Medicine最新文献

{"title":"Expression of interleukin-18 in primary Sjögren syndrome and its potential mechanisms with disease: A systematic review and meta-analysis.","authors":"Ying Deng, Yijue Wang, Yijuan Cheng, Min Lei, Yingyu Luo, Wenling Gu, Boyu Cai, Li Li, Nannan Zhang","doi":"10.1097/MD.0000000000041919","DOIUrl":"10.1097/MD.0000000000041919","url":null,"abstract":"<p><strong>Background: </strong>Interleukin-18 (IL-18), an IL-1 family cytokine with potent ability to induce interferon gamma production and enhance Th1 response, was elevated in a group of autoimmune diseases including primary Sjögren syndrome (pSS). IL-18 dysregulation can contribute to the pathogenesis of these disorders by exerting function in innate and adaptive immunity. This study is aimed at comparing the level of IL-18 in pSS patients and explored the association between IL-18 and pSS.</p><p><strong>Methods: </strong>Six databases, including PubMed, Web of Science, Embase, Ovid Medline, Scopus and China National Knowledge Infrastructure, were searched. The quality of the included studies was assessed using the Newcastle-Ottawa Scale criteria. We analyzed IL-18 concentrations in the serum and tear of pSS patients and healthy controls (HCs), and review the potential mechanism between IL-18 and pSS.</p><p><strong>Results: </strong>Eleven articles were included in this study, which reported IL-18 levels in serum and tear of pSS patients and HCs. IL-18 levels in pSS patients were significantly higher than those in HCs (standard mean difference = 1.28, 95% confidence interval 0.75-1.82, P < .001), with substantial heterogeneity (I2 = 90%, P < .001) among the studies. The level of IL-18 in serum was analyzed separately and was also higher than those in HCs (standard mean difference = 1.28, 95% confidence interval 0.68-1.88, P < .001), with significant heterogeneity (I2 = 91%, P < .001). Apart from that, the potential pathogenesis of pSS was concluded comprehensively.</p><p><strong>Conclusion: </strong>IL-18 abundance was evidently elevated in pSS patients and can thus likely be used as a reliable biomarker to monitor and track the progression of pSS, and further to become a good target for treatment of pSS patient.</p>","PeriodicalId":18549,"journal":{"name":"Medicine","volume":"104 12","pages":"e41919"},"PeriodicalIF":1.3,"publicationDate":"2025-03-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11936574/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143700883","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A case report of giant retroperitoneal liposarcoma.","authors":"Zicheng Bao, Nan Jia, Zhidong Zhang, Pingan Ding, Qun Zhao, Xuefeng Zhao, Yong Li","doi":"10.1097/MD.0000000000041923","DOIUrl":"10.1097/MD.0000000000041923","url":null,"abstract":"<p><strong>Rationale: </strong>Retroperitoneal liposarcoma (RPLS) is a rare malignancy with a high recurrence rate. Giant RPLS (≥30 cm) poses significant surgical challenges due to its invasive nature and compression of vital organs. Early diagnosis and multidisciplinary management are critical yet underreported in young patients. This case highlights the complexity of managing a 36-year-old male with a 60 cm × 50 cm × 40 cm tumor, emphasizing the importance of surgical precision and collaborative care.</p><p><strong>Patient concerns: </strong>The patient is a 36-year-old male who was admitted to the hospital due to abdominal distension presenting for over 7 months, accompanied by a rapid increase in abdominal girth for over the past 2 months. Based on his symptoms, physical examination findings, and imaging studies, the possibility of a giant retroperitoneal liposarcoma was considered.</p><p><strong>Diagnoses: </strong>Giant retroperitoneal liposarcoma.</p><p><strong>Interventions: </strong>The treatment involved the resection of the massive retroperitoneal tumor, along with partial resection of the descending colon, left ureterostomy drainage, and release of intestinal adhesions.</p><p><strong>Outcomes: </strong>The patient was discharged 14 days postoperatively with no immediate complications. Albumin levels improved to 35.2 g/L at 1-month follow-up. Telephone follow-ups at 3, 6, 12 months, and 5 years revealed no signs of recurrence on abdominal ultrasound.</p><p><strong>Lessons: </strong>The tumor had already invaded the surrounding organ tissues at the time of discovery in this case. Comprehensive preoperative evaluation, multidisciplinary collaboration in diagnosis and treatment, precise surgical techniques, and standardized intraoperative and postoperative management are essential to enhance surgical resection rates, minimize complications, and decrease the likelihood of postoperative recurrence.</p>","PeriodicalId":18549,"journal":{"name":"Medicine","volume":"104 12","pages":"e41923"},"PeriodicalIF":1.3,"publicationDate":"2025-03-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11936651/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143700888","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Altered intrinsic thalamic network based on electroencephalography source-level analysis in poststroke epilepsy.","authors":"Dong Ah Lee, Junghae Ko, Bong Soo Park, Kang Min Park","doi":"10.1097/MD.0000000000041886","DOIUrl":"10.1097/MD.0000000000041886","url":null,"abstract":"<p><p>This study aimed to investigate the alterations in the intrinsic thalamic network in patients with poststroke epilepsy (PSE) based on electroencephalography (EEG) source-level analysis. This retrospective observational study followed the STROBE guidelines. Thirty-nine patients with stroke and PSE and 34 patients with stroke without PSE were enrolled. These patients underwent EEG in a resting state. Source localization based on scalp electrical potentials was computed using the minimum norm imaging method and the standardized low-resolution brain electromagnetic tomography approach. To construct a functional connectivity matrix, the Talairach atlas was used to define the nodes belonging to the thalamus, and the coherence method was applied to measure brain synchronization as edges. The intrinsic thalamic network was analyzed using graph theory and compared between patients with and without PSE. EEG source-level analysis revealed notable differences in the intrinsic thalamic network between patients with and without PSE. From the undirected weighted connectivity matrix, the measure of modularity was lower in patients with PSE than in those without PSE (0.038 vs 0.106, P = .024). Additionally, modularity measures showed significant differences between the groups, as demonstrated by graph theoretical analysis using binary undirected graphs with a fixed density range of connections. This study is the first to demonstrate the alterations in the intrinsic thalamic network in patients with stroke with PSE compared to those without PSE based on EEG source-level analysis. These intrinsic thalamic network changes may be related to PSE development.</p>","PeriodicalId":18549,"journal":{"name":"Medicine","volume":"104 12","pages":"e41886"},"PeriodicalIF":1.3,"publicationDate":"2025-03-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11936616/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143700895","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Anatomic characteristics of the vertebrobasilar artery: A three-dimensional reconstruction study based on computed tomography angiography.","authors":"Qing Chao, YuanLiang Hu, Biao Zhao, YuXi Sun, Hansheng Shu, DaWei Wang, Zhe Cheng","doi":"10.1097/MD.0000000000041931","DOIUrl":"10.1097/MD.0000000000041931","url":null,"abstract":"<p><p>The vertebrobasilar artery (VBA) exhibits substantial inter-individual variation that must be considered in diagnosis and surgical planning. We conducted 3-dimensional reconstruction of the bilateral VBA based on head and neck computed tomography angiography (CTA) to assess bilateral, individual, age-dependent, and sex-dependent differences in anatomical parameters. A retrospective study was performed. Individual 3-dimensional models of the VBA and skull were constructed and morphology evaluated based on head and neck CTA data from 199 adults. According to morphological and anatomical variation, the VBA was divided into 3 types: balanced, L, and S. The diameters and lengths of basilar and bilateral vertebral artery (VA) intracranial segments as well as VBA blending length, and bilateral distances of the vertebral arteries moving up the atlas were measured and statistically compared. The L-type was the most common VBA morphology, and anatomic type distribution differed significantly by age (P < .05). VA diameter was 3.34 ± 0.68 mm on the left side and 3.09 ± 0.71 mm on the right side, while bending length was 5.62 ± 3.35 mm on the left and 4.94 ± 3.41 mm on the right side. Balanced basilar arteries measured 3.41 ± 0.61 mm in diameter, 2.83 ± 0.33 cm in length, and 2.55 ± 2.45 mm in bending length. The L-type basilar artery measured 3.48 ± 0.71 mm in diameter, 3.06 ± 0.44 cm in length, and 2.78 ± 0.37 mm in bending length. Finally, S-type basilar arteries measured 3.84 ± 0.86 mm in diameter, 3.38 ± 0.61 cm in length, and 3.67 ± 4.39 mm in bending length. The distance traveled by the VA across the atlas differed significantly between left and right sides as well as between males and females (P < .05). The vertebrobasilar arteries in the general healthy population were successfully fused and 3-dimensionally reconstructed based on the CTA, and an observational study was conducted on their morphological and anatomical characteristics. Three-dimensional reconstruction of the VBA using CTA is feasible for anatomical research and also has diagnostic value for the variations and anatomical parameters of the VBA.</p>","PeriodicalId":18549,"journal":{"name":"Medicine","volume":"104 12","pages":"e41931"},"PeriodicalIF":1.3,"publicationDate":"2025-03-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11936587/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143700901","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Mapping intellectual structure and research hotspots of cancer studies in primary health care: A machine-learning-based analysis.","authors":"Muhammet Damar, Hale Turhan Damar, Şeyda Özbiçakci, Gökben Yasli, Fatih Safa Erenay, Güzin Özdağoğlu, Andrew David Pinto","doi":"10.1097/MD.0000000000041749","DOIUrl":"10.1097/MD.0000000000041749","url":null,"abstract":"<p><p>In the contemporary fight against cancer, primary health care (PHC) services hold a significant and critical position within the healthcare system. This study, as one of the most detailed investigations into cancer research in primary care, comprehensively evaluates cancer studies from the perspective of PHC using bibliometric techniques and machine learning. The dataset for the analyses was sourced from the Web of Science (WoS) Core Collection database on March 20, 2024. The Bibliometrix package within the R programming environment, alongside the Biblioshiny application, and VOSViewer software were employed for the bibliometric analyses. In this study, Latent Dirichlet Allocation was utilized as a prominent topic modeling algorithm. The implementation of this technique utilized Python along with the SciKit-Learn and Gensim libraries, ensuring robust model development and evaluation. The 2040 articles were produced by a total of 6705 different authors, 2166 different affiliations, and 75 different countries. Cancer survivors are more vulnerable and need more sensitive health services. The most intensively studied 3 cancer types in the PHC, listed by prevalence, are colorectal cancer, breast cancer, and cervical cancer. Additionally, prominent research topics in PHC include cancer screening, diagnosis, early detection, prevention, education, genetic factors and family history, risk factors, symptoms/signs, preventive medicine, referral and consultation, chronic disease management and health services research for cancer patients, health care disparities, palliative care, and communication with patients in PHC. Family physicians, being the first point of contact with the public, play a crucial role in preventing cancer cases, caring for patients with active cancer diagnoses, supporting cancer survivors in their post-cancer lives, and identifying and referring cancer cases at the earliest stages. However, cancer has many types, each with its own distinct symptoms, as well as similar types to each other. At this point, periodic educational training for doctors on cancer by health authorities, regular publication of cancer-related guidance resources by the central healthcare system, development of integrated decision support tools used by physicians during patient care, and the creation of informative mobile applications for cancer prevention or post-cancer life for patients have been considered highly critical.</p>","PeriodicalId":18549,"journal":{"name":"Medicine","volume":"104 12","pages":"e41749"},"PeriodicalIF":1.3,"publicationDate":"2025-03-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11936571/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143700917","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Caries pattern and dental treatment features of children with autism spectrum disorder under general anesthesia.","authors":"Chun-Cheng Lai, Chia-Chan Wu","doi":"10.1097/MD.0000000000041867","DOIUrl":"10.1097/MD.0000000000041867","url":null,"abstract":"<p><p>Difficulty in the cooperation of children with autism spectrum disorder (ASD) leads to a poor diagnosis of caries patterns and poor clinical and radiographic findings. This study aimed to investigate the association between caries patterns and treatment characteristics in children with ASD and compare these variables with those in healthy children treated under general anesthesia. The medical records of children with ASD undergoing dental treatment under general anesthesia (n = 40) were analyzed in this study. The collected data included demographic profile, medical status (ASD severity and associated comorbidities), dental history (behavior, care approach, past dental treatment, and follow-up period), caries pattern (surface and depth), and clinical and radiographic findings (e.g., percussion/palpation pain, fistula, furcation involvement, and pathologic resorption). We compared the caries patterns and treatment of children with ASD to those of their healthy counterparts (n = 40). In children with ASD, age and severity were significantly associated with presentation behavior (P = .03 and P = .04) and the chosen care approach (P = .03). Clinical and radiographic examinations revealed that furcation involvement or pathological resorption was more frequent in children with ASD from families with lower average monthly income (P = .05) and in those with associated comorbidities (P = .02). Caries involving 1 or 2 surfaces were more prevalent in children with ASD, with a significant proportion extending to the dental pulp (P < .001). Dental caries characteristics and patterns among children with ASD differ from those of healthy children, which influences dental treatment decisions.</p>","PeriodicalId":18549,"journal":{"name":"Medicine","volume":"104 12","pages":"e41867"},"PeriodicalIF":1.3,"publicationDate":"2025-03-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11936631/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143700933","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Weaknesses and countermeasures of medical and health services for the aged in Sichuan province: A cross-sectional survey.","authors":"Qing Cao, Wendong Dong, Qian Huang, Xiang Huang, Zhiyi Wang, Daren Zhao","doi":"10.1097/MD.0000000000041910","DOIUrl":"10.1097/MD.0000000000041910","url":null,"abstract":"<p><p>Carry out a cross-sectional survey of medical and health services for the elderly in Sichuan province, understand the medical and health needs of the elderly in Sichuan province, analyze the existing problems and reasons, and then put forward feasible suggestions and opinions. Based on the top 10 single diseases in Sichuan province in 2021, hospitalized elderly patients suffering from the top 10 single diseases from January 2023 to April 2023 were selected as survey subjects, and the health status and medical and health service needs of the elderly population in Sichuan province were investigated using a questionnaire survey and statistical analysis. The sleep quality of the elderly in our province was generally not high, their basic health condition was poor, and the demand for basic medical services was high. There is a great need for medical care, especially for nutrition, medication, rehabilitation, and pain guidance. There is great demand for health education and management, especially for health examinations, health education, and health service systems. There is great demand for daily care, medical care services, mental health consultation, spiritual comfort, etc, and the referral demand is guaranteed to a certain extent, but it is still slightly insufficient in general. Allocating resources properly. The scientific cultivation of talent improves the healthcare system for the elderly and strengthens supervision. Active supply and innovative service methods. Focus on disabled and semi-disabled groups to reduce the burden.</p>","PeriodicalId":18549,"journal":{"name":"Medicine","volume":"104 12","pages":"e41910"},"PeriodicalIF":1.3,"publicationDate":"2025-03-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11936592/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143700971","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The 100 most cited articles in androgenetic alopecia: A bibliometric analysis.","authors":"Kinan Sawar, Louie Mekani, Alexander Kallabat, Dylan Kato, Geoffrey A Potts","doi":"10.1097/MD.0000000000041881","DOIUrl":"10.1097/MD.0000000000041881","url":null,"abstract":"<p><p>Androgenetic alopecia (AGA) is a condition with a rapidly evolving research landscape. The expanding volume of AGA research necessitates synthesis to identify trends and gaps. Bibliometric analysis can be used to quantify the characteristics of a body of literature, and this technique has not been previously applied to AGA. We aimed to evaluate the bibliometric characteristics of the top 100 most cited AGA articles over the past 50 years. This includes the analysis of contributing authorship, institutional affiliation, journal representation, publication years, citation counts, country productivity, and funding sources, among other characteristics. We used the Web of Science to identify and characterize the 100 most cited AGA publications between 1975 and 2024. A secondary analysis was performed to identify and characterize the top 20 most cited AGA articles from 2020 to 2024. The top 100 articles amassed 24,289 citations. Authors from the United States contributed the most articles (n = 56). The University of Pennsylvania contributed the most articles (n = 11). Dr Elise A Olsen and Dr George Cotsarelis were the most frequent contributors. The Journal of the American Academy of Dermatology published the most number of articles. From 1975 to 2024, most studies primarily discussed pathophysiology (45%) and treatment (35%). However, from 2020 to 2024, 75% of the top articles focused on the treatment options. This bibliometric analysis provides an overview of influential AGA research over the last 50 years, highlighting shifting trends toward treatment optimization and emerging therapies.</p>","PeriodicalId":18549,"journal":{"name":"Medicine","volume":"104 12","pages":"e41881"},"PeriodicalIF":1.3,"publicationDate":"2025-03-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11936583/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143700854","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Analysis of the therapeutic effect of acitretin capsules combined with cooling blood and detoxifying formula on psoriasis hemorrhagic fever and its impact on the gut microbiota of patients.","authors":"Mengyun Zhou, Zhaoyi Li, Jia Liu, Wei-Feng Zha, Yunyun Shan, Tianhong Xu","doi":"10.1097/MD.0000000000041502","DOIUrl":"10.1097/MD.0000000000041502","url":null,"abstract":"<p><p>This study evaluates the therapeutic effect of acitretin capsules combined with a cooling blood and detoxifying formula (CBDF) on psoriasis hemorrhagic fever and its impact on the gut microbiota (GM). Seventy patients diagnosed with psoriasis hemorrhagic fever between January 2022 and April 2023 were divided into 2 groups: an experimental group (EG) treated with acitretin capsules and the CBDF, and a control group treated with acitretin capsules alone. The study assessed immune inflammatory responses, symptom improvement, traditional Chinese medicine symptom scores, and changes in GM diversity and abundance before and after treatment. After 2 months, the EG showed significant reductions in interleukin-2 receptor levels (from 813.2 ± 201.5-402.3 ± 111.2 mg/L) and interleukin-6 (from 8.4 ± 3.1-3.8 ± 1.7 pg/mL). The quality of life index improved by 6.12 points in the EG, which was significantly better than the control group (P < .05). PASI scores decreased in both groups, with the EG showing greater improvement (PASI before treatment: 23.1 ± 4.3; after 1 month: 15.6 ± 3.8; after 2 months: 10.4 ± 3.3). The EG also showed a significant increase in GM diversity after treatment (P < .05). Acitretin capsules combined with the CBDF is effective in treating psoriasis hemorrhagic fever and positively affects the GM, offering a potential new treatment approach.</p>","PeriodicalId":18549,"journal":{"name":"Medicine","volume":"104 12","pages":"e41502"},"PeriodicalIF":1.3,"publicationDate":"2025-03-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11936573/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143700899","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Clinical diagnosis and treatment experience of 21 case report of isolated sphenoid sinus lesions.","authors":"Ziwei Yu, Yanli Yu, Xudong Chen, Yaowen Wang, Peng Cheng","doi":"10.1097/MD.0000000000041812","DOIUrl":"10.1097/MD.0000000000041812","url":null,"abstract":"<p><strong>Rationale: </strong>With the rapid development of medical science and technology, imaging has become an important part of the diagnosis of diseases, which can provide important information about the morphology and scope of the lesion and its relationship with the surrounding tissues. However, due to the fact that isolated pterygoid sinus lesions often have atypical clinical symptoms, and the location of the lesion is deep and the anatomical structure is complex, its diagnosis still faces one of the important challenges, and the misdiagnosis rate is high. The aim of this study was to explore the clinical symptoms, imaging manifestations, and postoperative pathological features of isolated pterygoid sinus lesions, and to summarize the key points of their diagnosis through systematic retrospective analysis, with a view to providing references for clinicians, reducing the misdiagnosis rate of this disease, and improving the level of diagnosis and treatment.</p><p><strong>Patient concerns: </strong>A retrospective analysis was conducted on the clinical data of 21 patients with isolated sphenoid sinus lesions diagnosed and treated in the ENT department of our hospital from January 2021 to January 2023. Among them, there were 12 cases of headache, 1 case of eye symptoms, 10 cases of nasal symptoms, and 1 case of facial symptoms upon admission.</p><p><strong>Diagnoses: </strong>Among the 21 cases, there were 10 cases of fungal sphenoid sinus inflammation, 3 cases of sphenoid sinus cyst, 4 cases of chronic sphenoid sinus inflammation, 1 case of sphenoid sinus polyp, 1 case of skull base schwannoma, 1 case of inverted papilloma of sphenoid sinus, and 1 case of cerebrospinal fluid rhinorrhea.</p><p><strong>Interventions: </strong>In this study, 21 patients underwent endonasal endoscopic pterygoid sinus opening, and all symptoms improved after surgery.</p><p><strong>Outcomes: </strong>The specific type and clinical manifestations of 21 cases of isolated pterygoid sinus lesions were clarified by imaging and postoperative pathological analysis.</p><p><strong>Lessons: </strong>Isolated pterygoid sinus lesions vary in type, and clinicians should combine clinical symptoms and imaging manifestations to improve diagnostic accuracy and reduce misdiagnosis. Systematic retrospective analysis helps to summarize diagnostic points and improve reference for clinical practice. Clinical symptoms and imaging examinations help to avoid misdiagnosis of this type of disease.</p>","PeriodicalId":18549,"journal":{"name":"Medicine","volume":"104 12","pages":"e41812"},"PeriodicalIF":1.3,"publicationDate":"2025-03-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11936579/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143700904","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}