基于拉曼光谱的血清内脂素特征峰筛选冠心病研究。

IF 1.3 4区医学 Q2 MEDICINE, GENERAL & INTERNAL

Medicine Pub Date : 2025-04-04 DOI:10.1097/MD.0000000000042081

Lujia Yang, Chaohui Lv, Zhongwei Yang, Feng Shi, Xiayan Liu

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引用次数: 0

摘要

本研究利用拉曼光谱分析健康人与冠心病患者血清内脂素及其亚组分的差异。探讨血清visfatin是否可作为CDH筛查的生物标志物。从新疆生产建设兵团第七师医院招募冠心病患者60例，健康人57例。采集血清样品，用拉曼光谱检测，分析血清visfatin特征峰。光谱峰分析显示，冠心病患者样品的850.95、1265.92、1336.99、1446.48、1603.83和1657.69 cm-1处的光谱峰较强，健康样品的1000.52、1154.51和1515.53 cm-1处的光谱峰较强。临床样本验证表明1265.92和1446.48 cm-1峰对冠心病患者和健康人有一定的区分作用。

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Serum visfatin characteristic peak screening coronary heart disease study based on Raman spectroscopy.

This study used Raman spectroscopy to explore differences between serum visfatin and its subcomponents in healthy people and coronary heart disease (CHD) patients. To explore whether serum visfatin can be used as screening biomarker for CDH. In total, 60 CHD patients and 57 healthy people were enrolled from Xinjiang Production and Construction Corps Seventh Division Hospital. Serum samples were collected and detected by Raman spectroscopy, and the characteristic peaks of serum visfatin were analyzed. The spectral peaks analysis showed, the peaks at 850.95, 1265.92, 1336.99, 1446.48, 1603.83, and 1657.69 cm-1 were stronger in the CHD patient sample, and the spectral peaks at 1000.52, 1154.51, and 1515.53 cm-1 were stronger in the healthy sample. Clinical sample verification revealed that the 1265.92 and 1446.48 cm-1 peaks had certain distinguishing effects on CHD patients and healthy people.

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来源期刊

Medicine 医学-医学：内科

CiteScore

2.80

自引率

0.00%

发文量

4342

审稿时长

>12 weeks

期刊介绍： Medicine is now a fully open access journal, providing authors with a distinctive new service offering continuous publication of original research across a broad spectrum of medical scientific disciplines and sub-specialties. As an open access title, Medicine will continue to provide authors with an established, trusted platform for the publication of their work. To ensure the ongoing quality of Medicine’s content, the peer-review process will only accept content that is scientifically, technically and ethically sound, and in compliance with standard reporting guidelines.