Relationship between temporal white matter projections and cognition in patients with putaminal hemorrhage: An observational study.

Abstract

Cognitive impairment in patients with putaminal hemorrhage (PH) is not well understood, particularly the role of temporal white matter projections. The temporal white matter projections (cingulum, superior longitudinal fasciculus, inferior longitudinal fasciculus, and uncinate fasciculus [UF]) is involved in the cognitive function. Therefore, a brain injury involving the temporal white matter projections results in cognitive impairment. However, few studies have reported the pathophysiological mechanisms associated with cognitive impairment in patients with PH. Hence, in this study, using diffusion tensor tractography (DTT), the relationship between the temporal white matter projections and cognition was analyzed in patients with PH. Twenty-five patients with PH were recruited for this study. A Mini-Mental State Examination (MMSE) was conducted for the cognitive function. DTT was used to evaluate the structural integrity of temporal white matter projections (cingulum, superior longitudinal fasciculus, inferior longitudinal fasciculus, and UF). Pearson correlation and multiple regression analyses were also performed to determine the relationship between the DTT parameters of the temporal white matter projections and the MMSE. An analysis of the correlations showed that the integrity and fiber number of the UF were linked to cognitive performance on the MMSE. In addition, the fiber number of the UF on the MMSE at 6 months from the onset had an explanatory power of 33% and showed the 0.064 for unstandardized coefficients. Using DTT, this study demonstrated that the uncinate fasciculus's fiber number was a strong predictor of cognitive outcomes 6 months post-PH, accounting for 33% of the variance in MMSE scores. Therefore, our findings suggest that early assessment of the UF using DTT may inform prognosis and rehabilitation strategies for PH patients.