiroko Ohashi, Yoshihisa Hirakawa, Keiko Abe, Hideaki Andoh, Tsukasa Muraya, Yuito Hosaka, Young Jae Hong, Chifa Chiang, Hiroshi Yatsuya","doi":"10.1097/MD.0000000000051208","DOIUrl":"https://doi.org/10.1097/MD.0000000000051208","url":null,"abstract":"<p><p>Advance care planning (ACP) is a process of communication between individuals and care teams. ACP enables individuals to make informed decisions regarding their future healthcare and support when their capacity to express or discuss personal choices becomes restricted. In this study, we aimed to develop and implement an ACP educational program for Japanese professional care workers and describe changes in their attitudes and practices post-implementation. We developed an ACP educational program. Eighty-two professional care workers from 5 prefectures participated from January to September 2019. We conducted pre- and post-tests, post-program interviews, and written interviews 3 months post-program. Changes in knowledge and attitudes were statistically analyzed, and interviews were analyzed using qualitative content analysis. The program helped participants improve their knowledge of substitute decision-making by families, withdrawal of tube feeding, and living wills. Participants experienced reduced difficulty in caring for dying patients. The qualitative analysis of post-program interviews identified the following 7 themes: foundational knowledge of ACP, attentive interviewing, inferring clients' preferences from informal conversation, rapport-building, consensus-building among stakeholders, merits of initiating ACP discussions by professional care workers, and skill in explaining the concept of a living will. The written interviews conducted after 3 months identified the following 4 themes: discussion opportunities, discussion skills, self-determination and substitute decision-making, and thinking about death as a personal matter. These qualitative analyses reinforced and explained the quantitative survey results. The ACP educational program presented herein helps improve the education of professional care workers and disseminates ACP.</p>","PeriodicalId":18549,"journal":{"name":"Medicine","volume":"105 43","pages":"e51208"},"PeriodicalIF":2.0,"publicationDate":"2026-10-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149270203","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Bidirectional Mendelian randomization analysis reveals the causal relationship between rheumatoid arthritis and acute sinusitis.","authors":"Rui Hu, Yunwang Zhang, Yi Zeng, Keqiu Dong, Zhongyun Li, Jianping Tao","doi":"10.1097/MD.0000000000051244","DOIUrl":"https://doi.org/10.1097/MD.0000000000051244","url":null,"abstract":"<p><p>This study explored the causal relationship between RA and acute sinusitis (AS) using a bidirectional Mendelian randomization (two-sample Mendelian randomization) analysis. We used publicly available genome-wide association study datasets to identify the single nucleotide polymorphisms associated with both RA and AS. We then applied statistical methods, including inverse variance weighting, MR-Egger regression, and weighted medians, to assess the causal effects between the 2 diseases. This study provides evidence through two-sample Mendelian randomization analysis, suggesting that RA may be an independent risk factor for AS. This highlights the role of immune modulation in the genetic overlap between The and AS, offering new perspectives for future research on immune disease mechanisms, and potential clinical prevention and treatment strategies.</p>","PeriodicalId":18549,"journal":{"name":"Medicine","volume":"105 43","pages":"e51244"},"PeriodicalIF":2.0,"publicationDate":"2026-10-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149270230","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Bing-Neel syndrome successfully treated with venetoclax and zanubrutinib: A case report and review of the literature.","authors":"Shenhe Jin, Yuhui Wu, Jin Zhang","doi":"10.1097/MD.0000000000051158","DOIUrl":"https://doi.org/10.1097/MD.0000000000051158","url":null,"abstract":"<p><strong>Rationale: </strong>Bing-Neel syndrome (BNS) is an uncommon neurological manifestation of Waldenström's Macroglobulinemia (WM). The diagnosis of BNS is still challenging due to its low incidence and high heterogeneity. A definite diagnosis relies on histopathology and cerebrospinal fluid (CSF) analysis to identify lymphoplasmacytic lymphocyte infiltration of the central nervous system. MYD88 L265P mutation also serves as a valuable diagnostic tool. To date, there is no consensus on the standard management of BNS, and current evidence is largely limited to reports on the use of high-dose chemotherapy and BTK inhibitors. Herein, we present a case of BNS who achieved remission following treatment with venetoclax and zanubrutinib. Furthermore, venetoclax was detected in CSF.</p><p><strong>Patient concern: </strong>A 66-year-old female with WM presenting with a headache.</p><p><strong>Diagnoses: </strong>Bing-Neel syndrome.</p><p><strong>Interventions: </strong>The patient was diagnosed with BNS through CSF examination and treated with zanubrutinib plus venetoclax.</p><p><strong>Outcomes: </strong>The patient's symptoms resolved, and abnormal B lymphocytes were not detected in CSF.</p><p><strong>Lesson: </strong>BNS is an uncommon manifestation of WM, with significant diagnostic challenges. In the absence of standard management for BNS, high-dose chemotherapy and BTK inhibitors are widely used as front-line approaches. BCL-2 inhibitors, which have shown notable CNS-penetrating capacity, hold considerable promise for the treatment of BNS and merit further exploration.</p>","PeriodicalId":18549,"journal":{"name":"Medicine","volume":"105 43","pages":"e51158"},"PeriodicalIF":2.0,"publicationDate":"2026-10-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149270238","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Baseline miR-10a, miR-146a, and miR-155 expression and subsequent clinical and radiological outcomes in multiple sclerosis: A retrospective observational study.","authors":"Furkan Sarıdaş, Havva Tezcan Ünlü, Gülşah Çeçener, Özlem Taşkapılıoğlu, Ömer Faruk Turan","doi":"10.1097/MD.0000000000051116","DOIUrl":"https://doi.org/10.1097/MD.0000000000051116","url":null,"abstract":"<p><p>Multiple sclerosis (MS) is a chronic, immune-mediated central nervous system disorder with a multifactorial etiology, driven by genetic-environmental interplay. MicroRNAs (miRNAs), small non-coding RNAs, act as key post-transcriptional regulators within epigenetic mechanisms, integrating these determinants into gene expression networks. Increasing evidence implicates miRNA dysregulation as an important contributor to MS pathogenesis and progression. Between 2015 and 2018, expression levels of miR-10a, miR-146a, and miR-155 were obtained from whole blood samples of patients with MS using RT-PCR and evaluated to investigate associations between baseline miRNA expression patterns and subsequent clinical and radiological outcomes. Based on these data, the medical records of 54 patients who remained under follow-up (2015-2023) were reviewed retrospectively. Following expression analysis, the number of relapses, annualized relapse rate, changes in Expanded Disability Status Scale (EDSS) score, radiological activity, and achievement of No Evidence of Disease Activity (NEDA-3) status were assessed over a mean follow-up period of approximately 5 years. A total of 54 patients (40 female and 14 male) were included. The mean follow-up period was 62.44 ± 21.14 months (14-81 months). The median age at diagnosis was 31 years (16-53 years). Differences in miR-10a expression levels were found in 37 patients (68.5%), miR-146a in 36 (66.7%), and miR-155 in 41 (75.9%). miR-10a dysregulation was significantly associated with the final EDSS score (P = .007) and the presence of cervical spinal cord lesions at baseline (P = .040). miR-146a and miR-155 dysregulation were significantly associated with the development of new cervical spinal cord lesions (P = .020 and P = .025, respectively). miR-155 also showed a nominal association with overall radiological activity (P = .049). Exploratory ROC analysis showed limited discriminatory performance of miR-155 for radiological activity (AUC = 0.655, 95% CI: 0.513-0.779; P = .0387). In this exploratory retrospective study, baseline expression patterns of miR-10a, miR-146a, and miR-155 were associated with selected subsequent clinical and radiological outcomes in patients with MS. Associations were observed between miR-10a and disability measures, between miR-146a/miR-155 and new cervical spinal cord lesions, and between miR-155 and radiological activity. These findings should be considered hypothesis-generating and require confirmation in larger prospective studies with longitudinal miRNA assessment and independent validation.</p>","PeriodicalId":18549,"journal":{"name":"Medicine","volume":"105 43","pages":"e51116"},"PeriodicalIF":2.0,"publicationDate":"2026-10-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149270253","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Depression and associated factors among women of childbearing age: A cross-sectional study based on the health ecology model.","authors":"Haoyu Liu, Fei Wang, Baokai Gao, Xiaoyu Li, Shuo Xu, Chenxi Gao, Wenlong Wang","doi":"10.1097/MD.0000000000051270","DOIUrl":"https://doi.org/10.1097/MD.0000000000051270","url":null,"abstract":"<p><p>Depression among women of childbearing age (WCBA) is influenced not only by physiological mechanisms but also by complex social and environmental determinants, highlighting the need for a comprehensive, multilevel analytical framework. Using data from the China Family Panel Studies 2022, 5884 WCBA were included in the study. Based on the health ecology model, univariate and survey-weighted binary logistic regression analyses were conducted, and robustness was assessed using survey-weighted multiple linear regression. According to 2022 China Family Panel Studies data, the prevalence of depression among WCBA was 30.68%. In the fully adjusted survey-weighted logistic regression model, older age and higher subjective well-being were associated with lower odds of depression. Compared with participants who reported excellent self-assessed health, those reporting good, fair, and poor health had higher odds of depression. Compared with participants who were illiterate, those with primary school, junior high school, senior high school, and college or above education had lower odds of depression. Exercise was also associated with lower odds of depression. The findings were generally consistent in the robustness analysis using survey-weighted multiple linear regression. Depression among WCBA was associated with factors across multiple levels of the health ecology model, particularly individual characteristics, health-related behaviors, and psychosocial resources. This findings suggests that multilevel comprehensive intervention strategies should be adopted to more effectively prevent the onset of depression.</p>","PeriodicalId":18549,"journal":{"name":"Medicine","volume":"105 43","pages":"e51270"},"PeriodicalIF":2.0,"publicationDate":"2026-10-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149270284","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Heterogeneity in nerve recovery patterns despite symptomatic improvement in paclitaxel-induced neuropathy: A longitudinal analysis.","authors":"Ikhyun Lim, Yong Wha Moon, MiRi Suh, Seul-Gi Kim","doi":"10.1097/MD.0000000000051151","DOIUrl":"https://doi.org/10.1097/MD.0000000000051151","url":null,"abstract":"<p><p>Chemotherapy-induced peripheral neuropathy (CIPN) is a common and potentially persistent toxicity of paclitaxel. This prospective study aimed to characterize longitudinal changes in paclitaxel-induced CIPN by integrating serial neurophysiological and clinical assessments. Twenty-six patients receiving paclitaxel-based chemotherapy for breast, ovarian, or endometrial cancer were prospectively enrolled. Assessments were scheduled at baseline (T0), completion of chemotherapy (T1), 3 months posttreatment (T2), and 1 year posttreatment (T3) and included nerve conduction studies (NCS), the self-reported Leeds Assessment of Neuropathic Symptoms and Signs (S-LANSS), and Common Terminology Criteria for Adverse Events (CTCAE) grading. Fourteen patients with available longitudinal outcome data were included in the analytic cohort. Longitudinal changes were analyzed using linear mixed-effects models, and associations between NCS parameters and clinical measures were explored using repeated-measures correlation. S-LANSS scores increased from 1.29 ± 4.81 at T0 to 14.29 ± 4.23 at T1 and subsequently decreased to 4.86 ± 5.88 at T3 (overall P < .001), although they remained higher than baseline (P = .008). NCS amplitudes showed heterogeneous recovery patterns. Sural SNAP amplitude markedly decreased at T1 but recovered thereafter and was not significantly different from baseline at T3. In contrast, ulnar SNAP amplitude remained significantly reduced at T3 (P < .001), whereas tibial compound motor action potential amplitude was no longer significantly different from baseline (P = .060). NCS amplitudes were inversely associated with clinical measures, with the strongest association observed between ulnar SNAP amplitude and CTCAE grade (r = -0.720, P < .001). Paclitaxel-induced peripheral neuropathy showed substantial symptomatic improvement after chemotherapy but heterogeneous electrophysiological recovery across peripheral nerves. Persistent abnormalities in selected nerves despite symptom improvement highlight the complementary roles of patient-reported outcomes and objective neurophysiological assessment in characterizing the longitudinal course of CIPN.</p>","PeriodicalId":18549,"journal":{"name":"Medicine","volume":"105 43","pages":"e51151"},"PeriodicalIF":2.0,"publicationDate":"2026-10-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149270345","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Quality and reliability of sarcopenia-related short videos on Douyin: A cross-sectional content analysis.","authors":"Ting Zhang, Jiabei Wu, Jinli Guo","doi":"10.1097/MD.0000000000051258","DOIUrl":"https://doi.org/10.1097/MD.0000000000051258","url":null,"abstract":"<p><p>Sarcopenia is a geriatric syndrome marked by the progressive decline in skeletal muscle mass, strength, and physical function. It typically develops insidiously and advances gradually, significantly increasing the risk of adverse outcomes such as falls, frailty, and mortality among older adults. With the rise of social media platforms like Douyin, the Chinese domestic counterpart of TikTok, for public health messaging, it is crucial to systematically evaluate the quality of content on this platform related to sarcopenia. In this cross-sectional content analysis, we collected Douyin videos related to sarcopenia using the platform's default ranking algorithm and, after applying inclusion and exclusion criteria, obtained 156 videos. For each video, we recorded user interaction metrics (likes, comments, shares, collections) and extracted associated metadata. We evaluated content quality with the Global Quality Scale (GQS), the modified DISCERN (mDISCERN), and the JAMA benchmark criteria. We conducted Spearman's correlation analyses to examine correlations among video variables, GQS, mDISCERN, and the JAMA score. The majority of the content originated from medical professionals (43.6%), with a primary focus on disease overviews (34.6%). Video quality assessments indicated low overall standards: GQS scores frequently reached 3 (44.9%), mDISCERN scores predominantly reached 2 (42.9%), and JAMA scores were concentrated at 2 (55.1%). Videos created by general users scored significantly lower than those from other sources (all P < .05). Furthermore, video duration was positively correlated with GQS (r = 0.470, P < .001) and mDISCERN scores (r = 0.363, P < .001), but not with JAMA scores (r = 0.166, P = .691). In contrast, no significant correlations emerged between quality and interaction metrics. While Douyin has the potential to raise awareness about sarcopenia, the prevalence of subpar content highlights the need for stronger oversight, credential verification, and better algorithmic prioritization to improve the quality of health information on the platform.</p>","PeriodicalId":18549,"journal":{"name":"Medicine","volume":"105 43","pages":"e51258"},"PeriodicalIF":2.0,"publicationDate":"2026-10-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149270370","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Primary renal diffuse large B cell lymphoma misdiagnosed as renal cell carcinoma: A case report.","authors":"Xintong Li, Jia Li, Shijie Sun, Pintong Huang","doi":"10.1097/MD.0000000000051228","DOIUrl":"https://doi.org/10.1097/MD.0000000000051228","url":null,"abstract":"<p><strong>Rationale: </strong>Primary renal lymphoma (PRL) is a rare malignant lymphoma characterized by an extranodal presentation with limited or absent involvement of lymphatic channels. Its nonspecific clinical manifestations often make differentiation from renal cell carcinoma (RCC) challenging. This report describes a case of non-Hodgkin lymphoma initially diagnosed as RCC and subsequently confirmed as primary diffuse large B-cell lymphoma (DLBCL).</p><p><strong>Patient concerns: </strong>A 78-year-old man presented with right flank pain radiating to the abdomen for 2 weeks. Physical examination revealed no significant abnormalities.</p><p><strong>Diagnoses: </strong>Laboratory tests showed a mild elevation of lactate dehydrogenase (LDH) and positive urine occult blood. Imaging evaluations, including ultrasonography, computed tomography (CT), and magnetic resonance imaging (MRI), were suggestive of RCC. Contrast-enhanced ultrasonography further supported this initial impression.</p><p><strong>Interventions: </strong>Based on the suspicion of RCC, an ultrasound-guided renal needle biopsy was performed to establish the diagnosis.</p><p><strong>Outcomes: </strong>Histological Pathology: Histopathological analysis of the ultrasound-guided biopsy confirmed primary renal DLBCL.</p><p><strong>Lessons: </strong>This case underscores the importance of accurate diagnostic methods in oncology, particularly in distinguishing PRL from RCC, which can be challenging based on imaging alone. The findings demonstrate the utility of ultrasound-guided biopsy as a reliable diagnostic tool for primary renal lymphoma.</p>","PeriodicalId":18549,"journal":{"name":"Medicine","volume":"105 43","pages":"e51228"},"PeriodicalIF":2.0,"publicationDate":"2026-10-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149270423","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}