Medicine最新文献

{"title":"Clinical importance of the relationship between parietal foramen variations and the sagittal suture.","authors":"Nazire Kilic Safak, Zekiye Karaca Bozdag, Ayca Pamukcu, Ozkan Oguz","doi":"10.1097/MD.0000000000042075","DOIUrl":"10.1097/MD.0000000000042075","url":null,"abstract":"<p><p>This study aims to determine the prevalence, number, and localization of the parietal foramen in relation to the sagittal suture. Forty skulls (80 parietal bones), whose age and sex were unknown, from the Department of Anatomy, Faculty of Medicine, Cukurova University, were studied. Morphometric measurements were performed using a digital caliper. The presence of the parietal foramen and its number, localization, and distance from the sagittal suture were evaluated in this study. SPSS v.20 software was used for statistical analysis. In addition to descriptive statistical methods, the Mann-Whitney U-test was used to evaluate the quantitative data. The parietal foramen was not detected in 19 skulls (47.5%) but was observed unilaterally in 10 skulls (25%) and bilaterally in 11 skulls (27.5%). The parietal foramen was detected in 32 parietal bones (40%). Furthermore, it was observed as single in 30 parietal bones (37.5%) and as double in 2 parietal bones (2.5%); however, the triple parietal foramen was not detected. There were no double foramens in the right parietal bone. The foramen was not observed in 48 (60%) of the parietal bones. The mean distance between the parietal foramen and sagittal suture was as 7.42 ± 5.64 mm. No statistically significant differences were detected between the parietal foramina in terms of their distances to the sagittal suture on either the right or left side (P > .05). Knowledge of the localization of the parietal foramen and its relationship with the sagittal suture helps understand the relationship between the dural venous sinuses and scalp veins. Furthermore, an understanding of these variations may aid in the detection of congenital anomalies. We believe that the results of this study will contribute important morphometric data for anatomists and clinicians.</p>","PeriodicalId":18549,"journal":{"name":"Medicine","volume":"104 14","pages":"e42075"},"PeriodicalIF":1.3,"publicationDate":"2025-04-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143803884","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparison of direct anterior versus posterolateral approach total hip arthroplasty for developmental dysplasia of the hip: A clinical effectiveness retrospective study.","authors":"Wuyuanhao Lin","doi":"10.1097/MD.0000000000042024","DOIUrl":"10.1097/MD.0000000000042024","url":null,"abstract":"<p><p>The aim of this study was to evaluate the clinical efficacy of 2 approaches to total hip arthroplasty-the direct anterior approach and the posterolateral approach-in the treatment of developmental dysplasia of the hip. A total of 201 patients who were hospitalized between 2018 and 2023 for this condition were included in the study. Of the total number of patients, 100 underwent the procedure via the direct anterior approach (study group), whereas 101 underwent total hip arthroplasty via the posterolateral approach (control group). A range of clinical and patient data was gathered, including the following: age, gender, body mass index, disease classification, symptom history, intraoperative blood loss, blood transfusion volume, incision length, operation time, hospital stay, visual analog scale score, Harris score, Barthel index, postoperative complications, follow-up time, leg length discrepancy, and femur offset difference. The lack of statistically significant variations in age, gender, body mass index, and symptom history among the 2 patient groups suggests that they were comparable. Nevertheless, notable disparities were observed between the groups with regard to the length of the surgical incision (P < .001) and intraoperative blood loss (P < .001). Significant differences (P < .001) were observed in the visual analog scale scores of the patients in the study group at 1 day (6.71 ± 0.46), 3 days (5.71 ± 0.46), and 1 week (0.96 ± 0.20) after surgery, in comparison with the control group (7.46 ± 0.51, 6.35 ± 0.49, 1.73 ± 0.67). In addition, notable distinctions were detected in the Harris score between the groups at the Harris score 3 months postsurgery (P < .001) and at the last follow-up (P = .012). Furthermore, noteworthy distinctions were observed in the study group regarding both preoperative and postoperative leg length discrepancy (P < .001), in addition to preoperative offset and postoperative offset (P < .001). The utilization of the direct anterior approach in total hip replacement presents several advantages, including reduced tissue damage, decreased pain, quicker postoperative functional recovery, reduced dislocation risk, and enhanced hip joint functionality. This approach is in accordance with the tenets of minimally invasive surgery and improved recovery protocols, rendering it a feasible option for the management of developmental dysplasia of the hip among individuals.</p>","PeriodicalId":18549,"journal":{"name":"Medicine","volume":"104 14","pages":"e42024"},"PeriodicalIF":1.3,"publicationDate":"2025-04-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143803888","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evaluation of primary physicians' awareness levels of non-ossifying fibromas and fibrous cortical defects by using referral documents.","authors":"Manabu Hoshi, Yoshitaka Ban, Naoto Oebisu, Tadashi Iwai, Naoki Takada, Masanari Aono","doi":"10.1097/MD.0000000000041754","DOIUrl":"10.1097/MD.0000000000041754","url":null,"abstract":"<p><p>This study aimed to investigate the awareness levels of primary physicians regarding non-ossifying fibromas (NOFs)/fibrous cortical defects (FCDs) using patient referral documents. Referral documents of 62 male and 46 female patients (mean age: 11 [5-32] years) who were diagnosed with NOFs/FCDs based on radiological findings were retrospectively reviewed. The suspected diagnoses by primary physicians were classified as \"NOF/FCD,\" \"Benign,\" \"Intermediate,\" \"Malignant,\" and \"No description.\" The Ritschl radiological classification of NOFs/FCDs and the relationship between the stages and suspected diagnoses were examined. NOFs/FCDs were diagnosed in 40 patients. The classifications were \"Benign,\" \"Intermediate,\" \"Malignant,\" and \"No description'' in 12, 3, 5, and 48 patients. Osteosarcoma was suspected in 4 patients. Among 63 patients with stage A Ritschl classification, NOFs/FCDs were diagnosed in 24 and osteosarcoma was suspected in 3. In 30 patients with stage B, NOFs/FCDs were diagnosed in 11 and osteosarcoma was suspected in one. Among patients with stages C and D, 3/10 and 2/5 patients, respectively, were diagnosed with NOFs/FCDs and a malignant bone tumor was suspected in 1 case with stage D. The suspected diagnosis was ``No description'' in 46%, 43.3%, 40%, and 40% of patients with stages A, B, C, and D, respectively. The ``primary physicians\" awareness levels of NOF/FCD seemed insufficient, owing to a high rate of \"No description.\" Plain radiography is a diagnostic technique for NOFs/FCDs, and NOF/FCD lesions commonly develop in children and young adults. Primary physicians need to be educated about the typical NOF/FCD radiological findings.</p>","PeriodicalId":18549,"journal":{"name":"Medicine","volume":"104 14","pages":"e41754"},"PeriodicalIF":1.3,"publicationDate":"2025-04-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143803438","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Severe pneumomediastinum in an infant with respiratory syncytial virus infection: A case report.","authors":"Junji Egawa, Makiko Konda, Yusuke Naito, Taichi Kotani, Shota Sonobe, Masahiko Kawawguchi","doi":"10.1097/MD.0000000000042038","DOIUrl":"10.1097/MD.0000000000042038","url":null,"abstract":"<p><strong>Rationale: </strong>The respiratory syncytial virus (RSV) is an important cause of bronchiolitis in children, with limited reports of pneumomediastinum as a complication. We report an infant with pneumomediastinum associated with RSV infection requiring intubation.</p><p><strong>Patient concerns: </strong>A 4-month-old male infant was diagnosed with RSV infection on the 2nd day of symptom onset (coughing and fever). On the 7th day of symptom onset, chest radiography and computed tomography revealed severe pneumomediastinum, and thus, he was transferred to the intensive care unit.</p><p><strong>Diagnosis: </strong>Severe pneumomediastinum secondary to RSV infection.</p><p><strong>Interventions: </strong>The patient was intubated, and lung-protective ventilation with muscle relaxants was initiated. After 42 hours of continuous muscle relaxant administration, weaning from mechanical ventilation was started. He was extubated after confirming improved oxygenation and favorable imaging findings.</p><p><strong>Outcomes: </strong>The infant recovered completely without further worsening of pneumomediastinum.</p><p><strong>Lessons: </strong>An infant with severe pneumomediastinum requiring intubation during the course of RSV infection was successfully managed with lung-protective ventilation using muscle relaxants.</p>","PeriodicalId":18549,"journal":{"name":"Medicine","volume":"104 14","pages":"e42038"},"PeriodicalIF":1.3,"publicationDate":"2025-04-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143803820","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association between microRNA-451a expression in serum and survival and prognosis in patients with Hodgkin's lymphoma.","authors":"Fuying Huo, Qi Zhang, Chunhuan Hu, Fangyuan Chai","doi":"10.1097/MD.0000000000032587","DOIUrl":"10.1097/MD.0000000000032587","url":null,"abstract":"<p><strong>Background: </strong>MicroRNA-451a (miR-451a) is associated with the treatment response and outcomes in patients with Hodgkin lymphoma. The present study aimed to investigate the expression of miR-451a in patients with Hodgkin's lymphoma, and to analyze its association with survival and prognosis in clinical patients.</p><p><strong>Methods: </strong>A total of 164 patients with Hodgkin's lymphoma and 164 healthy controls (control group) were enrolled in this study. Blood samples were collected from participants and expression levels of miR-451a were detected using reverse transcription quantitative polymerase chain reaction. Multivariate Cox-regression analysis was used to analyze the association between serum level of miR-451a and overall survival, as well as prognosis of Hodgkin's lymphoma patients. Kaplan-Meier curve was used to analyze the five-year recurrence.</p><p><strong>Results: </strong>Outcomes demonstrated that Hodgkin's lymphoma patients had lower miR-451a serum level than healthy controls. The present results showed that expression of miR-451a was higher in the group where chemotherapy was effective than that patient where chemotherapy was ineffective. High serum levels of miR-451a were associated with longer overall survival and better prognosis of Hodgkin's lymphoma patients than patients who had lower serum miR-451a levels. Multivariate Cox-regression analysis identified miR-451a serum level was positively correlated with overall survival and prognosis in patients with Hodgkin's lymphoma.</p><p><strong>Conclusion: </strong>The results of the present study demonstrate that serum levels of miR-451a is decreased in patients with Hodgkin's lymphoma. Data indicate that serum levels of miR-451a can be used as one of the potential biomarkers and prognosis for patients with Hodgkin's lymphoma.</p>","PeriodicalId":18549,"journal":{"name":"Medicine","volume":"104 14","pages":"e32587"},"PeriodicalIF":1.3,"publicationDate":"2025-04-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143803871","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Mediating role of ethical sensitivity in the relationship between empathy and professional values among nursing master's students in China: A cross-sectional study.","authors":"Shujun Fan, Yujing Gu, Jun Xie, Minlie Yang","doi":"10.1097/MD.0000000000042077","DOIUrl":"10.1097/MD.0000000000042077","url":null,"abstract":"<p><p>In the evolving landscape of nursing education in China, where only 0.2% of clinical nurses hold master's degrees, upholding professional values among nursing students is crucial in ensuring good patient, nurse, and organization outcomes. Empathy and ethical sensitivity are pivotal in shaping professional values, affecting decision-making, stress management, and nurse-patient relationships. Yet, the underlying mechanisms of empathy and ethical sensitivity in enhancing professional values among nursing master's students remain underexplored. This cross-sectional study aims to test and compare 2 mediation models with empathy and ethical sensitivity as mediators in affecting professional values among nursing master's students in China. From September to October 2023, 236 nursing master's students were selected from a university in Jiangsu Province, China, using convenience sampling. The students' empathy, ethical sensitivity, and professional values were assessed using the Jefferson Scale of Physician Empathy-Nursing Student (JSPE-NS), the Ethical Sensitivity Questionnaire for Nursing Students (ESQ-NS), and the Nursing Professional Values Scale (NPVS), respectively. Multivariate linear regression analyses were used to assess the effects of empathy and ethical sensitivity on professional values. The mediation models were examined via bootstrapping techniques using SPSS PROCESS v.4.3 macros (Model 4). Findings revealed that the mean scores for empathy, ethical sensitivity, and professional values among nursing master's students were 104.64 ± 17.28, 39.43 ± 7.71, and 97.99 ± 18.69, respectively. Both empathy (β = 0.385, P < .001) and ethical sensitivity (β = 0.371, P < .001) were independently associated with professional values. Both medication models were statistically significant, and we chose the model that aligns better with established nursing theory and practice: ethical sensitivity partially mediated the relationship between empathy and professional values. The level of professional values among nursing master's students is moderate. Additionally, ethical sensitivity plays a partial mediating role in the relationship between empathy and professional values. Therefore, enhancing ethical education to improve the ethical sensitivity and empathy of nursing master's students is essential for fostering the establishment of appropriate professional values.</p>","PeriodicalId":18549,"journal":{"name":"Medicine","volume":"104 14","pages":"e42077"},"PeriodicalIF":1.3,"publicationDate":"2025-04-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143803694","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Screening and identification analysis of core markers for leukemia and cervical cancer: Calmodulin 3 as a core target.","authors":"Danfeng Shao, Huaiying Yu, Xiaoqing Zhu","doi":"10.1097/MD.0000000000041665","DOIUrl":"10.1097/MD.0000000000041665","url":null,"abstract":"<p><p>Leukemia is a type of malignant tumor affecting hematopoietic system. Cervical cancer is a malignant tumor of female reproductive tract. The relationship between Calmodulin 3 (CALM3) and leukemia, cervical cancer remains unclear. Leukemia dataset GSE26294 and cervical cancer dataset GSE173097 profiles were downloaded from gene expression omnibus. Principal component analysis, differentially expressed genes (DEGs) screening, weighted gene co-expression network analysis (WGCNA), functional enrichment analysis, gene set enrichment analysis, immune infiltration analysis, protein-protein interaction network construction and analysis, survival analysis were performed. Gene expression heatmaps were plotted. Comparative Toxicogenomics Database (CTD) was used to find diseases most related to core genes. 77 DEGs were identified. According to gene ontology, in biological process category, they were mainly enriched in cell proliferation, immune response, and apoptotic process. In cellular component category, they were mainly enriched in nucleus and Golgi apparatus. In molecular function category, they were mainly enriched in DNA binding, protein binding, transcription factor activity. In Kyoto encyclopedia of gene and genome analysis, they were mainly enriched in cell adhesion molecules, Wnt signaling pathway, cAMP signaling pathway, cGMP-PKG signaling pathway, and basal cell carcinoma. The soft-threshold power in WGCNA was set to 1, generating 6 modules. Finally identifying 3 core genes (CALM3, secreted frizzled-related protein 4, plasminogen). CTD analysis revealed that core genes were related to leukemia, coagulation disorders, vaginal tumors, cervical tumors, autoimmune diseases, and inflammation. CALM3 is lowly expressed in leukemia samples and highly expressed in cervical cancer samples.</p>","PeriodicalId":18549,"journal":{"name":"Medicine","volume":"104 14","pages":"e41665"},"PeriodicalIF":1.3,"publicationDate":"2025-04-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143803767","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Analyzing the causal relationship between gut microbiotas, blood metabolites, and COVID-19 susceptibility: A Mendelian randomization study.","authors":"Xiao-Yan Yao, Yan-Hua Zhang, Yu-Wei Weng, Jian-Feng Xie, Kui-Cheng Zheng","doi":"10.1097/MD.0000000000041445","DOIUrl":"10.1097/MD.0000000000041445","url":null,"abstract":"<p><p>Gut microbiota and blood metabolites play crucial roles in the progression and outcomes of COVID-19, but the causal relationships and mechanisms remain unclear. Our aim is to use two-sample Mendelian randomization (MR) to explore the causal relationships between gut microbiota, COVID-19 susceptibility, and potential mediating blood metabolites. We utilized summary statistics from the largest genome-wide association studies (GWAS) to date on gut microbiota (n = 18,340), blood metabolites (n = 115,078), and COVID-19 susceptibility (cases n = 60,176 and controls n = 1310,725 from the COVID-19 Host Genetics Initiative meta-analysis). We conducted bidirectional MR analyses to explore the causal relationships between gut microbiota and COVID-19 susceptibility and performed two-step MR to identify potential mediating blood metabolites. Five analytical methods were used to assess two-sample causal relationships, with inverse variance weighted (IVW) being the primary method. Sensitivity analyses were also conducted to ensure the robustness of the main MR results. Using the IVW method, we found causal relationships between 3 types of gut microbiota and 34 blood metabolites with COVID-19 susceptibility. In the two-step MR, the non-oxidative branch of the Pentose phosphate pathway was shown to reduce Sebacate (C10-DC) levels, and the species Parabacteroides goldsteinii was negatively correlated with Acetoacetate levels. Sebacate (C10-DC) levels were negatively associated with COVID-19 susceptibility, while Acetoacetate levels were positively associated with COVID-19 susceptibility. Furthermore, these causal relationships remained significant after correcting for false discovery rates (all q-values < 0.05). Heterogeneity and pleiotropy tests showed no statistical significance (P > .05). Mediation analysis indicated that the abundance of the non-oxidative branch of the Pentose phosphate pathway and COVID-19 susceptibility was mediated by Sebacate (C10-DC) levels (mediation proportion of 15.8%), and the abundance of P goldsteinii and COVID-19 susceptibility was mediated by Acetoacetate levels (mediation proportion of 31.7%). The current MR study provides evidence supporting the causal relationships between several specific gut microbiotas and COVID-19 susceptibility, as well as potential mediating blood metabolites. Our findings warrant further validation through larger epidemiological studies.</p>","PeriodicalId":18549,"journal":{"name":"Medicine","volume":"104 14","pages":"e41445"},"PeriodicalIF":1.3,"publicationDate":"2025-04-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143803842","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A case report of anti-AMPAR encephalitis with involuntary limb shaking and aphasia.","authors":"Shuang Li, Tiantian Huo, Minxia Geng, Jiahao Xing, Tianjun Wang","doi":"10.1097/MD.0000000000042036","DOIUrl":"10.1097/MD.0000000000042036","url":null,"abstract":"<p><strong>Rationale: </strong>Anti-alpha-amino-3-hydroxy-5-methyl-4-isozolipropionic acid receptor (AMPAR) encephalitis is a rare autoimmune encephalitis mediated by anti-AMPAR antibodies produced on the surface of neuronal cells. Anti-AMPAR encephalitis has a variety of clinical manifestations, the common clinical manifestations are characterized by borderline encephalitis, including short-term memory loss, confusion, behavioral abnormalities, and seizures.</p><p><strong>Patient concerns: </strong>Here we report a case of anti-AMPAR encephalitis in an adolescent female with aphasia as the first symptom of involuntary limb shaking.</p><p><strong>Diagnoses: </strong>The diagnosis of anti-AMPAR encephalitis is based on clinical symptoms and further detection of serum antibodies.</p><p><strong>Interventions and outcomes: </strong>The patient responded well to intravenous methylprednisolone combined with immunoglobulin treatment, and her limbs no longer shook and her speech was fluent.</p><p><strong>Lessons: </strong>Early diagnosis of autoimmune encephalitis is challenging due to the heterogeneity of clinical manifestations. Our patient was initially diagnosed with involuntary limb movement, so we should conduct further research on symptoms associated with autoimmune encephalitis.</p>","PeriodicalId":18549,"journal":{"name":"Medicine","volume":"104 14","pages":"e42036"},"PeriodicalIF":1.3,"publicationDate":"2025-04-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143803728","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Predictive role of insulin resistance surrogates in gallstone disease.","authors":"Jia Liu, Zixuan Hu, Dele Bo, Xiaohui Zhang, Zuoyang Zhang, Xueqing Liu","doi":"10.1097/MD.0000000000041478","DOIUrl":"10.1097/MD.0000000000041478","url":null,"abstract":"<p><p>Several studies have confirmed the association between insulin resistance (IR) surrogates and the risk of cardiovascular disease. This study aimed to investigate the correlation between 4 IR surrogates: triglyceride-glucose index (TyG), triglyceride-glucose index with waist circumference (TyG-WC), triglyceride-glucose index with body mass index (TyG-BMI), and triglycerides/high-density lipoprotein cholesterol ratio, and the risk of gallstone disease. This retrospective cross-sectional study involved a total of 19,696 participants who were divided into gallstone and non-gallstone groups based on ultrasound findings. Biochemical parameters and ultrasound results were collected and statistically analyzed. Nonparametric U test, Chi-square test, and subgroup analysis were used to examine the differences in expression of the 4 IR surrogates between the 2 groups. Logistic regression models and receiver operating characteristic curves were employed to evaluate the relationships and predictive ability of the 4 surrogates for gallstone disease. The levels of the 4 surrogates of IR were significantly higher in individuals with gallstone disease (GSD) compared to those without GSD (P < .001). After adjusting for age, gender, and personal medical history, TyG-WC and TyG-BMI emerged as significant predictors of gallstones in both genders. The predictive ability of these IR surrogates was stronger for gallstone disease in females than in males. In females, the area under the curve for TyG-WC and TyG-BMI were 0.683 and 0.629, respectively, while for males, these values were 0.544 and 0.528. When age was included with TyG-WC and TyG-BMI to predict GSD, the area under the curve values increased to 0.734 and 0.733 for females, and 0.684 and 0.682 for males. The study found that TyG-WC and TyG-BMI were identified as independent risk factors for the prevalence of GSD. Additionally, combined with age, TyG-WC and TyG-BMI showed good predictive value for the prevalence of GSD in females.</p>","PeriodicalId":18549,"journal":{"name":"Medicine","volume":"104 14","pages":"e41478"},"PeriodicalIF":1.3,"publicationDate":"2025-04-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143803745","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}