Medicine最新文献_第8页

Personalized aesthetic management of skeletal Class II malocclusion with a combined approach of orthodontic, orthognathic, and prosthodontic treatment: A case report.

IF 1.3 4区医学

Medicine Pub Date : 2025-02-07 DOI: 10.1097/MD.0000000000041326

Jinhan Nie, Min Hu, Huichuan Qi, Zhi Mao, Zhina Wu, Mengna Duan, Guomin Wu, Xue Yang, Yi Zhang

{"title":"Personalized aesthetic management of skeletal Class II malocclusion with a combined approach of orthodontic, orthognathic, and prosthodontic treatment: A case report.","authors":"Jinhan Nie, Min Hu, Huichuan Qi, Zhi Mao, Zhina Wu, Mengna Duan, Guomin Wu, Xue Yang, Yi Zhang","doi":"10.1097/MD.0000000000041326","DOIUrl":"10.1097/MD.0000000000041326","url":null,"abstract":"Rationale: The 6 elements of orofacial harmony play a crucial role in establishing individual aesthetics in orthodontics and orthognathic treatments. The use of digital tools streamlines multidisciplinary treatment processes and facilitates the attainment of precise outcomes.Patient concerns: The patient required orthodontic treatment because of a convex profile. UR1 was missing because of trauma and was replaced with a fixed bridge.Diagnoses: The patient presented with a skeletal Class II relationship and a deep overbite. Diagnosis based on the 6 elements of orofacial harmony identified an overdeveloped maxilla, a relatively normal mandible, and an underdeveloped chin with a vertical growth pattern.Interventions: To address these issues, a combined orthodontic and orthognathic treatment plan was implemented with a detailed surgical protocol developed according to these 6 elements. Customized brackets and 3D-printed occlusal plates were used in this study. After completing orthodontic treatment, an anterior prosthesis was designed using 3D digital technology to restore occlusal function and enhance anterior aesthetics.Outcomes: Post-treatment, the patient demonstrated reduced facial convexity, a flattened nasolabial sulcus, balanced occlusal forces, and restored occlusal function.Lessons: The outcomes of this case highlight the crucial role of the 6 elements of orofacial harmony in guiding the design and aesthetic planning of orthodontic and orthognathic treatment. In addition, the use of personalized treatment tools significantly enhances the treatment accuracy.","PeriodicalId":18549,"journal":{"name":"Medicine","volume":"104 6","pages":"e41326"},"PeriodicalIF":1.3,"publicationDate":"2025-02-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143389963","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The impact of second-victim syndrome on staff well-being and practice.

IF 1.3 4区医学

Medicine Pub Date : 2025-02-07 DOI: 10.1097/MD.0000000000041345

Moza Alishaq, Asmaa Kamal Hassan, Ahmed H Assar, Somaia Elfaki, Samia Mohmed Sobhi Mohamed, Sally Mohammed Farghaly Abdelaliem, Mohammed Hassan Elkordy

{"title":"The impact of second-victim syndrome on staff well-being and practice.","authors":"Moza Alishaq, Asmaa Kamal Hassan, Ahmed H Assar, Somaia Elfaki, Samia Mohmed Sobhi Mohamed, Sally Mohammed Farghaly Abdelaliem, Mohammed Hassan Elkordy","doi":"10.1097/MD.0000000000041345","DOIUrl":"10.1097/MD.0000000000041345","url":null,"abstract":"This study aimed to examine factors influencing psychological well-being and support among healthcare professionals involved in adverse event investigations, complaints, medical errors, and patient injuries from January 2020 to March 2022. The second-victim experience and support tool (SVEST) was used to assess second-victim experiences and support resources. Non-probability purposive sampling was employed, and data were collected through a Monkey Survey sent via email to around 150 clinicians (physicians, nurses, and pharmacists). A total of 100 responses were received. The inclusion criteria required participants to have been involved in adverse event investigations, complaints, medical errors, or patient-related injuries. The SVEST, with 29 items measured on a 5-point Likert scale, evaluated their perceptions of second-victim experiences and support resources. Institutional support was positively perceived by 55.0% of participants, with 52.0% feeling a range of coping resources was available. However, 31.0% felt their well-being was not adequately prioritized. Nonwork-related support was crucial, with 57.0% relying on friends and family. Professional self-efficacy was impacted, with 46.0% feeling inadequate and 39.0% experiencing self-doubt. Turnover intentions were notable, as 39.0% expressed a desire to leave patient care, and 34.0% considered quitting due to stress. This study highlights the need for targeted support systems to address second-victim experiences among healthcare professionals involved in adverse events. Enhancing institutional support, professional self-efficacy, and access to coping resources is crucial. Policymakers and healthcare leaders can help mitigate stress, decrease turnover intentions, and promote psychological resilience by fostering a supportive work environment and providing comprehensive resources, healthcare organizations can improve clinician well-being, reduce stress, and enhance patient care quality.","PeriodicalId":18549,"journal":{"name":"Medicine","volume":"104 6","pages":"e41345"},"PeriodicalIF":1.3,"publicationDate":"2025-02-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143391230","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

APOC3 as a potential prognostic factor for hepatitis B virus-related acute-on-chronic liver failure.

IF 1.3 4区医学

Medicine Pub Date : 2025-02-07 DOI: 10.1097/MD.0000000000041503

Bo Wang, Li Qiang, Geng Zhang, Wen Chen, Yunjian Sheng, Gang Wu, Cunliang Deng, Shan Zeng, Qian Zhang

{"title":"APOC3 as a potential prognostic factor for hepatitis B virus-related acute-on-chronic liver failure.","authors":"Bo Wang, Li Qiang, Geng Zhang, Wen Chen, Yunjian Sheng, Gang Wu, Cunliang Deng, Shan Zeng, Qian Zhang","doi":"10.1097/MD.0000000000041503","DOIUrl":"10.1097/MD.0000000000041503","url":null,"abstract":"Acute-on-chronic liver failure (ACLF) is the major cause of mortality in patients infected with the hepatitis B virus (HBV); however, early determination of the prognosis of patients with HBV-ACLF is insensitive or limited. This study aimed to analyze differentially expressed proteins in the plasma of patients with HBV-ACLF using data-independent acquisition mass spectrometry to provide a reference for short-term prognosis. Fifty HBV-ACLF patients and 15 healthy controls were enrolled in this study. Of these, 10 patients with HBV-ACLF and 5 healthy volunteers participated in data-independent acquisition-based proteomics and the potential core proteins were screened out via bioinformatics. Apolipoprotein C3 (APOC3) was selected and quantified by enzyme linked immunosorbent assays in all patients. And the area under the curve (AUC) was calculated to evaluate the value of APOC3 in the diagnosis and prognosis of patients with HBV-ACLF. A total of 247 differentially expressed proteins were identified in the serum of patients in the HBV-ACLF and normal control groups. A total of 148 proteins were upregulated and 99 proteins were downregulated in the HBV-ACLF group compared with those in the normal group. The expression level of APOC3 was 1.65 ± 0.44 mg/mL in patients with HBV-ACLF, which was obviously lower than the normal controls (2.04 ± 0.22 mg/mL) (P < .001) (AUC was 0.766, with a sensitivity of 62%, and specificity of 93.3%). The expression level of APOC3 was 1.38 ± 0.44 mg/mL in the non-survival group, which was obviously lower than the survival group (1.83 ± 0.35 mg/mL) (P < .0001) (AUC was 0.780, with a sensitivity of 50%, and specificity of 96.7%). APOC3 is associated with short-term prognosis of patients with HBV-ACLF and can be used as a potential prognostic biomarker in patients with HBV-ACLF.","PeriodicalId":18549,"journal":{"name":"Medicine","volume":"104 6","pages":"e41503"},"PeriodicalIF":1.3,"publicationDate":"2025-02-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143391276","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Factors influencing childbirth self-efficacy and vaginal delivery rates in Chongqing: An observational study.

IF 1.3 4区医学

Medicine Pub Date : 2025-02-07 DOI: 10.1097/MD.0000000000041382

Ding-Xiang Xing, Fei-Fei Li, Jun-Nan Li, Jia Chen, Xiao-Chang Yang

{"title":"Factors influencing childbirth self-efficacy and vaginal delivery rates in Chongqing: An observational study.","authors":"Ding-Xiang Xing, Fei-Fei Li, Jun-Nan Li, Jia Chen, Xiao-Chang Yang","doi":"10.1097/MD.0000000000041382","DOIUrl":"10.1097/MD.0000000000041382","url":null,"abstract":"This study aims to investigate the current status of childbirth self-efficacy among pregnant women in Chongqing Municipality, analyze the factors affecting childbirth self-efficacy, and provide relevant measures and evidence to improve childbirth self-efficacy and increase the rate of natural vaginal deliveries among pregnant women. This observational study employed a questionnaire survey method, involving 1142 pregnant women who underwent prenatal examinations at 6 hospitals in Chongqing in February 2023. Participants accessed the \"Wen-Juan-Xing\" app by scanning a QR code to fill out the questionnaire. Of the 1142 questionnaires distributed, 1086 were returned as valid, yielding a valid rate of 95.10%. The mean score on the Chinese Childbirth Self-Efficacy Inventory was 241.86 ± 60.25, while the mean score on the Perceived Social Support Scale among pregnant women was 67.05 ± 11.84. Planning for vaginal delivery and engaging in recommended prenatal exercises were identified as positive influencing factors for childbirth self-efficacy. Furthermore, a positive correlation was observed between childbirth self-efficacy and social support among pregnant women (P < .05). Engaging in recommending prenatal exercise and increasing social support among pregnant women can enhance their childbirth self-efficacy and promote a higher rate of natural vaginal childbirth.","PeriodicalId":18549,"journal":{"name":"Medicine","volume":"104 6","pages":"e41382"},"PeriodicalIF":1.3,"publicationDate":"2025-02-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143391293","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Application and effect evaluation of microsurgical resection combined with intensity-modulated radiation therapy in the treatment of intracranial solitary fibrous tumor/hemangiopericytoma. 显微外科切除联合调强放射治疗在颅内单发纤维瘤/血管瘤治疗中的应用及效果评估

IF 1.3 4区医学

Medicine Pub Date : 2025-02-07 DOI: 10.1097/MD.0000000000041336

Jingcheng Jiang, Xiaoqin Qu, Han Wang, Chao Zhang, Qingshan Deng, Xiaoping Xu, Jun Qiu, Lihua Qu, Yong Yi

{"title":"Application and effect evaluation of microsurgical resection combined with intensity-modulated radiation therapy in the treatment of intracranial solitary fibrous tumor/hemangiopericytoma.","authors":"Jingcheng Jiang, Xiaoqin Qu, Han Wang, Chao Zhang, Qingshan Deng, Xiaoping Xu, Jun Qiu, Lihua Qu, Yong Yi","doi":"10.1097/MD.0000000000041336","DOIUrl":"10.1097/MD.0000000000041336","url":null,"abstract":"Intracranial solitary fibrous tumor (SFT) and hemangiopericytoma (HPC) are rare mesenchymal tumors with significant vascularization, often misdiagnosed as meningiomas. Surgical resection is the primary treatment, with postoperative radiotherapy increasingly recognized for its role in improving recurrence-free survival. However, standard radiotherapy regimens remain undefined. We retrospectively analyzed clinical data from 12 patients diagnosed with SFT/HPC who underwent surgical resection and postoperative intensity-modulated radiotherapy. Clinical information, imaging findings, treatment methods, and outcomes were reviewed. Surgical resection achieved complete or subtotal tumor removal in all cases. Postoperative radiotherapy was administered to 8 patients. During follow-up, 3 patients experienced tumor recurrence, necessitating reoperation, while 1 patient died due to complications. Those who received radiotherapy showed a trend towards reduced recurrence. Surgical resection remains the cornerstone of SFT/HPC treatment, with adjuvant radiotherapy potentially improving outcomes. However, individualized treatment strategies and long-term follow-up are crucial due to the tumor's propensity for recurrence. Further research is needed to optimize treatment approaches and enhance patient survival and quality of life.","PeriodicalId":18549,"journal":{"name":"Medicine","volume":"104 6","pages":"e41336"},"PeriodicalIF":1.3,"publicationDate":"2025-02-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143391278","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Portal vein thrombosis complicating neonatal umbilical vein catheterization in a 3-month-old infant with coincidental extrahepatic biliary atresia: A case report.

IF 1.3 4区医学

Medicine Pub Date : 2025-01-31 DOI: 10.1097/MD.0000000000041238

Mortada H F El-Shabrawi, Ayman Hussein Abdel Sattar, Fetouh Hassanin, Maha Fathy Sheba, Ahmed Elhennawy, Naglaa M Kamal, Mohammed A M Oshi, Ali Algarni, Seham Anwar Emam Marzouk

{"title":"Portal vein thrombosis complicating neonatal umbilical vein catheterization in a 3-month-old infant with coincidental extrahepatic biliary atresia: A case report.","authors":"Mortada H F El-Shabrawi, Ayman Hussein Abdel Sattar, Fetouh Hassanin, Maha Fathy Sheba, Ahmed Elhennawy, Naglaa M Kamal, Mohammed A M Oshi, Ali Algarni, Seham Anwar Emam Marzouk","doi":"10.1097/MD.0000000000041238","DOIUrl":"10.1097/MD.0000000000041238","url":null,"abstract":"Rationale: Umbilical vein catheterization (UVC) is a common procedure in neonatal intensive care units (NICU) but carries risks of severe complications such as portal vein thrombosis (PVT). Extrahepatic biliary atresia (EHBA), a leading cause of neonatal cholestasis, often progresses to end-stage liver disease. This case report discusses the rare coexistence of PVT and EHBA in a 3-month-old infant, highlighting the critical need for timely diagnosis and intervention.Patient concerns: A 3-month-old female presented with jaundice, dark-colored urine, and clay-colored stools. She had a history of NICU admission for neonatal sepsis during which a UVC was inserted.Diagnoses: Physical examination revealed jaundice and hepatosplenomegaly. Abdominal ultrasonography identified hepatosplenomegaly, mild ascites, and portal cavernoma. A liver biopsy confirmed a diagnosis of EHBA.Interventions: The patient underwent Kasai portoenterostomy. Postoperatively, she developed complications including ascites, systemic hypertension, and hyperammonemia. Initial improvements were observed with decreased bilirubin levels.Outcomes: Despite initial stabilization, the patient's condition deteriorated, and she succumbed on day 15 postoperation.Lessons: This case underscores the significant risks of PVT associated with UVC and the importance of monitoring NICU graduates for early detection of complications. The early onset of portal hypertension and esophageal varices in this case challenges existing beliefs about EHBA's clinical progression. Greater awareness and routine follow-up imaging are essential to improve outcomes in similar scenarios.","PeriodicalId":18549,"journal":{"name":"Medicine","volume":"104 5","pages":"e41238"},"PeriodicalIF":1.3,"publicationDate":"2025-01-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11789905/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143070978","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Septic cardiomyopathy or myocardial infarction?: A case report of septic shock with ST-segment elevation on ECG.

IF 1.3 4区医学

Medicine Pub Date : 2025-01-31 DOI: 10.1097/MD.0000000000041454

Haolei Gao, Xiaodong Wang, Qingyue Yang

{"title":"Septic cardiomyopathy or myocardial infarction?: A case report of septic shock with ST-segment elevation on ECG.","authors":"Haolei Gao, Xiaodong Wang, Qingyue Yang","doi":"10.1097/MD.0000000000041454","DOIUrl":"10.1097/MD.0000000000041454","url":null,"abstract":"Rationale: Sepsis is one of the most prevalent and deadly diseases today. Sepsis involving the heart can progress to septic cardiomyopathy; however, there is a lack of uniform diagnostic criteria. A review of the literature reveals a paucity of literature on sepsis combined with acute myocardial infarction (AMI) and no reports on emergency surgical treatment.Patients concerns: A 52-year-old patient with trauma-induced sepsis leading to acute heart failure with elevated ST-segment on electrocardiogram and postoperative coronary angiography suggestive of AMI.Diagnoses: Small bowel rupture, infectious shock, AMI, hypertensive disease, old cerebral infarction.Interventions: The patient was admitted to the hospital and immediately underwent emergency surgery to remove the infected focus, with treatment with meropenem for anti-infection, ambroxol for sputum, parenteral nutritional support, sedation and analgesia, esmolol to control the ventricular rate, uradil to control blood pressure, and transfusion of red blood cells and plasma for correction of anemia and coagulation functions. Coronary angiography was performed 6 months later.Outcomes: The patient was discharged after showing signs of improvement and was subsequently monitored in an outpatient clinic setting. At the time of writing, the patient is still alive and well.Lessons: In cases of acute heart failure resulting from trauma-induced sepsis, it is crucial to consider myocardial ischemia as a potential factor. Early surgical removal of infected foci may prove beneficial in improving the patient's prognosis. However, differentiating between septic cardiomyopathy and sepsis-combined myocardial infarction can be challenging, and the appropriateness of the diagnostic criteria for sepsis at this stage is debatable.","PeriodicalId":18549,"journal":{"name":"Medicine","volume":"104 5","pages":"e41454"},"PeriodicalIF":1.3,"publicationDate":"2025-01-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11789888/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143070997","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Ultrasound-guided versus blind arthrocentesis in knee osteoarthritis: A systematic review and meta-analysis.

IF 1.3 4区医学

Medicine Pub Date : 2025-01-31 DOI: 10.1097/MD.0000000000041389

Xiaoyan Deng, Yamei Li, Daishun Li

{"title":"Ultrasound-guided versus blind arthrocentesis in knee osteoarthritis: A systematic review and meta-analysis.","authors":"Xiaoyan Deng, Yamei Li, Daishun Li","doi":"10.1097/MD.0000000000041389","DOIUrl":"10.1097/MD.0000000000041389","url":null,"abstract":"Background: To summarize the current evidence about effectiveness and accuracy of using ultrasound-guided compared to blind arthrocentesis in the treatment of knee osteoarthritis.Methods: Web of Science, the Cochrane Central Register of Controlled Trials, EMBASE, Scopus, PubMed, ClinicalTrials.gov, Wangfang Database, and SinoMed were conducted from their inception to February 2024. Eligible studies included Randomized controlled trials (RCTs) and non-RCTs that compared the ultrasound-guided and blind arthrocentesis in knee osteoarthritis, with outcomes assessed base on pain, function, accuracy, and additional factors such as satisfaction, cost-effectiveness, fluid yield, and synovial membrane thickness.Results: Twenty-one studies that met the inclusion criteria (1924 patients) were identified. The results indicated that ultrasound-guided arthrocentesis was superior to blind arthrocentesis (10 trials; MD = -0.37; 95% CI = -0.55 to -0.19; P = .000). However, no significant difference was found in function improvement (7 trials; SMD = -0.60; 95% CI = -1.31 to 0.12; P = .101). Ultrasound-guided arthrocentesis also demonstrated better accuracy compared to blind arthrocentesis (RR = 1.26, 95% CI: 1.09-1.46, P = .001). For satisfaction, the result reported ultrasound was better than the blind group (MD = 1.11; 95% CI = 0.67-1.54; P = .000) at immediate post-procedure, and at the 4 to 6 weeks (MD = 0.98; 95% CI = 0.56-1.41; P = .000).Conclusion: In the comprehensive systematic review and meta-analysis of knee osteoarthritis, ultrasound-guided arthrocentesis is superior to anatomic landmark-guided arthrocentesis in terms of pain reduction and accuracy.","PeriodicalId":18549,"journal":{"name":"Medicine","volume":"104 5","pages":"e41389"},"PeriodicalIF":1.3,"publicationDate":"2025-01-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11789915/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143071061","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Network pharmacology predicts targets and pathways of herbal components for the treatment of pneumonia: A review.

IF 1.3 4区医学

Medicine Pub Date : 2025-01-31 DOI: 10.1097/MD.0000000000041372

Dongxin Yang, Cuilian Chen, Qingshang Zhang, Jun Gong

{"title":"Network pharmacology predicts targets and pathways of herbal components for the treatment of pneumonia: A review.","authors":"Dongxin Yang, Cuilian Chen, Qingshang Zhang, Jun Gong","doi":"10.1097/MD.0000000000041372","DOIUrl":"10.1097/MD.0000000000041372","url":null,"abstract":"Pneumonia is a respiratory disease with high pathogenicity and mortality. Traditional Chinese medicine (TCM) is a natural therapy that has proven effectiveness and safety. Although TCM has been found to be effective in treating pneumonia, further research is needed to determine the specific mechanism of action. This paper presents a literature search conducted in PubMed, Web of Science, and China National Knowledge Infrastructure (CNKI) databases using the keywords \"pneumonia\" and \"network pharmacology.\" After screening, we retained the literature related to TCM. The study found that, according to network pharmacology prediction, 4 types of TCMs-natural active compounds, single herb medicine, Chinese patent medicines, and multi-component herbal formulations-were effective in treating pneumonia. TCM components demonstrated a multi-target and multi-pathway approach to treat the disease. The diversity of targets and signaling pathways not only facilitates the investigation of TCM's mechanism of action of TCM in pneumonia treatment but also offers novel insights and perspectives for innovative drug research and development.","PeriodicalId":18549,"journal":{"name":"Medicine","volume":"104 5","pages":"e41372"},"PeriodicalIF":1.3,"publicationDate":"2025-01-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11789858/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143070919","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Rare association of granulomatosis with polyangiitis with an underdiagnosed spondyloarthritis effectively treated with rituximab: A case-report. 肉芽肿伴多血管炎与诊断不足的脊柱关节炎的罕见关联，利妥昔单抗治疗有效：病例报告。

IF 1.3 4区医学

Medicine Pub Date : 2025-01-31 DOI: 10.1097/MD.0000000000041366

Thomas Escoda, Aurélie Dehaene, Laetitia Velardocchio, Arnaud Deveze, Benjamin Terrier, Laurent Chiche

{"title":"Rare association of granulomatosis with polyangiitis with an underdiagnosed spondyloarthritis effectively treated with rituximab: A case-report.","authors":"Thomas Escoda, Aurélie Dehaene, Laetitia Velardocchio, Arnaud Deveze, Benjamin Terrier, Laurent Chiche","doi":"10.1097/MD.0000000000041366","DOIUrl":"10.1097/MD.0000000000041366","url":null,"abstract":"Rationale: Associations of autoimmune diseases are rare but interesting and challenging situations from a diagnostic, pathophysiological, and therapeutic point of view. This article studies a rare association of autoimmune diseases by discussing the pathophysiological hypotheses and an original therapeutic management. The coexistence of antineutrophil cytoplasmic antibody-associated vasculitis and spondyloarthritis has rarely been described.Patient concerns: We present a patient with inflammatory back pain, stiffness, and enthesopathies followed by pulmonary and ear, nose and throat granulomatous involvement.Diagnoses: A combination of spondyloarthritis and granulomatosis with polyangiitis, with spinal, enthesopathic, pulmonary, and ear, nose and throat involvement.Interventions and outcomes: Effective treatment with rituximab both on spondyloarthritis and vasculitis.Lessons: We discuss the pathogenic, diagnostic, and therapeutic implications of this rare but intriguing association between these 2 inflammatory conditions.","PeriodicalId":18549,"journal":{"name":"Medicine","volume":"104 5","pages":"e41366"},"PeriodicalIF":1.3,"publicationDate":"2025-01-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11789892/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143070986","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0