{"title":"Association between microRNA-451a expression in serum and survival and prognosis in patients with Hodgkin's lymphoma.","authors":"Fuying Huo, Qi Zhang, Chunhuan Hu, Fangyuan Chai","doi":"10.1097/MD.0000000000032587","DOIUrl":null,"url":null,"abstract":"<p><strong>Background: </strong>MicroRNA-451a (miR-451a) is associated with the treatment response and outcomes in patients with Hodgkin lymphoma. The present study aimed to investigate the expression of miR-451a in patients with Hodgkin's lymphoma, and to analyze its association with survival and prognosis in clinical patients.</p><p><strong>Methods: </strong>A total of 164 patients with Hodgkin's lymphoma and 164 healthy controls (control group) were enrolled in this study. Blood samples were collected from participants and expression levels of miR-451a were detected using reverse transcription quantitative polymerase chain reaction. Multivariate Cox-regression analysis was used to analyze the association between serum level of miR-451a and overall survival, as well as prognosis of Hodgkin's lymphoma patients. Kaplan-Meier curve was used to analyze the five-year recurrence.</p><p><strong>Results: </strong>Outcomes demonstrated that Hodgkin's lymphoma patients had lower miR-451a serum level than healthy controls. The present results showed that expression of miR-451a was higher in the group where chemotherapy was effective than that patient where chemotherapy was ineffective. High serum levels of miR-451a were associated with longer overall survival and better prognosis of Hodgkin's lymphoma patients than patients who had lower serum miR-451a levels. Multivariate Cox-regression analysis identified miR-451a serum level was positively correlated with overall survival and prognosis in patients with Hodgkin's lymphoma.</p><p><strong>Conclusion: </strong>The results of the present study demonstrate that serum levels of miR-451a is decreased in patients with Hodgkin's lymphoma. Data indicate that serum levels of miR-451a can be used as one of the potential biomarkers and prognosis for patients with Hodgkin's lymphoma.</p>","PeriodicalId":18549,"journal":{"name":"Medicine","volume":"104 14","pages":"e32587"},"PeriodicalIF":1.3000,"publicationDate":"2025-04-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Medicine","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1097/MD.0000000000032587","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"MEDICINE, GENERAL & INTERNAL","Score":null,"Total":0}
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Abstract
Background: MicroRNA-451a (miR-451a) is associated with the treatment response and outcomes in patients with Hodgkin lymphoma. The present study aimed to investigate the expression of miR-451a in patients with Hodgkin's lymphoma, and to analyze its association with survival and prognosis in clinical patients.
Methods: A total of 164 patients with Hodgkin's lymphoma and 164 healthy controls (control group) were enrolled in this study. Blood samples were collected from participants and expression levels of miR-451a were detected using reverse transcription quantitative polymerase chain reaction. Multivariate Cox-regression analysis was used to analyze the association between serum level of miR-451a and overall survival, as well as prognosis of Hodgkin's lymphoma patients. Kaplan-Meier curve was used to analyze the five-year recurrence.
Results: Outcomes demonstrated that Hodgkin's lymphoma patients had lower miR-451a serum level than healthy controls. The present results showed that expression of miR-451a was higher in the group where chemotherapy was effective than that patient where chemotherapy was ineffective. High serum levels of miR-451a were associated with longer overall survival and better prognosis of Hodgkin's lymphoma patients than patients who had lower serum miR-451a levels. Multivariate Cox-regression analysis identified miR-451a serum level was positively correlated with overall survival and prognosis in patients with Hodgkin's lymphoma.
Conclusion: The results of the present study demonstrate that serum levels of miR-451a is decreased in patients with Hodgkin's lymphoma. Data indicate that serum levels of miR-451a can be used as one of the potential biomarkers and prognosis for patients with Hodgkin's lymphoma.
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